Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
A1-glycolipid + H2O
?
-
-
-
-
?
Ab-glycolipid + H2O
?
-
-
-
-
?
erythroglycan + H2O
?
-
-
-
-
?
Fucalpha1-2Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glc + H2O
?
-
-
-
-
?
Fucalpha1-2Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glc-Cer + H2O
Fucalpha1-2Galbeta1-3GlcNAcbeta1-3Gal + Glc-Cer
Gal(beta1-4)GlcNAc(beta1-3)Gal(beta1-4)sorbitol + H2O
Gal(beta1-4)GlcNAc(beta1-3)Gal + sorbitol
-
-
-
?
Galalpha1-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc-Cer + H2O
?
Galbeta1-3GlcNAc(6-2alphaNeuAc)beta1-3Galbeta1-4Glc + H2O
?
-
-
-
-
?
Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glc + H2O
?
Galbeta1-3[Fucalpha1-4]GlcNAcbeta1-3Galbeta1-4Glc + H2O
?
Galbeta1-3[Fucalpha1-4]GlcNAcbeta1-3Galbeta1-4Glc-Cer + H2O
Galbeta1-3[Fucalpha1-4]GlcNAcbeta1-3Gal + Glc-Cer
Galbeta1-4GlcNAcbeta1-3Galbeta1-3Galbeta1-4Glc-Cer + H2O
Galbeta1-4GlcNAcbeta1-3Galbeta1-3Gal + Glc-Cer
Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc + H2O
?
glycosphingolipids + H2O
?
-
lacto-N-glycosylceramide series having the common structure R-GlcAcbeta1-3Galbeta1-4Glc(or GlcNAc) are hydrolyzed at Galbeta1-4Glc (or GlcNAC) linkages. beta-Galactosyl linkages in globo series or ganglio series of glycolipids are not hydrolyzed
-
-
?
H1-glycolipid + H2O
?
-
-
-
-
?
keratan sulfate + H2O
keratan oligosaccharides
lacto-N-fucopentaose I + H2O
?
-
-
-
-
?
lacto-N-fucopentaose II + H2O
?
-
-
-
-
?
lacto-N-fucopentaose III + H2O
?
-
-
-
-
?
lacto-N-neotetraosylceramide + H2O
?
-
-
-
-
?
lacto-N-tetraitol + H2O
sorbitol + Galbeta(1-3)GlcNAcbeta(1-3)Gal
-
-
-
?
lacto-N-tetraose + H2O
?
-
-
-
-
?
lacto-N-tetraose + H2O
glucose + Galbeta(1-3)GlcNAcbeta(1-3)Gal
mucin + H2O
GlcNAcbeta(1-3)Gal + GlcNAc-6Sbeta(1-3)Gal + resistant polymer
-
desialyzed pig colonic mucin
-
?
neolacto-type glycosphingolipid + H2O
glucosylceramide + ?
NeuAcalpha2-3Galbeta1-3GlcNAc(6-2alphaNeuAc)beta1-3Galbeta1-4Glc + H2O
?
-
-
-
-
?
NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc-Cer + H2O
NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-3Gal + Glc-Cer
NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-4Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glc-Cer + H2O
NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-4Galbeta1-3GlcNAcbeta1-3Gal + Glc-Cer
NeuAcalpha2-6Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc + H2O
?
-
-
-
-
?
paragloboside + H2O
?
-
-
-
-
?
polyglycosylceramides + H2O
?
-
in absence of sodium taurodeoxycholate conversion into at least three shorter-chain glycosphingolipids, in presence of sodium taurodeoxycholate conversion into glucosylceramide
in absence of sodium taurodeoxycholate conversion into at least three shorter-chain glycosphingolipids, in presence of sodium taurodeoxycholate conversion into glucosylceramide
?
sialosylparagloboside + H2O
?
-
-
-
-
?
sulfated glycosaminoglycan + H2O
N-acetyl-D-glucosamine-6-sulfate + ?
-
pH 6.8
-
-
?
additional information
?
-
Fucalpha1-2Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glc-Cer + H2O
Fucalpha1-2Galbeta1-3GlcNAcbeta1-3Gal + Glc-Cer
-
-
-
?
Fucalpha1-2Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glc-Cer + H2O
Fucalpha1-2Galbeta1-3GlcNAcbeta1-3Gal + Glc-Cer
-
-
-
?
Galalpha1-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc-Cer + H2O
?
-
-
-
-
?
Galalpha1-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc-Cer + H2O
?
-
no activity
-
-
?
Galalpha1-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc-Cer + H2O
?
-
-
-
-
?
Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glc + H2O
?
-
-
-
-
?
Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glc + H2O
?
-
-
-
-
?
Galbeta1-3[Fucalpha1-4]GlcNAcbeta1-3Galbeta1-4Glc + H2O
?
-
-
-
-
?
Galbeta1-3[Fucalpha1-4]GlcNAcbeta1-3Galbeta1-4Glc + H2O
?
-
-
-
-
?
Galbeta1-3[Fucalpha1-4]GlcNAcbeta1-3Galbeta1-4Glc-Cer + H2O
Galbeta1-3[Fucalpha1-4]GlcNAcbeta1-3Gal + Glc-Cer
-
-
-
?
Galbeta1-3[Fucalpha1-4]GlcNAcbeta1-3Galbeta1-4Glc-Cer + H2O
Galbeta1-3[Fucalpha1-4]GlcNAcbeta1-3Gal + Glc-Cer
-
-
-
?
Galbeta1-4GlcNAcbeta1-3Galbeta1-3Galbeta1-4Glc-Cer + H2O
Galbeta1-4GlcNAcbeta1-3Galbeta1-3Gal + Glc-Cer
-
-
-
?
Galbeta1-4GlcNAcbeta1-3Galbeta1-3Galbeta1-4Glc-Cer + H2O
Galbeta1-4GlcNAcbeta1-3Galbeta1-3Gal + Glc-Cer
-
-
-
?
Galbeta1-4GlcNAcbeta1-3Galbeta1-3Galbeta1-4Glc-Cer + H2O
Galbeta1-4GlcNAcbeta1-3Galbeta1-3Gal + Glc-Cer
-
-
-
-
?
Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc + H2O
?
-
-
-
-
?
Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc + H2O
?
-
-
-
-
?
keratan sulfate + H2O
keratan oligosaccharides
-
from bovine cornea
-
-
?
keratan sulfate + H2O
keratan oligosaccharides
-
from bovine cornea
more than 75% of the oligosaccharides are sulfated unbranched poly(N-acetyllactosamine) sequences, (-3/4GlcNAcbeta1-3Galbeta1-)n. SO3-beta1-3Gal accounts for almost 35% of the oligosaccharide material while 40% consists of four oligosaccharides, unbranched tetrasaccharides, hexasaccharides, octasaccharides and decasaccharides of poly(N-acetyllactosamine)type, having 3, 5, 7 and 9 sulfate residues respectively. A sulfate residue is attached to the C6 position of each N-acetylglucosamine and each internal galactose residue of the four oligosaccharides
?
keratan sulfate + H2O
keratan oligosaccharides
-
from bovine cornea
GlcNAcbeta1-3Gal + sulfated disaccharides, trisaccharides, tetrasaccharides, hexasaccharides, octasaccharides and decasaccharides based on the sequence (-3/4GlcNAcbeta1-3Galbeta1-), having 1, 3, 5, 7 and 9 sulfate groups
?
keratan sulfate + H2O
keratan oligosaccharides
-
-
-
-
?
keratan sulfate + H2O
keratan oligosaccharides
-
-
6-O-sulfo-GlcNAcbeta1-3Gal is the major product
?
keratan sulfate + H2O
keratan oligosaccharides
-
-
2-acetamido-2-deoxy-6-O-sulfo-beta-D-Gal-(1-3)-D-Gal + 2-acetamido-2-deoxy-6-O-sulfo-beta-D-Glc-(1-3)-6-O-sulfoD-Gal-(1-4)-2-acetamido-2-deoxy-6-O-sulfo-beta-D-Glc-(1-3)-D-Gal
?
keratan sulfate + H2O
keratan oligosaccharides
-
from teleost skin
6-O-sulfo-GlcNAcbeta1-3Gal is one of the major products, GlcNAcbeta1-3Gal
?
keratan sulfate + H2O
keratan oligosaccharides
-
-
-
-
?
keratan sulfate + H2O
keratan oligosaccharides
-
from teleost skin
no production of GlcNAcbeta1-3Gal, 6-O-sulfo-GlcNAcbeta1-3Gal is one of the major products
?
keratan sulfate + H2O
keratan oligosaccharides
-
keratan sulfate chains from bovine articular cartilage. Presence of fucose on N-acetylglucosamine residues in keratan sulfates protects both of the adjacent unsulfated galactose residues from keratanase cleavage
GlcNAc(6S)beta1-3Galbeta1-4(Fucalpha1-3)GlcNAc(6S)beta1-3Galbeta1-4GlcNAc(6S)beta1-3Gal-ol + GlcNAc(6S)beta1-3Galbeta1-4(Fucalpha-3)GlcNAc(6S)beta1-3Galbeta1-4GlcNAc(6S)beta1-6(Galbeta1-33)GalNAc-ol
?
keratan sulfate + H2O
keratan oligosaccharides
-
-
-
-
?
keratan sulfate + H2O
keratan oligosaccharides
-
from nasal carilage
-
-
?
keratan sulfate + H2O
keratan oligosaccharides
-
from teleost skin
6-O-sulfo-GlcNAcbeta1-3Gal is one of the major products, GlcNAcbeta1-3Gal
?
lacto-N-tetraose + H2O
glucose + Galbeta(1-3)GlcNAcbeta(1-3)Gal
-
-
-
?
lacto-N-tetraose + H2O
glucose + Galbeta(1-3)GlcNAcbeta(1-3)Gal
-
-
-
-
?
neolacto-type glycosphingolipid + H2O
glucosylceramide + ?
-
hydrolysis of the internal beta1,4-galactosyl linkage of various neolacto-type glycosphingolipids to produce glucosylceramides
-
?
neolacto-type glycosphingolipid + H2O
glucosylceramide + ?
-
hydrolysis of the internal beta1,4-galactosyl linkage of various neolacto-type glycosphingolipids to produce glucosylceramides
-
?
NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc-Cer + H2O
NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-3Gal + Glc-Cer
-
-
-
?
NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc-Cer + H2O
NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-3Gal + Glc-Cer
-
-
-
?
NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc-Cer + H2O
NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-3Gal + Glc-Cer
-
-
-
-
?
NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc-Cer + H2O
NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-3Gal + Glc-Cer
-
-
-
?
NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-4Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glc-Cer + H2O
NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-4Galbeta1-3GlcNAcbeta1-3Gal + Glc-Cer
-
-
-
?
NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-4Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glc-Cer + H2O
NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-4Galbeta1-3GlcNAcbeta1-3Gal + Glc-Cer
-
no activity
-
-
?
NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-4Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glc-Cer + H2O
NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-4Galbeta1-3GlcNAcbeta1-3Gal + Glc-Cer
-
-
-
?
additional information
?
-
-
hydrolyzes the type 2 sequence Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc at about twice the rate of the type 1 isomer, Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glc
-
-
?
additional information
?
-
-
no activity with Galbeta1-4GlcNAcbeta1-6Galbeta1-4GlcNAcbeta1-6(Galbeta1-3)GalNAc-ol
-
-
?
additional information
?
-
-
AB active blood group substance can be hydrolyzed only after Smith degradation
-
-
?
additional information
?
-
-
induced with high efficiency in culture medium containing Smith-degraded gastric mucin
-
-
?
additional information
?
-
-
sialosyl substitution at the terminal galactosyl residue of lacto-N-neotetraosyl structure of paragloboside greatly enhances the hydrolyzability of the internal Galbeta1-4Glc linkage, thus producing a high yield of sialotetrasaccharide (AcNeualpha2-3Galbeta1-4GlcNAcbeta-3Gal). The Galbeta1-4GlcNAc linkage located in the middle of the repeating Galbeta1-4GlcNAc(or Glc) unit seen in H2-glycolipid or Ab-glycolipid, (R-Galbeta1-4GlcNAcbeta1-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc-Cer) is preferentially hydrolyzed relative to the Galbeta1-4Glc linkage directly attached to ceramide. The branched structure as is found in H3-glycolipid greatly reduces the hydrolyzability
-
-
?
additional information
?
-
-
hydrolyzes glycoconjugates containing N-acetyllactosamine repeating units
-
-
?
additional information
?
-
-
the enzyme is produced without induction by keratan sulfate
-
-
?
additional information
?
-
-
the enzyme is produced without induction by keratan sulfate
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Maaheimo, H.; Penttil, L.; Renkonen, O.
Enzyme-aided construction of medium-sized alditols of complete O-linked saccharides. The constructed hexasaccharide alditol Galbeta1-4GlcNAcbeta1-6Galbeta1-4GlcNAcbeta1-6(Galbeta1-3)GalNAc-ol resists the action of endo-beta-galactosidase from Bacteroides fragilis
FEBS Lett.
349
55-59
1994
Bacteroides fragilis
brenda
Leng, L.; Zhu, A.; Zhang, Z.; Hurst, R.; Goldstein, J.
Cloning, functional expression and purification of endo-beta-galactosidase from Flavobacterium keratolyticus
Gene
222
187-194
1998
Sphingobacterium multivorum
brenda
Fukuda, M.; Matsumara, G.
endo-beta-Galactosidase of Escherichia freundii. Hydrolysis of pig colonic mucin and milk oligosaccharides by endoglycosidic action
Biochem. Biophys. Res. Commun.
64
465-471
1975
Citrobacter freundii
brenda
Fukuda, M.; Watanabe, K.; Hakomori, S.I.
Release of oligosaccharides from various glycosphingolipids by endo-beta-galactosidase
J. Biol. Chem.
253
6814-6819
1978
Escherichia coli
brenda
Fukuda, M.
Purification and characterization of endo-beta-galactosidase from Escherichia freundii induced by hog gastric mucin
J. Biol. Chem.
256
3900-3905
1981
Citrobacter freundii
brenda
Nakagawa, H.; Yamada, T.; Chien, J.L.; Gardas, A.; Kitamikado, M.; Li, S.C.; Li, Y.T.
Isolation and characterization of an endo-beta-galactosidase from a new strain of Escherichia freundii
J. Biol. Chem.
255
5955-5959
1980
Citrobacter freundii
brenda
Kitamikado, M.; Ito, M.; Li, Y.T.
Isolation and characterization of a keratan sulfate-degrading endo-beta-galactosidase from Flavobacterium keratolyticus
J. Biol. Chem.
256
3906-3909
1981
Sphingobacterium multivorum
brenda
Kitamikado, M.; Ito, M.; Li, Y.T.
endo-beta-Galactosidase from Flavobacterium keratolyticus
Methods Enzymol.
83
619-625
1982
Sphingobacterium multivorum
brenda
Li, Y.T.; Nakagawa, H.; Kitamikado, M.; Li, S.C.
endo-beta-Galactosidase from Escherichia freundii
Methods Enzymol.
83
610-619
1982
Citrobacter freundii
brenda
Scudder, P.; Uemura, K.i.; Dolby, J.; Fukuda, M.N.; Feizi, T.
Isolation and characterization of an endo-beta-galactosidase from Bacteroides fragilis
Biochem. J.
213
484-494
1983
Bacteroides fragilis
-
brenda
Hounsell, E.F.; Feeney, J.; Scudder, P.; Tang, P.W.; Feizi, T.
1H-NMR studies at 500 MHz of a neutral disaccharide and sulphated di-, tetra-, hexa- and larger oligosaccharides obtained by endo-beta-galactosidase treatment of keratan sulphate
Eur. J. Biochem.
157
375-384
1986
Bacteroides fragilis
brenda
Scudder, P.; Tang, P.W.; Hounsell, E.F.; Lawson, A.M.; Mehemet, H.; Feizi, T.
Isolation and characterization of sulphated oligosaccharides released from bovine corneal keratan sulphate by the action of endo-beta-galactosidase
Eur. J. Biochem.
157
365-373
1986
Bacteroides fragilis
brenda
Ito, M.; Hirabayashi, Y.; Yamagata, T.
Substrate specificity of endo-beta-galactosidases from Flavobacterium keratolyticus and Escherichia freundii is different from that of Pseudomonas sp.
J. Biochem.
100
773-780
1986
Citrobacter freundii, Pseudomonas sp., Sphingobacterium multivorum
brenda
Fukuda, M.N.; Matsumura, G.
endo-beta-Galactosidase of Escherichia freundii. Purification and endoglycosidic action on keratan sulfates, oligosaccharides, and blood group active glycoprotein
J. Biol. Chem.
251
6218-6225
1976
Citrobacter freundii
brenda
Tai, G.H.; Huckerby, T.N.; Nieduszynski, A.
N.m.r. spectroscopic studies of fucose-containing oligosaccharides derived from keratanase digestion of articular cartilage keratan sulphates. Influence of fucose residues on keratanase cleavage
Biochem. J.
291
889-894
1993
Pseudomonas sp.
-
brenda
Akhtar, S.; Kerr, B.C.; Hayes, A.J.; Hughes, C.E.; Meek, K.M.; Caterson, B.
Immunochemical localization of keratan sulfate proteoglycans in cornea, sclera, and limbus using a keratanase-generated neoepitope monoclonal antibody
Invest. Ophthalmol. Vis. Sci.
49
2424-2431
2008
Homo sapiens
brenda
Fosang, A.J.; Last, K.; Poon, C.J.; Plaas, A.H.
Keratan sulphate in the interglobular domain has a microstructure that is distinct from keratan sulphate elsewhere on pig aggrecan
Matrix Biol.
28
53-61
2009
Citrobacter freundii
brenda
Kershaw-Young, C.M.; Stuart, C.; Evans, G.; Maxwell, W.M.
The effect of glycosaminoglycan enzymes and proteases on the viscosity of alpaca seminal plasma and sperm function
Anim. Reprod. Sci.
138
261-267
2013
Pseudomonas sp.
brenda