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EC Tree
IUBMB Comments Also hydrolyses S-methyl-L-methionine to dimethyl sulfide and homoserine. cf. EC 3.13.2.3, (R)-S-adenosyl-L-methionine hydrolase (adenosine-forming).
The enzyme appears in viruses and cellular organisms
Synonyms
samase, adometase, s-adenosylmethionine hydrolase, adomet hydrolase, s-adenosyl-l-methionine hydrolase,
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Adenosylmethionine hydrolase
EC 3.3.1.2
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formerly
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hydrolase, adenosylmethionine
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hydrolase, methylmethionine sulfonium salt
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methyl-L-methionine sulfonium salt hydrolase
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methylmethionine sulfonium hydrolase
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methylmethionine sulfonium salt hydrolase
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methylmethionine-sulfonium-salt hydrolase
S-adenosyl-L-methionine hydrolase
S-adenosylmethionine cleaving enzyme
S-adenosylmethionine hydrolase
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Adenosylmethionine hydrolase
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Adenosylmethionine hydrolase
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adenosylmethionine lyase
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adenosylmethionine lyase
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methylmethionine-sulfonium-salt hydrolase
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methylmethionine-sulfonium-salt hydrolase
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S-adenosyl-L-methionine hydrolase
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S-adenosyl-L-methionine hydrolase
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S-adenosylmethionine cleaving enzyme
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S-adenosylmethionine cleaving enzyme
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SAMase
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S-adenosyl-L-methionine + H2O = L-homoserine + S-methyl-5'-thioadenosine
S-adenosyl-L-methionine + H2O = L-homoserine + S-methyl-5'-thioadenosine
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S-adenosyl-L-methionine + H2O = L-homoserine + S-methyl-5'-thioadenosine
when expressed in Escherichia coli, the T3 phage adenosylmethionine hydrolase cleaves S-adenosyl-L-methionine and the metK regulon is induced. In a met repressor (MetJ) deficient backround, induction of the met regulon is even higher
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S-adenosyl-L-methionine + H2O = L-homoserine + S-methyl-5'-thioadenosine
when expressed in Escherichia coli, the T3 phage adenosylmethionine hydrolase cleaves S-adenosyl-L-methionine and the metK regulon is induced. Methylthiodenosine is further cleaved to 5-methylthioribose, which is then exported
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thioether hydrolysis
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S-adenosyl-L-methionine hydrolase (L-homoserine-forming)
Also hydrolyses S-methyl-L-methionine to dimethyl sulfide and homoserine. cf. EC 3.13.2.3, (R)-S-adenosyl-L-methionine hydrolase (adenosine-forming).
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S-adenosyl-L-methionine + H2O
L-homoserine + S-methyl-5'-thioadenosine
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?
S-adenosyl-L-methionine + H2O
methylthioadenosine + L-homoserine
S-adenosyl-L-methionine chloride + H2O
? + L-homoserine
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?
S-adenosyl-L-methionine iodide + H2O
? + L-homoserine
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?
S-methylmethionine + H2O
L-homoserine + dimethylsulfide
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i.e. vitamin U, heat and pH sensitive substrate
dimethylsulfide is volatile and serves as quality marker for cabbage
?
S-adenosyl-L-methionine + H2O
methylthioadenosine + L-homoserine
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?
S-adenosyl-L-methionine + H2O
methylthioadenosine + L-homoserine
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?
S-adenosyl-L-methionine + H2O
methylthioadenosine + L-homoserine
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?
S-adenosyl-L-methionine + H2O
methylthioadenosine + L-homoserine
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?
S-adenosyl-L-methionine + H2O
methylthioadenosine + L-homoserine
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?
S-adenosyl-L-methionine + H2O
methylthioadenosine + L-homoserine
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?
S-adenosyl-L-methionine + H2O
methylthioadenosine + L-homoserine
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?
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S-adenosyl-L-methionine + H2O
L-homoserine + S-methyl-5'-thioadenosine
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?
S-adenosyl-L-methionine + H2O
methylthioadenosine + L-homoserine
S-adenosyl-L-methionine + H2O
methylthioadenosine + L-homoserine
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?
S-adenosyl-L-methionine + H2O
methylthioadenosine + L-homoserine
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?
S-adenosyl-L-methionine + H2O
methylthioadenosine + L-homoserine
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?
S-adenosyl-L-methionine + H2O
methylthioadenosine + L-homoserine
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?
S-adenosyl-L-methionine + H2O
methylthioadenosine + L-homoserine
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?
S-adenosyl-L-methionine + H2O
methylthioadenosine + L-homoserine
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?
S-adenosyl-L-methionine + H2O
methylthioadenosine + L-homoserine
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?
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S-adenosyl-L-homocysteine
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0.2
S-adenosyl-L-methionine
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1.5
S-adenosyl-L-methionine chloride
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3
S-adenosyl-L-methionine iodide
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6 - 8
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pH 6 20% of maximal activity pH 8 90% of maximal activity
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cabbage
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brenda
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brenda
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brenda
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brenda
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ADOM_BPT3
152
0
17035
Swiss-Prot
other Location (Reliability: 5 )
A0A7G9UTC2_9CAUD
152
0
17006
TrEMBL
other Location (Reliability: 4 )
A0A881T428_9CAUD
151
0
17102
TrEMBL
Mitochondrion (Reliability: 5 )
A0A8K0ZV50_9CAUD
Yersinia phage PYps50T
151
0
16987
TrEMBL
Mitochondrion (Reliability: 5 )
A0A7G9UTI5_9CAUD
152
0
16992
TrEMBL
other Location (Reliability: 4 )
A0A218N060_9BACT
87
0
9992
TrEMBL
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A0A8K0ZT27_9CAUD
Yersinia phage PYps49T
151
0
16987
TrEMBL
Mitochondrion (Reliability: 5 )
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5000 - 22000
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3 peaks at 5 kDa, 10 kDa, and 22 kDa, gel filtration
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oligomer
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the structure shows a trimer of alpha-beta sandwiches with active sites formed at the trimer interfaces
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4.5
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stable below
246556
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partial
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expression in Escherichia coli
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expression in Escherichia coli K12
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nutrition
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dimethylsulfide is volatile and serves as quality marker for cabbage
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Mazelis, M.; Levin, B.; Mallinson, N.
Decomposition of methyl methionine sulfonium salts by a bacterial enzyme
Biochim. Biophys. Acta
105
106-114
1965
Corynebacterium sp.
brenda
Spoerel, N.; Herrlich, P.
Colivirus-T3-coded S-adenosylmethionine hydrolase
Eur. J. Biochem.
95
227-233
1979
Enterobacteria phage T3
brenda
Spoerel, N.; Herrlich, P.; Bickle, T.A.
A novel bacteriophage defence mechanism: the anti-restriction protein
Nature
278
30-34
1979
Enterobacteria phage T3
brenda
Hughes, J.A.; Brown, L.R.; Ferro, A.J.
Expression of the cloned coliphage T3 S-adenosylmethionine hydrolase gene inhibits DNA methylation and polyamine biosynthesis in Escherichia coli
J. Bacteriol.
169
3625-3632
1987
Enterobacteria phage T3
brenda
Hughes, J.A.; Brown, L.R.; Ferro, A.J.
Nucleotide sequence and analysis of the coliphage T3 S-adenosylmethionine hydrolase gene and its surrounding ribonuclease III processing sites
Nucleic Acids Res.
15
717-729
1987
Enterobacteria phage T3
brenda
Collier, G.B.; Mattson, T.L.; Connaughton, J.F.; Chirikjian, J.G.
A novel Tn10 tetracycline regulon system controlling expression of the bacteriophage T3 gene encoding S-adenosyl-L-methionine hydrolase
Gene
148
75-80
1994
Enterobacteria phage T3
brenda
Good, X.; Kellogg, J.A.; Wagoner, W.; Langhoff, D.; Matsumura, W.; Bestwick, R.K.
Reduced ethylene synthesis by transgenic tomatoes expressing S-adenosylmethionine hydrolase
Plant Mol. Biol.
26
781-790
1994
Enterobacteria phage T3
brenda
Kramer, M.G.; Kellogg, J.; Wagoner, W.; Matsumura, W.; Good, X.; Peters, S.; Clough, G.; Bestwick, R.K.
Reduced ethylene synthesis and ripening control in tomatoes expressing S-adenosylmethionine hydrolase
Biology and Biotechnology of the Plant Hormone Ethylene (A. K. Kanellis et al. (eds. ))
34
307-319
1997
Enterobacteria phage T3
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brenda
Takigawa, S.; Ishii, G.
Accumulation and decomposition of S-methylmethionine in cabbage
Acta Hortic.
517
457-462
2000
Brassica sp.
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brenda
Hughes, J.A.
In vivo hydrolysis of S-adenosyl-L-methionine in Escherichia coli increases export of 5-methylthioribose
Can. J. Microbiol.
52
599-602
2006
Enterobacteria phage T3
brenda
LaMonte, B.L.; Hughes, J.A.
In vivo hydrolysis of S-adenosylmethionine induces the met regulon of Escherichia coli
Microbiology
152
1451-1459
2006
Enterobacteria phage T3
brenda
Guo, X.; Soederholm, A.; Kanchugal, S.P.; Isaksen, G.V.; Warsi, O.; Eckhard, U.; Trigis, S.; Gogoll, A.; Jerlstroem-Hultqvist, J.; Aqvist, J.; Andersson, D.I.; Selmer, M.
Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family
Elife
10
e61818
2021
Enterobacteria phage T3
brenda
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3.13.2.2 S-adenosyl-L-methionine hydrolase (L-homoserine-forming)
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