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Disease on EC 3.1.99.B1 - flap endonuclease-1

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
A conserved tyrosine residue aids ternary complex formation, but not catalysis, in phage T5 flap endonuclease.
Adenomatous Polyposis Coli
Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function.
Interaction between APC and Fen1 during breast carcinogenesis.
Ataxia Telangiectasia
Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?
Bloom Syndrome
Stimulation of flap endonuclease-1 by the Bloom's syndrome protein.
The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA.
Breast Neoplasms
Artichoke Polyphenols Sensitize Human Breast Cancer Cells to Chemotherapeutic Drugs via a ROS-Mediated Downregulation of Flap Endonuclease 1.
Curcumin increases breast cancer cell sensitivity to cisplatin by decreasing FEN1 expression.
Curcumin inhibits proliferation of breast cancer cells through Nrf2-mediated down-regulation of Fen1 expression.
FEN1 gene variants confer reduced risk of breast cancer in chinese women: A case-control study.
FEN1 is a prognostic biomarker for ER+ breast cancer and associated with tamoxifen resistance through the ER?/cyclin D1/Rb axis.
Identification of Flap Endonuclease 1 With Diagnostic and Prognostic Value in Breast Cancer.
Interaction between APC and Fen1 during breast carcinogenesis.
Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?
Letrozole improves the sensitivity of breast cancer cells overexpressing aromatase to cisplatin via down-regulation of FEN1.
Targeting DNA Flap Endonuclease 1 to Impede Breast Cancer Progression.
The interaction effects of FEN1 rs174538 polymorphism and polycyclic aromatic hydrocarbon exposure on damage in exon 19 and 21 of EGFR gene in coke oven workers.
Carcinogenesis
Association between FEN1 Polymorphisms -69G>A and 4150G>T with Susceptibility in Human Disease: A Meta-Analysis.
Association between the flap endonuclease 1 gene polymorphisms and cancer susceptibility: An updated meta-analysis.
Flap endonuclease 1 polymorphisms (rs174538 and rs4246215) contribute to an increased cancer risk: Evidence from a meta-analysis.
Functional FEN1 genetic variants contribute to risk of hepatocellular carcinoma, esophageal cancer, gastric cancer and colorectal cancer.
Functional FEN1 polymorphisms are associated with DNA damage levels and lung cancer risk.
The Association of Flap Endonuclease 1 Genotypes with the Risk of Childhood Leukemia.
Carcinoma
Flap endonuclease-1 rs174538 G>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population.
Carcinoma, Ductal
The prognostic significance of Flap Endonuclease 1 (FEN1) in breast ductal carcinoma in situ.
Carcinoma, Hepatocellular
Identification of Flap endonuclease 1 as a potential core gene in hepatocellular carcinoma by integrated bioinformatics analysis.
TGF?1- miR-140-5p axis mediated up-regulation of Flap Endonuclease 1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma.
Carcinoma, Intraductal, Noninfiltrating
The prognostic significance of Flap Endonuclease 1 (FEN1) in breast ductal carcinoma in situ.
Cockayne Syndrome
Repair of persistent strand breaks in the mitochondrial genome.
Colonic Neoplasms
Discovery of Myricetin as a Potent Inhibitor of Human Flap Endonuclease 1, Which Potentially Can Be Used as Sensitizing Agent against HT-29 Human Colon Cancer Cells.
Colorectal Neoplasms
An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development.
Corneal Dystrophies, Hereditary
Polymorphism of the flap endonuclease 1 gene in keratoconus and Fuchs endothelial corneal dystrophy.
Endometriosis
The Association of Flap Endonuclease 1 Genotypes with the Susceptibility of Endometriosis.
Esophageal Neoplasms
Flap endonuclease-1 rs174538 G>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population.
Esophageal Squamous Cell Carcinoma
Flap endonuclease-1 rs174538 G>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population.
Fanconi Anemia
Human Fanconi anemia complementation group a protein stimulates the 5' flap endonuclease activity of FEN1.
Fuchs' Endothelial Dystrophy
Polymorphism of the flap endonuclease 1 gene in keratoconus and Fuchs endothelial corneal dystrophy.
Gallbladder Neoplasms
Variants and haplotypes in Flap endonuclease 1 and risk of gallbladder cancer and gallstones: a population-based study in China.
Gallstones
Variants and haplotypes in Flap endonuclease 1 and risk of gallbladder cancer and gallstones: a population-based study in China.
Hepatitis B
Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus.
The cooperative complex of Argonaute-2 and microRNA-146a regulates hepatitis B virus replication through flap endonuclease 1.
Hypersensitivity
Complementary roles for exonuclease 1 and Flap endonuclease 1 in maintenance of triplet repeats.
Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner.
Keratoconus
Polymorphism of the flap endonuclease 1 gene in keratoconus and Fuchs endothelial corneal dystrophy.
Leukemia
The Association of Flap Endonuclease 1 Genotypes with the Risk of Childhood Leukemia.
Lung Neoplasms
FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer.
Increased expression and no mutation of the Flap endonuclease (FEN1) gene in human lung cancer.
Lung cancer: progression of heat shock protein 70 in association with flap endonuclease 1 protein.
Overexpression of Flap Endonuclease 1 Correlates with Enhanced Proliferation and Poor Prognosis of Non-Small-Cell Lung Cancer.
Malaria
Affen, Menschen und Malaria. Affenmalaria - auch für den Menschen gefährlich!
Myotonic Dystrophy
Fen1 does not control somatic hypermutability of the (CTG)(n).(CAG)(n) repeat in a knock-in mouse model for DM1.
Neoplasms
Association between the flap endonuclease 1 gene polymorphisms and cancer susceptibility: An updated meta-analysis.
Cancer Biomarker-Triggered Disintegrable DNA Nanogels for Intelligent Drug Delivery.
Chemical-induced cancer incidence and underlying mechanisms in Fen1 mutant mice.
FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination.
FEN1 is a prognostic biomarker for ER+ breast cancer and associated with tamoxifen resistance through the ER?/cyclin D1/Rb axis.
Flap endonuclease 1 (FEN1) as a novel diagnostic and prognostic biomarker for gastric cancer.
Flap endonuclease 1 polymorphisms (rs174538 and rs4246215) contribute to an increased cancer risk: Evidence from a meta-analysis.
Flap endonuclease 1: a novel tumour suppresser protein.
Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner.
Flap endonuclease 1 silencing is associated with increasing the cisplatin sensitivity of SGC?7901 gastric cancer cells.
Fluorometric detection of cancer marker FEN1 based on double-flapped dumbbell DNA nanoprobe functionalized with silver nanoclusters.
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression.
Inhibition of AKT sensitizes cancer cells to antineoplastic drugs by down-regulating Flap Endonuclease 1.
Interacting partners of FEN1 and its role in the development of anticancer therapeutics.
Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?
Jianpi-yangwei decoction inhibits DNA damage repair in the drug resistance of gastric cancer by reducing FEN1 expression.
Lung cancer: progression of heat shock protein 70 in association with flap endonuclease 1 protein.
MicroRNA-140 impedes DNA repair by targeting FEN1 and enhances chemotherapeutic response in breast cancer.
Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair.
Overexpression and hypomethylation of flap endonuclease 1 gene in breast and other cancers.
Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Precision Spherical Nucleic Acids Enable Sensitive FEN1 Imaging and Controllable Drug Delivery for Cancer-Specific Therapy.
TGF?1- miR-140-5p axis mediated up-regulation of Flap Endonuclease 1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma.
The Association of Flap Endonuclease 1 Genotypes with the Susceptibility of Endometriosis.
The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers.
Upregulation of FEN1 Is Associated with the Tumor Progression and Prognosis of Hepatocellular Carcinoma.
YY1 suppresses FEN1 over-expression and drug resistance in breast cancer.
[Flap endonuclease-1 and its role in the processes of DNA metabolism in eucaryotic cells]
Ovarian Neoplasms
Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer.
Prostatic Neoplasms
Flap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason score.
Stomach Neoplasms
Flap endonuclease 1 (FEN1) as a novel diagnostic and prognostic biomarker for gastric cancer.
Flap endonuclease 1 is a promising candidate biomarker in gastric cancer and is involved in cell proliferation and apoptosis.
Jianpi-yangwei decoction inhibits DNA damage repair in the drug resistance of gastric cancer by reducing FEN1 expression.
Vitelliform Macular Dystrophy
cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid.
Werner Syndrome
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity.
Xeroderma Pigmentosum
Control of structure-specific endonucleases to maintain genome stability.
FEN1 participates in repair of the 5'-phosphotyrosyl terminus of DNA single-strand breaks.