Disease on EC 3.1.99.B1 - flap endonuclease-1
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Acquired Immunodeficiency Syndrome
A conserved tyrosine residue aids ternary complex formation, but not catalysis, in phage T5 flap endonuclease.
Adenomatous Polyposis Coli
Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function.
Ataxia Telangiectasia
Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?
Bloom Syndrome
The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA.
Breast Neoplasms
Artichoke Polyphenols Sensitize Human Breast Cancer Cells to Chemotherapeutic Drugs via a ROS-Mediated Downregulation of Flap Endonuclease 1.
Breast Neoplasms
Curcumin increases breast cancer cell sensitivity to cisplatin by decreasing FEN1 expression.
Breast Neoplasms
Curcumin inhibits proliferation of breast cancer cells through Nrf2-mediated down-regulation of Fen1 expression.
Breast Neoplasms
FEN1 gene variants confer reduced risk of breast cancer in chinese women: A case-control study.
Breast Neoplasms
FEN1 is a prognostic biomarker for ER+ breast cancer and associated with tamoxifen resistance through the ER?/cyclin D1/Rb axis.
Breast Neoplasms
Identification of Flap Endonuclease 1 With Diagnostic and Prognostic Value in Breast Cancer.
Breast Neoplasms
Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?
Breast Neoplasms
Letrozole improves the sensitivity of breast cancer cells overexpressing aromatase to cisplatin via down-regulation of FEN1.
Breast Neoplasms
The interaction effects of FEN1 rs174538 polymorphism and polycyclic aromatic hydrocarbon exposure on damage in exon 19 and 21 of EGFR gene in coke oven workers.
Carcinogenesis
Association between FEN1 Polymorphisms -69G>A and 4150G>T with Susceptibility in Human Disease: A Meta-Analysis.
Carcinogenesis
Association between the flap endonuclease 1 gene polymorphisms and cancer susceptibility: An updated meta-analysis.
Carcinogenesis
Flap endonuclease 1 polymorphisms (rs174538 and rs4246215) contribute to an increased cancer risk: Evidence from a meta-analysis.
Carcinogenesis
Functional FEN1 genetic variants contribute to risk of hepatocellular carcinoma, esophageal cancer, gastric cancer and colorectal cancer.
Carcinogenesis
Functional FEN1 polymorphisms are associated with DNA damage levels and lung cancer risk.
Carcinogenesis
The Association of Flap Endonuclease 1 Genotypes with the Risk of Childhood Leukemia.
Carcinoma
Flap endonuclease-1 rs174538 G>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population.
Carcinoma, Ductal
The prognostic significance of Flap Endonuclease 1 (FEN1) in breast ductal carcinoma in situ.
Carcinoma, Hepatocellular
Identification of Flap endonuclease 1 as a potential core gene in hepatocellular carcinoma by integrated bioinformatics analysis.
Carcinoma, Hepatocellular
TGF?1- miR-140-5p axis mediated up-regulation of Flap Endonuclease 1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma.
Carcinoma, Intraductal, Noninfiltrating
The prognostic significance of Flap Endonuclease 1 (FEN1) in breast ductal carcinoma in situ.
Colonic Neoplasms
Discovery of Myricetin as a Potent Inhibitor of Human Flap Endonuclease 1, Which Potentially Can Be Used as Sensitizing Agent against HT-29 Human Colon Cancer Cells.
Colorectal Neoplasms
An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development.
Corneal Dystrophies, Hereditary
Polymorphism of the flap endonuclease 1 gene in keratoconus and Fuchs endothelial corneal dystrophy.
Endometriosis
The Association of Flap Endonuclease 1 Genotypes with the Susceptibility of Endometriosis.
Esophageal Neoplasms
Flap endonuclease-1 rs174538 G>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population.
Esophageal Squamous Cell Carcinoma
Flap endonuclease-1 rs174538 G>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population.
Fanconi Anemia
Human Fanconi anemia complementation group a protein stimulates the 5' flap endonuclease activity of FEN1.
Fuchs' Endothelial Dystrophy
Polymorphism of the flap endonuclease 1 gene in keratoconus and Fuchs endothelial corneal dystrophy.
Gallbladder Neoplasms
Variants and haplotypes in Flap endonuclease 1 and risk of gallbladder cancer and gallstones: a population-based study in China.
Gallstones
Variants and haplotypes in Flap endonuclease 1 and risk of gallbladder cancer and gallstones: a population-based study in China.
Hepatitis B
The cooperative complex of Argonaute-2 and microRNA-146a regulates hepatitis B virus replication through flap endonuclease 1.
Hypersensitivity
Complementary roles for exonuclease 1 and Flap endonuclease 1 in maintenance of triplet repeats.
Hypersensitivity
Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner.
Keratoconus
Polymorphism of the flap endonuclease 1 gene in keratoconus and Fuchs endothelial corneal dystrophy.
Leukemia
The Association of Flap Endonuclease 1 Genotypes with the Risk of Childhood Leukemia.
Lung Neoplasms
FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer.
Lung Neoplasms
Increased expression and no mutation of the Flap endonuclease (FEN1) gene in human lung cancer.
Lung Neoplasms
Lung cancer: progression of heat shock protein 70 in association with flap endonuclease 1 protein.
Lung Neoplasms
Overexpression of Flap Endonuclease 1 Correlates with Enhanced Proliferation and Poor Prognosis of Non-Small-Cell Lung Cancer.
Myotonic Dystrophy
Fen1 does not control somatic hypermutability of the (CTG)(n).(CAG)(n) repeat in a knock-in mouse model for DM1.
Neoplasms
Association between the flap endonuclease 1 gene polymorphisms and cancer susceptibility: An updated meta-analysis.
Neoplasms
Cancer Biomarker-Triggered Disintegrable DNA Nanogels for Intelligent Drug Delivery.
Neoplasms
FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination.
Neoplasms
FEN1 is a prognostic biomarker for ER+ breast cancer and associated with tamoxifen resistance through the ER?/cyclin D1/Rb axis.
Neoplasms
Flap endonuclease 1 (FEN1) as a novel diagnostic and prognostic biomarker for gastric cancer.
Neoplasms
Flap endonuclease 1 polymorphisms (rs174538 and rs4246215) contribute to an increased cancer risk: Evidence from a meta-analysis.
Neoplasms
Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner.
Neoplasms
Flap endonuclease 1 silencing is associated with increasing the cisplatin sensitivity of SGC?7901 gastric cancer cells.
Neoplasms
Fluorometric detection of cancer marker FEN1 based on double-flapped dumbbell DNA nanoprobe functionalized with silver nanoclusters.
Neoplasms
Inhibition of AKT sensitizes cancer cells to antineoplastic drugs by down-regulating Flap Endonuclease 1.
Neoplasms
Interacting partners of FEN1 and its role in the development of anticancer therapeutics.
Neoplasms
Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?
Neoplasms
Jianpi-yangwei decoction inhibits DNA damage repair in the drug resistance of gastric cancer by reducing FEN1 expression.
Neoplasms
Lung cancer: progression of heat shock protein 70 in association with flap endonuclease 1 protein.
Neoplasms
MicroRNA-140 impedes DNA repair by targeting FEN1 and enhances chemotherapeutic response in breast cancer.
Neoplasms
Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair.
Neoplasms
Overexpression and hypomethylation of flap endonuclease 1 gene in breast and other cancers.
Neoplasms
Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Neoplasms
Precision Spherical Nucleic Acids Enable Sensitive FEN1 Imaging and Controllable Drug Delivery for Cancer-Specific Therapy.
Neoplasms
TGF?1- miR-140-5p axis mediated up-regulation of Flap Endonuclease 1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma.
Neoplasms
The Association of Flap Endonuclease 1 Genotypes with the Susceptibility of Endometriosis.
Neoplasms
The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers.
Neoplasms
Upregulation of FEN1 Is Associated with the Tumor Progression and Prognosis of Hepatocellular Carcinoma.
Neoplasms
[Flap endonuclease-1 and its role in the processes of DNA metabolism in eucaryotic cells]
Ovarian Neoplasms
Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer.
Prostatic Neoplasms
Flap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason score.
Stomach Neoplasms
Flap endonuclease 1 (FEN1) as a novel diagnostic and prognostic biomarker for gastric cancer.
Stomach Neoplasms
Flap endonuclease 1 is a promising candidate biomarker in gastric cancer and is involved in cell proliferation and apoptosis.
Stomach Neoplasms
Jianpi-yangwei decoction inhibits DNA damage repair in the drug resistance of gastric cancer by reducing FEN1 expression.
Vitelliform Macular Dystrophy
cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid.
Werner Syndrome
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity.
Xeroderma Pigmentosum
Control of structure-specific endonucleases to maintain genome stability.
Xeroderma Pigmentosum
FEN1 participates in repair of the 5'-phosphotyrosyl terminus of DNA single-strand breaks.
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