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(R)-1-[(4-cyanophenyl)(3-bromo-4-sulfamoyloxyphenyl)methyl]-1H-[1,2,4]triazole
pure R(+)-enantiomer of 1-[(4-Cyanophenyl)(3-bromo-4-sulfamoyloxyphenyl)methyl]-1H-[1,2,4]triazole
(S)-1-[(4-cyanophenyl)(3-bromo-4-sulfamoyloxyphenyl)methyl]-1H-[1,2,4]triazole
pure S(-)-enantiomer of 1-[(4-Cyanophenyl)(3-bromo-4-sulfamoyloxyphenyl)methyl]-1H-[1,2,4]triazole
1-[(4-cyanophenyl)(3-bromo-4-sulfamoyloxyphenyl)methyl]-1H-[1,2,4]triazole
bromo derivative of 1-[(4-cyanophenyl)(3-chloro-4-sulfamoyloxyphenyl)methyl]-1H-[1,2,4]triazole does improve aromatase inhibitory activity
1-[(4-cyanophenyl)(3-chloro-4-sulfamoyloxyphenyl)methyl]-1H-[1,2,4]triazole
meta-chloro derivative of 1-[(4-cyanophenyl)(4-sulfamoyloxyphenyl)methyl]-1H-[1,2,4]triazole does increase aromatase inhibition activity
1-[(4-cyanophenyl)(4-sulfamoyloxyphenyl)methyl]-1H-[1,2,4]triazole
increase of aromatase inhibitory activity due to presence of a para-cyanophenyl moiety
1-[bis-(3-bromo-4-sulfamoyloxyphenyl)methyl]-1H-[1,2,4]triazole
best dual inhibition
1-[bis-(3-sulfamoyloxy-4-methoxyphenyl)methyl]-1H-[1,2,4]triazole
methoxy groups reduce inhibition of aromatase compared to 1-[bis-(3-sulfamoyloxyphenyl)methyl]-1H-[1,2,4]triazole
1-[bis-(3-sulfamoyloxyphenyl)methyl]-1H-[1,2,4]triazole
sulfamate in meta-position increases aromatase inhibition strength compared to para-position
1-[bis-(4-sulfamoyloxy-3-methoxyphenyl)methyl]-1H-[1,2,4]triazole
exchange in positions of methoxy and sulfamate group compared to 1-[bis-(3-sulfamoyloxy-4-methoxyphenyl)methyl]-1H-[1,2,4]triazole fails to improve aromatase inhibitory activity
2-chloro-4-[5-(2,6-difluoro-3-hydroxybenzoyl)thiophen-2-yl]phenyl sulfamate
dual inhibitor, acts both on STS and hydroxy steroid dehydrogenase 17beta-HSD1, reverses estrogen-induced T-47D cell proliferation
3-sulfamoyloxy-N-3,3,3-trifluoropropyl-16,17-seco-estra-1,3,4(10)-triene-16,17-imide
highly potent, long-acting, nonestrogenic steroid sulfatase inhibitor with inhibitory properties to human carbonic anhydrase II, thus enabling transport by erythorcytes, no estrogenic effects observed in uterine weight gain study with ovariectomized Wistar rats, 24 h after last dose of 4 days of oral administration of 10 mg/kg/d, in vivo: single dose of 0.1 mg/kg 48% inhibition of liver steroid sulfatase activity, 0.5 and 1 mg/kg total inhibition, activity measured 24 h after dose administration, recovery of steroid sulfatase acitivity after single oral dose of 10 mg/kg: complete inhibition till day 5, day 17: 50% recovery, day 28: complete recovery
3-[4-(3,4-difluoro-benzoylamino)-phenyl]-coumarin-7-O-sulfamate
compound exhibits poor cytotoxicity
3-[4-[2-(2,5-bis-trifluoromethyl-phenyl)-acetylamino]-phenyl]-coumarin-7-O-sulfamate
compound shows antiproliferative activity against the MCF-7 and T47D cell lines, GI50 value is 15.9 microM and 8.7 microM, respectively
4-(cyclohexanecarboxamido)phenyl sulfamate
55.7% inhibition of isolated enzyme at 0.01 mM, 86.1% inhibition of the STS activity of JEG-3 carcinoma cells at 0.010 mM
4-fluoro-17beta-(3'-trifluoromethylbenzene)sulfonamideestra-1,3,5(10)-trien-3-ol
-
4-nitro-17beta-4'-biphenylsulfonamide-1,3,5(10)-estratrien-3-ol
-
dexamethasone
inhibits STS activity and expression in undifferentiated cells, the glucocorticoid antagonist RU486 reverses dexamethasone inhibition of STS
Fe2+
10 mM, about 40% of initial activity
STX213
highly potent, long-acting, nonestrogenic steroid sulfatase inhibitor with inhibitory properties to human carbonic anhydrase II, thus enabling transport by erythorcytes, no estrogenic effects observed in uterine weight gain study with ovariectomized Wistar rats, 24 h after last dose of 4 days of oral administration of 10 mg/kg/d, in vivo: single dose of 0.1 mg/kg 25% inhibition of liver steroid sulfatase activity, 0.5 and 1 mg/kg total inhibition, activity measured 24 h after dose administration, recovery of steroid sulfatase acitivity after single oral dose of 10 mg/kg: complete inhibition till day 4, day 12: 50% recovery, day 15: almost complete recovery
STX64
synonym BN83495, irreversible inhibition, STS inhibitor property within dual aromatase-sulfatase inhibitor, letrozole reversible cytochrome P450 enzyme aromatase inhibitor serves as aromatase inhibiting component
Zn2+
10 mM, loss of activity
(12aS)-N,N-dihydroxy-12a-methyl-1,3-dioxo-2-propyl-1,2,3,4,4a,4b,5,6,10b,11,12,12a-dodecahydronaphtho[2,1-f]isoquinoline-8-sulfinamide
-
-
(17beta)-17-(2,3,4,5,6-pentafluorobenzyl)-estra-1(10),2,4-triene-3,17-diol
-
-
(17beta)-17-(2-furylmethyl)-estra-1(10),2,4-triene-3,17-diol
-
-
(17beta)-17-(3,5-dibromobenzyl)-estra-1(10),2,4-triene-3,17-diol
-
-
(17beta)-17-(3-benzyloxybenzyl)-estra-1(10),2,4-triene-3,17-diol
-
-
(17beta)-17-(3-bromobenzyl)-estra-1(10),2,4-triene-3,17-diol
-
-
(17beta)-17-(3-iodobenzyl)-estra-1(10),2,4-triene-3,17-diol
-
-
(17beta)-17-(3-tert-butylbenzyl)-estra-1(10),2,4-triene-3,17-diol
-
-
(17beta)-17-(3-trifluoromethylbenzyl)-estra-1(10),2,4-triene-3,17-diol
-
-
(17beta)-17-(4-bromobenzyl)-estra-1(10),2,4-triene-3,17-diol
-
-
(17beta)-17-(4-iodobenzyl)-estra-1(10),2,4-triene-3,17-diol
-
-
(17beta)-17-(4-methyl-2-thienyl)-estra-1(10),2,4-triene-3,17-diol
-
-
(17beta)-17-(4-tert-butylbenzyl)-estra-1(10),2,4-triene-3,17-diol
-
-
(17beta)-17-(4-tert-butylbenzyl)estra-1(10),2,4-triene-3,17-diol
-
estradiol phenolic reversible inhibitor as reference, possible additional breast cancer therapy, no inhibition at 0.01 microM, at 0.1 microM 39% inhibition, at 1 microM 62% inhibition
(17beta)-17-(4-trifluoromethylbenzyl)-estra-1(10),2,4-triene-3,17-diol
-
-
(17beta)-17-(cyclohexylmethyl)-estra-1(10),2,4-triene-3,17-diol
-
-
(17beta)-17-(cyclopropylmethyl)-estra-1(10),2,4-triene-3,17-diol
-
-
(17beta)-17-(pyridin-3-ylmethyl)-estra-1(10),2,4-triene-3,17-diol
-
-
(17beta)-17-benzyl-estra-1(10),2,4-triene-3,17-diol
-
-
(17beta)-17-benzylestra-1(10),2,4-triene-3,17-diol
-
estradiol phenolic reversible inhibitor as reference, possible additional breast cancer therapy, no inhibition at 0.01 microM, at 0.1 microM 15% inhibition, at 1 microM 48% inhibition
(17beta)-17-[3,5-bis(benzyloxy)benzyl]-estra-1(10),2,4-triene-3,17-diol
-
-
(17beta)-17-[3,5-bis(tert-butyl)benzyl]-estra-1(10),2,4-triene-3,17-diol
-
-
(17beta)-17-[3,5-bis(trifluoromethyl)benzyl]-estra-1(10),2,4-triene-3,17-diol
-
-
(17beta)-17-[3-(dibenzylamino)benzyl]-estra-1(10),2,4-triene-3,17-diol
-
-
(17beta)-17-[4-(benzyloxy)benzyl]-estra-1(10),2,4-triene-3,17-diol
-
-
(17beta)-17-{[2-(2-bromoethyl)cyclopropyl]methyl}estra-1(10),2,4-triene-3,17-diol
-
-
(17beta,17'beta)-17,17'-(2E)-but-2-ene-1,4-diylbisestra-1(10),2,4-triene-3,17-diol
-
reversible non-competitive or mixed inhibition, estradiol dimer with C17-C17 bond, possible additional breast cancer therapy, no inhibition at 0.01 microM, at 0.1 microM 42% inhibition, at 1 microM 56% inhibition
(17beta,17'beta)-17,17'-butane-1,4-diylbisestra-1(10),2,4-triene-3,17-diol
-
reversible non-competitive or mixed inhibition, estradiol dimer with C17-C17 bond, possible additional breast cancer therapy, no inhibition at 0.01 microM, at 0.1 microM 30% inhibition, at 1 microM 54% inhibition
(2-(1-adamantyl)-4-oxo-4H-chromen-6-yl)(oxo)acetic acid
-
-
(2-(1-adamantyl)-4-oxo-4H-chromen-6-yl)acetic acid
-
-
(p-O-sulfamoyl)-N-tetradecanoyl tyramine
-
non-estrogenic STS inhibitor, IC50: 56 nM/l, anti-cancer activity
1-indanone 4-O-sulfamate
-
-
1-indanone 5-O-sulfamate
-
-
1-indanone 6-O-sulfamate
-
-
1-tetralone 6-O-sulfamate
-
-
1-tetralone 7-O-sulfamate
-
-
16alpha-hydroxydehydroepiandrosterone
-
competitive to dihydroepiandrosterone
17alpha-benzyl-17beta-hydroxyestra-1,3,5-(10)-triene-3-boronic acid
-
-
17alpha-benzyl-3,17beta-dihydroxyestra-1,3,5-(10)-triene
-
-
17beta estradiol
-
exposure to 17beta estradiol causes 70% reduction of estrone 3-sulfate sulfatase activity in MCF-7 cells after 6 days, but 9% increase in mammary myoepithelial cells
19,19-difluoro-17-oxo-4,9-cyclo-9,10-secoandrosta-1,3,5(10)-trien-1-yl hydrogen sulfate
-
-
19-fluoro-17-oxo-4,9-cyclo-9,10-secoandrosta-1,3,5(10)-trien-1-yl hydrogen sulfate
-
-
2',4'-dicyano-N,N-dihydroxybiphenyl-4-sulfinamide
-
-
2-(1-adamantyl)-4-oxo-4H-chromen-6-yl sulfamate
-
-
2-(1-adamantyl)-4-oxo-4H-chromene-6-carbaldehyde
-
-
2-(1-adamantyl)-4-oxo-4H-chromene-6-carboxamide
-
-
2-(1-adamantyl)-4-oxo-4H-chromene-6-carboxylic acid
-
-
2-(1-adamantyl)-4-oxo-4H-thiochromen-6-yl sulfamate
-
-
2-(1-adamantyl)-4-oxo-4H-thiochromene-6-carbonitrile
-
-
2-(1-adamantyl)-4-oxo-4H-thiochromene-6-carboxylic acid
-
-
2-(1-adamantyl)-6-(hydroxymethyl)-4H-chromen-4-one
-
-
2-(1-adamantyl)-6-glycoloyl-4H-chromen-4-one
-
-
2-(difluoromethyl)-17-oxoestra-1(10),2,4-trien-3-yl hydrogen sulfate
-
-
2-(fluoromethyl)-17-oxoestra-1(10),2,4-trien-3-yl hydrogen sulfate
-
-
2-bromo-4-[(R)-(4-cyanophenyl)(1H-1,2,4-triazol-1-yl)methyl]-N,N-dihydroxybenzenesulfinamide
-
-
2-formyl-17alpha-benzyl-17beta-hydroxyestra-1,3,5(10)-triene
-
time- and concentration-dependent inhibitor, shows more or less pseudo-first order behavior at all concentrations
2-methoxy-6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate
-
-
2-methoxyestrone-3-O-sulfamate
-
potent active site-directed inhibitor, no effect on STS mRNA expression in fibroblasts
2-phenylindole sulfamate
-
2-phenylindole sulfamates with lipophilic side chains in 1- or 5-position of the indole with IC50-values between 2 nM and 0.001 mM, irreversibly inhibits hydrolysis of estrone sulfate in MDA-MB 231 cells, inhibits gene activation in estrogen receptor-positive MCF-7 breast cancer cells in submicromolar concentrations and reduces cell proliferation with IC50 of 0.001 mM
2-t-butyl-4H-1-benzopyran-4-one-6-boronic acid
-
-
2-tert-butyl-6-hydroxy-4H-chromen-4-one
-
-
2-[3-[[(4-[[(aminooxy)sulfinyl]oxy]phenyl)sulfanyl]methyl]-5-(1H-1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile
-
-
2H1-benzpyran 7-O-disulfamate
-
-
3'-((1H-1,2,4-triazol-1-yl)methyl)-3-chloro-4'-cyanobiphenyl-4-yl sulfamate
-
-
3'-((1H-1,2,4-triazol-1-yl)methyl)-3-chloro-5'-(2-cyanopropan-2-yl)biphenyl-4-yl sulfamate
-
68.2% inhibition at 0.01 mM
3'-((1H-1,2,4-triazol-1-yl)methyl)-3-chloro-5'-cyanobiphenyl-4-yl sulfamate
-
-
3'-((1H-1,2,4-triazol-1-yl)methyl)-3-chlorobiphenyl-4-yl sulfamate
-
-
3'-((1H-1,2,4-triazol-1-yl)methyl)-4'-cyanobiphenyl-4-yl sulfamate
-
-
3'-((1H-1,2,4-triazol-1-yl)methyl)biphenyl-4-yl sulfamate
-
-
3'-chloro-5-(1H-1,2,4-triazol-1-ylmethyl)biphenyl-2-carbonitrile
-
-
3,4,8-trimethylcoumarin 7-O-sulfamate
-
-
3,4-dihydro-4-methylcoumarin 7-O-sulfamate
-
-
3,4-dihydrocoumarin 7-O-sulfamate
-
-
3,4-dimethylcoumarin 7-O-sulfate
-
12-fold more potent than COUMATE
3-benzyl-4-methylcoumarin-7-O-sulfamate
-
IC50 value 0.68 nM in intact MCF-7 cells
3-hexyl-4-methylcoumarin-7-O-sulfamate
-
IC50 value 0.68 nM in intact MCF-7 cells
3-oxo-1,3-dihydro-2H-cyclobuta[c]chromen-6-yl sulfamate
-
-
4'-((1H-1,2,4-triazol-1-yl)methyl)-2'-cyanobiphenyl-4-yl sulfamate
-
-
4'-((1H-1,2,4-triazol-1-yl)methyl)-3-chloro-2'-cyanobiphenyl-4-yl sulfamate
-
-
4-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)-2-methoxyphenyl sulfamate
-
-
4-(trifluoromethyl)coumarin 7-O-sulfamate
-
-
4-fluoro-17alpha-benzyl-17beta-hydroxyestra-1,3,5(10)-triene
-
linear mixed-type inhibition, compound is capable of binding at sites both within and outside the active site
4-methylcoumarin 6,7-O,O-disulfamate
-
-
4-methylcoumarin 7-O-sulfamate
-
COUMATE, also in vivo
4-oxo-1,2,3,4-tetrahydrocyclopenta[c]chromen-7-yl sulfamate
-
-
5'-((1H-1,2,4-triazol-1-yl)methyl)-2'-cyanobiphenyl-4-yl sulfamate
-
-
5'-((1H-1,2,4-triazol-1-yl)methyl)-3-chloro-2'-cyanobiphenyl-4-yl sulfamate
-
-
5,6,7,8-tetrahydronaphthalene 2-O-(N,N-dimethyl)sulfamate
-
-
5,6,7,8-tetrahydronaphthalene 2-O-(N-methyl)sulfamate
-
-
5,6,7,8-tetrahydronaphthalene 2-O-sulfamate
-
-
5-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)-2-methoxyphenyl sulfamate
-
-
5-((1H-1,2,4-triazol-1-yl)methyl)-3'-chloro-4'-hydroxybiphenyl-2-carbonitrile
-
-
5-((1H-1,2,4-triazol-1-yl)methyl)-4'-hydroxybiphenyl-2-carbonitrile
-
-
5-methyl-6-oxo-6,7,8,9,10,11-hexahydro-5H-cyclohepta[c]quinolin-3-yl sulfamate
-
-
5-pregnen-3beta,21-diol
-
most potent inhibitor of C21 steroids
5-pregnen-3beta,21-diol-20-one
-
most potent inhibitor of C21 steroids
5alpha-androstane-3alpha-17beta-diol
-
most potent inhibitor of C19 steroids
6-(3-phenylpropoxy)-8,9,10,11-tetrahydro-7H-cyclohepta[c]quinolin-3-yl sulfamate
-
-
6-(pentyloxy)-8,9,10,11-tetrahydro-7H-cyclohepta[c]quinolin-3-yl sulfamate
-
-
6-methoxy-8,9,10,11-tetrahydro-7H-cyclohepta[c]quinolin-3-yl sulfamate
-
-
6-methoxycoumarin 7-O-sulfamate
-
-
6-oxo-5-(3-phenylpropyl)-6,7,8,9,10,11-hexahydro-5H-cyclohepta[c]quinolin-3-yl sulfamate
-
-
6-oxo-5-pentyl-6,7,8,9,10,11-hexahydro-5H-cyclohepta[c]quinolin-3-yl sulfamate
-
-
6-oxo-6,7,8,9,10,11,12,13,14,15,16,17,18,19-tetradecahydrocyclopentadeca[c]chromen-3-yl sulfamate
-
-
6-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydrocyclotrideca[c]chromen-3-yl sulfamate
-
-
6-oxo-6,7,8,9,10,11,12,13,14,15-decahydrocycloundeca[c]chromen-3-yl sulfamate
-
-
6-oxo-6,7,8,9,10,11,12,13-octahydrocyclonona[c]chromen-3-yl sulfamate
-
-
6-oxo-6,7,8,9,10,11-hexahydro-5H-cyclohepta[c]quinolin-3-yl sulfamate
-
-
6-oxo-6,7,8,9,10,11-hexahydro-5H-cyclohepta[c]quinolin-3-ylsulfamide
-
-
6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-2-yl sulfamate
-
-
6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl dimethylsulfamate
-
-
6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate
-
-
6-oxo-7,8,9,10,11,12,13,14,15,16-decahydro-6H-cyclododeca[c]-chromen-3-yl sulfamate
-
-
6-oxo-7,8,9,10,11,12,13,14-octahydro-6H-cyclodeca[c]chromen-3-yl sulfamate
-
-
6-oxo-7,8,9,10,11,12-hexahydro-6H-cycloocta[c]chromen-3-yl sulfamate
-
i.e. STW64, treatment of postmenopausal women with estrogen receptor-positive metastatic breast cancer. Inhibitor almost completely blocks enzyme activity in peripheral blood lymphocytes and tumor tissues, inhibition is associated with significant reductions in serum concentrations of androstenediol and estrogens. Serum androstenedione concentration also decreases by up to 86%
6-oxo-7,8,9,10-tetrahydro-6H-benzo[c]chromen-3-yl sulfamate
-
-
6-oxo-8,9,10,11-tetrahydro-7H-cyclohepta-[c][1]benzopyran-3-O-sulfamate
-
6,6,7-COUMATE, IC50: 5.1 nM in JEG-3 cells, 0.43 nM in MCF-7 cells
6-oxo-8,9,10,11-tetrahydro-7H-cylohepta-[c][1]benzopyran-boronic acid
-
-
7,8-dihydronaphthalene 2-O-sulfamate
-
-
7-hydroxy-4-methylcoumarin 6-O-sulfamate
-
-
AgNO3
-
5 mM, 65% inhibition
Ammonium molybdate
-
10 mM, 20% residual activity
calcium chloride
-
5 mM, 36% residual activity
cholesterol
-
1 mM, 57% inhibition
coumarin 7-O-sulfamate
-
-
cysteine
-
10 mM, 15% inhibition
dithiothreitol
-
5 mM, 45% residual activity
estra-1,3,5-(10)-triene-17-one-3-boronic acid
-
competitive
estrone 3-O-sulfamate
-
-
estrone-3-O-(N,N-dimethyl)sulfamate
-
-
estrone-3-O-(N-methyl)sulfamate
-
-
estrone-3-O-methylthiophosphonate
-
-
glutathione
-
reduced form, 5 mM, 23.5% residual activity
human pituitary luteinizing hormone
-
human pituitary LH, reduces activity to 85% of baseline at 5 ng/ml, dose-dependent
-
interleukin-1beta
-
marked inhibition of mRNA expression and STS activity
-
KH2PO4
-
5 mM, 25% inhibition
KW-2581
-
active site-directed irreversible steroidal inhibitor
methyl 2-(1-adamantyl)-4-oxo-4H-chromene-6-carboxylate
-
-
N,N-dihydroxy-6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromene-3-sulfinamide
-
-
N,N-dimethoxy-6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromene-3-sulfinamide
-
-
N-acetylated estrone 3-O-sulfamate
-
inhibits the enzyme irreversibly, albeit much less potently than estrone 3-O-sulfamate
Na2SO3
-
5 mM, 43% inhibition
Na2SO4
-
5 mM, 18% inhibition
p-Nitrophenyl sulfate
-
-
pregnenolone
-
1 mM, 10% inhibition
Steroids
-
overview, e.g. estrone, estradiol, C21 steroids, C19 steroids
STX213
-
phenol sulfamate pharmacophore, irreversible total inhibition from 10-1000 nM in Ishikawa cells, in vivo: upon administration of 1 mg/kg body mass/day reduced tumor growth over 28-day period in transplanted Ishikawa cells in MF-1 nude ovariectomized mice in the presence of estradiol sulfate (prerequisite for tumor cell development in ovariectomized mice), abolished liver STS activity, and reduced plasma estradiol levels
sulfamic acid 2-bromo-4-(2-((4-cyanophenyl)-[1,2,4]triazol-4-ylamino)ethyl)phenyl ester
-
ethylene linker, based on phenol sulfamate pharmacophore (STS inhibition) incorporated into YM511 (aromatase inhibitor) scaffold
sulfamic acid 2-bromo-4-(3-((4-cyanophenyl)-[1,2,4]triazol-4-ylamino)propyl)phenyl ester
-
propylene linker, based on phenol sulfamate pharmacophore (STS inhibition) incorporated into YM511 (aromatase inhibitor) scaffold
sulfamic acid 2-bromo-4-[[(4-cyanophenyl)[1,2,4]triazol-4-ylamino]methyl]phenyl ester
-
dual aromatase-sulfatase inhibitor, IC50 value for aromatase 0.82 nM
sulfamic acid 2-chloro-4-(2-((4-cyanophenyl)-[1,2,4]triazol-4-ylamino)ethyl)phenyl ester
-
ethylene linker, based on phenol sulfamate pharmacophore (STS inhibition) incorporated into YM511 (aromatase inhibitor) scaffold
sulfamic acid 2-chloro-4-(2-((4-cyanophenyl)-[1,2,4]triazol-4-ylamino)ethylsulfanyl)phenyl ester
-
thioether linker based on phenol sulfamate pharmacophore (STS inhibition) incorporated into YM511 (aromatase inhibitor) scaffold
sulfamic acid 2-chloro-4-(3-((4-cyanophenyl)-[1,2,4]triazol-4-ylamino)propyl)phenyl ester
-
propylene linker, based on phenol sulfamate pharmacophore (STS inhibition) incorporated into YM511 (aromatase inhibitor) scaffold
sulfamic acid 3-(((4-cyanophenyl)-[1,2,4]triazol-4-ylamino)methylsulfanyl)phenyl ester
-
thioether linker, based on phenol sulfamate pharmacophore (STS inhibition) incorporated into YM511 (aromatase inhibitor) scaffold
sulfamic acid 3-(2-((4-cyanophenyl)-[1,2,4]triazol-4-ylamino)-ethylsulfanyl)phenyl ester
-
thioether linker, based on phenol sulfamate pharmacophore (STS inhibition) incorporated into YM511 (aromatase inhibitor) scaffold
sulfamic acid 4-(((4-cyanophenyl)-(1,2,4)triazol-4-ylamino)methylsulfanyl)phenyl ester
-
thioether linker, , based on phenol sulfamate pharmacophore (STS inhibition) incorporated into YM511 (aromatase inhibitor) scaffold, best STS inhibitor of tested dual inhibitor compounds
sulfamic acid 4-((2-((4-cyanophenyl)-[1,2,4]triazol-4-ylamino)-ethyl)methylsulfamoyl)phenyl ester
-
N-methylated sulfonamide linker, based on phenol sulfamate pharmacophore (STS inhibition) incorporated into YM511 (aromatase inhibitor) scaffold
sulfamic acid 4-(10-((4-cyanophenyl)-[1,2,4]triazol-4-ylamino)decylsulfanyl)phenyl ester
-
thioether linker, based on phenol sulfamate pharmacophore (STS inhibition) incorporated into YM511 (aromatase inhibitor) scaffold
sulfamic acid 4-(2-((4-cyanophenyl)-[1,2,4]triazol-4-ylamino)-ethyl)phenyl ester
-
ethylene linker, based on phenol sulfamate pharmacophore (STS inhibition) incorporated into YM511 (aromatase inhibitor) scaffold
sulfamic acid 4-(2-((4-cyanophenyl)-[1,2,4]triazol-4-ylamino)-ethylsulfanylmethyl)phenyl ester
-
thioether linker, based on phenol sulfamate pharmacophore (STS inhibition) incorporated into YM511 (aromatase inhibitor) scaffold
sulfamic acid 4-(2-((4-cyanophenyl)-[1,2,4]triazol-4-ylamino)ethyl)-2-fluorophenyl ester
-
ethylene linker, based on phenol sulfamate pharmacophore (STS inhibition) incorporated into YM511 (aromatase inhibitor) scaffold
sulfamic acid 4-(3-((4-cyanophenyl)-[1,2,4]triazol-4-ylamino)-propyl)-2-fluorophenyl ester
-
propylene linker, based on phenol sulfamate pharmacophore (STS inhibition) incorporated into YM511 (aromatase inhibitor) scaffold
sulfamic acid 4-(3-((4-cyanophenyl)-[1,2,4]triazol-4-ylamino)propyl)phenyl ester
-
propylene linker, based on phenol sulfamate pharmacophore (STS inhibition) incorporated into YM511 (aromatase inhibitor) scaffold
sulfamic acid 4-(3-((4-cyanophenyl)-[1,2,4]triazol-4-ylamino)propylsulfanyl)phenyl ester
-
thioether linker, based on phenol sulfamate pharmacophore (STS inhibition) incorporated into YM511 (aromatase inhibitor) scaffold
sulfamic acid 4-(5-((4-cyanophenyl)-[1,2,4]triazol-4-ylamino)pentylsulfanyl)phenyl ester
-
thioether linker, based on phenol sulfamate pharmacophore (STS inhibition) incorporated into YM511 (aromatase inhibitor) scaffold
sulfamic acid 5-[[(4-cyanophenyl)[1,2,4]triazol-4-ylamino]-methyl]-2-fluorophenyl ester
-
dual aromatase-sulfatase inhibitor, IC50 value for aromatase 0.77 nM
TX-1299
-
non-steroid Theramex compound, strong inhibitor, IC50: 5.3 nM in JEG-3 cells, 0.76 nM in MCF-7 cells
-
TX-1492
-
non-steroid Theramex compound, strong inhibitor, IC50: 22.5 nM in JEG-3 cells, 0.07 nM in MCF-7 cells
-
TX-1506
-
non-steroid Theramex compound, strong inhibitor, IC50: 11.9 nM in JEG-3 cells, 0.06 nM in MCF-7 cells
-
vanadium oxide(V)
-
50 mM, 51% residual activity
Zinc acetate
-
1.25 mM, 53% residual activity
dehydroepiandrosterone
-
-
dehydroepiandrosterone
-
competitive to 16alpha-hydroxydehydroepiandrosterone
Estrone 3-sulfate
-
-
Estrone 3-sulfate
-
competitive inhibitor
estrone-3-O-sulfamate
-
-
estrone-3-O-sulfamate
-
active site-directed inhibitor
estrone-3-O-sulfamate
-
EMATE, most potent, irreversible
estrone-3-O-sulfamate
-
also in vivo
estrone-3-O-sulfamate
-
potent inhibitor, dose-dependent, maximum inhibition between 100 and 1000 nM
estrone-3-O-sulfamate
-
specific inhibitor, concentration-dependent, complete inhibition at 0.1 mM, 100 nM and 10 nM, 89% inhibition at 1 nM
estrone-3-sulfamate
-
best inhibitor, IC50: 3.2 nM in JEG-3 cells, 0.08 nM in MCF-7 cells
estrone-3-sulfamate
-
potent estrone sulfatase inhibitor that causes irreversible inactivation of the enzyme
irosustat
-
i.e. BN83495
irosustat
-
i.e. STX64, BN83495, structure-activity relationship study. The inhibitor is used in clinical trials for patients with advanced hormone-dependent cancer
STX64
-
strong STS inhibitor with phenol sulfamate pharmacophore, basis for STS inhibition in dual inhibitors in scaffold of aromatase inhibitor YM511
STX64
-
synonym BN83495, phenol sulfamate pharmacophore, irreversible STS inhibition from 10-1000 nM in Ishikawa cells, irreversible inhibition in OVCAR-3 ovarian cancer cells and JEG-3 choriocarcionoma cells at 10µM, irreversible inhibition from 10-1000 nM in LNCaP prostate cancer cells, in vivo: upon administration of 1 mg/kg body mass/day reduced tumor growth over 28-day period in transplanted Ishikawa cells in MF-1 nude ovariectomized mice in the presence of estradiol sulfate (prerequisite for tumor cell development in ovariectomized mice), abolished liver STS activity, and reduced plasma estradiol levels
STX64
-
synonyms BN83495 or 667Coumate, 1 mg/kg/day given orally, treatment starting at Ishikawa cell tumor size of about 100 cubic mm (intact mice): no significant tumor growth reduction after 35 days of inhibitor treatment. Estradiol sulfate stimulated tumor growth of Ishikawa cells in ovariectomized mice, results after day 28 of inhibitor treatment: 1 mg/kg/day given orally reduces tumor growth by 48%, complete Ishikawa cell tumor STS inhibition, 1 mg/kg given orally once weekly: no tumor growth inhibition, no tumor STS inhibition, 10 mg/kg/day given orally: tumor growth inhibition by 59%, complete tumor STS inhibition
STX64
-
i.e. 667 Coumate or BN83495
additional information
design of sulfated steroid inhibitors. The presence of a NO2 or Br at the 2-position of the A-ring results in a decrease in potency compared to their A-ring-unsubstituted counterparts. The presence of a nitro group or fluorine atom at the 4-position of the A-ring results in an increase in potency
-
additional information
-
not inhibited by danazol or letrozole
-
additional information
-
not inhibited by estrone, dehydroepiandrosterone, alkaline phosphatase treatment and phosphohydrolase inhibitors
-
additional information
-
not inhibitory: phosphate, sulfate, sulfide
-
additional information
-
not inhibited by letrozole, 5'-((1H-1,2,4-triazol-1-yl)methyl)-2'-cyanobiphenyl-4-yl dimethylsulfamate, 5'-((1H-1,2,4-triazol-1-yl)methyl)-3-chloro-2'-cyanobiphenyl-4-yl dimethylsulfamate, 5'-((1H-1,2,4-triazol-1-yl)methyl)-4-chloro-2'-cyanobiphenyl-3-yl sulfamate, 3'-((1H-1,2,4-triazol-1-yl)methyl)-4'-cyanobiphenyl-3-yl sulfamate, 3'-((1H-1,2,4-triazol-1-yl)methyl)-5'-cyanobiphenyl-4-yl sulfamate, 2'-((1H-1,2,4-triazol-1-yl)methyl)-3-chloro-5'-cyanobiphenyl-4-yl sulfamate, and 3'-((1H-1,2,4-triazol-1-yl)methyl)-5'-(2-cyanopropan-2-yl)biphenyl-4-yl sulfamate
-
additional information
-
design and synthesis of steroidal and nonsteroidal enzyme inhibitors as sulfamate derivatives and nonsulfamate derivatives, overview
-
additional information
-
evaluation of quinolin-2(1H)-one and quinoline derivatives of irosustat as enzyme inhibitors. N-(piperidino), N,N-(dibenzyl)sulfamate, and N,N-dimethyl derivatives of estrone 3-O-sulfamate are weak reversible or inactive inhibitors of the enzyme in placental microsomes. No inhibition by the N-benzoyl estrone 3-O-sulfamate variant 3-(benzyloxy)-8,9,10,11-tetrahydro-5H-cyclohepta[c]quinolin-6(7H)-one. Molecular modelling
-
additional information
-
inhibitor development of the enzyme in cancer treatment, clinical studies, overview
-
additional information
-
sulfamoyloxy-substituted 2-phenylindoles are developed as antiestrogen-based inhibitors of estrone sulfatase. A series of compounds that can inhibit both aromatase and sulfatase is developed based on the structure of estrone 3-sulfamate, a typical estrone sulfatase inhibitor
-
additional information
-
synthesis and in vitro evaluation of the inhibitory potency of an extended series of 17alpha derivatives of estradiol, structure-activity relationship study, overview
-
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3(or 17)beta-hydroxysteroid dehydrogenase deficiency
Isolated dehydroepiandrosterone sulphate hypersecretion: a case report.
Abortion, Spontaneous
Elevated levels of dehydroepiandrosterone as a potential mechanism of dendritic cell impairment during pregnancy.
Abortion, Spontaneous
Unconjugated estriol as an indication for prenatal diagnosis of steroid sulfatase deficiency by in situ hybridization.
Abscess
Serum testosterone, DHEAS, and prolactin levels in patients with a Bartholin's abscess.
Acanthosis Nigricans
Correlation of Cutaneous Manifestations with Body Mass Index, Blood Glucose, and Hormonal Levels in Patients with Polycystic Ovarian Disease.
Acne Vulgaris
A randomized controlled trial of second- versus third-generation oral contraceptives in the treatment of acne vulgaris.
Acne Vulgaris
Androgenicity and fertility treatment in women with unexplained infertility.
Acne Vulgaris
CAG repeat polymorphism in androgen receptor gene is not directly associated with polycystic ovary syndrome but influences serum testosterone levels.
Acne Vulgaris
Clinical, ultrasound and hormonal markers of androgenicity in acne vulgaris.
Acne Vulgaris
Comparison of adrenocortical steroidogenesis in women with post-adolescent severe acne and polycystic ovary syndrome.
Acne Vulgaris
Correlation between serum levels of insulin-like growth factor 1, dehydroepiandrosterone sulfate, and dihydrotestosterone and acne lesion counts in adult women.
Acne Vulgaris
Cutaneous androgen metabolism: basic research and clinical perspectives.
Acne Vulgaris
Hyperandrogenemia in patients presenting with acne.
Acne Vulgaris
Metabolic alterations of DHEA and cholesterol sulphates in the hair of patients with acne measured by liquid chromatography-mass spectrometry.
Acne Vulgaris
Metformin therapy decreases hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome.
Acne Vulgaris
Phenotypic spectrum of polycystic ovary syndrome: clinical and biochemical characterization of the three major clinical subgroups.
Acne Vulgaris
Predictors of severity of acne vulgaris in young adolescent girls: results of a five-year longitudinal study.
Acne Vulgaris
Steroid sulfatase activity in epidermis of acne-prone and non-acne-prone skin of patients with acne vulgaris.
Acne Vulgaris
The association of serum androsterone glucuronide with inflammatory lesions in women with adult acne.
Acne Vulgaris
[Androgenic evaluation of women with late-onset or persistent acne]
Acne Vulgaris
[Effect on skin and hormonal hyperandrogenic manifestations of an oral estroprogestin association containing ethynilestradiol 30 mg and drospirenone 3 mg]
Acquired Immunodeficiency Syndrome
Dehydroepiandrosterone sulfate (DHEAS) and testosterone: relation to HIV illness stage and progression over one year.
Addison Disease
Origin and significance of plasma androsterone glucuronide levels: a parameter of adrenal androgen secretion and hepatic 5 alpha-reductase activity.
Addison Disease
The importance of adrenal hypoandrogenism in infertile women with low functional ovarian reserve: a case study of associated adrenal insufficiency.
Adenocarcinoma
Dehydroepiandrosterone modulates oxidative DNA damage in pancreatic cancer: A case-control study.
Adenocarcinoma
In situ steroid sulfatase activity in human epithelial carcinoma cells of vaginal, ovarian, and endometrial origin.
Adenocarcinoma
Inhibition of protein farnesyltransferase: a possible mechanism of tumor prevention by dehydroepiandrosterone sulfate.
Adenocarcinoma
Lifelong treatment with oral DHEA sulfate does not preserve immune function, prevent disease, or improve survival in genetically heterogeneous mice.
Adenocarcinoma
Steroid sulfatase expression in ovarian clear cell adenocarcinoma: immunohistochemical study.
Adenocarcinoma, Clear Cell
Steroid sulfatase expression in ovarian clear cell adenocarcinoma: immunohistochemical study.
Adenoma
A case of Cushing's syndrome due to bilateral cortisol-secreting adenomas with unilateral DHEAS oversecretion.
Adenoma
Adrenal and sex steroid hormone production by a virilizing adrenal adenoma and its diagnosis with computerized tomography.
Adenoma
Adrenal incidentaloma: an overview of hormonal data from the National Italian Study Group.
Adenoma
Asymptomatic adrenal tumours: criteria for endoscopic removal.
Adenoma
DHEAS and Differential Blood Counts as Indirect Signs of Glucocorticoid Excess in Adrenal Non-Producing Adenomas.
Adenoma
Is there an association between non-functioning adrenal adenoma and endothelial dysfunction?
Adenoma
Laparoscopic adrenalectomy. The importance of a flank approach in the lateral decubitus position.
Adenoma
Plasma dehydroepiandrosterone sulfate levels in patients with hyperfunctioning and non-hyperfunctioning adrenal tumors before and after adrenal surgery.
Adenoma
Steroid sulfation in adrenal tumors.
Adenoma
The value of dehydroepiandrosterone sulfate measurement in the differentiation between benign and malignant adrenal masses.
Adenoma
[Incidentaloma of the adrenal glands: analysis of 9 surgical cases]
Adenomyosis
Immunohistologic localization of estrone sulfatase in uterine endometrium and adenomyosis.
Adrenal Gland Neoplasms
Isolated DHEAS production by an adrenal neoplasm: Clinical, biochemical and pathologic characteristics.
Adrenal Gland Neoplasms
The value of dehydroepiandrosterone sulfate measurement in the differentiation between benign and malignant adrenal masses.
Adrenal Hyperplasia, Congenital
Adrenarche does not occur in treated patients with congenital adrenal hyperplasia resulting from 21-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Development of a method for the measurement of dehydroepiandrosterone sulphate by liquid chromatography-tandem mass spectrometry.
Adrenal Hyperplasia, Congenital
Disproportionate suppression of dehydroepiandrosterone sulfate (DHEAS) in treated patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Hydrocortisone treatment in girls with congenital adrenal hyperplasia inhibits serum dehydroepiandrosterone sulfate and affects the GH-IGF-I system.
Adrenal Hyperplasia, Congenital
Importance of Dehydroepiandrosterone Sulfate Assessment with Special Attention for Adrenal Tumours and Arterial Hypertension.
Adrenal Hyperplasia, Congenital
Isolated dehydroepiandrosterone sulphate hypersecretion: a case report.
Adrenal Hyperplasia, Congenital
Premature Adrenarche and its Association with Cardiovascular Risk in Females.
Adrenal Insufficiency
Adrenal androgen and glucocorticoid dissociation in premenopausal rheumatoid arthritis: a significant correlate or precursor to onset?
Adrenal Insufficiency
Adrenal steroids in adrenomyeloneuropathy Dehydroepiandrosterone sulfate, androstenedione and 17alpha-hydroxyprogesterone.
Adrenal Insufficiency
Androgen deficiency in women with hypopituitarism.
Adrenal Insufficiency
Central adrenal insufficiency could not be confirmed by measurement of basal serum DHEAS levels in pubertal children.
Adrenal Insufficiency
Decreased levels of dehydroepiandrosterone sulphate in severe critical illness: a sign of exhausted adrenal reserve?
Adrenal Insufficiency
Dehydroepiandrosterone: a potential therapeutic agent in the treatment and rehabilitation of the traumatically injured patient.
Adrenal Insufficiency
Dehydroepiandrosterone: a springboard hormone for female sexuality.
Adrenal Insufficiency
DHEAS deficiency during consumption of sustained-action prescribed opioids: evidence for opioid-induced inhibition of adrenal androgen production.
Adrenal Insufficiency
Effects of dehydroepiandrosterone sulphate (DHEAS) replacement on insulin action and quality of life in hypopituitary females: a double blind placebo controlled study.
Adrenal Insufficiency
Importance of Dehydroepiandrosterone Sulfate Assessment with Special Attention for Adrenal Tumours and Arterial Hypertension.
Adrenal Insufficiency
Is DHEA replacement beneficial in chronic adrenal failure?
Adrenal Insufficiency
New PCOS-like phenotype in older infertile women of likely autoimmune adrenal etiology with high AMH but low androgens.
Adrenocortical Adenoma
Benign cortisol-secreting adrenocortical adenomas produce small amounts of androgens.
Adrenocortical Adenoma
Plasma dehydroepiandrosterone sulfate levels in patients with hyperfunctioning and non-hyperfunctioning adrenal tumors before and after adrenal surgery.
Adrenocortical Adenoma
Reduced serum levels of dehydroepiandrosterone sulphate in adrenal incidentalomas: a marker of adrenocortical tumour.
Adrenocortical Carcinoma
American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach.
Adrenocortical Carcinoma
Label-free impedimetric immunosensor based on arginine-functionalized gold nanoparticles for detection of DHEAS, a biomarker of pediatric adrenocortical carcinoma.
Adrenocortical Carcinoma
Plasma dehydroepiandrosterone sulfate levels in patients with hyperfunctioning and non-hyperfunctioning adrenal tumors before and after adrenal surgery.
Adrenoleukodystrophy
Adrenal steroids in adrenomyeloneuropathy Dehydroepiandrosterone sulfate, androstenedione and 17alpha-hydroxyprogesterone.
Albinism, Ocular
An Xp22 microdeletion associated with ocular albinism and ichthyosis: approximation of breakpoints and estimation of deletion size by using cloned DNA probes and flow cytometry.
Albinism, Ocular
Deletion analysis maps ocular albinism proximal to the steroid sulphatase locus.
Albinism, Ocular
Detection of KAL-1 gene deletion with fluorescence in situ hybridization.
Albinism, Ocular
Linkage analysis in X-linked ocular albinism.
Alopecia
Alterations in androgen conjugate levels in women and men with alopecia.
Alopecia
Importance of Dehydroepiandrosterone Sulfate Assessment with Special Attention for Adrenal Tumours and Arterial Hypertension.
Alopecia
Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist?
Alopecia
Steroid sulfatase in the human hair follicle concentrates in the dermal papilla.
alpha-Thalassemia
Frequent deletions of the human X chromosome distal short arm result from recombination between low copy repetitive elements.
Alzheimer Disease
Age and sex differences of dehydroepiandrosterone sulfate (DHEAS) and cortisol (CRT) plasma levels in normal controls and Alzheimer's disease (AD).
Alzheimer Disease
Age-related changes of the adrenal secretory pattern: possible role in pathological brain aging.
Alzheimer Disease
Dehydroepiandrosterone (DHEA) and its Sulphate (DHEAS) in Alzheimer's Disease.
Alzheimer Disease
Dehydroepiandrosterone sulfate decreases the interleukin-2-mediated overactivity of the natural killer cell compartment in senile dementia of the Alzheimer type.
Alzheimer Disease
Dehydroepiandrosterone sulphate (DHEAS) in the oldest old, aged 85 and over.
Alzheimer Disease
Rapid column-switching liquid chromatography/mass spectrometric assay for DHEA-sulfate in the plasma of patients with Alzheimer's disease.
Alzheimer Disease
Serum dehydroepiandrosterone sulfate in Alzheimer's disease and in multi-infarct dementia.
Amnesia
Chronic steroid sulfatase inhibition by (p-O-sulfamoyl)-N-tetradecanoyl tyramine increases dehydroepiandrosterone sulfate in whole brain.
Amnesia
Enhanced plasma DHEAS, brain acetylcholine and memory mediated by steroid sulfatase inhibition.
Amnesia
Memory enhancement mediated by the steroid sulfatase inhibitor (p-O-sulfamoyl)-N-tetradecanoyl tyramine.
Amnesia
Possible role of nitric oxide in the nootropic and antiamnesic effects of neurosteroids on aging- and dizocilpine-induced learning impairment.
Amnesia
Reversal of scopolamine induced amnesia in rats by the steroid sulfatase inhibitor estrone-3-O-sulfamate.
Amnesia
The effect of steroid sulfatase inhibition on learning and spatial memory.
Anemia
Higher serum concentrations of DHEAS predict improved nutritional status in helminth-infected children, adolescents, and young adults in Leyte, the Philippines.
Anencephaly
Unconjugated estriol as an indication for prenatal diagnosis of steroid sulfatase deficiency by in situ hybridization.
Angina Pectoris
von Willebrand factor, tissue plasminogen activator, and dehydroepiandrosterone sulphate predict cardiovascular death in a 10 year follow up of survivors of acute myocardial infarction.
Angiomyolipoma
Laparoscopic adrenalectomy. The importance of a flank approach in the lateral decubitus position.
Anosmia
A new syndrome of anosmia, ichthyosis, hypogonadism, and various neurological manifestations with deficiency of steroid sulfatase and arylsulfatase C.
Anosmia
Hypogonadotrophic hypogonadism with hyposmia, X-linked ichthyosis, and renal malformation syndrome.
Anosmia
More on X-linked ichthyosis, steroid sulfatase deficiency, and hypogonadism and anosmia.
Anosmia
X-linked ichthyosis due to steroid sulfatase deficiency associated with hypogonadism and anosmia.
Anovulation
Differential response to adrenocorticotropin hormone stimulation in polycystic ovarian disease with high and low dehydroepiandrosterone sulfate levels.
Anovulation
Inactivating PAPSS2 mutations in a patient with premature pubarche.
Anovulation
The ratio of androstenedione:11 beta-hydroxyandrostenedione is an important marker of adrenal androgen excess in women.
Arteriosclerosis
Association of endogenous DHEA/DHEAS with coronary heart disease: A systematic review and meta-analysis.
Arteritis
Low serum levels of DHEAS in untreated polymyalgia rheumatica/giant cell arteritis.
Arthralgia
Dehydroepiandrostenedione sulphate (DHEAS) levels predict high risk of rheumatoid arthritis (RA) in subclinical hypothyroidism.
Arthritis
Hyposecretion of the adrenal androgen dehydroepiandrosterone sulfate and its relation to clinical variables in inflammatory arthritis.
Arthritis
Relation between placental growth factor-1 (PlGF-1) and vascularization, DHEAS to DHEA conversion, or aromatase expression in patients with arthritis.
Arthritis, Rheumatoid
Adrenal androgens and the immune system.
Arthritis, Rheumatoid
Basal levels of DHEAS as a marker for disease activity in premenopausal women with recent onset rheumatoid arthritis.
Arthritis, Rheumatoid
Blood dehydroepiandrosterone sulphate (DHEAS) levels in polymyalgia rheumatica/giant cell arteritis and primary fibromyalgia.
Arthritis, Rheumatoid
Contribution of Genetic Factors to Lower DHEAS in Patients with Rheumatoid Arthritis.
Arthritis, Rheumatoid
Dehydroepiandrostenedione sulphate (DHEAS) levels predict high risk of rheumatoid arthritis (RA) in subclinical hypothyroidism.
Arthritis, Rheumatoid
Hypothalamic-pituitary-adrenal axis impairment in the pathogenesis of rheumatoid arthritis and polymyalgia rheumatica.
Arthritis, Rheumatoid
Increased DHEAS levels in patients with rheumatoid arthritis after treatment with tumor necrosis factor antagonists: evidence for improved adrenal function.
Arthritis, Rheumatoid
Relationship between blood and joint tissue DHEAS levels in rheumatoid arthritis and osteoarthritis.
Arthritis, Rheumatoid
Weak androgen levels, glucocorticoid therapy, and bone mineral density in postmenopausal women with rheumatoid arthritis.
arylsulfatase (type i) deficiency
Arylsulfatases A and B in EBV-transformed lymphoid cell lines: studies on their molecular forms in cells from patients with inborn sulfatase deficiencies. Comparative diagnostic value of enzymatic assays.
arylsulfatase (type i) deficiency
Ichthyosis: the skin manifestation of multiple sulfatase deficiency.
arylsulfatase (type i) deficiency
Multiple sulfatase deficiency: catalytically inactive sulfatases are expressed from retrovirally introduced sulfatase cDNAs.
arylsulfatase (type i) deficiency
Placental sulfatase deficiency: maternal and fetal expression of steroid sulfatase deficiency and X-linked ichthyosis.
arylsulfatase (type i) deficiency
Rapid degradation of steroid sulfatase in multiple sulfatase deficiency.
arylsulfatase (type i) deficiency
Steroid sulfatase deficiency.
arylsulfatase (type i) deficiency
Steroid sulfatase sulfatase deficiency and androgen activation before and after puberty.
arylsulfatase (type i) deficiency
Synthesis and stability of steroid sulfatase in fibroblasts from multiple sulfatase deficiency.
Asthenozoospermia
[Andrologic studies in patients with X-chromosome recessive ichthyosis]
Asthma
Allergic disease as an association of steroid sulphatase deficiency.
Asthma
Effects of hormone replacement therapy on endocrine and spirometric parameters in asthmatic postmenopausal women.
Asthma
Independent association between insulin-like growth factor-I and dehydroepiandrosterone sulphate in women in middle adulthood.
Asthma
Nebulized dehydroepiandrosterone-3-sulfate improves asthma control in the moderate-to-severe asthma results of a 6-week, randomized, double-blind, placebo-controlled study.
Atherosclerosis
Adrenal Hyperandrogenism and Polycystic Ovary Syndrome.
Atherosclerosis
Berberine cooperates with adrenal androgen dehydroepiandrosterone sulfate to attenuate PDGF-induced proliferation of vascular smooth muscle cell A7r5 through Skp2 signaling pathway.
Atherosclerosis
Changes in plasma DHEAS circadian rhythm in elderly men.
Atherosclerosis
Dehydroepiandrosterone sulfate, incidence of myocardial infarction, and extent of atherosclerosis in men.
Atherosclerosis
Distribution of dehydroepiandrosterone sulfate and relationships between its level and serum lipid levels in a rural Japanese population.
Atherosclerosis
Effects of dehydroepiandrosterone sulfate on cellular calcium responsiveness and vascular contractility.
Atherosclerosis
Inhibition of vascular inflammation by dehydroepiandrosterone sulfate in human aortic endothelial cells: Roles of PPARalpha and NF-kappaB.
Atherosclerosis
Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study.
Atherosclerosis
No association between dehydroepiandrosterone sulfate and development of atherosclerosis in a prospective population study (Bruneck Study).
Atherosclerosis
Relationship between dehydroepiandrosterone sulfate and serum lipid levels in Japanese men.
Atherosclerosis
Serum Amyloid A, Paraoxonase-1 Activity, and Apolipoprotein Concentrations as Biomarkers of Subclinical Atherosclerosis Risk in Adrenal Incidentaloma Patients.
Atherosclerosis
Serum DHEAS levels correlate with platelet cGMP in normal women.
Atherosclerosis
[Replacement therapy in adrenopause. Dehydroepiandrosterone and aging]
Atrial Fibrillation
Dehydroepiandrosterone sulfate levels and risk of atrial fibrillation: The Rotterdam Study.
Atrial Fibrillation
Dehydroepiandrosterone-sulfate serum levels and common age-related diseases: results from a cross-sectional Italian study of a general elderly population.
Autoimmune Diseases
Administration of dehydroepiandrosterone sulfate retards onset but not progression of autoimmune disease in NZB/W mice.
Autoimmune Diseases
Blood dehydroepiandrosterone sulphate (DHEAS) levels in pemphigoid/pemphigus and psoriasis.
Autoimmune Diseases
Dehydroepiandrosterone sulphate serum levels in systemic sclerosis.
Autoimmune Diseases
[The role of adrenal and gonadal hormones in the pathogenesis of autoimmune polyarthritis]
Azoospermia
[Genetic analysis of a rare case with Kallman syndrome and steroid sulfatase deficiency].
Beckwith-Wiedemann Syndrome
Functional Adrenocortical Adenoma in a Child with Beckwith-Wiedemann Syndrome.
Bone Diseases
Serum dehydroepiandrosterone sulfate, testosterone, and biochemical markers of bone turnover in elderly Thai men.
Bone Diseases, Metabolic
Dehydroepiandrosterone and Bone.
Bone Diseases, Metabolic
Dehydroepiandrosterone sulphate in the diagnosis of osteoporosis.
Bone Diseases, Metabolic
The evaluation of hormonal and psychological parameters that affect bone mineral density in postmenopausal women.
Bone Diseases, Metabolic
[Reduced serum dehydroepiandrosterone levels in postmenopausal osteoporosis]
Bone Resorption
Dehydroepiandrosterone: a springboard hormone for female sexuality.
Bone Resorption
Physiologic regulators of bone turnover in young women with anorexia nervosa.
Bone Resorption
Relationship between bone resorption and adrenal sex steroids and their derivatives in oophorectomized women.
Bone Resorption
Serum dehydroepiandrosterone sulfate, testosterone, and biochemical markers of bone turnover in elderly Thai men.
Brain Concussion
DHEAS repeated treatment improves cognitive and behavioral deficits after mild traumatic brain injury.
Brain Diseases
Dehydroepiandrosterone sulphate: action and mechanism in the brain.
Brain Injuries
Dehydroepiandrosterone sulfate is neuroprotective when administered either before or after injury in a focal cortical cold lesion model.
Brain Injuries, Traumatic
Astrocyte Neuroprotection and Dehydroepiandrosterone.
Brain Neoplasms
Steroid sulfatase and sulfuryl transferase activities in human brain tumors.
Breast Cyst
A simple, accurate, and sensitive assay method of dehydroepiandrosterone sulfate: application for quantitative determination in human breast cyst and duct fluids.
Breast Cyst
Accumulation of 4- and 5-ene steroid sulfates in human breast cyst fluids.
Breast Cyst
Cytokines in human breast cyst fluid.
Breast Neoplasms
2-phenylindole sulfamates: inhibitors of steroid sulfatase with antiproliferative activity in MCF-7 breast cancer cells.
Breast Neoplasms
A new hormonal therapy for estrogen receptor-negative breast cancer.
Breast Neoplasms
A novel dual-target steroid sulfatase inhibitor and antiestrogen: SR 16157, a promising agent for the therapy of breast cancer.
Breast Neoplasms
A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models.
Breast Neoplasms
A phase I dose escalation study to determine the optimal biological dose of irosustat, an oral steroid sulfatase inhibitor, in postmenopausal women with estrogen receptor-positive breast cancer.
Breast Neoplasms
A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents.
Breast Neoplasms
Androgens and musculoskeletal symptoms among breast cancer patients on aromatase inhibitor therapy.
Breast Neoplasms
Anti-breast cancer potential of natural and synthetic coumarin derivatives.
Breast Neoplasms
Anti-tumor effect of Shu-Gan-Liang-Xue decoction in breast cancer is related to the inhibition of aromatase and steroid sulfatase expression.
Breast Neoplasms
Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography.
Breast Neoplasms
Aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole and vorozole templates.
Breast Neoplasms
Association between alcohol intake and serum sex hormones and peptides differs by tamoxifen use in breast cancer survivors.
Breast Neoplasms
Bone morphogenetic protein 6 (BMP6) and BMP7 inhibit estrogen-induced proliferation of breast cancer cells by suppressing p38 mitogen-activated protein kinase activation.
Breast Neoplasms
Breast cancer: from estrogen to androgen receptor.
Breast Neoplasms
C-3- and C-4-Substituted Bicyclic Coumarin Sulfamates as Potent Steroid Sulfatase Inhibitors.
Breast Neoplasms
Chromatographic analysis and decomposition product characterization of compound SR16157 (NSC 732011).
Breast Neoplasms
Confocal fluorescence detection expanded to UV excitation: the first continuous fluorimetric assay of human steroid sulfatase in nanoliter volume.
Breast Neoplasms
Constitutive expression of the steroid sulfatase gene supports the growth of MCF-7 human breast cancer cells in vitro and in vivo.
Breast Neoplasms
Constitutive Expression of the Steroid Sulfatase Gene Supports the Growth of MCF-7 Human Breast Cancer Cells in Vitroand in Vivo.
Breast Neoplasms
Conversion of dehydroepiandrosterone sulfate at physiological plasma concentration into estrogens in MCF-7 cells.
Breast Neoplasms
Correction to: IRIS study: a phase II study of the steroid sulfatase inhibitor Irosustat when added to an aromatase inhibitor in ER-positive breast cancer patients.
Breast Neoplasms
Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, a novel anti-cancer agent.
Breast Neoplasms
Daidzein sulfoconjugates are potent inhibitors of sterol sulfatase (EC 3.1.6.2).
Breast Neoplasms
Dehydroepiandrosterone concentration in breast cancer tissue is related to its plasma gradient across the mammary gland.
Breast Neoplasms
Dehydroepiandrosterone sulfate and breast cancer risk.
Breast Neoplasms
Dehydroepiandrosterone sulfate estrogenic action at its physiological plasma concentration in human breast cancer cell lines.
Breast Neoplasms
Design and synthesis of carbon-11-labeled dual aromatase-steroid sulfatase inhibitors as new potential PET agents for imaging of aromatase and steroid sulfatase expression in breast cancer.
Breast Neoplasms
Design and synthesis of silicon-containing steroid sulfatase inhibitors possessing pro-estrogen antagonistic character.
Breast Neoplasms
Detection of breast cancer-associated estrone sulfatase in breast cancer biopsies and cell lines using polymerase chain reaction.
Breast Neoplasms
Development of (p-O-sulfamoyl)-N-alkanoyl-phenylalkyl amines as non-steroidal estrone sulfatase inhibitors.
Breast Neoplasms
Development of a sensitive high-performance liquid chromatography method for the detection of 667 COUMATE in vivo.
Breast Neoplasms
Development of novel steroid sulfatase inhibitors. I. Synthesis and biological evaluation of biphenyl-4-O-sulfamates.
Breast Neoplasms
Development of novel steroid sulfatase inhibitors; II. TZS-8478 potently inhibits the growth of breast tumors in postmenopausal breast cancer model rats.
Breast Neoplasms
Development of potent non-estrogenic estrone sulfatase inhibitors.
Breast Neoplasms
DHEAS prevents pro-metastatic and proliferative effects of 17ß-estradiol on MCF-7 breast cancer cells.
Breast Neoplasms
Differential effects of progestins on breast tissue enzymes.
Breast Neoplasms
Differential increase of steroid sulfatase activity in XX and XY trophoblast cells from human term placenta with syncytia formation in vitro.
Breast Neoplasms
Direct evidence for ArO-S bond cleavage upon inactivation of Pseudomonas aeruginosa arylsulfatase by aryl sulfamates.
Breast Neoplasms
Discovery of a sulfamate-based steroid sulfatase inhibitor with intrinsic selective estrogen receptor modulator properties.
Breast Neoplasms
Distribution of 16alpha-[18F]fluoro-estradiol-3,17beta-disulfamate in rats, tumour-bearing mice and piglets.
Breast Neoplasms
Dual aromatase-sulfatase inhibitors based on the anastrozole template: synthesis, in vitro SAR, molecular modelling and in vivo activity.
Breast Neoplasms
Effect of nomegestrol acetate on estrone-sulfatase and 17beta-hydroxysteroid dehydrogenase activities in human breast cancer cells.
Breast Neoplasms
Effect of tamoxifen or anastrozole on steroid sulfatase activity and serum androgen concentrations in postmenopausal women with breast cancer.
Breast Neoplasms
Effect of tibolone (Org OD14) and its metabolites on aromatase and estrone sulfatase activity in human breast adipose stromal cells and in MCF-7 and T47D breast cancer cells.
Breast Neoplasms
Efficacy of three potent steroid sulfatase inhibitors: pre-clinical investigations for their use in the treatment of hormone-dependent breast cancer.
Breast Neoplasms
Estradiol inhibits the estrone sulfatase activity in normal and cancerous human breast tissues.
Breast Neoplasms
Estrogen sulfotransferase and steroid sulfatase in human breast carcinoma.
Breast Neoplasms
Estrogenicity, antiestrogenicity and estrone sulfatase inhibition of estrone-3-amine and estrone-3-thiol.
Breast Neoplasms
Estrone 3-sulfate mimics, inhibitors of estrone sulfatase activity: homology model construction and docking studies.
Breast Neoplasms
Estrone and dehydroepiandrosterone sulfatase activities and plasma estrone sulfate levels in human breast carcinoma.
Breast Neoplasms
Estrone sulfatase activity and effect of antiestrogens on transformation of estrone sulfate in hormone-dependent vs. independent human breast cancer cell lines.
Breast Neoplasms
Estrone sulfatase versus estrone sulfotransferase in human breast cancer: potential clinical applications.
Breast Neoplasms
Estrone sulfate analogs as estrone sulfatase inhibitors.
Breast Neoplasms
Estrone sulfate and sulfatase activity in human breast cancer and endometrial cancer.
Breast Neoplasms
Estrone sulfate promotes human breast cancer cell replication and nuclear uptake of estradiol in MCF-7 cell cultures.
Breast Neoplasms
Estrone sulfate stimulates growth of nitrosomethylurea-induced breast carcinoma in vivo in the rat.
Breast Neoplasms
Expression of 17beta-hydroxysteroid dehydrogenases and other estrogen-metabolizing enzymes in different cancer cell lines.
Breast Neoplasms
Expression of Estrogen Sulfotransferase 1E1 and Steroid Sulfatase in Breast Cancer: A Immunohistochemical Study.
Breast Neoplasms
Expression of estrogenicity genes in a lineage cell culture model of human breast cancer progression.
Breast Neoplasms
Expression of sulfotransferases and sulfatases in human breast cancer: Impact on resveratrol metabolism.
Breast Neoplasms
High expression of steroid sulfatase mRNA predicts poor prognosis in patients with estrogen receptor-positive breast cancer.
Breast Neoplasms
Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template.
Breast Neoplasms
Hybrid dual aromatase-steroid sulfatase inhibitors with exquisite picomolar inhibitory activity.
Breast Neoplasms
Immunohistochemical analysis of estrone sulfatase and aromatase in human breast cancer tissues.
Breast Neoplasms
Immunohistochemical analysis of steroid sulfatase in human tissues.
Breast Neoplasms
Impairment of the Gn?11-controlled expression of claudin-1 and MMP-9 and collective migration of human breast cancer MCF-7 cells by DHEAS.
Breast Neoplasms
In breast cancer subtypes steroid sulfatase (STS) is associated with less aggressive tumour characteristics.
Breast Neoplasms
In situ estrogen production via the estrone sulfatase pathway in breast tumors: relative importance versus the aromatase pathway.
Breast Neoplasms
In situ production of estrogens in human breast carcinoma.
Breast Neoplasms
In situ production of sex steroids in human breast carcinoma.
Breast Neoplasms
In vitro and in vivo models for the evaluation of new inhibitors of human steroid sulfatase, devoid of residual estrogenic activity.
Breast Neoplasms
In vitro effect of synthetic progestogens on estrone sulfatase activity in human breast carcinoma.
Breast Neoplasms
In vivo activity of 4-methylcoumarin-7-O-sulfamate, a nonsteroidal, nonestrogenic steroid sulfatase inhibitor.
Breast Neoplasms
In vivo efficacy of STX213, a second-generation steroid sulfatase inhibitor, for hormone-dependent breast cancer therapy.
Breast Neoplasms
In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE.
Breast Neoplasms
Inactivation of steroid sulfatase by an active site-directed inhibitor, estrone-3-O-sulfamate.
Breast Neoplasms
Inclusion of Endogenous Plasma Dehydroepiandrosterone Sulfate and Mammographic Density in Risk Prediction Models for Breast Cancer.
Breast Neoplasms
Inhibition of estrone sulfatase activity by estrone-3-methylthiophosphonate: a potential therapeutic agent in breast cancer.
Breast Neoplasms
Inhibition of estrone sulfatase and 17 beta-hydroxysteroid dehydrogenase by antiestrogens.
Breast Neoplasms
Inhibition of estrone sulfatase and proliferation of human breast cancer cells by nonsteroidal (p-O-sulfamoyl)-N-alkanoyl tyramines.
Breast Neoplasms
Inhibition of estrone sulfatase enzyme in human placenta and human breast carcinoma.
Breast Neoplasms
Inhibition of estrone sulfatase in human liver microsomes by quercetin and other flavonoids.
Breast Neoplasms
Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate.
Breast Neoplasms
Inhibition of oestrone sulphatase activity by tibolone and its metabolites.
Breast Neoplasms
Inhibition of placental estrone sulfatase activity and MCF-7 breast cancer cell proliferation by estrone-3-amino derivatives.
Breast Neoplasms
Inhibition of steroid sulfatase activity and cell proliferation in ZR-75-1 and BT-474 human breast cancer cells by KW-2581 in vitro and in vivo.
Breast Neoplasms
Inhibition of steroid sulfatase with 4-substituted estrone and estradiol derivatives.
Breast Neoplasms
Inhibition of steroid sulphatase activity by steroidal methylthiophosphonates: potential therapeutic agents in breast cancer.
Breast Neoplasms
Inhibition of steroid sulphatase activity via the percutaneous route: a new option for breast cancer therapy.
Breast Neoplasms
Intracrine mechanism of estrogen synthesis in breast cancer.
Breast Neoplasms
Intracrinology of breast microenvironment: hormonal status in nipple aspirate fluid and its relationship to breast cancer.
Breast Neoplasms
Intratumoural mRNA expression of genes from the oestradiol metabolic pathway and clinical and histopathological parameters of breast cancer.
Breast Neoplasms
IPET study: an FLT-PET window study to assess the activity of the steroid sulfatase inhibitor irosustat in early breast cancer.
Breast Neoplasms
IRIS study: a phase II study of the steroid sulfatase inhibitor Irosustat when added to an aromatase inhibitor in ER-positive breast cancer patients.
Breast Neoplasms
Irosustat: a first-generation steroid sulfatase inhibitor in breast cancer.
Breast Neoplasms
Lack of inhibition of placental estrone sulfatase and aromatase enzymes by vitamin D3 and its analogs.
Breast Neoplasms
Localization of Estrone Sulfatase in Human Breast Carcinomas.
Breast Neoplasms
Low salivary testosterone levels in patients with breast cancer.
Breast Neoplasms
Measurement of oestrone sulphatase activity in white blood cells to monitor in vivo inhibition of steroid sulphatase activity by oestrone-3-O-sulphamate.
Breast Neoplasms
Molecular epidemiology of breast cancer: genetic variation in steroid hormone metabolism.
Breast Neoplasms
Norelgestromin as selective estrogen enzyme modulator in human breast cancer cell lines. Effect on sulfatase activity in comparison to medroxyprogesterone acetate.
Breast Neoplasms
Paradoxical effect of estradiol: it can block its own bioformation in human breast cancer cells.
Breast Neoplasms
Phase I Study of STX 64 (667 Coumate) in Breast Cancer Patients: The First Study of a Steroid Sulfatase Inhibitor.
Breast Neoplasms
Postmenopausal breast cancer risk in relation to sex steroid hormones, prolactin and SHBG (Sweden).
Breast Neoplasms
Postmenopausal plasma sex hormone levels and breast cancer risk over 20 years of follow-up.
Breast Neoplasms
Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition.
Breast Neoplasms
Potent active site-directed inhibition of steroid sulphatase by tricyclic coumarin-based sulphamates.
Breast Neoplasms
Pre-diagnostic sex hormone levels and survival among breast cancer patients.
Breast Neoplasms
Progestins and breast cancer.
Breast Neoplasms
Prognostic significance of aromatase and estrone sulfatase enzymes in human breast cancer.
Breast Neoplasms
Quantitative analysis of aromatase, sulfatase and 17beta-HSD(1) mRNA expression in soft tissue metastases of breast cancer.
Breast Neoplasms
Recent advances in the development of steroid sulphatase inhibitors.
Breast Neoplasms
Recent insight on the control of enzymes involved in estrogen formation and transformation in human breast cancer.
Breast Neoplasms
Regulation and inhibition of steroid sulfatase activity in breast cancer.
Breast Neoplasms
Regulation of steroid sulphatase and oestradiol 17 beta-hydroxysteroid dehydrogenase in breast cancer.
Breast Neoplasms
Regulation of steroid sulphatase expression and activity in breast cancer.
Breast Neoplasms
Relation of serum levels of testosterone and dehydroepiandrosterone sulfate to risk of breast cancer in postmenopausal women.
Breast Neoplasms
Relationship of serum dehydroepiandrosterone (DHEA), DHEA sulfate, and 5-androstene-3 beta, 17 beta-diol to risk of breast cancer in postmenopausal women.
Breast Neoplasms
Review of estrone sulfatase and its inhibitors--an important new target against hormone dependent breast cancer.
Breast Neoplasms
Role of steroid sulfatase in local formation of estrogen in post-menopausal breast cancer patients.
Breast Neoplasms
Role, control and expression of estrone sulfatase and 17 beta-hydroxysteroid dehydrogenase activities in human breast cancer.
Breast Neoplasms
Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC).
Breast Neoplasms
Sex steroid-producing enzymes in human breast cancer.
Breast Neoplasms
Shikonin, an ingredient of Lithospermum erythrorhizon, down-regulates the expression of steroid sulfatase genes in breast cancer cells.
Breast Neoplasms
Shu-Gan-Liang-Xue Decoction Simultaneously Down-regulates Expressions of Aromatase and Steroid Sulfatase in Estrogen Receptor Positive Breast Cancer Cells.
Breast Neoplasms
Shu-Gan-Liang-Xue Decoction, a Chinese herbal formula, down-regulates the expression of steroid sulfatase genes in human breast carcinoma MCF-7 cells.
Breast Neoplasms
Significance of Steroid Sulfatase Expression in Human Breast Cancer.
Breast Neoplasms
Steroid hormones and human breast cancer. An hypothesis.
Breast Neoplasms
Steroid sulfatase activities in human breast tumors.
Breast Neoplasms
Steroid sulfatase and estrogen sulfotransferase in human prostate cancer.
Breast Neoplasms
Steroid sulfatase and estrogen sulfotransferase in normal human tissue and breast carcinoma.
Breast Neoplasms
Steroid sulfatase expression is an independent predictor of recurrence in human breast cancer.
Breast Neoplasms
Steroid sulfatase in breast carcinoma and change of serum estrogens levels after operation.
Breast Neoplasms
Steroid sulfatase inhibition success and limitation in breast cancer clinical assays: An underlying mechanism.
Breast Neoplasms
Steroid sulfatase inhibitors: promising new therapy for breast cancer.
Breast Neoplasms
Steroid sulfatase inhibitors: Promising new tools for breast cancer therapy?
Breast Neoplasms
Steroid sulfatase inhibitors: their potential in the therapy of breast cancer.
Breast Neoplasms
Steroid sulfatase: a new target for the endocrine therapy of breast cancer.
Breast Neoplasms
Steroid sulphatase inhibitors for breast cancer therapy.
Breast Neoplasms
Steroidal and nonsteroidal sulfamates as potent inhibitors of steroid sulfatase.
Breast Neoplasms
Steroidal oxathiazine inhibitors of estrone sulfatase.
Breast Neoplasms
Stilbene-based inhibitors of estrone sulfatase with a dual mode of action in human breast cancer cells.
Breast Neoplasms
Stimulation of MCF-7 breast cancer cell proliferation by estrone sulfate and dehydroepiandrosterone sulfate: inhibition by novel non-steroidal steroid sulfatase inhibitors.
Breast Neoplasms
Structure Based Design, Synthesis, And Evaluation Of Potential Inhibitors Of Steroid Sulfatase.
Breast Neoplasms
Structure of human estrone sulfatase suggests functional roles of membrane association.
Breast Neoplasms
Sulfamoyloxy-substituted 2-phenylindoles: antiestrogen-based inhibitors of the steroid sulfatase in human breast cancer cells.
Breast Neoplasms
Sulfatase inhibitors for recidivist breast cancer treatment: A chemical review.
Breast Neoplasms
Sulfatase inhibitors: a patent review.
Breast Neoplasms
Synthesis and biological activity of the superestrogen (E)-17-oximino-3-O-sulfamoyl-1,3,5(10)-estratriene: x-ray crystal structure of (E)-17-oximino-3-hydroxy-1,3,5(10)-estratriene.
Breast Neoplasms
Synthesis and biological evaluation of thiophosphate tricyclic coumarin derivatives as steroid sulfatase inhibitors.
Breast Neoplasms
Synthesis and sulfatase inhibitory activities of (E)- and (Z)-4-hydroxytamoxifen sulfamates.
Breast Neoplasms
The association of plasma DHEA and DHEA sulfate with breast cancer risk in predominantly premenopausal women.
Breast Neoplasms
The development of A-ring modified analogues of oestrone-3-O-sulphamate as potent steroid sulphatase inhibitors with reduced oestrogenicity.
Breast Neoplasms
The effects of 2-methoxyoestrogen sulphamates on the in vitro and in vivo proliferation of breast cancer cells.
Breast Neoplasms
The influence of inflammatory cytokines on estrogen production and cell proliferation in human breast cancer cells.
Breast Neoplasms
The role of cytokines and sulphatase inhibitors in regulating oestrogen synthesis in breast tumours.
Breast Neoplasms
Tissue-specific transcripts of human steroid sulfatase are under control of estrogen signaling pathways in breast carcinoma.
Breast Neoplasms
Understanding the biologic mechanisms responsible for breast-cancer progression during tamoxifen or fulvestrant treatment.
Breast Neoplasms
Uptake and concentration of steroid hormones in mammary tissues.
Breast Neoplasms
Using molecular docking to investigate the anti-breast cancer activity of low molecular weight compounds present on wild mushrooms.
Breast Neoplasms
[Actions of a 19-norprogesterone derivative on mammary gland: nomegestrol acetate]
Breast Neoplasms
[Genetic polymorphism and variability of steroid hormone metabolism: connection with risk of developing breast neoplasms]
Breast Neoplasms
[Local production of estrogen via aromatase and estrone sulfatase in breast cancer tissue]
Breast Neoplasms
[Steroid sulfatase inhibitor]
Campomelic Dysplasia
Prenatal diagnosis of sex differentiation disorders: the role of fetal ultrasound.
Carcinogenesis
Detection of a novel, primate-specific 'kill switch' tumor suppression mechanism that may fundamentally control cancer risk in humans: an unexpected twist in the basic biology of TP53.
Carcinogenesis
Detection of a novel, primate-specific kill switch tumor suppression mechanism that may fundamentally control cancer risk in humans: an unexpected twist in the basic biology of TP53
Carcinogenesis
Human steroid sulfatase enhances aerobic glycolysis through induction of HIF1? and glycolytic enzymes.
Carcinogenesis
Induction of steroid sulfatase expression in PC-3 human prostate cancer cells by insulin-like growth factor II.
Carcinoma
Adrenal incidentaloma: an overview of hormonal data from the National Italian Study Group.
Carcinoma
Clinicopathological Significance of Estrogen Receptor ? and Estrogen Synthesizing/Metabolizing Enzymes in Urothelial Carcinoma of Urinary Bladder.
Carcinoma
In situ steroid sulfatase activity in human epithelial carcinoma cells of vaginal, ovarian, and endometrial origin.
Carcinoma
Increased serum cortisol levels are associated with high tumour grade in patients with renal cell carcinoma.
Carcinoma
Localization of Estrone Sulfatase in Human Breast Carcinomas.
Carcinoma
Serum dehydroepiandrosterone and dehydroepiandrosterone sulfate and risk of melanoma or squamous cell carcinoma of the skin.
Carcinoma
Serum levels of steroid sulfatase protein in gynecologic carcinomas.
Carcinoma
Steroid sulfatase and estrogen sulfotransferase in colon carcinoma: regulators of intratumoral estrogen concentrations and potent prognostic factors.
Carcinoma
Steroid sulfatase and estrogen sulfotransferase in human carcinomas.
Carcinoma
Steroid sulfatase and estrogen sulfotransferase in human endometrial carcinoma.
Carcinoma
Steroid sulphatase and oestrogen sulphotransferase in human non-small-cell lung carcinoma.
Carcinoma
Steroid-converting enzymes in human ovarian carcinomas.
Carcinoma
Sulfamoyloxy-substituted 2-phenylindoles: antiestrogen-based inhibitors of the steroid sulfatase in human breast cancer cells.
Carcinoma
Sulfatase Activity in Normal and Neoplastic Endometrium.
Carcinoma
[Biochemical study on steroid sulfatase and its clinical application to the obstetrics and gynecology]
Carcinoma, Endometrioid
Sulfatase Activity in Normal and Neoplastic Endometrium.
Carcinoma, Endometrioid
[Biochemical study on steroid sulphatase in the endometrioid adenocarcinoma]
Carcinoma, Hepatocellular
[Molecular mechanisms of DHEA and DHEAs on apoptosis and cell cycle arrest via Akt pathway in hepatoma cell lines]
Carcinoma, Intraductal, Noninfiltrating
Intratumoral concentration of sex steroids and expression of sex steroid-producing enzymes in ductal carcinoma in situ of human breast.
Carcinoma, Non-Small-Cell Lung
Steroid sulphatase and oestrogen sulphotransferase in human non-small-cell lung carcinoma.
Carcinoma, Ovarian Epithelial
Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Steroid-converting enzymes in human ovarian carcinomas.
Carcinoma, Renal Cell
Increased serum cortisol levels are associated with high tumour grade in patients with renal cell carcinoma.
Carcinoma, Squamous Cell
Serum dehydroepiandrosterone and dehydroepiandrosterone sulfate and risk of melanoma or squamous cell carcinoma of the skin.
Cardiomyopathy, Dilated
Dehydroepiandrosterone levels vary according as heart failure condition in patients with idiopathic dilated cardiomyopathy.
Cardiovascular Diseases
A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease.
Cardiovascular Diseases
Adrenal androgen dehydroepiandrosterone sulfate inhibits vascular remodeling following arterial injury.
Cardiovascular Diseases
Biotransformation of oral dehydroepiandrosterone in elderly men: significant increase in circulating estrogens.
Cardiovascular Diseases
Cardiovascular disease is associated with greater incident dehydroepiandrosterone sulfate decline in the oldest old: the cardiovascular health study all stars study.
Cardiovascular Diseases
Cardiovascular Risk Factors and Dehydroepiandrosterone Sulfate Among Latinos in the Boston Puerto Rican Health Study.
Cardiovascular Diseases
Clinical correlates of sex steroids and gonadotropins in men over the late adulthood: the Framingham Heart Study.
Cardiovascular Diseases
Dehydroepiandrosterone sulphate (DHEAS) in the oldest old, aged 85 and over.
Cardiovascular Diseases
Dehydroepiandrosterone, dehydroepiandrosterone sulphate and cardiovascular disease.
Cardiovascular Diseases
DHEA(S): the fountain of youth.
Cardiovascular Diseases
Differential effect of carbamazepine and valproate monotherapy on plasma levels of oestrone sulphate and dehydroepiandrosterone sulphate in male epileptic patients.
Cardiovascular Diseases
Distribution of dehydroepiandrosterone sulfate and relationships between its level and serum lipid levels in a rural Japanese population.
Cardiovascular Diseases
Effect of moderate alcohol consumption on plasma dehydroepiandrosterone sulfate, testosterone, and estradiol levels in middle-aged men and postmenopausal women: a diet-controlled intervention study.
Cardiovascular Diseases
Effects of age, smoking and vitamins on plasma DHEAS levels: a cross-sectional study in men.
Cardiovascular Diseases
Effects of dehydroepiandrosterone sulfate on cellular calcium responsiveness and vascular contractility.
Cardiovascular Diseases
Increased visceral adipose tissue is associated with increased circulating insulin and decreased sex hormone binding globulin levels in massively obese adolescent girls.
Cardiovascular Diseases
Inhibition of vascular inflammation by dehydroepiandrosterone sulfate in human aortic endothelial cells: Roles of PPARalpha and NF-kappaB.
Cardiovascular Diseases
Measurement of serum levels of dehydroepiandrosterone sulfate: a comparison of radioimmunoassay and enzymatic analysis.
Cardiovascular Diseases
Prognostic Value of Dehydroepiandrosterone Sulfate for Patients With Cardiovascular Disease: A Systematic Review and Meta-Analysis.
Cardiovascular Diseases
Relation of dehydroepiandrosterone and dehydroepiandrosterone sulfate with cardiovascular disease risk factors in women: longitudinal results from the Massachusetts Women's Health Study.
Cardiovascular Diseases
Serum dehydroepiandrosterone levels are associated with lower risk of type 2 diabetes: the Rotterdam Study.
Cardiovascular Diseases
The epidemiology of DHEAS and cardiovascular disease.
Cardiovascular Diseases
[The relationship between serum dehydroepiandrosterone sulfate levels and factors associated with cardiovascular diseases: a cross-sectional study in Japan]
Carotid Artery Diseases
Dehydroepiandrosterone sulfate is inversely associated with sex-dependent diverse carotid atherosclerosis regardless of endothelial function.
Cataract
Relationships between hormonal status and cataract in french postmenopausal women: the POLA study.
Cerebral Infarction
The effect of dehydroepiandrosterone sulfate administration to patients with multi-infarct dementia.
Cholestasis
Transgenic Overexpression of Steroid Sulfatase Alleviates Cholestasis.
Cholestasis, Intrahepatic
Stable prolactin level after enhanced estradiol production following dehydroepiandrosterone sulfate.
Chondrodysplasia Punctata
Contiguous gene syndromes due to deletions in the distal short arm of the human X chromosome.
Chondrodysplasia Punctata
Deletion of the distal short arm of the X chromosome (Xp) in a patient with short stature, chondrodysplasia punctata, and X-linked ichthyosis due to steroid sulfatase deficiency.
Chondrodysplasia Punctata
Long-range restriction map of the terminal part of the short arm of the human X chromosome.
Chondrodysplasia Punctata
Prenatal diagnosis and investigation of a fetus with chondrodysplasia punctata, ichthyosis, and Kallmann syndrome due to an Xp deletion.
Chondrodysplasia Punctata
Role of the pseudoautosomal region in sex-chromosome pairing during male meiosis: meiotic studies in a man with a deletion of distal Xp.
Chondrodysplasia Punctata
X-linked dominant chondrodysplasia punctata with decreased dihydroxyacetone phosphate acyltransferase activity.
Chondrodysplasia Punctata
X/Y translocation in a family with X-linked ichthyosis, chondrodysplasia punctata, and mental retardation: DNA analysis reveals deletion of the steroid sulphatase gene and translocation of its Y pseudogene.
Choriocarcinoma
Estrogen production as a tumor marker in patients with gonadotropin-producing neoplasms.
Choriocarcinoma
Expression of 17beta-hydroxysteroid dehydrogenases and other estrogen-metabolizing enzymes in different cancer cell lines.
Choriocarcinoma
In vitro and in vivo models for the evaluation of new inhibitors of human steroid sulfatase, devoid of residual estrogenic activity.
Choriocarcinoma
Role of OAT4 in Uptake of Estriol Precursor 16?-Hydroxydehydroepiandrosterone Sulfate Into Human Placental Syncytiotrophoblasts From Fetus.
Chromosome Disorders
Are low maternal estriol levels a predictor for pro-opiomelanocortin (POMC) deficiency caused by POMC mutation during pregnancy?
Coinfection
Low plasma levels of dehydroepiandrosterone sulphate in HIV-positive patients coinfected with hepatitis C virus.
Colitis, Ulcerative
Association of dehydroepiandrosterone sulfate and testosterone deficiency with bone turnover in men with inflammatory bowel disease.
Colitis, Ulcerative
Association of humoral markers of inflammation and dehydroepiandrosterone sulfate or cortisol serum levels in patients with chronic inflammatory bowel disease.
Colitis, Ulcerative
Blood and tissue dehydroepiandrosterone sulphate levels and their relationship to chronic inflammatory bowel disease.
Colonic Neoplasms
Serum dehydroepiandrosterone and dehydroepiandrosterone sulfate and the subsequent risk of developing colon cancer.
Colonic Neoplasms
[Molecular mechanisms of DHEA and DHEAs on apoptosis and cell cycle arrest via Akt pathway in hepatoma cell lines]
Colorectal Neoplasms
Estrogen Activation by Steroid Sulfatase increases Colorectal Cancer proliferation via GPER.
Colorectal Neoplasms
Estrone Sulfate Transport and Steroid Sulfatase Activity in Colorectal Cancer: Implications for Hormone Replacement Therapy.
Colorectal Neoplasms
Reduced expression of steroid sulfatase in primary colorectal cancer.
Coma
Reduced brain levels of DHEAS in hepatic coma patients: significance for increased GABAergic tone in hepatic encephalopathy.
Corneal Dystrophies, Hereditary
Pre-Descemet corneal dystrophy and X-linked ichthyosis associated with deletion of Xp22.31 containing the STS gene.
Corneal Opacity
Characterization of low-density lipoproteins from patients with recessive X-linked ichthyosis.
Corneal Opacity
Clinical pathologic correlation of superficial corneal opacities in X-linked ichthyosis.
Corneal Opacity
X-linked recessive ichthyosis.
Coronary Artery Disease
Dehydroepiandrosterone and coronary atherosclerosis.
Coronary Artery Disease
Dehydroepiandrosterone sulfate induces acute vasodilation of porcine coronary arteries in vitro and in vivo.
Coronary Artery Disease
Plasma levels of estradiol, testosterone, and DHEAS do not predict risk of coronary artery disease in men.
Coronary Artery Disease
Serum DHEAS levels correlate with platelet cGMP in normal women.
Coronary Artery Disease
[Dehydroepiandrosterone (DHEA)--slows down the aging process?]
Coronary Disease
Are low dehydroepiandrosterone sulphate levels predictive for cardiovascular diseases? A review of prospective and retrospective studies.
Coronary Disease
Association of endogenous DHEA/DHEAS with coronary heart disease: A systematic review and meta-analysis.
Coronary Disease
Dehydroepiandrosterone sulfate and the risk of myocardial infarction in US male physicians: a prospective study.
Coronary Disease
Dehydroepiandrosterone sulfate does not predict cardiovascular death in postmenopausal women. The Rancho Bernardo Study.
Coronary Disease
Dehydroepiandrosterone sulfate, incidence of myocardial infarction, and extent of atherosclerosis in men.
Coronary Disease
Dehydroepiandrosterone, dehydroepiandrosterone sulphate and cardiovascular disease.
Coronary Disease
[Dehydroepiandrosterone therapy in men with angiographically verified coronary heart disease: the effects on plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (tPA) and fibrinogen plasma concentrations.]
COVID-19
Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?
Crohn Disease
Association of humoral markers of inflammation and dehydroepiandrosterone sulfate or cortisol serum levels in patients with chronic inflammatory bowel disease.
Crohn Disease
Blood and tissue dehydroepiandrosterone sulphate levels and their relationship to chronic inflammatory bowel disease.
Cryptorchidism
Clinical spectrum of steroid sulfatase deficiency: X-linked recessive ichthyosis, birth complications and cryptorchidism.
Cryptorchidism
End-stage renal failure in a child with X-linked ichthyosis.
Cryptorchidism
Nonsyndromic types of ichthyoses - an update.
Cryptorchidism
X-linked recessive ichthyosis.
Cryptorchidism
[Steroid sulfatase and placental deficiency. Current data as instigators of new research]
Cushing Syndrome
A case of Cushing's syndrome due to bilateral cortisol-secreting adenomas with unilateral DHEAS oversecretion.
Cushing Syndrome
A case of pheochromocytoma with negative MIBG scintigraphy, PET-CT and genetic tests (VHL included) and a rare case of post-operative erectile dysfunction.
Cushing Syndrome
Body composition in pituitary, adrenal and iatrogenic Cushing's syndrome and effects of DHEAS levels.
Cushing Syndrome
DHEAS for the prediction of subclinical Cushing's syndrome: perplexing or advantageous?
Cushing Syndrome
Effects of sex steroids on bone in women with subclinical or overt endogenous hypercortisolism.
Cushing Syndrome
Isolated dehydroepiandrosterone sulphate hypersecretion: a case report.
Cushing Syndrome
Laparoscopic adrenalectomy. The importance of a flank approach in the lateral decubitus position.
Cushing Syndrome
Low DHEAS: A Sensitive and Specific Test for the Detection of Subclinical Hypercortisolism in Adrenal Incidentalomas.
Cushing Syndrome
Reduced serum levels of dehydroepiandrosterone sulphate in adrenal incidentalomas: a marker of adrenocortical tumour.
Cushing Syndrome
THE EVALUATION OF INCIDENTALLY DISCOVERED ADRENAL MASSES.
Cysts
Accumulation of 4- and 5-ene steroid sulfates in human breast cyst fluids.
Cysts
Laparoscopic adrenalectomy. The importance of a flank approach in the lateral decubitus position.
Cysts
Plasma dehydroepiandrosterone sulfate levels in patients with hyperfunctioning and non-hyperfunctioning adrenal tumors before and after adrenal surgery.
Deficiency Diseases
Steroid sulphatase deficiency disease.
Dementia
A prospective study of dehydroepiandrosterone sulfate and cognitive function in an older population: the Rancho Bernardo Study.
Dementia
Cognitive and affective disorders in the elderly: a neuroendocrine study.
Dementia
Dehydroepiandrosterone (DHEA) supplementation for cognition and well-being.
Dementia
Dehydroepiandrosterone (DHEA) supplementation for cognitive function .
Dementia
Dehydroepiandrosterone sulfate, diseases and mortality in a general aged population.
Dementia
Dehydroepiandrosterone-sulfate serum levels and common age-related diseases: results from a cross-sectional Italian study of a general elderly population.
Dementia
Growth factors decrease in subjects with mild to moderate Alzheimer's disease (AD): potential correction with dehydroepiandrosterone-sulphate (DHEAS).
Dementia
Hippocampal perfusion and pituitary-adrenal axis in Alzheimer's disease.
Dementia
Neurosteroids: Cerebrospinal fluid levels for Alzheimer's disease and vascular dementia diagnostics.
Dementia
Pineal and pituitary-adrenocortical function in physiological aging and in senile dementia.
Dementia
Plasma testosterone, dehydroepiandrosterone sulfate, and cortisol in female patients with Huntington's disease.
Dementia
Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: a French community-based study.
Dementia
Serum dehydroepiandrosterone sulfate in Alzheimer's disease and in multi-infarct dementia.
Dementia
WITHDRAWN: Dehydroepiandrosterone (DHEA) supplementation for cognitive function.
Dementia, Vascular
Neurosteroids: Cerebrospinal fluid levels for Alzheimer's disease and vascular dementia diagnostics.
Dermatitis, Atopic
Steroid concentrations in atopic dermatitis patients: Reduced plasma DHEAS and increased cortisone levels.
Dermatitis, Contact
Relationship between humoral immunoaugmenting properties of DHEAS and IgD-receptor expression in young and aged mice.
Diabetes Mellitus
Association of decrease in serum dehydroepiandrosterone sulfate levels with the progression to type 2 diabetes in men of a Japanese population: the Funagata Study.
Diabetes Mellitus
Dehydroepiandrosterone sulfate, diseases and mortality in a general aged population.
Diabetes Mellitus
DHEA, DHEAS and prolactin correlate with glucose control parameters in women of fertile age with type-1 diabetes mellitus.
Diabetes Mellitus
Independent association between insulin-like growth factor-I and dehydroepiandrosterone sulphate in women in middle adulthood.
Diabetes Mellitus
[A relationship between dehydroepiandrosterone sulphate and insulin resistance in obese men and women]
Diabetes Mellitus
[Low levels of dehydroepiandrosterone sulfate in adult males with insulin-dependent diabetes mellitus]
Diabetes Mellitus, Type 1
Dehydroepiandrosterone sulfate does not prevent spontaneous and iodine-induced lymphocytic thyroiditis and diabetes mellitus in the BB/Wor rat.
Diabetes Mellitus, Type 1
[Low levels of dehydroepiandrosterone sulfate in adult males with insulin-dependent diabetes mellitus]
Diabetes Mellitus, Type 2
Association of decrease in serum dehydroepiandrosterone sulfate levels with the progression to type 2 diabetes in men of a Japanese population: the Funagata Study.
Diabetes Mellitus, Type 2
Dietary composition affects regional body fat distribution and levels of dehydroepiandrosterone sulphate (DHEAS) in post-menopausal women with Type 2 diabetes.
Diabetes Mellitus, Type 2
Hepatic Overexpression of Steroid Sulfatase Ameliorates Mouse Models of Obesity and Type 2 Diabetes through Sex-specific Mechanisms.
Diabetes Mellitus, Type 2
Serum dehydroepiandrosterone levels are associated with lower risk of type 2 diabetes: the Rotterdam Study.
Diabetes Mellitus, Type 2
Serum Dehydroepiandrosterone Sulfate and Risk for Type 2 Diabetes in Older Men and Women: The Pro.V.A Study.
Diabetes Mellitus, Type 2
[A relationship between dehydroepiandrosterone sulphate and insulin resistance in obese men and women]
Disorder of Sex Development, 46,XY
Prenatal diagnosis of sex differentiation disorders: the role of fetal ultrasound.
Down Syndrome
Advances in prenatal screening for Down syndrome: I. general principles and second trimester testing.
Down Syndrome
Placental synthesis of oestriol in Down's syndrome pregnancies.
Dwarfism, Pituitary
Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males.
Dyslipidemias
Dehydroepiandrosterone Sulfate (DHEAS) Levels in Polycystic Ovarian Syndrome (PCOS).
Dysostoses
Ichthyosis: the skin manifestation of multiple sulfatase deficiency.
Dyspnea
Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: a French community-based study.
Encephalitis
Neuroprotective Effects of Dehydroepiandrosterone Sulfate Through Inhibiting Expression of Matrix Metalloproteinase-9 from Bradykinin-Challenged Astroglia.
Endometrial Hyperplasia
Estrone sulfatase activity in normal and abnormal endometrium.
Endometrial Hyperplasia
In situ estrogen metabolism in proliferative endometria from untreated women with polycystic ovarian syndrome with and without endometrial hyperplasia.
Endometrial Neoplasms
Circulating levels of sex steroid hormones and risk of endometrial cancer in postmenopausal women.
Endometrial Neoplasms
Estrogen formation in endometrial and cervix cancer cell lines: Involvement of aromatase, steroid sulfatase and 17beta-hydroxysteroid dehydrogenases (types 1, 5, 7 and 12).
Endometrial Neoplasms
Expression of 17beta-hydroxysteroid dehydrogenases and other estrogen-metabolizing enzymes in different cancer cell lines.
Endometrial Neoplasms
Steroid sulfatase and estrogen sulfotransferase in human endometrial carcinoma.
Endometrial Neoplasms
Steroid sulfatase: A pivotal player in estrogen synthesis and metabolism.
Endometrial Neoplasms
The Role of Steroid Sulfatase as a Prognostic Factor in Patients with Endometrial Cancer.
Endometrial Neoplasms
The sulfatase pathway as estrogen supply in endometrial cancer.
Endometrial Neoplasms
The use of steroid sulfatase inhibitors as a novel therapeutic strategy against hormone-dependent endometrial cancer.
Endometrial Neoplasms
[Biochemical study on steroid sulfatase and its clinical application to the obstetrics and gynecology]
Endometrial Neoplasms
[Prognostic significance of assay of sex hormones, their receptors and enzymes involved in estrogen synthesis and metabolism in endometrial carcinoma]
Endometriosis
Effects of steroid hormone on estrogen sulfotransferase and on steroid sulfatase expression in endometriosis tissue and stromal cells.
Endometriosis
Estrogen metabolizing enzymes in endometrium and endometriosis.
Endometriosis
Gonadotropin-releasing hormone agonist inhibits estrone sulfatase expression of cystic endometriosis in the ovary.
Endometriosis
Inhibition of steroid sulfatase decreases endometriosis in an in vivo murine model.
Endometriosis
Inhibition of steroid sulphatase activity in endometriotic implants by 667 COUMATE: a potential new therapy.
Endometriosis
Oncological markers CA-125, CA 19-9 and endometriosis.
Endometriosis
Strong expression of steroid sulfatase in human cumulus cells in patients with endometriosis.
Endometriosis
Sulfatase inhibitors: a patent review.
Endometriosis
SULFATION PATHWAYS: Contribution of intracrine oestrogens to the aetiology of endometriosis.
Endometriosis
Synergistic Effects of E2MATE and Norethindrone Acetate on Steroid Sulfatase Inhibition: A Randomized Phase I Proof-of-Principle Clinical Study in Women of Reproductive Age.
Epidermolysis Bullosa Simplex
Recurrent bilateral corneal erosions due to an association of epidermolysis bullosa simplex Köbner and X-linked ichthyosis with steroid sulfatase deficiency.
Epilepsy
Effects of valproate and carbamazepine monotherapy on neuroactive steroids, their precursors and metabolites in adult men with epilepsy.
Epilepsy
Effects of valproate on reproductive endocrine function in male patients with epilepsy: A systematic review and meta-analysis.
Epilepsy
Physical growth and endocrinal disorders during pubertal maturation in girls with epilepsy.
Epilepsy
Seizure frequency and cortisol and dehydroepiandrosterone sulfate (DHEAS) levels in women with epilepsy receiving antiepileptic drug treatment.
Epileptic Syndromes
Seizure frequency and cortisol and dehydroepiandrosterone sulfate (DHEAS) levels in women with epilepsy receiving antiepileptic drug treatment.
Erectile Dysfunction
Are dehydroepiandrosterone sulphate and lipids associated with erectile dysfunction?
Erectile Dysfunction
The Relationships of Dehydroepiandrosterone Sulfate, Erectile Function and General Psychological Health.
Erythema
Lipids in the pathogenesis of ichthyosis: topical cholesterol sulfate-induced scaling in hairless mice.
Essential Hypertension
A close association between insulin resistance and dehydroepiandrosterone sulfate in subjects with essential hypertension.
Essential Hypertension
Clinical implications of genetic and acquired defects in catecholamine synthesis and metabolism.
Essential Hypertension
Relationship between blood pressure variability and serum dehydroepiandrosterone sulfate levels.
Euthyroid Sick Syndromes
Altered adrenal and thyroid function in children with insulin-dependent diabetes mellitus.
Fatigue Syndrome, Chronic
Levels of DHEA and DHEAS and responses to CRH stimulation and hydrocortisone treatment in chronic fatigue syndrome.
Fatty Liver
Dehydroepiandrosterone sulfate and cytochrome P450 inducers alleviate fatty liver in male rats fed an orotic acid-supplemented diet.
Fatty Liver
The association of dehydroepiandrosterone, obesity, waist-hip ratio and insulin resistance with fatty liver in postmenopausal women--a hyperinsulinemic euglycemic insulin clamp study.
Fetal Death
Advances in prenatal screening for Down syndrome: I. general principles and second trimester testing.
Fetal Death
Maternal serum unconjugated estriol as a predictor for Smith-Lemli-Opitz syndrome and other fetal conditions.
Fetal Growth Retardation
Serum dehydroepiandrosterone sulfate levels and pubarche in short children born small for gestational age before and during growth hormone treatment.
Fibromyalgia
During a corticotropin-releasing hormone test in healthy subjects, administration of a beta-adrenergic antagonist induced secretion of cortisol and dehydroepiandrosterone sulfate and inhibited secretion of ACTH.
Follicular Cyst
Isosexual pseudoprecocious puberty in a 2(1/2)-year-old girl presenting with intense skin pigmentation.
Fragile X Syndrome
A family with fragile X syndrome, Duchenne muscular dystrophy and ichthyosis transmitted by an asymptomatic carrier.
Genetic Diseases, Inborn
Male-pattern baldness in men with X-linked recessive ichthyosis.
Genetic Diseases, Inborn
Male-pattern baldness is common in men with X-linked recessive ichthyosis.
Genetic Diseases, Inborn
Mutations in X-linked ichthyosis disrupt the active site structure of estrone/DHEA sulfatase.
Genetic Diseases, Inborn
Placental steroid sulphatase deficiency: an approach to antenatal care and delivery.
Genetic Diseases, Inborn
Steroid sulfatase deficiency.
Genetic Diseases, Inborn
Xp22.3 interstitial deletion: A recognizable chromosomal abnormality encompassing VCX3A and STS genes in a patient with X-linked ichthyosis and mental retardation.
Genetic Diseases, Inborn
[Steroid sulfatase and placental deficiency. Current data as instigators of new research]
Giant Cell Arteritis
Low serum levels of DHEAS in untreated polymyalgia rheumatica/giant cell arteritis.
Glioma
Drug-induced differentiation of a rat glioma in vitro: II. the expression of S-100, a glial specific protein and steroid sulfatase.
Glucose Intolerance
Dehydroepiandrosterone, dehydroepiandrosterone sulfate, obesity, waist-hip ratio, and noninsulin-dependent diabetes in postmenopausal women: the Rancho Bernardo Study.
Goiter
Importance of Dehydroepiandrosterone Sulfate Assessment with Special Attention for Adrenal Tumours and Arterial Hypertension.
Guillain-Barre Syndrome
Neurosteroids in cerebrospinal fluid in neurologic disorders.
Gynecomastia
Leptin levels in boys with pubertal gynecomastia.
Heart Diseases
A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease.
Heart Diseases
Dehydroepiandrosterone (DHEA) levels in patients with prostatic cancer, heart diseases and under surgery stress.
Heart Diseases
Dehydroepiandrosterone sulfate does not predict cardiovascular death in postmenopausal women. The Rancho Bernardo Study.
Heart Diseases
Low dehydroepiandrosterone sulfate and heart disease in middle-aged men: cross-sectional results from the Massachusetts Male Aging Study.
Heart Failure
Dehydroepiandrosterone levels vary according as heart failure condition in patients with idiopathic dilated cardiomyopathy.
Heart Failure
During a corticotropin-releasing hormone test in healthy subjects, administration of a beta-adrenergic antagonist induced secretion of cortisol and dehydroepiandrosterone sulfate and inhibited secretion of ACTH.
Heart Failure
The plasma levels of dehydroepiandrosterone sulfate are decreased in patients with chronic heart failure in proportion to the severity.
Heart Failure
[A comparative survey of sex hormones levels between elderly men with chronic heart failure and normal elderly subjects]
Hepatic Encephalopathy
Reduced brain levels of DHEAS in hepatic coma patients: significance for increased GABAergic tone in hepatic encephalopathy.
Hepatitis B
Role of serum dehydroepiandrosterone sulfate level on the clearance of chronic hepatitis B virus infection.
Hepatitis B
The effect of endogenous dehydroepiandrosterone sulphate on antibody response to hepatitis B vaccine in neonates.
Hepatoblastoma
[Molecular mechanisms of DHEA and DHEAs on apoptosis and cell cycle arrest via Akt pathway in hepatoma cell lines]
Hepatomegaly
Effects of acute administration of dehydroepiandrosterone-sulfate on adipose tissue mass and cellularity in male rats.
Herpes Zoster
Adrenal androgens and aging.
Herpes Zoster
Adrenarche and the evolution of human life history.
Herpes Zoster
DHEAS and Human Development: An Evolutionary Perspective.
Herpes Zoster
Dissecting human adrenal androgen production.
Herpes Zoster
McCune-Albright Syndrome with Male Premature Pubarche of Unusual Origin.
Herpes Zoster
Neurosteroid transport by the organic solute transporter OST?-OST?.
Herpes Zoster
Novel presence of luteinizing hormone/chorionic gonadotropin receptors in human adrenal glands.
Herpes Zoster
Premature adrenarche: novel lessons from early onset androgen excess.
Herpes Zoster
Selective increases in adrenal steroidogenic capacity during acute respiratory disease in infants.
Hirsutism
Androgen dependence of hirsutism, acne, and alopecia in women: retrospective analysis of 228 patients investigated for hyperandrogenism.
Hirsutism
Association between biochemical hyperandrogenism parameters and Ferriman-Gallwey score in patients with polycystic ovary syndrome: A systematic review and meta-regression analysis.
Hirsutism
CAG repeat polymorphism in androgen receptor gene is not directly associated with polycystic ovary syndrome but influences serum testosterone levels.
Hirsutism
Clinical efficacy of lower dose flutamide 125 mg/day in the treatment of hirsutism.
Hirsutism
Clomiphene citrate and dexamethazone in treatment of clomiphene citrate-resistant polycystic ovary syndrome: a prospective placebo-controlled study.
Hirsutism
Correlation of Cutaneous Manifestations with Body Mass Index, Blood Glucose, and Hormonal Levels in Patients with Polycystic Ovarian Disease.
Hirsutism
Cushing's syndrome: new variants and association with empty sella syndrome.
Hirsutism
Effects of Metformin Treatment on Soluble Leptin Receptor Levels in Women with Polycystic Ovary Syndrome.
Hirsutism
Finasteride in the treatment of hirsutism: new therapeutic perspectives.
Hirsutism
Finasteride treatment for one year in 35 hirsute patients.
Hirsutism
First Report of Retroperitoneal Mucinous Cystadenoma in a Patient with Hirsutism.
Hirsutism
Idiopathic hirsutism: an uncommon cause of hirsutism in Alabama.
Hirsutism
Impact of adrenal versus ovarian androgen ratio on signs and symptoms of polycystic ovarian syndrome.
Hirsutism
Marked hyperandrogenicity in a 60-year-old woman.
Hirsutism
Metformin therapy decreases hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome.
Hirsutism
Modified Ferriman-Gallwey hirsutism score and androgen levels in Turkish women.
Hirsutism
Phenotypic spectrum of polycystic ovary syndrome: clinical and biochemical characterization of the three major clinical subgroups.
Hirsutism
Predictive value of glucose-insulin ratio in PCOS and profile of women who will benefit from metformin therapy: obese, lean, hyper or normoinsulinemic?
Hirsutism
Screening for Androgen Excess in Women: Accuracy of Self-Reported Excess Body Hair Growth and Menstrual Dysfunction.
Hirsutism
Serum levels of DHEAS in gynecologic endocrinopathy and infertility.
Hirsutism
Sibutramine has a positive effect on clinical and metabolic parameters in obese patients with polycystic ovary syndrome.
Hirsutism
Steroid sulfatase in the human hair follicle concentrates in the dermal papilla.
Hirsutism
The effect of dehydroepiandrosterone sulfate prolactin and testosterone hormones in female fertility and hirsutism.
Hirsutism
The effect of probiotics, prebiotics, and synbiotics on hormonal and inflammatory indices in women with polycystic ovary syndrome: a systematic review and meta-analysis.
Hirsutism
The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism.
Hirsutism
The Hirsute Woman: Challenges in the Evaluation and Management.
Hirsutism
The role and importance of auxiliary tests in differential diagnosis in patients with mildly high basal 17-oh-progesterone levels in the evaluation of hirsutism.
Hirsutism
Total testosterone and DHEAS levels as predictors of androgen-secreting neoplasms: a populational study.
Hirsutism
Treatment of hyperandrogenism and hyperinsulinemia in PCOS patients with essential aminoacids. A pilot clinical study.
Hirsutism
[Hirsutism and hypertrichosis in adults: investigations and treatment]
HIV Infections
Blood cortisol and dehydroepiandrosterone sulphate (DHEAS) levels and CD4 T cell counts in HIV infection.
HIV Infections
HIV-1 clade C infection and progressive disruption in the relationship between cortisol, DHEAS and CD4 cell numbers: a two-year follow-up study.
HIV Infections
Relationship between sex steroid hormone levels and CD4 lymphocytes in HIV infected men.
HIV Infections
Usefulness of alternate prognostic serum and plasma markers for antiretroviral therapy for human immunodeficiency virus type 1 infection.
Hydrocephalus
Second-trimester maternal serum screening using alpha-fetoprotein, human chorionic gonadotrophin, and unconjugated oestriol: experience of a regional programme.
Hyperaldosteronism
Asymptomatic adrenal tumours: criteria for endoscopic removal.
Hyperaldosteronism
Laparoscopic adrenalectomy. The importance of a flank approach in the lateral decubitus position.
Hyperalgesia
Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABA(A) receptors.
Hyperalgesia
Neurosteroid dehydroepiandrosterone sulphate enhances pain transmission in rat spinal cord dorsal horn.
Hyperalgesia
Peripheral neurosteroids enhance P2X receptor-induced mechanical allodynia via a sigma-1 receptor-mediated mechanism.
Hyperandrogenism
Adrenal androgen excess and body mass index in polycystic ovary syndrome.
Hyperandrogenism
Association of Luteinizing hormone and LH receptor gene polymorphism with susceptibility of Polycystic ovary syndrome.
Hyperandrogenism
Clinical features and hormonal characteristics in a case of ovarian arrhenoblastoma.
Hyperandrogenism
Clinical, endocrine, and metabolic effects of acarbose, a alpha-glucosidase inhibitor, in overweight and nonoverweight patients with polycystic ovarian syndrome.
Hyperandrogenism
Comparison of Two Statistical Methods to Determine Normal Range of Androgen Hormones: K-Means Cluster Analysis and Receiver Operating Characteristic Curve.
Hyperandrogenism
Differential response to adrenocorticotropin hormone stimulation in polycystic ovarian disease with high and low dehydroepiandrosterone sulfate levels.
Hyperandrogenism
Diurnal rhythm and effects of oral contraceptives on serum dehydroepiandrosterone sulfate (DHEAS) are related to alterations in serum albumin rather than to changes in adrenocortical steroid secretion.
Hyperandrogenism
High DHEAS Level in Girls Is Associated with Earlier Pubertal Maturation and Mild Increase in Androgens throughout Puberty without Affecting Postmenarche Ovarian Morphology.
Hyperandrogenism
Hirsutism in women. Effective therapy that is safe for long-term use.
Hyperandrogenism
Impact of rs2414096 polymorphism of CYP19 gene on susceptibility of polycystic ovary syndrome and hyperandrogenism in Kashmiri women.
Hyperandrogenism
Influence of adrenal hyperandrogenism on the clinical and metabolic phenotype of women with polycystic ovary syndrome.
Hyperandrogenism
Investigation of hypothalamo-pituitary-gonadal axis and glucose intolerance among the first-degree female relatives of women with polycystic ovary syndrome.
Hyperandrogenism
Lack of an ovarian function influence on the increased adrenal androgen secretion present in women with functional ovarian hyperandrogenism.
Hyperandrogenism
Leydig cell hyperplasia and Leydig cell tumour in postmenopausal women: report of two cases.
Hyperandrogenism
Low DHEAS Concentration in a Girl Presenting with Short Stature and Premature Pubarche: A Novel PAPSS2 Gene Mutation.
Hyperandrogenism
Modified Ferriman-Gallwey hirsutism score and androgen levels in Turkish women.
Hyperandrogenism
Ovarian morphology is associated with insulin resistance in women with polycystic ovary syndrome: a cross sectional study.
Hyperandrogenism
Ovarian suppression with triptorelin and adrenal stimulation with adrenocorticotropin in functional hyperadrogenism: role of adrenal and ovarian cytochrome P450c17 alpha.
Hyperandrogenism
Prevalence and metabolic characteristics of adrenal androgen excess in hyperandrogenic women with different phenotypes.
Hyperandrogenism
[Effect on skin and hormonal hyperandrogenic manifestations of an oral estroprogestin association containing ethynilestradiol 30 mg and drospirenone 3 mg]
Hypercholesterolemia
Increased cholesterol sulfate in plasma and red blood cell membranes of steroid sulfatase deficient patients.
Hypercholesterolemia
The epidemiology of DHEAS and cardiovascular disease.
Hyperglycemia
Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells.
Hyperglycemia
Hypothalamic-pituitary-adrenal-axis dysregulation and double product increases potentiate ischemic heart disease risk in a Black male cohort: the SABPA study.
Hyperglycemia
Impact of glycemic variations on the regulation of androgen metabolism in obese women with polycystic ovary syndrome.
Hyperglycemia
No acute effect of physiological insulin increase on dehydroepiandrosterone sulfate in women with obesity and/or polycystic ovarian disease.
Hyperinsulinism
Acute hyperinsulinemia, androgen homeostasis and insulin sensitivity in healthy man.
Hyperinsulinism
Dehydroepiandrosterone sulfate and insulin resistance in patients with polycystic ovary syndrome.
Hyperinsulinism
Effect of acute physiological elevations of insulin on circulating androgen levels in nonobese women.
Hyperinsulinism
Growth and pubertal development following pediatric heart transplantation: a 15-year experience at Ste-Justine Hospital.
Hyperinsulinism
Hyperinsulinemia is associated with menstrual irregularity and altered serum androgens in Pima Indian women.
Hyperinsulinism
Lack of effect of insulin or insulin-like growth factor I on the steroid sulfatase activity of human placental cytotrophoblasts.
Hyperinsulinism
No acute effect of physiological insulin increase on dehydroepiandrosterone sulfate in women with obesity and/or polycystic ovarian disease.
Hyperinsulinism
Prevention of high fructose-induced metabolic syndrome in male wistar rats by aqueous extract of Tamarindus indica seed.
Hyperinsulinism
Role of dehydroepiandrosterone sulfate levels on body composition after laparoscopic adjustable gastric banding in pre-menopausal morbidly obese women.
Hyperinsulinism
Serum soluble leptin receptor levels and free leptin index in women with polycystic ovary syndrome: relationship to insulin resistance and androgens.
Hyperinsulinism
Troglitazone decreases adrenal androgen levels in women with polycystic ovary syndrome.
Hyperinsulinism
Vanadyl sulfate ameliorates insulin resistance and restores plasma dehydroepiandrosterone-sulfate levels in fructose-fed, insulin-resistant rats.
Hyperinsulinism
[Androgen response in women with polycystic ovary syndrome and hyperinsulinemia during stimulation with corticotrophin and inhibition with dexamethasone]
Hyperinsulinism
[Hirsutism and hypertrichosis in adults: investigations and treatment]
Hyperinsulinism
[Low levels of dehydroepiandrosterone sulfate in adult males with insulin-dependent diabetes mellitus]
Hyperinsulinism
[Polycystic ovary and diazoxide. In vivo study]
Hyperlipoproteinemia Type II
Gonadal steroids, gonadotropins and DHEAS in young adults with familial hypercholesterolemia who had initiated statin therapy in childhood.
Hyperprolactinemia
Cushing's syndrome: new variants and association with empty sella syndrome.
Hyperprolactinemia
Effect of hyperprolactinemia on the androgen response to an oral glucose load.
Hypersensitivity
Neurosteroid dehydroepiandrosterone sulphate enhances pain transmission in rat spinal cord dorsal horn.
Hypertension
Activation of 11 beta-hydroxysteroid dehydrogenase by dehydroepiandrosterone sulphate as an anti-hypertensive agent in spontaneously hypertensive rats.
Hypertension
Analysis of relationships between the concentrations of total testosterone and dehydroepiandrosterone sulfate and the occurrence of selected metabolic disorders in aging men.
Hypertension
Cardiovascular disease is associated with greater incident dehydroepiandrosterone sulfate decline in the oldest old: the cardiovascular health study all stars study.
Hypertension
Cortisol, dehydroepiandrosterone sulphate, their ratio and hypertension: evidence of associations in male veterans from the Vietnam Experience Study.
Hypertension
Dehydroepiandrosterone sulfate in a long-term care aged population.
Hypertension
Hypothalamic-pituitary-adrenal-axis dysregulation and double product increases potentiate ischemic heart disease risk in a Black male cohort: the SABPA study.
Hypertension
Importance of Dehydroepiandrosterone Sulfate Assessment with Special Attention for Adrenal Tumours and Arterial Hypertension.
Hypertension
Left ventricular mass index and ventricular septum thickness are associated with serum dehydroepiandrosterone-sulphate levels in hypertensive women.
Hypertension
Low dehydroepiandrosterone and ischemic heart disease in middle-aged men: prospective results from the Massachusetts Male Aging Study.
Hypertension
Low dehydroepiandrosterone sulfate and heart disease in middle-aged men: cross-sectional results from the Massachusetts Male Aging Study.
Hypertension
Relation between dehydroepiandrosterone sulfate and blood pressure levels in a population-based sample.
Hypertension
Relationship between blood pressure variability and serum dehydroepiandrosterone sulfate levels.
Hypertension
Serum dehydroepiandrosterone levels are associated with lower risk of type 2 diabetes: the Rotterdam Study.
Hypertension
Steroid sulfatase inhibitor alters blood pressure and steroid profiles in hypertensive rats.
Hypertension
The epidemiology of DHEAS and cardiovascular disease.
Hypertension
von Willebrand factor, tissue plasminogen activator, and dehydroepiandrosterone sulphate predict cardiovascular death in a 10 year follow up of survivors of acute myocardial infarction.
Hyperthyroidism
Decreased serum IGF-I and dehydroepiandrosterone sulphate may be risk factors for the development of reduced bone mass in postmenopausal women with endogenous subclinical hyperthyroidism.
Hyperthyroidism
Serum concentration of androstenediol and androstenediol sulfate in patients with hyperthyroidism and hypothyroidism.
Hypoglycemia
Cortisol hyporesponsiveness to the low dose ACTH test is a frequent finding in a pediatric population with type 1 diabetes mellitus.
Hypoglycemia
Hypoglycemia and Glucocorticoid-free Immunosuppression are Related With Low Dehydroepiandrosterone Sulfate Level.
Hypoglycemia
Impact of glycemic variations on the regulation of androgen metabolism in obese women with polycystic ovary syndrome.
Hypogonadism
A new syndrome of anosmia, ichthyosis, hypogonadism, and various neurological manifestations with deficiency of steroid sulfatase and arylsulfatase C.
Hypogonadism
Androgen deficiency in women with hypopituitarism.
Hypogonadism
Hypogonadotrophic hypogonadism with hyposmia, X-linked ichthyosis, and renal malformation syndrome.
Hypogonadism
Ichthyosis vulgaris with hypogenitalism and hypogonadism: evidence for different genotypes by lipoprotein electrophoresis and steroid sulfatase testing.
Hypogonadism
Inhibin B, AMH, but not INSL3, IGF1 or DHEAS support differentiation between constitutional delay of growth and puberty and hypogonadotropic hypogonadism.
Hypogonadism
More on X-linked ichthyosis, steroid sulfatase deficiency, and hypogonadism and anosmia.
Hypogonadism
Persistent amenorrhea and decreased DHEAS to cortisol ratio after recovery from anorexia nervosa.
Hypogonadism
Primary hypogonadism in females with infantile onset spinocerebellar ataxia.
Hypogonadism
Steroid sulphatase deficiency and hypogonadism.
Hypogonadism
X-linked ichthyosis due to steroid sulfatase deficiency associated with hypogonadism and anosmia.
Hypogonadism
X-linked ichthyosis with hypogonadism: not always Kallmann's syndrome.
Hypogonadism
X-linked ichthyosis, due to steroid sulphatase deficiency, associated with Kallmann syndrome (hypogonadotropic hypogonadism and anosmia): linkage relationships with Xg and cloned DNA sequences from the distal short arm of the X chromosome.
Hypogonadism
[Hormone therapy in the aging male. Estrogen, DHEA, melatonin, somatotropin]
Hypogonadism
[Steroid sulfatase and placental deficiency. Current data as instigators of new research]
Hypophosphatemia
Mapping of the glycine receptor alpha 2-subunit gene and the GABAA alpha 3-subunit gene on the mouse X chromosome.
Hypothyroidism
Dehydroepiandrostenedione sulphate (DHEAS) levels predict high risk of rheumatoid arthritis (RA) in subclinical hypothyroidism.
Hypothyroidism
Dehydroepiandrosterone-sulfate serum levels and common age-related diseases: results from a cross-sectional Italian study of a general elderly population.
Hypothyroidism
Plasma dehydroepiandrosterone sulphate in hypothyroid premenopausal women.
Hypothyroidism
Serum concentration of androstenediol and androstenediol sulfate in patients with hyperthyroidism and hypothyroidism.
Ichthyosis
A clinical and genetic study of X-linked recessive ichthyosis and contiguous gene defects.
Ichthyosis
A familial X/Y translocation in a boy with ichthyosis, hypogonadism and mental retardation.
Ichthyosis
A family with fragile X syndrome, Duchenne muscular dystrophy and ichthyosis transmitted by an asymptomatic carrier.
Ichthyosis
A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins.
Ichthyosis
A model of corrective gene transfer in X-linked ichthyosis.
Ichthyosis
A new method for the determination of steroid sulphatase activity in leukocytes in X-linked recessive ichthyosis.
Ichthyosis
A new syndrome of anosmia, ichthyosis, hypogonadism, and various neurological manifestations with deficiency of steroid sulfatase and arylsulfatase C.
Ichthyosis
A novel point mutation in the steroid sulfatase gene in X-linked ichthyosis.
Ichthyosis
A study of the steroid sulfatase gene in families with X-linked ichthyosis using polymerase chain reaction.
Ichthyosis
Abnormal androgen and oestrogen metabolism in men with steroid sulphatase deficiency and recessive X-linked ichthyosis.
Ichthyosis
Absence of male-pattern baldness in men with X-linked recessive ichthyosis? A hypothesis to be challenged.
Ichthyosis
Absence of testicular steroid sulphatase activity in a boy with recessive X-linked ichthyosis and testicular maldescent.
Ichthyosis
An update on molecular aspects of the non-syndromic ichthyoses.
Ichthyosis
An Xp22 microdeletion associated with ocular albinism and ichthyosis: approximation of breakpoints and estimation of deletion size by using cloned DNA probes and flow cytometry.
Ichthyosis
Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis.
Ichthyosis
Arylsulfatase C activities in skin preparations of X-linked and autosomal dominant ichthyosis.
Ichthyosis
Assignment by deletion mapping of the steroid sulfatase X-linked ichthyosis locus to Xp223.
Ichthyosis
Atypical X-linked ichthyosis in a patient with a large deletion involving the steroid sulfatase (STS) gene.
Ichthyosis
Autosomal dominant and X-linked ichthyosis in the same family. Biochemical analysis of steroid sulfatase activity.
Ichthyosis
Banding pattern on polarized hair microscopic examination and unilateral polymicrogyria in a patient with steroid sulfatase deficiency.
Ichthyosis
Basis for abnormal desquamation and permeability barrier dysfunction in RXLI.
Ichthyosis
Behavioural and psychiatric phenotypes in female carriers of genetic mutations associated with X-linked ichthyosis.
Ichthyosis
Behavioural and Psychiatric Phenotypes in Men and Boys with X-Linked Ichthyosis: Evidence from a Worldwide Online Survey.
Ichthyosis
Burn injury and wound healing in X-linked ichthyosis.
Ichthyosis
Carrier identification by FISH analysis in isolated cases of X-linked ichthyosis.
Ichthyosis
Carrier identification in steroid sulphatase deficiency and recessive X-linked ichthyosis.
Ichthyosis
Characterization of low-density lipoproteins from patients with recessive X-linked ichthyosis.
Ichthyosis
Characterization of point mutations in patients with X-linked ichthyosis. Effects on the structure and function of the steroid sulfatase protein.
Ichthyosis
Cholesterol sulfotransferase of newborn mouse epidermis.
Ichthyosis
Cholesterol sulphate in the microsomal sulphatase deficient placenta.
Ichthyosis
Clinical features and genetic analysis of two Chinese families with X-linked ichthyosis.
Ichthyosis
Clinical pathologic correlation of superficial corneal opacities in X-linked ichthyosis.
Ichthyosis
Clinical spectrum of steroid sulfatase deficiency: X-linked recessive ichthyosis, birth complications and cryptorchidism.
Ichthyosis
Cloning of a cDNA for steroid sulfatase: frequent occurrence of gene deletions in patients with recessive X chromosome-linked ichthyosis.
Ichthyosis
CO-OCCURRENCE OF PRIMARY MICROCEPHALY CAUSED BY A NOVEL HOMOZYGOUS ASPM MUTATION ALONG WITH X-LINKED ICHTHYOSIS IN THE SAME PATIENT.
Ichthyosis
Commercial assay for steroid sulphatase activity in X-linked ichthyosis.
Ichthyosis
Correction of steroid sulfatase deficiency by gene transfer into basal cells of tissue-cultured epidermis from patients with recessive X-linked ichthyosis.
Ichthyosis
Deficiency of arylsulfatase C in cultured skin fibroblasts of X-linked ichthyosis.
Ichthyosis
Deletion analysis maps ocular albinism proximal to the steroid sulphatase locus.
Ichthyosis
Deletion of a DNA sequence in eight of nine families with X-linked ichthyosis (steroid sulphatase deficiency).
Ichthyosis
Deletion of distal promoter of VCXA in a patient with X-linked ichthyosis associated with borderline mental retardation.
Ichthyosis
Deletion of exons 1-5 of the STS gene causing X-linked ichthyosis.
Ichthyosis
Deletion of the distal short arm of the X chromosome (Xp) in a patient with short stature, chondrodysplasia punctata, and X-linked ichthyosis due to steroid sulfatase deficiency.
Ichthyosis
Deletion pattern of the steroid sulphatase gene in Japanese patients with X-linked ichthyosis.
Ichthyosis
Deletion pattern of the STS gene in X-linked ichthyosis in a Mexican population.
Ichthyosis
Deletion patterns of the STS gene and flanking sequences in Israeli X-linked ichthyosis patients and carriers: analysis by polymerase chain reaction and fluorescence in situ hybridization techniques.
Ichthyosis
Deletions of the steroid sulphatase gene in "classical" X-linked ichthyosis and in X-linked ichthyosis associated with Kallmann syndrome.
Ichthyosis
Detection of carriers for X-linked ichthyosis by Southern blot analysis and identification of one family with a de novo mutation.
Ichthyosis
Detection of heterozygotes of X-linked ichthyosis by measuring steroid sulphatase activity of lymphocytes. Mode of inheritance in three families.
Ichthyosis
Diagnosis of a deletion of steroid sulfatase by polymerase chain reaction and high-performance liquid chromatography.
Ichthyosis
Enzymatic basis of typical X-linked icthyosis.
Ichthyosis
Evidence of the high prevalence of neurological disorders in nonsyndromic X-linked recessive ichthyosis: a retrospective case series.
Ichthyosis
Exacerbation of ichthyosis vulgaris phenotype by co-inheritance of STS and FLG mutations in a Chinese family with ichthyosis: a case report.
Ichthyosis
Exacerbation of X-linked ichthyosis phenotype in a female by inheritance of filaggrin and steroid sulfatase mutations.
Ichthyosis
Failure of steroid sulfatase to desulfate vitamin D3 sulfate.
Ichthyosis
Familial X-linked ichthyosis, steroid sulfatase deficiency, mental retardation, and nullisomy for Xp223-pter.
Ichthyosis
Fine mapping of the distal short arm of the human X chromosome using X/Y translocations.
Ichthyosis
Further evidence for the assignment of the steroid sulfatase X-linked ichthyosis locus to the telomer of Xp.
Ichthyosis
Genetic complementation of steroid sulphatase after somatic cell hybridization of X-linked ichthyosis and multiple sulphatase deficiency.
Ichthyosis
Genetic heterogeneity of steroid sulfatase deficiency revealed with cDNA for human steroid sulfatase.
Ichthyosis
Genetic skin diseases.
Ichthyosis
Hair root analysis in X-linked ichthyosis.
Ichthyosis
High levels of oxysterol sulfates in serum of patients with steroid sulfatase deficiency.
Ichthyosis
Hypogonadotrophic hypogonadism with hyposmia, X-linked ichthyosis, and renal malformation syndrome.
Ichthyosis
Ichthyosis of steroid sulphatase deficiency. Clinical study of 76 cases.
Ichthyosis
Ichthyosis vulgaris with hypogenitalism and hypogonadism: evidence for different genotypes by lipoprotein electrophoresis and steroid sulfatase testing.
Ichthyosis
Ichthyosis. Reliability of clinical signs in the differentiation between autosomal dominant and sex-linked forms.
Ichthyosis
Ichthyosis: etiology, diagnosis, and management.
Ichthyosis
Ichthyosis: the skin manifestation of multiple sulfatase deficiency.
Ichthyosis
Identification of point mutations in the steroid sulfatase gene of three patients with X-linked ichthyosis.
Ichthyosis
In vivo confocal microscopy of pre-Descemet corneal dystrophy associated with X-linked ichthyosis: a case report.
Ichthyosis
Increased cholesterol sulfate in plasma and red blood cell membranes of steroid sulfatase deficient patients.
Ichthyosis
Increased levels of DHEAS in serum of patients with X-linked ichthyosis.
Ichthyosis
Isolation and characterization of a steroid sulfatase cDNA clone: genomic deletions in patients with X-chromosome-linked ichthyosis.
Ichthyosis
Kallmann syndrome and ichthyosis: a case of contiguous gene deletion syndrome.
Ichthyosis
Keratinocyte lipid fluidity under the influence of cholesterols, hydrocortisones, "active lipid", tocopherol and retinoic acid--a fluorescence polarization study with regard to physiological and pathophysiological epidermopoiesis and its therapeutic accessibility.
Ichthyosis
Lipids in the pathogenesis of ichthyosis: topical cholesterol sulfate-induced scaling in hairless mice.
Ichthyosis
Lipoprotein electrophoresis in recessive X-linked ichthyosis.
Ichthyosis
Low estriol levels in the maternal triple-marker screen as a predictor of isolated adrenocorticotropic hormone deficiency caused by a new mutation in the TPIT gene.
Ichthyosis
Low maternal serum unconjugated estriol during prenatal screening as an indication of placental steroid sulfatase deficiency and X-linked ichthyosis.
Ichthyosis
Male-pattern baldness in men with X-linked recessive ichthyosis.
Ichthyosis
Male-pattern baldness is common in men with X-linked recessive ichthyosis.
Ichthyosis
Maternal serum unconjugated estriol as a predictor for Smith-Lemli-Opitz syndrome and other fetal conditions.
Ichthyosis
Measuring scale steroid sulfatase and beta-lipoprotein mobility in ichthyosis.
Ichthyosis
Medical and neurobehavioural phenotypes in carriers of X-linked ichthyosis-associated genetic deletions in the UK Biobank.
Ichthyosis
Metabolism of 3H-dehydroepiandrosterone sulphate by subjects with steroid sulphatase deficiency.
Ichthyosis
Mild ichthyosis in a 4-year-old boy with multiple sulphatase deficiency.
Ichthyosis
Molecular analysis of X-linked ichthyosis in Japan.
Ichthyosis
Molecular heterogeneity of steroid sulfatase deficiency: a multicenter study on 57 unrelated patients, at DNA and protein levels.
Ichthyosis
Molecular studies of deletions at the human steroid sulfatase locus.
Ichthyosis
More on X-linked ichthyosis, steroid sulfatase deficiency, and hypogonadism and anosmia.
Ichthyosis
Most "sporadic" cases of X-linked ichthyosis are not de novo mutations.
Ichthyosis
Mutation report: a novel partial deletion of exons 2-10 of the STS gene in recessive X-linked ichthyosis.
Ichthyosis
Mutations in X-linked ichthyosis disrupt the active site structure of estrone/DHEA sulfatase.
Ichthyosis
Novel filaggrin mutation but no other loss-of-function variants found in ethiopian atopic-dermatitis patients.
Ichthyosis
Novel point mutations in the steroid sulfatase gene in patients with X-linked ichthyosis: transfection analysis using the mutated genes.
Ichthyosis
Oral fluconazole treatment of fungating candidiasis in the keratitis, ichthyosis and deafness (KID) syndrome.
Ichthyosis
Palmoplantar keratoderma with an unusual composition of stratum corneum and serum sterol derivatives: a new entity?
Ichthyosis
Partial lyonisation of steroid sulphatase gene in single hair roots.
Ichthyosis
PCR diagnosis of X-linked ichthyosis: identification of a novel mutation (E560P) of the steroid sulfatase gene.
Ichthyosis
Physical mapping of deletion breakpoints in patients with X-linked ichthyosis: evidence for clustering of distal and proximal breakpoints.
Ichthyosis
Placental steroid sulphatase deficiency.
Ichthyosis
Placental steroid sulphatase deficiency: an approach to antenatal care and delivery.
Ichthyosis
Placental sulfatase deficiency: maternal and fetal expression of steroid sulfatase deficiency and X-linked ichthyosis.
Ichthyosis
Pre-Descemet corneal dystrophy and X-linked ichthyosis associated with deletion of Xp22.31 containing the STS gene.
Ichthyosis
Prenatal detection of X-linked ichthyosis by maternal serum screening for Down syndrome.
Ichthyosis
Prenatal diagnosis of X-linked ichthyosis using molecular cytogenetics.
Ichthyosis
Prenatal diagnosis of X-linked ichthyosis.
Ichthyosis
Prenatal in situ hybridization test for deleted steroid sulfatase gene.
Ichthyosis
Rapid laboratory diagnostic of X-linked ichthyosis.
Ichthyosis
Recessive X-linked ichthyosis: lack of immunologically detectable steroid sulfatase enzyme protein.
Ichthyosis
Recurrent bilateral corneal erosions due to an association of epidermolysis bullosa simplex Köbner and X-linked ichthyosis with steroid sulfatase deficiency.
Ichthyosis
Regional assignment of the gene locus for steroid sulfatase.
Ichthyosis
Renal dysgenesis and KAL1 gene defects in patients with sporadic Kallmann syndrome.
Ichthyosis
Review: genetics of steroid sulphatase deficiency and X-linked ichthyosis.
Ichthyosis
Role of cholesterol sulfate in epidermal structure and function: lessons from X-linked ichthyosis.
Ichthyosis
Role of the pseudoautosomal region in sex-chromosome pairing during male meiosis: meiotic studies in a man with a deletion of distal Xp.
Ichthyosis
Serum steroid sulphates in ichthyosis.
Ichthyosis
Sex-linked ichthyosis and placental sulphatase C deficiency.
Ichthyosis
Somatic and germinal mosaicism for the steroid sulfatase gene deletion in a steroid sulfatase deficiency carrier.
Ichthyosis
Steroid sulfatase = aryl sulfatase C? Chromatographic and electrophoretic properties in extracts from placental microsomes and skin fibroblasts.
Ichthyosis
Steroid sulfatase activity in human leukocytes.
Ichthyosis
Steroid sulfatase activity in nails: screening for X-linked ichthyosis.
Ichthyosis
Steroid sulfatase and filaggrin mutations in a boy with severe ichthyosis, elevated serum IgE level and moyamoya syndrome.
Ichthyosis
Steroid sulfatase deficiency and X-linked ichthyosis.
Ichthyosis
Steroid sulfatase deficiency in Japanese patients: characterization of X-linked ichthyosis by using polymerase chain reaction.
Ichthyosis
Steroid sulfatase of human leukocytes and epidermis and the diagnosis of recessive X-linked ichthyosis.
Ichthyosis
Steroid sulfatase, X-linked ichthyosis, and stratum corneum cell cohesion.
Ichthyosis
Steroid sulfatase. Biosynthesis and processing in normal and mutant fibroblasts.
Ichthyosis
Steroid sulphatase activity in the skin biopsies of various types of ichthyosis.
Ichthyosis
Steroid sulphatase deficiency associated with testis cancer.
Ichthyosis
Steroid sulphatase deficiency disease.
Ichthyosis
Steroid sulphatase deficiency in patients initially diagnosed as ichthyosis vulgaris or recessive X-linked ichthyosis.
Ichthyosis
Steroid sulphatase deficiency: identification of heterozygotes using hydrolysis of dehydroepiandrosterone sulphate by peripheral leucocytes.
Ichthyosis
Steroid sulphatase in man: a non inactivated X-locus with partial gene dosage compensation.
Ichthyosis
Steroid-resistant nephrotic syndrome associated with steroid sulfatase deficiency-x-linked recessive ichthyosis: a case report and review of literature.
Ichthyosis
Stratum corneum lipids in disorders of cornification. Steroid sulfatase and cholesterol sulfate in normal desquamation and the pathogenesis of recessive X-linked ichthyosis.
Ichthyosis
Stratum corneum lipids in disorders of cornification: increased cholesterol sulfate content of stratum corneum in recessive x-linked ichthyosis.
Ichthyosis
Submicroscopic Xpter deletion in a boy with growth and mental retardation caused by a familial t(X;14).
Ichthyosis
Substrate specific sulfatase activity from hair follicles in recessive X-linked ichthyosis.
Ichthyosis
Sulfatase activity of keratinizing tissues in X-linked ichthyosis.
Ichthyosis
Testis cancer. Ichthyosis constitutes a significant risk factor.
Ichthyosis
The biochemical identification of carrier state in mothers of sporadic cases of X-linked recessive ichthyosis.
Ichthyosis
The detection of steroid sulfatase gene deletion (STS) in Egyptian males with X-linked ichthyosis.
Ichthyosis
The effect of steroid sulphatase on stratum corneum shedding in patients with X-linked ichthyosis.
Ichthyosis
The phenotype spectrum of X-linked ichthyosis identified by chromosomal microarray.
Ichthyosis
Two cases of steroid sulfatase deficiency with complex phenotype due to contiguous gene deletions.
Ichthyosis
Updated molecular genetics and pathogenesis of ichthiyoses.
Ichthyosis
X-chromosome inactivation: role in skin disease expression.
Ichthyosis
X-linkage of steroid sulphatase in the mouse is evidence for a functional Y-linked allele.
Ichthyosis
X-linked dominant chondrodysplasia punctata with decreased dihydroxyacetone phosphate acyltransferase activity.
Ichthyosis
X-linked ichthyosis (steroid sulfatase deficiency) is associated with increased risk of attention deficit hyperactivity disorder, autism and social communication deficits.
Ichthyosis
X-linked ichthyosis along with epidermolysis bullosa.
Ichthyosis
X-linked ichthyosis and ichthyosis vulgaris: comparison of their clinical features based on biochemical analysis.
Ichthyosis
X-linked ichthyosis and X-linked placental sulfatase deficiency: a disease entity. Histochemical observations.
Ichthyosis
X-linked ichthyosis associated with psychosis and behavioral abnormalities: a case report.
Ichthyosis
X-linked ichthyosis due to steroid sulfatase deficiency associated with hypogonadism and anosmia.
Ichthyosis
X-linked ichthyosis in Mexico: high frequency of deletions in the steroid sulfatase encoding gene.
Ichthyosis
X-linked ichthyosis with hypogonadism: not always Kallmann's syndrome.
Ichthyosis
X-linked ichthyosis without STS deficiency: clinical, genetical, and molecular studies.
Ichthyosis
X-linked ichthyosis, due to steroid sulphatase deficiency, associated with Kallmann syndrome (hypogonadotropic hypogonadism and anosmia): linkage relationships with Xg and cloned DNA sequences from the distal short arm of the X chromosome.
Ichthyosis
X-linked ichthyosis: a metabolic disease.
Ichthyosis
X-linked ichthyosis: Clinical and molecular findings in 35 Italian patients.
Ichthyosis
X-linked ichthyosis: increased blood cholesterol sulfate and electrophoretic mobility of low-density lipoprotein.
Ichthyosis
X-linked ichthyosis: relation between cholesterol sulphate, dehydroepiandrosterone sulphate and patient's age.
Ichthyosis
X-linked recessive ichthyosis. Enzymatic diagnosis of affected males and female carriers.
Ichthyosis
X-linked recessive ichthyosis. Reinvestigation of a family first described in 1928.
Ichthyosis
X-linked recessive ichthyosis: an impaired barrier function evokes limited gene responses before and after moisturizing treatments.
Ichthyosis
X/Y translocation in a family with X-linked ichthyosis, chondrodysplasia punctata, and mental retardation: DNA analysis reveals deletion of the steroid sulphatase gene and translocation of its Y pseudogene.
Ichthyosis
X?linked ichthyosis and Crigler?Najjar syndrome ?: Coexistence in a male patient with two copy number variable regions of 2q37.1 and Xp22.3.
Ichthyosis
Xp22.3 deletions in isolated familial Kallmann's syndrome.
Ichthyosis
Xp22.3 interstitial deletion: A recognizable chromosomal abnormality encompassing VCX3A and STS genes in a patient with X-linked ichthyosis and mental retardation.
Ichthyosis
[A Case of Steroid Sulfatase Deficiency Complicated by Bilateral Undescended Testis].
Ichthyosis
[Arylsulfatase C deficiency in leukocytes in patients and carrier of X-chromosome recessive ichthyosis]
Ichthyosis
[Biochemical diagnosis of X chromosomal ichthyosis]
Ichthyosis
[Biochemical study on steroid sulfatase and its clinical application to the obstetrics and gynecology]
Ichthyosis
[Functional consequences of cutaneous lipid perturbation]
Ichthyosis
[Hope for new therapies of severe genetic skin diseases]
Ichthyosis
[Ichthyosis and steroid sulfatase: study of enzymatic activity in leukocytes and fibroblasts according to the sex and type of ichthyosis]
Ichthyosis
[Ichthyosis X. Clinical review and rapid identification using lipid electrophoresis]
Ichthyosis
[Identification of gene mutation and prenatal diagnosis in a family with X-linked ichthyosis].
Ichthyosis
[Investigation of steroid sulfatase gene in two pedigrees with X-linked ichthyosis]
Ichthyosis
[Occurrence of X-linked ichthyosis along with atopy]
Ichthyosis
[Progress in dermatology: new biochemical aspects]
Ichthyosis
[The enzyme arylsulfatase C and steroid sulfatase as biochemical markers and pathogenetic factors in X-chromosome recessively inherited ichthyosis]
Ichthyosis
[The genetics and molecular genetics of X-chromosomal recessive ichthyosis]
Ichthyosis
[Two cases of X-linked ichthyosis associated with myopathies]
Ichthyosis
[X-chromosomal recessive ichthyosis. Detection of heterozygote status in genetically possible carriers by determination of arylsulfatase C activity]
Ichthyosis
[X-chromosome-linked ichthyosis associated to epilepsy, hyperactivity, autism and mental retardation, due to the Xp22.31 microdeletion].
Ichthyosis
[X-linked recessive ichthyosis (XRI), cerebellar ataxia and neuropsychiatric symptoms].
Ichthyosis Vulgaris
Elevated levels of arylsulfatase C activity in cultured skin fibroblasts of patients with autosomal dominant ichthyosis vulgaris.
Ichthyosis Vulgaris
Ichthyosis vulgaris with hypogenitalism and hypogonadism: evidence for different genotypes by lipoprotein electrophoresis and steroid sulfatase testing.
Ichthyosis Vulgaris
Steroid sulphatase deficiency in patients initially diagnosed as ichthyosis vulgaris or recessive X-linked ichthyosis.
Ichthyosis Vulgaris
X-linked ichthyosis and ichthyosis vulgaris: comparison of their clinical features based on biochemical analysis.
Ichthyosis, X-Linked
Advances in prenatal screening for Down syndrome: I. general principles and second trimester testing.
Ichthyosis, X-Linked
Are low maternal estriol levels a predictor for pro-opiomelanocortin (POMC) deficiency caused by POMC mutation during pregnancy?
Ichthyosis, X-Linked
Association of undetectable unconjugated estriol on multiple marker screening with steroid sulfatase deficiency.
Ichthyosis, X-Linked
Banding pattern on polarized hair microscopic examination and unilateral polymicrogyria in a patient with steroid sulfatase deficiency.
Ichthyosis, X-Linked
Characterization of a low copy repetitive element S232 involved in the generation of frequent deletions of the distal short arm of the human X chromosome.
Ichthyosis, X-Linked
Characterization of low-density lipoproteins from patients with recessive X-linked ichthyosis.
Ichthyosis, X-Linked
Characterization of the deletion breakpoints in a patient with steroid sulfatase deficiency.
Ichthyosis, X-Linked
Clinical pathologic correlation of superficial corneal opacities in X-linked ichthyosis.
Ichthyosis, X-Linked
Clinical spectrum of steroid sulfatase deficiency: X-linked recessive ichthyosis, birth complications and cryptorchidism.
Ichthyosis, X-Linked
Congenital hypopituitarism as a cause of undetectable estriol levels in the maternal triple-marker screen.
Ichthyosis, X-Linked
Contiguous gene syndromes due to deletions in the distal short arm of the human X chromosome.
Ichthyosis, X-Linked
Correction of steroid sulfatase deficiency by gene transfer into basal cells of tissue-cultured epidermis from patients with recessive X-linked ichthyosis.
Ichthyosis, X-Linked
Deletion of exons 1-5 of the STS gene causing X-linked ichthyosis.
Ichthyosis, X-Linked
Deletion of the distal short arm of the X chromosome (Xp) in a patient with short stature, chondrodysplasia punctata, and X-linked ichthyosis due to steroid sulfatase deficiency.
Ichthyosis, X-Linked
Deletion pattern of the STS gene in X-linked ichthyosis in a Mexican population.
Ichthyosis, X-Linked
Does steroid sulfatase deficiency influence postpartum psychosis risk?
Ichthyosis, X-Linked
Dosage of the Sts gene in the mouse.
Ichthyosis, X-Linked
Enzymatic diagnosis of steroid sulfatase deficiency by high performance liquid chromatography.
Ichthyosis, X-Linked
Familial X-linked ichthyosis, steroid sulfatase deficiency, mental retardation, and nullisomy for Xp223-pter.
Ichthyosis, X-Linked
Frequency of steroid sulfatase deficiency in Hiroshima.
Ichthyosis, X-Linked
Frequent deletions of the human X chromosome distal short arm result from recombination between low copy repetitive elements.
Ichthyosis, X-Linked
Genetic heterogeneity of steroid sulfatase deficiency revealed with cDNA for human steroid sulfatase.
Ichthyosis, X-Linked
High levels of oxysterol sulfates in serum of patients with steroid sulfatase deficiency.
Ichthyosis, X-Linked
Ichthyosis: the skin manifestation of multiple sulfatase deficiency.
Ichthyosis, X-Linked
Increased cholesterol sulfate in plasma and red blood cell membranes of steroid sulfatase deficient patients.
Ichthyosis, X-Linked
Low maternal serum unconjugated estriol during prenatal screening as an indication of placental steroid sulfatase deficiency and X-linked ichthyosis.
Ichthyosis, X-Linked
Low or absent unconjugated estriol in pregnancy: an indicator for steroid sulfatase deficiency detectable by fluorescence in situ hybridization and biochemical analysis.
Ichthyosis, X-Linked
Maternal serum unconjugated estriol as a predictor for Smith-Lemli-Opitz syndrome and other fetal conditions.
Ichthyosis, X-Linked
Maternal steroid sulfatase deficiency--cause of high-risk pregnancy?
Ichthyosis, X-Linked
Maternal transmission of the 3 bp deletion within exon 7 of the STS gene in steroid sulfatase deficiency.
Ichthyosis, X-Linked
Maternal urine and serum steroid measurements to identify steroid sulfatase deficiency (STSD) in second trimester pregnancies.
Ichthyosis, X-Linked
Molecular heterogeneity of steroid sulfatase deficiency: a multicenter study on 57 unrelated patients, at DNA and protein levels.
Ichthyosis, X-Linked
More on X-linked ichthyosis, steroid sulfatase deficiency, and hypogonadism and anosmia.
Ichthyosis, X-Linked
Multipoint linkage analysis of steroid sulfatase (X-linked ichthyosis) and distal Xp markers.
Ichthyosis, X-Linked
Mutation report: a novel partial deletion of exons 2-10 of the STS gene in recessive X-linked ichthyosis.
Ichthyosis, X-Linked
Nonsyndromic types of ichthyoses - an update.
Ichthyosis, X-Linked
Novel point mutations in the steroid sulfatase gene in patients with X-linked ichthyosis: transfection analysis using the mutated genes.
Ichthyosis, X-Linked
Ocular findings in X-linked ichthyosis: a survey on 38 cases.
Ichthyosis, X-Linked
Placental steroid deficiency: association with arylsulfatase A deficiency.
Ichthyosis, X-Linked
Placental steroid sulfatase deficiency.
Ichthyosis, X-Linked
Placental steroid sulfatase deficiency: biochemical diagnosis and clinical review.
Ichthyosis, X-Linked
Placental sulfatase deficiency: maternal and fetal expression of steroid sulfatase deficiency and X-linked ichthyosis.
Ichthyosis, X-Linked
Prenatal diagnosis of placental steroid sulfatase deficiency.
Ichthyosis, X-Linked
Prenatal diagnosis of sex differentiation disorders: the role of fetal ultrasound.
Ichthyosis, X-Linked
Prenatal diagnosis of X-linked ichthyosis using molecular cytogenetics.
Ichthyosis, X-Linked
Prenatal diagnosis of X-linked ichthyosis.
Ichthyosis, X-Linked
Prevalence of steroid sulfatase deficiency in California according to race and ethnicity.
Ichthyosis, X-Linked
Recurrent bilateral corneal erosions due to an association of epidermolysis bullosa simplex Köbner and X-linked ichthyosis with steroid sulfatase deficiency.
Ichthyosis, X-Linked
Regional assignment of the gene locus for steroid sulfatase.
Ichthyosis, X-Linked
Regulation of serum testosterone in men with steroid sulfatase deficiency: response to human chorionic gonadotropin.
Ichthyosis, X-Linked
Role of steroid sulfatase in steroid homeostasis and characterization of the sulfated steroid pathway: Evidence from steroid sulfatase deficiency.
Ichthyosis, X-Linked
Role of the pseudoautosomal region in sex-chromosome pairing during male meiosis: meiotic studies in a man with a deletion of distal Xp.
Ichthyosis, X-Linked
Sequence analysis of a partial deletion of the human steroid sulfatase gene reveals 3 bp of homology at deletion breakpoints.
Ichthyosis, X-Linked
Simultaneous quantification of cholesterol sulfate, androgen sulfates, and progestagen sulfates in human serum by LC-MS/MS.
Ichthyosis, X-Linked
Somatic and germinal mosaicism for the steroid sulfatase gene deletion in a steroid sulfatase deficiency carrier.
Ichthyosis, X-Linked
Steroid sulfatase activity in human leukocytes.
Ichthyosis, X-Linked
Steroid sulfatase activity in leukocytes: a comparative study in 45,X; 46,Xi(Xq) and carriers of steroid sulfatase deficiency.
Ichthyosis, X-Linked
Steroid sulfatase deficiency and contiguous gene deletion syndrome amongst pregnant patients with low serum unconjugated estriols.
Ichthyosis, X-Linked
Steroid sulfatase deficiency and the genetics of the short arm of the human X chromosome.
Ichthyosis, X-Linked
Steroid sulfatase deficiency and X-linked ichthyosis.
Ichthyosis, X-Linked
Steroid sulfatase deficiency in Japanese patients: characterization of X-linked ichthyosis by using polymerase chain reaction.
Ichthyosis, X-Linked
Steroid Sulfatase Deficiency With Bilateral Periventricular Nodular Heterotopia.
Ichthyosis, X-Linked
Steroid sulfatase deficiency.
Ichthyosis, X-Linked
Steroid sulfatase deficiency: enzymatic studies using placenta and leucocytes in one family.
Ichthyosis, X-Linked
Steroid sulfatase-deficient mice exhibit endophenotypes relevant to Attention Deficit Hyperactivity Disorder.
Ichthyosis, X-Linked
Steroid-resistant nephrotic syndrome associated with steroid sulfatase deficiency-x-linked recessive ichthyosis: a case report and review of literature.
Ichthyosis, X-Linked
The human arylsulfatase-C isoenzymes: two distinct genes that escape from X inactivation.
Ichthyosis, X-Linked
Two cases of steroid sulfatase deficiency with complex phenotype due to contiguous gene deletions.
Ichthyosis, X-Linked
Unconjugated estriol as an indication for prenatal diagnosis of steroid sulfatase deficiency by in situ hybridization.
Ichthyosis, X-Linked
Very low maternal serum unconjugated estriol and prenatal diagnosis of steroid sulfatase deficiency.
Ichthyosis, X-Linked
X-linked ichthyosis and X-linked placental sulfatase deficiency: a disease entity. Histochemical observations.
Ichthyosis, X-Linked
X-linked ichthyosis due to steroid sulfatase deficiency associated with hypogonadism and anosmia.
Ichthyosis, X-Linked
X-linked recessive ichthyosis. Enzymatic diagnosis of affected males and female carriers.
Ichthyosis, X-Linked
[A Case of Steroid Sulfatase Deficiency Complicated by Bilateral Undescended Testis].
Ichthyosis, X-Linked
[Biochemical study on steroid sulfatase and its clinical application to the obstetrics and gynecology]
Ichthyosis, X-Linked
[Genetic analysis of a rare case with Kallman syndrome and steroid sulfatase deficiency].
Ichthyosis, X-Linked
[Identification of gene mutation and prenatal diagnosis in a family with X-linked ichthyosis].
Ichthyosis, X-Linked
[Placental steroid sulfatase deficiency. Reduced estriol production]
Ichthyosis, X-Linked
[Steroid sulfatase and placental deficiency. Current data as instigators of new research]
Ichthyosis, X-Linked
[Two cases of X-linked ichthyosis associated with myopathies]
Infections
Cytokine dysregulation and increased oxidation is prevented by dehydroepiandrosterone in mice infected with murine leukemia retrovirus.
Infections
Dehydroepiandrosterone sulphate and androstenedione concentration in the serum of male patients with chronic hepatitis C.
Infections
Higher serum concentrations of DHEAS predict improved nutritional status in helminth-infected children, adolescents, and young adults in Leyte, the Philippines.
Infections
HIV-1 clade C infection and progressive disruption in the relationship between cortisol, DHEAS and CD4 cell numbers: a two-year follow-up study.
Infections
Raised cortisol:DHEAS ratios in the elderly after injury: potential impact upon neutrophil function and immunity.
Infections
The relationships between dehydroepiandrosterone sulphate (DHEAS), the intensity of Schistosoma mansoni infection and parasite-specific antibody responses. A cross-sectional study in residents of endemic communities in north-east Ethiopia.
Infertility
Age related endocrine patterns observed in polycystic ovary syndrome patients vs. ovulatory controls: descriptive data from a university based infertility center.
Infertility
Clomiphene citrate and dexamethazone in treatment of clomiphene citrate-resistant polycystic ovary syndrome: a prospective placebo-controlled study.
Infertility
Peritoneal fluid from patients with unexplained infertility inhibits growth of 2-cell mouse embryos.
Infertility
Plasma homocysteine, fasting insulin, and androgen patterns among women with polycystic ovaries and infertility.
Infertility
Serum levels of DHEAS in gynecologic endocrinopathy and infertility.
Infertility
The effect of dehydroepiandrosterone sulfate prolactin and testosterone hormones in female fertility and hirsutism.
Infertility, Female
The effect of dehydroepiandrosterone sulfate prolactin and testosterone hormones in female fertility and hirsutism.
Infertility, Male
Serum reproductive hormone levels and ultrasound findings in female offspring after intracytoplasmic sperm injection: first results.
Inflammatory Bowel Diseases
Association of humoral markers of inflammation and dehydroepiandrosterone sulfate or cortisol serum levels in patients with chronic inflammatory bowel disease.
Influenza, Human
DHEAS as an effective vaccine adjuvant in elderly humans. Proof-of-principle studies.
Influenza, Human
The development of effective vaccine adjuvants employing natural regulators of T-cell lymphokine production in vivo.
Influenza, Human
The effect of DHEAS on influenza vaccination in aging adults.
Influenza, Human
The use of oral dehydroepiandrosterone sulfate as an adjuvant in tetanus and influenza vaccination of the elderly.
Insulin Resistance
A close association between insulin resistance and dehydroepiandrosterone sulfate in subjects with essential hypertension.
Insulin Resistance
A Twin-Sibling Study on Early Growth and Hormone Levels in Adolescents.
Insulin Resistance
Acute hyperinsulinemia, androgen homeostasis and insulin sensitivity in healthy man.
Insulin Resistance
Androgens and insulin resistance in type 1 diabetic men.
Insulin Resistance
Association of Luteinizing hormone and LH receptor gene polymorphism with susceptibility of Polycystic ovary syndrome.
Insulin Resistance
Body mass index at the presentation of premature adrenarche is associated with components of metabolic syndrome at puberty.
Insulin Resistance
Can metformin reduce insulin resistance in polycystic ovary syndrome?
Insulin Resistance
Chromium supplementation and polycystic ovary syndrome: A systematic review and meta-analysis.
Insulin Resistance
Dehydroepiandrosterone Sulfate (DHEAS) Levels in Polycystic Ovarian Syndrome (PCOS).
Insulin Resistance
Dehydroepiandrosterone sulfate and insulin resistance in patients with polycystic ovary syndrome.
Insulin Resistance
Effect of hyperprolactinemia on the androgen response to an oral glucose load.
Insulin Resistance
Effect of metformin on serum visfatin levels in patients with polycystic ovary syndrome.
Insulin Resistance
Effects of exercise training on plasma androgens in men.
Insulin Resistance
Familial clustering of metabolic phenotype in brothers of women with polycystic ovary syndrome.
Insulin Resistance
Functional correlates of detailed body composition in healthy elderly subjects.
Insulin Resistance
Heterogenous origins of hyperandrogenism in the polycystic ovary syndrome in relation to body mass index and insulin resistance.
Insulin Resistance
Higher steroid sulfation is linked to successful weight loss in obese children.
Insulin Resistance
Hyperinsulinemia and circulating dehydroepiandrosterone sulfate in white and Mexican American women with polycystic ovary syndrome.
Insulin Resistance
In polycystic ovary syndrome, adrenal steroids are regulated differently in the morning versus in response to nutrient intake.
Insulin Resistance
Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist?
Insulin Resistance
Increased plasma thrombin-activatable fibrinolysis inhibitor levels in young obese women with polycystic ovary syndrome.
Insulin Resistance
Is there a relationship between cardiovascular risk factors and dehydroepiandrosterone sulfate levels in childhood obesity?
Insulin Resistance
Low dehydroepiandrosterone sulfate is associated with increased risk of ischemic stroke among women.
Insulin Resistance
MIFEPRISTONE TREATMENT FOR MILD AUTONOMOUS CORTISOL SECRETION DUE TO ADRENAL ADENOMAS: A PILOT STUDY.
Insulin Resistance
Myostatin and its association with abdominal obesity, androgen and follistatin levels in women with polycystic ovary syndrome.
Insulin Resistance
Obesity is the major factor determining an insulin sensitivity and androgen production in women with anovulary cycles.
Insulin Resistance
Opposing effects of dehydroepiandrosterone sulfate and free testosterone on metabolic phenotype in women with polycystic ovary syndrome.
Insulin Resistance
Polycystic ovary syndrome is associated with elevated plasma soluble CD40 ligand, a marker of coronary artery disease.
Insulin Resistance
Recommendations for investigation of hyperandrogenism.
Insulin Resistance
Relation between adiponectin and bone mineral density in elderly post-menopausal women: role of body composition, leptin, insulin resistance, and dehydroepiandrosterone sulfate.
Insulin Resistance
Relationship between the GH/IGF-I axis, insulin sensitivity, and adrenal androgens in normal prepubertal and pubertal boys.
Insulin Resistance
Serum 25-hydroxyvitamin D concentrations in obese and non-obese women with polycystic ovary syndrome.
Insulin Resistance
Serum soluble leptin receptor levels and free leptin index in women with polycystic ovary syndrome: relationship to insulin resistance and androgens.
Insulin Resistance
Serum Zinc and Adiponectin Levels in Patients with Polycystic Ovary Syndrome, Adjusted for Anthropometric, Biochemical, Dietary Intake, and Physical Activity Measures.
Insulin Resistance
Short-term metformin treatment for clomiphene citrate-resistant women with polycystic ovary syndrome.
Insulin Resistance
The association of dehydroepiandrosterone, obesity, waist-hip ratio and insulin resistance with fatty liver in postmenopausal women--a hyperinsulinemic euglycemic insulin clamp study.
Insulin Resistance
The link between metabolic features and TSH levels in polycystic ovary syndrome is modulated by the body weight: an euglycemic-hyperinsulinemic clamp study.
Insulin Resistance
The severity of menstrual dysfunction as a predictor of insulin resistance in PCOS.
Insulin Resistance
The Unique Role of 11-Oxygenated C19 Steroids in Both Premature Adrenarche and Premature Pubarche.
Insulin Resistance
Troglitazone decreases adrenal androgen levels in women with polycystic ovary syndrome.
Insulin Resistance
[A relationship between dehydroepiandrosterone sulphate and insulin resistance in obese men and women]
Intellectual Disability
Analysis of an interstitial deletion in a patient with Kallmann syndrome, X-linked ichthyosis and mental retardation.
Intellectual Disability
Contiguous gene syndromes due to deletions in the distal short arm of the human X chromosome.
Intellectual Disability
Familial X-linked ichthyosis, steroid sulfatase deficiency, mental retardation, and nullisomy for Xp223-pter.
Intellectual Disability
Role of the pseudoautosomal region in sex-chromosome pairing during male meiosis: meiotic studies in a man with a deletion of distal Xp.
Intellectual Disability
Unusual presentation of Kallmannn syndrome with contiguous gene deletion in three siblings of a family.
Intellectual Disability
X/Y translocation in a family with X-linked ichthyosis, chondrodysplasia punctata, and mental retardation: DNA analysis reveals deletion of the steroid sulphatase gene and translocation of its Y pseudogene.
Ischemic Stroke
Low dehydroepiandrosterone sulfate is associated with increased risk of ischemic stroke among women.
Kallmann Syndrome
A yeast artificial chromosome contig linking the steroid sulfatase and Kallmann syndrome loci on the human X chromosome short arm.
Kallmann Syndrome
Contiguous gene syndrome due to deletion of the first three exons of the Kallmann gene and complete deletion of the steroid sulphatase gene.
Kallmann Syndrome
Contiguous gene syndromes due to deletions in the distal short arm of the human X chromosome.
Kallmann Syndrome
Deletion analysis maps ocular albinism proximal to the steroid sulphatase locus.
Kallmann Syndrome
Deletions of the steroid sulphatase gene in "classical" X-linked ichthyosis and in X-linked ichthyosis associated with Kallmann syndrome.
Kallmann Syndrome
Hypogonadotrophic hypogonadism with hyposmia, X-linked ichthyosis, and renal malformation syndrome.
Kallmann Syndrome
Isolation of a new gene GS2 (DXS1283E) from a CpG island between STS and KAL1 on Xp22.3.
Kallmann Syndrome
Kallmann syndrome and ichthyosis: a case of contiguous gene deletion syndrome.
Kallmann Syndrome
Long-range physical mapping around the human steroid sulfatase locus.
Kallmann Syndrome
Long-range restriction map of the terminal part of the short arm of the human X chromosome.
Kallmann Syndrome
Prenatal diagnosis and investigation of a fetus with chondrodysplasia punctata, ichthyosis, and Kallmann syndrome due to an Xp deletion.
Kallmann Syndrome
Unconjugated estriol as an indication for prenatal diagnosis of steroid sulfatase deficiency by in situ hybridization.
Kallmann Syndrome
X-linked ichthyosis, due to steroid sulphatase deficiency, associated with Kallmann syndrome (hypogonadotropic hypogonadism and anosmia): linkage relationships with Xg and cloned DNA sequences from the distal short arm of the X chromosome.
Leiomyoma
Estrone sulfatase activity in human uterine leiomyoma.
Leiomyoma
[Study on the local estrogen biosynthesis in human uterine leiomyoma]
Leukemia, Myeloid, Acute
Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways.
Leukodystrophy, Metachromatic
Enzymic detection of metachromatic leukodystrophy patients and heterozygotes.
Leukodystrophy, Metachromatic
Ichthyosis: the skin manifestation of multiple sulfatase deficiency.
Leukodystrophy, Metachromatic
Juvenile metachromatic leukodystrophy: deficiency of an arylsufatase A component.
Leukodystrophy, Metachromatic
Steroid sulfatase in brain: comparison of sulfohydrolase activities for various steroid sulfates in normal and pathological brains, including the various forms of metachromatic leukodystrophy.
Li-Fraumeni Syndrome
American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach.
Liver Cirrhosis
Dehydroepiandrosterone sulfate and dehydroepiandrosterone sulfate/cortisol ratio in cirrhotic patients with septic shock: another sign of hepatoadrenal syndrome?
Liver Diseases
Inflammatory regulation of steroid sulfatase: A novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease.
Liver Diseases
Reduced brain levels of DHEAS in hepatic coma patients: significance for increased GABAergic tone in hepatic encephalopathy.
Liver Failure
Dehydroepiandrosterone sulphate improves cholestasis-associated fatigue in bile duct ligated rats.
Liver Neoplasms
Expression of 17beta-hydroxysteroid dehydrogenases and other estrogen-metabolizing enzymes in different cancer cell lines.
Lung Diseases
Cardiovascular disease is associated with greater incident dehydroepiandrosterone sulfate decline in the oldest old: the cardiovascular health study all stars study.
Lupus Erythematosus, Systemic
Adrenal androgens and the immune system.
Lupus Erythematosus, Systemic
Blood dehydroepiandrosterone sulphate (DHEAS) levels in polymyalgia rheumatica/giant cell arteritis and primary fibromyalgia.
Lymphopenia
DHEAS and Differential Blood Counts as Indirect Signs of Glucocorticoid Excess in Adrenal Non-Producing Adenomas.
Malnutrition
Higher serum concentrations of DHEAS predict improved nutritional status in helminth-infected children, adolescents, and young adults in Leyte, the Philippines.
Mania
Polymorphisms in AKR1C4 and HSD3B2 and differences in serum DHEAS and progesterone are associated with paranoid ideation during mania or hypomania in bipolar disorder.
Melanoma
Serum dehydroepiandrosterone and dehydroepiandrosterone sulfate and risk of melanoma or squamous cell carcinoma of the skin.
Memory Disorders
DHEAS improves learning and memory in aged SAMP8 mice but not in diabetic mice.
Memory Disorders
Effects of dehydroepiandrosterone and its sulfate on brain tissue in culture and on memory in mice.
Memory Disorders
Effects of sigma(1) receptor agonist SA4503 and neuroactive steroids on performance in a radial arm maze task in rats.
Meningeal Carcinomatosis
Neurosteroids in cerebrospinal fluid in neurologic disorders.
Metabolic Diseases
Characterization of low-density lipoproteins from patients with recessive X-linked ichthyosis.
Metabolic Diseases
[Identification of gene mutation and prenatal diagnosis in a family with X-linked ichthyosis].
Metabolic Syndrome
Cortisol and DHEAS Related to Metabolic Syndrome in Patients with Schizophrenia.
Metabolic Syndrome
Cortisol, DHEAS, their ratio and the metabolic syndrome: evidence from the Vietnam Experience Study.
Metabolic Syndrome
Dehydroepiandrosterone (DHEA) treatment in vitro inhibits adipogenesis in human omental but not subcutaneous adipose tissue.
Metabolic Syndrome
The role of genetic variation in the Lamin A/C gene in the etiology of Polycystic Ovary Syndrome.
Metabolic Syndrome
[Could serum DHEA and DHEAS levels be good risk predictors of metabolic syndrome and osteoporosis in the population of ageing men?]
Metabolic Syndrome
[ROLE OF CAPSAICIN-SENSITIVE NERVES IN THE REGULATION OF DEHYDROEPIANDROSTERONE SULFATE BLOOD CONTENT UNDER NORMAL AND FRUCTOSE-INDUCED METABOLIC SYNDROME].
Metabolism, Inborn Errors
Molecular studies of deletions at the human steroid sulfatase locus.
Migraine Disorders
Sugar alters the level of serum insulin and plasma glucose and the serum cortisol:DHEAS ratio in female migraine sufferers.
Moyamoya Disease
Steroid sulfatase and filaggrin mutations in a boy with severe ichthyosis, elevated serum IgE level and moyamoya syndrome.
Mucocele
Investigation of adrenal and thyroid gland dysfunction in dogs with ultrasonographic diagnosis of gallbladder mucocele formation.
Multiple Endocrine Neoplasia
American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach.
Multiple Endocrine Neoplasia Type 1
American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach.
Multiple Sulfatase Deficiency Disease
Arylsulfatases A and B in EBV-transformed lymphoid cell lines: studies on their molecular forms in cells from patients with inborn sulfatase deficiencies. Comparative diagnostic value of enzymatic assays.
Multiple Sulfatase Deficiency Disease
Ichthyosis: the skin manifestation of multiple sulfatase deficiency.
Multiple Sulfatase Deficiency Disease
Rapid degradation of steroid sulfatase in multiple sulfatase deficiency.
Multiple Sulfatase Deficiency Disease
Synthesis and stability of steroid sulfatase in fibroblasts from multiple sulfatase deficiency.
Murine Acquired Immunodeficiency Syndrome
Immune dysfunction during alcohol consumption and murine AIDS: the protective role of dehydroepiandrosterone sulfate.
Muscle Weakness
The effect of dehydroepiandrosterone sulfate (DHEAS) on myotonia: intracellular studies.
Muscular Dystrophies
A family with fragile X syndrome, Duchenne muscular dystrophy and ichthyosis transmitted by an asymptomatic carrier.
Muscular Dystrophy, Duchenne
Frequent deletions of the human X chromosome distal short arm result from recombination between low copy repetitive elements.
Myocardial Infarction
Dehydroepiandrosterone sulfate and the risk of myocardial infarction in US male physicians: a prospective study.
Myocardial Infarction
Dehydroepiandrosterone sulfate, incidence of myocardial infarction, and extent of atherosclerosis in men.
Myocardial Infarction
Dehydroepiandrosterone, dehydroepiandrosterone sulphate and cardiovascular disease.
Myocardial Infarction
von Willebrand factor, tissue plasminogen activator, and dehydroepiandrosterone sulphate predict cardiovascular death in a 10 year follow up of survivors of acute myocardial infarction.
Myocardial Ischemia
A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease.
Myocardial Ischemia
Dehydroepiandrosterone sulfate does not predict cardiovascular death in postmenopausal women. The Rancho Bernardo Study.
Myocardial Ischemia
The epidemiology of DHEAS and cardiovascular disease.
Myotonia
A pilot study of dehydroepiandrosterone sulfate in myotonic dystrophy.
Myotonia
The effect of dehydroepiandrosterone sulfate (DHEAS) on myotonia: intracellular studies.
Myotonic Dystrophy
The effect of dehydroepiandrosterone sulfate (DHEAS) on myotonia: intracellular studies.
Neoplasm Metastasis
Arylsulfatase B regulates colonic epithelial cell migration by effects on MMP9 expression and RhoA activation.
Neoplasm Metastasis
Asymptomatic adrenal tumours: criteria for endoscopic removal.
Neoplasm Metastasis
Dehydroepiandrosterone sulfate (DHEAS) secretion in early and advanced solid neoplasms: selective deficiency in metastatic disease.
Neoplasm, Residual
Hormonal factors and prognosis in epithelial ovarian cancer: a multivariate analysis.
Neoplasms
17?-Arylsulfonamides of 17?-aminoestra-1,3,5(10)-trien-3-ol as highly potent inhibitors of steroid sulfatase.
Neoplasms
2-Alkylsulfanyl estrogen derivatives: synthesis of a novel class of multi-targeted anti-tumour agents.
Neoplasms
3,17-disubstituted 2-alkylestra-1,3,5(10)-trien-3-ol derivatives: synthesis, in vitro and in vivo anticancer activity.
Neoplasms
A new series of aryl sulfamate derivatives: Design, synthesis, and biological evaluation.
Neoplasms
Achieving the ratiometric imaging of steroid sulfatase in living cells and tissues with a two-photon fluorescent probe.
Neoplasms
Adrenal and sex steroid hormone production by a virilizing adrenal adenoma and its diagnosis with computerized tomography.
Neoplasms
American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach.
Neoplasms
Anti-breast cancer potential of natural and synthetic coumarin derivatives.
Neoplasms
Anti-cancer activities of novel D-ring modified 2-substituted estrogen-3-O-sulfamates.
Neoplasms
ANXA7 expression represents hormone-relevant tumor suppression in different cancers.
Neoplasms
Aromatase and intracrinology of estrogen in hormone-dependent tumors.
Neoplasms
Aromatase inhibitors and other novel agents in breast cancer treatment.
Neoplasms
Bacterial Lipopolysaccharides Induce Steroid Sulfatase Expression and Cell Migration through IL-6 Pathway in Human Prostate Cancer Cells.
Neoplasms
Breast cancer size in postmenopausal women is correlated with body mass index and androgen serum levels.
Neoplasms
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.
Neoplasms
Cortisol, DHEA sulphate, their ratio, and all-cause and cause-specific mortality in the Vietnam Experience Study.
Neoplasms
Decreased levels of dehydroepiandrosterone sulphate in severe critical illness: a sign of exhausted adrenal reserve?
Neoplasms
Decreased serum level of dehydroepiandrosterone sulfate in postmenopausal women with ovarian cancer.
Neoplasms
Defect of a subpopulation of natural killer immune cells in Graves' disease and Hashimoto's thyroiditis: normalizing effect of dehydroepiandrosterone sulfate.
Neoplasms
Dehydroepiandrosterone concentration in breast cancer tissue is related to its plasma gradient across the mammary gland.
Neoplasms
Dehydroepiandrosterone sulfate (DHEAS) and testosterone: relation to HIV illness stage and progression over one year.
Neoplasms
Dehydroepiandrosterone sulfate (DHEAS) secretion in early and advanced solid neoplasms: selective deficiency in metastatic disease.
Neoplasms
Dehydroepiandrosterone sulfate, diseases and mortality in a general aged population.
Neoplasms
Dehydroepiandrosterone sulfate, incidence of myocardial infarction, and extent of atherosclerosis in men.
Neoplasms
Dehydroepiandrosterone-sulfate serum levels and common age-related diseases: results from a cross-sectional Italian study of a general elderly population.
Neoplasms
Design and synthesis of carbon-11-labeled dual aromatase-steroid sulfatase inhibitors as new potential PET agents for imaging of aromatase and steroid sulfatase expression in breast cancer.
Neoplasms
Detection of a novel, primate-specific 'kill switch' tumor suppression mechanism that may fundamentally control cancer risk in humans: an unexpected twist in the basic biology of TP53.
Neoplasms
Detection of a novel, primate-specific kill switch tumor suppression mechanism that may fundamentally control cancer risk in humans: an unexpected twist in the basic biology of TP53
Neoplasms
Detection of breast cancer-associated estrone sulfatase in breast cancer biopsies and cell lines using polymerase chain reaction.
Neoplasms
Development of (p-O-sulfamoyl)-N-alkanoyl-phenylalkyl amines as non-steroidal estrone sulfatase inhibitors.
Neoplasms
Development of novel steroid sulfatase inhibitors; II. TZS-8478 potently inhibits the growth of breast tumors in postmenopausal breast cancer model rats.
Neoplasms
Development of potent non-estrogenic estrone sulfatase inhibitors.
Neoplasms
Development of steroid sulfatase inhibitors.
Neoplasms
DHEAS for the prediction of subclinical Cushing's syndrome: perplexing or advantageous?
Neoplasms
DHEAS levels and mortality in disabled older women: the Women's Health and Aging Study I.
Neoplasms
Dietary intervention at middle age: caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice.
Neoplasms
Differential effect of carbamazepine and valproate monotherapy on plasma levels of oestrone sulphate and dehydroepiandrosterone sulphate in male epileptic patients.
Neoplasms
Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health.
Neoplasms
During a corticotropin-releasing hormone test in healthy subjects, administration of a beta-adrenergic antagonist induced secretion of cortisol and dehydroepiandrosterone sulfate and inhibited secretion of ACTH.
Neoplasms
Early development of osteoporosis in male smokers with hypoandrogenism due to fascioliasis with or without schistosomiasis added by life style.
Neoplasms
Early shifts of adrenal steroid synthesis before and after relief of short-term cholestasis.
Neoplasms
Elevated steroid sulfatase expression in breast cancers.
Neoplasms
Estrogen inhibits cell proliferation through in situ production in human thymoma.
Neoplasms
Estrogen-metabolizing enzymes in breast cancers from women over the age of 80 years.
Neoplasms
Estrogenicity, antiestrogenicity and estrone sulfatase inhibition of estrone-3-amine and estrone-3-thiol.
Neoplasms
Estrone sulfatase activity in normal and abnormal endometrium.
Neoplasms
Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT (SLC10A6).
Neoplasms
Evaluation of cytotoxic effects of several novel tetralin derivatives against Hela, MDA-MB-468, and MCF-7 cancer cells.
Neoplasms
Evidence of in situ estrogen synthesis in nitrosomethylurea-induced rat mammary tumors via the enzyme estrone sulfatase.
Neoplasms
Expression level of enzymes related to in situ estrogen synthesis and clinicopathological parameters in breast cancer patients.
Neoplasms
Expression of sulfotransferases and sulfatases in human breast cancer: Impact on resveratrol metabolism.
Neoplasms
First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors.
Neoplasms
First dual aromatase-steroid sulfatase inhibitors.
Neoplasms
From adrenarche to aging of adrenal zona reticularis: precocious female adrenopause onset.
Neoplasms
Girls with virilisation in childhood: a diagnostic protocol for investigation.
Neoplasms
Human granulosa cells are a site of sulphatase activity and are able to utilize dehydroepiandrosterone sulphate as a precursor for oestradiol production.
Neoplasms
Human steroid sulfatase enhances aerobic glycolysis through induction of HIF1? and glycolytic enzymes.
Neoplasms
Hyperandrogenism and Adrenocortical Tumors.
Neoplasms
Immunohistochemical analysis of estrone sulfatase and aromatase in human breast cancer tissues.
Neoplasms
Immunohistochemical analysis of steroid sulfatase in human tissues.
Neoplasms
Importance of Dehydroepiandrosterone Sulfate Assessment with Special Attention for Adrenal Tumours and Arterial Hypertension.
Neoplasms
In breast cancer subtypes steroid sulfatase (STS) is associated with less aggressive tumour characteristics.
Neoplasms
In situ steroid sulfatase activity in human epithelial carcinoma cells of vaginal, ovarian, and endometrial origin.
Neoplasms
In vitro evaluation of the interaction potential of irosustat with drug-metabolizing enzymes.
Neoplasms
In vitro interactions between mammary fibroblasts (Hs 578Bst) and cancer epithelial cells (MCF-7) modulate aromatase, steroid sulfatase and 17?-hydroxysteroid dehydrogenases.
Neoplasms
In Vitro Metabolism of Irosustat, a Novel Steroid Sulphatase Inhibitor: Inter-Species Comparison, Metabolite Identification and Metabolic Enzyme Identification.
Neoplasms
In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE.
Neoplasms
Increased DHEAS levels in patients with rheumatoid arthritis after treatment with tumor necrosis factor antagonists: evidence for improved adrenal function.
Neoplasms
Increased serum cortisol levels are associated with high tumour grade in patients with renal cell carcinoma.
Neoplasms
Induction of steroid sulfatase expression by tumor necrosis factor-? through phosphatidylinositol 3-kinase/Akt signaling pathway in PC-3 human prostate cancer cells.
Neoplasms
Influence of estrogen metabolism on proliferation of human breast cancer.
Neoplasms
Inhibition of estrone sulfatase activity by estrone-3-methylthiophosphonate: a potential therapeutic agent in breast cancer.
Neoplasms
Inhibition of estrone sulfatase and proliferation of human breast cancer cells by nonsteroidal (p-O-sulfamoyl)-N-alkanoyl tyramines.
Neoplasms
Inhibition of placental estrone sulfatase activity and MCF-7 breast cancer cell proliferation by estrone-3-amino derivatives.
Neoplasms
Inhibition of steroid sulphatase activity by steroidal methylthiophosphonates: potential therapeutic agents in breast cancer.
Neoplasms
Isolated dehydroepiandrosterone sulphate hypersecretion: a case report.
Neoplasms
Localization of Estrone Sulfatase in Human Breast Carcinomas.
Neoplasms
Marked hyperandrogenicity in a 60-year-old woman.
Neoplasms
Measurement of serum levels of dehydroepiandrosterone sulfate: a comparison of radioimmunoassay and enzymatic analysis.
Neoplasms
Microtiter plate cellular assay for human steroid sulfatase with fluorescence readout.
Neoplasms
Oncological markers CA-125, CA 19-9 and endometriosis.
Neoplasms
Peripheral and ovarian venous concentrations of steroid and gonadotropin hormones in postmenopausal women with epithelial ovarian tumors.
Neoplasms
Pharmacokinetics of the nonsteroidal steroid sulphatase inhibitor 667 COUMATE and its sequestration into red blood cells in rats.
Neoplasms
Plasma dehydroepiandrosterone sulfate levels in patients with hyperfunctioning and non-hyperfunctioning adrenal tumors before and after adrenal surgery.
Neoplasms
Predicting malignancy in adrenal incidentaloma and evaluation of a novel risk stratification algorithm.
Neoplasms
Preneoplastic lesions and prognostic factors of breast cancer.
Neoplasms
Prognostic significance of aromatase and estrone sulfatase enzymes in human breast cancer.
Neoplasms
Quantitative analysis of aromatase, sulfatase and 17beta-HSD(1) mRNA expression in soft tissue metastases of breast cancer.
Neoplasms
Recommendations for investigation of hyperandrogenism.
Neoplasms
Reduced expression of steroid sulfatase in primary colorectal cancer.
Neoplasms
Regulation of macrophage dehydroepiandrosterone sulfate metabolism by inflammatory cytokines.
Neoplasms
Relation of Serum Levels of Estrogen and Dehydroepiandrosterone Sulfate to Hormone Receptor Status among Postmenopausal Women with Breast Cancer.
Neoplasms
Role of OATP transporters in steroid uptake by prostate cancer cells in vivo.
Neoplasms
Significance of Steroid Sulfatase Expression in Human Breast Cancer.
Neoplasms
Simultaneous expression of steroid sulfatase and androgen receptor reduced overall survival of patients with epithelial ovarian tumors.
Neoplasms
Simultaneous robotic-assisted adrenalectomy and partial nephrectomy: technical aspects.
Neoplasms
Statin Use at the Time of Initiation of Androgen Deprivation Therapy and Time to Progression in Patients With Hormone-Sensitive Prostate Cancer.
Neoplasms
Steroid hormones and human breast cancer. An hypothesis.
Neoplasms
Steroid sulfatase and estrogen sulfotransferase in human prostate cancer.
Neoplasms
Steroid sulfatase inhibition success and limitation in breast cancer clinical assays: An underlying mechanism.
Neoplasms
Steroid sulfatase inhibitors for estrogen- and androgen-dependent cancers.
Neoplasms
Steroid sulfatase: a new target for the endocrine therapy of breast cancer.
Neoplasms
Strategic approach of hyperandrogenism in women.
Neoplasms
Structure-activity relationship for the first-in-class clinical steroid sulfatase inhibitor Irosustat (STX64, BN83495).
Neoplasms
Structures of human carbonic anhydrase II/inhibitor complexes reveal a second binding site for steroidal and nonsteroidal inhibitors.
Neoplasms
Study of glucose tolerance in consecutive patients harbouring incidental adrenal tumours. Study Group of Incidental Adrenal Adenoma.
Neoplasms
Sulfatase Activity in Normal and Neoplastic Endometrium.
Neoplasms
Sulfatase inhibitors for recidivist breast cancer treatment: A chemical review.
Neoplasms
Sulfate derivatives of 2-phenylindoles as novel steroid sulfataseinhibitors. An in vitro study on structure-activity-relationship.
Neoplasms
Synthesis and biological evaluation of N-acylated tyramine sulfamates containing C-F bonds as steroid sulfatase inhibitors.
Neoplasms
Synthesis and sulfatase inhibitory activities of non-steroidal estrone sulfatase inhibitors.
Neoplasms
Synthesis of 2-[11C]methoxy-3,17?-O,O-bis(sulfamoyl)estradiol as a new potential PET agent for imaging of steroid sulfatase (STS) in cancers.
Neoplasms
Synthesis of a non-hydrolyzable estrone sulfate analogue bearing the difluoromethanesulfonamide group and its evaluation as a steroid sulfatase inhibitor.
Neoplasms
The adrenal steroid status in relation to inflammatory cytokines (interleukin-6 and tumour necrosis factor) in polymyalgia rheumatica.
Neoplasms
The development of steroid sulfatase inhibitors for hormone-dependent cancer therapy.
Neoplasms
The hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate by MCF-7 human breast cancer cells.
Neoplasms
THE RARE CASE OF MIXED GONADAL DYSGENESIS, MOSAIC KARYOTYPE, PETROCLIVAL MENINGIOMA AND IDIOPATHIC HYPERDEHYDROEPIANDROSTERONISM.
Neoplasms
The role of cytokines and sulphatase inhibitors in regulating oestrogen synthesis in breast tumours.
Neoplasms
The sulfatase pathway for estrogen formation: targets for the treatment and diagnosis of hormone-associated tumors.
Neoplasms
The treatment of a hyperandrogenic and virilizing state in an elderly female with a synthetic LHRH agonist.
Neoplasms
The use of steroid sulfatase inhibitors as a novel therapeutic strategy against hormone-dependent endometrial cancer.
Neoplasms
Total testosterone and DHEAS levels as predictors of androgen-secreting neoplasms: a populational study.
Neoplasms
Unusual Visualization of an Adrenal Carcinoma on NP-59 Scintiscan.
Neoplasms
Using molecular docking to investigate the anti-breast cancer activity of low molecular weight compounds present on wild mushrooms.
Neoplasms
V89L polymorphism of the 5alpha-reductase Type II gene (SRD5A2), endogenous sex hormones, and prostate cancer risk.
Neoplasms
Very High Dehydroepiandrosterone Sulfate (DHEAS) in Serum of an Overweight Female Adolescent Without a Tumor.
Neoplasms
[Hyperandrogenism in premenopausal women]
Neoplasms
[Molecular mechanisms of DHEA and DHEAs on apoptosis and cell cycle arrest via Akt pathway in hepatoma cell lines]
Neoplasms
[Replacement therapy in adrenopause. Dehydroepiandrosterone and aging]
Neoplasms
[Sertoli-Leydig cell tumour (arrhenoblastoma) in a patient with polycystic ovary syndrome: clinical, ultrasonographic, hormonal and histopathological evaluation]
Neoplasms
[Tissue culture and estrogen, to clarify the roles of estrone sulfate]
Nephrotic Syndrome
Steroid-resistant nephrotic syndrome associated with steroid sulfatase deficiency-x-linked recessive ichthyosis: a case report and review of literature.
Nervous System Diseases
Physiological implications of DHEAS-induced non-classical steroid hormone signaling.
Nervous System Diseases
The effect of dehydroepiandrosterone sulfate administration to patients with multi-infarct dementia.
Neural Tube Defects
Second-trimester maternal serum screening using alpha-fetoprotein, human chorionic gonadotrophin, and unconjugated oestriol: experience of a regional programme.
Neuralgia
Spinal Nitric Oxide Synthase Type II Increases Neurosteroid-metabolizing Cytochrome P450c17 Expression in a Rodent Model of Neuropathic Pain.
Neuroblastoma
Effect of dehydroepiandrosterone and its sulfate metabolite on neuronal cell viability in culture.
Neuroblastoma
Expression of the neuron-specific protein, 14-3-2, and steroid sulfatase in neuroblastoma cell hybrids.
Neurodegenerative Diseases
Actions of dehydroepiandrosterone and its sulfate in the central nervous system: effects on cognition and emotion in animals and humans.
Neurodegenerative Diseases
Astrocyte Neuroprotection and Dehydroepiandrosterone.
Neurodegenerative Diseases
Preclinical development of neurosteroids as neuroprotective agents for the treatment of neurodegenerative diseases.
Neurodegenerative Diseases
Studies on homocysteine and dehydroepiandrosterone sulphate plasma levels in Alzheimer's disease patients and in Parkinson's disease patients.
Neuroinflammatory Diseases
Neuroprotective Effects of Dehydroepiandrosterone Sulfate Through Inhibiting Expression of Matrix Metalloproteinase-9 from Bradykinin-Challenged Astroglia.
Neurologic Manifestations
A new syndrome of anosmia, ichthyosis, hypogonadism, and various neurological manifestations with deficiency of steroid sulfatase and arylsulfatase C.
Non-alcoholic Fatty Liver Disease
Endocrine factors associated with non-alcoholic fatty liver disease in women with polycystic ovary syndrome: Do androgens play a role?
Non-alcoholic Fatty Liver Disease
Serum dehydroepiandrosterone sulphate levels in patients with non-alcoholic Fatty liver disease.
Obesity
A prospective study of dehydroepiandrosterone sulfate (DHEAS) and bone mineral density in older men and women.
Obesity
A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease.
Obesity
A study of insulin resistance in subjects with acanthosis nigricans.
Obesity
Age-related decline in salivary dehydroepiandrosterone sulfate and associated health risks among African Americans.
Obesity
Dehydroepiandrosterone reduces proliferation and differentiation of 3T3-L1 preadipocytes.
Obesity
Dehydroepiandrosterone sulfate does not predict cardiovascular death in postmenopausal women. The Rancho Bernardo Study.
Obesity
Dehydroepiandrosterone, dehydroepiandrosterone sulfate, obesity, waist-hip ratio, and noninsulin-dependent diabetes in postmenopausal women: the Rancho Bernardo Study.
Obesity
Differential Effects of Various Androgens on Polycystic Ovary Syndrome.
Obesity
GG-genotype in the promotor region of uncoupling-protein-1 gene is associated with lower level of dehydroepiandrosterone in type 2 diabetes.
Obesity
Hepatic Overexpression of Steroid Sulfatase Ameliorates Mouse Models of Obesity and Type 2 Diabetes through Sex-specific Mechanisms.
Obesity
In polycystic ovary syndrome, adrenal steroids are regulated differently in the morning versus in response to nutrient intake.
Obesity
Low dehydroepiandrosterone and ischemic heart disease in middle-aged men: prospective results from the Massachusetts Male Aging Study.
Obesity
Low dehydroepiandrosterone sulfate and heart disease in middle-aged men: cross-sectional results from the Massachusetts Male Aging Study.
Obesity
No acute effect of physiological insulin increase on dehydroepiandrosterone sulfate in women with obesity and/or polycystic ovarian disease.
Obesity
Obesity affects circulating estradiol levels of premenopausal hirsute women receiving leuprolide acetate depot.
Obesity
Predictors of sex hormone levels among the elderly: a study in Greece.
Obesity
The association between dehydroepiandosterone and frailty in older men and women.
Obesity
The association of dehydroepiandrosterone, obesity, waist-hip ratio and insulin resistance with fatty liver in postmenopausal women--a hyperinsulinemic euglycemic insulin clamp study.
Obesity
The independent effects of polycystic ovary syndrome and obesity on serum concentrations of gonadotrophins and sex steroids in premenopausal women.
Obesity
[The influence of obesity on sexual development in pubertal children]
Obesity
[The relationship between serum dehydroepiandrosterone sulfate levels and factors associated with cardiovascular diseases: a cross-sectional study in Japan]
Obesity, Abdominal
Allostatic Load as a Biological Substrate to Intrinsic Capacity: A Secondary Analysis of CRELES.
Obesity, Abdominal
Dehydroepiandrosterone sulfate and testosterone are independently associated with body fat distribution in premenopausal women.
Obesity, Abdominal
Dehydroepiandrosterone, dehydroepiandrosterone sulfate, obesity, waist-hip ratio, and noninsulin-dependent diabetes in postmenopausal women: the Rancho Bernardo Study.
Obesity, Abdominal
Myostatin and its association with abdominal obesity, androgen and follistatin levels in women with polycystic ovary syndrome.
Obesity, Morbid
Role of dehydroepiandrosterone sulfate levels on body composition after laparoscopic adjustable gastric banding in pre-menopausal morbidly obese women.
Obesity, Morbid
Serum concentrations of dehydroepiandrosterone sulfate and leptin in obese patients with normal serum cholesterol.
Opportunistic Infections
Dehydroepiandrosterone sulfate (DHEAS) and testosterone: relation to HIV illness stage and progression over one year.
Osteoarthritis
Blood dehydroepiandrosterone sulphate (DHEAS) levels in pemphigoid/pemphigus and psoriasis.
Osteoarthritis
Blood dehydroepiandrosterone sulphate (DHEAS) levels in polymyalgia rheumatica/giant cell arteritis and primary fibromyalgia.
Osteoarthritis
Relationship between blood and joint tissue DHEAS levels in rheumatoid arthritis and osteoarthritis.
Osteoporosis
A prospective study of dehydroepiandrosterone sulfate (DHEAS) and bone mineral density in older men and women.
Osteoporosis
Carnitine and dehydroepiandrosterone sulfate induce protein synthesis in porcine primary osteoblast-like cells.
Osteoporosis
CYP3A7*1C polymorphism, serum dehydroepiandrosterone sulfate level, and bone mineral density in postmenopausal women.
Osteoporosis
Dehydroepiandrosterone and Bone.
Osteoporosis
Dehydroepiandrosterone-sulfate serum levels and common age-related diseases: results from a cross-sectional Italian study of a general elderly population.
Osteoporosis
Effects of age on serum dehydroepiandrosterone sulfate, IGF-I, and IL-6 levels in women.
Osteoporosis
Replacement therapy with DHEA plus corticosteroids in patients with chronic inflammatory diseases--substitutes of adrenal and sex hormones.
Osteoporosis
Serum dehydroepiandrosterone sulfate, testosterone, and biochemical markers of bone turnover in elderly Thai men.
Osteoporosis
Sex hormone status and osteoporosis in postmenopausal women with rheumatoid arthritis.
Osteoporosis
Sex hormones and quantitative ultrasound parameters at the heel in men and women from the general population.
Osteoporosis
Treatment of osteoporosis in men using dehydroepiandrosterone sulfate.
Osteoporosis
[Could serum DHEA and DHEAS levels be good risk predictors of metabolic syndrome and osteoporosis in the population of ageing men?]
Osteoporosis
[Dehydroepiandrosterone (DHEA)--slows down the aging process?]
Osteoporosis
[Reduced serum dehydroepiandrosterone levels in postmenopausal osteoporosis]
Osteoporosis
[Replacement therapy in adrenopause. Dehydroepiandrosterone and aging]
Ovarian Neoplasms
Circulating levels of sex steroid hormones and risk of ovarian cancer.
Ovarian Neoplasms
Decreased serum level of dehydroepiandrosterone sulfate in postmenopausal women with ovarian cancer.
Ovarian Neoplasms
Estrone sulfatase activity in patients with advanced ovarian cancer.
Ovarian Neoplasms
Peripheral and ovarian venous concentrations of steroid and gonadotropin hormones in postmenopausal women with epithelial ovarian tumors.
Overweight
From adrenarche to aging of adrenal zona reticularis: precocious female adrenopause onset.
Overweight
Hyperandrogenemia in women with polycystic ovary syndrome: prevalence, characteristics and association with body mass index.
Overweight
Maternal Pre-pregnancy BMI and Reproductive Health of Daughters in Young Adulthood.
Overweight
Plasma lipids, dehydroepiandosterone sulphate and insulin concentrations in elderly overweight angina patients, and effect of weight loss.
Overweight
The epidemiology of DHEAS and cardiovascular disease.
Overweight
Trajectories of Growth and Serum DHEAS and IGF-1 Concentrations in Girls With a History of Premature Adrenarche: Attenuation of the Phenotype by Adulthood.
Overweight
Very High Dehydroepiandrosterone Sulfate (DHEAS) in Serum of an Overweight Female Adolescent Without a Tumor.
Pancreatic Neoplasms
Dehydroepiandrosterone modulates oxidative DNA damage in pancreatic cancer: A case-control study.
Paralysis
DHEAS as an effective vaccine adjuvant in elderly humans. Proof-of-principle studies.
Parasitemia
Human resistance to Plasmodium falciparum increases during puberty and is predicted by dehydroepiandrosterone sulfate levels.
Parkinsonian Disorders
Dehydroepiandrosterone-sulfate serum levels and common age-related diseases: results from a cross-sectional Italian study of a general elderly population.
Pemphigus
Evaluating serum prolactin and serum dehydroepiandrosterone sulfate levels in patients with pemphigus.
Periodontitis
Association of cortisol and dehydroepiandrosterone sulphate levels in serum with periodontal status in older Japanese adults.
Periventricular Nodular Heterotopia
Steroid Sulfatase Deficiency With Bilateral Periventricular Nodular Heterotopia.
Pheochromocytoma
Dehydroepiandrosterone and allopregnanolone protect sympathoadrenal medulla cells against apoptosis via antiapoptotic Bcl-2 proteins.
Pheochromocytoma
Laparoscopic adrenalectomy. The importance of a flank approach in the lateral decubitus position.
Pituitary ACTH Hypersecretion
Cushing's syndrome: new variants and association with empty sella syndrome.
Pituitary ACTH Hypersecretion
Dissociation of adrenal androgen and cortisol secretion in Cushing's syndrome.
Pituitary ACTH Hypersecretion
Prostate-specific antigen is increased in female patients with Cushing's disease.
Pituitary ACTH Hypersecretion
Reduced serum levels of dehydroepiandrosterone sulphate in adrenal incidentalomas: a marker of adrenocortical tumour.
Pityriasis
Pityriasis rotunda with low levels of steroid sulfatase.
Polycystic Ovary Syndrome
AMH MEASUREMENT VERSUS OVARIAN ULTRASOUND IN THE DIAGNOSIS OF POLYCYSTIC OVARY SYNDROME IN DIFFERENT PHENOTYPES.
Polycystic Ovary Syndrome
Association of Luteinizing hormone and LH receptor gene polymorphism with susceptibility of Polycystic ovary syndrome.
Polycystic Ovary Syndrome
Dehydroepiandrosterone Sulfate (DHEAS) Levels in Polycystic Ovarian Syndrome (PCOS).
Polycystic Ovary Syndrome
Dehydroepiandrosterone sulfate and insulin resistance in patients with polycystic ovary syndrome.
Polycystic Ovary Syndrome
Development of a method for the measurement of dehydroepiandrosterone sulphate by liquid chromatography-tandem mass spectrometry.
Polycystic Ovary Syndrome
Effect of insulin and testosterone on androgen production and transcription of SULT2A1 in the NCI-h295r adrenocortical cell line.
Polycystic Ovary Syndrome
Influence of adrenal hyperandrogenism on the clinical and metabolic phenotype of women with polycystic ovary syndrome.
Polycystic Ovary Syndrome
PAPSS2 deficiency causes androgen excess via impaired DHEA sulfation - in vitro and in vivo studies in a family harboring two novel PAPSS2 mutations.
Polycystic Ovary Syndrome
Placental steroidogenesis in pregnant women with polycystic ovary syndrome.
Polycystic Ovary Syndrome
Premature Adrenarche and its Association with Cardiovascular Risk in Females.
Polycystic Ovary Syndrome
Prevalence and metabolic characteristics of adrenal androgen excess in hyperandrogenic women with different phenotypes.
Polycystic Ovary Syndrome
Prevalence of hyperandrogenemia in the polycystic ovary syndrome diagnosed by the National Institutes of Health 1990 criteria.
Polycystic Ovary Syndrome
Role of a CYP17 polymorphism in the regulation of circulating dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome.
Polycystic Ovary Syndrome
THE RARE CASE OF MIXED GONADAL DYSGENESIS, MOSAIC KARYOTYPE, PETROCLIVAL MENINGIOMA AND IDIOPATHIC HYPERDEHYDROEPIANDROSTERONISM.
Polycystic Ovary Syndrome
Troglitazone decreases adrenal androgen levels in women with polycystic ovary syndrome.
Polycystic Ovary Syndrome
Use of dexamethasone and clomiphene citrate in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome and normal dehydroepiandrosterone sulfate levels: a prospective, double-blind, placebo-controlled trial.
Polycystic Ovary Syndrome
Variants in SULT2A1 Affect the DHEA Sulphate to DHEA Ratio in Patients With Polycystic Ovary Syndrome But Not the Hyperandrogenic Phenotype.
Polycystic Ovary Syndrome
Visceral adiposity index and DHEAS are useful markers of diabetes risk in women with polycystic ovary syndrome.
Polycythemia
Aromatase activity after a short-course of letrozole administration in adult men at sea level and at high altitude (with or without excessive erythrocytosis).
Polymicrogyria
Banding pattern on polarized hair microscopic examination and unilateral polymicrogyria in a patient with steroid sulfatase deficiency.
Polymyalgia Rheumatica
Hypothalamic-pituitary-adrenal axis impairment in the pathogenesis of rheumatoid arthritis and polymyalgia rheumatica.
Polymyalgia Rheumatica
Low serum levels of DHEAS in untreated polymyalgia rheumatica/giant cell arteritis.
Pre-Eclampsia
Concentrations of corticotrophin-releasing hormone in the umbilical-cord blood of pregnancies complicated by pre-eclampsia.
Pre-Eclampsia
Early second-trimester maternal hyperandrogenemia and subsequent preeclampsia: a prospective study.
Pre-Eclampsia
Levels of sex steroid hormones and their receptors in women with preeclampsia.
Pre-Eclampsia
Maternal Preeclampsia and Androgens in the Offspring around Puberty: A Follow-Up Study.
Pre-Eclampsia
Progesterone and estradiol production by normal and preeclamptic placentas.
Pre-Eclampsia
Stable prolactin level after enhanced estradiol production following dehydroepiandrosterone sulfate.
Pre-Eclampsia
Steroid sulfatase is increased in the placentas and whole blood of women with early-onset preeclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Association between dehydroepiandrosterone-sulfate and attention in long-term survivors of childhood acute lymphoblastic leukemia treated with only chemotherapy.
Primary Ovarian Insufficiency
Adrenarche and pubarche in girls with turner syndrome during growth-promoting therapy with human growth hormone.
Primary Ovarian Insufficiency
The importance of adrenal hypoandrogenism in infertile women with low functional ovarian reserve: a case study of associated adrenal insufficiency.
Prostatic Diseases
Role of OATP transporters in steroid uptake by prostate cancer cells in vivo.
Prostatic Hyperplasia
Cross-sectional analysis between prostate volumes and serum sex hormones in Japanese men attending a urological clinic.
Prostatic Neoplasms
6-[2-(adamantylidene)-hydroxybenzoxazole]-O-sulfamate, a steroid sulfatase inhibitor for the treatment of androgen- and estrogen-dependent diseases.
Prostatic Neoplasms
Bacterial Lipopolysaccharides Induce Steroid Sulfatase Expression and Cell Migration through IL-6 Pathway in Human Prostate Cancer Cells.
Prostatic Neoplasms
Cytochrome P450 3A gene variation, steroid hormone serum levels and prostate cancer--The Rotterdam Study.
Prostatic Neoplasms
Differential metabolism of dehydroepiandrosterone sulfate and estrogen conjugates by normal or malignant AXC/SSh rat prostate cells and effects of these steroid conjugates on cancer cell proliferation in vitro.
Prostatic Neoplasms
Do differences in age specific androgenic steroid hormone levels account for differing prostate cancer rates between Arabs and Caucasians?
Prostatic Neoplasms
Induction of steroid sulfatase expression by tumor necrosis factor-? through phosphatidylinositol 3-kinase/Akt signaling pathway in PC-3 human prostate cancer cells.
Prostatic Neoplasms
Induction of steroid sulfatase expression in PC-3 human prostate cancer cells by insulin-like growth factor II.
Prostatic Neoplasms
Influence of Statins on Survival Outcome in Patients with Metastatic Castration Resistant Prostate Cancer Treated with Abiraterone Acetate.
Prostatic Neoplasms
Prostate cancer risk: the significance of differences in age related changes in serum conjugated and unconjugated steroid hormone concentrations between arab and caucasian men.
Prostatic Neoplasms
Statin Use at the Time of Initiation of Androgen Deprivation Therapy and Time to Progression in Patients With Hormone-Sensitive Prostate Cancer.
Prostatic Neoplasms
Steroid sulfatase and estrogen sulfotransferase in human prostate cancer.
Prostatic Neoplasms
Steroid sulfatase stimulates intracrine androgen synthesis and is a therapeutic target for advanced prostate cancer.
Prostatic Neoplasms
The endocrine profiles in men with localized and locally advanced prostate cancer treated with radical prostatectomy.
Prostatic Neoplasms
V89L polymorphism of the 5alpha-reductase Type II gene (SRD5A2), endogenous sex hormones, and prostate cancer risk.
Proteinuria
[High androgen plasmatic levels in women affected with pregnancy-induced hypertension]
Psoriasis
Blood dehydroepiandrosterone sulphate (DHEAS) levels in pemphigoid/pemphigus and psoriasis.
Puberty, Delayed
X-linked ichthyosis with hypogonadism: not always Kallmann's syndrome.
Puberty, Precocious
[Psychological behavior of girls with idiopathic central precocious puberty before and after treatment with gonadotropin-releasing hormone analogue]
Puberty, Precocious
[Relationship between serum dehydroepiandrosterone levels and female precocious puberty]
Pulmonary Disease, Chronic Obstructive
Dehydroepiandrosterone-sulfate serum levels and common age-related diseases: results from a cross-sectional Italian study of a general elderly population.
Pulmonary Disease, Chronic Obstructive
Estrogen Activation by Steroid Sulfatase increases Colorectal Cancer proliferation via GPER.
Pulmonary Disease, Chronic Obstructive
Increased levels of enzymes involved in local estradiol synthesis in chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Sex hormone alterations and systemic inflammation in chronic obstructive pulmonary disease.
Retroviridae Infections
Dehydroepiandrosterone (DHEA) sulfate prevents reduction in tissue vitamin E and increased lipid peroxidation due to murine retrovirus infection of aged mice.
Retroviridae Infections
Immune dysfunction during alcohol consumption and murine AIDS: the protective role of dehydroepiandrosterone sulfate.
Retroviridae Infections
Modulation of immune dysfunction during murine leukaemia retrovirus infection of old mice by dehydroepiandrosterone sulphate (DHEAS).
Rheumatic Diseases
Dehydroepiandrostenedione sulphate (DHEAS) levels predict high risk of rheumatoid arthritis (RA) in subclinical hypothyroidism.
Rhinitis, Allergic
Allergic disease as an association of steroid sulphatase deficiency.
Sarcopenia
Effect of DHEAS on skeletal muscle over the life span: the InCHIANTI study.
Sarcopenia
Sex hormones and sarcopenia in older persons.
Schistosomiasis mansoni
The relationships between dehydroepiandrosterone sulphate (DHEAS), the intensity of Schistosoma mansoni infection and parasite-specific antibody responses. A cross-sectional study in residents of endemic communities in north-east Ethiopia.
Scleroderma, Systemic
High prolactin and low dehydroepiandrosterone sulphate serum levels in patients with severe systemic sclerosis.
Seizures
Banding pattern on polarized hair microscopic examination and unilateral polymicrogyria in a patient with steroid sulfatase deficiency.
Seizures
Differential effects of antiepileptic drugs on neuroactive steroids in men with epilepsy.
Seizures
Effects of acute and chronic administration of neurosteroid dehydroepiandrosterone sulfate on neuronal excitability in mice.
Seizures
Mean daily plasma concentrations of beta-endorphin, leu-enkephalin, ACTH, cortisol, and DHEAS in epileptic patients with complex partial seizures evolving to generalized tonic-clonic seizures.
Seizures
Seizure frequency and cortisol and dehydroepiandrosterone sulfate (DHEAS) levels in women with epilepsy receiving antiepileptic drug treatment.
Seizures
The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol.
Sepsis
Adrenal androgens and the immune system.
Sepsis
Decreased levels of dehydroepiandrosterone sulphate in severe critical illness: a sign of exhausted adrenal reserve?
Sepsis
Dehydroepiandrosterone sulfate and dehydroepiandrosterone sulfate/cortisol ratio in cirrhotic patients with septic shock: another sign of hepatoadrenal syndrome?
Sepsis
Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock.
Sertoli Cell-Only Syndrome
Testicular steroid sulfatase overexpression is associated with Leydig cell dysfunction in primary spermatogenic failure.
Shock, Septic
Decreased levels of dehydroepiandrosterone sulphate in severe critical illness: a sign of exhausted adrenal reserve?
Shock, Septic
Dehydroepiandrosterone sulfate and dehydroepiandrosterone sulfate/cortisol ratio in cirrhotic patients with septic shock: another sign of hepatoadrenal syndrome?
Shock, Septic
Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock.
Skin Diseases
6-[2-(adamantylidene)-hydroxybenzoxazole]-O-sulfamate, a steroid sulfatase inhibitor for the treatment of androgen- and estrogen-dependent diseases.
Skin Diseases
Review: genetics of steroid sulphatase deficiency and X-linked ichthyosis.
Skin Neoplasms
Serum dehydroepiandrosterone and dehydroepiandrosterone sulfate and risk of melanoma or squamous cell carcinoma of the skin.
Smith-Lemli-Opitz Syndrome
Advances in prenatal screening for Down syndrome: I. general principles and second trimester testing.
Smith-Lemli-Opitz Syndrome
Are low maternal estriol levels a predictor for pro-opiomelanocortin (POMC) deficiency caused by POMC mutation during pregnancy?
Smith-Lemli-Opitz Syndrome
Low estriol levels in the maternal triple-marker screen as a predictor of isolated adrenocorticotropic hormone deficiency caused by a new mutation in the TPIT gene.
Smith-Lemli-Opitz Syndrome
Maternal serum unconjugated estriol as a predictor for Smith-Lemli-Opitz syndrome and other fetal conditions.
Smith-Lemli-Opitz Syndrome
Prevalence of steroid sulfatase deficiency in California according to race and ethnicity.
Solitary Kidney
Hypogonadotrophic hypogonadism with hyposmia, X-linked ichthyosis, and renal malformation syndrome.
Spinal Cord Injuries
Astrocyte Neuroprotection and Dehydroepiandrosterone.
Spinal Cord Ischemia
Dehydroepiandrosterone sulfate is neuroprotective in a reversible spinal cord ischemia model: possible involvement of GABA(A) receptors.
Starvation
Aromatase inhibitors and other novel agents in breast cancer treatment.
steroid 21-monooxygenase deficiency
Disproportionate suppression of dehydroepiandrosterone sulfate (DHEAS) in treated patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
steroid 21-monooxygenase deficiency
[Screening for congenital adrenal hyperplasia in pregnancy: results and perspectives].
steryl-sulfatase deficiency
3 beta-Hydroxysteroid dehydrogenase-isomerase activity in placentae from pregnancies complicated by steroid sulphatase deficiency.
steryl-sulfatase deficiency
: Recognising placental steroid sulphatase deficiency.
steryl-sulfatase deficiency
A new method for the determination of steroid sulphatase activity in leukocytes in X-linked recessive ichthyosis.
steryl-sulfatase deficiency
Abnormal androgen and oestrogen metabolism in men with steroid sulphatase deficiency and recessive X-linked ichthyosis.
steryl-sulfatase deficiency
Advances in prenatal screening for Down syndrome: I. general principles and second trimester testing.
steryl-sulfatase deficiency
Allergic disease as an association of steroid sulphatase deficiency.
steryl-sulfatase deficiency
Anabolic deficiencies in men with systolic heart failure: do co-morbidities and therapies really contribute significantly?
steryl-sulfatase deficiency
Antenatal detection of placental steroid sulphatase deficiency by measurement of urinary 16 alpha-hydroxydehydroepiandrosterone sulphate.
steryl-sulfatase deficiency
Antenatal detection of placental steroid sulphatase deficiency: use of a dehydroepiandrosterone sulphate loading test.
steryl-sulfatase deficiency
Antenatal diagnosis of steroid sulphatase deficiency: case report and literature survey.
steryl-sulfatase deficiency
Are low maternal estriol levels a predictor for pro-opiomelanocortin (POMC) deficiency caused by POMC mutation during pregnancy?
steryl-sulfatase deficiency
Association of dehydroepiandrosterone sulfate and testosterone deficiency with bone turnover in men with inflammatory bowel disease.
steryl-sulfatase deficiency
Association of undetectable unconjugated estriol on multiple marker screening with steroid sulfatase deficiency.
steryl-sulfatase deficiency
Banding pattern on polarized hair microscopic examination and unilateral polymicrogyria in a patient with steroid sulfatase deficiency.
steryl-sulfatase deficiency
Blood dehydroepiandrosterone sulphate (DHEAS) levels in pemphigoid/pemphigus and psoriasis.
steryl-sulfatase deficiency
Carrier identification in steroid sulphatase deficiency and recessive X-linked ichthyosis.
steryl-sulfatase deficiency
Characterization of a low copy repetitive element S232 involved in the generation of frequent deletions of the distal short arm of the human X chromosome.
steryl-sulfatase deficiency
Characterization of low-density lipoproteins from patients with recessive X-linked ichthyosis.
steryl-sulfatase deficiency
Characterization of the deletion breakpoints in a patient with steroid sulfatase deficiency.
steryl-sulfatase deficiency
Clinical pathologic correlation of superficial corneal opacities in X-linked ichthyosis.
steryl-sulfatase deficiency
Clinical spectrum of steroid sulfatase deficiency: X-linked recessive ichthyosis, birth complications and cryptorchidism.
steryl-sulfatase deficiency
Congenital hypopituitarism as a cause of undetectable estriol levels in the maternal triple-marker screen.
steryl-sulfatase deficiency
Contiguous gene syndromes due to deletions in the distal short arm of the human X chromosome.
steryl-sulfatase deficiency
Correction of steroid sulfatase deficiency by gene transfer into basal cells of tissue-cultured epidermis from patients with recessive X-linked ichthyosis.
steryl-sulfatase deficiency
Deficiencies in circulating testosterone and dehydroepiandrosterone sulphate, and depression in men with systolic chronic heart failure.
steryl-sulfatase deficiency
Deletion analysis maps ocular albinism proximal to the steroid sulphatase locus.
steryl-sulfatase deficiency
Deletion of exons 1-5 of the STS gene causing X-linked ichthyosis.
steryl-sulfatase deficiency
Deletion of the distal short arm of the X chromosome (Xp) in a patient with short stature, chondrodysplasia punctata, and X-linked ichthyosis due to steroid sulfatase deficiency.
steryl-sulfatase deficiency
Deletion pattern of the STS gene in X-linked ichthyosis in a Mexican population.
steryl-sulfatase deficiency
Determination of cholesteryl sulphate by isotope dilution-mass spectrometry for diagnosis of steroid sulphatase deficiency.
steryl-sulfatase deficiency
DHEAS deficiency during consumption of sustained-action prescribed opioids: evidence for opioid-induced inhibition of adrenal androgen production.
steryl-sulfatase deficiency
Does steroid sulfatase deficiency influence postpartum psychosis risk?
steryl-sulfatase deficiency
Dosage of the Sts gene in the mouse.
steryl-sulfatase deficiency
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
steryl-sulfatase deficiency
Enzymatic diagnosis of steroid sulfatase deficiency by high performance liquid chromatography.
steryl-sulfatase deficiency
Familial X-linked ichthyosis, steroid sulfatase deficiency, mental retardation, and nullisomy for Xp223-pter.
steryl-sulfatase deficiency
Foetal steroid sulphatase deficiency. A case report.
steryl-sulfatase deficiency
Four cases of pregnancy with low estrogen production due to placental enzymatic deficiency.
steryl-sulfatase deficiency
Frequency of steroid sulfatase deficiency in Hiroshima.
steryl-sulfatase deficiency
Frequent deletions of the human X chromosome distal short arm result from recombination between low copy repetitive elements.
steryl-sulfatase deficiency
Genetic heterogeneity of steroid sulfatase deficiency revealed with cDNA for human steroid sulfatase.
steryl-sulfatase deficiency
Gonadal and adrenal androgen deficiencies as independent predictors of increased cardiovascular mortality in men with type II diabetes mellitus and stable coronary artery disease.
steryl-sulfatase deficiency
Hair root analysis in X-linked ichthyosis.
steryl-sulfatase deficiency
Heterozygote detection in steroid sulphatase deficiency.
steryl-sulfatase deficiency
High levels of oxysterol sulfates in serum of patients with steroid sulfatase deficiency.
steryl-sulfatase deficiency
Human placental steryl-sulfatase. Enzyme purification, production of antisera, and immunoblotting reactions with normal and sulfatase-deficient placentas.
steryl-sulfatase deficiency
Human steroid sulphatase deficiency.
steryl-sulfatase deficiency
Hydrolysis of deoxycorticosterone-21-yl sulphate and dehydroepiandrosterone sulphate by microsomal preparations of human placentae: evidence for a common enzyme.
steryl-sulfatase deficiency
Ichthyosis of steroid sulphatase deficiency. Clinical study of 76 cases.
steryl-sulfatase deficiency
Ichthyosis. Reliability of clinical signs in the differentiation between autosomal dominant and sex-linked forms.
steryl-sulfatase deficiency
Ichthyosis: the skin manifestation of multiple sulfatase deficiency.
steryl-sulfatase deficiency
Increased cholesterol sulfate in plasma and red blood cell membranes of steroid sulfatase deficient patients.
steryl-sulfatase deficiency
Lactation in placental steroid sulphatase deficiency.
steryl-sulfatase deficiency
Lipoprotein electrophoresis in recessive X-linked ichthyosis.
steryl-sulfatase deficiency
Low maternal serum unconjugated estriol during prenatal screening as an indication of placental steroid sulfatase deficiency and X-linked ichthyosis.
steryl-sulfatase deficiency
Low or absent unconjugated estriol in pregnancy: an indicator for steroid sulfatase deficiency detectable by fluorescence in situ hybridization and biochemical analysis.
steryl-sulfatase deficiency
Maternal serum unconjugated estriol as a predictor for Smith-Lemli-Opitz syndrome and other fetal conditions.
steryl-sulfatase deficiency
Maternal steroid sulfatase deficiency--cause of high-risk pregnancy?
steryl-sulfatase deficiency
Maternal transmission of the 3 bp deletion within exon 7 of the STS gene in steroid sulfatase deficiency.
steryl-sulfatase deficiency
Maternal urine and serum steroid measurements to identify steroid sulfatase deficiency (STSD) in second trimester pregnancies.
steryl-sulfatase deficiency
Metabolism of 3H-dehydroepiandrosterone sulphate by subjects with steroid sulphatase deficiency.
steryl-sulfatase deficiency
Mild ichthyosis in a 4-year-old boy with multiple sulphatase deficiency.
steryl-sulfatase deficiency
Molecular heterogeneity of steroid sulfatase deficiency: a multicenter study on 57 unrelated patients, at DNA and protein levels.
steryl-sulfatase deficiency
More on X-linked ichthyosis, steroid sulfatase deficiency, and hypogonadism and anosmia.
steryl-sulfatase deficiency
Multipoint linkage analysis of steroid sulfatase (X-linked ichthyosis) and distal Xp markers.
steryl-sulfatase deficiency
Mutation report: a novel partial deletion of exons 2-10 of the STS gene in recessive X-linked ichthyosis.
steryl-sulfatase deficiency
Nonsyndromic types of ichthyoses - an update.
steryl-sulfatase deficiency
Novel point mutations in the steroid sulfatase gene in patients with X-linked ichthyosis: transfection analysis using the mutated genes.
steryl-sulfatase deficiency
Ocular findings in X-linked ichthyosis: a survey on 38 cases.
steryl-sulfatase deficiency
Placental steroid deficiency: association with arylsulfatase A deficiency.
steryl-sulfatase deficiency
Placental steroid sulfatase deficiency.
steryl-sulfatase deficiency
Placental steroid sulfatase deficiency: biochemical diagnosis and clinical review.
steryl-sulfatase deficiency
Placental steroid sulphatase deficiency.
steryl-sulfatase deficiency
Placental steroid sulphatase deficiency: an approach to antenatal care and delivery.
steryl-sulfatase deficiency
Placental sulfatase deficiency: maternal and fetal expression of steroid sulfatase deficiency and X-linked ichthyosis.
steryl-sulfatase deficiency
Prenatal detection of X-linked ichthyosis by maternal serum screening for Down syndrome.
steryl-sulfatase deficiency
Prenatal diagnosis of placental steroid sulfatase deficiency.
steryl-sulfatase deficiency
Prenatal diagnosis of sex differentiation disorders: the role of fetal ultrasound.
steryl-sulfatase deficiency
Prenatal diagnosis of X-linked ichthyosis using molecular cytogenetics.
steryl-sulfatase deficiency
Prenatal diagnosis of X-linked ichthyosis.
steryl-sulfatase deficiency
Prevalence of steroid sulfatase deficiency in California according to race and ethnicity.
steryl-sulfatase deficiency
Recognising placental steroid sulphatase deficiency.
steryl-sulfatase deficiency
Recurrent bilateral corneal erosions due to an association of epidermolysis bullosa simplex Köbner and X-linked ichthyosis with steroid sulfatase deficiency.
steryl-sulfatase deficiency
Regional assignment of the gene locus for steroid sulfatase.
steryl-sulfatase deficiency
Regulation of serum testosterone in men with steroid sulfatase deficiency: response to human chorionic gonadotropin.
steryl-sulfatase deficiency
Replacement therapy with DHEA plus corticosteroids in patients with chronic inflammatory diseases--substitutes of adrenal and sex hormones.
steryl-sulfatase deficiency
Reversion of aging-related DHEAS decline in mouse plasma alleviates aging-related glucose tolerance impairment by potentiation of glucose-stimulated insulin secretion of acute phase.
steryl-sulfatase deficiency
Review: genetics of steroid sulphatase deficiency and X-linked ichthyosis.
steryl-sulfatase deficiency
Role of steroid sulfatase in steroid homeostasis and characterization of the sulfated steroid pathway: Evidence from steroid sulfatase deficiency.
steryl-sulfatase deficiency
Role of the pseudoautosomal region in sex-chromosome pairing during male meiosis: meiotic studies in a man with a deletion of distal Xp.
steryl-sulfatase deficiency
Second-trimester maternal serum screening using alpha-fetoprotein, human chorionic gonadotrophin, and unconjugated oestriol: experience of a regional programme.
steryl-sulfatase deficiency
Sequence analysis of a partial deletion of the human steroid sulfatase gene reveals 3 bp of homology at deletion breakpoints.
steryl-sulfatase deficiency
Serum dehydroepiandrosterone sulfate, testosterone, and biochemical markers of bone turnover in elderly Thai men.
steryl-sulfatase deficiency
Serum steroid sulphates in ichthyosis.
steryl-sulfatase deficiency
Sex-linked ichthyosis and placental sulphatase C deficiency.
steryl-sulfatase deficiency
Simultaneous quantification of cholesterol sulfate, androgen sulfates, and progestagen sulfates in human serum by LC-MS/MS.
steryl-sulfatase deficiency
Somatic and germinal mosaicism for the steroid sulfatase gene deletion in a steroid sulfatase deficiency carrier.
steryl-sulfatase deficiency
Steroid sulfatase activity in human leukocytes.
steryl-sulfatase deficiency
Steroid sulfatase activity in leukocytes: a comparative study in 45,X; 46,Xi(Xq) and carriers of steroid sulfatase deficiency.
steryl-sulfatase deficiency
Steroid sulfatase deficiency and contiguous gene deletion syndrome amongst pregnant patients with low serum unconjugated estriols.
steryl-sulfatase deficiency
Steroid sulfatase deficiency and the genetics of the short arm of the human X chromosome.
steryl-sulfatase deficiency
Steroid sulfatase deficiency and X-linked ichthyosis.
steryl-sulfatase deficiency
Steroid sulfatase deficiency in Japanese patients: characterization of X-linked ichthyosis by using polymerase chain reaction.
steryl-sulfatase deficiency
Steroid Sulfatase Deficiency With Bilateral Periventricular Nodular Heterotopia.
steryl-sulfatase deficiency
Steroid sulfatase deficiency.
steryl-sulfatase deficiency
Steroid sulfatase deficiency: enzymatic studies using placenta and leucocytes in one family.
steryl-sulfatase deficiency
Steroid sulfatase-deficient mice exhibit endophenotypes relevant to Attention Deficit Hyperactivity Disorder.
steryl-sulfatase deficiency
Steroid sulphatase deficiency and hypogonadism.
steryl-sulfatase deficiency
Steroid sulphatase deficiency associated with testis cancer.
steryl-sulfatase deficiency
Steroid sulphatase deficiency disease.
steryl-sulfatase deficiency
Steroid sulphatase deficiency in patients initially diagnosed as ichthyosis vulgaris or recessive X-linked ichthyosis.
steryl-sulfatase deficiency
Steroid sulphatase deficiency is present in patients with the syndrome 'ichthyosis and male hypogonadism' and with 'Rud syndrome'.
steryl-sulfatase deficiency
Steroid sulphatase deficiency is the major cause of extremely low oestriol production at mid-pregnancy: a urinary steroid assay for the discrimination of steroid sulphatase deficiency from other causes.
steryl-sulfatase deficiency
Steroid sulphatase deficiency.
steryl-sulfatase deficiency
Steroid sulphatase deficiency. Steroid sulphatase and arylsulphatase C determination in normal and affected fibroblasts.
steryl-sulfatase deficiency
Steroid sulphatase deficiency: identification of heterozygotes using hydrolysis of dehydroepiandrosterone sulphate by peripheral leucocytes.
steryl-sulfatase deficiency
Steroid-resistant nephrotic syndrome associated with steroid sulfatase deficiency-x-linked recessive ichthyosis: a case report and review of literature.
steryl-sulfatase deficiency
Studies of the biochemical basis of steroid sulphatase deficiency--III. Phospholipid composition of microsomes from normal and steroid sulphatase deficient placentas.
steryl-sulfatase deficiency
Studies of the biochemical basis of steroid sulphatase deficiency: preliminary evidence suggesting a defect in membrane-enzyme structure.
steryl-sulfatase deficiency
Studies on cross-reacting material to steroid sulphatase in fibroblasts from patients affected by different types of steroid sulphatase deficiency.
steryl-sulfatase deficiency
Submicroscopic Xpter deletion in a boy with growth and mental retardation caused by a familial t(X;14).
steryl-sulfatase deficiency
The human arylsulfatase-C isoenzymes: two distinct genes that escape from X inactivation.
steryl-sulfatase deficiency
The nature of placental steroid sulphatase deficiency in man.
steryl-sulfatase deficiency
The role of antenatal oestrogen in post-partum human lactogenesis: evidence from oestrogen-deficient pregnancies.
steryl-sulfatase deficiency
Two cases of steroid sulfatase deficiency with complex phenotype due to contiguous gene deletions.
steryl-sulfatase deficiency
Unconjugated estriol as an indication for prenatal diagnosis of steroid sulfatase deficiency by in situ hybridization.
steryl-sulfatase deficiency
Urinary excretion of oestrone, oestradiol-17 beta and oestriol in pregnancies complicated by steroid sulphatase deficiency.
steryl-sulfatase deficiency
Very low maternal serum unconjugated estriol and prenatal diagnosis of steroid sulfatase deficiency.
steryl-sulfatase deficiency
X chromosome deletions detectable by flow cytometry in some patients with steroid sulphatase deficiency (X-linked ichthyosis).
steryl-sulfatase deficiency
X-chromosome inactivation: role in skin disease expression.
steryl-sulfatase deficiency
X-linked ichthyosis and X-linked placental sulfatase deficiency: a disease entity. Histochemical observations.
steryl-sulfatase deficiency
X-linked ichthyosis due to steroid sulfatase deficiency associated with hypogonadism and anosmia.
steryl-sulfatase deficiency
X-linked ichthyosis with hypogonadism: not always Kallmann's syndrome.
steryl-sulfatase deficiency
X-linked ichthyosis, due to steroid sulphatase deficiency, associated with Kallmann syndrome (hypogonadotropic hypogonadism and anosmia): linkage relationships with Xg and cloned DNA sequences from the distal short arm of the X chromosome.
steryl-sulfatase deficiency
X-linked ichthyosis: relation between cholesterol sulphate, dehydroepiandrosterone sulphate and patient's age.
steryl-sulfatase deficiency
X-linked recessive ichthyosis. Enzymatic diagnosis of affected males and female carriers.
steryl-sulfatase deficiency
[A Case of Steroid Sulfatase Deficiency Complicated by Bilateral Undescended Testis].
steryl-sulfatase deficiency
[Arylsulfatase C deficiency in leukocytes in patients and carrier of X-chromosome recessive ichthyosis]
steryl-sulfatase deficiency
[Biochemical study on steroid sulfatase and its clinical application to the obstetrics and gynecology]
steryl-sulfatase deficiency
[Genetic analysis of a rare case with Kallman syndrome and steroid sulfatase deficiency].
steryl-sulfatase deficiency
[Ichthyosis X. Clinical review and rapid identification using lipid electrophoresis]
steryl-sulfatase deficiency
[Identification of gene mutation and prenatal diagnosis in a family with X-linked ichthyosis].
steryl-sulfatase deficiency
[Occurrence of X-linked ichthyosis along with atopy]
steryl-sulfatase deficiency
[Placental steroid sulfatase deficiency. Reduced estriol production]
steryl-sulfatase deficiency
[Steroid sulfatase and placental deficiency. Current data as instigators of new research]
steryl-sulfatase deficiency
[Steroid sulphatase deficiency]
steryl-sulfatase deficiency
[Two cases of X-linked ichthyosis associated with myopathies]
Stroke
Are low dehydroepiandrosterone sulphate levels predictive for cardiovascular diseases? A review of prospective and retrospective studies.
Stroke
Dehydroepiandrosterone sulfate, incidence of myocardial infarction, and extent of atherosclerosis in men.
sulfate adenylyltransferase deficiency
Low DHEAS Concentration in a Girl Presenting with Short Stature and Premature Pubarche: A Novel PAPSS2 Gene Mutation.
Testicular Diseases
Absence of testicular steroid sulphatase activity in a boy with recessive X-linked ichthyosis and testicular maldescent.
Testicular Neoplasms
Lack of an association between testicular cancers and low steroid sulphatase activity in peripheral leucocytes.
Testicular Neoplasms
Steroid sulphatase deficiency associated with testis cancer.
Tetanus
DHEAS as an effective vaccine adjuvant in elderly humans. Proof-of-principle studies.
Thalassemia
Evaluation of the glucocorticoid, mineralocorticoid, and adrenal androgen secretion dynamics in a large cohort of patients aged 6-18 years with transfusion-dependent ?-thalassemia major, with an emphasis on the impact of cardiac iron load.
Thyroid Nodule
Decreased serum IGF-I and dehydroepiandrosterone sulphate may be risk factors for the development of reduced bone mass in postmenopausal women with endogenous subclinical hyperthyroidism.
Thyroiditis, Autoimmune
Dehydroepiandrosterone sulfate does not prevent spontaneous and iodine-induced lymphocytic thyroiditis and diabetes mellitus in the BB/Wor rat.
Thyrotoxicosis
Serum concentration of androstenediol and androstenediol sulfate in patients with hyperthyroidism and hypothyroidism.
Toxoplasmosis, Ocular
Serum levels of dehydroepiandrosterone sulfate (DHEAS) in ocular toxoplasmosis.
Trisomy 13 Syndrome
Second-trimester maternal serum screening using alpha-fetoprotein, human chorionic gonadotrophin, and unconjugated oestriol: experience of a regional programme.
Trisomy 18 Syndrome
Advances in prenatal screening for Down syndrome: I. general principles and second trimester testing.
Trisomy 18 Syndrome
Second-trimester maternal serum screening using alpha-fetoprotein, human chorionic gonadotrophin, and unconjugated oestriol: experience of a regional programme.
Tuberculosis
Dehydroepiandrosterone sulphate enhances IgG and Interferon-gamma production during immunization to tuberculosis in young but not aged mice.
Tuberculosis
The endocrinology of adrenal tuberculosis: the effects of tuberculosis on the hypothalamo-pituitary-adrenal axis and adrenocortical function.
Turner Syndrome
Advances in prenatal screening for Down syndrome: I. general principles and second trimester testing.
Turner Syndrome
Effect of Dosage of 17ß-Estradiol on Uterine Growth in Turner Syndrome-A Randomized Controlled Clinical Pilot Trial.
Turner Syndrome
Reduced androgen levels in adult turner syndrome: influence of female sex steroids and growth hormone status.
Turner Syndrome
The early dehydroepiandrosterone sulfate rise of adrenarche and the delay of pubarche indicate primary ovarian failure in Turner syndrome.
Urinary Bladder Neoplasms
Steroid sulfatase promotes invasion through epithelial-mesenchymal transition and predicts the progression of bladder cancer.
Uterine Cervical Neoplasms
Estrogen formation in endometrial and cervix cancer cell lines: Involvement of aromatase, steroid sulfatase and 17beta-hydroxysteroid dehydrogenases (types 1, 5, 7 and 12).
Uterine Cervical Neoplasms
Human steroid sulfatase induces Wnt/?-catenin signaling and epithelial-mesenchymal transition by upregulating Twist1 and HIF-1? in human prostate and cervical cancer cells.
Uterine Cervical Neoplasms
Induction of Integrin Signaling by Steroid Sulfatase in Human Cervical Cancer Cells.
Vascular Diseases
Dehydroepiandrosterone sulfate, diseases and mortality in a general aged population.
Vascular Diseases
Effects of dehydroepiandrosterone sulfate on cellular calcium responsiveness and vascular contractility.
Vascular System Injuries
Adrenal androgen dehydroepiandrosterone sulfate inhibits vascular remodeling following arterial injury.
Vertigo
Effects of the neurosteroid dehydroepiandrosterone sulfate on medial vestibular nucleus neurons.
Vitiligo
Association of serum cortisol and dehydroepiandrosterone sulfate (DHEAS) levels with psychological stress in patients with vitiligo
Whooping Cough
Metabotropic neurosteroid/sigma-receptor involved in stimulation of nociceptor endings of mice.
Wilms Tumor
New frontiers on the molecular underpinnings of hypospadias according to severity.
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