Information on EC 3.1.6.15 - N-sulfoglucosamine-3-sulfatase

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The expected taxonomic range for this enzyme is: Homo sapiens

EC NUMBER
COMMENTARY hide
3.1.6.15
-
RECOMMENDED NAME
GeneOntology No.
N-sulfoglucosamine-3-sulfatase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of sulfuric ester
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
N-sulfo-3-sulfoglucosamine 3-sulfohydrolase
The enzyme from Flavobacterium heparinum also hydrolyses N-acetyl-D-glucosamine 3-O-sulfate; the mammalian enzyme acts only on the disulfated residue.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
methyl-2-deoxy-2-sulfamino-alpha-D-glucopyranoside 3-sulfate + H2O
methyl-2-deoxy-2-sulfamino-alpha-D-glucopyranoside + sulfate
show the reaction diagram
-
-
-
?
N2-sulfo-D-glucosamine 3-sulfate unit + H2O
D-glucosamine units + sulfate
show the reaction diagram
-
of heparin
of heparin
?
N2-sulfo-D-glucosamine 3-sulfate units + H2O
?
show the reaction diagram
-
of heparin
-
-
-
additional information
?
-
-
not: 4- and 6-O-sulfate esters
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
N2-sulfo-D-glucosamine 3-sulfate units + H2O
?
show the reaction diagram
-
of heparin
-
-
-
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
PO43-
-
50% reduction of activity at 0.1 mM
SO42-
-
50% reduction of activity at 0.8 mM
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5 - 7.2
-
less than 60% of maximal activity above and below
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
70fold
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