Information on EC 3.1.6.11 - disulfoglucosamine-6-sulfatase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
3.1.6.11
-
RECOMMENDED NAME
GeneOntology No.
disulfoglucosamine-6-sulfatase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-N,6-O-disulfo-D-glucosamine + H2O = 2-N-sulfo-D-glucosamine + sulfate
show the reaction diagram
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
heparin degradation
-
-
SYSTEMATIC NAME
IUBMB Comments
2-N,6-O-disulfo-D-glucosamine 6-sulfohydrolase
May be identical with EC 3.1.6.14 N-acetylglucosamine-6-sulfatase.
CAS REGISTRY NUMBER
COMMENTARY hide
37288-32-7
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
cow
-
-
Manually annotated by BRENDA team
Tagelus gibbus
mollusc
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(glucosamine O,N-disulfate)-(iduronic acid O-sulfate)-(3H-anhydromannitol O-sulfate) + H2O
?
show the reaction diagram
-
substrate prepared from degradation products of heparin
-
-
?
glucosamine-2,6-disulfate + H2O
glucosamine-6-sulfate + SO42-
show the reaction diagram
-
substrate yielded from enzymatic degradation of heparin
-
?
glucosamine-N-sulfate + H2O
glucosamine + SO42-
show the reaction diagram
-
-
-
?
heparan sulfate + H2O
?
show the reaction diagram
methyl glycoside 6-O-sulfate + H2O
?
show the reaction diagram
-
-
-
-
?
methyl-2-sulfamino2-deoxy-alpha-D-glucopyranoside 3-sulfate + H2O
?
show the reaction diagram
-
-
-
-
?
methyl-2-sulfamino2-deoxy-alpha-D-glucopyranoside 6-sulfate + H2O
?
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
heparan sulfate + H2O
?
show the reaction diagram
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NaCl
-
0.16 M 50% inhibition
PO43-
-
0.2 mM 22% inhibition
SO32-
-
0.2 mM 97% inhibition
SO42-
-
0.2 mM 43% inhibition
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.16
NaCl
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4.1
-
-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
Tagelus gibbus
-
-
Manually annotated by BRENDA team
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial