Information on EC 3.1.6.10 - chondro-6-sulfatase

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The expected taxonomic range for this enzyme is: Proteus vulgaris

EC NUMBER
COMMENTARY hide
3.1.6.10
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RECOMMENDED NAME
GeneOntology No.
chondro-6-sulfatase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + sulfate
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of sulfuric ester
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
chondroitin sulfate degradation I (bacterial)
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SYSTEMATIC NAME
IUBMB Comments
4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase
Also acts on the saturated analogue and N-acetyl-D-galactosamine 4,6-disulfate, but not higher oligosaccharides, nor any 4-sulfate
CAS REGISTRY NUMBER
COMMENTARY hide
9045-76-5
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-deoxy-alpha-threo-hex-enopyranosyluronic acid-(1-3)-beta-D-2-deoxy-2-aminogalactopyranose 4,6-disulfate + H2O
4-deoxy-alpha-threo-hex-enopyranosyluronic acid-(1-3)-beta-D-2-deoxy-2-aminogalactopyranose 4-sulfate + sulfate
show the reaction diagram
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with capillary electrophoresis
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?
4-deoxy-alpha-threo-hex-enopyranosyluronic acid-(1-3)-beta-D-2-deoxy-2-aminogalactopyranose 6-sulfate + H2O
4-deoxy-alpha-threo-hex-enopyranosyluronic acid-(1-3)-beta-D-2-deoxy-2-aminogalactopyranose + sulfate
show the reaction diagram
4-deoxy-alpha-threo-hex-enopyranosyluronic acid-2-sulfate-(1-3)-beta-D-2-deoxy-2-aminogalactopyranose 4,6-disulfate + H2O
4-deoxy-alpha-threo-hex-enopyranosyluronic acid-2-sulfate-(1-3)-beta-D-2-deoxy-2-aminogalactopyranose 4-sulfate + sulfate
show the reaction diagram
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with capillary electrophoresis
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?
4-deoxy-alpha-threo-hex-enopyranosyluronic acid-2-sulfate-(1-3)-beta-D-2-deoxy-2-aminogalactopyranose 6-sulfate + H2O
4-deoxy-alpha-threo-hex-enopyranosyluronic acid-2-sulfate-(1-3)-beta-D-2-deoxy-2-aminogalactopyranose + sulfate
show the reaction diagram
4-deoxy-beta-D-gluc-4-enuronosyl-(1,4)-N-acetyl-D-galactosamine 6-sulfate + H2O
4-deoxy-beta-D-gluc-4-enuronosyl-(1,4)-N-acetyl-D-galactosamine + sulfate + 2 H+
show the reaction diagram
acetylchondrosin 6-sulfate + H2O
acetylchondrosin + sulfate
show the reaction diagram
glucuronic acid 6-sulfate + H2O
glucuronic acid + sulfate
show the reaction diagram
N-acetyl-D-galactosamine 4,6-disulfate + H2O
N-acetyl-D-galactosamine 4-sulfate + sulfate
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
4-deoxy-beta-D-gluc-4-enuronosyl-(1,4)-N-acetyl-D-galactosamine 6-sulfate + H2O
4-deoxy-beta-D-gluc-4-enuronosyl-(1,4)-N-acetyl-D-galactosamine + sulfate + 2 H+
show the reaction diagram
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
acetate
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
copurification with chondroitinase ABC; partial
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