Reference on EC 3.1.4.54 - N-acetylphosphatidylethanolamine-hydrolysing phospholipase D
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ueda, N.; Okamoto, Y.; Morishita, J.
N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: a novel enzyme of the beta-lactamase fold family releasing anandamide and other N-acylethanolamines
Life Sci.
77
1750-1758
2005
Rattus norvegicus (Q769K2), Mus musculus (Q8BH82)
Wang, J.; Okamoto, Y.; Morishita, J.; Tsuboi, K.; Miyatake, A.; Ueda, N.
Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-beta-lactamase family
J. Biol. Chem.
281
12325-12335
2006
Homo sapiens (Q6IQ20), Rattus norvegicus (Q769K2)
Egertova, M.; Simon, G.M.; Cravatt, B.F.; Elphick, M.R.
Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules
J. Comp. Neurol.
506
604-615
2008
Mus musculus (Q8BH82), Mus musculus
Fezza, F.; Gasperi, V.; Mazzei, C.; Maccarrone, M.
Radiochromatographic assay of N-acyl-phosphatidylethanolamine-specific phospholipase D activity
Anal. Biochem.
339
113-120
2005
Mus musculus (Q8BH82), Mus musculus
Okamoto, Y.; Morishita, J.; Wang, J.; Schmid, P.C.; Krebsbach, R.J.; Schmid, H.H., Ueda, N.
Mammalian cells stably overexpressing N-acylphosphatidylethanolamine-hydrolysing phospholipase D exhibit significantly decreased levels of N-acylphosphatidylethanolamines
Biochem. J.
389
241-247
2005
Mus musculus (Q8BH82)
Leung, D.; Saghatelian, A.; Simon, G.M.; Cravatt, B.F.
Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids
Biochemistry
45
4720-4726
2006
Mus musculus (Q8BH82)
Okamoto, Y.; Wang, J.; Morishita, J.; Ueda, N.
Biosynthetic pathways of the endocannabinoid anandamide
Chem. Biodivers.
4
1842-1857
2007
Homo sapiens (Q6IQ20), Rattus norvegicus (Q769K2), Mus musculus (Q8BH82)
Liu, Q.; Tonai, T.; Ueda, N.
Activation of N-acylethanolamine-releasing phospholipase D by polyamines
Chem. Phys. Lipids
115
77-84
2002
Rattus norvegicus (Q769K2)
Petersen, G.; Pedersen, A.H.; Pickering, D.S.; Begtrup, M.; Hansen, H.S.
Effect of synthetic and natural phospholipids on N-acylphosphatidylethanolamine-hydrolyzing phospholipase D activity
Chem. Phys. Lipids
162
53-61
2009
Homo sapiens (Q6IQ20)
Petersen, G.; Hansen, H.S.
N-Acylphosphatidylethanolamine-hydrolysing phospholipase D lacks the ability to transphosphatidylate
FEBS Lett.
455
41-44
1999
Rattus norvegicus (Q769K2)
Wang, J.; Zhao, L.Y.; Uyama, T.; Tsuboi, K.; Wu, X.X., Kakehi, Y.; Ueda, N.
Expression and secretion of N-acylethanolamine-hydrolysing acid amidase in human prostate cancer cells
J. Biochem.
144
685-690
2008
Homo sapiens
Okamoto, Y.; Morishita, J.; Tsuboi, K.; Tonai, T.; Ueda, N.
Molecular characterization of a phospholipase D generating anandamide and its congeners
J. Biol. Chem.
279
5298-5305
2003
Rattus norvegicus (Q769K2)
Guo, Y.; Wang, H.; Okamoto, Y.; Ueda, N.; Kingsley, P.J.; Marnett, L.J.; Schmid, H.H.; Das, S.K.; Dey, S.K.
N-Acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation
J. Biol. Chem.
280
23429-23432
2005
Mus musculus (Q8BH82)
Morishita, J.; Okamoto, Y.; Tsuboi, K.; Ueno, M.; Sakamoto, H.; Maekawa, N.; Ueda N.
Regional distribution and age-dependent expression of N-acylphosphatidylethanolamine-hydrolyzing phospholipase D in rat brain
J. Neurochem.
94
753-762
2005
Rattus norvegicus (Q769K2)
Nyilas, R.; Dudok, B.; Urbn, G.M.; Mackie, K.; Watanabe, M.; Cravatt, B.F.; Freund, T.F.; Katona, I.
Enzymatic machinery for endocannabinoid biosynthesis associated with calcium stores in glutamatergic axon terminals
J. Neurosci.
28
1058-1063
2008
Mus musculus (Q8BH82)
Zhu, C.; Solorzano, C.; Sahar, S.; Realini, N.; Fung, E.; Sassone-Corsi, P.; Piomelli, D.
Proinflammatory stimuli control NAPE-PLD expression in macrophages
Mol. Pharmacol.
79
786-792
2011
Mus musculus (Q8BH82)
Wang, J.; Okamoto, Y.; Tsuboi, K.; Ueda, N.
The stimulatory effect of phosphatidylethanolamine on N-acylphosphatidylethanolamine-hydrolyzing phospholipase D (NAPE-PLD)
Neuropharmacology
54
8-15
2007
Rattus norvegicus (Q769K2)
Cristino, L.; Starowicz, K.; de Petrocellis, L.; Morishita, J.; Ueda, N.; Guglielmotti, V.; di Marzo, V.
Immunohistochemical localization of anabolic and catabolic enzymes for anandamide and other putative endovanilloids in the hippocampus and cerebellar cortex of the mouse brain
Neuroscience
151
955-968
2008
Mus musculus (Q8BH82), Mus musculus
Nagy, B.; Fedonidis, C.; Photiou, A.; Wahba, J.; Paule, C.C.; Ma, D.; Buluwela, L.; Nagy, I.
Capsaicin-sensitive primary sensory neurons in the mouse express N-acyl phosphatidylethanolamine phospholipase D
Neuroscience
161
572-577
2009
Mus musculus (Q8BH82), Mus musculus
Wang, J.; Ueda, N.
Biology of endocannabinoid synthesis system
Prostaglandins Other Lipid Mediat.
89
112-119
2009
Canis lupus familiaris, Homo sapiens (Q6IQ20), Rattus norvegicus (Q769K2), Mus musculus (Q8BH82)
Wellner, N.; Tsuboi, K.; Madsen, A.N.; Holst, B.; Diep, T.A.; Nakao, M.; Tokumura, A.; Burns, M.P.; Deutsch, D.G.; Ueda, N.; Hansen, H.S.
Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice
Biochim. Biophys. Acta
1811
508-512
2011
Mus musculus, Mus musculus C57BL/6
Tsuboi, K.; Okamoto, Y.; Ikematsu, N.; Inoue, M.; Shimizu, Y.; Uyama, T.; Wang, J.; Deutsch, D.G.; Burns, M.P.; Ulloa, N.M.; Tokumura, A.; Ueda, N.
Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways
Biochim. Biophys. Acta
1811
565-577
2011
Mus musculus, Mus musculus C57BL/6
Rivera, P.; Arrabal, S.; Vargas, A.; Blanco, E.; Serrano, A.; Pavon, F.J.; Rodriguez de Fonseca, F.; Suarez, J.
Localization of peroxisome proliferator-activated receptor alpha (PPARalpha) and N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) in cells expressing the Ca(2+)-binding proteins calbindin, calretinin, and parvalbumin in the adult rat hippocampus
Front. Neuroanat.
8
12
2014
Rattus norvegicus
Hegyi, Z.; Hollo, K.; Kis, G.; Mackie, K.; Antal, M.
Differential distribution of diacylglycerol lipase-alpha and N-acylphosphatidylethanolamine-specific phospholipase d immunoreactivity in the superficial spinal dorsal horn of rats
Glia
60
1316-1329
2012
Rattus norvegicus
Reguero, L.; Puente, N.; Elezgarai, I.; Ramos-Uriarte, A.; Gerrikagoitia, I.; Bueno-Lopez, J.L.; Donate, F.; Grandes, P.
Subcellular localization of NAPE-PLD and DAGL-alpha in the ventromedial nucleus of the hypothalamus by a preembedding immunogold method
Histochem. Cell Biol.
141
543-550
2014
Mus musculus
Pickel, V.M.; Shobin, E.T.; Lane, D.A.; Mackie, K.
Cannabinoid-1 receptors in the mouse ventral pallidum are targeted to axonal profiles expressing functionally opposed opioid peptides and contacting N-acylphosphatidylethanolamine-hydrolyzing phospholipase D terminals
Neuroscience
227
10-21
2012
Mus musculus
Scott, S.; Spencer, C.; OReilly, M.; Brown, K.; Lavieri, R.; Cho, C.; Jung, D.; Larock, R.; Brown, H.; Lindsley, C.
Discovery of desketoraloxifene analogues as inhibitors of mammalian, Pseudomonas aeruginosa, and NAPE phospholipase D enzymes
ACS Chem. Biol.
10
421-432
2015
Homo sapiens
Leishman, E.; Mackie, K.; Luquet, S.; Bradshaw, H.B.
Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain
Biochim. Biophys. Acta
1861
491-500
2016
Mus musculus (Q8BH82)
Castellani, B.; Diamanti, E.; Pizzirani, D.; Tardia, P.; Maccesi, M.; Realini, N.; Magotti, P.; Garau, G.; Bakkum, T.; Rivara, S.; Mor, M.; Piomelli, D.
Synthesis and characterization of the first inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD)
Chem. Commun. (Camb.)
53
12814-12817
2017
Homo sapiens (Q6IQ20)
Correa, F.; De Laurentiis, A.; Franchi, A.M.
Ethanol downregulates N-acyl phosphatidylethanolamine-phospholipase D expression in BV2 microglial cells via epigenetic mechanisms
Eur. J. Pharmacol.
786
224-233
2016
Mus musculus (Q8BH82)
Inoue, M.; Tsuboi, K.; Okamoto, Y.; Hidaka, M.; Uyama, T.; Tsutsumi, T.; Tanaka, T.; Ueda, N.; Tokumura, A.
Peripheral tissue levels and molecular species compositions of N-acyl-phosphatidylethanolamine and its metabolites in mice lacking N-acyl-phosphatidylethanolamine-specific phospholipase D
J. Biochem.
162
449-458
2017
Mus musculus (Q8BH82)
Chen, Z.; Zhang, Y.; Guo, L.; Dosoky, N.; de Ferra, L.; Peters, S.; Niswender, K.D.; Davies, S.S.
Leptogenic effects of NAPE require activity of NAPE-hydrolyzing phospholipase D
J. Lipid Res.
58
1624-1635
2017
Mus musculus (Q8BH82)
Lin, L.; Metherel, A.H.; Kitson, A.P.; Alashmali, S.M.; Hopperton, K.E.; Trepanier, M.O.; Jones, P.J.; Bazinet, R.P.
Dietary fatty acids augment tissue levels of n-acylethanolamines in n-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) knockout mice
J. Nutr. Biochem.
62
134-142
2018
Mus musculus (Q8BH82)
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