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most highly expressed in pancreas followed by brain, heart, thyroid, skeletal muscle, eye, ovary, submaxillary gland, epididymus, and liver
brenda
-
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axillae
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-
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-
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brenda
PDE4D11 expression levels increase in the cerebellum with progressive age
brenda
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highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
brenda
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
brenda
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lowering cyclic adenosine-3',5'-monophosphate levels by expression of a cAMP-specific phosphodiesterase decreases intrinsic pulsatile gonadotropin-releasing hormone secretion from GT1 cells
brenda
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macrophage cell
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-
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-
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-
-
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PDE7A1
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PDE4B. Ablation of PDE4B partially protects mice from LPS-induced shock
brenda
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-
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highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
brenda
PDE7A1
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-
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PDE7A1
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-
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highest expression level
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of newborn mice
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PDE7A1 co-localizes with PKA II in the Golgi centrosome region
brenda
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
brenda
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PDE4B5 is brain-specific
brenda
PDE7A1
brenda
in the brain, PDE4D11 expression levels increase in the cerebellum, but decrease in the hippocampus with progressive age
brenda
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isoforms PDE4A, PDE4D, PDE7A, PDE8A, PDE8B show an age-related increase or decrease in mRNA expression in at least 1 of the 4 brain regions examined (hippocampus, cortex, striatum, and cerebellum). mRNA expression of isoforms PDE7A, PDE7B does not change with age. Age-related increases in PDE11A4, PDE8A3, PDE8A4/5, and PDE1C1 protein expression are confirmed in hippocampus of old versus young rodents, as are age-related increases in PDE8A3 protein expression in the striatum
brenda
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-
brenda
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age-related increases in isoform PDE8A3 protein expression are confirmed in hippocampus of old versus young rodents
brenda
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-
brenda
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
brenda
PDE7A2
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lowest expression in heart
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neonatal cardiac myocyte
brenda
PDE4D11 expression levels decrease in the hippocampus with progressive age
brenda
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age-related increases in isoforms PDE8A3, PDE8A4/5 and PDE1C1 protein expression are confirmed in hippocampus of old versus young rodents
brenda
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-
brenda
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highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
brenda
PDE7A1
brenda
-
-
brenda
highest expression level
brenda
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
brenda
-
-
brenda
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weak activity
brenda
PDE7A1
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weak activity
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highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
brenda
PDE7A2
brenda
-
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weak activity
brenda
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order. In testis PDE8 is expressed in the seminiferous epithelium in a stage-specific manner
brenda
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Giorgi, M.; Caniglia, C.; Scarsella, G.; Augusti-Tocco, G.
Characterization of 3':5' cyclic nucleotide phosphodiesterase activities of mouse neuroblastoma N18TG2 cells
FEBS Lett.
324
76-80
1993
Mus musculus
brenda
Dlaboga, D.; Hajjhussein, H.; O'Donnell J.M.
Regulation of phosphodiesterase-4 (PDE4) expression in mouse brain by repeated antidepressant treatment: Comparison with rolipram
Brain Res.
1096
104-112
2006
Mus musculus
brenda
Han, P.; Sonati, P.; Rubin, C.; Michaeli, T.
PDE7A1, a cAMP-specific phosphodiesterase, inhibits cAMP-dependent protein kinase by a direct interaction with C
J. Biol. Chem.
281
15050-15057
2006
Mus musculus
brenda
Jin, S.L.; Lan, L.; Zoudilova, M.; Conti, M.
Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages
J. Immunol.
175
1523-1531
2005
Mus musculus
brenda
Cheung, Y.F.; Kan, Z.; Garrett-Engele, P.; Gall, I.; Murdoch, H.; Baillie, G.S.; Camargo, L.M.; Johnson, J.M.; Houslay, M.D.; Castle, J.C.
PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6)
J. Pharmacol. Exp. Ther.
322
600-609
2007
Mus musculus, Homo sapiens (Q07343), Homo sapiens
brenda
Brown, D.M.; Hutchison, L.; Donaldson, K.; MacKenzie, S.J.; Dick, C.A.; Stone, V.
The effect of oxidative stress on macrophages and lung epithelial cells: the role of phosphodiesterases 1 and 4
Toxicol. Lett.
168
1-6
2007
Homo sapiens, Mus musculus
brenda
Gardner, C.; Robas, N.; Cawkill, D.; Fidock, M.
Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase
Biochem. Biophys. Res. Commun.
272
186-192
2000
Homo sapiens (Q9NP56), Homo sapiens, Mus musculus (Q9QXQ1), Mus musculus
brenda
Cherry, J.A.; Thompson, B.E.; Pho, V.
Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse
Biochim. Biophys. Acta
1518
27-35
2001
Mus musculus (O89084), Mus musculus (Q9QXI7), Mus musculus
brenda
Houslay, M.D.; Baillie, G.S.; Maurice, D.H.
cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling
Circ. Res.
100
950-966
2007
Homo sapiens (P27815), Homo sapiens (Q07343), Homo sapiens (Q08499), Mus musculus (Q01063)
brenda
Horvath, A.; Giatzakis, C.; Tsang, K.; Greene, E.; Osorio, P.; Boikos, S.; Libe, R.; Patronas, Y.; Robinson-White, A.; Remmers, E.; Bertherat, J.; Nesterova, M.; Stratakis, C.A.
A cAMP-specific phosphodiesterase (PDE8B) that is mutated in adrenal hyperplasia is expressed widely in human and mouse tissues: a novel PDE8B isoform in human adrenal cortex
Eur. J. Hum. Genet.
16
1245-1253
2008
Homo sapiens, Homo sapiens (O95263), Mus musculus
brenda
Yoshida, H.; Beltran-Parrazal, L.; Butler, P.; Conti, M.; Charles, A.C.; Weiner, R.I.
Lowering cyclic adenosine-3',5'-monophosphate (cAMP) levels by expression of a cAMP-specific phosphodiesterase decreases intrinsic pulsatile gonadotropin-releasing hormone secretion from GT1 cells
Mol. Endocrinol.
17
1982-1990
2003
Mus musculus
brenda
Soderling, S.H.; Bayuga, S.J.; Beavo, J.A.
Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase
Proc. Natl. Acad. Sci. USA
95
8991-8996
1998
Mus musculus (O88502), Mus musculus
brenda
Hetman, J.M.; Soderling, S.H.; Glavas, N.A.; Beavo, J.A.
Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase
Proc. Natl. Acad. Sci. USA
97
472-476
2000
Mus musculus (P70453), Mus musculus (Q9QXQ1)
brenda
Lynex, C.N.; Li, Z.; Chen, M.L.; Toh, K.Y.; Low, R.W.; Goh, D.L.; Tay, S.K.
Identification and molecular characterization of a novel PDE4D11 cAMP-specific phosphodiesterase isoform
Cell. Signal.
20
2247-2255
2008
Mus musculus (B1PSD9), Mus musculus
brenda
Ivey, F.D.; Demirbas, D.; Allain, C.; Hoffmann, C.S.
Development of a fission yeast-based high-throughput screen to identify chemical regulators of cAMP phosphodiesterases
J. Biomol. Screen.
13
62-71
2008
Mus musculus
brenda
Nishi, A.; Kuroiwa, M.; Miller, D.B.; O'Callaghan, J.P.; Bateup, H.S.; Shuto, T.; Sotogaku, N.; Fukuda, T.; Heintz, N.; Greengard, P.; Snyder, G.L.
Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum
J. Neurosci.
28
10460-10471
2008
Mus musculus
brenda
De Arcangelis, V.; Soto, D.; Xiang, Y.
Phosphodiesterase 4 and phosphatase 2A differentially regulate cAMP/protein kinase a signaling for cardiac myocyte contraction under stimulation of beta1 adrenergic receptor
Mol. Pharmacol.
74
1453-1462
2008
Mus musculus
brenda
Lee, F.P.; Shih, C.M.; Shen, H.Y.; Chen, C.M.; Chen, C.M.; Ko, W.C.
Ayanin, a non-selective phosphodiesterase 1-4 inhibitor, effectively suppresses ovalbumin-induced airway hyperresponsiveness without affecting xylazine/ketamine-induced anesthesia
Eur. J. Pharmacol.
635
198-203
2010
Mus musculus
brenda
Cashman, J.R.; Voelker, T.; Zhang, H.T.; ODonnell, J.M.
Dual inhibitors of phosphodiesterase-4 and serotonin reuptake
J. Med. Chem.
52
1530-1539
2009
Mus musculus
brenda
Tsai, L.C.; Shimizu-Albergine, M.; Beavo, J.A.
The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland
Mol. Pharmacol.
79
639-648
2011
Mus musculus
brenda
Kelly, M.P.; Adamowicz, W.; Bove, S.; Hartman, A.J.; Mariga, A.; Pathak, G.; Reinhart, V.; Romegialli, A.; Kleiman, R.J.
Select 3,5-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain
Cell. Signal.
26
383-397
2014
Mus musculus, Rattus norvegicus
brenda
Mika, D.; Richter, W.; Westenbroek, R.E.; Catterall, W.A.; Conti, M.
PDE4B mediates local feedback regulation of beta1-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes
J. Cell Sci.
127
1033-1042
2014
Mus musculus
brenda
Cai, Y.; Nagel, D.J.; Zhou, Q.; Cygnar, K.D.; Zhao, H.; Li, F.; Pi, X.; Knight, P.A.; Yan, C.
Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia
Circ. Res.
116
1120-1132
2015
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Guo, L.; Luo, L.; Ju, R.; Chen, C.; Zhu, L.; Li, J.; Yu, X.; Ye, C.; Zhang, D.
Carboxyamidotriazole A novel inhibitor of both cAMP-phosphodiesterases and cGMP-phosphodiesterases
Eur. J. Pharmacol.
746
14-21
2015
Mus musculus, Rattus norvegicus
brenda