Information on EC 3.1.4.51 - glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Mark a special word or phrase in this record:
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Rattus norvegicus

EC NUMBER
COMMENTARY
3.1.4.51
-
RECOMMENDED NAME
GeneOntology No.
glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
6-(D-glucose-1-phospho)-D-mannosylglycoprotein + H2O = alpha-D-glucose 1-phosphate + D-mannosylglycoprotein
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hydrolysis of phosphoric diester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
6-(D-glucose-1-phospho)-D-mannosylglycoprotein glucose-1-phosphohydrolase
The enzyme is specific for the product of EC 2.7.8.19 UDP-glucose---glycoprotein glucose phosphotransferase.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
alpha-glucose 1-phosphate phosphodiesterase
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
123940-44-3
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
rat, Sprague-Dawley
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
6-(D-glucose-1-phospho)-D-mannosylglycoprotein + H2O
D-glucose alpha-1-phosphate + D-mannosylglycoprotein
show the reaction diagram
-
-, important in the regulation of secretion, reaction accompanying regulated secretory release
-
?
additional information
?
-
-
enzyme is unable to remove alpha-glucose-1-phosphate from UDPglucose or glycosylphosphoryldolichol
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
6-(D-glucose-1-phospho)-D-mannosylglycoprotein + H2O
D-glucose alpha-1-phosphate + D-mannosylglycoprotein
show the reaction diagram
-
important in the regulation of secretion, reaction accompanying regulated secretory release
-
?
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
PO43-
-
phosphate is able to even partially slow the degradation
additional information
-
not effectively inhibited by castanospermine, 1-deoxynojirimycin, bromoconduritol, tartrate, fluoride, molybdate or beta-glycerophosphate
-
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
pI VALUE
pI VALUE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
2
3.2
-
isoelectric focusing
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE