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Information on EC 3.1.4.50 - glycosylphosphatidylinositol phospholipase D
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3.1.4.50 glycosylphosphatidylinositol phospholipase DIUBMB Comments
This enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure. It therefore cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors, but does so by hydrolysis, whereas glycosylphosphatidylinositol diacylglycerol-lyase (EC 4.6.1.14) does so by elimination. It acts on plasma membranes only after solubilization of the substrate with detergents or solvents, but it may act on intracellular membranes.
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Word Map
- 3.1.4.50
-
gpi-anchored
- medicine
-
gpi-phospholipase
- gpi-plc
-
glycosyl-phosphatidylinositol
-
3hmyristate-labeled
-
3hethanolamine
- diagnostics
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
gpi-pld, glycosylphosphatidylinositol-specific phospholipase d, gpld1, gpi-specific phospholipase d, glycosylphosphatidylinositol phospholipase d, pi-g pld, phosphatidylinositol-specific phospholipase d, glycosylphosphatidylinositol-phospholipase d, glycoprotein phospholipase d, phosphatidylinositol phospholipase d, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
glycoprotein phospholipase D
-
-
-
-
glycosylphosphatidylinositol-specific phospholipase D
GPI-PLD
GPI-specific phospholipase D
Gpld1
phosphatidylinositol phospholipase D
-
-
-
-
phosphatidylinositol-specific phospholipase D
-
-
-
-
phospholipase D, phosphatidylinositol
-
-
-
-
PI-G PLD
-
-
-
-
glycosylphosphatidylinositol-specific phospholipase D
-
-
GPI-PLD
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + 3-sn-phosphatidate
this enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure. It therefore cleaves proteins from the lipid part of the glycosylphosphatidylinositol anchors, but does so by hydrolysis, whereas glycosylphosphatidylinositol diacylglycerol-lyase, EC 4.6.1.14, does so by elimination. It acts on plasma membranes only after solubilization of the substrate with detergents or solvents, but it may act on intracellular membranes
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric diester
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
glycoprotein-phosphatidylinositol phosphatidohydrolase
This enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure. It therefore cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors, but does so by hydrolysis, whereas glycosylphosphatidylinositol diacylglycerol-lyase (EC 4.6.1.14) does so by elimination. It acts on plasma membranes only after solubilization of the substrate with detergents or solvents, but it may act on intracellular membranes.
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CAS REGISTRY NUMBER
COMMENTARY
113756-14-2
-
127737-50-2
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
glycosylphosphatidylinositol-anchored placental alkaline phosphatase + H2O
?
-
-
-
-
?
glycosylphosphatidylinositol-anchored proteins
phosphatidic acid + variant membrane protein
-
GPI-PLD is highly specific for the GPI anchor
-
-
ir
glycosylphosphatidylinositol-membrane anchor of Cripto-1
soluble Cripto-1 + phosphatidic acid
-
-
-
-
ir
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
membrane-anchored form of urokinase plasminogen activator + H2O
soluble form of urokinase plasminogen activator
-
i.e. uPAR or CD 87
-
?
membrane-bound mucin binding protein + H2O
free mucin binding protein
-
-
-
?
myristate-labelled membrane form of variant surface glycoprotein from Trypanosoma brucei + H2O
?
-
-
-
-
?
phosphatidylinositol-glycan-anchor of membrane form of acetylcholinesterase + H2O
?
-
-
-
-
?
phosphatidylinositol-glycan-anchored membrane form of acetylcholinesterase + H2O
soluble acetylcholinesterase + phosphatidic acid
-
isolated from bovine erythrocyte membranes
-
?
Zn2+-glycerophosphocholine cholinephosphodiesterase, amphiphilic form + H2O
Zn2+-glycerophosphocholine cholinephosphodiesterase, hydrophilic form
glycosylphosphatidylinositol-anchored protein + H2O
?
-
GPI-PDL can influence the steady-state levels of glycosylphosphatidylinositol-anchored proteins by hydrolysing the anchor before and after its attachment to proteins
-
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
-
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
phospholipase D-type hydrolysis
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
-
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
phospholipase D-type hydrolysis
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
-
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
phospholipase D-type hydrolysis
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
-
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
phospholipase D-type hydrolysis
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
-
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
-
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
-
-
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
cleaves phosphodiester linkage to diacylglycerol
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
specific for glycosyl-phosphatidylinositol structure, i.e. the anchoring domain of cell surface proteins
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
phospholipase D-type hydrolysis
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
phospholipase D-type hydrolysis
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
-
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
specific for glycosyl-phosphatidylinositol structure, i.e. the anchoring domain of cell surface proteins
dimyristoylphosphatidic acid
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
phospholipase D-type hydrolysis
dimyristoylphosphatidic acid
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
-
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
specific for glycosyl-phosphatidylinositol structure, i.e. the anchoring domain of cell surface proteins
dimyristoylphosphatidic acid
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
phospholipase D-type hydrolysis
dimyristoylphosphatidic acid
?
membrane-bound carcinoembryonic antigen + H2O
?
-
cleavage enhances the metastatic potential in colorectal carcinoma cells
-
-
?
Zn2+-glycerophosphocholine cholinephosphodiesterase, amphiphilic form + H2O
Zn2+-glycerophosphocholine cholinephosphodiesterase, hydrophilic form
-
-
-
?
Zn2+-glycerophosphocholine cholinephosphodiesterase, amphiphilic form + H2O
Zn2+-glycerophosphocholine cholinephosphodiesterase, hydrophilic form
-
-
-
?
additional information
?
-
-
no substrate: phosphatidylethanolamine, phosphatidylcholine, phosphatidylinositol derived from HNO2-cleaved mfVSG, overview on substrate specificity
-
-
?
additional information
?
-
-
overexpression of enzyme is lethal to wild-type cells, possibly by catalysing the overproduction of enzyme-derived toxic substances
-
-
?
additional information
?
-
-
the cleavage of chiro-inositol-containing glycerophosphatidylinositols results in both L-chiro- and D-chiro-inositol-containing inositol-phosphoglycans
-
-
?
additional information
?
-
-
cleavage of glycosylphosphatidylinositol-anchor of membrane proteins
-
-
?
additional information
?
-
glycosylphosphatidyl-inositol-anchor cleavage of cell adhesion molecule (csA)
-
-
?
additional information
?
-
-
no substrate: phosphatidylethanolamine, phosphatidylcholine, phosphatidylinositol derived from HNO2-cleaved mfVSG, overview on substrate specificity
-
-
?
additional information
?
-
-
enzyme catalyzed cleavage of glycosylphosphatidylinositol anchor is a potential source of diacylglycerol production to activate protein kinase Calpha
-
-
?
additional information
?
-
-
GPI-PDL activities and their mRNA copies in patients with chronic myeloid leukemia are significantly lower than those in healthy adults. The decreased GPI-PLD expression may reduce the release of GPI-anchored CD55 and CD59 in leukemia cells and finally decrease complement mediated killing of these cells in chronic phase of chronic myeloid leukemia
-
-
?
additional information
?
-
-
GPI-PLD may play a role in islet amyloid formation in type 2 diabetes
-
-
?
additional information
?
-
-
involvement of endogenous GPI-PDI in spontaneous elevated release of carcinoembryonic antigen from human colon cancer cells
-
-
?
additional information
?
-
-
the enzyme plays an active role in lipoprotein metabolism and may contribute to the dyslipidemia of insulin resistant patients
-
-
?
additional information
?
-
-
patients with non-alcoholic fatty liver disease have elevated serum levels and hepatic expression of glycosylphosphatidylinositol-specific phospholipase D. The enzyme may play a role in the pathogenesis of non-alcoholic fatty liver disease and/or its metabolic features
-
-
?
additional information
?
-
-
cleavage of GPI-membrane anchor of carcinoembryonic antigen enhances the metastatic potential in colorectal carcinoma cells
-
-
?
additional information
?
-
cleavage of the glycan-phosphatidylinositol linkage of GPI-anchored proteins
-
-
?
additional information
?
-
-
downregulation of enzyme could play an important role in the control of proinflammatory responses
-
-
?
additional information
?
-
-
glucose and insulin regulate enzyme mRNA levels
-
-
?
additional information
?
-
-
the enzyme is involved in the process of bone formation during mouse embryogenesis
-
-
?
additional information
?
-
-
the enzyme plays role in triglyceride metabolism, affects serum triglyceride levels by altering catabolism of triglyceride-rich lipoproteins. Overexpression of hepatic GPI-PLD induces an increase in fasting and postprandial triglyceride secondary to a decrease in catabolism of triglyceride-rich lipoproteins. GPI-PLD may play a role in the dyslipidemia of the metabolic syndrome
-
-
?
additional information
?
-
-
little or no activity towards phosphatidylinositol or phosphatidylcholine
-
-
?
additional information
?
-
-
little or no activity towards phosphatidylinositol or phosphatidylcholine
-
-
?
additional information
?
-
-
glucose and insulin regulate enzyme mRNA levels
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
glycosylphosphatidylinositol-anchored protein + H2O
?
-
GPI-PDL can influence the steady-state levels of glycosylphosphatidylinositol-anchored proteins by hydrolysing the anchor before and after its attachment to proteins
-
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
membrane-bound carcinoembryonic antigen + H2O
?
-
cleavage enhances the metastatic potential in colorectal carcinoma cells
-
-
?
phosphatidylinositol-glycan-anchored membrane form of acetylcholinesterase + H2O
soluble acetylcholinesterase + phosphatidic acid
-
isolated from bovine erythrocyte membranes
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
-
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
-
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
-
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
-
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
-
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
-
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
-
-
?
membrane form of variant-surface-glycoprotein + H2O
phosphatidic acid + variant-surface-glycoprotein inositol
-
-
-
?
additional information
?
-
-
overexpression of enzyme is lethal to wild-type cells, possibly by catalysing the overproduction of enzyme-derived toxic substances
-
-
?
additional information
?
-
-
enzyme catalyzed cleavage of glycosylphosphatidylinositol anchor is a potential source of diacylglycerol production to activate protein kinase Calpha
-
-
?
additional information
?
-
-
GPI-PDL activities and their mRNA copies in patients with chronic myeloid leukemia are significantly lower than those in healthy adults. The decreased GPI-PLD expression may reduce the release of GPI-anchored CD55 and CD59 in leukemia cells and finally decrease complement mediated killing of these cells in chronic phase of chronic myeloid leukemia
-
-
?
additional information
?
-
-
GPI-PLD may play a role in islet amyloid formation in type 2 diabetes
-
-
?
additional information
?
-
-
involvement of endogenous GPI-PDI in spontaneous elevated release of carcinoembryonic antigen from human colon cancer cells
-
-
?
additional information
?
-
-
the enzyme plays an active role in lipoprotein metabolism and may contribute to the dyslipidemia of insulin resistant patients
-
-
?
additional information
?
-
-
patients with non-alcoholic fatty liver disease have elevated serum levels and hepatic expression of glycosylphosphatidylinositol-specific phospholipase D. The enzyme may play a role in the pathogenesis of non-alcoholic fatty liver disease and/or its metabolic features
-
-
?
additional information
?
-
-
downregulation of enzyme could play an important role in the control of proinflammatory responses
-
-
?
additional information
?
-
-
glucose and insulin regulate enzyme mRNA levels
-
-
?
additional information
?
-
-
the enzyme is involved in the process of bone formation during mouse embryogenesis
-
-
?
additional information
?
-
-
the enzyme plays role in triglyceride metabolism, affects serum triglyceride levels by altering catabolism of triglyceride-rich lipoproteins. Overexpression of hepatic GPI-PLD induces an increase in fasting and postprandial triglyceride secondary to a decrease in catabolism of triglyceride-rich lipoproteins. GPI-PLD may play a role in the dyslipidemia of the metabolic syndrome
-
-
?
additional information
?
-
-
glucose and insulin regulate enzyme mRNA levels
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
Ca2+
-
large increase of activity between 0.0001 and 0.01 mM, slight decrease above 1 mM
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Ca2+
-
slight decrease of activity above 1 mM, activation at 0.0001-0.01 mM
additional information
-
no inhibition by leupeptin; no inhibition by trifluoperazine
-
additional information
-
no inhibition by leupeptin; no inhibition by PMSF
-
additional information
-
no inhibition by leupeptin; no inhibition by PMSF
-
additional information
-
no inhibition by 1,7-phenanthroline or 2,2'-dipyridyl
-
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
monoacylglycerol
-
stimulates in a size-dependent manner, maximal enhancement with monodecanoylglycerol
n-butanol
-
activation, at pH 5, membrane form of variant-surface-glycoprotein as substrate
additional information
-
higher activity at low ionic strength, increasing amounts of NaCl, KCl, Na2SO4 or sodium phosphate decrease activity
-
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma, Bronchiolo-Alveolar
Down-regulation of glycosylphosphatidylinositol-specific phospholipase D induced by lipopolysaccharide and oxidative stress in the murine monocyte- macrophage cell line RAW 264.7.
Alzheimer Disease
Phosphatidylinositol-glycan-phospholipase D is involved in neurodegeneration in prion disease.
Aneurysm
Discovery of a novel circulating biomarker in patients with abdominal aortic aneurysm: a pilot study using a proteomic approach.
Aneurysm
Plasma glycosylphosphatidylinositol phospholipase D (GPI-PLD) and abdominal aortic aneurysm.
Aortic Aneurysm, Abdominal
Plasma glycosylphosphatidylinositol phospholipase D (GPI-PLD) and abdominal aortic aneurysm.
Atherosclerosis
Glycosylphosphatidylinositol-specific phospholipase D is expressed by macrophages in human atherosclerosis and colocalizes with oxidation epitopes.
Carcinoma, Hepatocellular
Glycosylphosphatidylinositol-specific phospholipase d in nonalcoholic Fatty liver disease: a preliminary study.
Carcinoma, Hepatocellular
Identification of glycoinositol phospholipids in rat liver by reductive radiomethylation of amines but not in H4IIE hepatoma cells or isolated hepatocytes by biosynthetic labeling with glucosamine.
Carcinoma, Hepatocellular
Important roles of glycosylphosphatidylinositol (GPI)-specific phospholipase D and some GPI-anchored proteins in the pathogenesis of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Regulation of glycosylphosphatidylinositol-anchored proteins and GPI-phospholipase D in a c-Myc transgenic mouse model of hepatocellular carcinoma and human HCC.
Carcinoma, Hepatocellular
[Effect of overexpression of glycosylphosphatidylinositol-specific phospholipase D on biological character of hepatocellular carcinoma cell line HepG2.]
Carcinoma, Hepatocellular
[GPI-PLD inhibits the growth of hepatoma cells by down-regulation of PI3K-Akt signaling pathway].
Carcinoma, Squamous Cell
GPI-specific phospholipase D mRNA expression in tumor cells of different malignancy.
Cholestasis
Solubilization of liver alkaline phosphatase isoenzyme during cholestasis in dogs.
Colonic Neoplasms
Evidence for CEA release from human colon cancer cells by an endogenous GPI-PLD enzyme.
Colonic Neoplasms
Regulation of carcinoembryonic antigen release from colorectal cancer cells.
Colorectal Neoplasms
Cleavage of carcinoembryonic antigen induces metastatic potential in colorectal carcinoma.
Creutzfeldt-Jakob Syndrome
Phosphatidylinositol-glycan-phospholipase D is involved in neurodegeneration in prion disease.
Diabetes Mellitus, Type 1
Genetic regulation of mouse glycosylphosphatidylinositol-phospholipase D.
Diabetes Mellitus, Type 1
Increased expression of GPI-specific phospholipase D in mouse models of type 1 diabetes.
Diabetes Mellitus, Type 1
The Clinical Significance of Glycoprotein Phospholipase D Levels in Distinguishing Early Stage Latent Autoimmune Diabetes in Adults and Type 2 Diabetes.
Diabetes Mellitus, Type 2
Glycosylphosphatidylinositol-specific phospholipase D immunoreactivity is present in islet amyloid in type 2 diabetes.
Diabetes Mellitus, Type 2
Impact of glycosylphosphatidylinositol-specific phospholipase D on hepatic diacylglycerol accumulation, steatosis, and insulin resistance in diet-induced obesity.
Diabetes Mellitus, Type 2
MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: the KORA F4 study.
Diabetes Mellitus, Type 2
The Clinical Significance of Glycoprotein Phospholipase D Levels in Distinguishing Early Stage Latent Autoimmune Diabetes in Adults and Type 2 Diabetes.
Epilepsy
Genetic Association of Epilepsy and Anti-Epileptic Drugs Treatment in Jordanian Patients.
Epilepsy, Generalized
Genetic Association of Epilepsy and Anti-Epileptic Drugs Treatment in Jordanian Patients.
Fatty Liver
Regulation of glycosylphosphatidylinositol-anchored proteins and GPI-phospholipase D in a c-Myc transgenic mouse model of hepatocellular carcinoma and human HCC.
Glucose Intolerance
Impact of glycosylphosphatidylinositol-specific phospholipase D on hepatic diacylglycerol accumulation, steatosis, and insulin resistance in diet-induced obesity.
Hyperglycemia
Increased expression of GPI-specific phospholipase D in mouse models of type 1 diabetes.
Insulin Resistance
Glucose and insulin regulate glycosylphosphatidylinositol-specific phospholipase D expression in islet beta cells.
Insulin Resistance
Glycosylphosphatidylinositol-specific phospholipase D improves glucose tolerance.
Insulin Resistance
Glycosylphosphatidylinositol-specific phospholipase d in nonalcoholic Fatty liver disease: a preliminary study.
Insulin Resistance
Impact of glycosylphosphatidylinositol-specific phospholipase D on hepatic diacylglycerol accumulation, steatosis, and insulin resistance in diet-induced obesity.
Insulin Resistance
Insulin resistance is associated with increased serum levels of glycosylphosphatidylinositol-specific phospholipase D.
Insulin Resistance
Plasma glycosylphosphatidylinositol-specific phospholipase D predicts the change in insulin sensitivity in response to a low-fat but not a low-carbohydrate diet in obese women.
Insulin Resistance
Serum glypican4 and glycosylphosphatidylinositol-specific phospholipase D levels are associated with adipose tissue insulin resistance in obese subjects with different glucose metabolism status.
Insulin Resistance
Upregulated Phospholipase D Activity Towards Glycosylphosphatidylinositol-Anchored Proteins in Micelle-Like Serum Complexes in Diabetic/Obese Rats and Humans.
Insulinoma
Glucose and insulin regulate glycosylphosphatidylinositol-specific phospholipase D expression in islet beta cells.
Insulinoma
Glycosylphosphatidylinositol-specific phospholipase D improves glucose tolerance.
Insulinoma
Regulation of glycosylphosphatidylinositol-specific phospholipase D secretion from beta TC3 cells.
Latent Autoimmune Diabetes in Adults
The Clinical Significance of Glycoprotein Phospholipase D Levels in Distinguishing Early Stage Latent Autoimmune Diabetes in Adults and Type 2 Diabetes.
Leukemia
Effect of glycosylphosphatidylinositol specific phospholipase D gene expression levels on complement mediated killing of leukemic cells in patients with chronic myeloid leukemia.
Leukemia
[Expression and activity of glycosylphosphatidilinoditol-specific phospholipase d mRNA in bone marrow mononuclear cells isolated from patient with acute myeloid leukemia and their significance]
Leukemia
[GPI-PLD gene exon14 polymorphisms of leucocyte in peripheral blood from healthy persons and leukemia patients]
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Effect of glycosylphosphatidylinositol specific phospholipase D gene expression levels on complement mediated killing of leukemic cells in patients with chronic myeloid leukemia.
Leukemia, Myeloid
[Effect of GPI-PLD on adhesion function of bone marrow mononuclear cell from patients with myeloid leukemia and its mechanism]
Leukemia, Myeloid, Acute
[Expression and activity of glycosylphosphatidilinoditol-specific phospholipase d mRNA in bone marrow mononuclear cells isolated from patient with acute myeloid leukemia and their significance]
Leukemia, Myeloid, Acute
[GPI-PLD gene exon14 polymorphisms of leucocyte in peripheral blood from healthy persons and leukemia patients]
Liver Diseases
Glycosylphosphatidylinositol-specific phospholipase d in nonalcoholic Fatty liver disease: a preliminary study.
Liver Diseases
Impact of glycosylphosphatidylinositol-specific phospholipase D on hepatic diacylglycerol accumulation, steatosis, and insulin resistance in diet-induced obesity.
Liver Diseases
Regulation of glycosylphosphatidylinositol-anchored proteins and GPI-phospholipase D in a c-Myc transgenic mouse model of hepatocellular carcinoma and human HCC.
Lymphoma
Saponin-induced release of cell-surface-anchored Thy-1 by serum glycosylphosphatidylinositol-specific phospholipase D.
Metabolic Syndrome
Impact of glycosylphosphatidylinositol-specific phospholipase D on hepatic diacylglycerol accumulation, steatosis, and insulin resistance in diet-induced obesity.
Neoplasm Metastasis
Role of glycosylphosphatidylinositol-specific phospholipase D in the homing of umbilical cord blood, mobilized peripheral blood and bone marrow-derived hematopoietic stem/progenitor cells.
Neoplasms
Activated human neutrophils rapidly release the chemotactically active D2D3 form of the urokinase-type plasminogen activator receptor (uPAR/CD87).
Neoplasms
Biosynthesis of carcinoembryonic antigen (CEA) gene family members expressed in human tumor cell lines: evidence for cleavage of the glycosyl phosphatidyl inositol (GPI) anchor by GPI-PLC and GPI-PLD.
Neoplasms
Cellular glycosylphosphatidylinositol-specific phospholipase D regulates urokinase receptor shedding and cell surface expression.
Neoplasms
Down-regulation of glycosylphosphatidylinositol-specific phospholipase D induced by lipopolysaccharide and oxidative stress in the murine monocyte- macrophage cell line RAW 264.7.
Neoplasms
Glycosylphosphatidylinositol-specific phospholipase D is expressed by macrophages in human atherosclerosis and colocalizes with oxidation epitopes.
Neoplasms
GPI-specific phospholipase D mRNA expression in tumor cells of different malignancy.
Neoplasms
How Glycosylphosphatidylinositol-phospholipase D acts in homing of hematopoietic stem/progenitor cells?
Neoplasms
Inhibition of glycosylphosphatidylinositol (GPI) phospholipase D by suramin-like compounds.
Neoplasms
Role of glycosylphosphatidylinositol-specific phospholipase D in the homing of umbilical cord blood, mobilized peripheral blood and bone marrow-derived hematopoietic stem/progenitor cells.
Neoplasms
[GPI-PLD inhibits the growth of hepatoma cells by down-regulation of PI3K-Akt signaling pathway].
Neuroblastoma
Uptake and intracellular stability of glycosylphosphatidylinositol-specific phospholipase D in neuroblastoma cells.
Neurofibromatoses
Immunolocalization of a glycosylphosphatidylinositol-specific phospholipase D in mast cells found in normal tissue and neurofibromatosis lesions.
Non-alcoholic Fatty Liver Disease
Glycosylphosphatidylinositol-specific phospholipase d in nonalcoholic Fatty liver disease: a preliminary study.
Non-alcoholic Fatty Liver Disease
Impact of glycosylphosphatidylinositol-specific phospholipase D on hepatic diacylglycerol accumulation, steatosis, and insulin resistance in diet-induced obesity.
Obesity
Impact of glycosylphosphatidylinositol-specific phospholipase D on hepatic diacylglycerol accumulation, steatosis, and insulin resistance in diet-induced obesity.
Obesity
Upregulated Phospholipase D Activity Towards Glycosylphosphatidylinositol-Anchored Proteins in Micelle-Like Serum Complexes in Diabetic/Obese Rats and Humans.
Ovarian Neoplasms
GPI-specific phospholipase D mRNA expression in tumor cells of different malignancy.
Pre-Eclampsia
Placental GPI-PLD is of maternal origin and its GPI substrate is absent from placentae of pregnancies associated with pre-eclampsia.
Prediabetic State
MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: the KORA F4 study.
Prion Diseases
Phosphatidylinositol-glycan-phospholipase D is involved in neurodegeneration in prion disease.
Sepsis
Glycosylphosphatidylinositol-specific phospholipase D in blood serum: is the liver the only source of the enzyme?
Shock, Septic
Glycosylphosphatidylinositol-specific phospholipase D in blood serum: is the liver the only source of the enzyme?
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0001
phosphatidylinositol-glycan-anchor of membrane form of acetylcholinesterase
-
37°C, pH 7.4
-
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6
-
higher activity at low ionic strength, increasing amounts of NaCl, KCl, Na2SO4 or sodium phosphate decrease activity
7.4
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5 - 7
-
about 60% of maximal activity at pH 5 and about half-maximal activity at pH 7, no activity above pH 8.5
5 - 8
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
expression during embryonic ossification. GPI-PLD is observed during both intramembraneous and endochondral ossification and localized predominantly to the extracellular matrix of chondrocytes and to primary trabecular of the skeleton
brenda
-
localized predominantly to the extracellulat matrix of chondrocytes and to primary trabeculae of the skeleton
brenda
-
SW620, SW837, Colo201, Colo320 and SW1736
brenda
-
the serum GPI-PLD activities, the GPI-PLD protein expression levels, and the protein and mRNA levels of GPI-PLD in hepatocellular carcinoma are decreased by 40%, 60%, and 56%, respectively
brenda
-
GPI-PDL activities and their mRNA copies in patients with chronic myeloid leukemia are significantly lower than those in healthy adults
brenda
-
localized predominantly to the extracellulat matrix of chondrocytes and to primary trabeculae of the skeleton
brenda
additional information
-
GPI-PLD is expressed in nearly all tissues and cells types, but the liver has the highest level of GPI-PLD expression and is the primary source of circulating GPI-PLD. GPI-PLD is a minor high-density lipoprotein-associated protein. It is elevated in patients with insulin resistance or high triglycerides
brenda
-
plasma enzyme levels are significantly lower in patients with ruptured compared nonruptured abdominal aortic aneurysm which is a result of hemodilution due to hemorrhage in patients with ruptured abdominal aortic aneurysm. The plasma enzyme levels are similar in patients with nonruptured abdominal aortic aneurysm compared to the controls without aneurysm
brenda
-
hepatic GPI-PLD messenger RNA and serum GPI-PLD levels are increased in patients with nonalcoholic fatty liver disease
brenda
expression is mouse strain-dependent and shows hormonal regulation. mRNA level is higher in 4-week old animals compared to older animals, and the GPI-PLD mRNA level increases in mice that developed insulin dependent type 1 diabetes spontaneously
brenda
-
the baseline level of plasma GPI-PLD in the cohort of obese women on low-carbohydrate and low-fat weight loss diets is nearly twice that of a cohort with nonalcoholic fatty liver disease, but similar to that of a cohort with type 2 diabetes mellitus and low HDL
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
murine pancreatic enzyme is recombinantly expressed in Hela cells
brenda
-
murine pancreatic enzyme is recombinantly expressed in Hela cells
brenda
-
murine pancreatic enzyme is recombinantly expressed in Hela cells
brenda
additional information
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
metabolism
physiological function
malfunction
-
GPI-PLD is elevated in patients with insulin resistance or high triglycerides, and in patients with nonalcoholic fatty liver disease, overview
malfunction
-
plasma enzyme levels are significantly lower in patients with ruptured compared nonruptured abdominal aortic aneurysm which is a result of hemodilution due to hemorrhage in patients with ruptured abdominal aortic aneurysm. The plasma enzyme levels are similar in patients with nonruptured abdominal aortic aneurysm compared to the controls without aneurysm
physiological function
-
the enzyme may participate in regulating inflammation in atherosclerosis
physiological function
GPI-PLD directly regulates intracellular diacylglycerol content in primary hepatocytes. Serum GPI-PLD levels are strongly and independently associated with serum alanine transaminase and triglyceride levels in male subjects with metabolic syndrome
physiological function
mice lacking GPI-PLD exhibit glucose intolerance and hepatic steatosis under high-fat and high-sucrose diet. Diacylglycerol content is significantly decreased, and protein kinase PKCepsilon activity is suppressed in the livers of knockout mice
physiological function
serum GPI-PLD level is strongly and independently associated with serum alanine transaminase and triglyceride levels in human male subjects
Show AA Sequence and Transmembrane Helices (664 entries)
Please use the AA Sequence and Transmembrane Helices Search for a specific query.
Please use the AA Sequence and Transmembrane Helices Search for a specific query.
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
glycoprotein
-
different oligosaccharide processing of enzyme after expression in mammalian CHO cells and insect H5 cells affecting immunoreactive and enzymatic properties
phosphoprotein
-
wild-type enzyme and mutant enzymes H81N, H98N, H125N, H133N and H158N are phosphorylated
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
signal-peptide deficient form of enzyme is catalytically active and intracellularly localized, GPI-anchored form of enzyme is catalytically active and cells release endogenous GPI-anchored alkaline phosphatase
additional information
C-terminal deletion of 2-5 amino acids results in loss of about 70% of enzymic activity, deletion of more than 5 amino acids results in complete loss of activity, Y811 may be crucial for activity
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
stable over a range of 0.01-0.1% detergent, ionic detergents such as SDS are inhibitory, and bicarbonate buffer is inhibitory
stable over a range of 0.01-0.1% detergent, ionic detergents such as SDS are inhibitory, and bicarbonate buffer is inhibitory
-
stable over a range of 0.01-0.1% detergent, ionic detergents such as SDS are inhibitory, and bicarbonate buffer is inhibitory
-
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
overexpression of GPI-PLD in the insulinoma cell line betaTC6f7 enhances glucose-stimulated insulin secretion 4fold, but does not affect the preproinsulin mRNA levels. Overexpressing GPI-PLD using adenovirus-mediated gene transfer in C57BL/6 mice, associated with a decrease in fasting glucose as well as an improvement in glucose tolerance
-
overview
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
hepatic GPI-PLD messenger RNA and serum GPI-PLD levels are increased in patients with nonalcoholic fatty liver disease
-
the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice
the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice
the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice
the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
diagnostics
-
the enzyme might be a diagnostic predictive marker for abdominal aortic aneurysm
medicine
additional information
-
GPI-PLD predicts the change in insulin resistance in subjects randomized to the low-fat diet, but not in response to those randomized to the very low carbohydrate diet
medicine
-
patients with liver disease have lower activites, those with renal disease have higher activities than healthy controls
medicine
-
enzyme activity is over 75% reduced in systemic inflammatory response syndrome, downregulation of enzyme could play an important role in the control of proinflammatory responses
medicine
-
enzyme may be involved in generation of circulating prognostic markers in cancer
medicine
-
serum enzyme activity is positively correlated with inflammatory markers and counts of monocytes and stab cells
medicine
-
serum enzyme activity is positively correlated with inflammatory markers and counts of monocytes and stab cells
medicine
-
baseline GPI-PLD levels correlate with the change in insulin sensitivity in response to the low-fat diet, whereas baseline insulin sensitivity correlates with the change in insulin sensitivity in response to the lowcarbohydrate diet, plasma GPI-PLD may serve as a clinical tool to determine the effect of a low-fat diet on insulin sensitivity
medicine
in a c-Myc transgenic disease model of liver cancer, serum GPI-PLD activity is increased 4fold in transgenic mice, while its tissue activity is reduced by 70%
medicine
in samples from steatohepatitis and hepatocellular carcinoma patients, serum GPI-PLD activity is increased 4fold, while its tissue activity is reduced by 60%. c-Myc influences GPI-AP signaling transcriptionally and posttranslationally and represses GPI-AP anti-proliferative signaling in tumors
medicine
the expression of GPI-PLD is dramatically down-regulated in both the brain and cerebrospinal fluids of Creutzfeldt-Jakob disease patients, while no differences in expression are observed in either the brains or cerebrospinal fluids specimens from Alzheimer's disease patients
medicine
the expression of GPI-PLD is dramatically down-regulated in the brains of scrapie-infected mice, especially in the caveolin-enriched membrane fractions. The decrease in GPI-PLD expression levels begins at the same time that prion proteins begin to accumulate in the infected brains
medicine
the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice
medicine
the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice
medicine
the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Malik, A.S.; Low, M.G.
Conversion of human placental alkaline phosphatase from a high Mr form to a low Mr form during butanol extraction. An investigation of the role of endogenous phosphoinositide-specific phospholipases
Biochem. J.
240
519-527
1986
Homo sapiens
brenda
Low, M.G.; Prasad, A.R.S.
A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma
Proc. Natl. Acad. Sci. USA
85
980-984
1988
Bos taurus, Canis lupus familiaris, Gallus gallus, Oryctolagus cuniculus, Equus caballus, Homo sapiens, Rattus norvegicus
brenda
Stieger, S.; Diem, S.; Jakob, A.; Brodbeck, U.
Enzymatic properties of phosphatidylinositol-glycan-specific phospholipase C from rat liver and phosphatidylinositol-glycan-specific phospholipase D from rat serum [published erratum appears in Eur J Biochem 1991 Sep 15;200(3):812]
Eur. J. Biochem.
197
67-73
1991
Rattus norvegicus
brenda
Bowen, R.F.; Raikwar, N.S.; Olson, L.K.; Deeg, M.A.
Glucose and insulin regulate glycosylphosphatidylinositol-specific phospholipase D expression in islet beta cells
Metabolism
50
1489-1492
2001
Mus musculus, Rattus norvegicus
brenda
Deeg, M.A.; Davitz, M.A.
Glycosylphosphatidylinositol-phospholipase D: a tool for glycosylphosphatidylinositol structural analysis
Methods Enzymol.
250
630-640
1995
Bos taurus, Homo sapiens
brenda
Du, X.; Low, M.G.
Down-regulation of glycosylphosphatidylinositol-specific phospholipase D induced by lipopolysaccharide and oxidative stress in the murine monocyte-macrophage cell line RAW 264.7
Infect. Immun.
69
3214-3223
2001
Mus musculus
brenda
Du, X.; Cai, J.; Zhou, J.Z.; Stevens, V.L.; Low, M.G.
Tolerance of glycosylphosphatidylinositol (GPI)-specific phospholipase D overexpression by Chinese hamster ovary cell mutants with aberrant GPI biosynthesis
Biochem. J.
361
113-118
2002
Bos taurus
brenda
Hari, T.; Kunze, H.; Bohn, E.; Brodbeck, U.; Butikofer, P.
Subcellular distribution of glycosylphosphatidylinositol-specific phospholipase D in rat liver
Biochem. J.
320
315-319
1996
Rattus norvegicus
brenda
Hari, T.; Buetikofer, P.; N.Wiesmann, U.; Brodbeck, U.
Uptake and intracellular stability of glycosylphosphatidylinositol-specific phospholipase D in neuroblastoma cells
Biochim. Biophys. Acta
1355
293-302
1997
Bos taurus
brenda
Kueng, M.; Buetikofer, P.; Brodbeck, U.; Stadelmann, B.
Expression of intracellular and GPI-anchored forms of GPI-specific phospholipase D in COS-1 cells
Biochim. Biophys. Acta
1357
329-338
1997
Bos taurus (P80109)
brenda
Lee, J.Y.; Kim, M.R.; Sok, D.E.
Enzymatic release of Zn2+-glycerophosphocholine cholinephosphodiesterase from brain membranes by glycosylphosphatidylinositol-specific phospholipases and its regulation
Neurochem. Res.
23
899-905
1998
Bos taurus
brenda
Lee, J.Y.; Lee, H.J.; Kim, M.R.; Myung, P.K.; Sok, D.E.
Regulation of brain glycosylphosphatidylinositol-specific phospholipase D by natural amphiphiles
Neurochem. Res.
24
1577-1583
1999
Bos taurus
brenda
Li, J.Y.; Hollfelder, K.; Huang, K.S.; Low, M.G.
Structural features of GPI-specific phospholipase D revealed by proteolytic fragmentation and Ca2+ binding studies
J. Biol. Chem.
269
28963-28971
1994
Bos taurus
brenda
Maguire, G.A.; Gossner, A.
Glycosyl phosphatidyl inositol phospholipase D activity in human serum
Ann. Clin. Biochem.
32
74-78
1995
Homo sapiens
brenda
Rhode, H.; Schulze, M.; Cumme, G.A.; Gohlert, A.; Blume, E.; Bublitz, R.; Schilling, K.; Horn, A.
Glycosylphosphatidylinositol-specific phospholipase D of human serum--activity modulation by naturally occurring amphiphiles
Biol. Chem.
381
471-485
2000
Homo sapiens
brenda
Rhode, H.; Lopatta, E.; Schulze, M.; Pascual, C.; Schulze, H.P.; Schubert, K.; Schubert, H.; Reinhart, K.; Horn, A.
Glycosylphosphatidylinositol-specific phospholipase D in blood serum: is the liver the only source of the enzyme?
Clin. Chim. Acta
281
127-145
1999
Homo sapiens, Rattus norvegicus
brenda
Schofield, J.N.; Stephens, J.W.; Hurel, S.J.; Bell, K.M.; deSouza, J.B.; Rademacher, T.W.
Insulin reduces serum glycosylphosphatidylinositol phospholipase D levels in human type I diabetic patients and streptozotocin diabetic rats
Mol. Genet. Metab.
75
154-161
2002
Homo sapiens, Rattus norvegicus (Q8R2H5)
brenda
Slomiany, A.; Nishikawa, H.; Slomiany, B.L.
Screening and modulation of extracellular signals by mucous barrier. Serum glycosylphosphatidylinositol phospholipase D (GPI-PLD) releases protective mucous barrier from oral mucosa
J. Physiol. Pharmacol.
53
21-38
2002
Rattus norvegicus
brenda
Stadelmann, B.; Butikofer, P.; Konig, A.; Brodbeck, U.
The C-terminus of glycosylphosphatidylinositol-specific phospholipase D is essential for biological activity
Biochim. Biophys. Acta
1355
107-113
1997
Bos taurus (P80109)
brenda
Tsujioka, H.; Takami, N.; Misumi, Y.; Ikehara, Y.
Intracellular cleavage of glycosylphosphatidylinositol by phospholipase D induces activation of protein kinase Calpha
Biochem. J.
342
449-455
1999
Homo sapiens
brenda
Tsujioka, H.; Misumi, Y.; Takami, N.; Ikehara, Y.; Tujioka, H.
Posttranslational modification of glycosylphosphatidylinositol (GPI)-specific phospholipase D and its activity in cleavage of GPI anchors
Biochem. Biophys. Res. Commun.
251
737-743
1998
Homo sapiens
brenda
Wilhelm, O.G.; Wilhelm, S.; Escott, G.M.; Lutz, V.; Magdolen, V.; Schmitt, M.; Rifkin, D.B.; Wilson, E.L.; Graeff, H.; Brunner, G.
Cellular glycosylphosphatidylinositol-specific phospholipase D regulates urokinase receptor shedding and cell surface expression
J. Cell. Physiol.
180
225-235
1999
Homo sapiens
brenda
LeBoeuf, R.C.; Caldwell, M.; Guo, Y.; Metz, C.; Davitz, M.A.; Olson, L.K.; Deeg, M.A.
Mouse glycosylphosphatidylinositol-specific phospholipase D (Gpld1) characterization
Mamm. Genome
9
710-714
1998
Mus musculus (O70362), Mus musculus
brenda
Raikwar, N.S.; Cho, W.K.; Bowen, R.F.; Deeg, M.A.
Glycosylphosphatidylinositol-specific phospholipase D influences triglyceride-rich lipoprotein metabolism
Am. J. Physiol.
290
E463-470
2006
Mus musculus
brenda
Yamamoto, Y.; Hirakawa, E.; Mori, S.; Hamada, Y.; Kawaguchi, N.; Matsuura, N.
Cleavage of carcinoembryonic antigen induces metastatic potential in colorectal carcinoma
Biochem. Biophys. Res. Commun.
333
223-229
2005
Homo sapiens
brenda
Mann, K.J.; Hepworth, M.R.; Raikwar, N.S.; Deeg, M.A.; Sevlever, D.
Effect of glycosylphosphatidylinositol (GPI)-phospholipase D overexpression on GPI metabolism
Biochem. J.
378
641-648
2004
Mus musculus
brenda
Raikwar, N.S.; Bowen, R.F.; Deeg, M.A.
Mutating His29, His125, His133 or His158 abolishes glycosylphosphatidylinositol-specific phospholipase D catalytic activity
Biochem. J.
391
285-289
2005
Mus musculus
brenda
Flores-Borja, F.; Kieszkievicz, J.; Church, V.; Francis-West, P.H.; Schofield, J.; Rademacher, T.W.; Lund, T.
Genetic regulation of mouse glycosylphosphatidylinositol-phospholipase D
Biochimie
86
275-282
2004
Mus musculus (Q8R432), Mus musculus
brenda
Gregory, P.; Kraemer, E.; Zurcher, G.; Gentinetta, R.; Rohrbach, V.; Brodbeck, U.; Andres, A.C.; Ziemiecki, A.; Butikofer, P.
GPI-specific phospholipase D (GPI-PLD) is expressed during mouse development and is localized to the extracellular matrix of the developing mouse skeleton
Bone
37
139-147
2005
Mus musculus
brenda
Naghibalhossaini, F.; Ebadi, P.
Evidence for CEA release from human colon cancer cells by an endogenous GPI-PLD enzyme
Cancer Lett.
234
158-167
2006
Homo sapiens
brenda
Jian-Hua, T.; Xiao-Jie, Z.; Yi-Dan, W.; Wen-Kai, L.; Wang-Jiao, H.; Cheng-Hong, W.; Gui-Yuan, L.
Effect of glycosylphosphatidylinositol specific phospholipase D gene expression levels on complement mediated killing of leukemic cells in patients with chronic myeloid leukemia
Clin. Chim. Acta
359
115-124
2005
Homo sapiens
brenda
Larson, D.M.; Kennedy, M.A.; Bowen, R.F.; Verchere, C.B.; Deeg, M.A.
Glycosylphosphatidylinositol-specific phospholipase D immunoreactivity is present in islet amyloid in type 2 diabetes
J. Pathol.
203
961-967
2004
Homo sapiens
brenda
Kurtz, T.A.; Fineberg, N.S.; Considine, R.V.; Deeg, M.A.
Insulin resistance is associated with increased serum levels of glycosylphosphatidylinositol-specific phospholipase D
Metabolism
53
138-139
2004
Homo sapiens
brenda
Bonilla, J.B.; Cid, M.B.; Contreras, F.X.; Goni, F.M.; Martin-Lomas, M.
Phospholipase cleavage of D- and L-chiro-glycosylphosphoinositides asymmetrically incorporated into liposomal membranes
Chem. Eur. J.
12
1513-1528
2006
Bos taurus
brenda
Chalasani, N.; Vuppalanchi, R.; Raikwar, N.S.; Deeg, M.A.
Glycosylphosphatidylinositol-specific phospholipase D in non-alcoholic fatty liver disease: a preliminary study
J. Clin. Endocrinol. Metab.
91
2279-2285
2006
Homo sapiens
brenda
Yoshida, M.; Sakuragi, N.; Kondo, K.; Tanesaka, E.
Cleavage with phospholipase of the lipid anchor in the cell adhesion molecule, csA, from Dictyostelium discoideum
Comp. Biochem. Physiol. B
143B
138-144
2006
Bos taurus (P80109)
-
brenda
Watanabe, K.; Bianco, C.; Strizzi, L.; Hamada, S.; Mancino, M.; Bailly, V.; Mo, W.; Wen, D.; Miatkowski, K.; Gonzales, M.; Sanicola, M.; Seno, M.; Salomon, D.S.
Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration
J. Biol. Chem.
282
31643-31655
2007
Homo sapiens
brenda
Elortza, F.; Mohammed, S.; Bunkenborg, J.; Foster, L.J.; Nuehse, T.S.; Brodbeck, U.; Peck, S.C.; Jensen, O.N.
Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment
J. Proteome Res.
5
935-943
2006
Bos taurus
brenda
Song, K.; Sun, X.; Wang, J.; Zhou, S.; Zeng, H.; Chen, F.
Role of glycosylphosphatidylinositol-specific phospholipase D in the homing of umbilical cord blood, mobilized peripheral blood and bone marrow-derived hematopoietic stem/progenitor cells
Leuk. Res.
31
1701-1707
2007
Homo sapiens (P80108)
brenda
Song, K.; Sun, X.; Wang, J.; Chen, F.
How Glycosylphosphatidylinositol-phospholipase D acts in homing of hematopoietic stem/progenitor cells?
Med. Hypotheses
69
660-665
2007
Homo sapiens
brenda
Deeg, M.A.; Raikwar, N.S.; Johnson, C.; Williams, C.D.
Statin therapy reduces serum levels of glycosylphosphatidylinositol-specific phospholipase D
Transl. Res.
150
153-157
2007
Homo sapiens
brenda
Jian-Hua, T.; Wang-Jiao, H.; He, H.; Chao-Chao, T.; Qiong, D.; Kai-Jia, W.; Xian-Yu, Y.; Xu-Jin, Z.
Important roles of glycosylphosphatidylinositol (GPI)-specific phospholipase D and some GPI-anchored proteins in the pathogenesis of hepatocellular carcinoma
Clin. Biochem.
42
400-407
2009
Homo sapiens
brenda
Gray, D.L.; OBrien, K.D.; DAlessio, D.A.; Brehm, B.J.; Deeg, M.A.
Plasma glycosylphosphatidylinositol-specific phospholipase D predicts the change in insulin sensitivity in response to a low-fat but not a low-carbohydrate diet in obese women
Metab. Clin. Exp.
57
473-478
2008
Homo sapiens
brenda
Raikwar, N.S.; Bowen-Deeg, R.F.; Du, X.S.; Low, M.G.; Deeg, M.A.
Glycosylphosphatidylinositol-specific phospholipase D improves glucose tolerance
Metab. Clin. Exp.
59
1413-1420
2010
Mus musculus, Mus musculus C57BL/6
brenda
Lindqvist, M.; Wallinder, J.; Bergstroem, J.; Henriksson, A.E.
Plasma glycosylphosphatidylinositol phospholipase D (GPI-PLD) and abdominal aortic aneurysm
Int. J. Clin. Exp. Med.
5
306-309
2012
Homo sapiens
brenda
Masuda, S.; Fujishima, Y.; Maeda, N.; Tsugawa-Shimizu, Y.; Nakamura, Y.; Tanaka, Y.; Obata, Y.; Fukuda, S.; Nagao, H.; Kita, S.; Nishizawa, H.; Shimomura, I.
Impact of glycosylphosphatidylinositol-specific phospholipase D on hepatic diacylglycerol accumulation, steatosis, and insulin resistance in diet-induced obesity
Am. J. Physiol. Endocrinol. Metab.
316
E239-E250
2019
Homo sapiens (P80108), Homo sapiens, Mus musculus (Q7TNZ4), Rattus norvegicus (Q8R2H5)
brenda
Ritorto, M.S.; Rhode, H.; Vogel, A.; Borlak, J.
Regulation of glycosylphosphatidylinositol-anchored proteins and GPI-phospholipase D in a c-Myc transgenic mouse model of hepatocellular carcinoma and human HCC
Biol. Chem.
397
1147-1162
2016
Mus musculus (O70362), Mus musculus, Homo sapiens (P80108), Homo sapiens
brenda
Jin, J.K.; Jang, B.; Jin, H.T.; Choi, E.K.; Jung, C.G.; Akatsu, H.; Kim, J.I.; Carp, R.I.; Kim, Y.S.
Phosphatidylinositol-glycan-phospholipase D is involved in neurodegeneration in prion disease
PLoS ONE
10
e0122120
2015
Mus musculus (O70362), Homo sapiens (P80108), Homo sapiens
brenda
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Release 2023.1 (January 2023)
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