Information on EC 3.1.4.48 - dolichylphosphate-glucose phosphodiesterase

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The expected taxonomic range for this enzyme is: Dictyostelium discoideum

EC NUMBER
COMMENTARY
3.1.4.48
-
RECOMMENDED NAME
GeneOntology No.
dolichylphosphate-glucose phosphodiesterase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
dolichyl beta-D-glucosyl phosphate + H2O = dolichyl phosphate + D-glucose
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hydrolysis of phosphoric diester
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Metabolic pathways
-
N-Glycan biosynthesis
-
SYSTEMATIC NAME
IUBMB Comments
dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase
-
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
dol-P-Glc phosphodiesterase
-
-
-
-
dolichol phosphoglucose phosphodiesterase
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
89287-42-3
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
cellular slime mold, strain NC-4
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
dolichyl beta-D-glucosyl phosphate + H2O
dolichyl phosphate + D-glucose
show the reaction diagram
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Ca2+
-
less than 10% of the activation with Mn2+
Mg2+
-
less than 10% of the activation with Mn2+
Mn2+
-
dependent on, can activate in presence of potassium phosphate, Km for MnCl2 less than 1 mM
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
PCMB
-
completely inhibited by 1 mM
UDP-GlcUA
-
most effective inhibitor, 0.025-0.050 mM, 50% inhibition
additional information
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not markedly inhibited by alpha-or beta-glucosides or by nucleotides, exhibits a very low capacity to transfer glucose to endogenous oligosaccharide-lipid or protein acceptors in presence of EDTA, MgCl2 or CaCl2
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ACTIVATING COMPOUND
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
TEMPERATURE OPTIMUM
TEMPERATURE OPTIMUM MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE