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Information on EC 3.1.4.46 - glycerophosphodiester phosphodiesterase and Organism(s) Mus musculus and UniProt Accession Q640M6

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.46 glycerophosphodiester phosphodiesterase
IUBMB Comments
Broad specificity for glycerophosphodiesters; glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoglycerol and bis(glycerophospho)-glycerol are hydrolysed.
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This record set is specific for:
Mus musculus
UNIPROT: Q640M6
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
glycerophosphodiester phosphodiesterase, lipoprotein d, glpq2, igd-binding protein, glpq1, gpd protein, outer membrane protein d, pfgdpd, gpcpd1, ttgdpd, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
GDE2
-
-
gene hpd protein
-
-
-
-
GlpQ
-
-
-
-
glycerophosphodiester phosphodiesterase
glycerophosphoryl diester phosphodiesterase
-
-
-
-
GP-PDE
-
-
GPX-PDE
-
-
-
-
IGD-binding protein
-
-
-
-
IgD-binding protein D
-
-
-
-
immunoglobulin D-binding protein
-
-
-
-
phosphodiesterase, glycerophosphodiester
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-
-
-
phosphohydrolase GpdQ
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of carboxylic diester
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -
SYSTEMATIC NAME
IUBMB Comments
glycerophosphodiester glycerophosphohydrolase
Broad specificity for glycerophosphodiesters; glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoglycerol and bis(glycerophospho)-glycerol are hydrolysed.
CAS REGISTRY NUMBER
COMMENTARY hide
86280-59-3
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
glycerophosphodiester + H2O
glycerol 3-phosphate + alcohol
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
glycerophosphodiester + H2O
glycerol 3-phosphate + alcohol
show the reaction diagram
-
-
-
-
?
additional information
?
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GDE2 mRNA
Manually annotated by BRENDA team
GDE2 mRNA
Manually annotated by BRENDA team
GDE2 mRNA
Manually annotated by BRENDA team
GDE2 mRNA
Manually annotated by BRENDA team
osteoblast-like cells
Manually annotated by BRENDA team
GDE2 and GDE6 mRNA
Manually annotated by BRENDA team
-
widely expressed in the adult mouse brain
Manually annotated by BRENDA team
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expression of GDE2 is significantly upregulated during neuronal differentiation by retinoic acid treatment hippocampus
Manually annotated by BRENDA team
-
primary neurons
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
enzyme co-localizes with actin cytoskeleton
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
-
phylogenetic analysis, overview
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GDPD5_MOUSE
607
6
68890
Swiss-Prot
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
61000
x * 61000, deduced from gene sequence
68910
calculated from cDNA sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 61000, deduced from gene sequence
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
GP-PDE plays a role in the regulation of cytoskeletal modification
additional information
-
a loss of function mutant of Neuro2A fails to form neurites upon retinoic acid treatment
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
sonication, centrifugation, dialysis against PBS
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
isolation of cDNAs encoding GDE2 and GDE6, cloned by using mouse brain cDNA libraries, expression in Escherichia coli JM109
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yanaka, N.; Imai, Y.; Kawai, E.; Akatsuka, H.; Wakimoto, K.; Nogusa, Y.; Kato, N.; Chiba, H.; Kotani, E.; Omori, K.; Sakurai, N.
Novel membrane protein containing glycerophosphodiester phosphodiesterase motif is transiently expressed during osteoblast differentiation
J. Biol. Chem.
278
43595-43602
2003
Mus musculus (Q640M6), Mus musculus, Homo sapiens (Q9HCC8)
Manually annotated by BRENDA team
Nogusa, Y.; Fujioka, Y.; Komatsu, R.; Kato, N.; Yanaka, N.
Isolation and characterization of two serpentine membrane proteins containing glycerophosphodiester phosphodiesterase, GDE2 and GDE6
Gene
337
173-179
2004
Mus musculus (Q640M6), Mus musculus
Manually annotated by BRENDA team
Yanaka, N.; Nogusa, Y.; Fujioka, Y.; Yamashita, Y.; Kato, N.
Involvement of membrane protein GDE2 in retinoic acid-induced neurite formation in Neuro2A cells
FEBS Lett.
581
712-718
2007
Mus musculus
Manually annotated by BRENDA team
Corda, D.; Mosca, M.; Ohshima, N.; Grauso, L.; Yanaka, N.; Mariggio, S.
The emerging physiological roles of the glycerophosphodiesterase family
FEBS J.
281
998-1016
2014
Agrobacterium tumefaciens, Arabidopsis thaliana, Bacillus pumilus, Bacillus pumilus DSM 27, Bacillus subtilis (P54527), Borrelia hermsii (Q45201), Caldanaerobacter subterraneus subsp. tengcongensis, Escherichia coli (P09394), Escherichia coli (P10908), Haemophilus influenzae (Q06282), Haemophilus influenzae DSM 11121 (Q06282), Homo sapiens (Q8WTR4), Homo sapiens (Q9NPB8), Klebsiella aerogenes, Lupinus albus, Mus musculus, Musca domestica, Mycoplasma hyorhinis (E0TL71), Mycoplasma pneumoniae (P75367), Pasteurella multocida (Q79LP3), Plasmodium falciparum, Rattus norvegicus, Saccharomyces cerevisiae, Saccharomyces cerevisiae (Q02979), Staphylococcus aureus (Q99387), Streptomyces coelicolor, Thermotoga maritima, Treponema pallidum (O30405)
Manually annotated by BRENDA team