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Information on EC 3.1.4.40 - CMP-N-acylneuraminate phosphodiesterase
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3.1.4.40 CMP-N-acylneuraminate phosphodiesteraseSpecify your search results
Word Map
- 3.1.4.40
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mutans
- glucans
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paenibacillus
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harzianum
-
trichoderma
-
biofilms
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caries
-
streptococcal
-
dental
-
water-insoluble
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saccharification
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curdlanolyticus
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cariogenic
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laetiporus
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sulphureus
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glucanohydrolases
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dentistry
- dextranase
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sialyltransferase
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sobrinus
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glucosyltransferases
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
cmp-sialic acid hydrolase, cmp-n-acetylneuraminate n-acylneuraminohydrolase, cmp-n-acetylneuraminate hydrolase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
CMP-N-acetylneuraminate hydrolase
-
-
-
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CMP-N-acylneuraminic acid hydrolase
-
-
-
-
CMP-sialate hydrolase
-
-
-
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CMP-sialic acid hydrolase
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-
-
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cytidine monophosphate-N-acetylneuraminic acid hydrolase
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-
-
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cytidine monophosphosialic hydrolase
-
-
-
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hydrolase, cytidine monophosphosialate
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-
-
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phosphodiesterase, cytidine monophosphoacylneuraminate
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-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
CMP-N-acylneuraminate + H2O = CMP + N-acylneuraminate
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
CMP-N-acylneuraminate N-acylneuraminohydrolase
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CAS REGISTRY NUMBER
COMMENTARY
55326-41-5
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CMP-N-acylneuraminate + H2O
CMP + N-acylneuraminate
-
-
-
ir
CMP-N-acylneuraminate + H2O
CMP + N-acylneuraminate
-
-
-
-
?
deoxythymidine-5'-p-nitrophenyl phosphate + H2O
deoxythymidine + 4-nitrophenol
-
-
-
-
?
deoxythymidine-5'-p-nitrophenyl phosphate + H2O
deoxythymidine + 4-nitrophenol
-
-
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
divalent cations
-
required, monovalent metal ions without or little stimulatory effect
Mg2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
1-methyl-1-nitroso-3-nitroguanidine
-
carcinogen, induces gastric tumors, reduces enzyme activity
carrageen
-
reduced activity of the enzyme after 8 h and 3 days after injection, mostly normal by 7 days
-
dithiothreitol
-
84% inhibition by 25 mM reduced dithiothreitol, 0% inhibition by 25 mM oxidized dithiotreitol
glutathione
-
62% inhibition by 25 mM reduced glutathione, 15% inhibition by 25 mM oxidized glutathione
Urate
-
reduced activity of the enzyme after 8 h and 3 days after injection, mostly normal by 7 days
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
from skin of normal individuals and patients with salla disease
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
sinusoidal and/or lateral surface of hepatocytes
brenda
-
sinusoidal and/or lateral surface of hepatocytes
-
brenda
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, plasma membranes, 1 year, microsomes, 3 months, no loss of activity
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0-4°C, different sucrose concentrations, for several days, no inactivation
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0°C, for several days no loss of activity, by the 25th day 42% of initial activity remains
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repeated freezing and thawing, no influence of enzyme activity
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Corfield, A.P.; Clamp, J.R.; Wagner, S.A.
The metabolism of sialic acids in isolated rat colonic mucosal cells
Biochem. Soc. Trans.
11
767-768
1983
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
-
brenda
Corfield, A.P.; Rainey, J.B.; Clamp, J.R.; Wagner, S.A.
Rat colonic mucosal cell sialic acid metabolism in azoxymethane-induced tumours
Biochim. Biophys. Acta
840
264-270
1985
Rattus norvegicus
brenda
Corfield, A.P.; Clamp, J.R.; Wagner, S.A.
The metabolism of sialic acids in isolated rat colonic mucosal cells
Biochem. J.
226
163-174
1985
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Corfield, A.P.; Stewart, I.; Houghton, P.W.J.; Mortensen, N.J.McC.; Williamson, R.C.N.; Clamp, J.R.
Changes in enzymes involved in sialic acid and hexosamine metabolism in a gastric cancer model
Biochem. Soc. Trans.
15
1052
1987
Rattus norvegicus, Rattus norvegicus Wistar
-
brenda
Corfield, A.P.; Hutton, C.W.; Clamp, J.R.; Dieppe, P.A.
Changes in sialic acid metabolism occur in colon and liver during the acute-phase response
Biochem. Soc. Trans.
14
628-629
1986
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
-
brenda
Masson, L.; Holbein, B.E.
Influence of nutrient limitation and low pH on serogroup B Neisseria meningitidis capsular polysaccharide levels: correlation with virulence for mice
Infect. Immun.
47
465-471
1985
Neisseria meningitidis
brenda
Muilerman, H.G.; Lasthuis, A.M.; Hooghwinkel, G.J.M.; Van Dijk, W.
On the presence of two non-specific nucleotide-sugar-hydrolysing enzymes in rat liver
Biochem. J.
220
95-103
1984
Rattus norvegicus, Rattus norvegicus Wistar
brenda
Corfield, A.P.; Rainey, J.B.; Clamp, J.R.; Wagner, S.A.
Changes in the activity of the enzymes involved in sialic acid metabolism in isolated rat colonic mucosal cells on administration of azoxymethane
Biochem. Soc. Trans.
11
766-767
1983
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
-
brenda
Van Dijk, W.; Lasthuis, A.M.; Trippelvitz, L.A.W.; Muilerman, H.G.
Increased glycosylation capacity in regenerating rat liver is paralleled by decreased activities of CMP-N-acetylneuraminate hydrolase and UDP-galactose pyrophosphatase
Biochem. J.
214
1003-1006
1983
Rattus norvegicus, Rattus norvegicus Wistar
brenda
Masson, L.; Holbein, B.E.
Physiology of sialic acid capsular polysaccharide synthesis in serogroup B Neisseria meningitidis
J. Bacteriol.
154
728-736
1983
Neisseria meningitidis
brenda
Renlund, M.; Chester, M.A.; Lundblad, A.; Parkkinen, J.; Krusius, T.
Free N-acetylneuraminic acid in tissues in Salla disease and the enzymes involved in its metabolism
Eur. J. Biochem.
130
39-45
1983
Homo sapiens
brenda
Van Dijk, W.; Lasthuis, A.M.; Koppen, P.L.; Muilerman, H.G.
A universal and rapid spectrophotometric assay of CMP-sialic acid hydrolase and nucleoside-diphosphosugar pyrophosphatase activities and detection in polyacrylamide gels
Anal. Biochem.
117
346-353
1981
Rattus norvegicus
brenda
Spik, G.; Six, P.; Bouquelet, S.; Sawicka, T.; Montreuil, J.
Degradation of nucleoside diphosphate sugars by human and rat serum. Properties of the serum nucleotide pyrophosphatases
Glycoconjugate Res.
2
933-936
1979
Homo sapiens, Rattus norvegicus
-
brenda
Van Dijk, W.; Maier, H.; Van den Eijnden, D.H.
CMP-N-acetylneuraminic acid hydrolase, an ectoenzyme distributed unevenly over the hepatocyte surface
Biochim. Biophys. Acta
466
187-197
1977
Rattus norvegicus, Rattus norvegicus Wistar
brenda
Van Dijk, W.; Maier, H.; Van den Eijnden, D.H.
Properties and subcellular localization of CMP-N-acetylneuraminic acid hydrolase of calf kidney
Biochim. Biophys. Acta
444
816-834
1976
Bos taurus
brenda
Kean, E.L.; Bighouse, K.J.
Cytidine 5-monophosphosialic acid hydrolase. Subcellular location and properties
J. Biol. Chem.
249
7813-7823
1974
Rattus norvegicus
brenda
Edwards, U.; Muller, A.; Hammerschmidt, S.; Gerardy-Schahn, R.; Frosch, M.
Molecular analysis of the biosynthesis pathway of the alpha-2,8 polysialic acid capsule by Neisseria meningitidis serogroup B
Mol. Microbiol.
14
141-149
1994
Neisseria meningitidis
brenda
Van Dijk, W.; Van den Eijnden, D.H.
Cytidine 5'-phosphate-N-acetylneuraminic acid hydrolase in calf kidney: properties and subcellular distribution
Biochem. Soc. Trans.
2
642-645
1974
Bos taurus
-
brenda
Lepers, A.; Shaw, L.; Schneckenburger, P.; Cacan, R.; Verbert, A.; Schauer, R.
A study on the regulation of N-glycoloylneuraminic acid biosynthesis and utilization in rat and mouse liver
Eur. J. Biochem.
193
715-723
1990
Mus musculus, Rattus norvegicus, Rattus norvegicus Wistar
brenda
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