Information on EC 3.1.4.4 - phospholipase D and Organism(s) Dictyostelium discoideum and UniProt Accession Q54UK0

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This record set is specific for:
Dictyostelium discoideum
UNIPROT: Q54UK0


The expected taxonomic range for this enzyme is: Bacteria, Eukaryota


The taxonomic range for the selected organisms is: Dictyostelium discoideum

EC NUMBER
COMMENTARY hide
3.1.4.4
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RECOMMENDED NAME
GeneOntology No.
phospholipase D
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
choline biosynthesis III
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phosphatidate metabolism, as a signaling molecule
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phospholipases
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glycine betaine biosynthesis
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Glycerophospholipid metabolism
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Ether lipid metabolism
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Metabolic pathways
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Biosynthesis of secondary metabolites
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SYSTEMATIC NAME
IUBMB Comments
phosphatidylcholine phosphatidohydrolase
Also acts on other phosphatidyl esters.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-87-0
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
isozyme PLDA; three isozymes PLDA, PLDB, and PDLC, encoded by genes plda, pldb, and pldc
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
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cells lacking PldB preferentially sort to the stalk in chimeric fruiting bodies with wild-type cells
metabolism
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PldB mediates quorum sensing in the CMF pathway and regulates the dissociation of G protein Galpha2betagamma
physiological function
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PldB regulates cAMP chemotaxis, overview. Phospholipase D controls Dictyostelium development by regulating G protein signaling, its activity is required for CMF to alter the kinetics of cAMP-induced G protein signaling, overview
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
phosphatidylcholine + H2O
choline + phosphatidate
show the reaction diagram
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?
phosphatidylcholine + H2O
choline + phosphatidate
show the reaction diagram
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?
phosphatidylcholine + H2O
phosphatidic acid + choline
show the reaction diagram
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a phospholipid transphosphatidylation reaction
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?
additional information
?
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phospholipase D activity is essential for actin localization and actin-based motility
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
phosphatidylcholine + H2O
choline + phosphatidate
show the reaction diagram
Q54UK0, Q54WR4, Q54Z25
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?
phosphatidylcholine + H2O
choline + phosphatidate
show the reaction diagram
Q54UK0, Q54WR4, Q54Z25
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?
additional information
?
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phospholipase D activity is essential for actin localization and actin-based motility
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic tree, expression analysis and regulation
DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic tree, expression analysis and regulation
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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construction of a pldB disruption mutant by nucleotide replacement