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Information on EC 3.1.4.35 - 3',5'-cyclic-GMP phosphodiesterase and Organism(s) Rattus norvegicus and UniProt Accession Q8QZV1

for references in articles please use BRENDA:EC3.1.4.35
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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.35 3',5'-cyclic-GMP phosphodiesterase
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This record set is specific for:
Rattus norvegicus
UNIPROT: Q8QZV1 not found.
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Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
phosphodiesterase type 5, phosphodiesterase-5, pde-5, phosphodiesterase 5, cgmp phosphodiesterase, pde5a, cyclic gmp phosphodiesterase, phosphodiesterase type-5, pde6b, cgmp-phosphodiesterase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
cGMP-specific phosphodiesterase type 9
-
3',5'-cyclic GMP phosphodiesterase
-
-
-
-
cd-PDE5
catalytic domain of PDE5
cGMP phosphodiesterase
cGMP phosphodiesterase 5
-
-
cGMP-PDE
cGMP-phosphodiesterase
-
-
cGMP-specific cGMP-binding phosphodiesterase
-
-
cGMP-specific phosphodiesterase 5
-
-
cGMP-specific phosphodiesterase-5
-
cyclic 3',5'-GMP phosphodiesterase
-
-
-
-
cyclic GMP hydrolyzing phosphodiesterase 5
-
-
cyclic GMP phosphodiesterase
-
-
-
-
cyclic GMP-phosphodiesterase
-
-
cyclic guanosine 3',5'-monophosphate phosphodiesterase
-
-
-
-
cyclic guanosine 3',5'-phosphate phosphodiesterase
-
-
-
-
cyclic guanosine monophosphate-specific phosphodiesterase 5
-
-
cyclic-GMP phosphodiesterase
-
-
guanosine 3',5'-cyclicmonophosphate-specific PDE
-
-
guanosine cyclic 3',5'-phosphate phosphodiesterase
-
-
-
-
phosphodiesterase cGMP
-
-
-
-
phosphodiesterase subtype 5
-
-
phosphodiesterase type 5
-
-
phosphodiesterase type-5
-
-
phosphodiesterase, guanosine cyclic 3',5'-phosphate
-
-
-
-
phosphodiesterase-5
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
3',5'-cyclic-GMP 5'-nucleotidohydrolase
-
CAS REGISTRY NUMBER
COMMENTARY hide
9068-52-4
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
show the reaction diagram
-
-
?
2'-O-anthraniloyl cGMP + H2O
2'-O-anthraniloyl GMP
show the reaction diagram
-
-
-
?
3',5'-cGMP + H2O
5'-GMP
show the reaction diagram
cGMP + H2O
5'-GMP
show the reaction diagram
-
-
-
-
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
show the reaction diagram
-
-
?
3',5'-cGMP + H2O
5'-GMP
show the reaction diagram
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,3-dimethyl-6-(2-propoxy-5-methanesulfonylamidophenyl)pyrazol[3,4d]-pyrimidin-4-(5H)-one
-
0.000006 mM, 50% inhibition in sham operated rats
3',5'-cAMP
-
-
3-(4-ethylpiperazin-1-yl)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
-
-
3-([2-[(2-hydroxyethyl)amino]ethyl]amino)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
-
-
3-isobutyl-1-methylxanthine
-
-
3-[(1R,4R)-2,5-diazabicyclo[2.2.1]hept-2-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
-
-
3-[(2-aminoethyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
-
-
3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
-
-
3-[4-(2,2-dihydroxypropyl)-1,4-diazepan-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
-
-
3-[4-(2-hydroxyethyl)-1,4-diazepan-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
-
-
3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]-pyrazin-2(1H)-one
-
-
3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
-
a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5
3-[4-(3-hydroxypropyl)-1,4-diazepan-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
-
-
3-[4-(3-hydroxypropyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
-
-
3-[4-[(2R)-2-hydroxypropyl]-1,4-diazepan-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
-
-
3-[4-[(2R,3R)-3-hydroxybutan-2-yl]-1,4-diazepan-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
-
-
3-[4-[(2S)-2-hydroxypropyl]-1,4-diazepan-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
-
-
3-[4-[(2S,3R)-3-hydroxybutan-2-yl]-1,4-diazepan-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
-
-
7-(6-methoxypyridin-3-yl)-3-(piperazin-1-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
-
-
BAY 60-7550
-
-
carboxyamidotriazole
-
non-selective inhibition
Cilostamide
-
-
dipyridamole
-
-
MY-5445
-
inhibition significantly increases contractility in hypertrophied myocardium
PF-3717842
high-affinity phosphodiesterase-5 inhibitor
rolipram
-
-
sildenafil
T0156
-
selective phosphodiesterase type 5 inhibitor
tadalafil
vardenafil
zaprinast
additional information
-
not affected by cilostazol and rolipram
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cGMP
-
allosteric activation
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.012
2'-O-anthraniloyl cGMP
-
37°C, pH 7.4
0.003
3',5'-cGMP
-
-
0.0015
cGMP
-
37°C, pH 7.4
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0000045
1,3-dimethyl-6-(2-propoxy-5-methanesulfonylamidophenyl)pyrazol[3,4d]-pyrimidin-4-(5H)-one
-
sham-operated rats
0.00031
zaprinast
-
sham-operated rats
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00000022
3-(4-ethylpiperazin-1-yl)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00000112
3-([2-[(2-hydroxyethyl)amino]ethyl]amino)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00000238
3-[(1R,4R)-2,5-diazabicyclo[2.2.1]hept-2-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00000025
3-[(2-aminoethyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00000021
3-[4-(2,2-dihydroxypropyl)-1,4-diazepan-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00000072
3-[4-(2-hydroxyethyl)-1,4-diazepan-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0000002
3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]-pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0000002
3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00000108
3-[4-(3-hydroxypropyl)-1,4-diazepan-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00000018
3-[4-(3-hydroxypropyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00000023
3-[4-[(2R)-2-hydroxypropyl]-1,4-diazepan-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0000003
3-[4-[(2R,3R)-3-hydroxybutan-2-yl]-1,4-diazepan-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00000031
3-[4-[(2S)-2-hydroxypropyl]-1,4-diazepan-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00000033
3-[4-[(2S,3R)-3-hydroxybutan-2-yl]-1,4-diazepan-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00000328
7-(6-methoxypyridin-3-yl)-3-(piperazin-1-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00475
carboxyamidotriazole
Rattus norvegicus
-
enzyme from brain, at pH 8.0 and 30°C
0.00185
sildenafil
Rattus norvegicus
-
enzyme from brain, at pH 8.0 and 30°C
0.00013
zaprinast
Rattus norvegicus
-
pH and temperature not specified in the publication
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000012
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
strongest PDE9A expression in Purkinje cells
Manually annotated by BRENDA team
pyramidal cells and granule cells
Manually annotated by BRENDA team
-
higher expression than in corpus cavernosum
Manually annotated by BRENDA team
-
PDE5 vascular expression is decreased in arteries from angiotensin II hypertensive rats compared to control rats
Manually annotated by BRENDA team
-
vascular endothelium and muscle fibers, castration decreases and T supplementation restores PDE5 gene expression
Manually annotated by BRENDA team
-
high activity in intact platetelts
Manually annotated by BRENDA team
-
enzyme isoform PDE5 mRNA and protein are markedly upregulated in hypertrophied right ventricle
Manually annotated by BRENDA team
-
phosphodiesterase 5
Manually annotated by BRENDA team
-
muscle fibers of bladder
Manually annotated by BRENDA team
-
phosphodiesterase 5
Manually annotated by BRENDA team
-
in freshly isolated peritoneal exudate macrophage, isoform PDE5 is expressed. After 24h of cultures, PDE5 is no longer present
Manually annotated by BRENDA team
-
phosphodiesterase 5
Manually annotated by BRENDA team
-
in the rod photoreceptor PDE is entirely localized within the rod outer segment
Manually annotated by BRENDA team
cervical spinal cord, expression of isoforms PDE2, PDE5, and PDE9 in all lamina, in ventral motor neurons and in ependymal cells lining the central canal. Study on the influence of enzyme activity on NO-stimulated cGMP levels
Manually annotated by BRENDA team
-
PDE5 is present in young and adult gland
Manually annotated by BRENDA team
-
constitutively present. No change in PDE-5 protein expression throughout pregnancy
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
-
modulation of the NO-cGMP pathway using the PDE-5 inhibitor zaprinast alters the display of paced mating behaviors in rats
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PDE9A_RAT
534
0
61756
Swiss-Prot
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
61756
x * 61756, deduced from nucleotide sequence
400000
-
gel filtration
90000 - 99000
-
the antibody against PDE5 recognizes a 90000/99000 Da doublet band, SDS-PAGE
92000
-
2 * 92000, sucrose density gradient centrifugation
98000
theoretical value
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 61756, deduced from nucleotide sequence
dimer
-
2 * 92000, sucrose density gradient centrifugation
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
DEAE-Sepharose, Blue-Sepharose, calmodulin-conjugated Sepharose, partially purified
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
angiotensin II induces PDE5 expression in vitro
-
isoforms PDE1B, PDE1C, PDE2A, PDE4A, PDE4D, PDE5A, PDE7A, PDE8A, PDE8B, PDE10A, and PDE11A show an age-related increase or decrease in mRNA expression in at least 1 of the 4 brain regions examined (hippocampus, cortex, striatum, and cerebellum). mRNA expression of isoforms PDE1A, PDE3A, PDE3B, PDE4B, PDE7A, PDE7B, and PDE9A does not change with age
-
nitroglycerin tolerance may involve an increased activity of PDE5
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
molecular biology
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Francis, S.H.; Corbin, J.D.
Purification of cGMP-binding protein phosphodiesterase from rat lung
Methods Enzymol.
159
722-729
1988
Rattus norvegicus
Manually annotated by BRENDA team
Russell, T.R.; Terasaki, W.L.; Appleman, M.M.
Separate phosphodiesterases for the hydrolysis of cyclic adenosine 3,5-monophosphate and cyclic guanosine 3,5-monophosphate in rat liver
J. Biol. Chem.
248
1334-1340
1973
Rattus norvegicus
Manually annotated by BRENDA team
Tanaka, S.; Shimooka, S.; Shimomura, H.
Changes in phosphodiesterase activity in the developing rat submandibular gland
Arch. Oral Biol.
47
567-576
2002
Rattus norvegicus
Manually annotated by BRENDA team
Okada, D.; Asakawa, S.
Allosteric activation of cGMP-specific, cGMP-binding phosphodiesterase (PDE5) by cGMP
Biochemistry
41
9672-9679
2002
Rattus norvegicus
Manually annotated by BRENDA team
Hosogai, N.; Seki, J.; Goto, T.
Reciprocal regulation of cyclic GMP content by cyclic GMP-phosphodiesterase and guanylate cyclase in SHR with CsA-induced nephrotoxicity
Br. J. Pharmacol.
134
995-1002
2001
Rattus norvegicus
Manually annotated by BRENDA team
van Staveren, W.C.; Glick, J.; Markerink-van Ittersum, M.; Shimizu, M.; Beavo, J.A.; Steinbusch, H.W.; de Vente, J.
Cloning and localization of the cGMP-specific phosphodiesterase type 9 in the rat brain
J. Neurocytol.
31
729-741
2002
Mus musculus (O70628), Mus musculus, Rattus norvegicus (Q8QZV1)
Manually annotated by BRENDA team
Ni, X.P.; Safai, M.; Gardner, D.G.; Humphreys, M.H.
Increased cGMP phosphodiesterase activity mediates renal resistance to ANP in rats with bile duct ligation
Kidney Int.
59
1264-1273
2001
Rattus norvegicus
Manually annotated by BRENDA team
Buhimschi, C.S.; Garfield, R.E.; Weiner, C.P.; Buhimschi, I.A.
The presence and function of phosphodiesterase type 5 in the rat myometrium
Am. J. Obstet. Gynecol.
190
268-274
2004
Rattus norvegicus
Manually annotated by BRENDA team
Castro, L.R.; Verde, I.; Cooper, D.M.; Fischmeister, R.
Cyclic guanosine monophosphate compartmentation in rat cardiac myocytes
Circulation
113
2221-2228
2006
Rattus norvegicus
Manually annotated by BRENDA team
Scipioni, A.; Stefanini, S.; Santone, R.; Giorgi, M.
Immunohistochemical localisation of PDE5 in Leydig and myoid cells of prepuberal and adult rat testis
Histochem. Cell Biol.
124
401-407
2005
Rattus norvegicus
Manually annotated by BRENDA team
Mo, E.; Amin, H.; Bianco, I.H.; Garthwaite, J.
Kinetics of a cellular nitric oxide/cGMP/phosphodiesterase-5 pathway
J. Biol. Chem.
279
26149-26158
2004
Rattus norvegicus
Manually annotated by BRENDA team
Keravis, T.; Thaseldar-Roumie, R.; Lugnier, C.
Assessment of phosphodiesterase isozyme contribution in cell and tissue extracts
Methods Mol. Biol.
307
63-74
2005
Rattus norvegicus
Manually annotated by BRENDA team
Knight, S.; Snellen, H.; Humphreys, M.; Baylis, C.
Increased renal phosphodiesterase-5 activity mediates the blunted natriuretic response to ANP in the pregnant rat
Am. J. Physiol. Renal Physiol.
292
F655-F659
2007
Rattus norvegicus
Manually annotated by BRENDA team
Witwicka, H.; Kobialka, M.; Siednienko, J.; Mitkiewicz, M.; Gorczyca, W.A.
Expression and activity of cGMP-dependent phosphodiesterases is up-regulated by lipopolysaccharide (LPS) in rat peritoneal macrophages
Biochim. Biophys. Acta
1773
209-218
2007
Rattus norvegicus
Manually annotated by BRENDA team
Nagendran, J.; Archer, S.L.; Soliman, D.; Gurtu, V.; Moudgil, R.; Haromy, A.; St Aubin, C.; Webster, L.; Rebeyka, I.M.; Ross, D.B.; Light, P.E.; Dyck, J.R.; Michelakis, E.D.
Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility
Circulation
116
238-248
2007
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Filippi, S.; Morelli, A.; Sandner, P.; Fibbi, B.; Mancina, R.; Marini, M.; Gacci, M.; Vignozzi, L.; Vannelli, G.B.; Carini, M.; Forti, G.; Maggi, M.
Characterization and functional role of androgen-dependent PDE5 activity in the bladder
Endocrinology
148
1019-1029
2007
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Rutten, K.; Prickaerts, J.; Hendrix, M.; van der Staay, F.J.; Sik, A.; Blokland, A.
Time-dependent involvement of cAMP and cGMP in consolidation of object memory: studies using selective phosphodiesterase type 2, 4 and 5 inhibitors
Eur. J. Pharmacol.
558
107-112
2007
Rattus norvegicus
Manually annotated by BRENDA team
de Vente, J.; Markerink-van Ittersum, M.; Vles, J.S.
The role of phosphodiesterase isoforms 2, 5, and 9 in the regulation of NO-dependent and NO-independent cGMP production in the rat cervical spinal cord
J. Chem. Neuroanat.
31
275-303
2006
Rattus norvegicus (O54735)
Manually annotated by BRENDA team
Domek-Lopacinska, K.; Strosznajder, J.B.
The effect of selective inhibition of cyclic GMP hydrolyzing phosphodiesterases 2 and 5 on learning and memory processes and nitric oxide synthase activity in brain during aging
Brain Res.
1216
68-77
2008
Rattus norvegicus
Manually annotated by BRENDA team
Chen, J.; Yoshida, T.; Bitensky, M.W.
Light-induced translocation of cyclic-GMP phosphodiesterase on rod disc membranes in rat retina
Mol. Vis.
14
2509-2517
2008
Rattus norvegicus
Manually annotated by BRENDA team
Matsumoto, S.; Hanai, T.; Uemura, H.; Levin, R.M.
Effects of chronic treatment with vardenafil, a phosphodiesterase 5 inhibitor, on female rat bladder in a partial bladder outlet obstruction model
BJU Int.
103
987-990
2009
Rattus norvegicus
Manually annotated by BRENDA team
Radovits, T.; Boemicke, T.; Koekeny, G.; Arif, R.; Loganathan, S.; Kecsan, K.; Korkmaz, S.; Barnucz, E.; Sandner, P.; Karck, M.; Szabo, G.
The phosphodiesterase-5 inhibitor vardenafil improves cardiovascular dysfunction in experimental diabetes mellitus
Br. J. Pharmacol.
156
909-919
2009
Rattus norvegicus
Manually annotated by BRENDA team
Schaefer, S.; Ellinghaus, P.; Janssen, W.; Kramer, F.; Lustig, K.; Milting, H.; Kast, R.; Klein, M.
Chronic inhibition of phosphodiesterase 5 does not prevent pressure-overload-induced right-ventricular remodelling
Cardiovasc. Res.
82
30-39
2009
Rattus norvegicus
Manually annotated by BRENDA team
Dadvar, P.; Kovanich, D.; Folkers, G.E.; Rumpel, K.; Raijmakers, R.; Heck, A.J.
Phosphatidylethanolamine-binding proteins, including RKIP, exhibit affinity for phosphodiesterase-5 inhibitors
ChemBioChem
10
2654-2662
2009
Rattus norvegicus (O54735)
Manually annotated by BRENDA team
Toque, H.A.; Priviero, F.B.; Zemse, S.M.; Antunes, E.; Teixeira, C.E.; Webb, R.C.
Effect of the phosphodiesterase 5 inhibitors sildenafil, tadalafil and vardenafil on rat anococcygeus muscle: functional and biochemical aspects
Clin. Exp. Pharmacol. Physiol.
36
358-366
2009
Rattus norvegicus
Manually annotated by BRENDA team
Sun, X.Z.; Li, Z.F.; Liu, Y.; Fang, P.; Li, M.X.
Inhibition of cGMP phosphodiesterase 5 suppresses matrix metalloproteinase-2 production in pulmonary artery smooth muscles cells
Clin. Exp. Pharmacol. Physiol.
37
362-367
2010
Rattus norvegicus
Manually annotated by BRENDA team
Gotshall, R.W.; Hamilton, K.L.; Foreman, B.; van Patot, M.C.; Irwin, D.C.
Glutaraldehyde-polymerized bovine hemoglobin and phosphodiesterase-5 inhibition
Crit. Care Med.
37
1988-1993
2009
Rattus norvegicus
Manually annotated by BRENDA team
Kato, N.; Mashita, Y.; Kato, S.; Mitsufuji, S.; Yoshikawa, T.; Takeuchi, K.
Sildenafil, an inhibitor of phosphodiesterase subtype 5, prevents indomethacin-induced small-intestinal ulceration in rats via a NO/cGMP-dependent mechanism
Digest. Dis. Sci.
54
2346-2356
2009
Rattus norvegicus
Manually annotated by BRENDA team
Liu, C.Q.; Leung, F.P.; Lee, V.W.; Lau, C.W.; Yao, X.; Lu, L.; Huang, Y.
Prevention of nitroglycerin tolerance in vitro by T0156, a selective phosphodiesterase type 5 inhibitor
Eur. J. Pharmacol.
590
250-254
2008
Rattus norvegicus
Manually annotated by BRENDA team
Korkmaz, S.; Radovits, T.; Barnucz, E.; Neugebauer, P.; Arif, R.; Hirschberg, K.; Loganathan, S.; Seidel, B.; Karck, M.; Szabo, G.
Dose-dependent effects of a selective phosphodiesterase-5-inhibitor on endothelial dysfunction induced by peroxynitrite in rat aorta
Eur. J. Pharmacol.
615
155-162
2009
Rattus norvegicus
Manually annotated by BRENDA team
Iseri, S.O.; Ersoy, Y.; Ercan, F.; Yuksel, M.; Atukeren, P.; Gumustas, K.; Alican, I.
The effect of sildenafil, a phosphodiesterase-5 inhibitor, on acetic acid-induced colonic inflammation in the rat
J. Gastroenterol. Hepatol.
24
1142-1148
2009
Rattus norvegicus
Manually annotated by BRENDA team
Hughes, R.O.; Rogier, D.J.; Jacobsen, E.J.; Walker, J.K.; Macinnes, A.; Bond, B.R.; Zhang, L.L.; Yu, Y.; Zheng, Y.; Rumsey, J.M.; Walgren, J.L.; Curtiss, S.W.; Fobian, Y.M.; Heasley, S.E.; Cubbage, J.W.; Moon, J.B.; Brown, D.L.; Acker, B.A.; Maddux, T.M.; Tollefson, M.B.; Mischke, B.V.; Owen, D.R.; Freskos, J.N.; Molyneaux, J.M.; Benson, A.G.; Blevis-Bal, R.M.
Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5)
J. Med. Chem.
53
2656-2660
2010
Rattus norvegicus
Manually annotated by BRENDA team
Pifarre, P.; Prado, J.; Giralt, M.; Molinero, A.; Hidalgo, J.; Garcia, A.
Cyclic GMP phosphodiesterase inhibition alters the glial inflammatory response, reduces oxidative stress and cell death and increases angiogenesis following focal brain injury
J. Neurochem.
112
807-817
2010
Rattus norvegicus
Manually annotated by BRENDA team
Li, M.; Sun, X.; Li, Z.; Liu, Y.
Inhibition of cGMP phosphodiesterase 5 suppresses serotonin signalling in pulmonary artery smooth muscles cells
Pharmacol. Res.
59
312-318
2009
Rattus norvegicus
Manually annotated by BRENDA team
Clark, A.S.; Meerts, S.H.; Guarraci, F.A.
Zaprinast, a phosphodiesterase type-5 inhibitor, alters paced mating behavior in female rats
Physiol. Behav.
96
289-293
2009
Rattus norvegicus
Manually annotated by BRENDA team
Giachini, F.R.; Lima, V.V.; Carneiro, F.S.; Tostes, R.C.; Webb, R.C.
Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1
Hypertension
57
655-663
2011
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Kelly, M.P.; Adamowicz, W.; Bove, S.; Hartman, A.J.; Mariga, A.; Pathak, G.; Reinhart, V.; Romegialli, A.; Kleiman, R.J.
Select 3,5-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain
Cell. Signal.
26
383-397
2014
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Guo, L.; Luo, L.; Ju, R.; Chen, C.; Zhu, L.; Li, J.; Yu, X.; Ye, C.; Zhang, D.
Carboxyamidotriazole A novel inhibitor of both cAMP-phosphodiesterases and cGMP-phosphodiesterases
Eur. J. Pharmacol.
746
14-21
2015
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team