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Information on EC 3.1.4.3 - phospholipase C and Organism(s) Homo sapiens and UniProt Accession Q6UWR7
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3.1.4.3 phospholipase CIUBMB Comments
The bacterial enzyme, which is a zinc protein, also acts on sphingomyelin and phosphatidylinositol; that from seminal plasma does not act on phosphatidylinositol.
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Word Map
- 3.1.4.3
- inositol
- agonist
- phosphatidylinositol
- pkc
- phospholipid
- diacylglycerol
- phosphoinositide
- cyclase
- pertussis
- camp
-
phorbol
- g-proteins
- platelet
-
arachidonic
- 1,4,5-trisphosphate
- 4,5-bisphosphate
-
receptor-mediated
- vibrio
- thapsigargin
- trisphosphate
- adenylate
-
protein-coupled
-
blocker
-
adenylyl
- phospholipases
-
muscarinic
-
phosphatidic
- cereus
- carbachol
- perfringens
- pip2
-
fura-2
- neomycin
-
ca2+-free
-
phosphatidylinositol-specific
-
metabotropic
-
13-acetate
-
thromboxane
- nifedipine
- parahaemolyticus
- staurosporine
- bradykinin
- enterotoxin
-
desensitization
-
ryanodine
-
prelabeled
-
toxin-sensitive
-
store-operated
- chelerythrine
-
agonist-induced
- analysis
- drug development
- medicine
- food industry
- pharmacology
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
phospholipase c, plc, hemolysin, pc-plc, lecithinase, phosphatidylcholine-specific phospholipase c, plcbeta, plcg2, beta toxin, plcg1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
alpha-toxin
-
-
-
-
Beta toxin
-
-
-
-
Beta-hemolysin
-
-
-
-
Beta-toxin
-
-
-
-
Cbp
-
-
-
-
Clostridium oedematiens beta- and gamma-toxins
-
-
-
-
Clostridium welchii alpha-toxin
-
-
-
-
Gamma-toxin
-
-
-
-
Heat labile-hemolysin
-
-
-
-
heat-labile hemolysin
-
-
-
-
Hemolysin
-
-
-
-
Lecithinase
-
-
-
-
lecithinase C
-
-
-
-
lipophosphodiesterase C
-
-
-
-
lipophosphodiesterase I
-
-
-
-
MTP40 antigen
-
-
-
-
PC-PLC
phosphatidase C
-
-
-
-
Phosphatidylcholine cholinephosphohydrolase
-
-
-
-
PLC
-
-
-
-
SMase
-
-
-
-
sphingomyelinase
-
-
-
-
PC-PLC
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
KEGG
-
-, -, -, -
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SYSTEMATIC NAME
IUBMB Comments
phosphatidylcholine cholinephosphohydrolase
The bacterial enzyme, which is a zinc protein, also acts on sphingomyelin and phosphatidylinositol; that from seminal plasma does not act on phosphatidylinositol.
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CAS REGISTRY NUMBER
COMMENTARY
9001-86-9
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-arachidonoyl-2-lysophosphatidylcholine + H2O
1-arachidonoyl-sn-glycerol + phosphorylcholine
best substrate
-
-
?
1-arachidoyl-2-lysophosphatidylcholine + H2O
1-arachidoyl-sn-glycerol + phosphorylcholine
poor substrate
-
-
?
1-lauroyl-lysophosphatidylcholine + H2O
1-lauroyl-sn-glycerol + phosphorylcholine
potent substrate
-
-
?
1-linoleoyl-lysophosphatidylcholine + H2O
1-linoleoyl-sn-glycerol + phosphorylcholine
second best substrate
-
-
?
1-myristoyl-lysophosphatidylcholine + H2O
1-myristoyl-sn-glycerol + phosphorylcholine
potent substrate
-
-
?
1-oleoyl-lysophosphatidylcholine + H2O
1-oleoyl-sn-glycerol + phosphorylcholine
-
-
-
?
1-palmitoyl-lysophosphatidylcholine + H2O
1-palmitoyl-sn-glycerol + phosphorylcholine
-
-
-
?
1-stearoyl-lysophosphatidylcholine + H2O
1-stearoyl-sn-glycerol + phosphorylcholine
poor substrate
-
-
?
egg lysophosphatidylcholine + H2O
monoacylglycerol + phosphorylcholine
NPP6 is a choline-specific glycerophosphodiester phosphodiesterase. In marked difference to NPP2 (lysoPLD/autotaxin), which equally hydrolyzes lysophosphatidylcholine, 1-oleoyl lysophosphatidylethanolamine, 1-oleoyl lysophosphatidylserine, and porcine liver lysophosphatidylinositol to form lysophosphatidic acid, NPP6 hydrolyzes only lysophosphatidylcholine
-
-
?
glycerophosphorylcholine + H2O
glycerol + phosphorylcholine
enzyme hydrolyzes GPC efficiently, measurement of GDE activity
-
-
?
lysoPAF + H2O
?
lyso platelet activating factor, partially hydrolyzed
-
-
?
p-nitrophenyl phenylphosphate + H2O
p-nitrophenol + phenylphosphate
pNPPP, classical NPP substrate
-
-
?
p-nitrophenyl phosphorylcholine + H2O
p-nitrophenol + phosphorylcholine
pNPPC, classical NPP substrate, recombinant NPP6 efficiently hydrolyzes the classical substrate for phospholipase C
-
-
?
sphingosylphosphorylcholine + H2O
?
SPC, measurement of lysoPLC activity of NPP6 toward choline-containing phospholipids
-
-
?
phosphatidylinositol-bisphosphate + H2O
inositol 1,4,5-trisphosphate + 1,2-diacylglycerol
-
-
-
?
phosphatidylinositol-bisphosphate + H2O
inositol 1,4,5-trisphosphate + 1,2-diacylglycerol
-
-
-
?
phosphatidylinositol-bisphosphate + H2O
inositol 1,4,5-trisphosphate + 1,2-diacylglycerol
-
-
-
?
additional information
?
-
release of nucleoside 5'-monophosphate from a variety of nucleotides and nucleotide derivatives
-
-
?
additional information
?
-
-
release of nucleoside 5'-monophosphate from a variety of nucleotides and nucleotide derivatives
-
-
?
additional information
?
-
recombinant NPP6 does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'-monophosphate (pNP-TMP) and bis(p-nitrophenyl) phosphate. NPP6 does not act on sphingomyelin (SM)
-
-
?
additional information
?
-
-
recombinant NPP6 does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'-monophosphate (pNP-TMP) and bis(p-nitrophenyl) phosphate. NPP6 does not act on sphingomyelin (SM)
-
-
?
additional information
?
-
-
isoform PC-PLC plays an important role in regulating CD16 receptor membrane expression, the CD16-mediated cytolytic mechanism and CD16-triggered signal transduction
-
-
?
additional information
?
-
-
isoforms phosphatidylcholine-specific phospholipase C, i.e. PC-PLC, and phosphatidylinositol-specific phospholipase C, i.e. PI-PLC, control apoptosis by jointly regulating Akt phosphorylation, p53 expression, and affecting cell cycle in vascular endothelial cells
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
phosphatidylinositol-bisphosphate + H2O
inositol 1,4,5-trisphosphate + 1,2-diacylglycerol
-
-
-
?
phosphatidylinositol-bisphosphate + H2O
inositol 1,4,5-trisphosphate + 1,2-diacylglycerol
-
-
-
?
phosphatidylinositol-bisphosphate + H2O
inositol 1,4,5-trisphosphate + 1,2-diacylglycerol
-
-
-
?
additional information
?
-
release of nucleoside 5'-monophosphate from a variety of nucleotides and nucleotide derivatives
-
-
?
additional information
?
-
-
release of nucleoside 5'-monophosphate from a variety of nucleotides and nucleotide derivatives
-
-
?
additional information
?
-
-
isoform PC-PLC plays an important role in regulating CD16 receptor membrane expression, the CD16-mediated cytolytic mechanism and CD16-triggered signal transduction
-
-
?
additional information
?
-
-
isoforms phosphatidylcholine-specific phospholipase C, i.e. PC-PLC, and phosphatidylinositol-specific phospholipase C, i.e. PI-PLC, control apoptosis by jointly regulating Akt phosphorylation, p53 expression, and affecting cell cycle in vascular endothelial cells
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
additional information
Ca2+
-
recombinant PLC d3: maximum activity with 0.001 mM, recombinant PLC d1: maximum activity with 0.01 mM
additional information
none of the divalent cations tested (Ca2+, Mg2+, Zn2+, Ni2+, Co2+, Fe2+, and Cu2+) rescued the lost activity after treatment with EDTA, EGTA
additional information
-
none of the divalent cations tested (Ca2+, Mg2+, Zn2+, Ni2+, Co2+, Fe2+, and Cu2+) rescued the lost activity after treatment with EDTA, EGTA
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
EDTA
enzyme activity against 1-myristoyl-lysophosphatidylcholine, glycerophosphorylcholine, and p-nitrophenyl phosphorylcholine are readily inhibited by EDTA. Indicates that a divalent cation is essential for catalytic activity
EGTA
enzyme activity against 1-myristoyl-lysophosphatidylcholine, glycerophosphorylcholine, and p-nitrophenyl phosphorylcholine are readily inhibited by EGTA. Indicates that a divalent cation is essential for catalytic activity
48/80
-
compound 48/80, oligomeric mixture of condensation products of N-methyl-p-methoxyphenethylamine and formaldehyde. Specific inhibition of phosphatidylinositol-specific phospholipase C, i.e. PI-PLC. Suppression of PI-PLC promotes apoptosis of vascular endothelial cells by inhibiting Akt phosphorylation, elevating p53 expression, and affecting cell cycle distribution
tricyclodecan-9-yl-potassium xanthate
-
The recovery of both variables to their original levels in serum-restimulated (or lysophosphatidic acid-restimulated) EOC cells is strongly delayed, for at least 24 h, in the presence of the PC-PLC inhibitor tricyclodecan-9-yl-potassium xanthate (D609). The S-phase of serum-restimulated EONT cells is not sensitive to D609
D609
-
inhibitor of isoform PC-PLC, preincubation with D609 results in a dramatic decrease both in CD16 receptor and PC-PLC expression on the plasma membrane and reduction of CD16-mediated cytotoxicity
D609
-
specific inhibition of phosphatidylcholine-specific phospholipase C, i.e. PC-PLC. Suppression of PC-PLC promotes the phosphorylation of Akt protein
D609
-
suppression of isoform PC-PLC by D609 inhibits apoptosis in young cells, but not in senescent cells, and depresses reactive oxygen species levels in both young and senescent cells
tricyclodecan-9-yl-xanthogenate
-
inhibition is associated with decrease of enzyme exposed on cell surface and accumulation of cytoplasmic enzyme in Golgi region
-
tricyclodecan-9-yl-xanthogenate
-
preincubation of NK cells with a PC-PLC inhibitor, tricyclodecan-9-yl-xanthogenate, strongly reduced NK-mediated cytotoxicity
-
additional information
the catalytic activity of NPP6 toward p-nitrophenyl phosphorylcholine is partially inhibited by the divalent cations. Attempts are unsuccessful to recover the activity of EDTA treated NPP6 by adding various divalent cations
-
additional information
-
the catalytic activity of NPP6 toward p-nitrophenyl phosphorylcholine is partially inhibited by the divalent cations. Attempts are unsuccessful to recover the activity of EDTA treated NPP6 by adding various divalent cations
-
additional information
-
inhibition of enzyme leads to inhibition of IL-2 induced proliferation of cells
-
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
subunit of cell surface receptor associated G-protein
-
Gqa, subunit of cell surface receptor associated G-protein, PLC d1
-
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Threatened
RELATIONSHIP OF A HEMOLYSIN RESEMBLING ANTI-TJA TO THREATENED ABORTION IN WESTERN AUSTRALIA.
Abscess
Loss of hemolysin expression in Staphylococcus aureus agr mutants correlates with selective survival during mixed infections in murine abscesses and wounds.
Acantholysis
In vivo blockade of pemphigus vulgaris acantholysis by inhibition of intracellular signal transduction cascades.
Acidosis
Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts.
Acidosis
Evidence for the involvement of protein kinase C in acidic pH-induced contraction in spontaneously hypertensive rat aorta.
Acne Vulgaris
Enzyme production of propionibacteria from patients with acne vulgaris and healthy persons.
Acquired Immunodeficiency Syndrome
Pisiform ligament complex syndrome and pisotriquetral arthrosis.
Acquired Immunodeficiency Syndrome
[Antioxidant and/or free radical scavenger vitamins in tropical medicine]
Acquired Immunodeficiency Syndrome
[IgM cryoagglutinin with biphasic hemolysin activity in a patient with AIDS]
Acute Coronary Syndrome
Ticagrelor, a platelet aggregation inhibitor for the potential prevention and treatment of arterial thrombosis and acute coronary syndromes.
Acute Kidney Injury
REVERSAL OF CISPLATIN-INDUCED CARNITINE DEFICIENCY AND ENERGY STARVATION BY PROPIONYL-l-CARNITINE IN RAT KIDNEY TISSUES.
Acute Lung Injury
E. coli hemolysin-induced lipid mediator metabolism in alveolar macrophages: impact of eicosapentaenoic acid.
Adenocarcinoma
A Rare Case of Progressive Dyspnea and Bilateral Lung Infiltration in a Young Male.
Adenocarcinoma
Clinical relevance of intraoperative pleural lavage cytology in non-small cell lung cancer.
Adenocarcinoma
Enhanced production of phospholipase C and perfringolysin O (alpha and theta toxins) in a gatifloxacin-resistant strain of Clostridium perfringens.
Adenocarcinoma
Gastric adenocarcinoma revealed by atypical pulmonary lymphangitic carcinomatosis.
Adenocarcinoma
Low PLCE1 levels are correlated with poor prognosis in hepatocellular carcinoma.
Adenocarcinoma
Noteworthy prognostic value of phospholipase C delta genes in early stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy and potential molecular mechanisms.
Adenocarcinoma
Novel genetic variants in genes of the Fc gamma receptor-mediated phagocytosis pathway predict non-small cell lung cancer survival.
Adenocarcinoma
Peritoneal wash cytology in gastric carcinoma. Prognostic significance and therapeutic consequences.
Adenocarcinoma
Pharbilignan C induces apoptosis through a mitochondria-mediated intrinsic pathway in human breast cancer cells.
Adenocarcinoma
Phospholipase C activity in human endometrium: its significance in endometrial pathology.
Adenocarcinoma
Phospholipase C delta2 expression characterizes the neoplastic transformation of the human gastric mucosa.
Adenocarcinoma
Pleural lavage cytology immediately after thoracotomy and before closure of the thoracic cavity for lung cancer without pleural effusion and dissemination: clinicopathologic and prognostic analysis.
Adenocarcinoma
Positive Intraoperative Peritoneal Lavage Cytology is a Negative Prognostic Factor in Pancreatic Ductal Adenocarcinoma: A Retrospective Single-Center Study.
Adenocarcinoma
Prognostic value of intraoperative pleural lavage cytology for lung cancer without carcinomatous pleuritis: importance in patients with early stage disease during long-term follow-up.
Adenocarcinoma
Pulmonary lymphangitic carcinomatosis from head and neck squamous cell carcinoma.
Adenocarcinoma
Pulmonary lymphangitic carcinomatosis from metastatic gastric adenocarcinoma: case report.
Adenocarcinoma
Pulmonary lymphangitis carcinomatosis: systematic review and meta-analysis of case reports, 1970-2018.
Adenocarcinoma
Recurrence patterns in patients with early stage non-small cell lung cancers undergoing positive pleural lavage cytology.
Adenocarcinoma
Relevance of Intraoperative Pleural Lavage Cytology and Histologic Subtype in Lung Adenocarcinoma.
Adenocarcinoma
Role of pleural lavage cytology before resection for primary lung carcinoma.
Adenocarcinoma
Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues.
Adenocarcinoma
Squamous cell lung cancer presenting with pulmonary lymphangitic carcinomatosis.
Adenocarcinoma of Lung
Efficacy of adjuvant chemotherapy for lung adenocarcinoma patients with positive pleural lavage cytology findings.
Adenocarcinoma of Lung
Impact of genetic alterations on outcomes of patients with stage I nonsmall cell lung cancer: An analysis of the cancer genome atlas data.
Adenocarcinoma of Lung
Phosphoinositide specific phospholipase C?1 inhibition-driven autophagy caused cell death in human lung adenocarcinoma A549 cells in vivo and in vitro.
Adenocarcinoma of Lung
PLC?1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia.
Adenocarcinoma of Lung
Relevance of Intraoperative Pleural Lavage Cytology and Histologic Subtype in Lung Adenocarcinoma.
Adenoma
Phorbol ester, not growth hormone releasing factor, consistently stimulates growth hormone release from somatotroph adenomas in culture.
Adenoma
Thyroid-stimulating hormone activates phospholipase C in normal and neoplastic thyroid tissue.
Adenomatous Polyposis Coli
Growth inhibition by phospholipase C inhibitor peptides of colorectal carcinoma cells derived from familial adenomatous polyposis.
Adenomatous Polyposis Coli
Molecular profiling of isolated histological components of wilms tumor implicates a common role for the Wnt signaling pathway in kidney and tumor development.
Adenomatous Polyposis Coli
Phospholipase C?1 represses colorectal cancer growth by inhibiting the Wnt/?-catenin signaling axis.
Agammaglobulinemia
Hypermorphic mutation of phospholipase C, ?2 acquired in ibrutinib-resistant CLL confers BTK independency upon B-cell receptor activation.
Agranulocytosis
In vivo effects of intravascularly applied Escherichia coli hemolysin: dissociation between induction of granulocytopenia and lethality in monkeys.
Airway Obstruction
Clinical aspects of type 1 posterior laryngeal clefts: literature review and a report of 31 patients.
Alopecia
Alopecia in a viable phospholipase C delta 1 and phospholipase C delta 3 double mutant.
Alzheimer Disease
A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.
Alzheimer Disease
Alteration of phospholipase C-delta protein level and specific activity in Alzheimer's disease.
Alzheimer Disease
Alterations in muscarinic receptor-coupled phosphoinositide hydrolysis and AP-1 activation in Alzheimer's disease cybrid cells.
Alzheimer Disease
Alzheimer's disease related peptides affected cholinergic receptor mediated poly(ADP-ribose) polymerase activity in the hippocampus.
Alzheimer Disease
Alzheimer's-associated PLC?2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia.
Alzheimer Disease
Amyloid beta protein (25-35) stimulation of phospholipase C in LA-N-2 cells.
Alzheimer Disease
Amyloid beta protein disruption of cholinergic and growth factor phospholipase C signals could underlie cognitive and neurodegerative aspects of Alzheimer's disease.
Alzheimer Disease
Changes in platelet phospholipase C protein level and activity in Alzheimer's disease.
Alzheimer Disease
Cholinergic and serotonergic stimulation of phosphoinositide hydrolysis is decreased in Alzheimer's disease.
Alzheimer Disease
Cholinergic stimulation of AP-1 and NF kappa B transcription factors is differentially sensitive to oxidative stress in SH-SY5Y neuroblastoma: relationship to phosphoinositide hydrolysis.
Alzheimer Disease
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.
Alzheimer Disease
Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.
Alzheimer Disease
Differential expression profiles of PLC-beta1 and -delta1 in primary cultured rat cortical neurons treated with N-methyl-D-aspartate and peroxynitrite.
Alzheimer Disease
Differential involvement of phospholipase C isozymes in Alzheimer's disease.
Alzheimer Disease
Diminished muscarinic receptor-stimulated [3H]-PIP2 hydrolysis in Alzheimer's disease.
Alzheimer Disease
Examination of the Effect of Rare Variants in TREM2, ABI3, and PLCG2 in LOAD Through Multiple Phenotypes.
Alzheimer Disease
Fluorogenic XY-69 in Lipid Vesicles for Measuring Activity of Phospholipase C Isozymes.
Alzheimer Disease
Glutamate-induced antigenic changes of phospholipase C-delta in cultured cortical neurons.
Alzheimer Disease
Identification of Risk Pathways and Functional Modules for Coronary Artery Disease Based on Genome-wide SNP Data.
Alzheimer Disease
Loss of stimulatory effect of guanosine triphosphate on [(35)S]GTPgammaS binding correlates with Alzheimer's disease neurofibrillary pathology in entorhinal cortex and CA1 hippocampal subfield.
Alzheimer Disease
Phosphatidylinositol-specific phospholipase C activity in the postmortem human brain: no alteration in Alzheimer's disease.
Alzheimer Disease
Phosphoinositide hydrolysis, G alpha q, phospholipase C, and protein kinase C in post mortem human brain: effects of post mortem interval, subject age, and Alzheimer's disease.
Alzheimer Disease
Phospholipase C isozymes in the human brain and their changes in Alzheimer's disease.
Alzheimer Disease
PLCG2 rs72824905 Variant Reduces the Risk of Alzheimer's Disease and Multiple Sclerosis.
Alzheimer Disease
Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening.
Alzheimer Disease
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
Alzheimer Disease
Reduction of platelet phospholipase C activity in patients with Alzheimer disease.
Alzheimer Disease
Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease.
Amebiasis
Antibodies against Entamoeba histolytica hemolysin HLY4 in sera from patients with invasive amebiasis.
Amyotrophic Lateral Sclerosis
Investigating the neuroanatomical substrate of pathological laughing and crying in amyotrophic lateral sclerosis with multimodal neuroimaging techniques.
Amyotrophic Lateral Sclerosis
Pathological laughing and crying in amyotrophic lateral sclerosis is related to frontal cortex function.
Anaphylaxis
MRGPRX2 is essential for sinomenine hydrochloride induced anaphylactoid reactions.
Anaplasia
[Evaluation of the results of fine-needle aspiration liver biopsies and the complications in 2528 cases.]
Anemia
Erythrocyte lysis and Xenopus laevis oocyte rupture by recombinant Plasmodium falciparum hemolysin III.
Anemia
Evaluation of clinical characteristics, diagnostic test results, and outcome in horses with internal infection caused by Corynebacterium pseudotuberculosis: 30 cases (1995-2003).
Anemia
Studies on leukemic leukocyte extracts. I. Lack of antigenic relationship in acquired hemolytic anemia. II. The demonstration of a hemolysin and agglutinin.
Anemia
THE PRESENCE OF A WEAK HEMOLYSIN IN THE HOOK WORM AND ITS RELATION TO THE ANEMIA OF UNCINARIASIS.
Anemia, Hemolytic
Biphasic hemolysin hemolytic anemia: reappraisal of an acute immune hemolytic anemia of infancy and childhood.
Anemia, Hemolytic
Donath-Landsteiner hemolytic anemia due to an anti-Pr-like biphasic hemolysin.
Anemia, Hemolytic
Hemolysins in acquired hemolytic anemia; effect of pH on the activity in vitro of a serum hemolysin.
Anemia, Hemolytic
Studies on leukemic leukocyte extracts. I. Lack of antigenic relationship in acquired hemolytic anemia. II. The demonstration of a hemolysin and agglutinin.
Anemia, Hemolytic
[Acquired hemolytic anemia with incomplete cold agglutinins of extraordinarily high titer and cold acid hemolysin.]
Anemia, Hemolytic
[Case of acute hemolytic anemia in a young child with presence of immunological hemolysin & anticomplement property of the blood.]
Anemia, Hemolytic
[Hemolytic anemia under the effect of atypical agglutinin and hemolysin.]
Anemia, Hemolytic, Autoimmune
Acute autoimmune hemolytic anemia due to a low molecular weight IgM cold hemolysin associated with episodic lymphoid granulomatous vasculitis.
Anemia, Hemolytic, Autoimmune
Autoimmune hemolytic anemia with concurrence of warm and cold red cell autoantibodies and a warm hemolysin.
Anemia, Hemolytic, Autoimmune
Autoimmune hemolytic anemia with hemoglobinemia and hemoglobinuria in the absence of a demonstrable hemolysin or complement-binding antibody.
Anemia, Hemolytic, Autoimmune
Rituximab as successful therapy in a patient with refractory paroxysmal cold hemoglobinuria.
Anemia, Sickle Cell
[Antioxidant and/or free radical scavenger vitamins in tropical medicine]
Aneurysm
Analysis of phospholipase C gene in patients with subarachnoid hemorrhage due to ruptured intracranial saccular aneurysm.
Aneurysm
Novel evidence of PLC delta2 involvement in the regulation of the differential evolution of human aneurysms.
Aneurysm
The effect of inlet waveforms on computational hemodynamics of patient-specific intracranial aneurysms.
Aneurysm, Ruptured
Novel evidence of PLC delta2 involvement in the regulation of the differential evolution of human aneurysms.
Angioedema
Association study of genetic variants in PLA2G4A, PLCG1, LAT, SYK, and TNFRS11A genes in NSAIDs-induced urticaria and/or angioedema patients.
Angioid Streaks
Ultra-Widefield Imaging in Patients with Angioid Streaks Secondary to Pseudoxanthoma Elasticum.
Anthrax
Activation of phospholipase C and protein kinase C is required for expression of anthrax lethal toxin cytotoxicity in J774A.1 cells.
Anthrax
Adaptation of the endogenous Salmonella enterica serovar Typhi clyA-encoded hemolysin for antigen export enhances the immunogenicity of anthrax protective antigen domain 4 expressed by the attenuated live-vector vaccine strain CVD 908-htrA.
Anthrax
Bacillus anthracis phospholipases C facilitate macrophage-associated growth and contribute to virulence in a murine model of inhalation anthrax.
Aortic Valve Insufficiency
Transcatheter JenaValve Implantation in a Stentless Prosthesis: A Challenging Case After 4 Previous Aortic Procedures.
Aphakia
Signalling through phospholipase C beta 4 is not essential for midbrain dopaminergic neuron survival.
Aphasia
Pathological laughter as prodromal manifestation of transient ischemic attacks--case report and brief review.
Arrhythmias, Cardiac
Phospholipase C inhibitors attenuate arrhythmias induced by kappa-receptor stimulation in the isolated rat heart.
Arrhythmias, Cardiac
Pro- and anti-arrhythmic effects of a kappa opioid receptor agonist: a model for the biphasic action of a local hormone in the heart.
Arthritis
A novel ENU-induced mutation in Phospholipase C gamma 2 causes inflammatory arthritis, metabolic defects, and in vitro male infertility in the mouse.
Arthritis
Anti-inflammatory and immunosuppressive activities of 1,3-dicyclopentyl-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylic acid diethyl ester (ZL-5015).
Arthritis
CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis.
Arthritis
Phospholipase C gamma 2 is critical for development of a murine model of inflammatory arthritis by affecting actin dynamics in dendritic cells.
Arthritis
Targeted inhibition of phospholipase C gamma 2 adapter function blocks osteoclastogenesis and protects from pathological osteolysis.
Arthritis, Rheumatoid
Agglutination in rheumatoid arthritis serum of sheep cells sensitized with hemolysin and infectious mononucleosis agglutinins.
Arthritis, Rheumatoid
Ofatumumab, a human monoclonal antibody for lymphoid malignancies and autoimmune disorders.
Arthritis, Rheumatoid
Quantitative immunodetection of key elements of polyphosphoinositide signal transduction in osteoblasts from arthritic patients shows a direct correlation with cell proliferation.
Arthritis, Rheumatoid
Rheumatoid factor-producing cells detected by direct hemolytic plaque assay.
Arthritis, Rheumatoid
Viral antibody titers. Comparison in patients with multiple sclerosis and rheumatoid arthritis.
Asthma
Admixture mapping of asthma in southwestern Europeans with North African ancestry influences.
Astrocytoma
2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists.
Astrocytoma
4-Alkyloxyimino Derivatives of Uridine-5'-Triphosphate: Distal Modification of Potent Agonists as a Strategy for Molecular Probes of P2Y2, P2Y4 and P2Y6 Receptors.
Astrocytoma
A guanine nucleotide-independent inwardly rectifying cation permeability is associated with P2Y1 receptor expression in Xenopus oocytes.
Astrocytoma
A molecularly identified P2Y receptor simultaneously activates phospholipase C and inhibits adenylyl cyclase and is nonselectively activated by all nucleoside triphosphates.
Astrocytoma
Acyclic analogues of adenosine bisphosphates as P2Y receptor antagonists: phosphate substitution leads to multiple pathways of inhibition of platelet aggregation.
Astrocytoma
Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists.
Astrocytoma
Adenosine inhibits histamine-induced phosphoinositide hydrolysis mediated via pertussis toxin-sensitive G protein in human astrocytoma cells.
Astrocytoma
An arginine/glutamine difference at the juxtaposition of transmembrane domain 6 and the third extracellular loop contributes to the markedly different nucleotide selectivities of human and canine P2Y11 receptors.
Astrocytoma
Cross-talk between phospholipase C and phosphoinositide 3-kinase signalling pathways.
Astrocytoma
CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors.
Astrocytoma
Decrease in thromboxane A2 receptor expression by differentiation with dibutyryl cyclic AMP in 1321N1 human astrocytoma cells.
Astrocytoma
Design and synthesis of new bicyclic diketopiperazines as scaffolds for receptor probes of structurally diverse functionality.
Astrocytoma
Differential coupling of the human P2Y(11) receptor to phospholipase C and adenylyl cyclase.
Astrocytoma
Expression of phosphoinositide-specific phospholipase C isoenzymes in cultured astrocytes.
Astrocytoma
GTP gamma S binding activities were reduced in heavy membrane fraction during desensitization by Ca-mobilizing agonists in human astrocytoma cells.
Astrocytoma
Identification of a B2-bradykinin receptor linked to phospholipase C and inhibition of dopamine stimulated cyclic AMP accumulation in the human astrocytoma cell line D384.
Astrocytoma
Inhibition of beta(2)-adrenergic and muscarinic cholinergic receptor endocytosis after depletion of phosphatidylinositol bisphosphate.
Astrocytoma
Involvement of phosphatidylcholine-specific phospholipase C in thromboxane A2-induced activation of mitogen-activated protein kinase in astrocytoma cells.
Astrocytoma
Mastoparan inhibits phosphoinositide hydrolysis via pertussis toxin-insensitive [corrected] G-protein in human astrocytoma cells.
Astrocytoma
Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors.
Astrocytoma
Modulation of cyclic AMP accumulation in glial cells by exogenous phospholipase C.
Astrocytoma
Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase.
Astrocytoma
ONO NT-126 is a potent and selective thromboxane A2 antagonist in human astrocytoma cells.
Astrocytoma
Pharmacological and second messenger signalling selectivities of cloned P2Y receptors.
Astrocytoma
Phospholipase C, protein kinase C, Ca2+/calmodulin-dependent protein kinase II, and redox state are involved in epigallocatechin gallate-induced phospholipase D activation in human astroglioma cells.
Astrocytoma
Protein kinase C mediates delayed inhibitory feedback regulation of human neurokinin type 1 receptor activation of phospholipase C in UC11 astrocytoma cells.
Astrocytoma
Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate ?-ester modifications as selective agonists of the P2Y(4) receptor.
Astrocytoma
Signaling of the Human P2Y(1) Receptor Measured by a Yeast Growth Assay with Comparisons to Assays of Phospholipase C and Calcium Mobilization in 1321N1 Human Astrocytoma Cells.
Astrocytoma
Synthesis of pyridoxal phosphate derivatives with antagonist activity at the P2Y13 receptor.
Astrocytoma
The mechanism of muscarinic receptor-stimulated phosphatidylinositol resynthesis in 1321N1 astrocytoma cells and its inhibition by Li+.
Astrocytoma
Thromboxane A2 activates phospholipase C in astrocytoma cells via pertussis toxin-insensitive G-protein.
Ataxia
The rat phospholipase C beta 4 gene is expressed at high abundance in cerebellar Purkinje cells.
Atherosclerosis
CK beta 8/CCL23 induces cell migration via the Gi/Go protein/PLC/PKC delta/NF-kappa B and is involved in inflammatory responses.
Atherosclerosis
D609 inhibits progression of preexisting atheroma and promotes lesion stability in apolipoprotein e-/- mice: a role of phosphatidylcholine-specific phospholipase in atherosclerosis.
Atherosclerosis
Development of a liquid chromatography-mass spectrometry based enzyme activity assay for phosphatidylcholine-specific phospholipase C.
Atherosclerosis
Endothelin-1 signalling in vascular smooth muscle: pathways controlling cellular functions associated with atherosclerosis.
Atherosclerosis
Lipopolysaccharide activated phosphatidylcholine-specific phospholipase C and induced IL-8 and MCP-1 production in vascular endothelial cells.
Atherosclerosis
MiR-30s Family inhibit the Proliferation and Apoptosis in Human Coronary Artery Endothelial Cells through Targeting the 3'UTR Region of ITGA4 and PLCG1.
Atherosclerosis
Pharmacological effects and clinical applications of propionyl-L-carnitine.
Atherosclerosis
Phosphatidylethanolamine binding protein 1 in vacular endothelial cell autophagy and atherosclerosis.
Atherosclerosis
Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice.
Atherosclerosis
Propolis Reduces Phosphatidylcholine-Specific Phospholipase C Activity and Increases Annexin a7 Level in Oxidized-LDL-Stimulated Human Umbilical Vein Endothelial Cells.
Atherosclerosis
Protein corona and phospholipase activity drive selective accumulation of nanomicelles in atherosclerotic plaques.
Atherosclerosis
Targeting annexin A7 by a small molecule suppressed the activity of phosphatidylcholine-specific phospholipase C in vascular endothelial cells and inhibited atherosclerosis in apolipoprotein E(-/-) mice.
Atherosclerosis
Targeting phosphatidylcholine-specific phospholipase C for atherogenesis therapy.
Atrial Fibrillation
Implantable cardiac monitors to detect atrial fibrillation after cryptogenic stroke: a systematic review and economic evaluation.
Autoimmune Diseases
Ofatumumab, a human monoclonal antibody for lymphoid malignancies and autoimmune disorders.
Autoimmune Diseases
PLAID syndrome: Characteristic presentation and a novel therapeutic option.
Bacteremia
A subset of two adherence systems, acute pro-inflammatory pap genes and invasion coding dra, fim, or sfa, increases the risk of Escherichia coli translocation to the bloodstream.
Bacteremia
Association between the presence of enterococcal virulence factors gelatinase, hemolysin, and enterococcal surface protein and mortality among patients with bacteremia due to Enterococcus faecalis.
Bacteremia
Bacterial and host factors affecting Pseudomonas aeruginosa colonization versus bacteremia in granulocytopenic patients.
Bacteremia
Comparative Prevalence of Virulence Factors in Escherichia coli Causing Urinary Tract Infection in Male Infants with and without Bacteremia.
Bacteremia
Differential gene expression in Streptococcus pneumoniae in response to various iron sources.
Bacteremia
Dissemination and Systemic Colonization of Uropathogenic Escherichia coli in a Murine Model of Bacteremia.
Bacteremia
The role of genomic islands in Escherichia coli K1 interactions with intestinal and kidney epithelial cells.
Bacterial Infections
A Salmonella inositol polyphosphatase acts in conjunction with other bacterial effectors to promote host cell actin cytoskeleton rearrangements and bacterial internalization.
Bacterial Infections
Detection of phospholipase C in nontuberculous mycobacteria and its possible role in hemolytic activity.
Bacterial Infections
Evaluation of a Rapid Point-of-Care Multiplex Immunochromatographic Assay for the Diagnosis of Enteric Fever.
Bacterial Infections
Induction of histamine release from rat mast cells and human basophilic granulocytes by clinical Escherichia coli isolates and relation to hemolysin production and adhesin expression.
Bacterial Infections
Phospholipase C and diacylglycerol lipase in human gallbladder and hepatic bile.
Bacterial Infections
PLAID: a Syndrome of Complex Patterns of Disease and Unique Phenotypes.
Bacterial Infections
TTSS2-deficient hha mutant of Salmonella Typhimurium exhibits significant systemic attenuation in immunocompromised hosts.
Bacteriuria
Expression and detection of pap-, sfa-, and afa-encoded fimbrial adhesin systems among uropathogenic Escherichia coli.
Bacteriuria
Hemagglutination of human type O erythrocytes, hemolysin production, and serogrouping of Escherichia coli isolates from patients with acute pyelonephritis, cystitis, and asymptomatic bacteriuria.
Bernard-Soulier Syndrome
Phospholipase C activity in platelets from Bernard-Soulier syndrome patients.
Bernard-Soulier Syndrome
What's new in using platelet research? To unravel thrombopathies and other human disorders.
Blister
Ca2+ signalling is critical for autoantibody-induced blistering of human epidermis in pemphigus.
Blister
Human umbilical vein endothelial cells (HUVECs) show Ca(2+) mobilization as well as Ca(2+) influx upon hypoxia.
Blister
Reversible bleb formation in mast cells stimulated with antigen is Ca2+-calmodulin -dependent and bleb size is regulated by ARF6.
Blister
[Comparative studies on the hemolysin titer in blister fluid and blood and its usefulness for testing capillary permeability.]
Bone Resorption
Antiresorptive activity of bacillus-fermented antler extracts: inhibition of osteoclast differentiation.
Bone Resorption
Detection and characterization of endothelin in transformed human osteoblast cell culture medium.
Bone Resorption
Phospholipase C signaling activated by parathyroid hormone mediates the rapid osteoclastogenesis in the fracture healing of orchiectomized mice.
Brain Diseases
Phospholipase C beta 1 deficiency is associated with early-onset epileptic encephalopathy.
Brain Diseases
Severe infantile epileptic encephalopathy due to mutations in PLCB1: expansion of the genotypic and phenotypic disease spectrum.
Brain Diseases
Three novel patients with epileptic encephalopathy due to biallelic mutations in the PLCB1 gene.
Brain Edema
Evidence for the role of phosphatidylcholine-specific phospholipase in experimental subarachnoid hemorrhage in rats.
Brain Injuries
Inhibition of phospholipase C with neomycin improves metabolic and neurologic outcome following traumatic brain injury.
Brain Injuries
Regional activities of phospholipase C after experimental brain injury in the rat.
Brain Injuries
Regional levels of phospholipase Cgamma after fluid percussion brain injury in the rat.
Brain Injuries
Relationship between opioids and activation of phospholipase C and protein kinase C in brain injury induced pial artery vasoconstriction.
Brain Injuries, Traumatic
Alterations in phosphatidylcholine metabolism of stretch-injured cultured rat astrocytes.
Brain Injuries, Traumatic
Du rire aux larmes: pathological laughing and crying in patients with traumatic brain injury and treatment with lamotrigine.
Brain Injuries, Traumatic
Inhibition of phospholipase C with neomycin improves metabolic and neurologic outcome following traumatic brain injury.
Brain Ischemia
CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke.
Brain Ischemia
Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders.
Brain Ischemia
Cytidine 5'-diphosphocholine (CDP-choline) in stroke and other CNS disorders.
Brain Ischemia
Differential effects of phospholipase inhibitors on free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury.
Brain Ischemia
G protein-dependent activation of phospholipase C by adenosine A3 receptors in rat brain.
Brain Ischemia
Immunohistochemical expression of phospholipase C in global and focal ischemic encephalopathy in gerbil: relationship with morphological changes.
Brain Ischemia
Prolonged ischemia differently affects phospholipase C acting against phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate in brain subsynaptosomal fraction.
Brain Ischemia
Synaptic vesicle-bound phospholipase(s) acting on phosphatidylinositol exhibit(s) high susceptibility to brain ischemia.
Brain Ischemia
[Effect of phenylmethylsulfonyl fluoride (PMSF) on brain tissue arachidonic acid and extracellular glutamate level in complete cerebral ischemia in rats]
Brain Ischemia
[Polyphosphoinositide metabolism in temporary cerebral ischemia--the reversibility after recirculation]
Brain Neoplasms
Targeting Brain-Adaptive Cancer Stem Cells Prohibits Brain Metastatic Colonization of Triple-Negative Breast Cancer.
Brain Stem Neoplasms
Investigation of I1-imidazoline receptors using microphysiometry and molecular modelling.
Breast Neoplasms
A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density.
Breast Neoplasms
Activation of Phosphatidylcholine-Specific Phospholipase C in Breast and Ovarian Cancer: Impact on MRS-Detected Choline Metabolic Profile and Perspectives for Targeted Therapy.
Breast Neoplasms
Akt interaction with PLC(gamma) regulates the G(2)/M transition triggered by FGF receptors from MDA-MB-231 breast cancer cells.
Breast Neoplasms
Comparative evaluation of in vitro cytotoxic effects among parent abietyl alcohol and novel fatty acid ester derivatives against MCF7 and hepatocellular carcinoma cell lines.
Breast Neoplasms
EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells.
Breast Neoplasms
Expression of phospholipase C isozymes in human breast cancer and their clinical significance.
Breast Neoplasms
First report of an anti-tumor, anti-fungal, anti-yeast and anti-bacterial hemolysin from Albizia lebbeck seeds.
Breast Neoplasms
Heregulinbeta activates store-operated Ca2+ channels through c-erbB2 receptor level-dependent pathway in human breast cancer cells.
Breast Neoplasms
Human-derived osteoblast-like cells and pericyte-like cells induce distinct metastatic phenotypes in primary breast cancer cells.
Breast Neoplasms
Identification of genes and pathways associated with MDR in MCF-7/MDR breast cancer cells by RNA-seq analysis.
Breast Neoplasms
Induction of cancer cell migration by epidermal growth factor is initiated by specific phosphorylation of tyrosine 1248 of c-erbB-2 receptor via EGFR.
Breast Neoplasms
Inhibition of phosphatidylcholine-specific phospholipase C downregulates HER2 overexpression on plasma membrane of breast cancer cells.
Breast Neoplasms
Inhibition of phosphatidylcholine-specific phospholipase C results in loss of mesenchymal traits in metastatic breast cancer cells.
Breast Neoplasms
Involvement of phospholipase C in heat-shock-induced phosphorylation of P-glycoprotein in multidrug resistant human breast cancer cells.
Breast Neoplasms
miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer.
Breast Neoplasms
Molecular causes of the aberrant choline phospholipid metabolism in breast cancer.
Breast Neoplasms
Molecular profiling pleomorphic lobular carcinomas of the breast: evidence for a common molecular genetic pathway with classic lobular carcinomas.
Breast Neoplasms
Nonprotecting Group Synthesis of a Phospholipase C Activatable Probe with an Azo-Free Quencher.
Breast Neoplasms
Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40.
Breast Neoplasms
Outcomes of pleomorphic lobular carcinoma versus invasive lobular carcinoma.
Breast Neoplasms
Phosphatidylcholine-specific phospholipase C inhibition reduces HER2-overexpression, cell proliferation and in vivo tumor growth in a highly tumorigenic ovarian cancer model.
Breast Neoplasms
Phospholipase C-beta 2 promotes mitosis and migration of human breast cancer-derived cells.
Breast Neoplasms
Phospholipase C-protein kinase C mediated phospholipase D activation pathway is involved in tamoxifen induced apoptosis.
Breast Neoplasms
PLC-beta2 is highly expressed in breast cancer and is associated with a poor outcome: a study on tissue microarrays.
Breast Neoplasms
Pleomorphic lobular carcinoma of the breast: a comparison of cytopathological features with other lobular carcinoma variants.
Breast Neoplasms
Postpartum remodeling, lactation, and breast cancer risk: summary of a National Cancer Institute-sponsored workshop.
Breast Neoplasms
Rapid and long-term effects of 17 beta-estradiol on PIP2-phospholipase C-specific activity of MCF-7 cells.
Breast Neoplasms
Rebuttal to Letter-to-Editor on 'Distinction between PC-PLC and PI-PLC needs clarification' received for our manuscript titled "Diospyrin derivative, an anticancer quinonoid, regulates apoptosis at endoplasmic reticulum as well as mitochondria by modulating cytosolic calcium in human breast carcinoma cells" [BBRC 417 (2012) 903-909].
Breast Neoplasms
Relationship of growth stimulated by lithium, estradiol, and EGF to phospholipase C activity in MCF-7 human breast cancer cells.
Breast Neoplasms
Synthesis of fluorescent gold nanodot-liposome hybrids for detection of phospholipase C and its inhibitor.
Breast Neoplasms
Targetable alterations in invasive pleomorphic lobular carcinoma of the breast.
Breast Neoplasms
Targeting Metabolic Reprogramming to Improve Breast Cancer Treatment: An In Vitro Evaluation of Selected Metabolic Inhibitors Using a Metabolomic Approach.
Breast Neoplasms
Thiazolidinedione or Rhodanine: A Study on Synthesis and Anticancer Activity Comparison of Novel Thiazole Derivatives.
Breast Neoplasms
Trichostatin A reduced phospholipase C gamma-1 transcript and protein contents in MCF-7 breast cancer cells.
Breast Neoplasms
[Clinical features and diagnosis of pulmonary lymphaugitic carcinomatosis.]
Bronchitis
Preliminary evaluation of the haemagglutination and haemagglutination inhibition tests for avian infectious bronchitis virus.
Bronchopulmonary Dysplasia
Periventricular leukomalacia complex. Clinical and pathologic correlates.
Candidemia
Antifungal Susceptibility in Serum and Virulence Determinants of Candida Bloodstream Isolates from Hong Kong.
Candidiasis
Comparative Study of Esterase and Hemolytic Activities in Clinically Important Candida Species, Isolated From Oral Cavity of Diabetic and Non-diabetic Individuals.
Candidiasis
Intradural cauda equina Candida abscess presenting with hydrocephalus: case report.
Carcinogenesis
A TNFR2-hnRNPK Axis Promotes Primary Liver Cancer Development via Activation of YAP Signaling in Hepatic Progenitor Cells.
Carcinogenesis
Advanced-stage mycosis fungoides: role of the signal transducer and activator of transcription 3, nuclear factor-?B and nuclear factor of activated T cells pathways.
Carcinogenesis
Antitumour effects on human colorectal carcinomas cells by stable silencing of phospholipase C-gamma 1 with lentivirus-delivered siRNA.
Carcinogenesis
Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.
Carcinogenesis
Development of 2-Morpholino-N-hydroxybenzamides as anti-proliferative PC-PLC inhibitors.
Carcinogenesis
Development of a liquid chromatography-mass spectrometry based enzyme activity assay for phosphatidylcholine-specific phospholipase C.
Carcinogenesis
EGFR overexpression in canine primary lung cancer: pathogenetic implications and impact on survival.
Carcinogenesis
Exclusion of the phosphatidylinositol-specific phospholipase C beta 3 (PLC beta 3) gene as candidate for the multiple endocrine neoplasia type 1 (MEN 1) gene.
Carcinogenesis
Expression of phospholipases gamma 1, beta 1, and delta 1 in primary human colon carcinomas and colon carcinoma cell lines.
Carcinogenesis
Hyperparathyroidism of multiple endocrine neoplasia type 1: candidate gene and parathyroid calcium sensing protein expression.
Carcinogenesis
Hypolipidemic effect of ginger in 1,2-dimethyl hydrazine-induced experimental colon carcinogenesis.
Carcinogenesis
miR-423-5p inhibits the proliferation and metastasis of glioblastoma cells by targeting phospholipase C beta 1.
Carcinogenesis
Mucins: the Old, the New and the Promising Factors in Hepatobiliary Carcinogenesis.
Carcinogenesis
Oncogenic role of phospholipase C-?1 in progression of hepatocellular carcinoma.
Carcinogenesis
Phospholipase C?1 represses colorectal cancer growth by inhibiting the Wnt/?-catenin signaling axis.
Carcinogenesis
Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis.
Carcinogenesis
Postpartum remodeling, lactation, and breast cancer risk: summary of a National Cancer Institute-sponsored workshop.
Carcinogenesis
Quantitative proteomics analysis of sporadic parathyroid adenoma tissue samples.
Carcinogenesis
Recent advances in understanding the molecular role of phosphoinositide-specific phospholipase C gamma 1 as an emerging onco-driver and novel therapeutic target in human carcinogenesis.
Carcinogenesis
Tumor suppressor role of phospholipase C{varepsilon} in Ras-triggered cancers.
Carcinogenesis
Up-regulated expression of phospholipase C, ?1 is associated with tumor cell proliferation and poor prognosis in hepatocellular carcinoma.
Carcinogenesis
Whole-exome mutational and transcriptional landscapes of combined hepatocellular cholangiocarcinoma and intrahepatic cholangiocarcinoma reveal molecular diversity.
Carcinogenesis
Wilson disease, ABCC2 c.3972C > T polymorphism and primary liver cancers: suggestions from a familial cluster.
Carcinogenesis
[Cytoplasmic membrane phospholipid content and phospholipase C activity in rat epithelial cell under colitis-associated carcinogenesis]
Carcinogenesis
[Dendritic cell vaccine modified by murine mAFP gene enhances immunoprotective effect on liver carcinogenesis and tumor development in mice]
Carcinogenesis
[Longitudinal study of aflatoxin exposure in the development of primary liver cancer in patients with chronic hepatitis].
Carcinogenesis
[Molecular markers and mechanisms for stemness maintenance of liver cancer stem cells: a review].
Carcinogenesis
[Serum glycoprotein profiling by lectin affinity microarray to distinguish the various stages of primary liver carcinogenesis].
Carcinoid Tumor
Breast cancer cutaneous metastases mimicking Papilloma Cutis Lymphostatica. Biopsy to avoid pitfalls.
Carcinoma
A case of fatal respiratory failure after surgery for advanced supraglottic laryngeal carcinoma.
Carcinoma
A Comparison of the Pathological Types of Undifferentiated Carcinoma of the Pancreas.
Carcinoma
A Rare Case of Progressive Dyspnea and Bilateral Lung Infiltration in a Young Male.
Carcinoma
Abdominal and gluteofemoral size and risk of liver cancer: The liver cancer pooling project.
Carcinoma
Butyrate-induced alterations of phosphoinositide metabolism, protein kinase C activity and reduced CD44 variant expression in HT-29 colon cancer cells.
Carcinoma
Characterization of a novel tumor-suppressor gene PLC delta 1 at 3p22 in esophageal squamous cell carcinoma.
Carcinoma
Clinical outcome in pleomorphic lobular carcinoma: a case-control study with comparison to classic invasive lobular carcinoma.
Carcinoma
Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein.
Carcinoma
Combined hepatocellular-cholangiocarcinoma: what the radiologist needs to know about biphenotypic liver carcinoma.
Carcinoma
Cytology of pleomorphic lobular carcinoma with apocrine cell differentiation of the breast. A case report.
Carcinoma
Distinct Prognostic Values of Phospholipase C Beta Family Members for Non-Small Cell Lung Carcinoma.
Carcinoma
DU145 human prostate carcinoma invasiveness is modulated by urokinase receptor (uPAR) downstream of epidermal growth factor receptor (EGFR) signaling.
Carcinoma
Effect of guanine and adenine nucleotides on bombesin-stimulated phospholipase C activity in membranes from Swiss 3T3 and small cell lung carcinoma cells.
Carcinoma
Epidermal growth factor regulates topoisomerase II activity and drug sensitivity in human KB cells.
Carcinoma
Expression of MUC1 and its significance in hepatocellular and cholangiocarcinoma tissue.
Carcinoma
Expression of phospholipases gamma 1, beta 1, and delta 1 in primary human colon carcinomas and colon carcinoma cell lines.
Carcinoma
Extent and cost of inappropriate use of tumour markers in patients with pulmonary disease: a multicentre retrospective study in Shanghai, China.
Carcinoma
Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells.
Carcinoma
Hyaluronan-CD44 promotes phospholipase C-mediated Ca2+ signaling and cisplatin resistance in head and neck cancer.
Carcinoma
Identification of a novel phospholipase C family gene at chromosome 2q33 that is homozygously deleted in human small cell lung carcinoma.
Carcinoma
Incidence of primary liver cancer and aetiological aspects: a study of a defined population from a low-endemicity area.
Carcinoma
Inhibition of agonist-induced activation of phospholipase C following poxvirus infection.
Carcinoma
Inhibition of Phosphatidylcholine-Specific Phospholipase C Interferes with Proliferation and Survival of Tumor Initiating Cells in Squamous Cell Carcinoma.
Carcinoma
MicroRNA-34a functions as a tumor suppressor by directly targeting oncogenic PLCE1 in Kazakh esophageal squamous cell carcinoma.
Carcinoma
Mixed pleomorphic lobular and apocrine carcinoma of the breast: A case report suggesting pathogenesis.
Carcinoma
Monitoring Inositol-Specific Phospholipase C Activity Using a Phospholipid FlashPlate(R).
Carcinoma
Noninvasive discrimination of human normal cells and malignant tumor cells by phase-shifting laser microscopy.
Carcinoma
Np63 (p40) Distribution Inside Lung Cancer: A Driver Biomarker Approach to Tumor Characterization.
Carcinoma
P2-purinergic receptor agonists inhibit the growth of androgen-independent prostate carcinoma cells.
Carcinoma
Pemphigus IgG induces expression of urokinase plasminogen activator receptor on the cell surface of cultured keratinocytes.
Carcinoma
Peritoneal Lavage Cytology Following Neoadjuvant Chemotherapy for Gastric Adenocarcinoma: Low Yield in Detecting Peritoneal Metastases.
Carcinoma
Pharmacologic evidence for involvement of phospholipase C in pemphigus IgG-induced inositol 1,4,5-trisphosphate generation, intracellular calcium increase, and plasminogen activator secretion in DJM-1 cells, a squamous cell carcinoma line.
Carcinoma
Phase II study of troxacitabine (BCH-4556) in patients with advanced and/or metastatic renal cell carcinoma: a trial of the National Cancer Institute of Canada-Clinical Trials Group.
Carcinoma
Phospholipase C ?-1 gene polymorphisms and prognosis of esophageal cancer patients from a high-incidence region in northern China.
Carcinoma
Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation.
Carcinoma
Phospholipase C gamma 1 is a potential prognostic biomarker for patients with locally advanced and resectable oral squamous cell carcinoma.
Carcinoma
Phospholipase C gamma 1 regulates the Rap GEF1-Rap1 signalling axis in the control of human prostate carcinoma cell adhesion.
Carcinoma
Phospholipse c inhibitor, u73122, stimulates release of hsp-70 stress protein from A431 human carcinoma cells.
Carcinoma
Pleomorphic lobular carcinoma of the breast: clinicopathologic features of 12 cases.
Carcinoma
Pleomorphic lobular carcinoma of the breast: role of comprehensive molecular pathology in characterization of an entity.
Carcinoma
Preferential inhibition of the platelet-derived growth factor receptor tyrosine kinase by staurosporine.
Carcinoma
Prognostic value of intraoperative pleural lavage cytology for lung cancer without carcinomatous pleuritis: importance in patients with early stage disease during long-term follow-up.
Carcinoma
Pulmonary lymphangitic carcinomatosis from an oropharyngeal squamous cell carcinoma: a case report.
Carcinoma
Pulmonary lymphangitic carcinomatosis from head and neck squamous cell carcinoma.
Carcinoma
Pulmonary lymphangitic carcinomatosis in liver carcinoma: a rare case report and literature review.
Carcinoma
Pure Laparoscopic Versus Open Liver Resection for Primary Liver Carcinoma in Elderly Patients: A Single-Center, Case-Matched Study.
Carcinoma
Recurrence patterns in patients with early stage non-small cell lung cancers undergoing positive pleural lavage cytology.
Carcinoma
Regulation of phosphoinositide hydrolysis induced by histamine and guanine nucleotides in human HeLa carcinoma cells. Calcium and pH dependence and inhibitory role of protein kinase C.
Carcinoma
Role of novel and GWAS originated PLCE1 genetic variants in susceptibility and prognosis of esophageal cancer patients in northern Indian population.
Carcinoma
The influence of hyaluronan-CD44 interaction on topoisomerase II activity and etoposide cytotoxicity in head and neck cancer.
Carcinoma
The inhibitory effect of norepinephrine on the migration of ES-2 ovarian carcinoma cells involves a Rap1-dependent pathway.
Carcinoma
The riminophenazine agents clofazimine and B669 inhibit the proliferation of intrinsically multidrug resistant carcinoma cell lines.
Carcinoma
Thermostable direct hemolysin diminishes tyrosine phosphorylation of epidermal growth factor receptor through protein kinase C dependent mechanism.
Carcinoma
Thermostable direct hemolysin downregulates human colon carcinoma cell proliferation with the involvement of E-cadherin, and ?-catenin/Tcf-4 signaling.
Carcinoma
[Current estimate of the number of patients for liver transplantation with Dutch mortality figures]
Carcinoma
[Effect of EGF on ubiquitination and proteasome-dependent degradation of phospholipase C gamma1 in A431 cells]
Carcinoma in Situ
Pleomorphic lobular carcinoma of the breast: role of comprehensive molecular pathology in characterization of an entity.
Carcinoma, Adenosquamous
Pulmonary lymphangitic carcinomatosis from hypopharyngeal adenosquamous carcinoma.
Carcinoma, Adenosquamous
Recurrence patterns in patients with early stage non-small cell lung cancers undergoing positive pleural lavage cytology.
Carcinoma, Ductal
Apocrine differentiation in invasive pleomorphic lobular carcinoma with in situ ductal and lobular apocrine carcinoma: case report.
Carcinoma, Ductal
Clinicopathological characteristics and survival outcomes in pleomorphic lobular breast carcinoma of the breast: a SEER population-based study.
Carcinoma, Ductal
Fine needle aspiration cytology of pleomorphic lobular carcinoma of the breast. Duct carcinoma as a diagnostic pitfall.
Carcinoma, Ductal
Molecular profiling pleomorphic lobular carcinomas of the breast: evidence for a common molecular genetic pathway with classic lobular carcinomas.
Carcinoma, Ductal
Pancreatic metastasis from invasive pleomorphic lobular carcinoma of the breast: a rare case report.
Carcinoma, Ductal
Pleomorphic lobular carcinoma in pleural fluid: diagnostic pitfall for atypical mesothelial cells.
Carcinoma, Ductal
Pleomorphic lobular carcinoma of the breast: clinicopathologic features of 12 cases.
Carcinoma, Ehrlich Tumor
OXYGEN-STABLE HEMOLYSINS OF GROUP A STREPTOCCI. IV. STUDIES ON THE MECHANISM OF LYSIS BY CELL-BOUND HEMOLYSIN OF RED BLOOD CELLS AND EHRLICH ASCITES TUMOR CELLS.
Carcinoma, Hepatocellular
A prospective cohort study of hepatitis B surface antigen carriers in a working population.
Carcinoma, Hepatocellular
Altered levels of phosphoinositide metabolites and activation of guanine-nucleotide dependent phospholipase C in rat hepatic tumors.
Carcinoma, Hepatocellular
Altered liver ?1-adrenoceptor density and phospholipase C activity in the human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Artemisinin suppresses hepatocellular carcinoma cell growth, migration and invasion by targeting cellular bioenergetics and Hippo-YAP signaling.
Carcinoma, Hepatocellular
beta-estradiol stimulation of DNA synthesis requires different PKC isoforms in HepG2 and MCF7 cells.
Carcinoma, Hepatocellular
Cell-cycle-dependent PC-PLC regulation by APC/C(Cdc20)-mediated ubiquitin-proteasome pathway.
Carcinoma, Hepatocellular
Central liver toxicity after SBRT: An expanded analysis and predictive nomogram.
Carcinoma, Hepatocellular
Characterization of the insulin-like growth factor axis in a human hepatoma cell line (PLC).
Carcinoma, Hepatocellular
Chemotherapeutic agent CPT-11 induces the new expression of the apoptosis initiator to the cytoplasm.
Carcinoma, Hepatocellular
Comparative evaluation of in vitro cytotoxic effects among parent abietyl alcohol and novel fatty acid ester derivatives against MCF7 and hepatocellular carcinoma cell lines.
Carcinoma, Hepatocellular
Comparison of antitumor activity of vitamins K1, K2 and K3 on human tumor cells by two (MTT and SRB) cell viability assays.
Carcinoma, Hepatocellular
Contribution of Hepatitis B, C Virus to Liver Cancer in China North Areas: Experience from Chinese National Cancer Center.
Carcinoma, Hepatocellular
Correlation of Calcium-independent Phosphatidylcholine-specific Phospholipase C with gamma-GT in Hepatoma Cells.
Carcinoma, Hepatocellular
Curcumin suppress the growth of hepatocellular carcinoma via down-regulating
Carcinoma, Hepatocellular
Diagnostic and prognostic value of mRNA expression of phospholipase C ? family genes in hepatitis B virus?associated hepatocellular carcinoma.
Carcinoma, Hepatocellular
Effect of hepatic steatosis on the progression of chronic hepatitis B: A prospective cohort and in vitro study.
Carcinoma, Hepatocellular
Effects of soy isoflavones on apoptosis induction and G2-M arrest in human hepatoma cells involvement of caspase-3 activation, Bcl-2 and Bcl-XL downregulation, and Cdc2 kinase activity.
Carcinoma, Hepatocellular
Enhanced phosphorylation of nuclear 21-kDa and 34-kDa proteins in hepatoma cell death induced by tumor-necrosis factor-alpha.
Carcinoma, Hepatocellular
First report of an anti-tumor, anti-fungal, anti-yeast and anti-bacterial hemolysin from Albizia lebbeck seeds.
Carcinoma, Hepatocellular
Fluorescence detection of protoporphyrin IX in living cells: a comparative study on single- and two-photon excitation.
Carcinoma, Hepatocellular
Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.
Carcinoma, Hepatocellular
Identification of Cancer Stem Cell Subpopulations of CD34(+) PLC/PRF/5 That Result in Three Types of Human Liver Carcinomas.
Carcinoma, Hepatocellular
In situ expression patterns of melanoma inhibitory activity 2 in healthy and diseased livers.
Carcinoma, Hepatocellular
In vitro stimulation of cell growth by hepatic stimulator substance.
Carcinoma, Hepatocellular
Increased activity and nuclear localisation of inositol lipid signal transduction enzymes in rat hepatoma cells.
Carcinoma, Hepatocellular
Increased porphyrins in primary liver cancer mainly reflect a parallel liver disease.
Carcinoma, Hepatocellular
Increased signal transduction activity and down-regulation in human cancer cells.
Carcinoma, Hepatocellular
Inositol-specific phospholipase C in low and fast proliferating hepatoma cell lines.
Carcinoma, Hepatocellular
Intracellular distribution of phospholipase C gamma 1 in cell lines with different levels of transformation.
Carcinoma, Hepatocellular
Intracellular trafficking and cellular uptake mechanism of mPEG-PLGA-PLL and mPEG-PLGA-PLL-Gal nanoparticles for targeted delivery to hepatomas.
Carcinoma, Hepatocellular
Low PLCE1 levels are correlated with poor prognosis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
M-3M3FBS-Induced Ca² ? Movement and Apoptosis in HA59T Human Hepatoma Cells.
Carcinoma, Hepatocellular
Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma.
Carcinoma, Hepatocellular
microRNA-29a suppresses cell proliferation by targeting SPARC in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Noninvasive discrimination of human normal cells and malignant tumor cells by phase-shifting laser microscopy.
Carcinoma, Hepatocellular
Oncogenic role of phospholipase C-?1 in progression of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Perceived dietary salt intake and the risk of primary liver cancer: a population-based prospective study.
Carcinoma, Hepatocellular
Phospholipase C (EC 3.1.4.11): a malignancy linked signal transduction enzyme.
Carcinoma, Hepatocellular
Practice guidelines for the pathological diagnosis of primary liver cancer: 2015 update.
Carcinoma, Hepatocellular
Primitive liver cancers: epidemiology and geographical study in France.
Carcinoma, Hepatocellular
Prognostic value of LI-RADS category on gadoxetic acid-enhanced MRI and 18F-FDG PET-CT in patients with primary liver carcinomas.
Carcinoma, Hepatocellular
Prognostic value of LINE-1 methylation level in 321 patients with primary liver cancer including hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
Carcinoma, Hepatocellular
Purification and characterization of a major glycoprotein in rat hepatoma plasma membranes. One of the membrane proteins released by phosphatidylinositol-specific phospholipase C.
Carcinoma, Hepatocellular
Remodelling and Improvements in Organoid Technology to Study Liver Carcinogenesis in a Dish.
Carcinoma, Hepatocellular
Sorting of synaptophysin into special vesicles in nonneuroendocrine epithelial cells.
Carcinoma, Hepatocellular
Studies on a novel cytocidal antibiotic, trienomycin A. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics.
Carcinoma, Hepatocellular
Talin-1 correlates with reduced invasion and migration in human hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
TGF-?1 Induces Immune Escape by Enhancing PD-1 and CTLA-4 Expression on T Lymphocytes in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
The alteration of cytokeratin 18 molecule and its mRNA expression during tumor transformation in hepatoma.
Carcinoma, Hepatocellular
The chemical carcinogen-induced enzyme, GDP-fucose: GM1 alpha 1----2 fucosyltransferase in rat liver and hepatoma: modulation by and association with phospholipids.
Carcinoma, Hepatocellular
The riminophenazine agents clofazimine and B669 inhibit the proliferation of intrinsically multidrug resistant carcinoma cell lines.
Carcinoma, Hepatocellular
Up-regulated expression of phospholipase C, ?1 is associated with tumor cell proliferation and poor prognosis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Whole-exome mutational and transcriptional landscapes of combined hepatocellular cholangiocarcinoma and intrahepatic cholangiocarcinoma reveal molecular diversity.
Carcinoma, Hepatocellular
[Antitumor effect of adriamycin entrapped in liposomes conjugated with anti-human alpha-fetoprotein or anti-carcinoembryonic antigen monoclonal antibodies]
Carcinoma, Hepatocellular
[Current estimate of the number of patients for liver transplantation with Dutch mortality figures]
Carcinoma, Hepatocellular
[Differential expressions analysis of piwi-interacting RNAs in hepatocellular carcinoma].
Carcinoma, Hepatocellular
[Establishment and gene expression analysis of drug-resistant cell lines in hepatocellular carcinoma induced by sorafenib].
Carcinoma, Hepatocellular
[Investigation of the lipid dependence of pyrophosphatase activity from rat liver microsomes and hepatoma by phospholipase C]
Carcinoma, Hepatocellular
[Molecular markers and mechanisms for stemness maintenance of liver cancer stem cells: a review].
Carcinoma, Intraductal, Noninfiltrating
Apocrine differentiation in invasive pleomorphic lobular carcinoma with in situ ductal and lobular apocrine carcinoma: case report.
Carcinoma, Lobular
Clinicopathological characteristics and survival outcomes in pleomorphic lobular breast carcinoma of the breast: a SEER population-based study.
Carcinoma, Lobular
Fine needle aspiration cytology of pleomorphic lobular carcinoma of the breast. Duct carcinoma as a diagnostic pitfall.
Carcinoma, Lobular
Pleomorphic lobular carcinoma of the breast: a comparison of cytopathological features with other lobular carcinoma variants.
Carcinoma, Non-Small-Cell Lung
Clinical relevance of intraoperative pleural lavage cytology in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Clinical significance of pleural lavage cytology for non-small cell lung cancer: is surgical resection valid for patients with positive pleural lavage cytology?
Carcinoma, Non-Small-Cell Lung
Distinct Prognostic Values of Phospholipase C Beta Family Members for Non-Small Cell Lung Carcinoma.
Carcinoma, Non-Small-Cell Lung
Novel water-soluble derivatives of docosahexaenoic acid increase diacylglycerol production mediated by phosphatidylcholine-specific phospholipase C.
Carcinoma, Ovarian Epithelial
Gonadotropin-releasing hormone stimulates phospholipase C but not protein phosphorylation/dephosphorylation in plasma membrane from human epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Phosphatidylcholine-specific phospholipase C activation in epithelial ovarian cancer cells.
Carcinoma, Renal Cell
Activation of phospholipase C induces the expression of the multidrug resistance (MDR1) gene through the Raf-MAPK pathway.
Carcinoma, Renal Cell
Phase II study of troxacitabine (BCH-4556) in patients with advanced and/or metastatic renal cell carcinoma: a trial of the National Cancer Institute of Canada-Clinical Trials Group.
Carcinoma, Signet Ring Cell
A Rare Case of Progressive Dyspnea and Bilateral Lung Infiltration in a Young Male.
Carcinoma, Squamous Cell
Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A-431 cells.
Carcinoma, Squamous Cell
Epidermal growth factor regulates topoisomerase II activity and drug sensitivity in human KB cells.
Carcinoma, Squamous Cell
Extracellular HspBP1 and Hsp72 synergistically activate epidermal growth factor receptor.
Carcinoma, Squamous Cell
Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells.
Carcinoma, Squamous Cell
Hyaluronan-CD44 promotes phospholipase C-mediated Ca2+ signaling and cisplatin resistance in head and neck cancer.
Carcinoma, Squamous Cell
Inhibition of Phosphatidylcholine-Specific Phospholipase C Interferes with Proliferation and Survival of Tumor Initiating Cells in Squamous Cell Carcinoma.
Carcinoma, Squamous Cell
Novel genetic variants in genes of the Fc gamma receptor-mediated phagocytosis pathway predict non-small cell lung cancer survival.
Carcinoma, Squamous Cell
Pemphigus IgG induces expression of urokinase plasminogen activator receptor on the cell surface of cultured keratinocytes.
Carcinoma, Squamous Cell
Pharmacologic evidence for involvement of phospholipase C in pemphigus IgG-induced inositol 1,4,5-trisphosphate generation, intracellular calcium increase, and plasminogen activator secretion in DJM-1 cells, a squamous cell carcinoma line.
Carcinoma, Squamous Cell
Prognostic value of intraoperative pleural lavage cytology for lung cancer without carcinomatous pleuritis: importance in patients with early stage disease during long-term follow-up.
Carcinoma, Squamous Cell
Pulmonary lymphangitic carcinomatosis from head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
The epidermal growth factor receptor is coupled to a pertussis toxin-sensitive guanine nucleotide regulatory protein in rat hepatocytes.
Carcinoma, Squamous Cell
The influence of hyaluronan-CD44 interaction on topoisomerase II activity and etoposide cytotoxicity in head and neck cancer.
Carcinoma, Squamous Cell
The release of Hsp70 from A431 carcinoma cells is mediated by secretory-like granules.
Cardiac Tamponade
Syncope and Cardiac Tamponade: Multimodality Imaging of Primary Cardiac Lymphoma.
Cardiomegaly
Alterations of phosphoinositide-specific phospholipase C and protein kinase C in the myocardium of spontaneously hypertensive rats.
Cardiomegaly
Angiotensin II induced upregulation of G alpha q/11, phospholipase C beta 3 and extracellular signal-regulated kinase 1/2 via angiotensin II type 1 receptor.
Cardiomegaly
Differential regulation of phospholipase C-beta isozymes in cardiomyocyte hypertrophy.
Cardiomegaly
Dilated cardiomyopathy in two transgenic mouse lines expressing activated G protein alpha(q): lack of correlation between phospholipase C activation and the phenotype.
Cardiomegaly
G protein ?? subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway.
Cardiomegaly
Hemodynamic and metabolic activities of propionyl-L-carnitine in rats with pressure-overload cardiac hypertrophy.
Cardiomegaly
Losartan attenuates phospholipase C isozyme gene expression in hypertrophied hearts due to volume overload.
Cardiomegaly
Mechanical stress stimulates phospholipase C activity and intracellular calcium ion levels in neonatal rat cardiomyocytes.
Cardiomegaly
Norepinephrine-induced changes in gene expression of phospholipase C in cardiomyocytes.
Cardiomegaly
Phospholipase C gene expression, protein content, and activities in cardiac hypertrophy and heart failure due to volume overload.
Cardiomegaly
Phospholipase C may be involved in norepinephrine-induced cardiac hypertrophy.
Cardiomegaly
Signal transduction during cardiac hypertrophy: the role of G alpha q, PLC beta I, and PKC.
Cardiomyopathies
Carnitine deficiency aggravates cyclophosphamide-induced cardiotoxicity in rats.
Cardiomyopathies
Propionyl-L-carnitine as protector against adriamycin-induced cardiomyopathy.
Cardiomyopathies
Propionyl-l-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model.
Cardiomyopathy, Dilated
A transgenic mouse model of heart failure using inducible Galpha q.
Cardiomyopathy, Dilated
Dilated cardiomyopathy in two transgenic mouse lines expressing activated G protein alpha(q): lack of correlation between phospholipase C activation and the phenotype.
Cardiomyopathy, Dilated
Positive inotropic effect of coenzyme Q10, omega-3 fatty acids and propionyl-L-carnitine on papillary muscle force-frequency responses of BIO TO-2 cardiomyopathic Syrian hamsters.
Cardiomyopathy, Dilated
Selective activation of the "b" splice variant of phospholipase Cbeta1 in chronically dilated human and mouse atria.
Cardiotoxicity
Carnitine deficiency aggravates cyclophosphamide-induced cardiotoxicity in rats.
Cardiotoxicity
Carnitine deficiency and oxidative stress provoke cardiotoxicity in an ifosfamide-induced Fanconi syndrome rat model:
Cardiotoxicity
Changes in the levels of l-carnitine, acetyl-l-carnitine and propionyl-l-carnitine are involved in perfluorooctanoic acid induced developmental cardiotoxicity in chicken embryo.
Cardiotoxicity
Demonstration of the cardiotoxicity of the thermostable direct hemolysin (lethal toxin) produced by Vibrio parahaemolyticus.
Cardiotoxicity
Dissecting Cellular Mechanisms of Long-Chain Acylcarnitines-Driven Cardiotoxicity: Disturbance of Calcium Homeostasis, Activation of Ca2+-Dependent Phospholipases, and Mitochondrial Energetics Collapse.
Cardiotoxicity
Isolation of mutant toxins of Vibrio parahaemolyticus hemolysin by in vitro mutagenesis.
Cardiotoxicity
Properties of a hemolysin related to the thermostable direct hemolysin produced by a Kanagawa phenomenon negative, clinical isolate of Vibrio parahaemolyticus.
Cardiotoxicity
Propionyl-L-carnitine as potential protective agent against adriamycin-induced impairment of fatty acid beta-oxidation in isolated heart mitochondria.
Cardiotoxicity
Propionyl-l-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model.
Cardiotoxicity
Vibrio parahaemolyticus, enterotoxigenic Escherichia coli, enterohemorrhagic Escherichia coli and Vibrio cholerae.
Cardiovascular Diseases
Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders.
Cardiovascular Diseases
Pharmacological effects and clinical applications of propionyl-L-carnitine.
Cardiovascular Diseases
Phospholipase C mediated inhibition of factor VII requires triglyceride-rich lipoproteins.
Cardiovascular Diseases
The flavonoids quercetin and catechin synergistically inhibit platelet function by antagonizing the intracellular production of hydrogen peroxide.
Catalepsy
Dopaminergic behaviors and signal transduction mediated through adenylate cyclase and phospholipase C pathways.
Celiac Disease
GSK-1605786, a selective small-molecule antagonist of the CCR9 chemokine receptor for the treatment of Crohn's disease.
Cerebellar Diseases
Curcumin modulates dopaminergic receptor, CREB and phospholipase C gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats.
Chagas Disease
Placental alkaline phosphatase (PLAP) enzyme activity and binding to IgG in Chagas' disease.
Chancroid
Prevalence of, antibody response to, and immunity induced by Haemophilus ducreyi hemolysin.
Chancroid
Target cell range of Haemophilus ducreyi hemolysin and its involvement in invasion of human epithelial cells.
Cholangiocarcinoma
A comparison of trends in mortality from primary liver cancer and intrahepatic cholangiocarcinoma in Europe.
Cholangiocarcinoma
Abdominal and gluteofemoral size and risk of liver cancer: The liver cancer pooling project.
Cholangiocarcinoma
Alpha(1)-and beta(2)-adrenoceptors in the human liver with mass-forming intrahepatic cholangiocarcinoma: density and coupling to adenylate cyclase and phospholipase C.
Cholangiocarcinoma
Central liver toxicity after SBRT: An expanded analysis and predictive nomogram.
Cholangiocarcinoma
Contribution of Hepatitis B, C Virus to Liver Cancer in China North Areas: Experience from Chinese National Cancer Center.
Cholangiocarcinoma
Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.
Cholangiocarcinoma
Identification of Cancer Stem Cell Subpopulations of CD34(+) PLC/PRF/5 That Result in Three Types of Human Liver Carcinomas.
Cholangiocarcinoma
Immunohistochemical characterization of 130 cases of primary hepatic carcinomas.
Cholangiocarcinoma
Incidence of primary liver cancer and aetiological aspects: a study of a defined population from a low-endemicity area.
Cholangiocarcinoma
Increased porphyrins in primary liver cancer mainly reflect a parallel liver disease.
Cholangiocarcinoma
Perceived dietary salt intake and the risk of primary liver cancer: a population-based prospective study.
Cholangiocarcinoma
Primary liver cancer in the UK: Incidence, incidence-based mortality, and survival by subtype, sex, and nation.
Cholangiocarcinoma
Prognostic value of LI-RADS category on gadoxetic acid-enhanced MRI and 18F-FDG PET-CT in patients with primary liver carcinomas.
Cholangiocarcinoma
Prognostic value of LINE-1 methylation level in 321 patients with primary liver cancer including hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
Cholangiocarcinoma
Remodelling and Improvements in Organoid Technology to Study Liver Carcinogenesis in a Dish.
Cholangiocarcinoma
Whole-exome mutational and transcriptional landscapes of combined hepatocellular cholangiocarcinoma and intrahepatic cholangiocarcinoma reveal molecular diversity.
Cholangiocarcinoma
[Molecular markers and mechanisms for stemness maintenance of liver cancer stem cells: a review].
Cholecystitis, Acute
Evaluation of the Safety and Efficacy of Percutaneous Transhepatic Gallbladder Drainage Combined with Laparoscopic Cholecystectomy for Treating Acute Complicated Cholecystitis.
Cholecystitis, Acute
Is postponed laparoscopic cholecystectomy justified for acute cholecystitis appearing early after onset?
Cholera
A comparative study of endothelin- and platelet-activating-factor-mediated signal transduction and prostaglandin synthesis in rat Kupffer cells.
Cholera
Acetylcholine and cholecystokinin receptors functionally couple by different G-proteins to phospholipase C in pancreatic acinar cells.
Cholera
Activation of corticotropin-releasing factor receptor 1 selectively inhibits CaV3.2 T-type calcium channels.
Cholera
Activation of phospholipase C via adenosine receptors provides synergistic signals for secretion in antigen-stimulated RBL-2H3 cells. Evidence for a novel adenosine receptor.
Cholera
Alterations in Vibrio cholerae motility phenotypes correlate with changes in virulence factor expression.
Cholera
Analysis of the Vibrio pathogenicity island-encoded Mop protein suggests a pleiotropic role in the virulence of epidemic Vibrio cholerae.
Cholera
Angiotensin II stimulation of vascular smooth muscle cells. Secondary signalling mechanisms.
Cholera
Beta-adrenergic receptor-mediated phospholipase C activation independent of cAMP formation in turkey erythrocyte membranes.
Cholera
Calcium signaling through phospholipase C activates dendritic cells to mature and is necessary for the activation and maturation of dendritic cells induced by diverse agonists.
Cholera
Cellular mechanisms of cholera toxin-mediated modulation of in vitro hemolysin formation by mouse immunocytes.
Cholera
Characterization of phenotypic, serological, and toxigenic traits of Vibrio cholerae O139 bengal.
Cholera
Cholera toxin modulation of angiotensin II-stimulated inositol phosphate production in cultured vascular smooth muscle cells.
Cholera
Cholinergic-induced [3H] noradrenaline release in rat brain cortical slices is mediated via a pertussis toxin sensitive GTP binding protein and involves activation of protein kinase C.
Cholera
Collagen type IV stimulates an increase in intracellular Ca2+ in pancreatic acinar cells via activation of phospholipase C.
Cholera
Construction of a recombinant live oral vaccine from a non-toxigenic strain of Vibrio cholerae O1 serotype inaba biotype E1 Tor and assessment of its reactogenicity and immunogenicity in the rabbit model.
Cholera
Detection of Vibrio cholerae by real-time nucleic acid sequence-based amplification.
Cholera
Determinants of immunogenicity and mechanisms of protection by virulent and mutant Vibrio cholerae O1 in rabbits.
Cholera
Different endothelin receptor subtypes are involved in phospholipid signalling in the proximal tubule of rat kidney.
Cholera
Distribution of genes encoding cholera toxin, zonula occludens toxin, accessory cholera toxin, and El Tor hemolysin in Vibrio cholerae of diverse origins.
Cholera
Dopamine acutely decreases type 3 Na(+)/H(+) exchanger activity in renal OK cells through the activation of protein kinases A and C signalling cascades.
Cholera
Effect of nonhydrolyzable guanosine phosphate on IgE-mediated activation of phospholipase C and histamine release from rodent mast cells.
Cholera
Effects of antibody to Vibrio cholerae El Tor hemolysin on pathological changes of the intestines in cholera.
Cholera
Effects of insulin, pertussis toxin and cholera toxin on protein synthesis and diacylglycerol production in 3T3 fibroblasts: evidence for a G-protein mediated activation of phospholipase C in the insulin signal mechanism.
Cholera
El Tor Biotype Vibrio cholerae Activates the Caspase-11-Independent Canonical Nlrp3 and Pyrin Inflammasomes.
Cholera
Expression of Hemolysin Is Regulated Under the Collective Actions of HapR, Fur, and HlyU in Vibrio cholerae El Tor Serogroup O1.
Cholera
Failure of antisera to thermostable direct hemolysin and cholera enterotoxin to prevent accumulation of fluid caused by Vibrio parahaemolyticus.
Cholera
Foodborne disease outbreaks caused by sucrose-nonfermenting and beta-galactosidase-deficient variants of Vibrio cholerae.
Cholera
Genetic analysis of the chromosomal region encoding lysophospholipase L2 of Vibrio cholerae O1.
Cholera
Histamine H2 receptor activates adenylate cyclase and PLC via separate GTP-dependent pathways.
Cholera
Light-dependent translocation of arrestin in rod photoreceptors is signaled through a phospholipase C cascade and requires ATP.
Cholera
Lysophosphatidic acid augments fibroblast-mediated contraction of released collagen gels.
Cholera
Mechanisms of inflammasome activation by Vibrio cholerae secreted toxins vary with strain biotype.
Cholera
Molecular analysis of Vibrio cholerae O1, O139, non-O1, and non-O139 strains: clonal relationships between clinical and environmental isolates.
Cholera
Multiple signaling pathways of histamine H2 receptors. Identification of an H2 receptor-dependent Ca2+ mobilization pathway in human HL-60 promyelocytic leukemia cells.
Cholera
Mutations in the extracellular protein secretion pathway genes (eps) interfere with rugose polysaccharide production in and motility of Vibrio cholerae.
Cholera
Na+ regulation of formyl peptide receptor-mediated signal transduction in HL 60 cells. Evidence that the cation prevents activation of the G-protein by unoccupied receptors.
Cholera
Necrotizing fasciitis due to Vibrio cholerae non-O1/non-O139 after exposure to Austrian bathing sites.
Cholera
On the mechanism of action of dexamethasone in a rat mast cell line (RBL-2H3 cells). Evidence for altered coupling of receptors and G-proteins.
Cholera
Phenotypic Analysis Reveals that the 2010 Haiti Cholera Epidemic Is Linked to a Hypervirulent Strain.
Cholera
Phenotypic and genotypic characterization Vibrio cholerae O139 of clinical and aquatic isolates in China.
Cholera
Photoaffinity labeling with GTP-gamma-azidoanilide of a cholera toxin-sensitive 40 kDa protein from pancreatic acinar cells.
Cholera
Plasma and Mucosal Immunoglobulin M, Immunoglobulin A, and Immunoglobulin G Responses to the Vibrio cholerae O1 Protein Immunome in Adults With Cholera in Bangladesh.
Cholera
Prolonged colonization of mice by Vibrio cholerae El Tor O1 depends on accessory toxins.
Cholera
Properties of membranous phospholipase C from WRK1 cell: sensitivity to guanylnucleotides and bacterial toxins.
Cholera
Purification and characterization of a hemolysin produced by Vibrio cholerae biotype El Tor: another toxic substance produced by cholera vibrios.
Cholera
Purification and characterization of an extracellular secretogenic non-membrane-damaging cytotoxin produced by clinical strains of Vibrio cholerae non-O1.
Cholera
Quadruplex Real-Time PCR Assay for Detection and Identification of Vibrio cholerae O1, O139, and Their Toxigenic Potential.
Cholera
Rapid membrane responses to dihydrotestosterone are sex dependent in growth plate chondrocytes.
Cholera
Risk of Vibrio transmission linked to the consumption of crustaceans in coastal towns of Côte d'Ivoire.
Cholera
Safety and immunogenicity of single-dose live oral cholera vaccine strain CVD 103-HgR, prepared from new master and working cell banks.
Cholera
Signal transduction via the B cell antigen receptor: involvement of a G protein and regulation of signaling.
Cholera
Thapsigargin-induced secretion is dependent on activation of a cholera toxin-sensitive and phosphatidylinositol-3-kinase-regulated phospholipase D in a mast cell line.
Cholera
The G protein coupling T cell antigen receptor/CD3-complex and phospholipase C in the human T cell lymphoma Jurkat is not a target for cholera toxin.
Cholera
The role of bacterial and non-bacterial toxins in the induction of changes in membrane transport: implications for diarrhea.
Cholera
Trypanosoma cruzi: infection of cultured human endothelial cells alters inositol phosphate synthesis.
Cholera
Vibrio parahaemolyticus, enterotoxigenic Escherichia coli, enterohemorrhagic Escherichia coli and Vibrio cholerae.
Cholera
Virulence profile and clonal relationship among the Vibrio cholerae isolates from ground and surface water in a cholera endemic area during rainy season.
Cholera
[Antibacterial and anti-hemolysin activities of tea catechins and their structural relatives]
Cholera
[Cholera vibrios lectins as main pathogenicity and persistence factors (biotechnological aspects of use)].
Cholera
[Genetic determination and the spectrum of the hemolytic activity of Vibrio cholerae: their significance in the complex of biovar-specific traits]
Cholera
[Immunochemical and biochemical characteristics of a preventive preparation against cholera, cholerogen-toxoid]
Cholera
[Relationship between the anti-hemolysin activity and the structure of catechins and theaflavins]
Cholera
[Role of galactose-specific receptor--lectin in bactericidal activity of hemolysin of Vibrio cholerae non O1/O139]
Cholera
[Sporadic diarrhea caused by Vibrio cholerae non-O1 and characteristics of the isolates]
Cholera
[Studies on the enteropathogenic mechanism of non-O1 Vibrio cholerae. III. Production of enteroreactive toxins]
Cholera
[The expression of the pathogenic properties of the Vibrio cholerae O139 serogroup in vitro]
Choriocarcinoma
Colocalization of acidic and basic fibroblast growth factor (FGF) in human placenta and the cellular effects of bFGF in trophoblast cell line JEG-3.
Choroidal Neovascularization
Role of c-Cbl Dependent Regulation of Phospholipase C gamma 1 Activation in Experimental Choroidal Neovascularization.
Choroidal Neovascularization
Statistical driver genes as a means to uncover missing heritability for age-related macular degeneration.
Chronic Periodontitis
Genetic and phenotypic evaluation of Candida albicans strains isolated from subgingival biofilm of diabetic patients with chronic periodontitis.
Chronic Periodontitis
Modulation of host matrix metalloproteinases by bacterial virulence factors relevant in human periodontal diseases.
Coinfection
Loss of hemolysin expression in Staphylococcus aureus agr mutants correlates with selective survival during mixed infections in murine abscesses and wounds.
Coinfection
Phospholipase gene expression during Paracoccidioides brasiliensis morphological transition and infection.
Coinfection
Serum antibody response to Pseudomonas aeruginosa antigens during corneal infection.
Coinfection
The luteinizing hormone receptor activates phospholipase C via preferential coupling to Gi2.
Coinfection
[Primary carcinoma of the liver and hepatitis C virus in Italy. A prospective study in patients with cirrhosis]
Colitis
Chronic Psychological Stress Disrupted the Composition of the Murine Colonic Microbiota and Accelerated a Murine Model of Inflammatory Bowel Disease.
Colitis
EXPRESS: Phospholipase C gamma mediates endogenous brain-derived neurotrophic factor - regulated calcitonin gene-related peptide expression in colitis - induced visceral pain.
Colitis
Propionyl-L-Carnitine is Efficacious in Ulcerative Colitis Through its Action on the Immune Function and Microvasculature.
Colitis, Collagenous
Paucicellular lymphocytic colitis: is it a minor form of lymphocytic colitis? A clinical pathological and immunological study.
Colitis, Lymphocytic
Paucicellular lymphocytic colitis: is it a minor form of lymphocytic colitis? A clinical pathological and immunological study.
Colitis, Microscopic
Paucicellular lymphocytic colitis: is it a minor form of lymphocytic colitis? A clinical pathological and immunological study.
Colitis, Ulcerative
Plasma pharmacokinetics and gastrointestinal transit of a new Propionyl-l-Carnitine controlled release formulation.
Colonic Neoplasms
A hallmark of immunoreceptor, the tyrosine-based inhibitory motif ITIM, is present in the G protein-coupled receptor OX1R for orexins and drives apoptosis: a novel mechanism.
Colonic Neoplasms
Changes in serum levels of Forssman-like antibody in patients with gastric cancer.
Colonic Neoplasms
Designing a light-activated recombinant alpha hemolysin for colorectal cancer targeting.
Colonic Neoplasms
Growth inhibition, enhancement of intercellular adhesion, and increased expression of carcinoembryonic antigen by overexpression of phosphoinositides-specific phospholipase C beta 1 in LS174T human colon adenocarcinoma cell line.
Colonic Neoplasms
Integrative approach for prioritizing cancer genes in sporadic colon cancer.
Colonic Neoplasms
Phospholipase C ?1 negatively regulates autophagy in colorectal cancer cells.
Colonic Neoplasms
Reduced expression of phospholipase C-delta, a signal-transducing enzyme, in rat colon neoplasms induced by methylazoxymethanol acetate.
Colonic Neoplasms
The effect of unsaturated fatty acids on membrane composition and signal transduction in HT-29 human colon cancer cells.
Colonic Neoplasms
Thermostable direct hemolysin downregulates human colon carcinoma cell proliferation with the involvement of E-cadherin, and ?-catenin/Tcf-4 signaling.
Colonic Neoplasms
[Antitumor effect of adriamycin entrapped in liposomes conjugated with anti-human alpha-fetoprotein or anti-carcinoembryonic antigen monoclonal antibodies]
Colorectal Neoplasms
Antitumour effects on human colorectal carcinomas cells by stable silencing of phospholipase C-gamma 1 with lentivirus-delivered siRNA.
Colorectal Neoplasms
Biological significance of genome-wide DNA methylation profiles in keloids.
Colorectal Neoplasms
Designing a light-activated recombinant alpha hemolysin for colorectal cancer targeting.
Colorectal Neoplasms
Elevated content of phospholipase C-gamma 1 in colorectal cancer tissues.
Colorectal Neoplasms
Enhanced phosphoinositide metabolism in colorectal carcinoma cells derived from familial adenomatous polyposis patients.
Colorectal Neoplasms
Growth inhibition by phospholipase C inhibitor peptides of colorectal carcinoma cells derived from familial adenomatous polyposis.
Colorectal Neoplasms
Phospholipase C ?1 negatively regulates autophagy in colorectal cancer cells.
Colorectal Neoplasms
Phospholipase C?1 represses colorectal cancer growth by inhibiting the Wnt/?-catenin signaling axis.
Colorectal Neoplasms
Platelet count and survival in patients with colorectal cancer--a preliminary study.
Colorectal Neoplasms
The phosphoinositide hydrolase phospholipase C delta1 inhibits epithelial-mesenchymal transition and is silenced in colorectal cancer.
Colorectal Neoplasms
The riminophenazine agents clofazimine and B669 inhibit the proliferation of intrinsically multidrug resistant carcinoma cell lines.
Colorectal Neoplasms
[Construction of lentivirus producing PLC-gamma1 siRNA and its effect on apoptosis of human colorectal carcinomas cell lines]
Colorectal Neoplasms
[Inhibition of phospholipase C gamma1 signaling pathway promotes apoptosis of human colorectal carcinoma cells]
Coma
Cloning, expression, and nucleotide sequence of genes involved in production of pediocin PA-1, and bacteriocin from Pediococcus acidilactici PAC1.0.
Coma
Genetic transformation in Streptococcus pneumoniae: nucleotide sequence analysis shows comA, a gene required for competence induction, to be a member of the bacterial ATP-dependent transport protein family.
Common Variable Immunodeficiency
A Germline Mutation in the C2 Domain of PLC?2 Associated with Gain-of-Function Expands the Phenotype for PLCG2-Related Diseases.
Confusion
MRI of the posterolateral corner of the knee: normal appearance and patterns of injury.
Congenital Abnormalities
Assessment of Interobserver Variability for CT Scan-Based Evaluation of Posterior Ligament Complex Injury in Thoracolumbar Fractures: An International Multicenter Pilot Study.
Congenital Abnormalities
Posterolateral Corner Reconstruction using the Anatomical Two-Tailed Graft Technique: Clinical Outcomes in the Multiligament Injured Knee.
Congenital Abnormalities
Semitendinosus Tendon Augmentation for Prevention of Proximal Junctional Failure.
Contracture
Changes in contractility and calcium binding of guinea pig taenia coli by treatment with enzymes which hydrolyze sialic acid.
Contracture
Comparison of the effects of mefloquine and ryanodine on the directly stimulated rat hemidiaphragm preparation.
Contracture
Dependence of cyclopiazonic-acid-induced muscle contractures on extracellular Ca2+.
Contracture
Effect of hemolysin produced by Vibrio parahaemolyticus on membrane conductance and mechanical tension of rabbit myocardium.
Contracture
Possible mechanisms of action of cobra snake venom cardiotoxins and bee venom melittin.
Contracture
The effect of hydrolytic enzymes on the acetylcholine sensitivity of the skeletal muscle cell membrane.
Coronary Artery Disease
Changes in skeletal muscle histology and metabolism in patients undergoing exercise deconditioning: effect of propionyl-L-carnitine.
Coronary Artery Disease
[Acute effects of propionyl-L-carnitine on anomalies of parietal kinetics of the left ventricle induced by atrial pacing in patients with ischemic heart disease. A bidimensional echocardiographic study]
Cough
Occult pulmonary lymphangitic carcinomatosis presenting as 'chronic cough' with a normal HRCT chest.
Cough
Pulmonary lymphangitic carcinomatosis from an oropharyngeal squamous cell carcinoma: a case report.
Cough
Pulmonary lymphangitis carcinomatosis: systematic review and meta-analysis of case reports, 1970-2018.
COVID-19
Association between peripheral lymphocyte count and the mortality risk of COVID-19 inpatients.
Crohn Disease
GSK-1605786, a selective small-molecule antagonist of the CCR9 chemokine receptor for the treatment of Crohn's disease.
Cystic Fibrosis
Alpha 1-adrenergic signaling in human airway epithelial cells involves inositol lipid and phosphate metabolism.
Cystic Fibrosis
Fluid secretion caused by aerolysin-like hemolysin of Aeromonas sobria in the intestines is due to stimulation of production of prostaglandin E2 via cyclooxygenase 2 by intestinal cells.
Cystic Fibrosis
Functional replacement of the hemolysin A transport signal by a different primary sequence.
Cystic Fibrosis
Immunohistochemical localization of cystic fibrosis transmembrane regulator and clara cell secretory protein in taste receptor cells of rat circumvallate papillae.
Cystic Fibrosis
Increased phosphoinositide breakdown by phospholipase C in erythrocyte membranes from patients with cystic fibrosis.
Cystic Fibrosis
Molecular typing and biological characteristics of Pseudomonas aeruginosa isolated from cystic fibrosis patients in Brazil.
Cystic Fibrosis
Prospective study of serum antibodies to Pseudomonas aeruginosa exoproteins in cystic fibrosis.
Cystic Fibrosis
Pseudomonas aeruginosa and cystic fibrosis: correlation between exoenzyme production and patient's clinical state.
Cystic Fibrosis
Pseudomonas aeruginosa from patients with cystic fibrosis affects function of pulmonary surfactant.
Cystic Fibrosis
Relation between antibody response to Pseudomonas aeruginosa exoproteins and colonization/infection in patients with cystic fibrosis.
Cystic Fibrosis
Repurposing calcium-sensing receptor agonist cinacalcet for treatment of CFTR-mediated secretory diarrheas.
Cystic Fibrosis
[Serodiagnosis of Pseudomonas aeruginosa infections in mucoviscidosis: comparative study of Western blotting, ELISA exotoxin A and ELISA phospholipase C]
Cystitis
?-Hemolysin of uropathogenic E. coli regulates NLRP3 inflammasome activation and mitochondrial dysfunction in THP-1 macrophages.
Cystitis
Characteristics of Escherichia coli in acute community-acquired cystitis of adult women.
Cystitis
Cytotoxicity of hemolytic, cytotoxic necrotizing factor 1-positive and -negative Escherichia coli to human T24 bladder cells.
Cystitis
Differences in virulence factors among clinical isolates of Escherichia coli causing cystitis and pyelonephritis in women and prostatitis in men.
Cystitis
Distribution of virulence factors in Escherichia coli isolated from urine of cystitis patients.
Cystitis
Expression and detection of pap-, sfa-, and afa-encoded fimbrial adhesin systems among uropathogenic Escherichia coli.
Cystitis
Hemagglutination of human type O erythrocytes, hemolysin production, and serogrouping of Escherichia coli isolates from patients with acute pyelonephritis, cystitis, and asymptomatic bacteriuria.
Cystitis
papG alleles of Escherichia coli strains causing first-episode or recurrent acute cystitis in adult women.
Cystitis
Urovirulence determinants in Escherichia coli isolates causing first-episode and recurrent cystitis in women.
Cystitis
Virulence characteristics of Escherichia coli in relation to host response in men with symptomatic urinary tract infection.
Cysts
A Monoallelic Two-Hit Mechanism in PLCD1 Explains the Genetic Pathogenesis of Hereditary Trichilemmal Cyst Formation.
Cysts
Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells.
Cysts
Hereditary Trichilemmal Cysts are Caused by Two Hits to the Same Copy of the Phospholipase C Delta 1 Gene (PLCD1).
Cysts
Identification and partial purification of phosphatidylcholine phospholipase C from the cryptobiotic cysts of the fairy shrimp, Streptocephalus dichotomus.
Cysts
Toxoplasma gondii: role of the phosphatidylcholine-specific phospholipase C during cell invasion and intracellular development.
Dehydration
Analysis of spatial and temporal dynamics of xylem refilling in Acer rubrum L. using magnetic resonance imaging.
Dehydration
Effects of summer drought and winter freezing on stem hydraulic conductivity of Rhododendron species from contrasting climates.
Dehydration
Genome wide characterization of phospholipase A & C families and pattern of lysolipids and diacylglycerol changes under abiotic stresses in Brassica napus L.
Dehydration
Patterns of PIP gene expression in Populus trichocarpa during recovery from xylem embolism suggest a major role for the PIP1 aquaporin subfamily as moderators of refilling process.
Dehydration
Relationships between stomatal behavior, xylem vulnerability to cavitation and leaf water relations in two cultivars of Vitis vinifera
Dehydration
Relationships between stomatal behavior, xylem vulnerability to cavitation and leaf water relations in two cultivars of Vitis vinifera.
Dehydration
The dynamics of carbon stored in xylem sapwood to drought-induced hydraulic stress in mature trees.
Dementia
A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.
Dementia
Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.
Dengue
Host factor prioritization for pan-viral genetic perturbation screens using random intercept models and network propagation.
Dengue
Joint ancestry and association test indicate two distinct pathogenic pathways involved in classical dengue fever and dengue shock syndrome.
Dental Plaque
Modulation of host matrix metalloproteinases by bacterial virulence factors relevant in human periodontal diseases.
Dermatitis
Comparative clinicopathological study on pityriasis lichenoides chronica and small plaque parapsoriasis.
Dermatitis, Atopic
A controlled trial of traditional Chinese herbal medicine in Chinese patients with recalcitrant atopic dermatitis.
Dermatitis, Atopic
Genomic analysis of variability in Delta-toxin levels between Staphylococcus aureus strains.
Dermatitis, Atopic
Intracellular 3',5'-adenosine cyclic monophosphate level regulates house dust mite-induced interleukin-13 production by T cells from mite-sensitive patients with atopic dermatitis.
Diabetes Mellitus
Albiglutide, an albumin-based fusion of glucagon-like peptide 1 for the potential treatment of type 2 diabetes.
Diabetes Mellitus
Dapagliflozin, an oral sodium glucose cotransporter type 2 inhibitor for the treatment of type 2 diabetes mellitus.
Diabetes Mellitus
Pharmacological effects and clinical applications of propionyl-L-carnitine.
Diabetes Mellitus
Prospective evaluation of type 2 diabetes mellitus on the risk of primary liver cancer in Chinese men and women.
Diabetes Mellitus
The association between fasting blood glucose and the risk of primary liver cancer in Chinese males: a population-based prospective study.
Diabetes Mellitus
[Blood CPR levels in diabetes mellitus during insulin therapy, with special reference to the characteristics of PLC (proinsulin-like components) and C-peptide in fractional analysis]
Diabetes Mellitus, Type 1
Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression.
Diabetes Mellitus, Type 1
Reduced guanine nucleotide-stimulated polyphosphoinositide specific phospholipase C in platelet hyperaggregation in IDDM.
Diabetes Mellitus, Type 2
A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene.
Diabetes Mellitus, Type 2
Albiglutide, an albumin-based fusion of glucagon-like peptide 1 for the potential treatment of type 2 diabetes.
Diabetes Mellitus, Type 2
Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study.
Diabetes Mellitus, Type 2
Dapagliflozin, an oral sodium glucose cotransporter type 2 inhibitor for the treatment of type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Hepatic insulin resistance in KKA(y) mice and its amelioration by pioglitazone do not involve alterations in phospholipase C activity.
Diabetes Mellitus, Type 2
Pharmacological effects and clinical applications of propionyl-L-carnitine.
Diabetes Mellitus, Type 2
Prospective evaluation of type 2 diabetes mellitus on the risk of primary liver cancer in Chinese men and women.
Diabetes Mellitus, Type 2
Saxagliptin, a dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Diabetic Cardiomyopathies
Defective sarcolemmal phospholipase C signaling in diabetic cardiomyopathy.
Diabetic Retinopathy
Distribution of peripheral lesions identified by mydriatic ultra-wide field fundus imaging in diabetic retinopathy.
Diabetic Retinopathy
Peripheral Lesions Identified by Mydriatic Ultrawide Field Imaging: Distribution and Potential Impact on Diabetic Retinopathy Severity.
Diphtheria
Entry of diphtheria toxin linked to concanavalin A into primate and murine cells.
Diphtheria
Evidence that membrane phospholipids and protein are required for binding of diphtheria toxin in Vero cells.
Diverticulum
Is the poly (L- lactide- co- caprolactone) nanofibrous membrane suitable for urinary bladder regeneration?
Down Syndrome
Reduced phospholipase C-beta activity and isoform expression in the cerebellum of TS65Dn mouse: a model of Down syndrome.
Dysentery
Effect of divalent cations on hemolysin synthesis by Serpulina (Treponema) hyodysenteriae: inhibition induced by zinc and copper.
Dysentery
Investigation of a hemolysin produced by enteropathogenic Treponema hyodysenteriae.
Dysentery
Reduced virulence of Serpulina hyodysenteriae hemolysin-negative mutants in pigs and their potential to protect pigs against challenge with a virulent strain.
Dyskinesias
Aberrant behavioral effects of a dopamine D1 receptor antagonist and agonist in monkeys: evidence of uncharted dopamine D1 receptor actions.
Dyskinesias
D1-mGlu5 heteromers mediate noncanonical dopamine signaling in Parkinson's disease.
Dyslipidemias
Propolis Reduces Phosphatidylcholine-Specific Phospholipase C Activity and Increases Annexin a7 Level in Oxidized-LDL-Stimulated Human Umbilical Vein Endothelial Cells.
Dysplastic Nevus Syndrome
The impact of total body photography on biopsy rate in patients from a pigmented lesion clinic.
Dyspnea
A Rare Case of Progressive Dyspnea and Bilateral Lung Infiltration in a Young Male.
Dyspnea
Pulmonary lymphangitic carcinomatosis from an oropharyngeal squamous cell carcinoma: a case report.
Dyspnea
Pulmonary lymphangitis carcinomatosis: systematic review and meta-analysis of case reports, 1970-2018.
Dystocia
Administration of acetylsalicylic acid after parturition in lactating dairy cows under certified organic management: Part I. Milk yield, milk components, activity patterns, fertility, and health.
Eclampsia
Platelets from eclampsia patients have reduced membrane microviscosity and lower activities of the signalling enzymes.
Embolism
Cutting xylem under tension or supersaturated with gas can generate PLC and the appearance of rapid recovery from embolism.
Embolism
Effects of xylem embolism on the winter survival of Abies veitchii shoots in an upper subalpine region of central Japan.
Embolism
Hydraulic vulnerability, vessel refilling, and seasonal courses of stem water potential of Sorbus aucuparia L. and Sambucus nigra L.
Embolism
Native root xylem embolism and stomatal closure in stands of Douglas-fir and ponderosa pine: mitigation by hydraulic redistribution.
Embolism
Relax and refill: xylem rehydration prior to hydraulic measurements favours embolism repair in stems and generates artificially low PLC values.
Embolism
Responses of functional traits to seven-year nitrogen addition in two tree species: coordination of hydraulics, gas exchange and carbon reserves.
Embolism
What happens when stems are embolized in a centrifuge? Testing the cavitron theory
Embolism
What happens when stems are embolized in a centrifuge? Testing the cavitron theory.
Embolism
Winter embolism, mechanisms of xylem hydraulic conductivity recovery and springtime growth patterns in walnut and peach trees.
Embolism
Xylem recovery from cavitation-induced embolism in young plants of Laurus nobilis: a possible mechanism.
Empyema
[ON ALPHA HEMOLYSIN IN PUNCTURE FLUID IN THE EARLY DIAGNOSIS OF STAPHYLOCOCCAL EMPYEMA.]
Encephalitis
Genome sequence analysis reveals potential for virulence genes and multi-drug resistance in an Enterococcus faecalis 2A (XJ05) strain that causes lamb encephalitis.
Endocarditis
Beta toxin catalyzes formation of nucleoprotein matrix in staphylococcal biofilms.
Endocarditis
Frequency of Virulence-Associated Genes in Enterococccus faecalis Isolated in Kuwait Hospitals.
Endocarditis
Incidence of hemolysin, gelatinase, and aggregation substance among enterococci isolated from patients with endocarditis and other infections and from feces of hospitalized and community-based persons.
Endocarditis
Plasmid-associated hemolysin and aggregation substance production contribute to virulence in experimental enterococcal endocarditis.
Endometrial Hyperplasia
Phospholipase C activity in human endometrium: its significance in endometrial pathology.
Endometrial Neoplasms
Luteinizing hormone-releasing hormone agonist triptorelin antagonizes signal transduction and mitogenic activity of epidermal growth factor in human ovarian and endometrial cancer cell lines.
Endophthalmitis
Contribution of membrane-damaging toxins to Bacillus endophthalmitis pathogenesis.
Endophthalmitis
Evidence for contribution of tripartite hemolysin BL, phosphatidylcholine-preferring phospholipase C, and collagenase to virulence of Bacillus cereus endophthalmitis.
Endophthalmitis
Extracellular virulence factors in Bacillus cereus endophthalmitis: methods and implication of involvement of hemolysin BL.
Endophthalmitis
Role of hemolysin BL in the pathogenesis of extraintestinal Bacillus cereus infection assessed in an endophthalmitis model.
Endophthalmitis
The dangers of sublethal carvacrol exposure: increases in virulence of Bacillus cereus during endophthalmitis.
Enteritis
A Fast and Inexpensive Protocol for Empirical Verification of Neutralizing Epitopes in Microbial Toxins and Enzymes.
Enteritis
Acute hemorrhagic necrotizing enteritis: a case report and review of the literature.
Enteritis
B-cell epitope of beta toxin of Clostridium perfringens genetically conjugated to a carrier protein: Expression, purification and characterization of the chimeric protein.
Enteritis
Beta toxin is essential for the intestinal virulence of Clostridium perfringens type C disease isolate CN3685 in a rabbit ileal loop model.
Enteritis
Biological activities and pore formation of Clostridium perfringens beta toxin in HL 60 cells.
Enteritis
Clostridium perfringens alpha toxin affects electrophysiological properties of isolated jejunal mucosa of laying hens.
Enteritis
Clostridium perfringens beta toxin DNA prime-protein boost elicits enhanced protective immune response in mice.
Enteritis
Clostridium perfringens in poultry: an emerging threat for animal and public health.
Enteritis
Dissecting the contributions of Clostridium perfringens type C toxins to lethality in the mouse intravenous injection model.
Enteritis
Endothelial Binding of Beta Toxin to Small Intestinal Mucosal Endothelial Cells in Early Stages of Experimentally Induced Clostridium Perfringens Type C Enteritis in Pigs.
Enteritis
Evidence that the Agr-like quorum sensing system regulates the toxin production, cytotoxicity and pathogenicity of Clostridium perfringens type C isolate CN3685.
Enteritis
Evidence That VirS Is a Receptor for the Signaling Peptide of the Clostridium perfringens Agr-like Quorum Sensing System.
Enteritis
In vitro lecithinase activity and sensitivity to 22 antimicrobial agents of Clostridium perfringens isolated from necrotic enteritis of broiler chickens.
Enteritis
Molecular docking analysis of P2X7 receptor with the beta toxin from Clostridium perfringens.
Enteritis
NetB, a New Toxin That Is Associated with Avian Necrotic Enteritis Caused by Clostridium perfringens.
Enteritis
Sequence variation in the alpha-toxin encoding plc gene of Clostridium perfringens strains isolated from diseased and healthy chickens.
Enteritis
Synergistic effects of Clostridium perfringens enterotoxin and beta toxin in rabbit small intestinal loops.
Enteritis
The successful experimental induction of necrotic enteritis in chickens by Clostridium perfringens: a critical review.
Enteritis
The VirS/VirR Two-Component System Regulates the Anaerobic Cytotoxicity, Intestinal Pathogenicity, and Enterotoxemic Lethality of Clostridium perfringens Type C Isolate CN3685.
Enteritis
Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease.
Enterocolitis
Humoral Immune Response Evaluation in Horses Vaccinated with Recombinant Clostridium perfringens Toxoids Alpha and Beta for 12 Months.
Enterocolitis
Structure and functional characterization of Vibrio parahaemolyticus thermostable direct hemolysin (TDH).
Enterotoxemia
Evaluation of enzyme-linked immunosorbent assay for diagnosis of Clostridium perfringens enterotoxemias.
Enterotoxemia
Evidence That VirS Is a Receptor for the Signaling Peptide of the Clostridium perfringens Agr-like Quorum Sensing System.
Enterotoxemia
The effect of Clostridium perfringens type C strain CN3685 and its isogenic beta toxin null mutant in goats.
Enterotoxemia
The VirS/VirR Two-Component System Regulates the Anaerobic Cytotoxicity, Intestinal Pathogenicity, and Enterotoxemic Lethality of Clostridium perfringens Type C Isolate CN3685.
Epilepsies, Partial
Pathological laughter as prodromal manifestation of transient ischemic attacks--case report and brief review.
Epilepsy
The Role of Phospholipase C in GABAergic Inhibition and Its Relevance to Epilepsy.
Epstein-Barr Virus Infections
Epstein-Barr virus protein LMP2A regulates reactivation from latency by negatively regulating tyrosine kinases involved in sIg-mediated signal transduction.
Erectile Dysfunction
Stimulation of femoral trabecular bone growth in ovariectomized rats by human parathyroid hormone (hPTH)-(1-30)NH(2).
Escherichia coli Infections
Endotoxin "priming" potentiates lung vascular abnormalities in response to Escherichia coli hemolysin: an example of synergism between endo- and exotoxin.
Escherichia coli Infections
Hemolytically active (acylated) alpha-hemolysin elicits interleukin-1beta (IL-1beta) but augments the lethality of Escherichia coli by an IL-1- and tumor necrosis factor-independent mechanism.
Escherichia coli Infections
Impact of arachidonic versus eicosapentaenoic acid on exotonin-induced lung vascular leakage: relation to 4-series versus 5-series leukotriene generation.
Escherichia coli Infections
Nitric oxide biosynthesis in an exotoxin-induced septic lung model: role of cNOS and impact on pulmonary hemodynamics.
Escherichia coli Infections
Severe VA/Q mismatch in perfused lungs evoked by sequential challenge with endotoxin and E. coli hemolysin.
Escherichia coli Infections
Thromboxane-mediated hypertension and vascular leakage evoked by low doses of Escherichia coli hemolysin in rabbit lungs.
Esophageal Neoplasms
Phospholipase C ?-1 gene polymorphisms and prognosis of esophageal cancer patients from a high-incidence region in northern China.
Esophageal Squamous Cell Carcinoma
Characterization of a novel tumor-suppressor gene PLC delta 1 at 3p22 in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Low PLCE1 levels are correlated with poor prognosis in hepatocellular carcinoma.
Esophageal Squamous Cell Carcinoma
Phospholipase C ?-1 gene polymorphisms and prognosis of esophageal cancer patients from a high-incidence region in northern China.
Esophageal Squamous Cell Carcinoma
Role of novel and GWAS originated PLCE1 genetic variants in susceptibility and prognosis of esophageal cancer patients in northern Indian population.
Essential Hypertension
Dopamine-1 receptor coupling defect in renal proximal tubule cells in hypertension.
Essential Hypertension
Phospholipase C activity is enhanced in skin fibroblasts obtained from patients with essential hypertension.
Eye Neoplasms
Secondary Somatic Mutations in G-Protein-Related Pathways and Mutation Signatures in Uveal Melanoma.
Facial Paralysis
Pathological laughter and crying: insights from lesion network-symptom-mapping.
Fatty Liver
Expanding the Liver Imaging Reporting and Data System (LI-RADS) v2018 diagnostic population: performance and reliability of LI-RADS for distinguishing hepatocellular carcinoma (HCC) from non-HCC primary liver carcinoma in patients who do not meet strict LI-RADS high-risk criteria.
Fatty Liver
Perceived dietary salt intake and the risk of primary liver cancer: a population-based prospective study.
Foodborne Diseases
Antibiotic Sensitivity of Clostridium perfringens Isolated From Faeces in Tabriz, Iran.
Foodborne Diseases
Binding to The Target Cell Surface Is The Crucial Step in Pore Formation of Hemolysin BL from Bacillus cereus.
Foodborne Diseases
Characteristics of the Protein Complexes and Pores Formed by Bacillus cereus Hemolysin BL.
Foodborne Diseases
Detection of viable enterotoxin-producing Bacillus cereus and analysis of toxigenicity from ready-to-eat foods and infant formula milk powder by multiplex PCR.
Foodborne Diseases
Glycan specificity of the Vibrio vulnificus hemolysin lectin outlines evolutionary history of membrane targeting by a toxin family.
Foodborne Diseases
Isolation of Alpha-Toxin-Deficient Clostridium perfringens Type F from Sewage Influents and Effluents.
Foodborne Diseases
Modulation of Vibrio mimicus hemolysin through limited proteolysis by an endogenous metalloprotease.
Foodborne Diseases
Molecular cloning and characterization of the genes encoding the L1 and L2 components of hemolysin BL from Bacillus cereus.
Foodborne Diseases
Multifaceted toxin profile, an approach toward a better understanding of probiotic Bacillus cereus.
Foodborne Diseases
NMR structure of the Bacillus cereus hemolysin II C-terminal domain reveals a novel fold.
Foodborne Diseases
Occurrence of urease-positive Vibrio parahaemolyticus in Kanagawa, Japan, with specific reference to presence of thermostable direct hemolysin (TDH) and the TDH-related-hemolysin genes.
Foodborne Diseases
Pathogenesis of Vibrio parahaemolyticus: intraperitoneal and orogastric challenge experiments in mice.
Foodborne Diseases
Production of hemolysin BL by Bacillus cereus group isolates of dairy origin is associated with whole-genome phylogenetic clade.
Foodborne Diseases
Purification and some properties of a Bacillus cereus mouse lethal toxin.
Foodborne Diseases
Studies on enterotoxigenic Bacillus cereus in raw milk and some dairy products
Foodborne Diseases
Time course of virulence factors produced by group A streptococcus during a food-borne epidemic.
Foodborne Diseases
Urea hydrolysis and suppressed production of thermostable direct hemolysin (TDH) by Vibrio parahaemolyticus associated with presence of TDH-related hemolysin genes.
Foodborne Diseases
X-ray crystal structure of the B component of Hemolysin BL from Bacillus cereus.
Frontotemporal Dementia
A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.
Frontotemporal Dementia
Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.
Furunculosis
Antibody response to alpha- and betahemolysin from Staphylococcus aureus in patients with staphylococcal infections and in normals.
Furunculosis
Identification of major common extracellular proteins secreted by Aeromonas salmonicida strains isolated from diseased fish.
Gallstones
Effect of phospholipase C on cholesterol solubilization in model bile. A concanavalin A-binding nucleation-promoting factor from human gallbladder bile.
Gallstones
Identification of a phosphatidylcholine active phospholipase C in human gallbladder bile.
Gangliosidoses
Altered phosphoinositide-specific phospholipase C and adenylyl cyclase in brain cortical membranes of cats with GM1 and GM2 gangliosidosis.
Gas Gangrene
A cellular deficiency of gangliosides causes hypersensitivity to Clostridium perfringens phospholipase C.
Gas Gangrene
Alpha toxin from Clostridium perfringens induces proinflammatory changes in endothelial cells.
Gas Gangrene
Clostridial gas gangrene. I. Cellular and molecular mechanisms of microvascular dysfunction induced by exotoxins of Clostridium perfringens.
Gas Gangrene
Clostridium absonum alpha-toxin: new insights into clostridial phospholipase C substrate binding and specificity.
Gas Gangrene
Clostridium perfringens Alpha-Toxin Induces Gm1a Clustering and Trka Phosphorylation in the Host Cell Membrane.
Gas Gangrene
Clostridium perfringens phospholipase C induced ROS production and cytotoxicity require PKC, MEK1 and NF?B activation.
Gas Gangrene
Clostridium perfringens phospholipase C-induced platelet/leukocyte interactions impede neutrophil diapedesis.
Gas Gangrene
Cross-complementation of Clostridium perfringens PLC and Clostridium septicum alpha-toxin mutants reveals PLC is sufficient to mediate gas gangrene.
Gas Gangrene
Enhanced production of phospholipase C and perfringolysin O (alpha and theta toxins) in a gatifloxacin-resistant strain of Clostridium perfringens.
Gas Gangrene
Ethanolamine utilization supports Clostridium perfringens growth in infected tissues.
Gas Gangrene
Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene.
Gas Gangrene
Immunization of rabbits with recombinant Clostridium perfringens alpha toxins CPA-C and CTB-CPA-C in a bicistronic design expression system confers strong protection against challenge.
Gas Gangrene
Immunization with a nontoxic naturally occurring Clostridium perfringens alpha toxin induces neutralizing antibodies in rabbits.
Gas Gangrene
Immunization with the C-Domain of alpha -Toxin prevents lethal infection, localizes tissue injury, and promotes host response to challenge with Clostridium perfringens.
Gas Gangrene
Internalization of Clostridium perfringens ?-toxin leads to ERK activation and is involved on its cytotoxic effect.
Gas Gangrene
Role of Clostridium perfringens phospholipase C in the pathogenesis of gas gangrene.
Gas Gangrene
Sugar inhibits the production of the toxins that trigger clostridial gas gangrene.
Gas Gangrene
The biochemistry of the gas gangrene toxins; the reaction between the alpha-toxin, lecithinase, of Clostridium welchii and its antitoxin.
Gas Gangrene
The first strain of Clostridium perfringens isolated from an avian source has an alpha-toxin with divergent structural and kinetic properties.
Gas Gangrene
The Oncopathic Potency of Clostridium perfringens Is Independent of Its alpha-Toxin Gene.
Gas Gangrene
Unexpected wide substrate specificity of C. perfringens ?-toxin phospholipase C.
Gas Gangrene
Virulence studies on chromosomal alpha-toxin and theta-toxin mutants constructed by allelic exchange provide genetic evidence for the essential role of alpha-toxin in Clostridium perfringens-mediated gas gangrene.
Gas Gangrene
[Comparative study of leukotoxic, hemolytic and lecithinase activity of toxins of basic causative organisms of gas gangrene.]
Gas Gangrene
[Morphological erythrocyte changes due to alpha and theta hemolysin due to gas gangrene toxin.]
Gas Gangrene
[On the role of lecithinase C in creating immunity to gas gangrene under experimental conditions]
Gastroenteritis
A novel extracellular protease of Vibrio mimicus that mediates maturation of an endogenous hemolysin.
Gastroenteritis
Calcium-dependent intestinal chloride secretion by Vibrio parahaemolyticus thermostable direct hemolysin in a rabbit model.
Gastroenteritis
Characteristics of alpha-hemolytic strains of Escherichia coli isolated from dogs with gastroenteritis.
Gastroenteritis
Cloning and expression of two genes encoding highly homologous hemolysins from a Kanagawa phenomenon-positive Vibrio parahaemolyticus T4750 strain.
Gastroenteritis
Cloning and nucleotide sequence of the gene (trh) encoding the hemolysin related to the thermostable direct hemolysin of Vibrio parahaemolyticus.
Gastroenteritis
Contribution of Vibrio parahaemolyticus virulence factors to cytotoxicity, enterotoxicity, and lethality in mice.
Gastroenteritis
Modulation of Vibrio mimicus hemolysin through limited proteolysis by an endogenous metalloprotease.
Gastroenteritis
Molecular cloning and characterization of the hblA gene encoding the B component of hemolysin BL from Bacillus cereus.
Gastroenteritis
Molecular epidemiologic evidence for association of thermostable direct hemolysin (TDH) and TDH-related hemolysin of Vibrio parahaemolyticus with gastroenteritis.
Gastroenteritis
QsvR integrates into quorum sensing circuit to control Vibrio parahaemolyticus virulence.
Gastroenteritis
Quantitative microbiological risk assessment of complex microbial community in Prawn farm wastewater and applicability of nanoparticles and probiotics for eliminating of antibiotic-resistant bacteria.
Gastroenteritis
Sensitively and quickly detecting Vibrio vulnificus by real time recombinase polymerase amplification targeted to vvhA gene.
Gastroenteritis
Urease-positive, Kanagawa-negative Vibrio parahaemolyticus from patients and the environment in the Pacific Northwest.
Gastroesophageal Reflux
Lesogaberan, a GABA(B) agonist for the potential treatment of gastroesophageal reflux disease.
Gastrointestinal Diseases
Vibrio parahaemolyticus (Kanagawa-negative) wound infection in a hospital dietary employee.
Gastrointestinal Diseases
VP1686, a Vibrio type III secretion protein, induces toll-like receptor-independent apoptosis in macrophage through NF-kappaB inhibition.
Gastrointestinal Hemorrhage
Acute hemorrhagic necrotizing enteritis: a case report and review of the literature.
Genetic Diseases, Inborn
Structural organization and expression of the human phosphatidylinositol-specific phospholipase C beta-3 gene.
Genetic Diseases, Inborn
[A new auto-inflammatory genetic disease associated with cold urticaria: Plaid involving PLCG2 mutation].
Genital Diseases
TA-CIN, a vaccine incorporating a recombinant HPV fusion protein (HPV16 L2E6E7) for the potential treatment of HPV16-associated genital diseases.
Geographic Atrophy
Statistical driver genes as a means to uncover missing heritability for age-related macular degeneration.
Glaucoma
Chronic Intraocular Inflammation as a Risk Factor for XEN Gel Stent Occlusion: A Case of Microscopic Examination of a Fibrin-obstructed XEN Stent.
Glaucoma
Efficacy of the XEN gel stent on intraocular pressure lowering in East Asian eyes.
Glaucoma
Outcomes of Gel Stent Implantation for Glaucoma in Patients With Previous Corneal Graft Surgery: A Case Series.
Glaucoma
XEN glaucoma treatment system in the management of refractory glaucomas: a short review on trial data and potential role in clinical practice.
Glioblastoma
Activation of neuromedin B-preferring bombesin receptors on rat glioblastoma C-6 cells increases cellular Ca2+ and phosphoinositides.
Glioblastoma
Kinomic profiling of glioblastoma cells reveals PLCG1 as a target in restricted glucose.
Glioblastoma
Kisspeptin Promotes Glioblastoma Cell Invasiveness Via the Gq-PLC-PKC Pathway.
Glioblastoma
miR-423-5p inhibits the proliferation and metastasis of glioblastoma cells by targeting phospholipase C beta 1.
Glioma
(1)H HR-MAS and genomic analysis of human tumor biopsies discriminate between high and low grade astrocytomas.
Glioma
ADP-evoked phospholipase C stimulation and adenylyl cyclase inhibition in glioma C6 cells occur through two distinct nucleotide receptors, P2Y(1) and P2Y(12).
Glioma
Astroglial membrane structure is affected by agents that raise cyclic AMP and by phosphatidylcholine phospholipase C.
Glioma
Baicalin and baicalein, constituents of an important medicinal plant, inhibit intracellular Ca2+ elevation by reducing phospholipase C activity in C6 rat glioma cells.
Glioma
Cross-talk between beta-adrenergic and metabotropic glutamate receptors in rat C6 glioma cells.
Glioma
Differential effects of P2-purinoceptor antagonists on phospholipase C- and adenylyl cyclase-coupled P2Y-purinoceptors.
Glioma
Differential effects of P2Y1 and P2Y12 nucleotide receptors on ERK1/ERK2 and phosphatidylinositol 3-kinase signalling and cell proliferation in serum-deprived and nonstarved glioma C6 cells.
Glioma
Differential expression of phospholipase C specific for inositol phospholipids at the cell surface of rat glial cells and REF52 rat embryo fibroblasts.
Glioma
Effect of ethanol on ATP-induced phospholipases C and D and serine base exchange in glioma C6 cells.
Glioma
Effect of nordihydroguaiaretic acid on intracellular Ca(2+) concentrations in C6 glioma cells.
Glioma
Effects of 2-azafluorenones on phosphatidyl-inositol specific phospholipase C activation in c6 glioma cells.
Glioma
Effects of insulin on glucose uptake in cultured cells from the central nervous system of rodent.
Glioma
Endothelin-1 stimulates c-fos mRNA expression in C6 glioma cells via MAP kinase pathway.
Glioma
Ethanol-induced alteration in activities of cerebral phosphatidylinositol 4,5-biphosphate-specific and cytosolic phospholipase C in the brain: analysis using NG 108-15 cells and brains from ethanol-inhaled mice.
Glioma
Expression of phosphoinositide-specific phospholipase C isoenzymes in cultured astrocytes.
Glioma
Heterogeneity of nucleotide receptors in NG108-15 neuroblastoma and C6 glioma cells for mediating phosphoinositide turnover.
Glioma
Homologous desensitization of histamine-mediated signal transduction system in C6 glioma cells.
Glioma
Increased diacylglycerol levels inhibit [20-3H]phorbol 12,13-dibutyrate binding and the glucocorticoid-mediated increase in glycerol phosphate phosphate dehydrogenase levels in C6 rat glioma cells.
Glioma
Inositol trisphosphate/Ca2+ as messengers of bradykinin B2 and muscarinic acetylcholine m1-m4 receptors in neuroblastoma-derived hybrid cells.
Glioma
Limited metabolic interaction of serine with ethanolamine and choline in the turnover of phosphatidylserine, phosphatidylethanolamine and plasmalogens in cultured glioma cells.
Glioma
Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction.
Glioma
Molecular mechanisms for the activation of Ca2+-permeable nonselective cation channels by endothelin-1 in C6 glioma cells.
Glioma
Pharmacological and second messenger signalling selectivities of cloned P2Y receptors.
Glioma
Phosphatidylcholine-specific phospholipase C inhibition down- regulates CXCR4 expression and interferes with proliferation, invasion and glycolysis in glioma cells.
Glioma
Phospholipase C Beta 1: a Candidate Signature Gene for Proneural Subtype High-Grade Glioma.
Glioma
Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor.
Glioma
Sitimagene ceradenovec: a gene-based drug for the treatment of operable high-grade glioma.
Glioma
Sphingosine modulates Ca2+ signals via phospholipase C dependent pathway in glioma C6 cells.
Glioma
Suppression of phospholipase C blocks Gi-mediated inhibition of adenylyl cyclase activity.
Glioma
SYK Inhibition Blocks Proliferation and Migration of Glioma Cells, and Modifies the Tumor Microenvironment.
Glioma
The C6-2B glioma cell P2Y(AC) receptor is pharmacologically and molecularly identical to the platelet P2Y(12) receptor.
Glioma
The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity.
Glioma
Tissue- and cell type-specific expression of mRNAs for four types of inositol phospholipid-specific phospholipase C.
Glioma
Zinc homeostasis in C6 glioma cells: phospholipase C activity regulates cellular zinc export.
Goiter
Thyroid-stimulating hormone activates phospholipase C in normal and neoplastic thyroid tissue.
Granuloma
IN VIVO AND IN VITRO IMMUNOMODULATORY AND ANTI-INFLAMMATORY EFFECTS OF TOTAL FLAVONOIDS OF ASTRAGALUS.
Granuloma
Inhibitory effects of propionyl-L-carnitine on plasma extravasation induced by irritants in rodents.
Granuloma
Phospholipase C?2 Is Required for Luminal Expansion of the Epididymal Duct during Postnatal Development in Mice.
Graves Disease
Immunoglobulins from Graves' disease patients stimulate phospholipase A2 and C systems in FRTL-5 and human thyroid cells.
Growth Hormone-Secreting Pituitary Adenoma
Phorbol ester and phospholipase C-induced growth hormone secretion from pituitary somatotroph adenoma cells in culture: effects of somatostatin, bromocriptine, and pertussis toxin.
Heart Diseases
[The promoting research of phospholipase C epsilon-1 on nasal Th2 cell polarization].
Heart Failure
Alterations in Ca2+ cycling proteins and G alpha q signaling after left ventricular assist device support in failing human hearts.
Heart Failure
Changes in sarcolemmal PLC isoenzymes in postinfarct congestive heart failure: partial correction by imidapril.
Heart Failure
Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders.
Heart Failure
Depressed responsiveness of phospholipase C isoenzymes to phosphatidic acid in congestive heart failure.
Heart Failure
Exercise intolerance during post-MI heart failure in rats: prevention with supplemental dietary propionyl-L-carnitine.
Heart Failure
Identification of changes in cardiac phospholipase C activity in congestive heart failure.
Heart Failure
Improvement of cardiac function and beta-adrenergic signal transduction by propionyl L-carnitine in congestive heart failure due to myocardial infarction.
Heart Failure
Interleukin-1beta mediates endotoxin- and tumor necrosis factor alpha-induced RGS16 protein expression in cultured cardiac myocytes.
Heart Failure
Phospholipase C gene expression, protein content, and activities in cardiac hypertrophy and heart failure due to volume overload.
Heart Failure
Phospholipase C-delta1 rescues intracellular Ca2+ overload in ischemic heart and hypoxic neonatal cardiomyocytes.
Heart Failure
The propionyl-L-carnitine hypothesis: an alternative approach to treating heart failure.
Helicobacter Infections
[Association between Helicobacter infection in liver tissue and primary liver carcinoma]
Hemangiosarcoma
A recurrent activating PLCG1 mutation in cardiac angiosarcomas increases apoptosis resistance and invasiveness of endothelial cells.
Hemangiosarcoma
Incidence of primary liver cancer and aetiological aspects: a study of a defined population from a low-endemicity area.
Hemangiosarcoma
Phospholipase C gamma 1 (PLCG1) R707Q mutation is counterselected under targeted therapy in a patient with hepatic angiosarcoma.
Hemangiosarcoma
Recurrent CIC Gene Abnormalities in Angiosarcomas: A Molecular Study of 120 Cases With Concurrent Investigation of PLCG1, KDR, MYC, and FLT4 Gene Alterations.
Hemochromatosis
Aetiological aspects on primary liver cancer with special regard to alcohol, organic solvents and acute intermittent porphyria--an epidemiological investigation.
Hemochromatosis
The role of diabetes in hepatocellular carcinoma: a case-control study among United States Veterans.
Hemoglobinuria
Autoimmune hemolytic anemia with hemoglobinemia and hemoglobinuria in the absence of a demonstrable hemolysin or complement-binding antibody.
Hemoglobinuria
LPS directly induces oxygen radical production in human monocytes via LPS binding protein and CD14.
Hemoglobinuria
Mycoplasma pneumoniae infection complicated by paroxysmal cold hemoglobinuria with anti-P specificity of biphasic hemolysin.
Hemoglobinuria
Paroxysmal cold hemoglobinuria (P.C.H.) following mycoplasma infection: anti-I specificity of the biphasic hemolysin.
Hemoglobinuria
Paroxysmal cold hemoglobinuria. Case report with characterization of the Donath-Landsteiner hemolysin.
Hemoglobinuria
Rituximab as successful therapy in a patient with refractory paroxysmal cold hemoglobinuria.
Hemoglobinuria
Serologic properties of a cold hemolysin and an acid hemolysin occurring in a case of syphilitic paroxysmal cold hemoglobinuria.
Hemoglobinuria
The Fc-receptor III of cultured human monocytes. Structural similarity with FcRIII of natural killer cells and role in the extracellular lysis of sensitized erythrocytes.
Hemoglobinuria
[A case of paroxysmal cold hemoglobinuria with thrombocytopenia (Evans' syndrome), and without anti-P specificity of biphasic hemolysin]
Hemoglobinuria
[On the anti-TJa specificity of biphasic hemolysin in a case of paroxysmal cold hemoglobinuria]
Hemoglobinuria
[Paroxysmal cold hemoglobinuria caused by biphasic anti-IH-specific hemolysin]
Hemoglobinuria, Paroxysmal
An anti-i biphasic hemolysin in chronic paroxysmal cold hemoglobinuria.
Hemoglobinuria, Paroxysmal
FREE ANTIGEN AND ANTIBODY CIRCULATING TOGETHER IN LARGE AMOUNTS (HEMAGGLUTININ AND AGGLUTINOGEN IN THE BLOOD OF TRANSFUSED RABBITS).
Hemoglobinuria, Paroxysmal
LPS directly induces oxygen radical production in human monocytes via LPS binding protein and CD14.
Hemoglobinuria, Paroxysmal
Mycoplasma pneumoniae infection complicated by paroxysmal cold hemoglobinuria with anti-P specificity of biphasic hemolysin.
Hemoglobinuria, Paroxysmal
Paroxysmal cold hemoglobinuria (P.C.H.) following mycoplasma infection: anti-I specificity of the biphasic hemolysin.
Hemoglobinuria, Paroxysmal
Paroxysmal cold hemoglobinuria. Case report with characterization of the Donath-Landsteiner hemolysin.
Hemoglobinuria, Paroxysmal
Paroxysmal hemoglobinuria due to the cold hemolysin; observations with a report of a case of its occurence in an aerial gunner.
Hemoglobinuria, Paroxysmal
Rituximab as successful therapy in a patient with refractory paroxysmal cold hemoglobinuria.
Hemoglobinuria, Paroxysmal
Serologic properties of a cold hemolysin and an acid hemolysin occurring in a case of syphilitic paroxysmal cold hemoglobinuria.
Hemoglobinuria, Paroxysmal
The Fc-receptor III of cultured human monocytes. Structural similarity with FcRIII of natural killer cells and role in the extracellular lysis of sensitized erythrocytes.
Hemoglobinuria, Paroxysmal
[A case of paroxysmal cold hemoglobinuria with thrombocytopenia (Evans' syndrome), and without anti-P specificity of biphasic hemolysin]
Hemoglobinuria, Paroxysmal
[On the anti-TJa specificity of biphasic hemolysin in a case of paroxysmal cold hemoglobinuria]
Hemoglobinuria, Paroxysmal
[Paroxysmal cold hemoglobinuria caused by biphasic anti-IH-specific hemolysin]
Hemolytic-Uremic Syndrome
Molecular analysis of the plasmid-encoded hemolysin of Escherichia coli O157:H7 strain EDL 933.
Hemoptysis
The powered vascular staple (PVS) versus conventional powered linier cutter (PLC) for the application of bronchial transection in thoracoscopic anatomic segmentectomy.
Hemosiderosis
Quantification of siderophore and hemolysin from Stachybotrys chartarum strains, including a strain isolated from the lung of a child with pulmonary hemorrhage and hemosiderosis.
Hepatitis
Epidemiology of primary liver cancer in serbia and possible connection with cyanobacterial blooms.
Hepatitis
Global incidence trends in primary liver cancer by age at diagnosis, sex, region, and etiology, 1990-2017.
Hepatitis
Incidence of primary liver cancer and aetiological aspects: a study of a defined population from a low-endemicity area.
Hepatitis
Individuals having variant genotypes of cytochrome P450 2C19 are at increased risk of developing primary liver cancer in Han populations, without infection with the hepatitis virus.
Hepatitis
Oncogenic driver genes and tumor microenvironment determine the type of liver cancer.
Hepatitis
[Clinicopathologic characteristics of primary liver cancer in patients younger than 35 years]
Hepatitis
[Longitudinal study of aflatoxin exposure in the development of primary liver cancer in patients with chronic hepatitis].
Hepatitis
[Prospective study of liver parenchyma volume in hepatectomy of primary liver cancer]
Hepatitis
[Serum glycoprotein profiling by lectin affinity microarray to distinguish the various stages of primary liver carcinogenesis].
Hepatitis B
Aflatoxin as a cause of primary liver-cell cancer in the United States: a probability study.
Hepatitis B
Aflatoxin is not a probably human carcinogen: the published evidence is sufficient.
Hepatitis B
Body Mass Index and Risk of Primary Liver Cancer: A Meta-Analysis of Prospective Studies.
Hepatitis B
Characteristics and prognosis of primary liver cancer in young patients in China.
Hepatitis B
Correlations of pri-Let-7 gene polymorphisms with the recurrence and metastasis of primary liver cancer after transcatheter arterial chemoembolization.
Hepatitis B
Diagnostic and prognostic value of mRNA expression of phospholipase C ? family genes in hepatitis B virus?associated hepatocellular carcinoma.
Hepatitis B
Global incidence trends in primary liver cancer by age at diagnosis, sex, region, and etiology, 1990-2017.
Hepatitis B
HBs-Ag-negative hepatitis in a hemodialysis unit: relation to Epstein-Barr virus.
Hepatitis B
Hepatitis B surface antigen and alpha-fetoprotein secreting human primary liver cell cancer in athymic mice.
Hepatitis B
Hepatitis B virus and primary liver cancer on Chongming Island, People's Republic of China.
Hepatitis B
Immunohistochemical characterization of 130 cases of primary hepatic carcinomas.
Hepatitis B
Nonassociation of aflatoxin with primary liver cancer in a cross-sectional ecological survey in the People's Republic of China.
Hepatitis B
Occurrence of cirrhosis and primary liver cancer in an Eskimo population hyperendemically infected with hepatitis B virus.
Hepatitis B
Primary liver carcinoma and liver cirrhosis in atomic bomb survivors, Hiroshima and Nagasaki, 1961-75, with special reference to hepatitis B surface antigen.
Hepatitis B
Protective role of selenium against hepatitis B virus and primary liver cancer in Qidong.
Hepatitis B
Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer.
Hepatitis B
Reduced Aflatoxin Exposure Presages Decline in Liver Cancer Mortality in an Endemic Region of China.
Hepatitis B
Waist Circumference Might Be a Predictor of Primary Liver Cancer: A Population-Based Cohort Study.
Hepatitis B
[A thirty-one year prospective follow-up program on the HBsAg carrier state and primary liver cancer in Qidong, China.]
Hepatitis B
[Clinicopathologic characteristics of primary liver cancer in patients younger than 35 years]
Hepatitis B
[Correlation between polymorphisms in the human leukocyte antigen-DQB1 alleles and hepatitis B with primary hepatocellular carcinoma].
Hepatitis B
[Hepatitis B virus and primary liver carcinoma: evidences for a filiation hepatitis B, cirrhosis and primary liver cancer.]
Hepatitis B
[Serum glycoprotein profiling by lectin affinity microarray to distinguish the various stages of primary liver carcinogenesis].
Hepatitis B, Chronic
[Guideline for stratified screening and surveillance of primary liver cancer(2020 Edition)].
Hepatitis C
Body Mass Index and Risk of Primary Liver Cancer: A Meta-Analysis of Prospective Studies.
Hepatitis C
Expanding the Liver Imaging Reporting and Data System (LI-RADS) v2018 diagnostic population: performance and reliability of LI-RADS for distinguishing hepatocellular carcinoma (HCC) from non-HCC primary liver carcinoma in patients who do not meet strict LI-RADS high-risk criteria.
Hepatitis C
Global incidence trends in primary liver cancer by age at diagnosis, sex, region, and etiology, 1990-2017.
Hepatitis C
Host factor prioritization for pan-viral genetic perturbation screens using random intercept models and network propagation.
Hepatitis C
Incidence of primary liver cancer in Italy between 1988 and 2002: an age-period-cohort analysis.
Hepatitis C
The role of diabetes in hepatocellular carcinoma: a case-control study among United States Veterans.
Hepatitis C, Chronic
In situ expression patterns of melanoma inhibitory activity 2 in healthy and diseased livers.
Hepatitis, Autoimmune
The role of diabetes in hepatocellular carcinoma: a case-control study among United States Veterans.
Hepatitis, Chronic
Spontaneous and iatrogenic spreading of liver-derived cells into peripheral blood of patients with primary liver cancer.
Hepatitis, Chronic
Temporal changes in liver cancer incidence rates in Japan: accounting for death certificate inaccuracies and improving diagnostic techniques.
Hepatitis, Chronic
[Clinical implications of spontaneous and iatrogenic dissemination of tumor cells in patients with primary liver cancer]
Hepatoblastoma
Incidence of primary liver cancer and aetiological aspects: a study of a defined population from a low-endemicity area.
Herpes Simplex
Sitimagene ceradenovec: a gene-based drug for the treatment of operable high-grade glioma.
Herpes Zoster
A role for protein tyrosine kinase in the steroidogenic pathway of angiotensin II in bovine zona glomerulosa cells.
Herpes Zoster
Effects of alpha-melanocyte-stimulating hormone on the cyclic AMP and phospholipid metabolism of rat adrenocortical cells.
Herpes Zoster
Endogenous ligands of PACAP/VIP receptors in the autocrine-paracrine regulation of the adrenal gland.
Herpes Zoster
Investigation of some antimicrobial procedures on the in vitro development of early murine embryos aimed toward developing methods for the disinfection of mammalian embryos prior to transfer.
Herpes Zoster
Isolation of New Delhi metallo-?-lactamase 1 (NDM-1)-producing Vibrio cholerae non-O1, non-O139 strain carrying ctxA, st, and hly genes in southern Vietnam.
Herpes Zoster
Phospholipase Cdelta4 associates with glutamate receptor interacting protein 1 in testis.
Herpes Zoster
Steroidogenic effect of exogenous phospholipase C on bovine adrenal fasciculata cells.
Herpes Zoster
Varicella zoster virus as a possible trigger for the development of pityriasis lichenoides et varioliformis acuta: retrospective analysis of our institutional cases.
HIV Infections
Are Candida albicans isolates from the oral cavity of HIV-infected patients more virulent than from non-HIV-infected patients? Systematic review and meta-analysis.
Hodgkin Disease
Atypical manifestations of pityriasis lichenoides chronica: development into paraneoplasia and non-Hodgkin lymphomas of the skin.
Holoprosencephaly
Mutations in phospholipase C eta-1 (PLCH1) are associated with holoprosencephaly.
Huntington Disease
TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease.
Hyperalgesia
Activation of ?1 adrenoceptors in ventrolateral orbital cortex attenuates allodynia induced by spared nerve injury in rats.
Hyperalgesia
Acute thermal hyperalgesia in the rat is produced by activation of N-methyl-D-aspartate receptors and protein kinase C and production of nitric oxide.
Hyperalgesia
Anti-allodynic effect of intracerebroventricularly administered antioxidant and free radical scavenger in a mouse model of orofacial pain.
Hyperalgesia
Characterization of distinct phospholipases mediating bradykinin and noradrenaline hyperalgesia.
Hyperalgesia
H1-receptor stimulation induces hyperalgesia through activation of the phospholipase C-PKC pathway.
Hyperalgesia
Mechanical hyperalgesia induced by endothelin-1 in rats is mediated via phospholipase C, protein kinase C, and MAP kinases.
Hyperalgesia
Pain Facilitation and Activity-Dependent Plasticity in Pain Modulatory Circuitry: Role of BDNF-TrkB Signaling and NMDA Receptors.
Hyperalgesia
Peripheral prostaglandin E2 prolongs the sensitization of nociceptive dorsal root ganglion neurons possibly by facilitating the synthesis and anterograde axonal trafficking of EP4 receptors.
Hyperalgesia
Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane.
Hyperalgesia
PLC-beta 3 signals upstream of PKC epsilon in acute and chronic inflammatory hyperalgesia.
Hyperalgesia
Protein kinase D isoforms are expressed in rat and mouse primary sensory neurons and are activated by agonists of protease-activated receptor 2.
Hyperalgesia
Supraspinal Gbetagamma-dependent stimulation of PLCbeta originating from G inhibitory protein-mu opioid receptor-coupling is necessary for morphine induced acute hyperalgesia.
Hypercalcemia
Cinacalcet Rectifies Hypercalcemia in a Patient With Familial Hypocalciuric Hypercalcemia Type 2 (FHH2) Caused by a Germline Loss-of-Function G?11 Mutation.
Hypercholesterolemia
Sequestration of aggregated LDL by macrophages studied with freeze-etch electron microscopy.
Hyperemia
Addition of pioglitazone and ramipril to intensive insulin therapy in type 2 diabetic patients improves vascular dysfunction by different mechanisms.
Hyperemia
Propionyl-L-Carnitine Improves Endothelial Function, Microcirculation and Pain Management in Critical Limb Ischemia.
Hyperglycemia
Desensitization of the pancreatic beta-cell: effects of sustained physiological hyperglycemia and potassium.
Hyperglycemia
Hexosamine pathway is responsible for inhibition by diabetes of phenylephrine-induced inotropy.
Hyperinsulinism
Serum and pancreatic immunoreactive insulin (IRI) and proinsulin-like component (PLC), serum IRI and PLC response to different stimuli in normal subjects and organic hyperinsulinism.
Hyperkalemia
Desensitization of the pancreatic beta-cell: effects of sustained physiological hyperglycemia and potassium.
Hyperkalemia
Hemolysis and hyperpotassemia in rat induced by the thermostable direct hemolysin of Vibrio parahaemolyticus.
Hyperlipidemias
Phospholipase C sensitive FVII activity and FVII antigen in hypertriglyceridemia.
Hyperlipidemias
The use of hemolysin inhibition in the study of experimental and clinical hyperlipemia; the non-specific inhibition of streptolysin O, by serum lipoproteins.
Hyperparathyroidism
Hyperparathyroidism of multiple endocrine neoplasia type 1: candidate gene and parathyroid calcium sensing protein expression.
Hypersensitivity
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1.
Hypersensitivity
A cellular deficiency of gangliosides causes hypersensitivity to Clostridium perfringens phospholipase C.
Hypersensitivity
A fixed carbohydrate:protein ratio ? 1.8 on an energy basis consumed in the context of an energy-restricted diet and reduction of body weight: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006.
Hypersensitivity
Anti-inflammatory and immunosuppressive activities of 1,3-dicyclopentyl-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylic acid diethyl ester (ZL-5015).
Hypersensitivity
Antibody- and cell-mediated immune responses of Actinobacillus pleuropneumoniae-infected and bacterin-vaccinated pigs.
Hypersensitivity
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition.
Hypersensitivity
Comparative studies on the immunosuppressive effect among 5'-deoxy-5-fluorouridine, ftorafur, and 5-fluorouracil.
Hypersensitivity
Composition and Systemic Immune Activity of the Polysaccharides from an Herbal Tea (Lycopus lucidus Turcz).
Hypersensitivity
Differential stimulation of cytosolic phospholipase A2 by bradykinin in human cystic fibrosis cell lines.
Hypersensitivity
Hypersensitivity of phospholipase C in platelets of spontaneously hypertensive rats.
Hypersensitivity
Immunomodulatory activity in vitro and in vivo of verbascose from mung beans (Phaseolus aureus).
Hypersensitivity
Immunoregulation on Mice of Low Immunity and Effects on Five Kinds of Human Cancer Cells of Panax japonicus Polysaccharide.
Hypersensitivity
Immunoregulatory effects of ethyl-acetate fraction of extracts from Tetrastigma hemsleyanum Diels et. Gilg on immune functions of ICR mice.
Hypersensitivity
Immunoregulatory function of Dictyophora echinovolvata spore polysaccharides in immunocompromised mice induced by cyclophosphamide.
Hypersensitivity
Impaired phospholipase C activity is involved in the hyperreactivity of platelets in primary hypertension.
Hypersensitivity
IN VIVO AND IN VITRO IMMUNOMODULATORY AND ANTI-INFLAMMATORY EFFECTS OF TOTAL FLAVONOIDS OF ASTRAGALUS.
Hypersensitivity
In vivo immunological activity of carboxymethylated-sulfated (1?3)-?-D-glucan from sclerotium of Poria cocos.
Hypersensitivity
Protein A induced abrogation of cyclophosphamide toxicity is associated with concomitant potentiation of immune function of host.
Hypersensitivity
Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain.
Hypersensitivity
Radioprotective effects of black seed (Nigella sativa) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats.
Hypersensitivity
Relationship between enhanced phosphoinositide turnover and cellular responses in platelets from spontaneously hypertensive rats.
Hypersensitivity
Sea cucumber (Codonopsis pilosula) oligopeptides: immunomodulatory effects based on stimulating Th cells, cytokine secretion and antibody production.
Hypersensitivity
Study on immunoregulation function of peony seed proteolysis product in mice.
Hypersensitivity
Study on the effect of regulation of Cordyceps militaris polypeptide on the immune function of mice based on a transcription factor regulatory network.
Hypersensitivity
UDP-glucose deficiency causes hypersensitivity to the cytotoxic effect of Clostridium perfringens phospholipase C.
Hypersensitivity
[Comparison of the effect of sijunzi decoction, siwu decoction and bazhen decoction on immune function in mice]
Hypersensitivity
[Effect of ethyl acetate extract of Eclipta prostrata on mice of normal and immunosupression]
Hypersensitivity
[Effects of volatile oil from Rheum palmatum on immunologic function in mice]
Hypersensitivity
[Membrane abnormalities and cellular hyperreactivity in different models of hypertension]
Hypersensitivity
[Phospholipase C hypersensitivity in hypertensive rats results from innate and acquired factors]
Hypersensitivity, Delayed
Comparative study on the anti-inflammatory and immune suppressive effect of Wilforlide A.
Hypersensitivity, Delayed
[Effect of the stem and leaf of Tripterygium wilfordii on immune function]
Hypersensitivity, Immediate
Fc epsilon R1-mediated tyrosine phosphorylation of multiple proteins, including phospholipase C gamma 1 and the receptor beta gamma 2 complex, in RBL-2H3 rat basophilic leukemia cells.
Hypertension
Alterations to the vascular vasodepressor prostaglandin system in DOCA-salt hypertensive rats and their enzymatic analysis.
Hypertension
Altered phospholipase C activity in renal medulla of DOCA-salt hypertensive rats.
Hypertension
Angiotensin II activates the beta 1 isoform of phospholipase C in vascular smooth muscle cells.
Hypertension
Antioxidant activity of propionyl-L-carnitine in liver and heart of spontaneously hypertensive rats.
Hypertension
Camrelizumab in combination with apatinib in second-line or above therapy for advanced primary liver cancer: cohort A report in a multicenter phase Ib/II trial.
Hypertension
Characterization of the high affinity [3H]nociceptin binding site in membrane preparations of rat heart: correlations with the non-opioid dynorphin binding site.
Hypertension
Crosstalk between the heme oxygenase system, aldosterone, and phospholipase C in hypertension.
Hypertension
Defining the roles of arrestin2 and arrestin3 in vasoconstrictor receptor desensitization in hypertension.
Hypertension
Dopamine-1 receptor coupling defect in renal proximal tubule cells in hypertension.
Hypertension
Effect of D3 dopamine receptor on dopamine D4 receptor expression and function in renal proximal tubule cells from Wistar-Kyoto rats and spontaneously hypertensive rats.
Hypertension
Enhanced phospholipase C activity in the vascular wall of spontaneously hypertensive rats.
Hypertension
Enhancement of phospholipase C delta 1 activity in the aortas of spontaneously hypertensive rats.
Hypertension
Escherichia coli hemolysin causes thromboxane-mediated hypertension and vascular leakage in rabbit lungs.
Hypertension
Evidence for the role of phosphatidylcholine-specific phospholipase C in sustained hypoxic pulmonary vasoconstriction.
Hypertension
Heme-arginate suppresses phospholipase C and oxidative stress in the mesenteric arterioles of mineralcorticoid-induced hypertensive rats.
Hypertension
Impaired phospholipase C activity is involved in the hyperreactivity of platelets in primary hypertension.
Hypertension
Increased expression and activity of phospholipase C in renal arterioles of young spontaneously hypertensive rats.
Hypertension
Increased responsiveness and decreased expression of G proteins in deoxycorticosterone hypertension.
Hypertension
Leukotriene and hydroxyeicosatetraenoic acid generation elicited by low doses of Escherichia coli hemolysin in rabbit lungs.
Hypertension
Perceived dietary salt intake and the risk of primary liver cancer: a population-based prospective study.
Hypertension
Phospholipase C activity is enhanced in skin fibroblasts obtained from patients with essential hypertension.
Hypertension
Phospholipase C-delta1 modulates sustained contraction of rat mesenteric small arteries in response to noradrenaline, but not endothelin-1.
Hypertension
Regulation of phospholipase C-delta1 by ARGHAP6, a GTPase-activating protein for RhoA: possible role for enhanced activity of phospholipase C in hypertension.
Hypertension
Salt-induced and spontaneous hyperactivity of phospholipase C in primary hypertension.
Hypertension
Thromboxane-mediated hypertension and vascular leakage evoked by low doses of Escherichia coli hemolysin in rabbit lungs.
Hypertension
[Increased phosphorylations of proteins involved in the expression of the physiologic response of platelets in SHR rats]
Hypertension
[Membrane abnormalities and cellular hyperreactivity in different models of hypertension]
Hypertension, Portal
Vascular contractile response and signal transduction in endothelium-denuded aorta from cirrhotic rats.
Hypertension, Pulmonary
Differential influence of arachidonic vs. eicosapentaenoic acid on experimental pulmonary hypertension.
Hypertension, Pulmonary
Lung vascular injury after administration of viable hemolysin-forming Escherichia coli in isolated rabbit lungs.
Hypertension, Pulmonary
Severe VA/Q mismatch in perfused lungs evoked by sequential challenge with endotoxin and E. coli hemolysin.
Hypertension, Pulmonary
Thromboxane-mediated hypertension and vascular leakage evoked by low doses of Escherichia coli hemolysin in rabbit lungs.
Hypertension, Pulmonary
[Hypoxic pulmonary hypertension: the role of phosphatidylcholine-specific phospholipase C]
Hypertriglyceridemia
Phospholipase C sensitive FVII activity and FVII antigen in hypertriglyceridemia.
Hyperventilation
The effect of centrally injected CDP-choline on respiratory system; involvement of phospholipase to thromboxane signaling pathway.
Hypotension
Ca++ influx is essential for the hypotensive response to arginine vasopressin-induced neuron activation of the area postrema in the rat.
Hypotension
Vibrio vulnificus hemolysin dilates rat thoracic aorta by activating guanylate cyclase.
Hypoventilation
Effects of breathing-gas pressure on pulmonary function and work capacity during immersion.
Immune System Diseases
Alzheimer's disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph.
Immune System Diseases
Investigation of Phospholipase C?1 Interaction with SLP76 Using Molecular Modeling Methods for Identifying Novel Inhibitors.
Immune System Diseases
Phospholipase C families: Common themes and versatility in physiology and pathology.
Immune System Diseases
Structural and functional integration of the PLC? interaction domains critical for regulatory mechanisms and signaling deregulation.
Infarction, Middle Cerebral Artery
CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke.
Infections
?-Hemolytic Streptococcus anginosus subsp. anginosus causes streptolysin S-dependent cytotoxicity to human cell culture lines in vitro.
Infections
A comparison of the morphologic effects of Serpulina hyodysenteriae or its beta-hemolysin on the murine cecal mucosa.
Infections
A critical role for phospholipase C in protective immunity conferred by listeriolysin O-deficient Listeria monocytogenes.
Infections
A nested case-control study on association between hepatitis C virus antibodies and primary liver cancer in a cohort of 9,775 men in Taiwan.
Infections
A species-specific nucleotide sequence of Mycobacterium tuberculosis encodes a protein that exhibits hemolytic activity when expressed in Escherichia coli.
Infections
A specific gene expression program triggered by Gram-positive bacteria in the cytosol.
Infections
Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes.
Infections
Activation of host phospholipases C and D in macrophages after infection with Listeria monocytogenes.
Infections
Acute hemorrhagic necrotizing enteritis: a case report and review of the literature.
Infections
Adherence to the Chinese or American Dietary Guidelines is Associated with a Lower Risk of Primary Liver Cancer in China: A Case-Control Study.
Infections
Aeromonas hydrophila-associated septicemia in captive crocodiles (Crocodylus johnstoni and Crocodylus porosus).
Infections
Aflatoxin is not a probably human carcinogen: the published evidence is sufficient.
Infections
Alpha-hemolysin contributes to the pathogenicity of piliated digalactoside-binding Escherichia coli in the kidney: efficacy of an alpha-hemolysin vaccine in preventing renal injury in the BALB/c mouse model of pyelonephritis.
Infections
An in vitro cell-culture model demonstrates internalin- and hemolysin-independent translocation of Listeria monocytogenes across M cells.
Infections
Analysis of hydrolytic products from choline-labeled host cell phospholipids during growth of Rickettsia prowazekii.
Infections
Analysis of the infectious entry pathway of human papillomavirus type 33 pseudovirions.
Infections
Antibodies Against Hemolysin and Cytotoxic Necrotizing Type 1 (CNF1) Reduce Bladder Inflammation in a Mouse Model of Urinary Tract Infection with Toxigenic Uropathogenic Escherichia coli.
Infections
Antibody response to alpha- and betahemolysin from Staphylococcus aureus in patients with staphylococcal infections and in normals.
Infections
Association of hemolysin production, hemagglutination of human erythrocytes, and virulence for chicken embryos of extraintestinal Escherichia coli isolates.
Infections
Binding to and killing of human renal epithelial cells by hemolytic P-fimbriated E. coli.
Infections
Biofilm formation in uropathogenic Escherichia coli strains: relationship with prostatitis, urovirulence factors and antimicrobial resistance.
Infections
Biological and genetic characteristics of uropathogenic Escherichia coli strains.
Infections
Bis-molybdopterin guanine dinucleotide modulates hemolysin expression under anaerobiosis and contributes to fitness in vivo in uropathogenic Escherichia coli.
Infections
Blocking phosphatidylcholine utilization in Pseudomonas aeruginosa, via mutagenesis of fatty acid, glycerol and choline degradation pathways, confirms the importance of this nutrient source in vivo.
Infections
Bovine colostrum ameliorates diarrhea in infection with diarrheagenic Escherichia coli, shiga toxin-producing E. Coli, and E. coli expressing intimin and hemolysin.
Infections
Characteristics of potential lymphoma-inducing cells in mice sensitive or resistant to lymphomagenesis by radiation leukemia virus variants.
Infections
Characterization of Clostridium perfringens TpeL toxin gene carriage, production, cytotoxic contributions, and trypsin sensitivity.
Infections
Characterization of gastrin-releasing peptide receptor expressed in Sf9 insect cells by baculovirus.
Infections
Characterization of the groESL operon in Listeria monocytogenes: utilization of two reporter systems (gfp and hly) for evaluating in vivo expression.
Infections
Classification of pathogenic Escherichia coli according to serotype and the production of virulence factors, with special reference to colonization-factor antigens.
Infections
Clinical isolates of Aeromonas veronii biovar veronii harbor a nonfunctional gene similar to the thermostable direct hemolysin-related hemolysin (trh) gene of Vibrio parahaemolyticus.
Infections
Cloned hemolysin genes from Escherichia coli that cause urinary tract infection determine different levels of toxicity in mice.
Infections
Cloning, sequencing, and role in virulence of two phospholipases (A1 and C) from mesophilic Aeromonas sp. serogroup O:34.
Infections
Clostridium perfringens in poultry: an emerging threat for animal and public health.
Infections
Clostridium perfringens phospholipase C impairs innate immune response by inducing integrated stress response and mitochondrial-induced epigenetic modifications.
Infections
Comparative Analysis of the Flavobacterium columnare Genomovar I and II Genomes.
Infections
Comparative pathogenicity of Escherichia coli O157 and intimin-negative non-O157 Shiga toxin-producing E coli strains in neonatal pigs.
Infections
Comparative study for the presence of enterococcal virulence factors gelatinase, hemolysin and biofilm among clinical and commensal isolates of enterococcus faecalis.
Infections
Compartmentalization of the broad-range phospholipase C activity to the spreading vacuole is critical for Listeria monocytogenes virulence.
Infections
Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes.
Infections
Complex Multilevel Control of Hemolysin Production by Uropathogenic Escherichia coli.
Infections
Conjugated linoleic acid-induced apoptosis in mouse mammary tumor cells is mediated by both G protein coupled receptor-dependent activation of the AMP-activated protein kinase pathway and by oxidative stress.
Infections
Construction of a flagellum-negative mutant of Proteus mirabilis: effect on internalization by human renal epithelial cells and virulence in a mouse model of ascending urinary tract infection.
Infections
CtaA of Staphylococcus aureus is required for starvation survival, recovery, and cytochrome biosynthesis.
Infections
Cytotoxic necrotizing factor production by hemolytic strains of Escherichia coli causing extraintestinal infections.
Infections
Development of ELISAs for diagnosis of acute typhoid fever in Nigerian children.
Infections
Differences in antibodies to the surface components of mumps virus after immunization with formalin-inactivated and live vaccines.
Infections
Different heparan sulfate proteoglycans serve as cellular receptors for human papillomaviruses.
Infections
Differential function of Listeria monocytogenes listeriolysin O and phospholipases C in vacuolar dissolution following cell-to-cell spread.
Infections
Discontinuing cotrimoxazole preventive therapy in HIV-infected adults who are stable on antiretroviral treatment in Uganda (COSTOP): A randomised placebo controlled trial.
Infections
E. coli hemolysin-induced lipid mediator metabolism in alveolar macrophages: impact of eicosapentaenoic acid.
Infections
Efficient Colonization and Therapy of Human Hepatocellular Carcinoma (HCC) Using the Oncolytic Vaccinia Virus Strain GLV-1h68.
Infections
Endotoxin "priming" potentiates lung vascular abnormalities in response to Escherichia coli hemolysin: an example of synergism between endo- and exotoxin.
Infections
Enterohemolysin operon of Shiga toxin-producing Escherichia coli: a virulence function of inflammatory cytokine production from human monocytes.
Infections
Enzyme-linked immunosorbent assay for detection of antibodies to Pseudomonas aeruginosa exoproteins.
Infections
Escherichia vulneris: an unusual cause of complicated diarrhoea and sepsis in an infant. A case report and review of literature.
Infections
Evaluation of an isogenic hemolysin-deficient mutant in the human model of Haemophilus ducreyi infection.
Infections
Evaluation of pig lungs following an experimental challenge with Actinobacillus pleuropneumoniae serotype 1 and 5 in pigs inoculated with either hemolysin protein and/or outer membrane proteins.
Infections
Evidence for selective coupling of alpha 1-adrenergic receptors to phospholipase C-beta 1 in rat neonatal cardiomyocytes.
Infections
Evidence for the cytotoxic effects of Mycobacterium tuberculosis phospholipase C towards macrophages.
Infections
Expanding the Liver Imaging Reporting and Data System (LI-RADS) v2018 diagnostic population: performance and reliability of LI-RADS for distinguishing hepatocellular carcinoma (HCC) from non-HCC primary liver carcinoma in patients who do not meet strict LI-RADS high-risk criteria.
Infections
Functional characterization of the phospholipase C activity of Rv3487c and its localization on the cell wall of Mycobacterium tuberculosis.
Infections
Functional redundancy of Burkholderia pseudomallei phospholipase C enzymes and their role in virulence.
Infections
Gene block encoding production of cytotoxic necrotizing factor 1 and hemolysin in Escherichia coli isolates from extraintestinal infections.
Infections
Gene clusters governing the production of hemolysin and mannose-resistant hemagglutination are closely linked in Escherichia coli serotype O4 and O6 isolates from urinary tract infections.
Infections
Genetic characterization of clinical and environmental Vibrio parahaemolyticus from the Northeast USA reveals emerging resident and non-indigenous pathogen lineages.
Infections
Genogrouping and incidence of virulence factors of Enterococcus faecalis in liver transplant patients differ from blood culture and fecal isolates.
Infections
Genome-Wide Analysis of Oceanimonas sp. GK1 Isolated from Gavkhouni Wetland (Iran) Demonstrates Presence of Genes for Virulence and Pathogenicity.
Infections
Hemagglutinin, hemolysin, and bactericidin response of dogs with bladder pouch infection.
Infections
Hemolysin and K Antigens in Relation to Serotype and Hemagglutination Type of Isolated from Extraintestinal Infections.
Infections
Hemolysin and K antigens in relation to serotype and hemagglutination type of Escherichia coli isolated from extraintestinal infections.
Infections
Hemolysin and the multifunctional autoprocessing RTX toxin are virulence factors during intestinal infection of mice with Vibrio cholerae El Tor O1 strains.
Infections
Hemolysin as a virulence factor for systemic infection with isolates of Mycobacterium avium complex.
Infections
Hemolysin production as a virulence marker in symptomatic and asymptomatic urinary tract infections caused by Escherichia coli.
Infections
Hemolysin-producing Listeria monocytogenes affects the immune response to T-cell-dependent and T-cell-independent antigens.
Infections
Hemolysis due to Alpha-Hemolytic Enterococcus Urinary Infection: A Rare Cause of Early and Severe Unconjugated Hyperbilirubinemia in a Neonate.
Infections
Hemolytic Escherichia coli strains in the human fecal flora as potential urinary pathogens.
Infections
Hemolytic Phospholipase C Inhibition Protects Lung Function during Pseudomonas aeruginosa Infection.
Infections
Hemolytically active (acylated) alpha-hemolysin elicits interleukin-1beta (IL-1beta) but augments the lethality of Escherichia coli by an IL-1- and tumor necrosis factor-independent mechanism.
Infections
Hepatitis B virus and primary liver cancer on Chongming Island, People's Republic of China.
Infections
Hepatitis B virus and primary liver cell carcinoma. The application of molecular biology.
Infections
Hepatitis C Virus Infection and the Temporal Trends in the Risk of Liver Cancer: A National Register-Based Cohort Study in Sweden.
Infections
Hepatocellular carcinoma and other primary liver cancers in hepatitis C patients in Sweden - a low endemic country.
Infections
High incidence of hemolysin production by Enterococcus (Streptococcus) faecalis strains associated with human parenteral infections.
Infections
Human cytomegalovirus disrupts the major histocompatibility complex class I Peptide-loading complex and inhibits tapasin gene transcription.
Infections
Identification and Characterization of Clostridium perfringens Beta Toxin Variants with Differing Trypsin Sensitivity and in vitro Cytotoxicity Activity.
Infections
Identification of novel potential virulence-associated factors in Haemophilus parasuis.
Infections
Identification of virulence genes in uropathogenic Escherichia coli by multiplex polymerase chain reaction and their association with infectivity in mice.
Infections
Immunization of rabbits with recombinant Clostridium perfringens alpha toxins CPA-C and CTB-CPA-C in a bicistronic design expression system confers strong protection against challenge.
Infections
Immunization with a nontoxic naturally occurring Clostridium perfringens alpha toxin induces neutralizing antibodies in rabbits.
Infections
Immunization with temperature-sensitive mutants of Actinobacillus pleuropneumoniae induces protective hemolysin-neutralizing antibodies in mice.
Infections
Impact of arachidonic versus eicosapentaenoic acid on exotonin-induced lung vascular leakage: relation to 4-series versus 5-series leukotriene generation.
Infections
In situ expression patterns of melanoma inhibitory activity 2 in healthy and diseased livers.
Infections
Incidence of hemolysin, gelatinase, and aggregation substance among enterococci isolated from patients with endocarditis and other infections and from feces of hospitalized and community-based persons.
Infections
Incidence of Intraoperative and Postoperative Complications After Posterolateral Corner Reconstruction or Repair: A Systematic Review of the Current Literature.
Infections
Individuals having variant genotypes of cytochrome P450 2C19 are at increased risk of developing primary liver cancer in Han populations, without infection with the hepatitis virus.
Infections
Induction of apoptosis in Caco-2 and HT-29 human intestinal epithelial cells by enterohemolysin produced by classic enteropathogenic Escherichia coli.
Infections
Infection and cellular defense dynamics in a novel 17?-estradiol murine model of chronic human group B streptococcus genital tract colonization reveal a role for hemolysin in persistence and neutrophil accumulation.
Infections
Inflammatory lipid mediator generation elicited by viable hemolysin-forming Escherichia coli in lung vasculature.
Infections
Influence of cloned Escherichia coli hemolysin genes, S-fimbriae and serum resistance on pathogenicity in different animal models.
Infections
Inhibition of agonist-induced activation of phospholipase C following poxvirus infection.
Infections
Inhibition of listeriolysin O and phosphatidylcholine-specific production in Listeria monocytogenes by subinhibitory concentrations of plant essential oils.
Infections
Invasive Escherichia coli infections in children: bacterial characteristics in different age groups and clinical entities.
Infections
Isolation of enterotoxigenic, hemolytic, and antibiotic-resistant Aeromonas hydrophila strains from infected fish in Bangladesh.
Infections
Japanese Encephalitis Virus Exploits Dopamine D2 Receptor-phospholipase C to Target Dopaminergic Human Neuronal Cells.
Infections
K-antigen identification, hemolysin production, and hemagglutination types of Escherichia coli O6 strains isolated from patients with urinary tract infections.
Infections
Lack of association between hemolysin production and acute inflammation in human urinary tract infection.
Infections
Leukotriene and hydroxyeicosatetraenoic acid generation elicited by low doses of Escherichia coli hemolysin in rabbit lungs.
Infections
Leukotriene-mediated coronary vasoconstriction and loss of myocardial contractility evoked by low doses of Escherichia coli hemolysin in perfused rat hearts.
Infections
Levels of Hemolysin Are Not Directly Proportional to Virulence in Experimental Infections of Mice.
Infections
Levels of Listeria monocytogenes hemolysin are not directly proportional to virulence in experimental infections of mice.
Infections
Listeria monocytogenes evades killing by autophagy during colonization of host cells.
Infections
Listeria monocytogenes phospholipase C-dependent calcium signaling modulates bacterial entry into J774 macrophage-like cells.
Infections
Liver Cancer in Viet Nam: Risk Estimates of Viral Infections and Dioxin Exposure in the South and North Populations.
Infections
Miltefosine Reduces the Cytolytic Activity and Virulence of Acinetobacter baumannii.
Infections
Minor role of hepatitis B and C virus infection in the etiology of hepatocellular carcinoma in a low-endemic area.
Infections
Modification of phospholipase C and phospholipase A2 activities during poliovirus infection.
Infections
Modulation of enzymatic activity and biological function of Listeria monocytogenes broad-range phospholipase C by amino acid substitutions and by replacement with the Bacillus cereus ortholog.
Infections
Molecular cloning and physical characterization of a chromosomal hemolysin from Escherichia coli.
Infections
Molecular epidemiology of adhesin and hemolysin virulence factors among uropathogenic Escherichia coli.
Infections
Molecular interaction between methicillin-resistant Staphylococcus aureus (MRSA) and chicken breast reveals enhancement of pathogenesis and toxicity for food-borne outbreak.
Infections
Most human isolates of Mycobacterium avium Mav-A and Mav-B are strong producers of hemolysin, a putative virulence factor.
Infections
Mycoplasma pneumoniae infection complicated by paroxysmal cold hemoglobinuria with anti-P specificity of biphasic hemolysin.
Infections
Nitric oxide biosynthesis in an exotoxin-induced septic lung model: role of cNOS and impact on pulmonary hemodynamics.
Infections
Notes from the Field: Mycobacterium chimaera Contamination of Heater-Cooler Devices Used in Cardiac Surgery - United States.
Infections
Occurrence of cirrhosis and primary liver cancer in an Eskimo population hyperendemically infected with hepatitis B virus.
Infections
Occurrence of genes for P and S fimbriae and hemolysin in urinary Escherichia coli.
Infections
Osmoprotectants and phosphate regulate expression of phospholipase C in Pseudomonas aeruginosa.
Infections
Parallel evolution of two clades of a major Atlantic endemic Vibrio parahaemolyticus pathogen lineage by independent acquisition of related pathogenicity islands.
Infections
Pathogenesis of Proteus mirabilis in Catheter-Associated Urinary Tract Infections.
Infections
Pertussis toxin and extracytoplasmic adenylate cyclase as virulence factors of Bordetella pertussis.
Infections
pH-regulated activation and release of a bacteria-associated phospholipase C during intracellular infection by Listeria monocytogenes.
Infections
Phenotypic comparison of Pseudomonas aeruginosa strains isolated from a variety of clinical sites.
Infections
Phosphatidylcholine-specific phospholipase C but not gamma interferon regulate gene expression and secretion of CC Chemokine Ligand-2 (CCL-2) by human astrocytes during infection by Toxoplasma gondii.
Infections
Phosphoinositides differentially regulate bacterial uptake and Nramp1-induced resistance to Legionella infection in Dictyostelium.
Infections
Phospholipase C activity in microorganisms associated with reproductive tract infection.
Infections
Phospholipase C From Alternaria alternata Is Induced by Physiochemical Cues on the Pear Fruit Surface That Dictate Infection Structure Differentiation and Pathogenicity.
Infections
Phospholipase C signaling is involved in porcine reproductive and respiratory syndrome virus infection in cell cultures.
Infections
Phospholipase gene expression during Paracoccidioides brasiliensis morphological transition and infection.
Infections
Phylogenomic analysis of a highly virulent Escherichia coli ST83 lineage with potential animal-human transmission.
Infections
Placental and intestinal alkaline phosphatases are receptors for Aeromonas sobria hemolysin.
Infections
Presentation of Listeria monocytogenes to CD8+ T cells requires secretion of hemolysin and intracellular bacterial growth.
Infections
Prevalence of pandemic thermostable direct hemolysin-producing Vibrio parahaemolyticus O3:K6 in seafood and the coastal environment in Japan.
Infections
Primary liver cancer in a high-incidence area in north Italy: etiological hypotheses arising from routinely collected data.
Infections
Production of enterotoxin, verotoxin, hemolysin and cytotoxic necrotizing factor by Escherichia coli of intestinal and extraintestinal origin.
Infections
Production of extracellular virulence factors by Pseudomonas aeruginosa isolates obtained from tracheal, urinary tract, and wound infections.
Infections
Protective efficacy of a novel alpha hemolysin subunit vaccine (AT62) against Staphylococcus aureus skin and soft tissue infections.
Infections
Protein kinase C isozymes regulate matrix metalloproteinase-1 expression and cell invasion in Helicobacter pylori infection.
Infections
Proteolytic pathways of activation and degradation of a bacterial phospholipase C during intracellular infection by Listeria monocytogenes.
Infections
Pseudomonas aeruginosa from patients with cystic fibrosis affects function of pulmonary surfactant.
Infections
Purification of the thermostable direct hemolysin of Vibrio parahaemolyticus by immunoaffinity column chromatography.
Infections
Putative virulence genes in Moritella viscosa: Activity during invitro inoculation and invivo infection.
Infections
Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer.
Infections
Quantification of bacteriuria caused by Hemolysin-positive Escherichia coli in human and mouse urine using quantitative polymerase chain reaction (qPCR) targeting hlyD.
Infections
Quercetin inhibits swarming motility and activates biofilm production of Proteus mirabilis possibly by interacting with central regulators, metabolic status or active pump proteins.
Infections
Randomly amplified polymorphic DNA analysis of clinical and environmental isolates of Vibrio vulnificus and other vibrio species.
Infections
Reduction of HSV-1 binding to BHK cells after treatment with phosphatidylinositol-specific phospholipase C.
Infections
Requirement of the Listeria monocytogenes broad-range phospholipase PC-PLC during infection of human epithelial cells.
Infections
Role of a type 6 secretion system effector Hcp of Aeromonas hydrophila in modulating activation of host immune cells.
Infections
Role of Antibodies in Protection Elicited by Active Vaccination with Genetically Inactivated Alpha Hemolysin in a Mouse Model of Staphyloccocus aureus Skin and Soft Tissue Infections.
Infections
Role of bacterial hemolysin production in induction of macrophage Ia expression during infection with Listeria monocytogenes.
Infections
Role of haemolytic and non-haemolytic phospholipase C from Pseudomonas aeruginosa in interleukin-8 release from human monocytes.
Infections
Role of hemolysin BL in the pathogenesis of extraintestinal Bacillus cereus infection assessed in an endophthalmitis model.
Infections
Screening and sequence analysis of the hemolysin gene of Fusobacterium necrophorum.
Infections
SEROLOGIC RESPONSE TO STREPTOCOCCAL HEMOLYSIN AND HYALURONIDASE IN STREPTOCOCCAL AND RHEUMATIC INFECTION.
Infections
Serotype, hemolysin production, and adherence characteristics of strains of Escherichia coli causing urinary tract infection in dogs.
Infections
Serotypes, hemolysin production, and receptor recognition of Escherichia coli strains associated with neonatal sepsis and meningitis.
Infections
Serum antibody response to Pseudomonas aeruginosa antigens during corneal infection.
Infections
Serum resistance among Escherichia coli strains causing urinary tract infection in relation to O type and the carriage of hemolysin, colicin, and antibiotic resistance determinants.
Infections
Severe VA/Q mismatch in perfused lungs evoked by sequential challenge with endotoxin and E. coli hemolysin.
Infections
Simple purification method for a Vibrio vulnificus hemolysin by a hydrophobic column chromatography in the presence of a detergent.
Infections
Stimulus-response coupling in monocytes infected with Leishmania. Attenuation of calcium transients is related to defective agonist-induced accumulation of inositol phosphates.
Infections
STUDIES ON THE PATHOGENESIS OF STAPHYLOCOCCAL INFECTION : III. THE EFFECT OF TISSUE NECROSIS AND ANTITOXIC IMMUNITY.
Infections
Study of biological characteristics of Pseudomonas aeruginosa strains isolated from patients with cystic fibrosis and from patients with extra-pulmonary infections.
Infections
Study of the chemical nature of Frp/3 cell recognition units for hepatitis A virus.
Infections
Successful small intestine colonization of adult mice by Vibrio cholerae requires ketamine anesthesia and accessory toxins.
Infections
Sulfur Assimilation Alters Flagellar Function and Modulates the Gene Expression Landscape of Serratia marcescens.
Infections
Swine antibody-dependent cellular cytotoxicity against pseudorabies virus-infected cells.
Infections
The evaluation of an immunoperoxidase assay applicable in antiviral drug screening.
Infections
The Extracellular Domain of the ?2 Integrin ? Subunit (CD18) Is Sufficient for Escherichia coli Hemolysin and Aggregatibacter actinomycetemcomitans Leukotoxin Cytotoxic Activity.
Infections
The Forgotten Virulence Factor: The 'non-conventional' Hemolysin TlyA And Its Role in Helicobacter pylori Infection.
Infections
The hemolytic and cytolytic activity of group B streptococcal hemolysin and its possible role in early onset group B streptococcal disease.
Infections
The Impact of the Staphylococcus aureus Virulome on Infection in a Developing Country: A Cohort Study.
Infections
The Legionella pneumophila Dot/Icm-secreted effector PlcC/CegC1 together with PlcA and PlcB promotes virulence and belongs to a novel zinc metallophospholipase C family present in bacteria and fungi.
Infections
The Legionella pneumophila tatB gene facilitates secretion of phospholipase C, growth under iron-limiting conditions, and intracellular infection.
Infections
The luteinizing hormone receptor activates phospholipase C via preferential coupling to Gi2.
Infections
The role of diabetes in hepatocellular carcinoma: a case-control study among United States Veterans.
Infections
The Salmonella Typhi hlyE gene plays a role in invasion of cultured epithelial cells and its functional transfer to S. Typhimurium promotes deep organ infection in mice.
Infections
The significance of leptospiral hemolysin in the pathogenesis of Leptospira pomona infections.
Infections
The two distinct phospholipases C of Listeria monocytogenes have overlapping roles in escape from a vacuole and cell-to-cell spread.
Infections
Thromboxane-mediated hypertension and vascular leakage evoked by low doses of Escherichia coli hemolysin in rabbit lungs.
Infections
Transcriptome Differences in Porcine Alveolar Macrophages from Tongcheng and Large White Pigs in Response to Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection.
Infections
Trypanosoma cruzi: infection of cultured human endothelial cells alters inositol phosphate synthesis.
Infections
Two distinct phospholipases C of Listeria monocytogenes induce ceramide generation, nuclear factor-kappa B activation, and E-selectin expression in human endothelial cells.
Infections
Urease-positive, Kanagawa-negative Vibrio parahaemolyticus from patients and the environment in the Pacific Northwest.
Infections
Urovirulence determinants in Escherichia coli isolates causing first-episode and recurrent cystitis in women.
Infections
US28 is a potent activator of phospholipase C during HCMV infection of clinically relevant target cells.
Infections
Varicella zoster virus as a possible trigger for the development of pityriasis lichenoides et varioliformis acuta: retrospective analysis of our institutional cases.
Infections
Vibrio cholerae hemolysin is required for lethality, developmental delay, and intestinal vacuolation in Caenorhabditis elegans.
Infections
Virulence characteristics of Escherichia coli in relation to host response in men with symptomatic urinary tract infection.
Infections
Virulence determinants of Escherichia coli O6 extraintestinal isolates analysed by Southern hybridizations and DNA long range mapping techniques.
Infections
Virulence determinants of uropathogenic Escherichia coli in fecal strains from intestinal infections and healthy individuals.
Infections
Virulence factors of uropathogenic Escherichia coli from a university hospital in Ribeirão Preto, São Paulo, Brazil.
Infections
Virulence genes and P fimbriae PapA subunit diversity in canine and feline uropathogenic Escherichia coli.
Infections
Virulence-associated characteristics of Escherichia coli in urinary tract infection: a statistical analysis with special attention to type 1C fimbriation.
Infections
[A case-control study on relationship between hepatitis C infection and primary liver cancer]
Infections
[A study of the relationship between the occurrence of P-fimbriae and hemolysin production in Escherichia coli causing extraintestinal infections and the infectious site]
Infections
[A study on primary liver cancer in tree shrews induced by human hepatitis B virus and aflatoxin B1]
Infections
[An epidemiologic study on the aetiological factors of primary liver cancer in Shunde City of Guangdong province]
Infections
[Antibody titers against the thermostable direct hemolysin in the sera of patients with Vibrio parahaemolyticus infection]
Infections
[Association between Helicobacter infection in liver tissue and primary liver carcinoma]
Infections
[Distribution of Cl. perfringens in preserved food and the lecithinase activity of isolated strains]
Infections
[Experimental urinary tract infection caused by Escherichia coli in diabetic mouse--uroepithelial colonization and polymorphonuclear leukocyte function]
Infections
[Frequency of colicin and hemolysins in Escherichia coli isolated from pregnant patients with urinary tract infection, symptomatic and asymptomatic]
Infections
[Hepatitis B virus infection and aflatoxin exposure in the development of primary liver cancer]
Infections
[Longitudinal study of aflatoxin exposure in the development of primary liver cancer in patients with chronic hepatitis].
Infections
[Multiple pathogenic factors analysis on primary liver cancer the role of HBV infection combined with other risk factors in the occurrence of PLC]
Infections
[Pilus type, hemagglutination titer and hemolysin production of Escherichia coli isolated from urogenital infections]
Infections
[Serodiagnosis of Pseudomonas aeruginosa infections in mucoviscidosis: comparative study of Western blotting, ELISA exotoxin A and ELISA phospholipase C]
Infections
[Staphylococcal hemolysins and autovaccine applications in staphylococcal infections]
Infections
[Studies on the virulent factor of Escherichia coli isolated from urogenital infection--pilus type and adherence to human exfoliated uroepithelial cells etc]
Infections
[The enterotoxigenic capacity of hemolysin-producing strains of Proteus isolated in acute intestinal infections in children]
Infectious Mononucleosis
Absorbed heterophile and ox-cell hemolysin test in serodiagnosis of infectious mononucleosis.
Infectious Mononucleosis
Agglutination in rheumatoid arthritis serum of sheep cells sensitized with hemolysin and infectious mononucleosis agglutinins.
Infectious Mononucleosis
Evaluation of tests for infectious mononucleosis through proficiency testing.
Infectious Mononucleosis
The ox cell hemolysin test as a diagnostic procedure in infectious mononucleosis.
Infectious Mononucleosis
[HEMOLYSIN TESTS WITH CATTLE ERYTHROCYTES IN THE DIAGNOSIS OF INFECTIOUS MONONUCLEOSIS.]
Infectious Mononucleosis
[Significance of the hemolysin test in the diagnosis of infectious mononucleosis in children]
Infectious Mononucleosis
[The hemolysin test in the laboratory diagnosis of infectious mononucleosis]
Infertility
Phospholipase C?2 Is Required for Luminal Expansion of the Epididymal Duct during Postnatal Development in Mice.
Infertility, Male
A maternally inherited autosomal point mutation in human phospholipase C zeta (PLC?) leads to male infertility.
Infertility, Male
A novel ENU-induced mutation in Phospholipase C gamma 2 causes inflammatory arthritis, metabolic defects, and in vitro male infertility in the mouse.
Infertility, Male
Starting a new life: sperm PLC-zeta mobilizes the Ca2+ signal that induces egg activation and embryo development: an essential phospholipase C with implications for male infertility.
Inflammatory Bowel Diseases
GSK-1605786, a selective small-molecule antagonist of the CCR9 chemokine receptor for the treatment of Crohn's disease.
Influenza, Human
A Ca(2+)-dependent signalling circuit regulates influenza A virus internalization and infection.
Influenza, Human
Asymmetry of influenza virus membrane bilayer demonstrated with phospholipase C.
Influenza, Human
High-throughput genotyping assays for identification of glycophorin B deletion variants in population studies.
Influenza, Human
Human neutrophil stimulation by influenza virus: relationship of cytoplasmic pH changes to cell activation.
Influenza, Human
Influenza virus inhibits amiloride-sensitive Na+ channels in respiratory epithelia.
Influenza, Human
Structures associated with influenza virus suspensions treated with phospholipase C.
Influenza, Human
TAP-dependent major histocompatibility complex class I presentation of soluble proteins using listeriolysin.
Influenza, Human
The effect of phospholipase C on influenza viruses: limited release of "soluble" V-antigens and of neuraminidase.
Influenza, Human
Ultrastructure and some biological properties of influenza A virus. III. The role of influenza A virus lipids in interferon induction.
Insulin Resistance
Hepatic insulin resistance in KKA(y) mice and its amelioration by pioglitazone do not involve alterations in phospholipase C activity.
Insulin Resistance
Oral supplementation of propionyl-l-carnitine reduces body weight and hyperinsulinaemia in obese Zucker rats.
Insulin Resistance
Pharmacological effects and clinical applications of propionyl-L-carnitine.
Insulin Resistance
The effects of phospholipase C inhibition on insulin-stimulated glucose transport in skeletal muscle.
Insulin Resistance
The Phospholipase C Inhibitor U73122 Attenuates trans-10, cis-12 Conjugated Linoleic Acid-Mediated Inflammatory Signaling and Insulin Resistance in Human Adipocytes.
Insulinoma
Arginine vasopressin-stimulated insulin secretion and elevation of intracellular Ca++ concentration in rat insulinoma cells: influences of a phospholipase C inhibitor 1-[6-[[17 beta-methoxyestra-1,3,5(10)-trien- 17-yl]amino]hexyl]-1H-pyrrole-2,5-dione (U-73122) and a phospholipase A2 inhibitor N-(p-amylcinnamoyl)anthranilic acid.
Insulinoma
C-peptide, insulin and proinsulinlike components in diabetic and nondiabetic human pancreas.
Insulinoma
Effects of secretagogues on insulin biosynthesis and secretion in polyamine-depleted pancreatic beta-cells.
Insulinoma
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
Insulinoma
Overexpression of G11alpha and isoforms of phospholipase C in islet beta-cells reveals a lack of correlation between inositol phosphate accumulation and insulin secretion.
Intermittent Claudication
Effect of Propionylcarnitine on Changes in Endothelial Function and Plasma Levels of Adhesion Molecules Induced by Acute Exercise in Patients with Intermittent Claudication.
Intestinal Diseases
Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease.
Intestinal Neoplasms
Spontaneous and iatrogenic spreading of liver-derived cells into peripheral blood of patients with primary liver cancer.
Intestinal Neoplasms
[Clinical implications of spontaneous and iatrogenic dissemination of tumor cells in patients with primary liver cancer]
Intestinal Obstruction
Lecithinase and hyaluronidase in experimental intestinal obstruction.
Intestinal Obstruction
[Warning signals in acute abdominal disorders. Lactate is the best marker of mesenteric ischemia]
Intracranial Aneurysm
Novel evidence of PLC delta2 involvement in the regulation of the differential evolution of human aneurysms.
Intracranial Thrombosis
[Cerebral thrombosis and platelet aggregation caused by phospholipase C]
Iron Deficiencies
[Hemolytic activity and toxigenicity of Vibrio cholerae of different serogroups]
Irritable Bowel Syndrome
From psychology to physicality: how nerve growth factor transduces early life stress into gastrointestinal motility disorders later in life.
Ischemic Attack, Transient
Pathological laughter as prodromal manifestation of transient ischemic attacks--case report and brief review.
Ischemic Stroke
Implantable cardiac monitors to detect atrial fibrillation after cryptogenic stroke: a systematic review and economic evaluation.
Joint Instability
A case report of anterior cruciate ligament and posterolateral corner reconstruction using tendon graft preserved in situ.
Keratoconjunctivitis
Adhesion and invasion of a mutant Shigella flexneri to an eukaryotic cell line in absence of the 220-kb virulence plasmid.
Kidney Failure, Chronic
Propionyl-L-carnitine therapy: effects on endothelin-1 and homocysteine levels in patients with peripheral arterial disease and end-stage renal disease.
Knee Dislocation
Knee dislocations: is reconstruction of the posterior cruciate ligament crucial?
Knee Dislocation
Posterolateral Corner Repair With Internal Bracing and Peroneal Nerve Neurolysis.
Kyphosis
MRI study of post-traumatic incompetence of posterior ligamentous complex: importance of the supraspinous ligament. Prospective study of 74 traumatic fractures.
Kyphosis
Prediction of posterior ligamentous complex injury in thoracolumbar fractures using non-MRI imaging techniques.
Lambert-Eaton Myasthenic Syndrome
[Recent advance in research for myasthenia gravis, in relation to various antibodies affecting synaptic structure and function]
Laryngomalacia
Clinical aspects of type 1 posterior laryngeal clefts: literature review and a report of 31 patients.
Leiomyoma
Expression of endothelin receptors in human myometrium during pregnancy and in uterine leiomyomas.
Leprosy
The in situ characteristics of mononuclear cell infiltrates in dermal lesions of leprosy.
Leptospirosis
[THE SIGNIFICANCE OF HEMOLYSIN AND LIPASE IN THE PATHOGENESIS OF LEPTOSPIROSIS.]
Leukemia
Analysis of a Ca2+-activated K+ channel that mediates hyperpolarization via the thrombin receptor pathway.
Leukemia
ATP-dependent activation of phospholipase C by antigen, NECA, Na3VO4, and GTP-gamma-S in permeabilized RBL cell ghosts: differential augmentation by ATP, phosphoenolpyruvate and phosphocreatine.
Leukemia
Ceramide inhibits IgE-mediated activation of phospholipase D, but not of phospholipase C, in rat basophilic leukemia (RBL-2H3) cells.
Leukemia
Chronic Li+ attenuates agonist- and phorbol ester-mediated Na+/H+ antiporter activity in HL-60 cells.
Leukemia
Combination chemotherapy with Clostridium perfringens phospholipase C and cytosine antimetabolites: complementary inhibition directed at membrane lipids.
Leukemia
Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes.
Leukemia
Detection of neutral active phosphatidylcholine-specific phospholipase C in Friend leukemia cells before and after erythroid differentiation.
Leukemia
Dexamethasone up-regulates A3 adenosine receptors in rat basophilic leukemia (RBL-2H3) cells.
Leukemia
Docosahexaenoic acid induces increases in [Ca2+]i via inositol 1,4,5-triphosphate production and activates protein kinase C gamma and -delta via phosphatidylserine binding site: implication in apoptosis in U937 cells.
Leukemia
Effect of 7,12-Dimethylbenz[a]anthracene on Phagocytosis and Antibody Formation in Friend Virus Leukemia.
Leukemia
Enhanced AKR leukemogenesis by the dual tropic viruses. I. The time and site of origin of potential leukemic cells.
Leukemia
Fc epsilon R1-mediated tyrosine phosphorylation of multiple proteins, including phospholipase C gamma 1 and the receptor beta gamma 2 complex, in RBL-2H3 rat basophilic leukemia cells.
Leukemia
Fc epsilon RI-ligation induces association of tyrosine phosphorylated proteins with Src homology 2 domains of phospholipase C gamma 1 in RBL-2H3 rat basophilic leukemia cells.
Leukemia
Hexadecylphosphocholine inhibits phosphatidylinositol and phosphatidylcholine phospholipase C in human leukemia cells.
Leukemia
IgE-induced tyrosine phosphorylation of phospholipase C-gamma 1 in rat basophilic leukemia cells.
Leukemia
Immunosuppression by leukemia viruses. I. Effect of Friend disease virus on cellular and humoral hemolysin responses of mice to a primary immunization with sheep erythrocytes.
Leukemia
Interaction of CD4:lck with the T cell receptor/CD3 complex induces early signaling events in the absence of CD45 tyrosine phosphatase.
Leukemia
Involvement of pertussis toxin-sensitive GTP-binding proteins in sphingosine 1-phosphate-induced activation of phospholipase C-Ca2+ system in HL60 leukemia cells.
Leukemia
Nuclear phospholipase C gamma: punctate distribution and association with the promyelocytic leukemia protein.
Leukemia
Orthovanadate induces translocation of phospholipase C-gamma 1 and -gamma 2 in permeabilized mast cells.
Leukemia
Pertussis toxin inhibits phospholipase C activation and Ca2+ mobilization by sphingosylphosphorylcholine and galactosylsphingosine in HL60 leukemia cells. Implications of GTP-binding protein-coupled receptors for lysosphingolipids.
Leukemia
Phospholipase C activates protein kinase C and induces monocytic differentiation of HL-60 cells.
Leukemia
Phospholipase C-gamma 1 is translocated to the membrane of rat basophilic leukemia cells in response to aggregation of IgE receptors.
Leukemia
Phospholipase C-induced monocytic differentiation in a human monocytic leukemia cell line THP-1.
Leukemia
Role of the phospholipase C-inositol 1,4,5-trisphosphate pathway in calcium release-activated calcium current and capacitative calcium entry.
Leukemia
Signal amplification in HL-60 granulocytes. Evidence that the chemotactic peptide receptor catalytically activates guanine-nucleotide-binding regulatory proteins in native plasma membranes.
Leukemia
Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and phospholipase C gamma 1 are required for NF-kappa B activation and lipid raft recruitment of protein kinase C theta induced by T cell costimulation.
Leukemia
The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis.
Leukemia
Translocation of phospholipase C-gamma 2 induced by in vitro activation of protein tyrosine kinase activity in mast cell lysates.
Leukemia L1210
Combination chemotherapy with Clostridium perfringens phospholipase C and cytosine antimetabolites: complementary inhibition directed at membrane lipids.
Leukemia, Erythroblastic, Acute
Immunocytochemical detection of the intranuclear variations of phosphatidylinositol 4,5-bisphosphate amount associated with changes of activity and amount of phospholipase C beta 1 in cells exposed to mitogenic or differentiating agonists.
Leukemia, Erythroblastic, Acute
Inositide-dependent phospholipase C signaling mimics insulin in skeletal muscle differentiation by affecting specific regions of the cyclin D3 promoter.
Leukemia, Erythroblastic, Acute
Inositides in the nucleus: further developments on phospholipase C beta 1 signalling during erythroid differentiation and IGF-I induced mitogenesis.
Leukemia, Erythroblastic, Acute
Molecular forms of acetylcholinesterase in two sublines of human erythroleukemia K562 cells. Sensitivity or resistance to phosphatidylinositol-specific phospholipase C and biosynthesis.
Leukemia, Erythroblastic, Acute
Nuclear but not cytoplasmic phospholipase C beta 1 inhibits differentiation of erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Nuclear phospholipase C beta1 (PLCbeta1) affects CD24 expression in murine erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Nuclear PLCbeta(1) acts as a negative regulator of p45/NF-E2 expression levels in Friend erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Phosphoinositide signaling in nuclei of Friend cells: phospholipase C beta down-regulation is related to cell differentiation.
Leukemia, Erythroblastic, Acute
Phosphoinositide signaling in nuclei of Friend cells: tiazofurin down-regulates phospholipase C beta 1.
Leukemia, Lymphocytic, Chronic, B-Cell
A novel somatic PLCG2 variant associated with resistance to BTK and SYK inhibition in chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Clonal evolution leading to ibrutinib resistance in chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Dissection of subclonal evolution by temporal mutation profiling in chronic lymphocytic leukemia patients treated with ibrutinib.
Leukemia, Lymphocytic, Chronic, B-Cell
PLCG2 C2 domain mutations co-occur with BTK and PLCG2 resistance mutations in chronic lymphocytic leukemia undergoing ibrutinib treatment.
Leukemia, Lymphocytic, Chronic, B-Cell
Using high-sensitivity sequencing for the detection of mutations in BTK and PLC?2 genes in cellular and cell-free DNA and correlation with progression in patients treated with BTK inhibitors.
Leukemia, Lymphoid
Altered signal transduction secondary to surface IgM cross-linking on B-chronic lymphocytic leukemia cells. Differential activation of the phosphatidylinositol-specific phospholipase C.
Leukemia, Myeloid, Acute
AS-1411, a guanosine-rich oligonucleotide aptamer targeting nucleolin for the potential treatment of cancer, including acute myeloid leukemia.
Leukemia, Myeloid, Acute
Phospholipase C Beta 2 Protein Overexpression Is a Favorable Prognostic Indicator in Newly Diagnosed Normal Karyotype Acute Myeloid Leukemia.
Leukemia, T-Cell
Interaction of CD4:lck with the T cell receptor/CD3 complex induces early signaling events in the absence of CD45 tyrosine phosphatase.
Leukemia-Lymphoma, Adult T-Cell
Clinical Applications of Genomic Alterations in ATLL: Predictive Markers and Therapeutic Targets.
Leukemia-Lymphoma, Adult T-Cell
Genomic landscape of young ATLL patients identifies frequent targetable CD28 fusions.
Leukocytosis
Evaluation of clinical characteristics, diagnostic test results, and outcome in horses with internal infection caused by Corynebacterium pseudotuberculosis: 30 cases (1995-2003).
Leukopenia
Radioprotective effects of black seed (Nigella sativa) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats.
Leukopenia
[Synergy and attenuation of cyclophosphamidum (CTX) activities by abalone polysaccharide]
Lewy Body Disease
Association of ABI3 and PLCG2 missense variants with disease risk and neuropathology in Lewy body disease and progressive supranuclear palsy.
Lipidoses
Deficiency of phospholipase C acting on phosphatidylglycerol in Niemann-Pick disease.
Listeriosis
Factors involved in the depression of hepatic mixed function oxidase during infections with Listeria monocytogenes.
Listeriosis
Factors involved in the down-regulation of cytochrome P450 during Listeria monocytogenes infection.
Listeriosis
Phosphatidylcholine-specific phospholipase C from Listeria monocytogenes is an important virulence factor in murine cerebral listeriosis.
Listeriosis
Role in virulence of phospholipases, listeriolysin O and listeriolysin S from epidemic Listeria monocytogenes using the chicken embryo infection model.
Liver Abscess
Identification and partial characterization of an Actinomyces pyogenes hemolysin.
Liver Cirrhosis
A clinical and radiologic study of primary liver cancer associated with extrahepatic primary cancer.
Liver Cirrhosis
Characteristics and prognosis of primary liver cancer in young patients in China.
Liver Cirrhosis
Clinicomorphological manifestations of primary liver carcinoma (PLC) in liver cirrhosis.
Liver Cirrhosis
Deficient phospholipase C activity in blood polimorphonuclear neutrophils from patients with liver cirrhosis.
Liver Cirrhosis
Incidence of primary liver cancer and aetiological aspects: a study of a defined population from a low-endemicity area.
Liver Cirrhosis
Lack of association between acute exposure to ionizing radiation and liver cirrhosis.
Liver Cirrhosis
Primary liver carcinoma -- clinical picture and diagnostic possibilities. A review of seventy-five cases.
Liver Cirrhosis
Relationship between intestinal microbial dysbiosis and primary liver cancer.
Liver Cirrhosis
Steroid hormone profiles plus ?-fetoprotein for diagnosing primary liver cancer by liquid chromatography tandem mass spectrometry.
Liver Cirrhosis
Whole-exome mutational and transcriptional landscapes of combined hepatocellular cholangiocarcinoma and intrahepatic cholangiocarcinoma reveal molecular diversity.
Liver Cirrhosis
[Clinicopathologic characteristics of primary liver cancer in patients younger than 35 years]
Liver Cirrhosis
[Guideline for stratified screening and surveillance of primary liver cancer(2020 Edition)].
Liver Cirrhosis
[Longitudinal study of aflatoxin exposure in the development of primary liver cancer in patients with chronic hepatitis].
Liver Cirrhosis
[Serum glycoprotein profiling by lectin affinity microarray to distinguish the various stages of primary liver carcinogenesis].
Liver Cirrhosis
[Significance of serum alpha-fetoprotein determination. Experiences with our own radioimmunoassay]
Liver Cirrhosis, Alcoholic
The role of diabetes in hepatocellular carcinoma: a case-control study among United States Veterans.
Liver Cirrhosis, Alcoholic
Unexpected high incidence of primary liver cancer in Geneva, Switzerland.
Liver Cirrhosis, Alcoholic
[Current estimate of the number of patients for liver transplantation with Dutch mortality figures]
Liver Diseases
Diagnosis of primary liver cancer using lectin affinity chromatography of serum alkaline phosphatase.
Liver Diseases
Expanding the Liver Imaging Reporting and Data System (LI-RADS) v2018 diagnostic population: performance and reliability of LI-RADS for distinguishing hepatocellular carcinoma (HCC) from non-HCC primary liver carcinoma in patients who do not meet strict LI-RADS high-risk criteria.
Liver Diseases
Increased porphyrins in primary liver cancer mainly reflect a parallel liver disease.
Liver Diseases
Phosphoinositide-specific phospholipase C in normal human liver and in alcohol abuse.
Liver Diseases
Primary liver carcinoma and liver cirrhosis in atomic bomb survivors, Hiroshima and Nagasaki, 1961-75, with special reference to hepatitis B surface antigen.
Liver Diseases
Prognostic value of LI-RADS category on gadoxetic acid-enhanced MRI and 18F-FDG PET-CT in patients with primary liver carcinomas.
Liver Diseases
The association between individual metabolic syndrome components, primary liver cancer and cirrhosis: A study in the Swedish AMORIS cohort.
Liver Diseases
The role of diabetes in hepatocellular carcinoma: a case-control study among United States Veterans.
Liver Diseases
[Association between Helicobacter infection in liver tissue and primary liver carcinoma]
Liver Diseases
[Current estimate of the number of patients for liver transplantation with Dutch mortality figures]
Liver Diseases, Alcoholic
Phosphoinositide-specific phospholipase C in normal human liver and in alcohol abuse.
Liver Neoplasms
A 13-Year Retrospective Study on Primary Liver Cancer in Cambodia: A Strikingly High Hepatitis C Occurrence among Hepatocellular Carcinoma Cases.
Liver Neoplasms
A comparison of trends in mortality from primary liver cancer and intrahepatic cholangiocarcinoma in Europe.
Liver Neoplasms
A comprehensive method for predicting fatal liver failure of patients with liver cancer resection.
Liver Neoplasms
A TNFR2-hnRNPK Axis Promotes Primary Liver Cancer Development via Activation of YAP Signaling in Hepatic Progenitor Cells.
Liver Neoplasms
Analysis of one hundred and twenty five patients with primary liver cancer surviving more than five years.
Liver Neoplasms
Application of an extreme learning machine network with particle swarm optimization in syndrome classification of primary liver cancer.
Liver Neoplasms
Are polymorphisms of N-acetyltransferase genes susceptible to primary liver cancer in Luoyang, China?
Liver Neoplasms
Changes of phosphatidylcholine-specific phospholipase C in hepatocarcinogenesis and in the proliferation and differentiation of rat liver cancer cells.
Liver Neoplasms
Clinical practice guidelines for the treatment of primary liver cancer with integrative traditional Chinese and Western medicine.
Liver Neoplasms
Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay.
Liver Neoplasms
Diagnosis of primary liver cancer using lectin affinity chromatography of serum alkaline phosphatase.
Liver Neoplasms
Effects of HGF gene polymorphisms and protein expression on transhepatic arterial chemotherapeutic embolism efficacy and prognosis in patients with primary liver cancer.
Liver Neoplasms
Freshwater cyanobacterial blooms and primary liver cancer epidemiological studies in Serbia.
Liver Neoplasms
Global trend of aetiology-based primary liver cancer incidence from 1990 to 2030: a modelling study.
Liver Neoplasms
Hepatitis B virus and primary liver cancer on Chongming Island, People's Republic of China.
Liver Neoplasms
Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.
Liver Neoplasms
IFI44L is a novel tumor suppressor in human hepatocellular carcinoma affecting cancer stemness, metastasis, and drug resistance via regulating met/Src signaling pathway.
Liver Neoplasms
Incidence of primary liver cancer in Italy between 1988 and 2002: an age-period-cohort analysis.
Liver Neoplasms
Magnesium intake and primary liver cancer incidence and mortality in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.
Liver Neoplasms
Nonassociation of aflatoxin with primary liver cancer in a cross-sectional ecological survey in the People's Republic of China.
Liver Neoplasms
Practice guidelines for the pathological diagnosis of primary liver cancer: 2015 update.
Liver Neoplasms
Primary liver cancer and survival in patients undergoing liver transplantation for hemochromatosis.
Liver Neoplasms
Prospective evaluation of type 2 diabetes mellitus on the risk of primary liver cancer in Chinese men and women.
Liver Neoplasms
Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer.
Liver Neoplasms
Regulation of Shaoyao Ruangan Mixture on Intestinal Flora in Mice With Primary Liver Cancer.
Liver Neoplasms
Surgical approaches for improving the operating results of primary liver cancer.
Liver Neoplasms
Systematic Elucidation of the Potential Mechanisms of Core Chinese Materia Medicas in Treating Liver Cancer Based on Network Pharmacology.
Liver Neoplasms
Temporal changes in liver cancer incidence rates in Japan: accounting for death certificate inaccuracies and improving diagnostic techniques.
Liver Neoplasms
Treatment of primary liver cancer -- with special reference to the east part of China.
Liver Neoplasms
[A study on primary liver cancer in tree shrews induced by human hepatitis B virus and aflatoxin B1]
Liver Neoplasms
[A thirty-one year prospective follow-up program on the HBsAg carrier state and primary liver cancer in Qidong, China.]
Liver Neoplasms
[An epidemiologic study on the aetiological factors of primary liver cancer in Shunde City of Guangdong province]
Liver Neoplasms
[Correlation between polymorphisms in the human leukocyte antigen-DQB1 alleles and hepatitis B with primary hepatocellular carcinoma].
Liver Neoplasms
[Expression and clinical significance of nerve growth factor in primary liver cancer].
Liver Neoplasms
[Long-term prognosis after hepatic resection for huge primary liver cancer]
Liver Neoplasms
[Multiple pathogenic factors analysis on primary liver cancer the role of HBV infection combined with other risk factors in the occurrence of PLC]
Liver Neoplasms
[Preliminary observations on effect of selenium yeast on high risk populations with primary liver cancer]
Liver Neoplasms
[Prognosis and risk factors for recurrence of small liver cancer after a single session of percutaneous radiofrequency ablation]
Liver Neoplasms
[Serum glycoprotein profiling by lectin affinity microarray to distinguish the various stages of primary liver carcinogenesis].
Liver Neoplasms
[The value of serum alpha-L-fucosidase activity in the diagnosis of primary liver cancer]
Liver Neoplasms, Experimental
Increased activity and nuclear localisation of inositol lipid signal transduction enzymes in rat hepatoma cells.
Lordosis
In the ventral tegmental area, progestogens' membrane-mediated actions for lordosis of rats involve the second-messenger phospholipase C.
Lordosis
In the ventral tegmental area, the membrane-mediated actions of progestins for lordosis of hormone-primed hamsters involve phospholipase C and protein kinase C.
Lordosis
Membrane actions of progestins at dopamine type 1-like and GABAA receptors involve downstream signal transduction pathways.
Lordosis
[Long-term effectiveness of posterior lumbar interbody fusion of retaining posterior ligamentous complex].
Lung Diseases
Distribution of phospholipase C isozymes in normal human lung tissue and their immunohistochemical localization.
Lung Diseases, Interstitial
Correlation of spicule sign on computed tomography scans with peripheral lung cancers associated with interstitial lung disease and chronic obstructive pulmonary disease.
Lung Diseases, Interstitial
Lung damage caused by phospholipase C and the changes in phospholipids in the rat lung.
Lung Diseases, Interstitial
Pulmonary lymphangitis carcinomatosis: systematic review and meta-analysis of case reports, 1970-2018.
Lung Injury
E. coli virulence factor hemolysin induces neutrophil apoptosis and necrosis/lysis in vitro and necrosis/lysis and lung injury in a rat pneumonia model.
Lung Injury
Surfactant dysfunction and lung injury due to the E. coli virulence factor hemolysin in a rat pneumonia model.
Lung Neoplasms
Association Between Polymorphisms in COMT, PLCH1, and CYP17A1, and Non-Small-Cell Lung Cancer Risk in Chinese Nonsmokers.
Lung Neoplasms
Chloroquine inhibits cell growth and induces cell death in A549 lung cancer cells.
Lung Neoplasms
Clinical relevance of intraoperative pleural lavage cytology in non-small cell lung cancer.
Lung Neoplasms
Clinical significance of pleural lavage cytology for non-small cell lung cancer: is surgical resection valid for patients with positive pleural lavage cytology?
Lung Neoplasms
Clinical significance of serum ferritin in elderly patients with primary lung carcinoma.
Lung Neoplasms
Development and Characterization of a Novel, High-Affinity, Specific, Radiolabeled Ligand for BRS-3 Receptors.
Lung Neoplasms
FGFR1 is critical for Rbl2 loss-driven tumor development and requires PLCG1 activation for continued growth of small cell lung cancer.
Lung Neoplasms
Genomic structure of the human PLCD1 (phospholipase C delta 1) locus on 3p22-->p21.3.
Lung Neoplasms
High expression of DLC family proteins predicts better prognosis and inhibits tumor progression in NSCLC.
Lung Neoplasms
Identification of gene markers in the development of smoking-induced lung cancer.
Lung Neoplasms
Intrapleural chemotherapy improves the survival of non-small cell lung cancer patients with positive pleural lavage cytology.
Lung Neoplasms
Melatonin reduces lung cancer stemness through inhibiting of PLC, ERK, p38, ?-catenin, and Twist pathways.
Lung Neoplasms
Microflow imaging of contrast-enhanced ultrasound for evaluation of neovascularization in peripheral lung cancer.
Lung Neoplasms
Novel genetic variants in genes of the Fc gamma receptor-mediated phagocytosis pathway predict non-small cell lung cancer survival.
Lung Neoplasms
Novel water-soluble derivatives of docosahexaenoic acid increase diacylglycerol production mediated by phosphatidylcholine-specific phospholipase C.
Lung Neoplasms
Pleural invasion, epidermal growth factor receptor mutation and carcinoembryonic antigen level affect pleural lavage cytology-positive status in non-small-cell lung cancer.
Lung Neoplasms
Pleural lavage cytology immediately after thoracotomy and before closure of the thoracic cavity for lung cancer without pleural effusion and dissemination: clinicopathologic and prognostic analysis.
Lung Neoplasms
Positive pre-resection pleural lavage cytology is associated with increased risk of lung cancer recurrence in patients undergoing surgical resection: a meta-analysis of 4450 patients.
Lung Neoplasms
Prognostic impact of pleural lavage cytology in patients with primary lung cancer.
Lung Neoplasms
Prognostic significance and possibility in guiding adjuvant therapy of the pleural lavage cytology in patients with non-small cell lung cancer.
Lung Neoplasms
Prognostic significance of pleural lavage cytology in patients with lung cancer: a meta-analysis.
Lung Neoplasms
Prognostic value of intraoperative pleural lavage cytology for lung cancer without carcinomatous pleuritis: importance in patients with early stage disease during long-term follow-up.
Lung Neoplasms
Prognostic Value of Pleural Lavage Cytology in Patients with Lung Cancer Resection: An Updated Meta-Analysis.
Lung Neoplasms
Pulmonary lymphangitic carcinomatosis: diagnostic performance of HRCT and 18F-FDG-PET/CT in correlation to clinical pathologic outcome.
Lung Neoplasms
Recurrence patterns in patients with early stage non-small cell lung cancers undergoing positive pleural lavage cytology.
Lung Neoplasms
Role of pleural lavage cytology before resection for primary lung carcinoma.
Lung Neoplasms
The influence of intraoperative pleural perfusion with matrine-cisplatin or cisplatin on stromal cell-derived factor-1 in non-small cell lung cancer patients with subclinical pleural metastasis.
Lung Neoplasms
The peripheral lymphocyte count as an aid in the clinical staging of lung cancer.
Lung Neoplasms
The value of pleural lavage cytology examined during surgery for primary lung cancer.
Lung Neoplasms
Value of wide-margin wedge resection for solitary pulmonary nodule: a single center experience.
Lung Neoplasms
Visceral pleura invasion and pleural lavage tumor cytology by lung cancer: a prospective appraisal.
Lung Neoplasms
[Recurrence patterns and prognosis in lung cancer patients with positive pleural lavage cytology at surgery]
Lung Neoplasms
[The influence of cryosurgery on great vessels and heart in patients with lung cancer.]
Lupus Erythematosus, Systemic
Investigation of Phospholipase C?1 Interaction with SLP76 Using Molecular Modeling Methods for Identifying Novel Inhibitors.
Lupus Nephritis
Series test of cluster and network analysis for lupus nephritis, before and after IFN-K-immunosuppressive therapy.
Luteoma
Alterations in intracellular messengers mobilized by gonadotropin-releasing hormone in an experimental ovarian tumor.
Lymphatic Metastasis
A Comparison of the Pathological Types of Undifferentiated Carcinoma of the Pancreas.
Lymphatic Metastasis
Expression of phospholipase C isozymes in human breast cancer and their clinical significance.
Lymphatic Metastasis
Molecular characterization and significance for prognosis of free gastric cancer cells in the peritoneal cavity.
Lymphatic Metastasis
Peritoneal lavage cytology and carcinoembryonic antigen determination in predicting peritoneal metastasis and prognosis of gastric cancer.
Lymphatic Metastasis
Pleomorphic lobular carcinoma of the breast: a comparison of cytopathological features with other lobular carcinoma variants.
Lymphatic Metastasis
Positive Intraoperative Peritoneal Lavage Cytology is a Negative Prognostic Factor in Pancreatic Ductal Adenocarcinoma: A Retrospective Single-Center Study.
Lymphatic Metastasis
Relevance of Intraoperative Pleural Lavage Cytology and Histologic Subtype in Lung Adenocarcinoma.
Lymphedema
Breast cancer cutaneous metastases mimicking Papilloma Cutis Lymphostatica. Biopsy to avoid pitfalls.
Lymphocytic Choriomeningitis
Lymphocytic choriomeningitis virus. VII. Structural alterations of the virion by treatment with proteolytic enzymes without loss of infectivity.
Lymphocytosis
'Prolymphocytoid' cells in chronic lymphocytic leukaemia and their prognostic significance.
Lymphoma
Apicidin decreases phospholipase C gamma-1 transcript and protein in Hut-78 T lymphoma cells.
Lymphoma
Atypical manifestations of pityriasis lichenoides chronica: development into paraneoplasia and non-Hodgkin lymphomas of the skin.
Lymphoma
Cytosolic phospholipase C activity: I. Evidence for coupling with cytosolic guanine nucleotide-binding protein, Gi alpha.
Lymphoma
EGFR mutation genotyping and ALK status determination in liquid-based cytology samples of non-small cell lung cancer.
Lymphoma
Inhibition of the transport function of membrane proteins by some substituted phenothiazines in E. coli and multidrug resistant tumor cells.
Lymphoma
Insights into the structural specificity of the cytotoxicity of 3-deoxyphosphatidylinositols.
Lymphoma
Interactions between a lymphoma membrane-associated guanosine 5'-triphosphate-binding protein and the cytoskeleton during receptor patching and capping.
Lymphoma
Interferon-mediated intracellular signalling. Modulation of different phospholipase activities in Burkitt lymphoma cells.
Lymphoma
Involvement of a guanine-nucleotide-binding component in membrane IgM-stimulated phosphoinositide breakdown.
Lymphoma
Pityriasis lichenoids chronica as a paraneoplastic dermatosis for primary splenic diffuse large B cell lymphoma.
Lymphoma
Presence of prelymphoma cells in the bone marrow of the lymphomagenic virus-treated AKR mouse.
Lymphoma
Prevention of spontaneous AKR T cell lymphomagenesis by 24-666, a virus isolated from an AKR B cell lymphoma.
Lymphoma
Prevention of spontaneous AKR T cell lymphomagenesis by elimination of potential lymphoma cells with antibody to specific gp 71 determinants.
Lymphoma
Short Stat5-interacting peptide derived from phospholipase C-?3 inhibits hematopoietic cell proliferation and myeloid differentiation.
Lymphoma
Systematic Review of Cases of Cutaneous T-Cell Lymphoma Transformation in Pityriasis Lichenoides and Small Plaque Parapsoriasis.
Lymphoma
The effects of passive anti-viral immunotherapy in AKR mice: II. Susceptibility to B cell lymphomagenesis.
Lymphoma
The G protein coupling T cell antigen receptor/CD3-complex and phospholipase C in the human T cell lymphoma Jurkat is not a target for cholera toxin.
Lymphoma
Tyrosine protein kinase is involved in anti-IgM-mediated signaling in BAL17 B lymphoma cells.
Lymphoma, B-Cell
Pityriasis lichenoids chronica as a paraneoplastic dermatosis for primary splenic diffuse large B cell lymphoma.
Lymphoma, B-Cell
The effects of passive anti-viral immunotherapy in AKR mice: II. Susceptibility to B cell lymphomagenesis.
Lymphoma, B-Cell, Marginal Zone
A Gain-Of-Function Mutation in the Plcg2 Gene Protects Mice from Helicobacter felis-Induced Gastric MALT Lymphoma.
Lymphoma, Non-Hodgkin
Atypical manifestations of pityriasis lichenoides chronica: development into paraneoplasia and non-Hodgkin lymphomas of the skin.
Lymphoma, Non-Hodgkin
Effect of exogenous immunogenic RNA on the antibody synthesis in rat transplantable lymphosarcoma cells.
Lymphoma, Non-Hodgkin
Ofatumumab, a human monoclonal antibody for lymphoid malignancies and autoimmune disorders.
Lymphoma, Non-Hodgkin
The ability of rat transplantable lymphosarcoma cells to synthesize immunoglobulins.
Lymphoma, Non-Hodgkin
[Intercellular information flow in the process of immunogenesis. VII. The effect of low- and high-polymer immune nuclear RNA on antibody synthesis by the cells of rat transplantable]U.
Lymphoma, T-Cell
Prevention of spontaneous AKR T cell lymphomagenesis by elimination of potential lymphoma cells with antibody to specific gp 71 determinants.
Lymphoma, T-Cell
The G protein coupling T cell antigen receptor/CD3-complex and phospholipase C in the human T cell lymphoma Jurkat is not a target for cholera toxin.
Lymphoma, T-Cell, Cutaneous
Frequent and persistent PLCG1 mutations in Sézary cells directly enhance PLC?1 activity and stimulate NF?B, AP-1 and NFAT signaling. Short title: Gain-of-function PLCG1 mutations in Sézary Syndrome.
Lymphoma, T-Cell, Cutaneous
Oncogenomic analysis identifies novel biomarkers for tumor stage mycosis fungoides.
Lymphoma, T-Cell, Cutaneous
PLCG1 Gene Mutations Are Uncommon in Cutaneous T-Cell Lymphomas.
Lymphoma, T-Cell, Peripheral
Recurrent presence of the PLCG1 S345F mutation in nodal peripheral T-cell lymphomas.
Lymphopenia
Chemotherapy is a risk factor of lymphopenia before adjuvant radiotherapy in breast cancer.
Lymphoproliferative Disorders
Differentiation and clonality of lesional lymphocytes in pityriasis lichenoides chronica.
Lymphoproliferative Disorders
Pityriasis lichenoides: pathophysiology, classification, and treatment.
Macular Degeneration
Pathway Analysis Integrating Genome-Wide and Functional Data Identifies PLCG2 as a Candidate Gene for Age-Related Macular Degeneration.
Macular Edema
Real-World Assessment of Dexamethasone Intravitreal Implant in DME: Findings of the Prospective, Multicenter REINFORCE Study.
Malaria
Discontinuing cotrimoxazole preventive therapy in HIV-infected adults who are stable on antiretroviral treatment in Uganda (COSTOP): A randomised placebo controlled trial.
Malaria
Plasmodium falciparum phospholipase C hydrolyzing sphingomyelin and lysocholinephospholipids is a possible target for malaria chemotherapy.
Mania
Dysbalance of neuronal second messenger function in the aetiology of affective disorders: a pathophysiological concept hypothesising defects beyond first messenger receptors.
Mania
Neuropsychiatric assessment as a secondary outcome measure in a multiple sclerosis intravenous immunoglobulin L(IMg) trial.
Mastitis
Biofilm formation, hemolysin production and antimicrobial susceptibilities of Streptococcus agalactiae isolated from the mastitis milk of dairy cows in Shahrekord district, Iran.
Mastitis
Development and evaluation of vaccine against Staphylococcus aureus recovered from naturally occurring mastitis in she-camels.
Mastitis
Virulence of Staphylococcus aureus in a mouse mastitis model: studies of alpha hemolysin, coagulase, and protein A as possible virulence determinants with protoplast fusion and gene cloning.
Mastitis
[Characteristics of the staphylococci isolated from the udder of cows with mastitis]
Mastitis
[Effect of antibiotics on hemolysin production by bacteria causing mastitis in cattle]
Mastocytosis
Altered Metabolism of Phospholipases, Diacylglycerols, Endocannabinoids, and N-Acylethanolamines in Patients with Mastocytosis.
Measles
Analysis of the molecules involved in human T-cell leukaemia virus type 1 entry by a vesicular stomatitis virus pseudotype bearing its envelope glycoproteins.
Measles
Complement activation by measles virus cytotoxic antibodies: alternative pathway C activation by hemagglutination-inhibition antibodies but classical activation by hemolysin antibodies.
Measles
Detection of measles antibodies in cerebrospinal fluid and serum by a radioimmunoassay.
Measles
Further elucidation of the nature of the measles virus hemolysin based on inactivation studies.
Measles
Humoral immunity to canine distemper after immunization of dogs with inactivated and live measles virus.
Measles
Polar appearance and nonligand induced spreading of measles virus hemagglutinin at the surface of chronically infected cells.
Measles
Use of a radioimmune assay in detection of measles antibodies in cerebrospinal fluid and serum.
Measles
Viral antibody titers. Comparison in patients with multiple sclerosis and rheumatoid arthritis.
Melanoma
A 6 year prospective analysis of the diagnosis of malignant melanoma in a pigmented-lesion clinic: even the experts miss malignant melanomas, but not often.
Melanoma
Characterization of phosphatidylinositol phospholipase C activity in human melanoma.
Melanoma
Comparison of diagnostic accuracy for cutaneous malignant melanoma between general dermatology, plastic surgery and pigmented lesion clinics.
Melanoma
Compartment-Specific Biosensors Reveal a Complementary Subcellular Distribution of Bioactive Furin and PC7.
Melanoma
Digital Dermoscopy Photographs Outperform Handheld Dermoscopy in Melanoma Diagnosis.
Melanoma
Frequency and characteristics of melanomas missed at a pigmented lesion clinic: a registry-based study.
Melanoma
Improved malignant melanoma prognosis at a consultant-delivered multidisciplinary pigmented lesion clinic in Cork.
Melanoma
Involvement of phospholipase C signaling in melanoma cell-induced endothelial junction disassembly.
Melanoma
Melanoma detection rate and concordance between self-skin examination and clinical evaluation in patients attending a pigmented lesion clinic in Italy.
Melanoma
Melanoma diagnosis and management after the introduction of a pigmented lesion clinic in the Mid-West of Ireland.
Melanoma
Melanoma yield, number of biopsies and missed melanomas in a British teaching hospital pigmented lesion clinic: a 9-year retrospective study.
Melanoma
Multidisciplinary Pigmented Lesion Clinic at Auckland District Health Board: impacts on melanoma diagnosis and treatment outcomes.
Melanoma
Pharmacogenomics of metabotropic glutamate receptor subtype 1 and in vivo malignant melanoma formation.
Melanoma
Phospholipase C from human melanoma: purification and characterization of a phosphatidylinositol-selective enzyme.
Melanoma
Secondary Somatic Mutations in G-Protein-Related Pathways and Mutation Signatures in Uveal Melanoma.
Melanoma
The effect of the introduction of a pigmented lesion clinic on the interval between referral by family practitioner and attendance at hospital.
Melanoma
The impact of total body photography on biopsy rate in patients from a pigmented lesion clinic.
Melanoma
The problem of false-positive diagnosis in melanoma screening: the impact of dermoscopy.
Melanoma
The UK Government two-week rule and its impact on melanoma prognosis: an evidence-based study.
Melanoma
Use of an early-detection strategy to improve disease control in melanoma patients.
Melanoma, Experimental
Growth of melanocytic cells is associated with down-regulation of protein kinase C alpha, delta, and epsilon isoforms. Possible role of diacylglycerol.
Melioidosis
Cloning and characterization of a nonhemolytic phospholipase C gene from Burkholderia pseudomallei.
Melioidosis
Comparison of O-polysaccharide and hemolysin co-regulated protein as target antigens for serodiagnosis of melioidosis.
Melioidosis
Distinct classes and subclasses of antibodies to hemolysin co-regulated protein 1 and O-polysaccharide and correlation with clinical characteristics of melioidosis patients.
Melioidosis
Functional redundancy of Burkholderia pseudomallei phospholipase C enzymes and their role in virulence.
Melioidosis
Genome-Wide Expression Analysis of Burkholderia pseudomallei Infection in a Hamster Model of Acute Melioidosis.
Meningioma
Calcium channel antagonist effect on in vitro meningioma signal transduction pathways after growth factor stimulation.
Meningitis
Relatedness of Streptococcus suis isolates of various serotypes and clinical backgrounds as evaluated by macrorestriction analysis and expression of potential virulence traits.
Meningitis
Serotypes, hemolysin production, and receptor recognition of Escherichia coli strains associated with neonatal sepsis and meningitis.
Menorrhagia
Phospholipase activity in the endometrium of women with normal menstrual blood loss and women with proven ovulatory menorrhagia.
Menorrhagia
Phospholipase C activity in human endometrium: its significance in endometrial pathology.
Mesothelioma
Pseudomesotheliomatous lung cancer mimicking mesothelioma on (18)F-FDG PET/CT images: report of 2 cases.
Mesothelioma, Malignant
Pseudomesotheliomatous lung cancer mimicking mesothelioma on (18)F-FDG PET/CT images: report of 2 cases.
Metabolic Syndrome
A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains.
Metabolic Syndrome
Association and interaction of APOA5, BUD13, CETP, LIPA and health-related behavior with metabolic syndrome in a Taiwanese population.
Migraine Disorders
Phospholipase C activity increases in cerebrospinal fluid from migraineurs in proportion to the number of comorbid conditions: a case-control study.
Migraine Disorders
Real-world effectiveness of onabotulinumtoxinA treatment for the prevention of headaches in adults with chronic migraine in Australia: a retrospective study.
Mouth Neoplasms
Effect of m-3m3FBS on Ca2+ handling and viability in OC2 human oral cancer cells.
Movement Disorders
Two Hundred Twenty-Six Consecutive Deep Brain Stimulation Electrodes Placed Using an "Asleep" Technique and the Neuro|MateTM Robot for the Treatment of Movement Disorders.
Multiple Sclerosis
A new multiple sclerosis spasticity treatment option: effect in everyday clinical practice and cost-effectiveness in Germany.
Multiple Sclerosis
Ofatumumab, a human monoclonal antibody for lymphoid malignancies and autoimmune disorders.
Multiple Sclerosis
Pathological laughing and crying in multiple sclerosis: a preliminary report suggesting a role for the prefrontal cortex.
Multiple Sclerosis
PLCG2 rs72824905 Variant Reduces the Risk of Alzheimer's Disease and Multiple Sclerosis.
Multiple Sclerosis
Posterior Fossa Lesion Load and Pathological Laughing and Crying in Multiple Sclerosis.
Multiple Sclerosis
Viral antibody titers. Comparison in patients with multiple sclerosis and rheumatoid arthritis.
Multiple System Atrophy
Pathological laughter and crying in multiple system atrophy with different subtypes: Frequency and related factors.
Mumps
Effect of spleen exposure to ultrasound on cellular and antibody-mediated immune reactions in man.
Mumps
STUDIES OF THE HEMOLYSIS OF RED BLOOD CELLS BY MUMPS VIRUS : I. THE DEVELOPMENT OF MUMPS VIRUS HEMOLYSIN AND ITS INACTIVATION BY CERTAIN PHYSICAL AND CHEMICAL AGENTS.
Muscle Cramp
Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation.
Muscle Spasticity
Coronary Vasospasm Induced in Transgenic Mouse With Increased Phospholipase C-?1 Activity.
Muscle Spasticity
Enhanced activity of variant phospholipase C-delta1 protein (R257H) detected in patients with coronary artery spasm.
Muscle Spasticity
Enhanced phospholipase C activity in the cultured skin fibroblast obtained from patients with coronary spastic angina: possible role for enhanced vasoconstrictor response.
Muscle Spasticity
IQGAP1 activates PLC-?1 by direct binding and moving along microtubule with DLC-1 to cell surface.
Muscular Dystrophy, Duchenne
PRO-051, an antisense oligonucleotide for the potential treatment of Duchenne muscular dystrophy.
Myasthenia Gravis
[Recent advance in research for myasthenia gravis, in relation to various antibodies affecting synaptic structure and function]
Mycoplasma Infections
Paroxysmal cold hemoglobinuria (P.C.H.) following mycoplasma infection: anti-I specificity of the biphasic hemolysin.
Mycosis Fungoides
Systematic Review of Cases of Cutaneous T-Cell Lymphoma Transformation in Pityriasis Lichenoides and Small Plaque Parapsoriasis.
Mydriasis
Assessment of diabetic retinopathy using two ultra-wide-field fundus imaging systems, the Clarus® and Optos systems.
Mydriasis
Ultra-wide-field scanning laser ophthalmoscopy assists in the clinical detection and evaluation of asymptomatic early-stage familial exudative vitreoretinopathy.
Myelodysplastic Syndromes
Reduced PLCG1 expression is associated with inferior survival for myelodysplastic syndromes.
Myocardial Infarction
Identification of changes in cardiac phospholipase C activity in congestive heart failure.
Myocardial Infarction
Improvement of cardiac function and beta-adrenergic signal transduction by propionyl L-carnitine in congestive heart failure due to myocardial infarction.
Myocardial Infarction
Propionyl-L-carnitine limits chronic ventricular dilation after myocardial infarction in rats.
Myocardial Ischemia
Different Expression and Function of the Endocannabinoid System in Human Epicardial Adipose Tissue in Relation to Heart Disease.
Myocardial Ischemia
Phospholipase C-delta1 rescues intracellular Ca2+ overload in ischemic heart and hypoxic neonatal cardiomyocytes.
Myocardial Ischemia
Protective effects of protein kinase C during myocardial ischemia require activation of phosphatidyl-inositol specific phospholipase C.
Myocardial Ischemia
Sarcoplasmic reticulum dysfunction: phospholipid alterations induced by lysosomal phospholipase C.
Myotoxicity
Clostridium perfringens phospholipase C induced ROS production and cytotoxicity require PKC, MEK1 and NF?B activation.
Nasal Polyps
The role of protein kinase C in alpha-adrenergic regulation of NaCl(K) cotransport in human airway epithelial cells.
Neonatal Sepsis
Heterogeneity of hemolysin expression during neonatal Streptococcus agalactiae sepsis.
Neonatal Sepsis
Serotypes, hemolysin production, and receptor recognition of Escherichia coli strains associated with neonatal sepsis and meningitis.
Neoplasm Metastasis
A case of fatal respiratory failure after surgery for advanced supraglottic laryngeal carcinoma.
Neoplasm Metastasis
A clinical and radiologic study of primary liver cancer associated with extrahepatic primary cancer.
Neoplasm Metastasis
A Comparison of the Pathological Types of Undifferentiated Carcinoma of the Pancreas.
Neoplasm Metastasis
A new view of the roles of blood flow dynamics and Kupffer cell in intra-hepatic metastasis of hepatocellular carcinoma.
Neoplasm Metastasis
Association between the expression of HIF-1? and VEGF and prognostic implications in primary liver cancer.
Neoplasm Metastasis
Biological significance of genome-wide DNA methylation profiles in keloids.
Neoplasm Metastasis
Central liver toxicity after SBRT: An expanded analysis and predictive nomogram.
Neoplasm Metastasis
Characterization of a novel tumor-suppressor gene PLC delta 1 at 3p22 in esophageal squamous cell carcinoma.
Neoplasm Metastasis
Clinicopathologic and biomarker analysis of invasive pleomorphic lobular carcinoma as compared with invasive classic lobular carcinoma: an experience in our institution and review of the literature.
Neoplasm Metastasis
Combined hepatocellular-cholangiocarcinoma: An analysis of clinicopathological characteristics after surgery.
Neoplasm Metastasis
Correlation between expression levels of PTEN and p53 genes and the clinical features of HBsAg-positive liver cancer.
Neoplasm Metastasis
Correlations of pri-Let-7 gene polymorphisms with the recurrence and metastasis of primary liver cancer after transcatheter arterial chemoembolization.
Neoplasm Metastasis
Detection of phosphatidylcholine-specific phospholipase C in NIH-3T3 fibroblasts and their H-ras transformants: NMR and immunochemical studies.
Neoplasm Metastasis
EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells.
Neoplasm Metastasis
Expression of MUC1 and its significance in hepatocellular and cholangiocarcinoma tissue.
Neoplasm Metastasis
Expression of phospholipase C isozymes in human breast cancer and their clinical significance.
Neoplasm Metastasis
Expressions of Lewis antigens in human non-small cell pulmonary cancer and primary liver cancer with different pathological conditions.
Neoplasm Metastasis
Functional roles of PC-PLC and Cdc20 in the cell cycle, proliferation, and apoptosis.
Neoplasm Metastasis
Impact of Low-Dose Computed Tomography Screening for Primary Lung Cancer on Subsequent Risk of Brain Metastasis.
Neoplasm Metastasis
Increased porphyrins in primary liver cancer mainly reflect a parallel liver disease.
Neoplasm Metastasis
Long-term results of surgery for small primary liver cancer in 514 adults.
Neoplasm Metastasis
Long-term survivors after resection for primary liver cancer. Clinical analysis of 19 patients surviving more than ten years.
Neoplasm Metastasis
Metastasis of the liver with a granulosa cell tumor of the ovary: A case report.
Neoplasm Metastasis
Micrometastasis in surrounding liver and the minimal length of resection margin of primary liver cancer.
Neoplasm Metastasis
miR-423-5p inhibits the proliferation and metastasis of glioblastoma cells by targeting phospholipase C beta 1.
Neoplasm Metastasis
Molecular characterization and significance for prognosis of free gastric cancer cells in the peritoneal cavity.
Neoplasm Metastasis
Oncologic impact of lateral lymph node metastasis at the distal lateral compartment in locally advanced low rectal cancer after neoadjuvant (chemo)radiotherapy.
Neoplasm Metastasis
Pancreatic metastasis from invasive pleomorphic lobular carcinoma of the breast: a rare case report.
Neoplasm Metastasis
Peritoneal lavage cytology and carcinoembryonic antigen determination in predicting peritoneal metastasis and prognosis of gastric cancer.
Neoplasm Metastasis
PLC gamma contributes to metastasis of in situ-occurring mammary and prostate tumors.
Neoplasm Metastasis
PLC-beta2 is highly expressed in breast cancer and is associated with a poor outcome: a study on tissue microarrays.
Neoplasm Metastasis
Pleomorphic Invasive Lobular Carcinoma of the Male Breast: Two Case Reports with Opposite Hormone Receptor Status.
Neoplasm Metastasis
Pleomorphic lobular carcinoma of the breast: a comparison of cytopathological features with other lobular carcinoma variants.
Neoplasm Metastasis
Positive Intraoperative Peritoneal Lavage Cytology is a Negative Prognostic Factor in Pancreatic Ductal Adenocarcinoma: A Retrospective Single-Center Study.
Neoplasm Metastasis
Prognosis of non-small-cell lung cancer patients with positive pleural lavage cytology.
Neoplasm Metastasis
Prognostic significance and possibility in guiding adjuvant therapy of the pleural lavage cytology in patients with non-small cell lung cancer.
Neoplasm Metastasis
Prognostic significance of the neutrophil-to-lymphocyte ratio in primary liver cancer: a meta-analysis.
Neoplasm Metastasis
Relevance of Intraoperative Pleural Lavage Cytology and Histologic Subtype in Lung Adenocarcinoma.
Neoplasm Metastasis
Solitary Pulmonary Lesion in Patients with History of Malignancy: Primary Lung Cancer or Metastatic Cancer?
Neoplasm Metastasis
Spontaneous and iatrogenic spreading of liver-derived cells into peripheral blood of patients with primary liver cancer.
Neoplasm Metastasis
Squamous cell lung cancer presenting with pulmonary lymphangitic carcinomatosis.
Neoplasm Metastasis
Surgical Outcomes of Isolated Malignant Pulmonary Nodules in Patients with a History of Breast Cancer.
Neoplasm Metastasis
Temporal changes in liver cancer incidence rates in Japan: accounting for death certificate inaccuracies and improving diagnostic techniques.
Neoplasm Metastasis
The influence of intraoperative pleural perfusion with matrine-cisplatin or cisplatin on stromal cell-derived factor-1 in non-small cell lung cancer patients with subclinical pleural metastasis.
Neoplasm Metastasis
Thrombospondin-2 stimulates MMP-9 production and promotes osteosarcoma metastasis via the PLC, PKC, c-Src and NF-?B activation.
Neoplasm Metastasis
Trichostatin A reduced phospholipase C gamma-1 transcript and protein contents in MCF-7 breast cancer cells.
Neoplasm Metastasis
[Clinical implications of spontaneous and iatrogenic dissemination of tumor cells in patients with primary liver cancer]
Neoplasm Metastasis
[Long-term results of multimodality treatment in patients with primary liver cancer]
Neoplasm Metastasis
[Molecular markers and mechanisms for stemness maintenance of liver cancer stem cells: a review].
Neoplasm Metastasis
[Prophylaxis and clinical treatment for surgical margin recurrence of small primary hepatocellular carcinoma]
Neoplasm Micrometastasis
Micrometastasis in surrounding liver and the minimal length of resection margin of primary liver cancer.
Neoplasm Micrometastasis
[Prospective study of liver parenchyma volume in hepatectomy of primary liver cancer]
Neoplasms
A Case of Rapidly Deteriorating Lymphangitic Carcinomatosis in a Patient with Stage IV Pancreatic Cancer.
Neoplasms
A clinical and radiologic study of primary liver cancer associated with extrahepatic primary cancer.
Neoplasms
A new view of the roles of blood flow dynamics and Kupffer cell in intra-hepatic metastasis of hepatocellular carcinoma.
Neoplasms
A novel somatic PLCG2 variant associated with resistance to BTK and SYK inhibition in chronic lymphocytic leukemia.
Neoplasms
A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo.
Neoplasms
Absence of activating mutations of the genes encoding the alpha-subunits of G11 and Gq in thyroid neoplasia.
Neoplasms
Acid degradable poly(vinylcaprolactam)-based nanogels with ketal linkages for drug delivery.
Neoplasms
Activation of phosphatidylcholine cycle enzymes in human epithelial ovarian cancer cells.
Neoplasms
Activation of Phosphatidylcholine-Specific Phospholipase C in Breast and Ovarian Cancer: Impact on MRS-Detected Choline Metabolic Profile and Perspectives for Targeted Therapy.
Neoplasms
Activation of the epidermal growth factor receptor by skin tumor promoters and in skin tumors from SENCAR mice.
Neoplasms
Aflatoxin is not a probably human carcinogen: the published evidence is sufficient.
Neoplasms
Alpha(1)-and beta(2)-adrenoceptors in the human liver with mass-forming intrahepatic cholangiocarcinoma: density and coupling to adenylate cyclase and phospholipase C.
Neoplasms
Altered levels of phosphoinositide metabolites and activation of guanine-nucleotide dependent phospholipase C in rat hepatic tumors.
Neoplasms
An experimental study and clinical pilot trials on yttrium-90 glass microspheres through the hepatic artery for treatment of primary liver cancer.
Neoplasms
Analysis of one hundred and twenty five patients with primary liver cancer surviving more than five years.
Neoplasms
Analytical Platforms for the Determination of Phospholipid Turnover in Breast Cancer Tissue: Role of Phospholipase Activity in Breast Cancer Development.
Neoplasms
Antiangiogenic Therapy for Primary Liver Cancer: Correlation of Changes in Dynamic Contrast-Enhanced Magnetic Resonance Imaging with Tissue Hypoxia Markers and Clinical Response.
Neoplasms
Anticarcinogenic effect of bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione a curcumin analog on DMH-induced colon cancer model.
Neoplasms
Anticipatory estrogen activation of the unfolded protein response is linked to cell proliferation and poor survival in estrogen receptor ?-positive breast cancer.
Neoplasms
Apigenin inhibits NF-?B and snail signaling, EMT and metastasis in human hepatocellular carcinoma.
Neoplasms
Arachidonic acid is involved in the regulation of hCG induced steroidogenesis in rat Leydig cells.
Neoplasms
AS-1411, a guanosine-rich oligonucleotide aptamer targeting nucleolin for the potential treatment of cancer, including acute myeloid leukemia.
Neoplasms
Association between the expression of HIF-1? and VEGF and prognostic implications in primary liver cancer.
Neoplasms
Association of activated G?q to the tumor suppressor Fhit is enhanced by phospholipase C?.
Neoplasms
Attachment of human placental-type alkaline phosphatase via phosphatidylinositol to syncytiotrophoblast and tumour cell plasma membranes.
Neoplasms
Augmentation of carcinoembryonic antigen release from intact, viable tumor cells by a factor in human serum.
Neoplasms
Biosynthesis of carcinoembryonic antigen (CEA) gene family members expressed in human tumor cell lines: evidence for cleavage of the glycosyl phosphatidyl inositol (GPI) anchor by GPI-PLC and GPI-PLD.
Neoplasms
Blockade of TRPC6 channels induced G2/M phase arrest and suppressed growth in human gastric cancer cells.
Neoplasms
Ca2+ and partly GTP gamma S-dependent particulate phospholipase C hydrolyzing phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate is inhibited by diacyl(acyl-acetyl) glycerols.
Neoplasms
Candidate driver genes involved in genome maintenance and DNA repair in Sézary syndrome.
Neoplasms
CD34+ peripheral blood progenitor cell and monocyte derived dendritic cells: a comparative analysis.
Neoplasms
Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors.
Neoplasms
Changes in serum levels of Forssman-like antibody in patients with gastric cancer.
Neoplasms
Changes of phosphatidylcholine-specific phospholipase C in hepatocarcinogenesis and in the proliferation and differentiation of rat liver cancer cells.
Neoplasms
Characterization of a novel tumor-suppressor gene PLC delta 1 at 3p22 in esophageal squamous cell carcinoma.
Neoplasms
Characterization of phosphatidylinositol phospholipase C activity in human melanoma.
Neoplasms
Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.
Neoplasms
Clear cell renal cell carcinoma with Paneth-like cells: Clinicopathologic, morphologic, immunohistochemical, ultrastructural, and molecular analysis of 13 cases.
Neoplasms
Clinical and Radiological Discrimination of Solitary Pulmonary Lesions in Colorectal Cancer Patients.
Neoplasms
Clinical evaluation of cryosurgery in the treatment of primary liver cancer. Report of 60 cases.
Neoplasms
Clinical outcome in pleomorphic lobular carcinoma: a case-control study with comparison to classic invasive lobular carcinoma.
Neoplasms
Clinicopathological features of intraoperative pleural lavage cytology for non-small cell lung cancer.
Neoplasms
Combination chemotherapy with Clostridium perfringens phospholipase C and cytosine antimetabolites: complementary inhibition directed at membrane lipids.
Neoplasms
Combined Hepatocellular-Cholangiocarcinoma with Fever of Unknown Origin: A Case Report and Review of Literature.
Neoplasms
Combined hepatocellular-cholangiocarcinoma: An analysis of clinicopathological characteristics after surgery.
Neoplasms
Comparative evaluation of in vitro cytotoxic effects among parent abietyl alcohol and novel fatty acid ester derivatives against MCF7 and hepatocellular carcinoma cell lines.
Neoplasms
Comparative studies on the immunosuppressive effect among 5'-deoxy-5-fluorouridine, ftorafur, and 5-fluorouracil.
Neoplasms
Comparison of CD28-B7.1 and B7.2 functional interaction in resting human T cells: phosphatidylinositol 3-kinase association to CD28 and cytokine production.
Neoplasms
Construction of recombinant adenovirus Ad-rat PLCg2-shRNA and successful suppression of PLCg2 expression in BRL-3A cells.
Neoplasms
Contribution of Hepatitis B, C Virus to Liver Cancer in China North Areas: Experience from Chinese National Cancer Center.
Neoplasms
Correlation between expression levels of PTEN and p53 genes and the clinical features of HBsAg-positive liver cancer.
Neoplasms
Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta-analysis.
Neoplasms
Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester.
Neoplasms
Data Mining and Systems Pharmacology to Elucidate Effectiveness and Mechanisms of Chinese Medicine in Treating Primary Liver Cancer.
Neoplasms
Decreased adenylyl cyclase and cAMP-dependent protein kinase activities inhibit the cytotoxic function of human natural killer cells.
Neoplasms
Designing a light-activated recombinant alpha hemolysin for colorectal cancer targeting.
Neoplasms
Detection of neutral active phosphatidylcholine-specific phospholipase C in Friend leukemia cells before and after erythroid differentiation.
Neoplasms
Detection of phosphatidylcholine-specific phospholipase C in NIH-3T3 fibroblasts and their H-ras transformants: NMR and immunochemical studies.
Neoplasms
Detection of polypeptides associated with the histopathological differentiation of primary lung carcinoma.
Neoplasms
Developing liver organoids from induced pluripotent stem cells (iPSCs): An alternative source of organoid generation for liver cancer research.
Neoplasms
Development of 2-Morpholino-N-hydroxybenzamides as anti-proliferative PC-PLC inhibitors.
Neoplasms
Development of a liquid chromatography-mass spectrometry based enzyme activity assay for phosphatidylcholine-specific phospholipase C.
Neoplasms
Development, synthesis and biological investigation of a novel class of potent PC-PLC inhibitors.
Neoplasms
Diagnostic accuracy of primary liver cancer: implications for cancer registration.
Neoplasms
Diagnostic and prognostic value of mRNA expression of phospholipase C ? family genes in hepatitis B virus?associated hepatocellular carcinoma.
Neoplasms
Differential effects of diacylglycerols and 12-O-tetradecanoylphorbol-13-acetate on protein phosphorylation and cell proliferation of tumor promoter-dependent leukemia cell line A65T.
Neoplasms
Differentiation impairs low pH-induced Ca2+ signaling and ERK phosphorylation in granule precursor tumour cells.
Neoplasms
Direct evidence for phorbol ester-stimulated accumulation of diacylglycerol derived from phosphatidylcholine.
Neoplasms
Does pyogenic liver abscess increase the risk of delayed-onset primary liver cancer?: Evidence from a nationwide cohort study.
Neoplasms
Effect of membrane lipid alteration on the growth, phospholipase C activity and G protein of HT-29 tumor cells.
Neoplasms
Effect of Phospholipase C-gamma1 Overexpression on the Protein Level of Waf1, PCNA, and Cyclin B1 Following Ultraviolet C Irradiation.
Neoplasms
Effects of 12-O-tetradecanoylphorbol 13-acetate on glycerolipid metabolism in cultured myoblasts.
Neoplasms
Effects of carbocisteine on sialyl-Lewis x expression in an airway carcinoma cell line stimulated with tumor necrosis factor-alpha.
Neoplasms
Effects of HGF gene polymorphisms and protein expression on transhepatic arterial chemotherapeutic embolism efficacy and prognosis in patients with primary liver cancer.
Neoplasms
Effects of liver cirrhosis on portal vein embolization prior to right hepatectomy in patients with primary liver cancer.
Neoplasms
Effects of the Aidi Dripping Pills on immune functions of the tumor-bearing mouse.
Neoplasms
Efficacy of adjuvant chemotherapy for lung adenocarcinoma patients with positive pleural lavage cytology findings.
Neoplasms
Efficient Colonization and Therapy of Human Hepatocellular Carcinoma (HCC) Using the Oncolytic Vaccinia Virus Strain GLV-1h68.
Neoplasms
Enhanced antitumour effect of liposomal daunorubicin using antibody-phospholipase C conjugates or fusion protein.
Neoplasms
Epidemiological analysis of primary liver cancer in the early 21st century in Guangxi province of China.
Neoplasms
Eugenol reduces the expression of virulence-related exoproteins in Staphylococcus aureus.
Neoplasms
Evidence that phospholipase C is involved in the antitumour action of NSC768313, a new thieno[2,3-b]pyridine derivative.
Neoplasms
Exclusion of the phosphatidylinositol-specific phospholipase C beta 3 (PLC beta 3) gene as candidate for the multiple endocrine neoplasia type 1 (MEN 1) gene.
Neoplasms
Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells.
Neoplasms
Expression of a Nagao-type, phosphatidylinositol-glycan anchored alkaline phosphatase in human choriocarcinomas.
Neoplasms
Expression of MUC1 and its significance in hepatocellular and cholangiocarcinoma tissue.
Neoplasms
Expression of phospholipase C isozymes in human breast cancer and their clinical significance.
Neoplasms
Expression of phospholipases gamma 1, beta 1, and delta 1 in primary human colon carcinomas and colon carcinoma cell lines.
Neoplasms
Expressions of Lewis antigens in human non-small cell pulmonary cancer and primary liver cancer with different pathological conditions.
Neoplasms
Fc epsilon R1-mediated tyrosine phosphorylation of multiple proteins, including phospholipase C gamma 1 and the receptor beta gamma 2 complex, in RBL-2H3 rat basophilic leukemia cells.
Neoplasms
FGFR1 is critical for Rbl2 loss-driven tumor development and requires PLCG1 activation for continued growth of small cell lung cancer.
Neoplasms
Fine needle aspiration cytology of pleomorphic lobular carcinoma of the breast. Duct carcinoma as a diagnostic pitfall.
Neoplasms
Fluorodeoxyglucose Uptake in Advanced Non-small Cell Lung Cancer With and Without Pulmonary Lymphangitic Carcinomatosis.
Neoplasms
Fluorogenic XY-69 in Lipid Vesicles for Measuring Activity of Phospholipase C Isozymes.
Neoplasms
Frequency and characteristics of melanomas missed at a pigmented lesion clinic: a registry-based study.
Neoplasms
Function of the p55 tumor necrosis factor receptor "death domain" mediated by phosphatidylcholine-specific phospholipase C.
Neoplasms
Functional Genomic Complexity Defines Intratumor Heterogeneity and Tumor Aggressiveness in Liver Cancer.
Neoplasms
Functional roles of PC-PLC and Cdc20 in the cell cycle, proliferation, and apoptosis.
Neoplasms
Genomic imbalances pinpoint potential oncogenes and tumor suppressors in Wilms tumors.
Neoplasms
GnRH analogs stimulate phospholipase C activity in mammary tumor membranes: modulation by GTP.
Neoplasms
Gonadotropin-releasing hormone signaling pathways in an experimental ovarian tumor.
Neoplasms
Grape and wine polyphenols down-regulate the expression of signal transduction genes and inhibit the growth of estrogen receptor-negative MDA-MB231 tumors in nu/nu mouse xenografts.
Neoplasms
Guanine nucleotides activate cytosolic phospholipase C of ascites tumour cells stimulated by 1-oleoyl-2-acetyl-sn-glycerol.
Neoplasms
Hepatocellular carcinoma and other primary liver cancers in hepatitis C patients in Sweden - a low endemic country.
Neoplasms
Hereditary Trichilemmal Cysts are Caused by Two Hits to the Same Copy of the Phospholipase C Delta 1 Gene (PLCD1).
Neoplasms
High expression of DLC family proteins predicts better prognosis and inhibits tumor progression in NSCLC.
Neoplasms
Human pheochromocytomas express orexin receptor type 2 gene and display an in vitro secretory response to orexins A and B.
Neoplasms
Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.
Neoplasms
Human-derived osteoblast-like cells and pericyte-like cells induce distinct metastatic phenotypes in primary breast cancer cells.
Neoplasms
Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells.
Neoplasms
Hydrolysis of inositol phospholipids precedes cellular proliferation in asbestos-stimulated tracheobronchial epithelial cells.
Neoplasms
Hyperparathyroidism of multiple endocrine neoplasia type 1: candidate gene and parathyroid calcium sensing protein expression.
Neoplasms
Hypofractionated three-dimensional conformal radiation therapy for primary liver carcinoma.
Neoplasms
Identification of Cancer Stem Cell Subpopulations of CD34(+) PLC/PRF/5 That Result in Three Types of Human Liver Carcinomas.
Neoplasms
Identification of clinical trait-related lncRNA and mRNA biomarkers with weighted gene co-expression network analysis as useful tool for personalized medicine in ovarian cancer.
Neoplasms
Identification of key genes and pathways associated with classical Hodgkin lymphoma by bioinformatics analysis.
Neoplasms
Immunomorphology and molecular biology of mixed primary liver cancers: is nestin a marker of intermediate-cell carcinoma?
Neoplasms
Impact of three-dimensional visualization technology on surgical strategies in complex hepatic cancer.
Neoplasms
In vivo immunological activity of carboxymethylated-sulfated (1?3)-?-D-glucan from sclerotium of Poria cocos.
Neoplasms
Incidence of primary liver cancer and aetiological aspects: a study of a defined population from a low-endemicity area.
Neoplasms
Increased neuronal survival in the brainstem during liver injury: role of ?-aminobutyric acid and serotonin chitosan nanoparticles.
Neoplasms
Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol.
Neoplasms
Inhibition of Phosphatidylcholine-Specific Phospholipase C Interferes with Proliferation and Survival of Tumor Initiating Cells in Squamous Cell Carcinoma.
Neoplasms
Inhibition of phospholipase C delta by hexadecylphosphorylcholine and lysophospholipids with antitumor activity.
Neoplasms
Interaction between protein kinase C-dependent and G protein-dependent pathways in the regulation of natural killer cell granule exocytosis.
Neoplasms
Interaction of phospholipase C with liposome: A conformation transition of the enzyme is critical and specific to liposome composition for burst hydrolysis and fusion in concert.
Neoplasms
Intracellular trafficking and cellular uptake mechanism of mPEG-PLGA-PLL and mPEG-PLGA-PLL-Gal nanoparticles for targeted delivery to hepatomas.
Neoplasms
Intrapleural chemotherapy improves the survival of non-small cell lung cancer patients with positive pleural lavage cytology.
Neoplasms
Intrapulmonary expression of scavenger receptor and CD14 and their relation to local inflammatory responses to endotoxemia in mice.
Neoplasms
Investigation of Phospholipase C?1 Interaction with SLP76 Using Molecular Modeling Methods for Identifying Novel Inhibitors.
Neoplasms
kappa-Opioid receptor potentiates apoptosis via a phospholipase C pathway in the CNE2 human epithelial tumor cell line.
Neoplasms
Levan enhanced the NF-?B suppression activity of an oral nano PLGA-curcumin formulation in breast cancer treatment.
Neoplasms
Liver Cancer in Viet Nam: Risk Estimates of Viral Infections and Dioxin Exposure in the South and North Populations.
Neoplasms
Liver cirrhosis and liver cancer. A study of their relationship in 2563 autopsies.
Neoplasms
Long-term survivors after resection for primary liver cancer. Clinical analysis of 19 patients surviving more than ten years.
Neoplasms
Lymphoid Enhancer Factor 1 Contributes to Hepatocellular Carcinoma Progression Through Transcriptional Regulation of Epithelial-Mesenchymal Transition Regulators and Stemness Genes.
Neoplasms
Measurements of cancer extent in a conservatively treated prostate cancer biopsy cohort.
Neoplasms
Micrometastasis in surrounding liver and the minimal length of resection margin of primary liver cancer.
Neoplasms
Molecular characterization and significance for prognosis of free gastric cancer cells in the peritoneal cavity.
Neoplasms
Molecular mechanisms of platelet activation and aggregation induced by breast cancer cells.
Neoplasms
Molecular mechanisms of triggering, amplifying and targeting RANK signaling in osteoclasts.
Neoplasms
Molecular profiling pleomorphic lobular carcinomas of the breast: evidence for a common molecular genetic pathway with classic lobular carcinomas.
Neoplasms
Mucins: the Old, the New and the Promising Factors in Hepatobiliary Carcinogenesis.
Neoplasms
Multi-omics study revealing the complexity and spatial heterogeneity of tumor-infiltrating lymphocytes in primary liver carcinoma.
Neoplasms
N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling.
Neoplasms
Nanodelivery of triamcinolone acetonide with PLGA-chitosan nanoparticles for the treatment of ocular inflammation.
Neoplasms
Neuropilin-1 promotes primary liver cancer progression by potentiating the activity of hepatic stellate cells.
Neoplasms
New insights into molecular diagnostic pathology of primary liver cancer: Advances and challenges.
Neoplasms
NIR Fluorescent Imaging and Photodynamic Therapy with a Novel Theranostic Phospholipid Probe for Triple-Negative Breast Cancer Cells.
Neoplasms
Nonprotecting Group Synthesis of a Phospholipase C Activatable Probe with an Azo-Free Quencher.
Neoplasms
Np63 (p40) Distribution Inside Lung Cancer: A Driver Biomarker Approach to Tumor Characterization.
Neoplasms
Oncogenic driver genes and tumor microenvironment determine the type of liver cancer.
Neoplasms
Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression.
Neoplasms
OXYGEN-STABLE HEMOLYSINS OF GROUP A STREPTOCCI. IV. STUDIES ON THE MECHANISM OF LYSIS BY CELL-BOUND HEMOLYSIN OF RED BLOOD CELLS AND EHRLICH ASCITES TUMOR CELLS.
Neoplasms
P-Cadherin (CDH3) is overexpressed in colorectal tumors and has potential as a serum marker for colorectal cancer monitoring.
Neoplasms
P2-purinergic receptor agonists inhibit the growth of androgen-independent prostate carcinoma cells.
Neoplasms
papG alleles among Escherichia coli strains causing urosepsis: associations with other bacterial characteristics and host compromise.
Neoplasms
PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR.
Neoplasms
Peritoneal lavage cytology and carcinoembryonic antigen determination in predicting peritoneal metastasis and prognosis of gastric cancer.
Neoplasms
Peritoneal wash cytology in gastric carcinoma. Prognostic significance and therapeutic consequences.
Neoplasms
Phase II study of troxacitabine (BCH-4556) in patients with advanced and/or metastatic renal cell carcinoma: a trial of the National Cancer Institute of Canada-Clinical Trials Group.
Neoplasms
Phorbol myristate acetate inhibits phosphoinositol lipid-specific phospholipase C activity via protein kinase C activation in conditions inducing differentiation in HL-60 cells.
Neoplasms
Phosphatidic acid mobilized by phospholipase D is involved in the phorbol 12-myristate 13-acetate-induced G2 delay of A431 cells.
Neoplasms
Phosphatidylcholine hydrolysis activates NF-kappa B and increases human immunodeficiency virus replication in human monocytes and T lymphocytes.
Neoplasms
Phosphatidylcholine-specific phospholipase C activation in epithelial ovarian cancer cells.
Neoplasms
Phosphatidylcholine-specific phospholipase C inhibition down- regulates CXCR4 expression and interferes with proliferation, invasion and glycolysis in glioma cells.
Neoplasms
Phosphatidylcholine-specific phospholipase C inhibition reduces HER2-overexpression, cell proliferation and in vivo tumor growth in a highly tumorigenic ovarian cancer model.
Neoplasms
Phosphatidylcholine-specific phospholipase C regulates glutamate-induced nerve cell death.
Neoplasms
Phosphoinositide specific phospholipase C?1 inhibition-driven autophagy caused cell death in human lung adenocarcinoma A549 cells in vivo and in vitro.
Neoplasms
Phosphoinositide-Dependent Signaling in Cancer: A Focus on Phospholipase C Isozymes.
Neoplasms
Phospholipase C activates protein kinase C and induces monocytic differentiation of HL-60 cells.
Neoplasms
Phospholipase C activation in the cytotoxic response of human natural killer cells requires protein-tyrosine kinase activity.
Neoplasms
Phospholipase C activity in normal rat mammary tissues and in DMBA-induced rat mammary tumors.
Neoplasms
Phospholipase C delta 1 is a novel 3p22.3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric cancer.
Neoplasms
Phospholipase C families: Common themes and versatility in physiology and pathology.
Neoplasms
Phospholipase C from human melanoma: purification and characterization of a phosphatidylinositol-selective enzyme.
Neoplasms
Phospholipase C mimics tumor promoter-induced chemiluminescence in murine epidermal cells.
Neoplasms
Phospholipase C-induced monocytic differentiation in a human monocytic leukemia cell line THP-1.
Neoplasms
Phospholipase C?1 represses colorectal cancer growth by inhibiting the Wnt/?-catenin signaling axis.
Neoplasms
Pinellia pedatisecta agglutinin-based lectin blot analysis distinguishes between glycosylation patterns in various cancer cell lines.
Neoplasms
Platelet count and survival in patients with colorectal cancer--a preliminary study.
Neoplasms
PLC gamma contributes to metastasis of in situ-occurring mammary and prostate tumors.
Neoplasms
PLC-beta2 is highly expressed in breast cancer and is associated with a poor outcome: a study on tissue microarrays.
Neoplasms
PLC? regulates prostate cancer mitochondrial oxidative metabolism and migration via upregulation of Twist1.
Neoplasms
PLC?1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia.
Neoplasms
PLCB4 upregulation is associated with unfavorable prognosis in pediatric acute myeloid leukemia.
Neoplasms
PLCD1 Suppressed Cellular Proliferation, Invasion, and Migration via Inhibition of Wnt/?-Catenin Signaling Pathway in Esophageal Squamous Cell Carcinoma.
Neoplasms
PLCD3, a flotillin2-interacting protein, is involved in proliferation, migration and invasion of nasopharyngeal carcinoma cells.
Neoplasms
PLCG2 as a potential indicator of tumor microenvironment remodeling in soft tissue sarcoma.
Neoplasms
Pleomorphic lobular carcinoma in pleural fluid: diagnostic pitfall for atypical mesothelial cells.
Neoplasms
Pleomorphic lobular carcinoma of the breast: its cell kinetics, expression of oncogenes and tumour suppressor genes compared with invasive ductal carcinomas and classical infiltrating lobular carcinomas.
Neoplasms
Pleomorphic lobular carcinoma: morphology, immunohistochemistry, and molecular analysis.
Neoplasms
Pleural invasion, epidermal growth factor receptor mutation and carcinoembryonic antigen level affect pleural lavage cytology-positive status in non-small-cell lung cancer.
Neoplasms
Pore formation by the Escherichia coli alpha-hemolysin: role for mediator release from human inflammatory cells.
Neoplasms
Positive Intraoperative Peritoneal Lavage Cytology is a Negative Prognostic Factor in Pancreatic Ductal Adenocarcinoma: A Retrospective Single-Center Study.
Neoplasms
Positive pre-resection pleural lavage cytology is associated with increased risk of lung cancer recurrence in patients undergoing surgical resection: a meta-analysis of 4450 patients.
Neoplasms
Post-endoplasmic reticulum rescue of unstable MHC class I requires proprotein convertase PC7.
Neoplasms
Potassium channel-blockers as therapeutic agents to interfere with bone resorption of periodontal disease.
Neoplasms
Practice guidelines for the pathological diagnosis of primary liver cancer: 2015 update.
Neoplasms
Pre-treatment levels of C-reactive protein and squamous cell carcinoma antigen for predicting the aggressiveness of pharyngolaryngeal carcinoma.
Neoplasms
Primary liver cancer in the UK: Incidence, incidence-based mortality, and survival by subtype, sex, and nation.
Neoplasms
Primary liver cancer incidence-rates related to hepatitis-C virus infection: a correlational study in Osaka, Japan.
Neoplasms
Prognosis of non-small-cell lung cancer patients with positive pleural lavage cytology.
Neoplasms
Prognostic value of intraoperative pleural lavage cytology for lung cancer without carcinomatous pleuritis: importance in patients with early stage disease during long-term follow-up.
Neoplasms
Prognostic Value of Pleural Lavage Cytology in Patients with Lung Cancer Resection: An Updated Meta-Analysis.
Neoplasms
Promotion of benign hyperplastic lesions in hamster cheek pouch by membrane labilizing agents and calcium ion: evidence that intracellular calcium-induced release from growth control is an obligatory preliminary stage of tumor promotion.
Neoplasms
Protective potential of miR-146a-5p and its underlying molecular mechanism in diverse cancers: a comprehensive meta-analysis and bioinformatics analysis.
Neoplasms
Protein kinase C and intracellular calcium are involved in follicle-stimulating hormone-mediated meiotic resumption of cumulus cell-enclosed porcine oocytes in hypoxanthine-supplemented medium.
Neoplasms
Protein kinases A and C positively regulate G protein-dependent activation of phosphatidylinositol-specific phospholipase C by tumor necrosis factor-alpha in MC3T3-E1 osteoblasts.
Neoplasms
Pseudomonas aeruginosa pyocyanin modulates mucin glycosylation with sialyl-Lewis(x) to increase binding to airway epithelial cells.
Neoplasms
Pulmonary inflammation induced by Pseudomonas aeruginosa lipopolysaccharide, phospholipase C, and exotoxin A: role of interferon regulatory factor 1.
Neoplasms
Pulmonary lymphangitic carcinomatosis from an oropharyngeal squamous cell carcinoma: a case report.
Neoplasms
Pulmonary lymphangitic carcinomatosis from head and neck squamous cell carcinoma.
Neoplasms
Pulmonary lymphangitic carcinomatosis: diagnostic performance of HRCT and 18F-FDG-PET/CT in correlation to clinical pathologic outcome.
Neoplasms
Pulmonary lymphangitis carcinomatosis: systematic review and meta-analysis of case reports, 1970-2018.
Neoplasms
Radiofrequency ablation combined with transarterial chemoembolization for unresectable primary liver cancer.
Neoplasms
Recent advances in understanding the molecular role of phosphoinositide-specific phospholipase C gamma 1 as an emerging onco-driver and novel therapeutic target in human carcinogenesis.
Neoplasms
Recurrence pattern and rapid intraoperative detection of carcinoembryonic antigen (CEA) mRNA in pleural lavage in patients with non-small cell lung cancer (NSCLC).
Neoplasms
Reduced Aflatoxin Exposure Presages Decline in Liver Cancer Mortality in an Endemic Region of China.
Neoplasms
Relevance of Intraoperative Pleural Lavage Cytology and Histologic Subtype in Lung Adenocarcinoma.
Neoplasms
Role of urokinase plasminogen activator receptor in thrombospondin 1-mediated tumor cell invasion.
Neoplasms
Rural-urban, sex variations, and time trend of primary liver cancer incidence in China, 1988-2005.
Neoplasms
Secondary Somatic Mutations in G-Protein-Related Pathways and Mutation Signatures in Uveal Melanoma.
Neoplasms
Selective inhibition of beta(2)-adrenergic receptor-mediated cAMP generation by activation of the P2Y(2) receptor in mouse pineal gland tumor cells.
Neoplasms
Serotonin as a major serum factor inducing the phospholipase C-mediated hydrolysis of phosphoinositides in normal rat kidney cells.
Neoplasms
Short Stat5-interacting peptide derived from phospholipase C-?3 inhibits hematopoietic cell proliferation and myeloid differentiation.
Neoplasms
Similar effects of phospholipase C and phorbol ester tumor promoters on primary mouse epidermal cells.
Neoplasms
Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo.
Neoplasms
Solitary Pulmonary Lesion in Patients with History of Malignancy: Primary Lung Cancer or Metastatic Cancer?
Neoplasms
Spontaneous and iatrogenic spreading of liver-derived cells into peripheral blood of patients with primary liver cancer.
Neoplasms
Staphylococcus Aureus-hemolysin A Disrupts Cell-matrix Adhesions in Human Airway Epithelial Cells.
Neoplasms
Status of pleural lavage cytology in cases of pulmonary metastasis: a single-institution retrospective study.
Neoplasms
Structure-activity-dependent regulation of cell communication by perfluorinated fatty acids using in vivo and in vitro model systems.
Neoplasms
Subinhibitory concentrations of thymol reduce enterotoxins A and B and alpha-hemolysin production in Staphylococcus aureus isolates.
Neoplasms
Suppression of proximal T cell receptor signaling and lytic function in CD8+ tumor-infiltrating T cells.
Neoplasms
Suppression of the neoplastic phenotype by transfection of phospholipase C beta 3 to neuroendocrine tumor cells.
Neoplasms
Synergism among oxidants, proteinases, phospholipases, microbial hemolysins, cationic proteins, and cytokines.
Neoplasms
Synthesis of fluorescent gold nanodot-liposome hybrids for detection of phospholipase C and its inhibitor.
Neoplasms
TA-CIN, a vaccine incorporating a recombinant HPV fusion protein (HPV16 L2E6E7) for the potential treatment of HPV16-associated genital diseases.
Neoplasms
Talin-1 correlates with reduced invasion and migration in human hepatocellular carcinoma cells.
Neoplasms
Targeted massively parallel sequencing of angiosarcomas reveals frequent activation of the mitogen activated protein kinase pathway.
Neoplasms
Temporal changes in liver cancer incidence rates in Japan: accounting for death certificate inaccuracies and improving diagnostic techniques.
Neoplasms
The ability of rat transplantable lymphosarcoma cells to synthesize immunoglobulins.
Neoplasms
The association between fasting blood glucose and the risk of primary liver cancer in Chinese males: a population-based prospective study.
Neoplasms
The association between individual metabolic syndrome components, primary liver cancer and cirrhosis: A study in the Swedish AMORIS cohort.
Neoplasms
The Availability of Pre- and Intraoperative Evaluation of a Solitary Pulmonary Nodule in Breast Cancer Patients.
Neoplasms
The cancer mortality and incidence experience of workers at British Nuclear Fuels plc, 1946-2005.
Neoplasms
The Effects of a Novel MEK Inhibitor PD184161 on MEK-ERK Signaling and Growth in Human Liver Cancer.
Neoplasms
The effects of bile acids on phospholipase C activity in extracts of normal human colon mucosa and primary colon tumors.
Neoplasms
The influence of hyaluronan-CD44 interaction on topoisomerase II activity and etoposide cytotoxicity in head and neck cancer.
Neoplasms
The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity.
Neoplasms
The mortality and cancer morbidity experience of employees at the Chapelcross plant of British Nuclear Fuels plc, 1955-95.
Neoplasms
The novel phospholipase C activator, m-3M3FBS, induces apoptosis in tumor cells through caspase activation, down-regulation of XIAP and intracellular calcium signaling.
Neoplasms
The phospholipase C beta 3 gene located in the MEN1 region shows loss of expression in endocrine tumours.
Neoplasms
The release of Hsp70 from A431 carcinoma cells is mediated by secretory-like granules.
Neoplasms
The UK Government two-week rule and its impact on melanoma prognosis: an evidence-based study.
Neoplasms
The underreporting of hepatocellular carcinoma to the Cancer Register and a log-linear model to estimate a more correct incidence.
Neoplasms
Thrombospondin-1 up-regulates tumor cell invasion through the urokinase plasminogen activator receptor in head and neck cancer cells.
Neoplasms
Thyroid-stimulating hormone activates phospholipase C in normal and neoplastic thyroid tissue.
Neoplasms
Thyrotrophin-releasing hormone stimulates polyphosphoinositide metabolism in the frog neurointermediate lobe.
Neoplasms
Toxinogenicity and markers of pathogenicity of Pseudomonas aeruginosa strains isolated from patients with tumor diseases.
Neoplasms
Tumor necrosis factor induces necrosis of human carcinoma xenografts in the presence of tricyclodecan-9-yl-xanthogenate and lauric acid.
Neoplasms
Tumor necrosis factor induces rapid production of 1'2'diacylglycerol by a phosphatidylcholine-specific phospholipase C.
Neoplasms
Tumor necrosis factor-alpha autoregulates interleukin-6 synthesis via activation of protein kinase C. Function of sphingosine 1-phosphate and phosphatidylcholine-specific phospholipase C.
Neoplasms
Tumor necrosis factor-alpha stimulates phosphatidylinositol breakdown by phospholipase C to coordinately increase the levels of diacylglycerol, free arachidonic acid and prostaglandins in an osteoblast (MC3T3-E1) cell line.
Neoplasms
Tumor promoting properties of a cigarette smoke prevalent polycyclic aromatic hydrocarbon as indicated by the inhibition of gap junctional intercellular communication via phosphatidylcholine-specific phospholipase C.
Neoplasms
Tumor/serum ratios of alphafetoprotein and radioimmunolocalization of primary liver cancer.
Neoplasms
Two distinct P2 purinergic receptors, P2Y and P2U, are coupled to phospholipase C in mouse pineal gland tumor cells.
Neoplasms
Up-regulated expression of phospholipase C, ?1 is associated with tumor cell proliferation and poor prognosis in hepatocellular carcinoma.
Neoplasms
Use of a recombinant Salmonella enterica serovar Typhimurium strain expressing C-Raf for protection against C-Raf induced lung adenoma in mice.
Neoplasms
Visceral pleura invasion and pleural lavage tumor cytology by lung cancer: a prospective appraisal.
Neoplasms
When is curative gastrectomy justified for gastric cancer with positive peritoneal lavage cytology but negative macroscopic peritoneal implant?
Neoplasms
[A thirty-one year prospective follow-up program on the HBsAg carrier state and primary liver cancer in Qidong, China.]
Neoplasms
[Cisplatin (CDDP) microcapsules in transcatheter hepatic arterial chemoembolization of primary liver cancer]
Neoplasms
[Clinical implications of spontaneous and iatrogenic dissemination of tumor cells in patients with primary liver cancer]
Neoplasms
[Clinicopathologic characteristics of primary liver cancer in patients younger than 35 years]
Neoplasms
[Dendritic cell vaccine modified by murine mAFP gene enhances immunoprotective effect on liver carcinogenesis and tumor development in mice]
Neoplasms
[Establishment and gene expression analysis of drug-resistant cell lines in hepatocellular carcinoma induced by sorafenib].
Neoplasms
[Evaluation of the results of fine-needle aspiration liver biopsies and the complications in 2528 cases.]
Neoplasms
[Expression of hepatocyte growth factor, transcription factor SP1, vascular endothelial growth factor and CD34 in serosa-infiltrative gastric cancer and their relations with defluxion of gastric cancercell and prognosis]
Neoplasms
[Longitudinal study of aflatoxin exposure in the development of primary liver cancer in patients with chronic hepatitis].
Neoplasms
[Molecular markers and mechanisms for stemness maintenance of liver cancer stem cells: a review].
Neoplasms
[Primary carcinoma of the liver and hepatitis C virus in Italy. A prospective study in patients with cirrhosis]
Neoplasms
[Prognosis of liver cirrhosis: results of a 14-year-long clinical follow-up study]
Neoplasms
[Prospective study of liver parenchyma volume in hepatectomy of primary liver cancer]
Neoplasms
[Quantitative study on tongue color in primary liver cancer patients by analysis system for comprehensive information of tongue diagnosis]
Neoplasms
[Radiotherapy in surgical and nonsurgical patients. Therapy expectations, quality of life and physician assessment]
Neoplasms
[Synergy and attenuation of cyclophosphamidum (CTX) activities by abalone polysaccharide]
Neoplasms
[The promoting research of phospholipase C epsilon-1 on nasal Th2 cell polarization].
Neoplasms
[Treatment of benign tumors in thoracic spinal canal by modified replanting posterior ligament complex applying piezoelectric osteotomy].
Neoplasms, Squamous Cell
Solitary Pulmonary Lesion in Patients with History of Malignancy: Primary Lung Cancer or Metastatic Cancer?
Neoplastic Cells, Circulating
Spontaneous and iatrogenic spreading of liver-derived cells into peripheral blood of patients with primary liver cancer.
Neoplastic Cells, Circulating
[Clinical implications of spontaneous and iatrogenic dissemination of tumor cells in patients with primary liver cancer]
Nephrosis
Auxiliary genetic analysis in a Chinese adolescent NPH family by single nucleotide polymorphism screening.
Nephrotic Syndrome
Advillin acts upstream of phospholipase C ?1 in steroid-resistant nephrotic syndrome.
Nephrotic Syndrome
HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome.
Nephrotic Syndrome
Whole exome sequencing identification of a novel insertion mutation in the phospholipase C ??1 gene in a family with steroid resistant inherited nephrotic syndrome.
Nephrotic Syndrome
[The promoting research of phospholipase C epsilon-1 on nasal Th2 cell polarization].
Nervous System Diseases
The association of pathological laughing and crying and cognitive impairment in multiple sclerosis.
Neuralgia
Indantadol, a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain.
Neuralgia
Phospholipase C{beta}3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain.
Neuralgia
The dopamine D1-D2DR complex in the rat spinal cord promotes neuropathic pain by increasing neuronal excitability after chronic constriction injury.
Neuroblastoma
A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase.
Neuroblastoma
Activation of phospholipase C in SH-SY5Y neuroblastoma cells by potassium-induced calcium entry.
Neuroblastoma
Activation of phospholipase C increases intramembrane electric fields in N1E-115 neuroblastoma cells.
Neuroblastoma
Cu-Zn superoxide dismutase activates muscarinic acetylcholine M1 receptor pathway in neuroblastoma cells.
Neuroblastoma
Ethanol-induced alteration in activities of cerebral phosphatidylinositol 4,5-biphosphate-specific and cytosolic phospholipase C in the brain: analysis using NG 108-15 cells and brains from ethanol-inhaled mice.
Neuroblastoma
Evaluation of ethanol effects on PLC signal transduction pathways using cell lines of neuronal origin.
Neuroblastoma
Heterogeneity of nucleotide receptors in NG108-15 neuroblastoma and C6 glioma cells for mediating phosphoinositide turnover.
Neuroblastoma
Inhibition of bradykinin-induced cytosolic Ca2+ elevation by muscarinic stimulation without attenuation of inositol 1,4,5-trisphosphate production in human neuroblastoma SK-N-BE(2)C cells.
Neuroblastoma
Inositol trisphosphate/Ca2+ as messengers of bradykinin B2 and muscarinic acetylcholine m1-m4 receptors in neuroblastoma-derived hybrid cells.
Neuroblastoma
Mu-opioids activate phospholipase C in SH-SY5Y human neuroblastoma cells via calcium-channel opening.
Neuroblastoma
Muscarine enhances soluble amyloid precursor protein secretion in human neuroblastoma SH-SY5Y by a pathway dependent on protein kinase C(alpha), src-tyrosine kinase and extracellular signal-regulated kinase but not phospholipase C.
Neuroblastoma
Muscarinic receptor regulation of cytoplasmic Ca2+ concentrations in human SK-N-SH neuroblastoma cells: Ca2+ requirements for phospholipase C activation.
Neuroblastoma
Pharmacological characterisation of pyrimidinoceptor responses in NG108-15 cells.
Neuroblastoma
Phosphatidic acid as the biosynthetic precursor of the endocannabinoid 2-arachidonoylglycerol in intact mouse neuroblastoma cells stimulated with ionomycin.
Neuroblastoma
Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation.
Neuroblastoma
Phospholipase C-?1 is activated by intracellular Ca(2+) mobilization and enhances GPCRs/PLC/Ca(2+) signaling.
Neuroblastoma
Phospholipase D and phospholipase C in human cholinergic neuroblastoma (LA-N-2) cells: modulation by muscarinic agonists and protein kinase C.
Neuroblastoma
Production of diacylglycerol by exogenous phospholipase C stimulates CTP:phosphocholine cytidylyltransferase activity and phosphatidylcholine synthesis in human neuroblastoma cells.
Neuroblastoma
Receptor-linked early events induced by vasoactive intestinal contractor (VIC) on neuroblastoma and vascular smooth-muscle cells.
Neuroblastoma
Selective effects of acute and chronic ethanol exposure on neuropeptide and guanine nucleotide stimulated phospholipase C activity in intact N1E-115 neuroblastoma.
Neuroblastoma
Signaling and interplay mediated by phospholipases A2, C, and D in LA-N-1 cell nuclei.
Neuroblastoma
Stimulation of phosphatidic acid of calcium influx and cyclic GMP synthesis in neuroblastoma cells.
Neuroblastoma
Stimulation of phospholipase D activity in human neuroblastoma (LA-N-2) cells by activation of muscarinic acetylcholine receptors or by phorbol esters: relationship to phosphoinositide turnover.
Neuroblastoma
Suppression of phospholipase C blocks Gi-mediated inhibition of adenylyl cyclase activity.
Neuroblastoma
Synergistic activation of adenylyl cyclase is dependent upon phospholipase C-mediated processes in human neuroblastoma SK-N-BE(2)C cells.
Neuroblastoma
The effects of acute exposure to ethanol on neurotensin and guanine nucleotide-stimulation of phospholipase C activity in intact NIE-115 neuroblastoma cells.
Neurodegenerative Diseases
A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.
Neurodegenerative Diseases
ABI3 and PLCG2 missense variants as risk factors for neurodegenerative diseases in Caucasians and African Americans.
Neurodegenerative Diseases
Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischaemia in the rat hippocampus.
Neurodegenerative Diseases
Drosophila Niemann-Pick Type C-2 genes control sterol homeostasis and steroid biosynthesis: a model of human neurodegenerative disease.
Neurodegenerative Diseases
Natural Products in Drug Discovery and Development. 27-28 June 2005, London, UK.
Neuroendocrine Tumors
In situ RNA-RNA hybridisation of phospholipase C beta 3 shows lack of expression in neuroendocrine tumours.
Neuroendocrine Tumors
Suppression of the neoplastic phenotype by transfection of phospholipase C beta 3 to neuroendocrine tumor cells.
Neuroinflammatory Diseases
Reversal of a Treatment-Resistant, Depression-Related Brain State with the Kv7 Channel Opener Retigabine.
Neuroma
Highly permeable polylactide-caprolactone nerve guides enhance peripheral nerve regeneration through long gaps.
Newcastle Disease
The inactivation of Newcastle disease virus hemolysin by antiserum and high-energy electrons.
Niemann-Pick Disease, Type A
Deficiency of phospholipase C acting on phosphatidylglycerol in Niemann-Pick disease.
Niemann-Pick Disease, Type C
Functional analysis of Niemann-Pick disease type C family protein, NPC1a, in Drosophila melanogaster.
Niemann-Pick Diseases
Acidic phospholipases in cultured human fibroblasts: deficiency of phospholipase C in Niemann-Pick disease.
Niemann-Pick Diseases
Deficiency of phospholipase C acting on phosphatidylglycerol in Niemann-Pick disease.
Niemann-Pick Diseases
Deficiency of taurocholate-dependent phospholipase C acting on phosphatidylcholine in Niemann-Pick disease.
Niemann-Pick Diseases
Functional analysis of Niemann-Pick disease type C family protein, NPC1a, in Drosophila melanogaster.
Niemann-Pick Diseases
Phosphatidylcholine and 4-methylumbelliferyl phosphorylcholine hydrolysis by purified placental sphingomyelinase.
Non-alcoholic Fatty Liver Disease
Expanding the Liver Imaging Reporting and Data System (LI-RADS) v2018 diagnostic population: performance and reliability of LI-RADS for distinguishing hepatocellular carcinoma (HCC) from non-HCC primary liver carcinoma in patients who do not meet strict LI-RADS high-risk criteria.
Non-alcoholic Fatty Liver Disease
Global incidence trends in primary liver cancer by age at diagnosis, sex, region, and etiology, 1990-2017.
Non-alcoholic Fatty Liver Disease
International trends in primary liver cancer incidence from 1973 to 2007.
Non-alcoholic Fatty Liver Disease
Oncogenic driver genes and tumor microenvironment determine the type of liver cancer.
Obesity
G(q/11)? and G(s)? mediate distinct physiological responses to central melanocortins.
Obesity
Oral supplementation of propionyl-l-carnitine reduces body weight and hyperinsulinaemia in obese Zucker rats.
Obesity
The association between individual metabolic syndrome components, primary liver cancer and cirrhosis: A study in the Swedish AMORIS cohort.
Ocular Hypertension
Outcomes of Gel Stent Implantation for Glaucoma in Patients With Previous Corneal Graft Surgery: A Case Series.
Opportunistic Infections
Ceramidase enhances phospholipase C-induced hemolysis by Pseudomonas aeruginosa.
Osteitis
Enzyme-linked immunosorbent assay for detection of antibodies to Pseudomonas aeruginosa exoproteins.
Osteoarthritis
No Difference Between Posterolateral Corner Repair and Reconstruction With Concurrent ACL Surgery: Results From a Prospective Multicenter Cohort.
Osteoarthritis
Open Anatomic Reconstruction of the Posterolateral Corner: The Arciero Technique.
Osteoarthritis
Quantitative immunodetection of key elements of polyphosphoinositide signal transduction in osteoblasts from arthritic patients shows a direct correlation with cell proliferation.
Osteoarthritis
[Value of anti hemolysin and anti-gammahemolysin assays for the diagnosis of staphylococcal infections, particularly of osteoarthritis (author's transl)]
Osteolysis
Targeted inhibition of phospholipase C gamma 2 adapter function blocks osteoclastogenesis and protects from pathological osteolysis.
Osteomyelitis
Anti-staphylococcal gamma hemolysin antibodies in rabbits with staphylococcal osteomyelitis.
Osteoporosis
Analytical basis for the determination of the lacunar-canalicular permeability of bone using cyclic loading.
Osteoporosis
Changing serine-485 to alanine in the opossum parathyroid hormone (PTH)/PTH-related peptide receptor enhances PTH stimulation of phospholipase C in a stably transfected human kidney cell line: a useful model for PTH-analog screening?
Osteoporosis
Comparison of questionnaire and quantitative ultrasound techniques as screening tools for DXA.
Osteosarcoma
A novel phospholipase C inhibitor and phorbol esters reveal selective regulation of thrombin- and parathyroid hormone-stimulated signaling pathways in rat osteosarcoma cells.
Osteosarcoma
Calcitonin gene-related peptide (CGRP) increases intracellular free Ca2+ concentrations but not cyclic AMP formation in CGRP receptor-positive osteosarcoma cells (OHS-4).
Osteosarcoma
Characterization of phospholipase C activity of the plasma membrane and cytosol of an osteoblast-like cell line.
Osteosarcoma
CXCL13/CXCR5 Interaction Facilitates VCAM-1-Dependent Migration in Human Osteosarcoma.
Osteosarcoma
Dexamethasone increases G alpha q-11 expression and hormone-stimulated phospholipase C activity in UMR-106-01 cells.
Osteosarcoma
Effect of miconazole on intracellular Ca2+ levels and proliferation in human osteosarcoma cells.
Osteosarcoma
Ezrin-related Phosphoinositide pathway modifies RhoA and Rac1 in human osteosarcoma cell lines.
Osteosarcoma
Interleukin 1 alpha stimulates nuclear phospholipase C in human osteosarcoma SaOS-2 cells.
Osteosarcoma
Interleukin-1 alpha induces variations of the intranuclear amount of phosphatidylinositol 4,5-bisphosphate and phospholipase C beta 1 in human osteosarcoma Saos-2 cells.
Osteosarcoma
Mechanisms of regulation of G(11)alpha protein by dexamethasone in osteoblastic UMR 106-01 cells.
Osteosarcoma
Mechanosensitivity of human osteosarcoma cells and phospholipase C beta2 expression.
Osteosarcoma
Phosphatidylcholine-specific phospholipase C inhibitor, tricyclodecan-9-yl xanthogenate (D609), increases phospholipase D-mediated phosphatidylcholine hydrolysis in UMR-106 osteoblastic osteosarcoma cells.
Osteosarcoma
Phosphatidylinositol 3-kinase translocation to the nucleus is an early event in the interleukin-1 signalling mechanism in human osteosarcoma Saos-2 cells.
Osteosarcoma
Phosphoinositide signaling in nuclei of Friend cells: phospholipase C beta down-regulation is related to cell differentiation.
Osteosarcoma
Release of alkaline phosphatase from human osteosarcoma cells by phosphatidylinositol phospholipase C: effect of tunicamycin.
Osteosarcoma
Stimulation of femoral trabecular bone growth in ovariectomized rats by human parathyroid hormone (hPTH)-(1-30)NH(2).
Osteosarcoma
Sulfhydryl modification by 4,4'-dithiodipyridine induces calcium mobilization in human osteoblast-like cells.
Osteosarcoma
Thiol oxidation by 2,2'-dithiodipyridine induced calcium mobilization in MG63 human osteosarcoma cells.
Osteosarcoma
Thrombospondin-2 stimulates MMP-9 production and promotes osteosarcoma metastasis via the PLC, PKC, c-Src and NF-?B activation.
Osteosarcoma
U-73122 reduces the cell growth in cultured MG-63 ostesarcoma cell line involving Phosphoinositide-specific Phospholipases C.
Ovarian Neoplasms
Activation of Phosphatidylcholine-Specific Phospholipase C in Breast and Ovarian Cancer: Impact on MRS-Detected Choline Metabolic Profile and Perspectives for Targeted Therapy.
Ovarian Neoplasms
Calcium release from intracellular stores is involved in mitochondria depolarization after lowering extracellular pH in rat brain synaptosomes.
Ovarian Neoplasms
NIR Fluorescent Imaging and Photodynamic Therapy with a Novel Theranostic Phospholipid Probe for Triple-Negative Breast Cancer Cells.
Ovarian Neoplasms
Phosphatidylcholine-specific phospholipase C inhibition reduces HER2-overexpression, cell proliferation and in vivo tumor growth in a highly tumorigenic ovarian cancer model.
Ovarian Neoplasms
Role of TGF alpha stimulation of the ERK, PI3 kinase and PLC gamma pathways in ovarian cancer growth and migration.
Ovarian Neoplasms
Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation.
Pancreatic Neoplasms
Norepinephrine inhibits the migratory activity of pancreatic cancer cells.
Pancreatic Neoplasms
[Phospholipase C ?1 (PLCD1) inhibits the proliferation, invasion and migration of CAPAN-1 and BXPC-3 pancreatic cancer cells].
Pancreatitis
Phospholipids, acute pancreatitis, and the lungs: effect of lecithinase infusion on pulmonary surface activity in dogs.
Pancreatitis
The potential role of Clostridium perfringens alpha toxin in the pathogenesis of acute pancreatitis.
Pancreatitis
[Warning signals in acute abdominal disorders. Lactate is the best marker of mesenteric ischemia]
Pancreatitis, Chronic
Chronic pancreatitis is associated with increased concentrations of epidermal growth factor receptor, transforming growth factor alpha, and phospholipase C gamma.
Papilloma
Breast cancer cutaneous metastases mimicking Papilloma Cutis Lymphostatica. Biopsy to avoid pitfalls.
Paracoccidioidomycosis
Monocyte adherence to Paracoccidioides brasiliensis, zymosan-C3b and erythrocyte-hemolysin in patients with paracoccidioidomycosis.
Paralysis
Association of ABI3 and PLCG2 missense variants with disease risk and neuropathology in Lewy body disease and progressive supranuclear palsy.
Paralysis
Common Peroneal Nerve Palsy with Multiple-Ligament Knee Injury and Distal Avulsion of the Biceps Femoris Tendon.
Paralysis
Distal posterolateral corner injury in the setting of multiligament knee injury increases risk of common peroneal palsy.
Paralysis
The Pathoanatomy of Posterolateral Corner Ligamentous Disruption in Multiligament Knee Injuries Is Predictive of Peroneal Nerve Injury.
Paraneoplastic Syndromes
Paraneoplastic syndromes in primary liver-cell carcinoma: experience in Ibadan, Nigeria.
Parapsoriasis
[Ultrastructure of parapsoriasis lesions. Parapsoriasis en plaques and parakeratosis variegata as prelymphoma; differences from pityriasis lichenoides]
Parathyroid Neoplasms
Quantitative proteomics analysis of sporadic parathyroid adenoma tissue samples.
Paresis
Pathological laughter as prodromal manifestation of transient ischemic attacks--case report and brief review.
Parkinson Disease
Autophagy and innate immunity: Insights from invertebrate model organisms.
Parkinson Disease
D1-mGlu5 heteromers mediate noncanonical dopamine signaling in Parkinson's disease.
Pemphigus
Beyond steric hindrance: the role of adhesion signaling pathways in the pathogenesis of pemphigus.
Pemphigus
Ca2+ signalling is critical for autoantibody-induced blistering of human epidermis in pemphigus.
Pemphigus
Pemphigus IgG activates and translocates protein kinase C from the cytosol to the particulate/cytoskeleton fractions in human keratinocytes.
Pemphigus
Pemphigus IgG induces expression of urokinase plasminogen activator receptor on the cell surface of cultured keratinocytes.
Pemphigus
Pharmacologic evidence for involvement of phospholipase C in pemphigus IgG-induced inositol 1,4,5-trisphosphate generation, intracellular calcium increase, and plasminogen activator secretion in DJM-1 cells, a squamous cell carcinoma line.
Pemphigus
Phosphatidylcholine-specific phospholipase C, but not phospholipase D, is involved in pemphigus IgG-induced signal transduction.
Periodontal Diseases
Exocellular phospholipase C activity from a Propionibacterium acnes strain isolated from a periodontal pocket.
Periodontal Pocket
Cloning of two distinct hemolysin genes from Porphyromonas (Bacteroides) gingivalis in Escherichia coli.
Periodontal Pocket
Exocellular phospholipase C activity from a Propionibacterium acnes strain isolated from a periodontal pocket.
Periodontitis
Activation of Receptor Activator of Nuclear Factor-?B Ligand and Matrix Metalloproteinase Production in Periodontal Fibroblasts by Endothelin Signaling.
Periodontitis
Effects of tetracyclines on neutrophil, gingival, and salivary collagenases. A functional and western-blot assessment with special reference to their cellular sources in periodontal diseases.
Periodontitis
Modulation of host matrix metalloproteinases by bacterial virulence factors relevant in human periodontal diseases.
Periodontitis
The 46-kilodalton-hemolysin gene from Treponema denticola encodes a novel hemolysin homologous to aminotransferases.
Peripheral Arterial Disease
31Phosphorus magnetic resonance spectroscopy to evaluate medical therapy efficacy in peripheral arterial disease. A pilot study.
Peripheral Arterial Disease
Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders.
Peripheral Arterial Disease
Pharmacokinetics of propionyl-L-carnitine in humans: evidence for saturable tubular reabsorption.
Peripheral Arterial Disease
Pharmacological effects and clinical applications of propionyl-L-carnitine.
Periprosthetic Fractures
Femoral Periprosthetic Fracture in Osteoporotic Bone after a Total Knee Replacement: Treatment with Ilizarov External Fixation.
Peritonitis
Generation and testing of mutants of Enterococcus faecalis in a mouse peritonitis model.
Peritonitis
Inhibitory effects of propionyl-L-carnitine on plasma extravasation induced by irritants in rodents.
Peritonitis
Peritoneal leucocyte response to bacterial peritonitis in patients receiving peritoneal dialysis.
Peritonitis
Vaccination for prevention of CAPD associated staphylococcal infection: results of a prospective multicentre clinical trial.
Peritonitis
[Warning signals in acute abdominal disorders. Lactate is the best marker of mesenteric ischemia]
Persistent Infection
Aflatoxin is not a probably human carcinogen: the published evidence is sufficient.
Persistent Infection
Molecular carcinogenesis of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: one step closer to personalized medicine?
Persistent Infection
Production of extracellular virulence factors by Pseudomonas aeruginosa isolates obtained from tracheal, urinary tract, and wound infections.
Persistent Infection
Reduced Aflatoxin Exposure Presages Decline in Liver Cancer Mortality in an Endemic Region of China.
Peste-des-Petits-Ruminants
The fusion protein of peste des petits ruminants virus is a hemolysin.
Pheochromocytoma
Mitogen-activated protein kinase phosphorylation in the rostral ventrolateral medulla plays a key role in imidazoline (i1)-receptor-mediated hypotension.
Pheochromocytoma
Phosphoinositide signaling in nuclei of Friend cells: phospholipase C beta down-regulation is related to cell differentiation.
Pheochromocytoma
Pulsed electromagnetic field and relief of hypoxia-induced neuronal cell death: The signaling pathway.
Pheochromocytoma
The I1-imidazoline receptor: from binding site to therapeutic target in cardiovascular disease.
Pheochromocytoma
UTP activates phospholipase C-Ca2+ system through a receptor different from the 53-kDa ATP receptor in PC12 cells.
phospholipase c deficiency
A comparison of modified Larson and 'anatomic' posterolateral corner reconstructions in knees with combined PCL and posterolateral corner deficiency.
phospholipase c deficiency
Analysis of the phospholipase C gene of Clostridium perfringens KZ1340 isolated from Antarctic soil.
phospholipase c deficiency
Characterization of a second hamster lung fibroblast mutant with defects in phosphatidylinositol-specific phospholipase C.
phospholipase c deficiency
Control of laxity in knees with combined posterior cruciate ligament and posterolateral corner deficiency: comparison of single-bundle versus double-bundle posterior cruciate ligament reconstruction combined with modified Larson posterolateral corner reconstruction.
phospholipase c deficiency
Phosphatidylcholine and 4-methylumbelliferyl phosphorylcholine hydrolysis by purified placental sphingomyelinase.
phospholipase c deficiency
Phospholipase C beta 1 deficiency is associated with early-onset epileptic encephalopathy.
phospholipase c deficiency
Phospholipase C?1 represses colorectal cancer growth by inhibiting the Wnt/?-catenin signaling axis.
phospholipase c deficiency
Suppression of phospholipase C beta, gamma, and delta families alters cell growth and phosphatidylinositol 4,5-bisphosphate levels.
phospholipase c deficiency
The role of PCL reconstruction in knees with combined PCL and posterolateral corner deficiency.
Photosensitivity Disorders
Virulence of Pseudomonas aeruginosa cells surviving photodynamic treatment with toluidine blue.
Pinealoma
Pharmacological characterization of adenosine receptors in PGT-beta mouse pineal gland tumour cells.
Pinealoma
Selective inhibition of beta(2)-adrenergic receptor-mediated cAMP generation by activation of the P2Y(2) receptor in mouse pineal gland tumor cells.
Pinealoma
Two distinct P2 purinergic receptors, P2Y and P2U, are coupled to phospholipase C in mouse pineal gland tumor cells.
Pituitary Neoplasms
'Cross-talk' between phospholipase C and adenylyl cyclase involves regulation of G-protein levels in GH3 rat pituitary cells.
Pituitary Neoplasms
Bombesin stimulates prolactin secretion from cultured rat pituitary tumour cells (GH4C1) via activation of phospholipase C.
Pituitary Neoplasms
The thyroliberin receptor interacts directly with a stimulatory guanine-nucleotide-binding protein in the activation of adenylyl cyclase in GH3 rat pituitary tumour cells. Evidence obtained by the use of antisense RNA inhibition and immunoblocking of the stimulatory guanine-nucleotide-binding protein.
Pleural Effusion
Pleural lavage cytology before and after lung resection in non-small cell lung cancer patients.
Pleural Effusion
Prognostic significance and possibility in guiding adjuvant therapy of the pleural lavage cytology in patients with non-small cell lung cancer.
Pleural Effusion
Pulmonary lymphangitic carcinomatosis in liver carcinoma: a rare case report and literature review.
Pleural Effusion
Recurrence patterns in patients with early stage non-small cell lung cancers undergoing positive pleural lavage cytology.
Pleural Effusion, Malignant
Clinical relevance of intraoperative pleural lavage cytology in non-small cell lung cancer.
Pleural Effusion, Malignant
The value of pleural lavage cytology examined during surgery for primary lung cancer.
Pleurisy
Pleural lavage cytology immediately after thoracotomy and before closure of the thoracic cavity for lung cancer without pleural effusion and dissemination: clinicopathologic and prognostic analysis.
Pleurisy
Prognostic value of intraoperative pleural lavage cytology for lung cancer without carcinomatous pleuritis: importance in patients with early stage disease during long-term follow-up.
Pleuropneumonia
Characterization of a non-hemolytic mutant of Actinobacillus pleuropneumoniae serotype 5: role of the 110 kilodalton hemolysin in virulence and immunoprotection.
Pleuropneumonia
Pathogenicity of Haemophilus pleuropneumoniae for laboratory animals and possible role of its hemolysin for production of pleuropneumonia.
Pleuropneumonia
Protective efficacy of an affinity-purified hemolysin vaccine against experimental swine pleuropneumonia.
Pleuropneumonia
Protective efficacy of conjugate vaccines against experimental challenge with porcine Actinobacillus pleuropneumoniae.
Pneumococcal Infections
Evaluation of the role of the pneumococcal Forssman antigen (F-polysaccharide) in the cross-serotype protection induced by pneumococcal subcellular preparations.
Pneumonia
Alveolar epithelial injury and pleural empyema in acute P. aeruginosa pneumonia in anesthetized rabbits.
Pneumonia
Differential gene expression in Streptococcus pneumoniae in response to various iron sources.
Pneumonia
Direct pulmonary delivery of solubilized curcumin reduces severity of lethal pneumonia.
Pneumonia
E. coli virulence factor hemolysin induces neutrophil apoptosis and necrosis/lysis in vitro and necrosis/lysis and lung injury in a rat pneumonia model.
Pneumonia
Enzyme-linked immunosorbent assay for detection of antibodies to Pseudomonas aeruginosa exoproteins.
Pneumonia
Low dose inflammatory potential of silica particles in human-derived THP-1 macrophage cell culture studies - Mechanism and effects of particle size and iron.
Pneumonia
Lung vascular injury after administration of viable hemolysin-forming Escherichia coli in isolated rabbit lungs.
Pneumonia
Phenotypic comparison of Pseudomonas aeruginosa strains isolated from a variety of clinical sites.
Pneumonia
Phosphonate coating of SiO2 nanoparticles abrogates inflammatory effects and local changes of the lipid composition in the rat lung: a complementary bioimaging study.
Pneumonia
Pulmonary inflammation induced by Pseudomonas aeruginosa lipopolysaccharide, phospholipase C, and exotoxin A: role of interferon regulatory factor 1.
Pneumonia
Relatedness of Streptococcus suis isolates of various serotypes and clinical backgrounds as evaluated by macrorestriction analysis and expression of potential virulence traits.
Pneumonia
Surfactant dysfunction and lung injury due to the E. coli virulence factor hemolysin in a rat pneumonia model.
Pneumonia
The hemolytic and cytolytic activity of group B streptococcal hemolysin and its possible role in early onset group B streptococcal disease.
Pneumonia
[Case of pneumonia with hemolysin and high titer of cold agglutinin reactive in 2 phases to chicken erythrocytes]
Pneumonia
[Studies on staphylococcal infection. I. Anti-alpha hemolysin titer in the sera of rabbits with experimentally induced staphylococcal pneumonia]
Pneumonia, Bacterial
Discontinuing cotrimoxazole preventive therapy in HIV-infected adults who are stable on antiretroviral treatment in Uganda (COSTOP): A randomised placebo controlled trial.
Pneumonia, Mycoplasma
Mycoplasma pneumoniae infection complicated by paroxysmal cold hemoglobinuria with anti-P specificity of biphasic hemolysin.
Pneumonia, Pneumococcal
Diagnosis of pneumococcal pneumonia by enzyme-linked immunosorbent assay of antibodies to pneumococcal hemolysin (pneumolysin).
Pneumonia, Staphylococcal
[Studies on staphylococcal infection. I. Anti-alpha hemolysin titer in the sera of rabbits with experimentally induced staphylococcal pneumonia]
Polycystic Kidney Diseases
Overexpression of kidney phosphatidylinositol 4-kinasebeta and phospholipase C(gamma1) proteins in two rodent models of polycystic kidney disease.
Porcine Reproductive and Respiratory Syndrome
Autophagy and innate immunity: Insights from invertebrate model organisms.
Porcine Reproductive and Respiratory Syndrome
Phospholipase C signaling is involved in porcine reproductive and respiratory syndrome virus infection in cell cultures.
Porphyria, Acute Intermittent
Erythrocyte porphobilinogen deaminase activity and primary liver cancer.
Poxviridae Infections
Inhibition of agonist-induced activation of phospholipase C following poxvirus infection.
Pre-Eclampsia
Markers for endothelial injury, clotting and platelet activation in preeclampsia.
Premature Birth
Cervicovaginal microflora and pregnancy outcome: results of a double-blind, placebo-controlled trial of erythromycin treatment.
Premature Birth
Phospholipase C activity in microorganisms associated with reproductive tract infection.
Primary Immunodeficiency Diseases
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
Prostatic Neoplasms
Calcium store contents control the expression of TRPC1, TRPC3 and TRPV6 proteins in LNCaP prostate cancer cell line.
Prostatic Neoplasms
Effect of m-3M3FBS on Ca2+ movement in PC3 human prostate cancer cells.
Prostatic Neoplasms
Endogenous TRPV1 stimulation leads to the activation of the inositol phospholipid pathway necessary for sustained Ca(2+) oscillations.
Prostatic Neoplasms
Measurements of cancer extent in a conservatively treated prostate cancer biopsy cohort.
Prostatic Neoplasms
Melatonin impedes prostate cancer metastasis by suppressing MMP-13 expression.
Prostatic Neoplasms
Phospholipase C (PLC)? Promotes Androgen Receptor Antagonist Resistance via the Bone Morphogenetic Protein (BMP)-6/SMAD Axis in a Castration-Resistant Prostate Cancer Cell Line.
Prostatitis
Biofilm formation in uropathogenic Escherichia coli strains: relationship with prostatitis, urovirulence factors and antimicrobial resistance.
Prostatitis
Differences in virulence factors among clinical isolates of Escherichia coli causing cystitis and pyelonephritis in women and prostatitis in men.
Protein-Energy Malnutrition
[Antioxidant and/or free radical scavenger vitamins in tropical medicine]
Proteinuria
Effect of Thiazolidinedione Treatment on Proteinuria and Renal Hemodynamic in Type 2 Diabetic Patients with Overt Nephropathy.
Pseudomonas Infections
Enzyme-linked immunosorbent assay for detection of antibodies to Pseudomonas aeruginosa exoproteins.
Pseudomonas Infections
Hemolytic Phospholipase C Inhibition Protects Lung Function during Pseudomonas aeruginosa Infection.
Pseudomonas Infections
Virulence factors are released from Pseudomonas aeruginosa in association with membrane vesicles during normal growth and exposure to gentamicin: a novel mechanism of enzyme secretion.
Pseudomonas Infections
[Serodiagnosis of Pseudomonas aeruginosa infections in mucoviscidosis: comparative study of Western blotting, ELISA exotoxin A and ELISA phospholipase C]
Psoriasis
Glycosylphosphatidylinositol (GPI)-anchored membrane proteins are constitutively down-regulated in psoriatic skin.
Psoriasis
Lipocortin I (annexin I) is preferentially localized on the plasma membrane in keratinocytes of psoriatic lesional epidermis as shown by immunofluorescence microscopy.
Psoriasis
Pityriasis lichenoides chronica presenting with bilateral palmoplantar involvement.
Psychomotor Agitation
Pathological laughter as prodromal manifestation of transient ischemic attacks--case report and brief review.
Pulmonary Disease, Chronic Obstructive
A Genome-Wide Linkage Study for Chronic Obstructive Pulmonary Disease in a Dutch Genetic Isolate Identifies Novel Rare Candidate Variants.
Pulmonary Disease, Chronic Obstructive
Acute Tetrahydrobiopterin Improves Endothelial Function in Patients With COPD.
Pulmonary Disease, Chronic Obstructive
Eosinophilic inflammation in COPD: from an inflammatory marker to a treatable trait.
Pulmonary Disease, Chronic Obstructive
Extent and cost of inappropriate use of tumour markers in patients with pulmonary disease: a multicentre retrospective study in Shanghai, China.
Pulmonary Disease, Chronic Obstructive
Molecular mechanisms of beta2-adrenergic receptor function and regulation.
Pulmonary Edema
Release of von Willebrand factor antigen (vWF:Ag) and eicosanoids during acute injury to the isolated rat lung.
Pulmonary Edema
Thromboxane-mediated hypertension and vascular leakage evoked by low doses of Escherichia coli hemolysin in rabbit lungs.
Pulmonary Embolism
Preoperative platelet count and postoperative blood loss in patients undergoing hip surgery: an inverse correlation.
Pyelonephritis
?-Hemolysin of uropathogenic E. coli regulates NLRP3 inflammasome activation and mitochondrial dysfunction in THP-1 macrophages.
Pyelonephritis
Alpha-hemolysin contributes to the pathogenicity of piliated digalactoside-binding Escherichia coli in the kidney: efficacy of an alpha-hemolysin vaccine in preventing renal injury in the BALB/c mouse model of pyelonephritis.
Pyelonephritis
Binding to and killing of human renal epithelial cells by hemolytic P-fimbriated E. coli.
Pyelonephritis
Carbon monoxide prevents apoptosis induced by uropathogenic Escherichia coli toxins.
Pyelonephritis
Community-acquired pyelonephritis in adults: characteristics of E. coli isolates in bacteremic and non-bacteremic patients.
Pyelonephritis
Construction of a flagellum-negative mutant of Proteus mirabilis: effect on internalization by human renal epithelial cells and virulence in a mouse model of ascending urinary tract infection.
Pyelonephritis
Cytolethality of hemolytic Escherichia coli to primary human renal proximal tubular cell cultures obtained from different donors.
Pyelonephritis
Cytotoxicity of hemolytic, cytotoxic necrotizing factor 1-positive and -negative Escherichia coli to human T24 bladder cells.
Pyelonephritis
Differences in virulence factors among clinical isolates of Escherichia coli causing cystitis and pyelonephritis in women and prostatitis in men.
Pyelonephritis
Distribution of uropathogenic virulence genes in Escherichia coli isolated from patients with urinary tract infection.
Pyelonephritis
Distribution of virulence factors in Escherichia coli isolated from urine of cystitis patients.
Pyelonephritis
Expression and detection of pap-, sfa-, and afa-encoded fimbrial adhesin systems among uropathogenic Escherichia coli.
Pyelonephritis
Gal-Gal binding and hemolysin phenotypes and genotypes associated with uropathogenic Escherichia coli.
Pyelonephritis
Gestational pyelonephritis--associated Escherichia coli isolates represent a nonrandom, closely related population.
Pyelonephritis
Hemagglutination of human type O erythrocytes, hemolysin production, and serogrouping of Escherichia coli isolates from patients with acute pyelonephritis, cystitis, and asymptomatic bacteriuria.
Pyelonephritis
Hemagglutinin, urease, and hemolysin production by Proteus mirabilis from clinical sources.
Pyelonephritis
In vivo function of hemolysin in the nephropathogenicity of Escherichia coli.
Pyelonephritis
Interleukin-6 and interleukin-8 in serum and urine in patients with acute pyelonephritis in relation to bacterial-virulence-associated traits and renal function.
Pyelonephritis
Invasive Escherichia coli infections in children: bacterial characteristics in different age groups and clinical entities.
Pyelonephritis
Prevalence of urovirulence genes cnf, hlyD, sfa/foc, and papGIII in fecal Escherichia coli from healthy dogs and their owners.
Pyelonephritis
Prevalence of virulence genes in Escherichia coli strains isolated from Romanian adult urinary tract infection cases.
Pyelonephritis
Properties of Escherichia coli isolates from urinary tract infections in boys.
Pyelonephritis
Serological response to the P fimbriae of uropathogenic Escherichia coli in pyelonephritis.
Pyelonephritis
The prevalence of virulence genes of E. coli strains isolated from children with urinary tract infection.
Pyelonephritis
Virulence characteristics of Escherichia coli in relation to host response in men with symptomatic urinary tract infection.
Pyelonephritis
Virulence factors of Escherichia coli in urinary isolates from pregnant women.
Pyelonephritis
Virulence of Escherichia coli strains in relation to their hemolysin formation, mannose-resistant hemagglutination, hydroxamate production, K 1-antigen and the plasmid profile in patients with chronic pyelonephritis.
Pyelonephritis
Virulence properties of Escherichia coli strains in patients with chronic pyelonephritis.
Pyelonephritis
Virulence-associated traits in Escherichia coli causing first and recurrent episodes of urinary tract infection in children with or without vesicoureteral reflux.
Pyelonephritis
[Acute pyelonephritis: bacteriological data and general course of germ resistance]
Pyoderma
Case Report: A Rare Case of Autoinflammatory Phospholipase C?2 (PLC?2)-Associated Antibody Deficiency and Immune Dysregulation Complicated With Gangrenous Pyoderma and Literature Review.
Rabies
Interscience conference on antimicrobial agents and chemotherapy - 50th annual meeting - research on promising new agents: part 1.
Renal Insufficiency
Surgically induced uremia in rats. II: Osseous PTH-susceptible signaling systems as predictors of bone resorption.
Renal Insufficiency
The effect of propionyl L-carnitine on skeletal muscle metabolism in renal failure.
Renal Insufficiency, Chronic
Propionyl-L-carnitine therapy: effects on endothelin-1 and homocysteine levels in patients with peripheral arterial disease and end-stage renal disease.
Reperfusion Injury
Differential effects of phospholipase inhibitors on free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury.
Reproductive Tract Infections
Phospholipase C activity in microorganisms associated with reproductive tract infection.
Respiratory Hypersensitivity
A Genome-Wide Linkage Study for Chronic Obstructive Pulmonary Disease in a Dutch Genetic Isolate Identifies Novel Rare Candidate Variants.
Respiratory Insufficiency
A Rare Case of Progressive Dyspnea and Bilateral Lung Infiltration in a Young Male.
Respiratory Insufficiency
Lung vascular injury after administration of viable hemolysin-forming Escherichia coli in isolated rabbit lungs.
Respiratory Insufficiency
Thromboxane-mediated hypertension and vascular leakage evoked by low doses of Escherichia coli hemolysin in rabbit lungs.
Respiratory Tract Infections
Pseudomonas aeruginosa: biology, mechanisms of virulence, epidemiology.
Retinal Degeneration
Accumulation of calcium in degenerating photoreceptors of several Drosophila mutants.
Retinal Degeneration
Ceramidase expression facilitates membrane turnover and endocytosis of rhodopsin in photoreceptors.
Retinal Degeneration
Functional INAD complexes are required to mediate degeneration in photoreceptors of the Drosophila rdgA mutant.
Retinal Degeneration
Loss of the phospholipase C gene product induces massive endocytosis of rhodopsin and arrestin in Drosophila photoreceptors.
Retinal Degeneration
Modulating sphingolipid biosynthetic pathway rescues photoreceptor degeneration.
Retinal Degeneration
Regulation of PLC-mediated signalling in vivo by CDP-diacylglycerol synthase.
Retinal Degeneration
The rat phospholipase C beta 4 gene is expressed at high abundance in cerebellar Purkinje cells.
Retinal Degeneration
TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease.
Retinal Detachment
Central posterior lens capsule used instead of inverted ILM flap: a clinic-pathological case report.
Rhinitis, Allergic
[The promoting research of phospholipase C epsilon-1 on nasal Th2 cell polarization].
ring-type e3 ubiquitin transferase deficiency
Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling.
Rosacea
Long-term efficacy and safety of topical PRK 124 (0.125%) lotion (Pyratine-XR) in the treatment of mild-to-moderate rosacea.
Rubella
Improved rubella hemagglutination inhibtion test: inactivation of non-immunoglobulin hemagglutination inhibitors by phospholipase C.
Rubella
Viral antibody titers. Comparison in patients with multiple sclerosis and rheumatoid arthritis.
Sarcoidosis
Peripheral blood gene expression as a novel genomic biomarker in complicated sarcoidosis.
Sarcoma
PLCG2 as a potential indicator of tumor microenvironment remodeling in soft tissue sarcoma.
Sarcoma
Sinomenine potentiates P815 cell degranulation via upregulation of Ca2+ mobilization through the Lyn/PLC?/IP3R pathway.
Sarcoma 180
Combination chemotherapy with Clostridium perfringens phospholipase C and cytosine antimetabolites: complementary inhibition directed at membrane lipids.
Sarcoma 180
[Studies on the antitumor effect of Clerodendrum bungei Steud or C. foetidum Bge.]
Sarcoma, Yoshida
Phospholipase C activity of cobra venom and lysis of Yoshida sarcoma cells.
Scleromyxedema
Breast cancer cutaneous metastases mimicking Papilloma Cutis Lymphostatica. Biopsy to avoid pitfalls.
Seizures
Altered PLC?-1 expression in the gerbil hippocampal complex following spontaneous seizure.
Seizures
Cerebral phosphoinositide, triacylglycerol and energy metabolism during sustained seizures induced by bicuculline.
Seizures
Deletion of phospholipase C beta4 in thalamocortical relay nucleus leads to absence seizures.
Seizures
Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling.
Seizures
Ethological resolution of behavioral topography and D2-like vs. D1-like agonist responses in congenic D4 dopamine receptor "knockouts": identification of D4:D1-like interactions.
Seizures
Neurotoxicity of a novel local anesthetic agent, ropivacaine: the possible roles of bursts of potential and cytoplasmic second messenger.
Seizures
The Neuroprotective Effects of Histamine H3 Receptor Antagonist E177 on Pilocarpine-Induced Status Epilepticus in Rats.
Seizures
Topiramate in medically intractable partial epilepsies: double-blind placebo-controlled randomized parallel group trial. Korean Topiramate Study Group.
Sepsis
Aloe-Emodin-Mediated Photodynamic Therapy Attenuates Sepsis-Associated Toxins in Selected Gram-Positive Bacteria In Vitro.
Sepsis
Alpha-hemolysin contributes to the pathogenicity of piliated digalactoside-binding Escherichia coli in the kidney: efficacy of an alpha-hemolysin vaccine in preventing renal injury in the BALB/c mouse model of pyelonephritis.
Sepsis
Antibody response to alpha- and betahemolysin from Staphylococcus aureus in patients with staphylococcal infections and in normals.
Sepsis
Biochemical and biological properties of Staphylococcus aureus septicemia strains in relation to clinical characteristics.
Sepsis
Case report. Clostridium perfringens septicemia with detection of phospholipase C activity in the serum.
Sepsis
Complex Multilevel Control of Hemolysin Production by Uropathogenic Escherichia coli.
Sepsis
E. coli hemolysin-induced lipid mediator metabolism in alveolar macrophages: impact of eicosapentaenoic acid.
Sepsis
Escherichia vulneris: an unusual cause of complicated diarrhoea and sepsis in an infant. A case report and review of literature.
Sepsis
Genome Sequence of Elizabethkingia meningoseptica EM1, Isolated from a Patient with a Bloodstream Infection.
Sepsis
Glycan specificity of the Vibrio vulnificus hemolysin lectin outlines evolutionary history of membrane targeting by a toxin family.
Sepsis
Heterogeneity of hemolysin expression during neonatal Streptococcus agalactiae sepsis.
Sepsis
Impact of arachidonic versus eicosapentaenoic acid on exotonin-induced lung vascular leakage: relation to 4-series versus 5-series leukotriene generation.
Sepsis
Inflammatory lipid mediator generation elicited by viable hemolysin-forming Escherichia coli in lung vasculature.
Sepsis
Leukotriene-mediated coronary vasoconstriction and loss of myocardial contractility evoked by low doses of Escherichia coli hemolysin in perfused rat hearts.
Sepsis
Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis.
Sepsis
Lung vascular injury after administration of viable hemolysin-forming Escherichia coli in isolated rabbit lungs.
Sepsis
Modulation of mouse endotoxin shock by inhibition of phosphatidylcholine-specific phospholipase C.
Sepsis
Pathogenicity of an enterotoxigenic Escherichia coli hemolysin (hlyA) mutant in gnotobiotic piglets.
Sepsis
Phospholipase C Activator m-3M3FBS Protects against Morbidity and Mortality Associated with Sepsis.
Sepsis
Porcine hepatic response to sepsis and its amplification by an adrenergic receptor alpha1 agonist and a beta2 antagonist.
Sepsis
Relatedness of Streptococcus suis isolates of various serotypes and clinical backgrounds as evaluated by macrorestriction analysis and expression of potential virulence traits.
Sepsis
Sensitively and quickly detecting Vibrio vulnificus by real time recombinase polymerase amplification targeted to vvhA gene.
Sepsis
The Extracellular Domain of the ?2 Integrin ? Subunit (CD18) Is Sufficient for Escherichia coli Hemolysin and Aggregatibacter actinomycetemcomitans Leukotoxin Cytotoxic Activity.
Sepsis
Thromboxane-mediated hypertension and vascular leakage evoked by low doses of Escherichia coli hemolysin in rabbit lungs.
Sepsis
[In vitro virulence of wound infecting staphylococcal isolates from severely burned patients]
Serratia Infections
Role of cell-bound hemolysin as a pathogenicity factor for Serratia infections.
Severe Acute Respiratory Syndrome
Host factor prioritization for pan-viral genetic perturbation screens using random intercept models and network propagation.
Severe Dengue
Joint ancestry and association test indicate two distinct pathogenic pathways involved in classical dengue fever and dengue shock syndrome.
Shock, Septic
Antibiotic susceptibility of human-associated Staphylococcus aureus and its relation to agr typing, virulence genes, and biofilm formation.
Shock, Septic
Biochemical and biological properties of Staphylococcus aureus septicemia strains in relation to clinical characteristics.
Shock, Septic
Characterization of oxacillin-susceptible mecA-positive Staphylococcus aureus: a new type of MRSA.
Shock, Septic
CtaA of Staphylococcus aureus is required for starvation survival, recovery, and cytochrome biosynthesis.
Shock, Septic
Eugenol reduces the expression of virulence-related exoproteins in Staphylococcus aureus.
Shock, Septic
IBT-V02: A Multicomponent Toxoid Vaccine Protects Against Primary and Secondary Skin Infections Caused by Staphylococcus aureus.
Shock, Septic
Iclaprim: a differentiated option for the treatment of skin and skin structure infections.
Shock, Septic
Intravitreal human immune globulin in a rabbit model of Staphylococcus aureus toxin-mediated endophthalmitis: a potential adjunct in the treatment of endophthalmitis.
Shock, Septic
Leukotriene-mediated coronary vasoconstriction and loss of myocardial contractility evoked by low doses of Escherichia coli hemolysin in perfused rat hearts.
Shock, Septic
Modulation of cyclooxygenase-2 expression by phosphatidylcholine specific phospholipase C and D in macrophages stimulated with lipopolysaccharide.
Shock, Septic
Modulation of mouse endotoxin shock by inhibition of phosphatidylcholine-specific phospholipase C.
Shock, Septic
Molecular characterization and antibiotic resistance of Staphylococcus spp. isolated from cheese processing plants.
Shock, Septic
Molecular characterization of methicillin-resistant Staphylococcus aureus isolates from rural community settings in Trinidad and Tobago.
Shock, Septic
Neutralization of staphylococcal exotoxins in vitro by human-origin intravenous immunoglobulin.
Shock, Septic
Phospholipase C Activator m-3M3FBS Protects against Morbidity and Mortality Associated with Sepsis.
Shock, Septic
Staphylococcus aureus nasal carriage in hemodialysis centers of Fez, Morocco.
Shock, Septic
The role of virulence factors in the outcome of staphylococcal peritonitis in CAPD patients.
Skin Diseases
Atypical manifestations of pityriasis lichenoides chronica: development into paraneoplasia and non-Hodgkin lymphomas of the skin.
Skin Diseases
Breast cancer cutaneous metastases mimicking Papilloma Cutis Lymphostatica. Biopsy to avoid pitfalls.
Skin Diseases
Genomic analysis of variability in Delta-toxin levels between Staphylococcus aureus strains.
Skin Diseases
Lipocortin I (annexin I) is preferentially localized on the plasma membrane in keratinocytes of psoriatic lesional epidermis as shown by immunofluorescence microscopy.
Skin Neoplasms
Predictors of skin self-examination in subjects attending a pigmented lesion clinic in Italy.
Sleep Initiation and Maintenance Disorders
Almorexant, a dual orexin receptor antagonist for the treatment of insomnia.
Sleep Initiation and Maintenance Disorders
Casopitant, a neurokinin-1 receptor antagonist with anti-emetic and anti-nausea activities.
Small Cell Lung Carcinoma
Effect of guanine and adenine nucleotides on bombesin-stimulated phospholipase C activity in membranes from Swiss 3T3 and small cell lung carcinoma cells.
Small Cell Lung Carcinoma
FGFR1 is critical for Rbl2 loss-driven tumor development and requires PLCG1 activation for continued growth of small cell lung cancer.
Small Cell Lung Carcinoma
Identification of a novel phospholipase C family gene at chromosome 2q33 that is homozygously deleted in human small cell lung carcinoma.
Soft Tissue Infections
Protective efficacy of a novel alpha hemolysin subunit vaccine (AT62) against Staphylococcus aureus skin and soft tissue infections.
Soft Tissue Infections
Role of Antibodies in Protection Elicited by Active Vaccination with Genetically Inactivated Alpha Hemolysin in a Mouse Model of Staphyloccocus aureus Skin and Soft Tissue Infections.
Soft Tissue Infections
The Impact of the Staphylococcus aureus Virulome on Infection in a Developing Country: A Cohort Study.
Spasm
Diltiazem Inhibits Coronary Spasm via Inhibition of Cav1.2Phosphorylation and Protein Kinase C Activation in a Mouse Model of Coronary Spastic Angina.
Spasm
Endocannabinoid system modulator use in everyday clinical practice in the UK and Spain.
Spasm
Enhanced phospholipase C activity in the cultured skin fibroblast obtained from patients with coronary spastic angina: possible role for enhanced vasoconstrictor response.
Spasm
Enhanced transient receptor potential channel-mediated Ca(2+) influx in the cells with phospholipase C-?1 overexpression: its possible role in coronary artery spasm.
sphingomyelin phosphodiesterase deficiency
Deficiency of phospholipase C acting on phosphatidylglycerol in Niemann-Pick disease.
sphingomyelin phosphodiesterase deficiency
Isolation of Alpha-Toxin-Deficient Clostridium perfringens Type F from Sewage Influents and Effluents.
Squamous Cell Carcinoma of Head and Neck
Combined inhibition of PLC{gamma}-1 and c-Src abrogates epidermal growth factor receptor-mediated head and neck squamous cell carcinoma invasion.
Squamous Cell Carcinoma of Head and Neck
Epidermal growth factor receptor-stimulated activation of phospholipase Cgamma-1 promotes invasion of head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells.
Squamous Cell Carcinoma of Head and Neck
Hyaluronan-CD44 promotes phospholipase C-mediated Ca2+ signaling and cisplatin resistance in head and neck cancer.
Squamous Cell Carcinoma of Head and Neck
Phospholipase C gamma 1 is a potential prognostic biomarker for patients with locally advanced and resectable oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Pulmonary lymphangitic carcinomatosis from an oropharyngeal squamous cell carcinoma: a case report.
Squamous Cell Carcinoma of Head and Neck
Pulmonary lymphangitic carcinomatosis from head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
The influence of hyaluronan-CD44 interaction on topoisomerase II activity and etoposide cytotoxicity in head and neck cancer.
Staphylococcal Infections
Studies on the pathogenesis of staphylococcal infection. V. Purification and characterization of staphylococcal alpha hemolysin.
Staphylococcal Infections
Studies on the pathogenesis of staphylococcal infection. VI. Mechanism of immunity conferred by anti-alpha hemolysin.
Staphylococcal Infections
STUDIES ON THE PATHOGENESIS OF STAPHYLOCOCCAL INFECTION. VII. CHARACTERIZATION OF THE DERMAL REACTION TO PURIFIED ALPHA HEMOLYSIN IN NORMAL AND IMMUNE ANIMALS.
Staphylococcal Infections
STUDIES ON THE PATHOGENESIS OF STAPHYLOCOCCAL INFECTION. VIII. THE HUMAN CUTANEOUS REACTION TO INJECTION OF ALPHA HEMOLYSIN.
Staphylococcal Infections
[Studies on staphylococcal infection. I. Anti-alpha hemolysin titer in the sera of rabbits with experimentally induced staphylococcal pneumonia]
Staphylococcal Infections
[Studies on staphylococcal infection. II. Anti-alpha hemolysin titer in the sera of human subjects with staphylococcal disease and normal human subjects]
Staphylococcal Infections
[Value of anti hemolysin and anti-gammahemolysin assays for the diagnosis of staphylococcal infections, particularly of osteoarthritis (author's transl)]
Staphylococcal Skin Infections
[Staphylococcal hemolysins and autovaccine applications in staphylococcal infections]
Starvation
A novel phosphatidylcholine-hydrolyzing phospholipase C induced by phosphate starvation in Arabidopsis.
Starvation
Cloning of two distinct hemolysin genes from Porphyromonas (Bacteroides) gingivalis in Escherichia coli.
Starvation
Hemolytic activity in the periodontopathogen Porphyromonas gingivalis: kinetics of enzyme release and localization.
Starvation
Osmoprotectant-dependent expression of plcH, encoding the hemolytic phospholipase C, is subject to novel catabolite repression control in Pseudomonas aeruginosa PAO1.
Starvation
Phospholipase C in Dictyostelium discoideum. Cyclic AMP surface receptor and G-protein-regulated activity in vitro.
Starvation
The dynamics of carbon stored in xylem sapwood to drought-induced hydraulic stress in mature trees.
Status Epilepticus
Reduced expression of Phospholipase C beta in hippocampal interneuron during pilocarpine induced status epilepticus in mice.
Stillbirth
Reproductive factors, menopausal hormone therapies and primary liver cancer risk: a systematic review and dose-response meta-analysis of observational studies.
Stomach Neoplasms
A Rare Case of Pulmonary Lymphangitic Carcinomatosis in a Young Adult with Carcinoma Stomach.
Stomach Neoplasms
Changes in serum levels of Forssman-like antibody in patients with gastric cancer.
Stomach Neoplasms
Clinical significance of telomerase activity in peritoneal lavage fluid from patients with gastric cancer and its relationship with cellular proliferation.
Stomach Neoplasms
Efficacy of S-1 for gastric cancer patients with positive peritoneal lavage cytology.
Stomach Neoplasms
Molecular characterization and significance for prognosis of free gastric cancer cells in the peritoneal cavity.
Stomach Neoplasms
Peritoneal lavage cytology and carcinoembryonic antigen determination in predicting peritoneal metastasis and prognosis of gastric cancer.
Stomach Neoplasms
Peritoneal wash cytology in gastric carcinoma. Prognostic significance and therapeutic consequences.
Stomach Neoplasms
Phospholipase C delta 1 is a novel 3p22.3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric cancer.
Stomach Neoplasms
PSCA and MUC1 gene polymorphisms are linked with gastric cancer and pre-malignant gastric conditions.
Stomach Neoplasms
Pulmonary lymphangitis carcinomatosis: systematic review and meta-analysis of case reports, 1970-2018.
Stomach Neoplasms
The role of tissue thromboplastin in the development of DIC accompanying neoplastic diseases.
Stomach Neoplasms
When is curative gastrectomy justified for gastric cancer with positive peritoneal lavage cytology but negative macroscopic peritoneal implant?
Stomach Neoplasms
[Expression of phospholipase C epsilon-1 in gastric cancer and its association with prognosis].
Streptococcal Infections
[Properties of a hemolysin produced by group C streptococci isolated from hemolytic streptococcal infection in formosan squirrels]
Stroke
Antidepressant treatment of pathologic laughing or crying in elderly stroke patients.
Stroke
Coordinated increase of reliable cortical and striatal ensemble activations during recovery after stroke.
Stroke
Du rire aux larmes: pathological laughing and crying in patients with traumatic brain injury and treatment with lamotrigine.
Stroke
Hemodynamic and metabolic activities of propionyl-L-carnitine in rats with pressure-overload cardiac hypertrophy.
Stroke
Thalamic Nuclei and Thalamocortical Pathways After Left Hemispheric Stroke and Their Association with Picture Naming.
Stupor
Effects of breathing-gas pressure on pulmonary function and work capacity during immersion.
Subarachnoid Hemorrhage
Analysis of phospholipase C gene in patients with subarachnoid hemorrhage due to ruptured intracranial saccular aneurysm.
Subarachnoid Hemorrhage
Development of a liquid chromatography-mass spectrometry based enzyme activity assay for phosphatidylcholine-specific phospholipase C.
Subarachnoid Hemorrhage
Phospholipase C activity in cerebrospinal fluid following subarachnoid hemorrhage related to brain damage.
Supranuclear Palsy, Progressive
Association of ABI3 and PLCG2 missense variants with disease risk and neuropathology in Lewy body disease and progressive supranuclear palsy.
Synostosis
Linear craniectomy for early posterior decompression in craniosynostoses: technique and results.
Tachycardia
Effects of phospholipase C, a tissue thromboplastin inhibitor, on pulmonary microembolism after missile injury of the limb.
Tachycardia
Vibrio vulnificus hemolysin dilates rat thoracic aorta by activating guanylate cyclase.
Tachycardia, Sinus
Adenosine-5'-triphosphate-induced sinus tachycardia mediated by prostaglandin synthesis via phospholipase C in the rabbit heart.
Teratocarcinoma
Differentiation of F9 teratocarcinoma stem cells to primitive endoderm is regulated by the Gialpha2/Gsalpha axis via phospholipase C and not adenylylcyclase.
Teratocarcinoma
Morphogen-induced decline in Gialpha2 triggers F9 teratocarcinoma stem cell progression via phospholipase C and mitogen-activated protein kinase.
Thromboangiitis Obliterans
Phosphatidylcholine-specific phospholipase C activity and level increase evidently in thromboangitis obliterans.
Thrombocytopenia
Thrombocytopenia after implantation of the Perceval S aortic bioprosthesis.
Thrombocytopenia
[A case of paroxysmal cold hemoglobinuria with thrombocytopenia (Evans' syndrome), and without anti-P specificity of biphasic hemolysin]
Thrombosis
Elevation of endothelial microparticles, platelets, and leukocyte activation in patients with venous thromboembolism.
Thrombosis
Pharmacological Blockade of Glycoprotein VI Promotes Thrombus Disaggregation in the Absence of Thrombin.
Thymoma
Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo.
Thyroid Neoplasms
Absence of activating mutations of the genes encoding the alpha-subunits of G11 and Gq in thyroid neoplasia.
Thyroid Neoplasms
An InDel in Phospholipase-C-B-1 Is Linked with Euthyroid Multinodular Goiter.
Thyroid Neoplasms
Phospholipase C Delta 3 inhibits apoptosis and promotes proliferation, migration, and invasion of thyroid cancer cells via Hippo pathway.
Thyroid Neoplasms
Pulmonary lymphangitic carcinomatosis (PLC): spectrum of FDG-PET findings.
Thyroid Neoplasms
Suppression of thyrotropin receptor-G protein-phospholipase C coupling by activation of protein kinase C in thyroid carcinoma cells.
Thyroid Neoplasms
Thyroid-stimulating hormone activates phospholipase C in normal and neoplastic thyroid tissue.
Toxemia
Dissecting the contributions of Clostridium perfringens type C toxins to lethality in the mouse intravenous injection model.
Toxoplasmosis
Toxoplasma gondii: role of the phosphatidylcholine-specific phospholipase C during cell invasion and intracellular development.
Transfusion Reaction
Complement activating ABO anti-A IgM/IgG act synergistically to cause erythrophagocytosis: implications among minor ABO incompatible transfusions.
Transfusion Reaction
Observations on the mechanism of hemolytic transfusion reactions occurring without demonstrable hemolysin.
Trauma, Nervous System
Promoting nerve regeneration in a neurotmesis rat model using poly(DL-lactide-?-caprolactone) membranes and mesenchymal stem cells from the Wharton's jelly: in vitro and in vivo analysis.
Triple Negative Breast Neoplasms
Development, synthesis and biological investigation of a novel class of potent PC-PLC inhibitors.
Triple Negative Breast Neoplasms
Nonprotecting Group Synthesis of a Phospholipase C Activatable Probe with an Azo-Free Quencher.
Tuberculosis
A species-specific nucleotide sequence of Mycobacterium tuberculosis encodes a protein that exhibits hemolytic activity when expressed in Escherichia coli.
Tuberculosis
Activation of human neutrophils by Mycobacterium tuberculosis H37Ra involves phospholipase C gamma 2, Shc adapter protein, and p38 mitogen-activated protein kinase.
Tuberculosis
Analysis of genetic polymorphisms affecting the four phospholipase C (plc) genes in Mycobacterium tuberculosis complex clinical isolates.
Tuberculosis
Antimicrobial activity of clofazimine is not dependent on mycobacterial C-type phospholipases.
Tuberculosis
Biochemical and genetic evidence for phospholipase C activity in Mycobacterium ulcerans.
Tuberculosis
Biochemical and molecular analysis of phospholipase C and phospholipase D activity in mycobacteria.
Tuberculosis
Detection of phospholipase C in nontuberculous mycobacteria and its possible role in hemolytic activity.
Tuberculosis
Determination of the minimal acid-inducible promoter region of the lipF gene from Mycobacterium tuberculosis.
Tuberculosis
Distribution of insertion- and deletion-associated genetic polymorphisms among four Mycobacterium tuberculosis phospholipase C genes and associations with extrathoracic tuberculosis: a population-based study.
Tuberculosis
Effect of serial subculturing on the genetic composition and cytotoxic activity of Mycobacterium tuberculosis.
Tuberculosis
Evaluation of Mycobacterium tuberculosis genes involved in resistance to killing by human macrophages.
Tuberculosis
Evidence for the cytotoxic effects of Mycobacterium tuberculosis phospholipase C towards macrophages.
Tuberculosis
Evidence for the expression of native Mycobacterium tuberculosis phospholipase C: recognition by immune sera and detection of promoter activity.
Tuberculosis
Expression and characterization of the carboxyl esterase Rv3487c from Mycobacterium tuberculosis.
Tuberculosis
Functional characterization of the phospholipase C activity of Rv3487c and its localization on the cell wall of Mycobacterium tuberculosis.
Tuberculosis
Human CD8+ T cells recognize epitopes of the 28-kDa hemolysin and the 38-kDa antigen of Mycobacterium tuberculosis.
Tuberculosis
Identification of an IS6110 insertion site in plcD, the unique phospholipase C gene of Mycobacterium bovis.
Tuberculosis
Identification of functional Tat signal sequences in Mycobacterium tuberculosis proteins.
Tuberculosis
Identification of one insertion site of IS6110 in Mycobacterium tuberculosis H37Ra and analysis of the RvD2 deletion in M. tuberculosis clinical isolates.
Tuberculosis
Insertion- and deletion-associated genetic diversity of Mycobacterium tuberculosis phospholipase C-encoding genes among 106 clinical isolates from Turkey.
Tuberculosis
Molecular characteristics of strains of the cameroon family, the major group of Mycobacterium tuberculosis in a country with a high prevalence of tuberculosis.
Tuberculosis
Molecular characteristics of the Mycobacterium tuberculosis LAM-RUS family prevalent in Central Russia.
Tuberculosis
Molecular characterization of tlyA gene product, Rv1694 of Mycobacterium tuberculosis: a non-conventional hemolysin and a ribosomal RNA methyl transferase.
Tuberculosis
Mycobacterium tuberculosis expressing phospholipase C subverts PGE2 synthesis and induces necrosis in alveolar macrophages.
Tuberculosis
Phospholipase region of Mycobacterium tuberculosis is a preferential locus for IS6110 transposition.
Tuberculosis
Protective efficacy against tuberculosis of ESAT-6 secreted by a live Salmonella typhimurium vaccine carrier strain and expressed by naked DNA.
Tuberculosis
The twin-arginine translocation pathway of Mycobacterium smegmatis is functional and required for the export of mycobacterial beta-lactamases.
Tuberculosis
Use of a colorimetric assay to measure differences in cytotoxicity of Mycobacterium tuberculosis strains.
Tuberculosis
Using polymerase chain reaction with primers based on the plcB-plcC intergenic region to detect Mycobacterium tuberculosis in clinical samples.
Typhoid Fever
Delineation of B-cell Epitopes of Salmonella enterica serovar Typhi Hemolysin E: Potential antibody therapeutic target.
Typhoid Fever
Evaluation of a Rapid Point-of-Care Multiplex Immunochromatographic Assay for the Diagnosis of Enteric Fever.
Typhoid Fever
Multi-isotype antibody responses against the multimeric Salmonella Typhi recombinant hemolysin E antigen.
Typhoid Fever
Serodiagnosis of Acute Typhoid Fever in Nigerian Pediatric Cases by Detection of Serum IgA and IgG Against Hemolysin E and Lipopolysaccharide.
Urinary Bladder Neoplasms
Re: Cheng et al.: shRNA targeting PLC inhibits bladder cancer cell growth in vitro and in vivo (Urology 2011;78:474e.7-474e.11).
Urinary Bladder Neoplasms
Tamoxifen-induced Ca2+ mobilization in bladder female transitional carcinoma cells.
Urinary Bladder, Neurogenic
Expression of virulence factors among Escherichia coli isolated from the periurethra and urine of children with neurogenic bladder on intermittent catheterization.
Urinary Tract Infections
Antibodies Against Hemolysin and Cytotoxic Necrotizing Type 1 (CNF1) Reduce Bladder Inflammation in a Mouse Model of Urinary Tract Infection with Toxigenic Uropathogenic Escherichia coli.
Urinary Tract Infections
Biofilm formation in uropathogenic Escherichia coli strains: relationship with prostatitis, urovirulence factors and antimicrobial resistance.
Urinary Tract Infections
Biological and genetic characteristics of uropathogenic Escherichia coli strains.
Urinary Tract Infections
Cloned hemolysin genes from Escherichia coli that cause urinary tract infection determine different levels of toxicity in mice.
Urinary Tract Infections
Complex Multilevel Control of Hemolysin Production by Uropathogenic Escherichia coli.
Urinary Tract Infections
Construction of a flagellum-negative mutant of Proteus mirabilis: effect on internalization by human renal epithelial cells and virulence in a mouse model of ascending urinary tract infection.
Urinary Tract Infections
Gene block encoding production of cytotoxic necrotizing factor 1 and hemolysin in Escherichia coli isolates from extraintestinal infections.
Urinary Tract Infections
Gene clusters governing the production of hemolysin and mannose-resistant hemagglutination are closely linked in Escherichia coli serotype O4 and O6 isolates from urinary tract infections.
Urinary Tract Infections
Hemolysin production as a virulence marker in symptomatic and asymptomatic urinary tract infections caused by Escherichia coli.
Urinary Tract Infections
Hemolysis due to Alpha-Hemolytic Enterococcus Urinary Infection: A Rare Cause of Early and Severe Unconjugated Hyperbilirubinemia in a Neonate.
Urinary Tract Infections
Hemolytic Escherichia coli strains in the human fecal flora as potential urinary pathogens.
Urinary Tract Infections
Identification of virulence genes in uropathogenic Escherichia coli by multiplex polymerase chain reaction and their association with infectivity in mice.
Urinary Tract Infections
K-antigen identification, hemolysin production, and hemagglutination types of Escherichia coli O6 strains isolated from patients with urinary tract infections.
Urinary Tract Infections
Lack of association between hemolysin production and acute inflammation in human urinary tract infection.
Urinary Tract Infections
Molecular cloning and physical characterization of a chromosomal hemolysin from Escherichia coli.
Urinary Tract Infections
Occurrence of genes for P and S fimbriae and hemolysin in urinary Escherichia coli.
Urinary Tract Infections
Quercetin inhibits swarming motility and activates biofilm production of Proteus mirabilis possibly by interacting with central regulators, metabolic status or active pump proteins.
Urinary Tract Infections
Serotype, hemolysin production, and adherence characteristics of strains of Escherichia coli causing urinary tract infection in dogs.
Urinary Tract Infections
Serum resistance among Escherichia coli strains causing urinary tract infection in relation to O type and the carriage of hemolysin, colicin, and antibiotic resistance determinants.
Urinary Tract Infections
The cell-bound hemolysin of Serratia marcescens contributes to uropathogenicity.
Urinary Tract Infections
The Extracellular Domain of the ?2 Integrin ? Subunit (CD18) Is Sufficient for Escherichia coli Hemolysin and Aggregatibacter actinomycetemcomitans Leukotoxin Cytotoxic Activity.
Urinary Tract Infections
Urovirulence determinants in Escherichia coli isolates causing first-episode and recurrent cystitis in women.
Urinary Tract Infections
Virulence characteristics of Escherichia coli in relation to host response in men with symptomatic urinary tract infection.
Urinary Tract Infections
Virulence determinants of uropathogenic Escherichia coli and Proteus mirabilis.
Urinary Tract Infections
Virulence factors of uropathogenic Escherichia coli from a university hospital in Ribeirão Preto, São Paulo, Brazil.
Urinary Tract Infections
Virulence genes and P fimbriae PapA subunit diversity in canine and feline uropathogenic Escherichia coli.
Urinary Tract Infections
Virulence-associated characteristics of Escherichia coli in urinary tract infection: a statistical analysis with special attention to type 1C fimbriation.
Urinary Tract Infections
[Experimental urinary tract infection caused by Escherichia coli in diabetic mouse--uroepithelial colonization and polymorphonuclear leukocyte function]
Urinary Tract Infections
[Frequency of colicin and hemolysins in Escherichia coli isolated from pregnant patients with urinary tract infection, symptomatic and asymptomatic]
Urogenital Neoplasms
Solitary Pulmonary Lesion in Patients with History of Malignancy: Primary Lung Cancer or Metastatic Cancer?
Urologic Diseases
[Persistense of mono- and associated cultures of conditionally pathogenic enterobacteria]
Urticaria
A hypermorphic missense mutation in PLCG2, encoding phospholipase C?2, causes a dominantly inherited autoinflammatory disease with immunodeficiency.
Urticaria
Association study of genetic variants in PLA2G4A, PLCG1, LAT, SYK, and TNFRS11A genes in NSAIDs-induced urticaria and/or angioedema patients.
Urticaria
Functional characterization of phospholipase C-?2 mutant protein causing both somatic ibrutinib resistance and a germline monogenic autoinflammatory disorder.
Urticaria
[A new auto-inflammatory genetic disease associated with cold urticaria: Plaid involving PLCG2 mutation].
Uterine Cervical Neoplasms
Differential osmosensing signalling pathways and G-protein involvement in human cervical cells with different tumour potential.
Uveitis
Inhibition of experimental melanin protein-induced uveitis (EMIU) by targeting nitric oxide via phosphatidylcholine-specific phospholipase C.
Uveitis
The use of ultra wide field fluorescein angiography in evaluation and management of uveitis.
Vaccinia
Immune responses of mice to vaccinia virus recombinants expressing either Listeria monocytogenes partial listeriolysin or Brucella abortus ribosomal L7/L12 protein.
Vaccinia
Inhibition of agonist-induced activation of phospholipase C following poxvirus infection.
Vaginitis
Immunoglobulin A response against Gardnerella vaginalis hemolysin and sialidase activity in bacterial vaginosis.
Vaginosis, Bacterial
Correlation of local interleukin-1beta levels with specific IgA response against Gardnerella vaginalis cytolysin in women with bacterial vaginosis.
Vaginosis, Bacterial
Correlation of local interleukin-8 with immunoglobulin A against Gardnerella vaginalis hemolysin and with prolidase and sialidase levels in women with bacterial vaginosis.
Vaginosis, Bacterial
Immunoglobulin A response against Gardnerella vaginalis hemolysin and sialidase activity in bacterial vaginosis.
Vaginosis, Bacterial
Specific immune response against Gardnerella vaginalis hemolysin in patients with bacterial vaginosis.
Vascular System Injuries
Leukotriene and hydroxyeicosatetraenoic acid generation elicited by low doses of Escherichia coli hemolysin in rabbit lungs.
Vascular System Injuries
The Pathoanatomy of Posterolateral Corner Ligamentous Disruption in Multiligament Knee Injuries Is Predictive of Peroneal Nerve Injury.
Vasculitis
Acute autoimmune hemolytic anemia due to a low molecular weight IgM cold hemolysin associated with episodic lymphoid granulomatous vasculitis.
Vasospasm, Intracranial
Evidence for the role of phosphatidylcholine-specific phospholipase in experimental subarachnoid hemorrhage in rats.
Vasospasm, Intracranial
Modulatory role of protein tyrosine kinase activation in the receptor-induced contractions of the bovine cerebral artery.
Venous Thromboembolism
Platelet count and the risk of bleeding in hospitalized patients with venous thromboembolism starting anticoagulant therapy.
Ventricular Dysfunction
Inhibition of sarcoplasmic reticulum calcium release reduces myocardial stunning.
Ventricular Fibrillation
Leukotriene-mediated coronary vasoconstriction and loss of myocardial contractility evoked by low doses of Escherichia coli hemolysin in perfused rat hearts.
Ventricular Fibrillation
Metabolically controlled reperfusion in acute myocardial infarction: should the polarizing solution be given subselectively?
Vesicular Stomatitis
A synthetic peptide corresponding to the NH2 terminus of vesicular stomatitis virus glycoprotein is a pH-dependent hemolysin.
Vesicular Stomatitis
Autophagy and innate immunity: Insights from invertebrate model organisms.
Vesicular Stomatitis
Biologically active peptides of the vesicular stomatitis virus glycoprotein.
Vesicular Stomatitis
Cell-membrane phospholipase C is involved in inducing the antiviral effect of interferon.
Vesicular Stomatitis
Effect of phospholipase C and cholesterol oxidase on membrane integrity, microviscosity, and infectivity of vesicular stomatitis virus.
Vibrio Infections
A case-control analysis of traceback investigations for Vibrio parahaemolyticus infections (vibriosis) and pre-harvest environmental conditions in Washington State, 2013-2018.
Vibrio Infections
Cloning and expression of gene encoding the thermostable direct hemolysin from Vibrio alginolyticus strain HY9901, the causative agent of vibriosis of crimson snapper (Lutjanus erythopterus).
Virus Diseases
Dynamics of Major Histocompatibility Complex Class I Association with the Human Peptide-loading Complex.
Virus Diseases
Identification of key genes and pathways associated with classical Hodgkin lymphoma by bioinformatics analysis.
Virus Diseases
Inhibition of agonist-induced activation of phospholipase C following poxvirus infection.
Virus Diseases
Liver Cancer in Viet Nam: Risk Estimates of Viral Infections and Dioxin Exposure in the South and North Populations.
Virus Diseases
PCV2 Triggers PK-15 Cell Apoptosis Through the PLC-IP3R-Ca2+ Signaling Pathway.
Virus Diseases
Phospholipase C signaling is involved in porcine reproductive and respiratory syndrome virus infection in cell cultures.
Virus Diseases
[Method of adaptation of the Kolmer values in determination of hemolysin with the complement fixation test in virus diseases. Practical note]
Vulvovaginitis
Evaluation of esterase and hemolysin activities of different Candida species isolated from vulvovaginitis cases in Lorestan Province, Iran.
Vulvovaginitis
Itraconazole-resistant Candida auris with phospholipase, proteinase and hemolysin activity from a case of vulvovaginitis.
Warts
Imiquimod versus podophyllotoxin, with and without human papillomavirus vaccine, for anogenital warts: the HIPvac factorial RCT.
Whooping Cough
1-Fluoro-2,4-dinitrobenzene and its derivatives act as secretagogues on rodent mast cells.
Whooping Cough
12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids.
Whooping Cough
5-Hydroxytryptamine induces phospholipase C-mediated hydrolysis of phosphoinositides through 5-hydroxytryptamine-2 receptors in cultured fetal mouse ventricular myocytes.
Whooping Cough
5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein-coupled receptor D.
Whooping Cough
A C-terminal mutant of the G protein beta subunit deficient in the activation of phospholipase C-beta.
Whooping Cough
A cathelicidin family of human antibacterial peptide LL-37 induces mast cell chemotaxis.
Whooping Cough
A comparative study of endothelin- and platelet-activating-factor-mediated signal transduction and prostaglandin synthesis in rat Kupffer cells.
Whooping Cough
A defect late in stimulus-secretion coupling impairs insulin secretion in Goto-Kakizaki diabetic rats.
Whooping Cough
A G protein-coupled ?7 nicotinic receptor regulates signaling and TNF-? release in microglia.
Whooping Cough
A Gq-type G protein couples muscarinic receptors to inositol phosphate and calcium signaling in exocrine cells from the avian salt gland.
Whooping Cough
A molecularly identified P2Y receptor simultaneously activates phospholipase C and inhibits adenylyl cyclase and is nonselectively activated by all nucleoside triphosphates.
Whooping Cough
A new assay for invasion of HeLa 229 cells by Bordetella pertussis: effects of inhibitors, phenotypic modulation, and genetic alterations.
Whooping Cough
A novel antimicrobial peptide isolated from centipede Scolopendra subspinipes mutilans stimulates neutrophil activity through formyl peptide receptor 2.
Whooping Cough
A novel collagen-binding peptide promotes osteogenic differentiation via Ca(2+)/calmodulin-dependent protein kinase II/ERK/AP-1 signaling pathway in human bone marrow-derived mesenchymal stem cells.
Whooping Cough
A peptide with unique receptor specificity: stimulation of phosphoinositide hydrolysis and induction of superoxide generation in human neutrophils.
Whooping Cough
A pertussis toxin-sensitive G protein is required to induce histamine release from rat peritoneal mast cells by bradykinin.
Whooping Cough
A pertussis toxin-sensitive GTP-binding protein couples endothelin to phospholipase C in rat mesangial cells.
Whooping Cough
A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1.
Whooping Cough
A single species of A1 adenosine receptor expressed in Chinese hamster ovary cells not only inhibits cAMP accumulation but also stimulates phospholipase C and arachidonate release.
Whooping Cough
A slowly ADP-ribosylated pertussis-toxin-sensitive GTP-binding regulatory protein is required for vasopressin-stimulated Ca2+ inflow in hepatocytes.
Whooping Cough
Actions of cyclic adenosine monophosphate on the cytodifferentiation of ovarian cells: studies in cultured swine granulosa cells using a novel exogenous adenylate cyclase from Bordetella pertussis.
Whooping Cough
Activation of a phosphatidylcholine-specific phospholipase C by colony stimulating factor 1 receptor requires tyrosine phosphorylation and a guanine nucleotide-binding protein.
Whooping Cough
Activation of beta-adrenergic receptors inhibits Ca2+ entry-mediated generation of inositol phosphates in the guinea pig myometrium, a cyclic AMP-independent event.
Whooping Cough
Activation of cytosolic phosphoinositide phospholipase C by G-protein beta gamma subunits.
Whooping Cough
Activation of group I metabotropic glutamate receptors induces long-term depression at sensory synapses in superficial spinal dorsal horn.
Whooping Cough
Activation of human monocytes by a formyl peptide receptor 2-derived pepducin.
Whooping Cough
Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate.
Whooping Cough
Activation of inositol phospholipid breakdown in HL60 cells by P2-purinergic receptors for extracellular ATP. Evidence for mediation by both pertussis toxin-sensitive and pertussis toxin-insensitive mechanisms.
Whooping Cough
Activation of inositol phospholipid-specific phospholipase C by P2-purinergic receptors in human phagocytic leukocytes. Role of pertussis toxin-sensitive G proteins.
Whooping Cough
Activation of muscarinic m5 receptors inhibits recombinant KCNQ2/KCNQ3 K+ channels expressed in HEK293T cells.
Whooping Cough
Activation of p38 mitogen-activated protein kinase by oxidized LDL in vascular smooth muscle cells: mediation via pertussis toxin-sensitive G proteins and association with oxidized LDL-induced cytotoxicity.
Whooping Cough
Activation of phospholipase C by heat shock requires GTP analogs and is resistant to pertussis toxin.
Whooping Cough
Activation of phospholipase C via adenosine receptors provides synergistic signals for secretion in antigen-stimulated RBL-2H3 cells. Evidence for a novel adenosine receptor.
Whooping Cough
Activation of PtdIns(4,5)P2-sensitive phospholipase C in rabbit tracheal epithelial cells.
Whooping Cough
Acute inhibition of the betaine transporter by ATP and adenosine in renal MDCK cells.
Whooping Cough
Adaptive responses of human monocytes infected by bordetella pertussis: the role of adenylate cyclase hemolysin.
Whooping Cough
Age-related alterations in the signal transduction pathways of the elastin-laminin receptor.
Whooping Cough
Agonist-mediated downregulation of G alpha i via the alpha 2-adrenergic receptor is targeted by receptor-Gi interaction and is independent of receptor signaling and regulation.
Whooping Cough
Alpha 1-adrenergic receptor coupling with phospholipase-C is negatively regulated by protein kinase-C in primary cultures of hypothalamic neurons and glial cells.
Whooping Cough
Alpha 2-adrenergic receptors activate phospholipase C in renal epithelial cells.
Whooping Cough
Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G protein of receptor-regulated K+ channels.
Whooping Cough
Alpha-1 adrenergic stimulation of 1,4,5-inositol trisphosphate formation in ventricular myocytes.
Whooping Cough
Ammonium triggers calcium elevation in cultured mouse microglial cells by initiating Ca(2+) release from thapsigargin-sensitive intracellular stores.
Whooping Cough
An antimicrobial peptide tachyplesin acts as a secondary secretagogue and amplifies lipopolysaccharide-induced hemocyte exocytosis.
Whooping Cough
An antimicrobial peptide with angiogenic properties, AG-30/5C, activates human mast cells through the MAPK and NF-?B pathways.
Whooping Cough
An immunosuppressive agent, FTY720, increases intracellular concentration of calcium ion and induces apoptosis in HL-60.
Whooping Cough
Androgens increase intracellular calcium concentration and inositol 1,4,5-trisphosphate and diacylglycerol formation via a pertussis toxin-sensitive G-protein.
Whooping Cough
Angiotensin II effects on the cytosolic free Ca2+ concentration in N1E-115 neuroblastoma cells: kinetic properties of the Ca2+ transient measured in single fura-2-loaded cells.
Whooping Cough
Angiotensin II stimulation of vascular smooth muscle cells. Secondary signalling mechanisms.
Whooping Cough
Angiotensin II-mediated signal transduction events in cystic fibrosis pancreatic duct cells.
Whooping Cough
Anomalous features of human neutrophil activation by influenza A virus are shared by related viruses and sialic acid-binding lectins.
Whooping Cough
ANP stimulates phospholipase C in cultured RIMCT cells: roles of protein kinases and G protein.
Whooping Cough
Antimicrobial peptides human beta-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability.
Whooping Cough
Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines.
Whooping Cough
Antiproliferative effect of sphingosylphosphorylcholine in thyroid FRO cancer cells mediated by cell cycle arrest in the G2/M phase.
Whooping Cough
Apical and basolateral effects of PTH in OK cells: transport inhibition, messenger production, effects of pertussis toxin, and interaction with a PTH analog.
Whooping Cough
Apolipoprotein CIII-induced THP-1 cell adhesion to endothelial cells involves pertussis toxin-sensitive G protein- and protein kinase C alpha-mediated nuclear factor-kappaB activation.
Whooping Cough
Astrocyte mGlu(2/3)-mediated cAMP potentiation is calcium sensitive: studies in murine neuronal and astrocyte cultures.
Whooping Cough
ATP causes release of intracellular Ca2+ via the phospholipase C beta/IP3 pathway in astrocytes from the dorsal spinal cord.
Whooping Cough
ATP produces potassium currents via P3 purinoceptor in the follicle cell layer of Xenopus oocytes.
Whooping Cough
ATP stimulates secretion in human neutrophils and HL60 cells via a pertussis toxin-sensitive guanine nucleotide-binding protein coupled to phospholipase C.
Whooping Cough
ATP-evoked inositol phosphates formation through activation of P2U purinergic receptors in cultured astrocytes: regulation by PKC subtypes alpha, delta, and theta.
Whooping Cough
Betagamma subunits of pertussis toxin-sensitive G proteins mediate A1 adenosine receptor agonist-induced activation of phospholipase C in collaboration with thyrotropin. A novel stimulatory mechanism through the cross-talk of two types of receptors.
Whooping Cough
Bimodal acute effects of A1 adenosine receptor activation on Na+/H+ exchanger 3 in opossum kidney cells.
Whooping Cough
Binding, coupling, and mRNA subtype heterogeneity of alpha 1-adrenergic receptors in cultured human RPE.
Whooping Cough
Biochemical and functional characterization of high-affinity urotensin II receptors in rat cortical astrocytes.
Whooping Cough
Bombesin activation of phospholipase C beta 1 in rat acinar pancreatic cells involves the pertussis toxin-sensitive G alpha i3 protein.
Whooping Cough
Bordetella pertussis adenylate cyclase toxin and hemolytic activities require a second gene, cyaC, for activation.
Whooping Cough
Bradykinin B2 receptors activate Na+/H+ exchange in mIMCD-3 cells via Janus kinase 2 and Ca2+/calmodulin.
Whooping Cough
Bradykinin stimulation of inositol polyphosphate production in porcine aortic endothelial cells.
Whooping Cough
Bradykinin-activated membrane-associated phospholipase C in Madin-Darby canine kidney cells.
Whooping Cough
C-terminal parathyroid hormone-related protein (PTHrP) (107-139) stimulates intracellular Ca(2+) through a receptor different from the type 1 PTH/PTHrP receptor in osteoblastic osteosarcoma UMR 106 cells.
Whooping Cough
C5a differentially stimulates the ERK1/2 and p38 MAPK phosphorylation through independent signaling pathways to induced chemotactic migration in RAW264.7 macrophages.
Whooping Cough
Ca2+ influx, phosphoinositide hydrolysis, and histamine release induced by lysophosphatidylserine in mast cells.
Whooping Cough
Calcium is necessary but not sufficient for the platelet-activating factor release in human neutrophils stimulated by physiological stimuli. Role of G-proteins.
Whooping Cough
Calcium-sensing receptor modulates extracellular Ca2+ entry via TRPC-encoded receptor-operated channels in human aortic smooth muscle cells.
Whooping Cough
Calcium-sensing receptor-mediated activation of phospholipase C-gamma1 is downstream of phospholipase C-beta and protein kinase C in MC3T3-E1 osteoblasts.
Whooping Cough
Cannabinoid CB1 receptor elevation of intracellular calcium in neuroblastoma SH-SY5Y cells: interactions with muscarinic and delta-opioid receptors.
Whooping Cough
Canonical and non-canonical Wnt signaling are simultaneously activated by Wnts in colon cancer cells.
Whooping Cough
Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines.
Whooping Cough
Cell signaling and estrogens in female rat osteoblasts: a possible involvement of unconventional nonnuclear receptors.
Whooping Cough
Cellular mechanisms of ATP-induced hyperpolarization in renal epitheloid MDCK-cells.
Whooping Cough
Cellular mechanisms of bradykinin-induced hyperpolarization in renal epitheloid MDCK-cells.
Whooping Cough
Characterization of adenosine A1 receptor in a cell line (28A) derived from rabbit collecting tubule.
Whooping Cough
Characterization of fMet-Leu-Phe-stimulated phospholipase C in streptolysin-O-permeabilised cells.
Whooping Cough
Characterization of ghrelin receptor activity in a rat pituitary cell line RC-4B/C.
Whooping Cough
Characterization of lysophosphatidic acid and sphingosine-1-phosphate-mediated signal transduction in rat cortical oligodendrocytes.
Whooping Cough
Characterization of muscarinic receptor-mediated cationic currents in longitudinal smooth muscle cells of mouse small intestine.
Whooping Cough
Characterization of phagocyte P2 nucleotide receptors expressed in Xenopus oocytes.
Whooping Cough
Characterization of Post-Translational Modifications and Cytotoxic Properties of the Adenylate-Cyclase Hemolysin Produced by Various Bordetella pertussis and Bordetella parapertussis Isolates.
Whooping Cough
Characterization of signaling pathways of P2Y and P2U purinoceptors in bovine pulmonary artery endothelial cells.
Whooping Cough
Characterization of sphingosine 1-phosphate-induced actions and its signaling pathways in rat hepatocytes.
Whooping Cough
Chemical cross-linking of the substance P (NK-1) receptor to the alpha subunits of the G proteins Gq and G11.
Whooping Cough
Chemokine-directed trafficking of receptor stimulus to different g proteins: selective inducible and constitutive signaling by human herpesvirus 6-encoded chemokine receptor u51.
Whooping Cough
Chemotactic peptide activation of human neutrophils and HL-60 cells. Pertussis toxin reveals correlation between inositol trisphosphate generation, calcium ion transients, and cellular activation.
Whooping Cough
Chemotactic peptide, calcium and guanine nucleotide regulation of phospholipase C activity in membranes from DMSO-differentiated HL60 cells.
Whooping Cough
Chimeric muscarinic cholinergic:beta-adrenergic receptors that are functionally promiscuous among G proteins.
Whooping Cough
Cholera toxin modulation of angiotensin II-stimulated inositol phosphate production in cultured vascular smooth muscle cells.
Whooping Cough
Cholinergic modulation of the Ca2+ response to bradykinin in neuroblastoma cells.
Whooping Cough
Cholinergic-induced [3H] noradrenaline release in rat brain cortical slices is mediated via a pertussis toxin sensitive GTP binding protein and involves activation of protein kinase C.
Whooping Cough
Cholinoceptor activation subserving the effects of interferon gamma on the contractility of rat ileum.
Whooping Cough
Co-expression of a Ca2+-inhibitable adenylyl cyclase and of a Ca2+-sensing receptor in the cortical thick ascending limb cell of the rat kidney. Inhibition of hormone-dependent cAMP accumulation by extracellular Ca2+.
Whooping Cough
Coincidence detection at the level of phospholipase C activation mediated by the m4 muscarinic acetylcholine receptor.
Whooping Cough
Collagen type IV stimulates an increase in intracellular Ca2+ in pancreatic acinar cells via activation of phospholipase C.
Whooping Cough
Comparison of extracellular ATP and UTP signalling in rat renal mesangial cells. No indications for the involvement of separate purino- and pyrimidino-ceptors.
Whooping Cough
Conformational dependence of collagenase (matrix metalloproteinase-1) up-regulation by elastin peptides in cultured fibroblasts.
Whooping Cough
Conserved transducer coupling but different effector linkage upon expression of the myeloid fMet-Leu-Phe receptor in insulin secreting cells.
Whooping Cough
Constitutive inositol phosphate formation in cytomegalovirus-infected human fibroblasts is due to expression of the chemokine receptor homologue pUS28.
Whooping Cough
Coupling between phosphoinositide breakdown and early mitogenic events in fibroblasts. Studies with fluoroaluminate, vanadate, and pertussis toxin.
Whooping Cough
Coupling function of endogenous alpha(1)- and beta-adrenergic receptors in mouse cardiomyocytes.
Whooping Cough
Coupling of exogenous receptors to phospholipase C in Xenopus oocytes through pertussis toxin-sensitive and -insensitive pathways. Cross-talk through heterotrimeric G-proteins.
Whooping Cough
Critical Signaling Events in the Mechanoactivation of Human Mast Cells through p.C492Y-ADGRE2.
Whooping Cough
Cysteine residues in the carboxyl terminal domain of the endothelin-B receptor are required for coupling with G-proteins.
Whooping Cough
Cytosolic phospholipase C activity: I. Evidence for coupling with cytosolic guanine nucleotide-binding protein, Gi alpha.
Whooping Cough
Delta opiate receptors account for the castration-induced unmasking of gonadotropin-releasing hormone binding sites in the rat pituitary.
Whooping Cough
Deregulation of hamster fibroblast proliferation by mutated ras oncogenes is not mediated by constitutive activation of phosphoinositide-specific phospholipase C.
Whooping Cough
Development of muscarinic-cholinergic stimulation of inositol phosphate production in cultured embryonic chick atrial cells. Evidence for a switch in guanine-nucleotide-binding protein coupling.
Whooping Cough
Diacylglycerol production induced by growth hormone in Ob1771 preadipocytes arises from phosphatidylcholine breakdown.
Whooping Cough
Different concentrations of pertussis toxin have opposite effects on agonist-induced PGE2 formation in mesangial cells.
Whooping Cough
Different endothelin receptor subtypes are involved in phospholipid signalling in the proximal tubule of rat kidney.
Whooping Cough
Different guanosine triphosphate-binding proteins couple vasopressin receptor to phospholipase C and phospholipase A2 in glomerular mesangial cells.
Whooping Cough
Different mechanisms are involved in intracellular calcium increase by insulin-like growth factors 1 and 2 in articular chondrocytes: voltage-gated calcium channels, and/or phospholipase C coupled to a pertussis-sensitive G-protein.
Whooping Cough
Different sensitivity to phorbol esters and pertussis toxin of bombesin- and platelet-derived growth factor-induced, phospholipase C-mediated hydrolysis of phosphoinositides in NIH/3T3 cells.
Whooping Cough
Differential CCR1-mediated chemotaxis signaling induced by human CC chemokine HCC-4/CCL16 in HOS cells.
Whooping Cough
Differential coupling of the formyl peptide receptor to adenylate cyclase and phospholipase C by the pertussis toxin-insensitive Gz protein.
Whooping Cough
Differential effect of adenosine on rhabdomyosarcoma migration and proliferation.
Whooping Cough
Differential phospholipase D activation by bradykinin and sphingosine 1-phosphate in NIH 3T3 fibroblasts overexpressing gelsolin.
Whooping Cough
Differential regulation of 46 and 54 kDa jun N-terminal kinases and p38 mitogen-activated protein kinase by human alpha(1A)-adrenoceptors expressed in Rat-1 cells.
Whooping Cough
Differential regulation of formyl peptide and platelet-activating factor receptors. Role of phospholipase Cbeta3 phosphorylation by protein kinase A.
Whooping Cough
Differential regulation of thrombin- or ATP-induced mobilization of intracellular Ca2+ by prostacyclin receptor in mouse mastocytoma cells.
Whooping Cough
Differential sensitivity of arachidonic acid release and 1,2-diacylglycerol formation to pertussis toxin, GDP beta S and NaF in saponin-permeabilized human platelets: possible evidence for distinct GTP-binding proteins involving phospholipase C and A2 activation.
Whooping Cough
Direct effect of adenosine on prolactin secretion at the level of the single rat lactotroph: involvement of pertussis toxin-sensitive and -insensitive transducing mechanisms.
Whooping Cough
Distinct receptors and different transduction mechanisms for ATP and adenosine at the frog motor nerve endings.
Whooping Cough
Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal.
Whooping Cough
Dual effects of ATP on the potassium channel and intracellular Ca2+ release in smooth muscle cells of the bovine brain arteries.
Whooping Cough
Dual modulation of inward rectifier potassium currents in olfactory neuronal cells by promiscuous G protein coupling of the oxytocin receptor.
Whooping Cough
Dual regulation of cyclic AMP formation by thrombin in HEL cells, a leukaemic cell line with megakaryocytic properties.
Whooping Cough
Dual role of GTP-binding proteins in the control of endothelial prostacyclin.
Whooping Cough
Effect of cellular expression of pleckstrin homology domains on Gi-coupled receptor signaling.
Whooping Cough
Effect of nonhydrolyzable guanosine phosphate on IgE-mediated activation of phospholipase C and histamine release from rodent mast cells.
Whooping Cough
Effect of pertussis toxin and B-oligomer on platelet-activating factor-induced generation of inositol phosphates in porcine alveolar macrophages.
Whooping Cough
Effect of pertussis toxin on the phosphodiesteratic cleavage of the polyphosphoinositides by guanosine 5'-O-thiotriphosphate and thrombin in permeabilized human platelets.
Whooping Cough
Effect of ranakinin, a novel tachykinin, on cytosolic free calcium in frog adrenochromaffin cells.
Whooping Cough
Effects of angiotensin II on the action potential durations of atrial myocytes in hypertensive rats.
Whooping Cough
Effects of ATP on phosphoinositide hydrolysis and prostaglandin E2 generation in rabbit astrocytes.
Whooping Cough
Effects of C-terminal truncation of the recombinant delta-opioid receptor on phospholipase C and adenylyl cyclase coupling.
Whooping Cough
Effects of ECL cell extracts and granule/vesicle-enriched fractions from rat oxyntic mucosa on cAMP and IP(3) in rat osteoblast-like cells.
Whooping Cough
Effects of extracellular nucleotides in the pituitary: adenosine triphosphate receptor-mediated intracellular responses in gonadotrope-derived alpha T3-1 cells.
Whooping Cough
Effects of insulin, pertussis toxin and cholera toxin on protein synthesis and diacylglycerol production in 3T3 fibroblasts: evidence for a G-protein mediated activation of phospholipase C in the insulin signal mechanism.
Whooping Cough
Effects of ras-encoded proteins and platelet-derived growth factor on inositol phospholipid turnover in NRK cells.
Whooping Cough
Efficient neutrophil extracellular trap induction requires mobilization of both intracellular and extracellular calcium pools and is modulated by cyclosporine A.
Whooping Cough
Endocrine disrupting chemical atrazine causes degranulation through Gq/11 protein-coupled neurosteroid receptor in mast cells.
Whooping Cough
Endothelial cell thrombin receptors and PAR-2. Two protease-activated receptors located in a single cellular environment.
Whooping Cough
Endothelin receptor binding and cellular signal transduction in neurohybrid NG108-15 cells.
Whooping Cough
Endothelin receptor is coupled to phospholipase C via a pertussis toxin-insensitive guanine nucleotide-binding regulatory protein in vascular smooth muscle cells.
Whooping Cough
Endothelin receptor type A signals both the accumulation of inositol phosphates and the inhibition of cyclic AMP generation in rat myometrium: stimulation and desensitization.
Whooping Cough
Endothelin receptors and coupled GTP-binding proteins in glomerular mesangial cells.
Whooping Cough
Endothelin-1 stimulates the release of arachidonic acid and prostaglandins in cultured human ciliary muscle cells: activation of phospholipase A2.
Whooping Cough
Endothelin-elicited stimulation of phospholipase C is mediated by guanine nucleotide binding protein(s).
Whooping Cough
Enhanced bradykinin-stimulated phospholipase C activity in murine embryonic stem cells lacking the G-protein alphaq-subunit.
Whooping Cough
Epidermal growth factor activates phospholipase C in rat hepatocytes via a different mechanism from that in A431 or rat1hER cells.
Whooping Cough
Epidermal growth factor activates phospholipase C-gamma 1 via G(i)1-2 proteins in isolated pancreatic acinar membranes.
Whooping Cough
Epidermal growth factor and angiotensin II stimulate formation of inositol 1,4,5- and inositol 1,3,4-trisphosphate in hepatocytes. Differential inhibition by pertussis toxin and phorbol 12-myristate 13-acetate.
Whooping Cough
Epidermal growth factor inhibits bombesin-induced activation of phospholipase C-beta1 in rat pancreatic acinar cells.
Whooping Cough
Epithelial cell-derived human beta-defensin-2 acts as a chemotaxin for mast cells through a pertussis toxin-sensitive and phospholipase C-dependent pathway.
Whooping Cough
Essential role of EP3 subtype in prostaglandin E2-induced adhesion of mouse cultured and peritoneal mast cells to the Arg-Gly-Asp-enriched matrix.
Whooping Cough
ET-1 induced Elevation of intracellular calcium in clonal neuronal and embryonic kidney cells involves endogenous endothelin-A receptors linked to phospholipase C through G?(q/11).
Whooping Cough
Ethanol acts synergistically with a D2 dopamine agonist to cause translocation of protein kinase C.
Whooping Cough
Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells.
Whooping Cough
Evidence for a direct negative coupling between dopamine-D2 receptors and PLC by heterotrimeric Gi1/2 proteins in rat anterior pituitary cell membranes.
Whooping Cough
Evidence for involvement of guanine nucleotide-binding regulatory proteins in the activation of phospholipases by hormones.
Whooping Cough
Evidence for the interaction of mast cell-degranulating peptide with pertussis toxin-sensitive G proteins in mast cells.
Whooping Cough
Evidence that a guanine nucleotide-binding protein linked to a muscarinic receptor inhibits directly phospholipase C.
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Experimental researches on the role of phosphoinositide-specific phospholipase C in 4-hydroxynonenal induced exocytosis.
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Expression of a cloned P2Y purinergic receptor that couples to phospholipase C.
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Expression of protease-activated receptors (PARs) in OLN-93 oligodendroglial cells and mechanism of PAR-1-induced calcium signaling.
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Expression of the mammalian calcium signaling response to Trypanosoma cruzi in Xenopus laevis oocytes.
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Extracellular ATP stimulates three different receptor-signal transduction systems in FRTL-5 thyroid cells. Activation of phospholipase C, and inhibition and activation of adenylate cyclase.
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Extracellular nucleotide-induced [Ca2+]i elevation in rat basilar smooth muscle cells.
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Fingolimod inhibits glutamate release through activation of S1P1 receptors and the G protein ?? subunit-dependent pathway in rat cerebrocortical nerve terminals.
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Fish somatostatin sst3 receptor: comparison of radioligand and GTPgammaS binding, adenylate cyclase and phospholipase C activities reveals different agonist-dependent pharmacological signatures.
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Fluprostenol activates phospholipase C and Ca2+ mobilization in human myometrial cells.
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Functional and structural consequences of chemokine (C-X-C motif) receptor 4 activation with cognate and non-cognate agonists.
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G alpha(q/11) coupled to mammalian phospholipase C beta 3-like enzyme mediates the ginsenoside effect on Ca(2+)-activated Cl(-) current in the Xenopus oocyte.
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G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates.
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G protein expression and second messenger formation in human granulosa cells.
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G protein G alpha q/11 and G alpha i1,2 are activated by pancreastatin receptors in rat liver: studies with GTP-gamma 35S and azido-GTP-alpha-32P.
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G protein subunits and the stimulation of phospholipase C by Gs-and Gi-coupled receptors: Lack of receptor selectivity of Galpha(16) and evidence for a synergic interaction between Gbeta gamma and the alpha subunit of a receptor activated G protein.
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G protein-coupled receptor-induced sensitization of phospholipase C stimulation by receptor tyrosine kinases.
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G protein-independent stimulation of human myocardial phospholipase C by mastoparan.
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G protein-mediated inhibition of phospholipase C activity in a solubilized membrane preparation.
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G proteins and phospholipase C mediate thrombin-induced generation of plasminogen activator inhibitor-1 from vascular smooth muscle cells.
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GABAB receptors are expressed in human aortic smooth muscle cells and regulate the intracellular Ca(2+) concentration.
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GABAB1 and GABAB2 receptor subunits co-expressed in cultured human RPE cells regulate intracellular Ca2+ via Gi/o-protein and phospholipase C pathways.
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Galpha(q/11) and gbetagamma proteins and membrane signaling of calcitriol and estradiol.
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Genetic analysis of a region of the Bordetella pertussis chromosome encoding filamentous hemagglutinin and the pleiotropic regulatory locus vir.
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Gi- and protein kinase C-mediated heterologous potentiation of phospholipase C signaling by G protein-coupled receptors.
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Go protein as signal transducer in the pertussis toxin-sensitive phosphatidylinositol pathway.
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Gonadotropin-releasing hormone receptor initiates multiple signaling pathways by exclusively coupling to G(q/11) proteins.
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Group I secreted PLA2 in the maintenance of human lower esophageal sphincter tone.
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GRP-preferring bombesin receptors increase generation of inositol phosphates and tension in rat myometrium.
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GTP gamma S binding activities were reduced in heavy membrane fraction during desensitization by Ca-mobilizing agonists in human astrocytoma cells.
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GTP gamma S increases thrombin-mediated inositol trisphosphate accumulation in permeabilized human endothelial cells.
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GTP-dependent hydrolysis of phosphatidylinositol-4,5-bisphosphate by soluble phospholipase C from adult human epidermis.
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Guanine nucleotide regulation of phospholipase C activity in permeabilized rabbit neutrophils. Inhibition by pertussis toxin and sensitization to submicromolar calcium concentrations.
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Guanine nucleotide-dependent, pertussis toxin-insensitive regulation of phosphoinositide turnover by bradykinin in bovine pulmonary artery endothelial cells.
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Guanine nucleotides and pertussis toxin alter agonist binding to rat septal V(1)-vasopressin receptors.
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Guanosine 5'-O-(3-thiotriphosphate) and guanosine 5'-O-(2-thiodiphosphate) activate G proteins and potentiate fibroblast growth factor-induced DNA synthesis in hamster fibroblasts.
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Guanosine 5'-O-(3-thiotrisphosphate) potentiates both thrombin- and platelet-derived growth factor-induced inositol phosphate release in permeabilized vascular smooth muscle cells. Signaling mechanisms distinguished by sensitivity to pertussis toxin and phorbol esters.
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Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior.
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Hemoglobin causes release of inositol trisphosphate from vascular smooth muscle.
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High-density lipoprotein increases intracellular calcium levels by releasing calcium from internal stores in human endothelial cells.
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Histamine activates phospholipase C in human airway epithelial cells via a phorbol ester-sensitive pathway.
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Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells.
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Human bronchial epithelial cells express PAR-2 with different sensitivity to thermolysin.
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Human catestatin enhances migration and proliferation of normal human epidermal keratinocytes.
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Hyperactivation of phospholipase C does not support the enhanced proliferation of aortic smooth muscle cells from spontaneously hypertensive rats.
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Identification and characterisation of GPR100 as a novel human G-protein-coupled bradykinin receptor.
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Identification of an essential signaling cascade for mitogen-activated protein kinase activation by angiotensin II in cultured rat vascular smooth muscle cells. Possible requirement of Gq-mediated p21ras activation coupled to a Ca2+/calmodulin-sensitive tyrosine kinase.
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Identification of G protein-coupled receptors potently stimulating migration of human transitional-cell carcinoma cells.
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Identification of novel synthetic peptide showing angiogenic activity in human endothelial cells.
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In the developing hippocampus kainate receptors control the release of GABA from mossy fiber terminals via a metabotropic type of action.
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Inhibition by cyclic AMP of guanine nucleotide-induced activation of phosphoinositide-specific phospholipase C in human platelets.
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Inhibition of atrial natriuretic peptide-induced cGMP accumulation by purinergic agonists in FRTL-5 thyroid cells. Involvement of both pertussis toxin-sensitive and insensitive mechanisms.
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Inhibition of bombesin-induced mitogenesis by pertussis toxin: dissociation from phospholipase C pathway.
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Inhibition of metabotropic glutamate receptor 5 induces cellular stress through pertussis toxin-sensitive G i -proteins in murine BV-2 microglia cells.
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Inhibition of Rho-Kinase Abrogates Migration of Human Transitional Cell Carcinoma Cells: Results of an in vitro Study.
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Inhibitors of diacylglycerol metabolism reduce time to the onset of glutamate release potentation by mGlu7 receptors.
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Innate defense regulator IDR-1018 activates human mast cells through G protein-, phospholipase C-, MAPK- and NF-?B-sensitive pathways.
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Inositol trisphosphate/Ca2+ as messengers of bradykinin B2 and muscarinic acetylcholine m1-m4 receptors in neuroblastoma-derived hybrid cells.
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Interaction of vascular alpha-1 adrenoceptors with multiple signal transduction pathways.
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Interactions between a lymphoma membrane-associated guanosine 5'-triphosphate-binding protein and the cytoskeleton during receptor patching and capping.
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Interactions in platelets between G proteins and the agonists that stimulate phospholipase C and inhibit adenylyl cyclase.
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Interferon-gamma elicits a G-protein-dependent Ca2+ signal in human neutrophils after depletion of intracellular Ca2+ stores.
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Interleukin-8 production induced by the endozepine triakontatetraneuropeptide in human neutrophils: role of calcium and pharmacological investigation of signal transduction pathways.
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Intermolecular cross-talk between the prostaglandin E(2) receptor (EP)(3) subtype and thromboxane A(2) receptor signalling in human erythroleukaemic cells.
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Intracellular cross-talk between receptors coupled to phospholipase C via pertussis toxin sensitive and insensitive G-proteins.
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Intracellular cross-talk between receptors coupled to phospholipase C via pertussis toxin-sensitive and insensitive G-proteins in DDT1MF-2 cells.
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Intracellular cross-talk between thyrotropin receptor and A1 adenosine receptor in regulation of phospholipase C and adenylate cyclase in COS-7 cells transfected with their receptor genes.
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Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes. Cross-talk via trans-activation of the tyrosine kinase c-kit receptor.
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Intrathecal administration of low-dose nociceptin/orphanin FQ induces allodynia via c-Jun N-terminal kinase and monocyte chemoattractant protein-1.
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Involvement of a pertussis toxin-sensitive G protein-coupled phospholipase A2 in agonist-stimulated arachidonic acid release in membranes isolated from bovine iris sphincter smooth muscle.
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Involvement of a pertussis-toxin sensitive G protein in the induction of gene expression by insulin.
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Involvement of a signal transduction mechanism in ATP-induced mucin release from cultured airway goblet cells.
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Involvement of G(q/11) in signal transduction in the mammalian vomeronasal organ.
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Involvement of Gs and Gi proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C.
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Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat.
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Involvement of intermediary metabolites in the pathway of extracellular Ca2+-induced mitogen-activated protein kinase activation in human fibroblasts.
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Involvement of pertussis toxin sensitive GTP binding protein in adenosine triphosphate and thrombin-mediated responses in vascular smooth muscle cells.
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Involvement of pertussis toxin-sensitive GTP-binding protein in prostaglandin F2 alpha- induced phosphoinositide hydrolysis in osteoblast-like cells.
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Involvement of pertussis toxin-sensitive GTP-binding proteins in sphingosine 1-phosphate-induced activation of phospholipase C-Ca2+ system in HL60 leukemia cells.
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Involvement of tyrosine kinase in growth factor-induced phospholipase C activation in NIH3T3 cells.
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Isolation of a fibroblast mutant resistant to Clostridium difficile toxins A and B.
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Isolation of Zn2+ as an endogenous agonist of GPR39 from fetal bovine serum.
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Isozyme-selective stimulation of phospholipase C-beta 2 by G protein beta gamma-subunits.
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Lack of functional complementation between Bordetella pertussis filamentous hemagglutinin and Proteus mirabilis HpmA hemolysin secretion machineries.
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Leukotactin-1-induced ERK activation is mediated via Gi/Go protein/PLC/PKC delta/Ras cascades in HOS cells.
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Leukotactin-1/CCL15 induces cell migration and differentiation of human eosinophilic leukemia EoL-1 cells through PKCdelta activation.
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Leukotriene B4 Receptor Type 2 Accelerates the Healing of Intestinal Lesions by Promoting Epithelial Cell Proliferation.
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Leukotriene D4-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle.
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Ligand- and subtype-selective coupling of human alpha-2 adrenoceptors to Ca++ elevation in Chinese hamster ovary cells.
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Lipoprotein(a) stimulates growth of human mesangial cells and induces activation of phospholipase C via pertussis toxin-sensitive G proteins.
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Luteinizing hormone (LH) drives diverse intracellular calcium second messenger signals in isolated porcine ovarian thecal cells: preferential recruitment of intracellular Ca2+ oscillatory cells by higher concentrations of LH.
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Lysophosphatidic acid augments fibroblast-mediated contraction of released collagen gels.
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Lysophosphatidic acid induced nuclear translocation of nuclear factor-kappaB in Panc-1 cells by mobilizing cytosolic free calcium.
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Lysophosphatidic acid is a mediator of Trp-Lys-Tyr-Met-Val-d-Met-induced calcium influx.
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Lysophosphatidic acid triggers calcium entry through a non-store-operated pathway in human neutrophils.
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Lysophosphatidylcholine activates p38 and p42/44 mitogen-activated protein kinases in monocytic THP-1 cells, but only p38 activation is involved in its stimulated chemotaxis.
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Lysophosphatidylethanolamine increases intracellular Ca(2+) through LPA(1) in PC-12 neuronal cells.
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Lysophosphatidylserine induces calcium signaling through Ki16425/VPC32183-sensitive GPCR in bone marrow-derived mast cells and in C6 glioma and colon cancer cells.
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Lysophosphatidylserine Stimulates L2071 Mouse Fibroblast Chemotactic Migration via a Process Involving Pertussis Toxin-Sensitive Trimeric G-Proteins.
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Mastoparan elicits prostaglandin E2 generation and inhibits inositol phosphate accumulation via different mechanisms in rabbit astrocytes.
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Mastoparan, a wasp venom peptide, identifies two discrete mechanisms for elevating cytosolic calcium and inositol trisphosphates in human polymorphonuclear leukocytes.
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MCP-1 receptor binding affinity is up-regulated by pre-stimulation with MCP-1 in an actin polymerization-dependent manner.
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Mechanism of prostaglandin E2-induced arachidonic acid release in osteoblast-like cells: independence from phosphoinositide hydrolysis.
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Mechanisms of calcium mobilization and phosphoinositide hydrolysis in human bronchial smooth muscle cells by endothelin 1.
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Mechanisms of platelet activation: thromboxane A2 as an amplifying signal for other agonists.
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Mechanisms of protein kinase D activation in response to P2Y(2) and P2X7 receptors in primary astrocytes.
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Mechanisms underlying extracellular ATP-evoked interleukin-6 release in mouse microglial cell line, MG-5.
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Mediation by protein kinases C and A of Go-linked slow responses of enteric neurons to 5-HT.
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Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)-coupled pathways.
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Melanin-concentrating hormone reduces somatolactin release from cultured goldfish pituitary cells.
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Melatonin generates an outward potassium current in rat suprachiasmatic nucleus neurones in vitro independent of their circadian rhythm.
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Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells.
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Membrane coordination of receptors and channels mediating the inhibition of neuronal ion currents by ADP.
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Membrane electrical activity elicits inositol 1,4,5-trisphosphate-dependent slow Ca2+ signals through a Gbetagamma/phosphatidylinositol 3-kinase gamma pathway in skeletal myotubes.
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Membrane signalling and progesterone in female and male osteoblasts. I. Involvement Of intracellular Ca(2+), inositol trisphosphate, and diacylglycerol, but not cAMP.
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Metabotropic glutamate receptor activation enhances the activities of two types of Ca2+-activated k+ channels in rat hippocampal astrocytes.
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Metabotropic glutamate receptor analogues inhibit p[NH]ppG-stimulated phospholipase C activity in bovine brain coated vesicles: involvement of a pertussis toxin-sensitive G-protein.
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Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction.
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Metabotropic neurosteroid/sigma-receptor involved in stimulation of nociceptor endings of mice.
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Mitogen-induced activation of Na+/H+ exchange in vascular smooth muscle cells involves janus kinase 2 and Ca2+/calmodulin.
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Mitogenic signaling via endogenous kappa-opioid receptors in C6 glioma cells: evidence for the involvement of protein kinase C and the mitogen-activated protein kinase signaling cascade.
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Mobilization of intracellular Ca2+ and stimulation of cyclic AMP production by kappa opioid receptors expressed in Xenopus oocytes.
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Modulation of bradykinin-induced inositol trisphosphate release in a novel neuroblastoma x dorsal root ganglion sensory neuron cell line (F-11).
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Modulation of cyclic AMP accumulation in glial cells by exogenous phospholipase C.
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Modulation of muscarinic receptor-mediated adenylate cyclase and phospholipase C responses in rat retina.
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Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor.
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Molecular mechanisms for alpha2-adrenoceptor-mediated regulation of synoviocyte populations.
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mu-Opioid receptor stimulation of inositol (1,4,5)trisphosphate formation via a pertussis toxin-sensitive G protein.
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Mu-opioids activate phospholipase C in SH-SY5Y human neuroblastoma cells via calcium-channel opening.
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Multiple polyphosphoinositide pathways regulate apoptotic signalling in a dorsal root ganglion derived cell line.
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Multiple receptor activation elicits synergistic IP formation in nonpigmented ciliary body epithelial cells.
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Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells.
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Murine model for pertussis vaccine encephalopathy: role of the major histocompatibility complex; antibody to albumin and to Bordetella pertussis and pertussis toxin.
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Muscarinic cholinergic stimulation of inositol phosphate production in cultured embryonic chick atrial cells. Evidence for a role of two guanine-nucleotide-binding proteins.
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Muscarinic receptor-dependent activation of phospholipase C in human fetal central nervous system organotypic tissue culture.
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Mycoplasma hyopneumoniae increases intracellular calcium release in porcine ciliated tracheal cells.
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Na+ regulation of formyl peptide receptor-mediated signal transduction in HL 60 cells. Evidence that the cation prevents activation of the G-protein by unoccupied receptors.
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Neisseria meningitidis produces iron-regulated proteins related to the RTX family of exoproteins.
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Nociceptin/orphanin FQ activates mitogen-activated protein kinase in Chinese hamster ovary cells expressing opioid receptor-like receptor.
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Nocistatin and prepro-nociceptin/orphanin FQ 160-187 cause nociception through activation of Gi/o in capsaicin-sensitive and of Gs in capsaicin-insensitive nociceptors, respectively.
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Non-additive potentiation of glutamate release by phorbol esters and metabotropic mGlu7 receptor in cerebrocortical nerve terminals.
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Non-neuronal release of ATP and inositol 1,4,5-trisphosphate accumulation evoked by P2- and M-receptor stimulation in guinea pig ileal segments.
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Nongenomic effects of an anti-idiotypic antibody as an estrogen mimetic in female human and rat osteoblasts.
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Noradrenaline and alpha-adrenergic signaling induce the hsp70 gene promoter in mollusc immune cells.
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Novel model of integration of signaling pathways in rat pancreatic acinar cells.
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Nucleotide-, chemotactic peptide- and phorbol ester-induced exocytosis in HL-60 leukemic cells.
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On the mechanism of action of dexamethasone in a rat mast cell line (RBL-2H3 cells). Evidence for altered coupling of receptors and G-proteins.
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ONO NT-126 is a potent and selective thromboxane A2 antagonist in human astrocytoma cells.
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P2 purinoceptors in cultured bovine middle cerebral artery endothelial cells.
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P2-purinergic receptors in vascular endothelial cells: from concept to reality.
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P2-purinoceptor-mediated formation of inositol phosphates and intracellular Ca2+ transients in human coronary artery smooth muscle cells.
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P2X7 and P2Y13 purinergic receptors mediate intracellular calcium responses to BzATP in rat cerebellar astrocytes.
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P2Y purinoceptor activation mobilizes intracellular Ca2+ and induces a membrane current in rat intracardiac neurones.
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P2Y(13) receptor is responsible for ADP-mediated degranulation in RBL-2H3 rat mast cells.
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Palmitoylation of human endothelinB. Its critical role in G protein coupling and a differential requirement for the cytoplasmic tail by G protein subtypes.
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Pancreastatin activates pertussis toxin-sensitive guanylate cyclase and pertussis toxin-insensitive phospholipase C in rat liver membranes.
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Pasteurella (Mannheimia) haemolytica leukotoxin-induced cytolysis of bovine leukocytes: role of arachidonic acid and its regulation.
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Pasteurella haemolytica A1-derived leukotoxin and endotoxin induce intracellular calcium elevation in bovine alveolar macrophages by different signaling pathways.
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Permissive stimulation of Ca(2+)-induced phospholipase A2 by an adenosine receptor agonist in a pertussis toxin-sensitive manner in FRTL-5 thyroid cells: a new 'cross-talk' mechanism in Ca2+ signalling.
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Pertussis toxin and extracytoplasmic adenylate cyclase as virulence factors of Bordetella pertussis.
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Pertussis toxin B-subunit-induced Ca2(+)-fluxes in Jurkat human lymphoma cells: the action of long-term pre-treatment with cholera and pertussis holotoxins.
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Pertussis toxin can activate human platelets. Comparative effects of holotoxin and its ADP-ribosylating S1 subunit.
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Pertussis toxin inhibits chemotactic factor-induced phospholipase C stimulation and lysosomal enzyme secretion in rabbit neutrophils.
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Pertussis toxin inhibits phospholipase C activation and Ca2+ mobilization by sphingosylphosphorylcholine and galactosylsphingosine in HL60 leukemia cells. Implications of GTP-binding protein-coupled receptors for lysosphingolipids.
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Pertussis toxin produces differential inhibitory effects on basal, P2-purinergic, and chemotactic peptide-stimulated inositol phospholipid breakdown in HL-60 cells and HL-60 cell membranes.
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Pertussis toxin sensitive G-protein coupling of HDL receptor to phospholipase C in human platelets.
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Pertussis toxin-sensitive activation of phospholipase C by the C5a and fMet-Leu-Phe receptors.
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Pertussis toxin-sensitive and -insensitive mechanisms for diacylglycerol-protein kinase C signalling during insulin action in BC3H-1 myocytes.
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Pharmacological and molecular characterization of the mechanisms involved in prostaglandin E2-induced mouse paw edema.
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Pharmacological characterization of the receptor mediating the anorexigenic action of the octadecaneuropeptide: evidence for an endozepinergic tone regulating food intake.
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Phorbol ester and phospholipase C-induced growth hormone secretion from pituitary somatotroph adenoma cells in culture: effects of somatostatin, bromocriptine, and pertussis toxin.
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Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells.
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Phospholipase C activation and Ca2+ mobilization by cloned human somatostatin receptor subtypes 1-5, in transfected COS-7 cells.
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Phospholipase C activation by neurotensin and neuromedin N in Chinese hamster ovary cells expressing the rat neurotensin receptor.
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Phospholipase C activation by VIP1 and VIP2 receptors expressed in COS 7 cells involves a pertussis toxin-sensitive mechanism.
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Phospholipase C activity in NCB-20 cells is inhibited by protein kinase A-mediated phosphorylation of low molecular mass GTP-binding proteins.
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Phospholipase C activity is enhanced in skin fibroblasts obtained from patients with essential hypertension.
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Phospholipase C and phospholipase D are activated independently of each other in chemotactic peptide-stimulated human neutrophils.
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Phospholipase C in living cells: activation, inhibition, Ca2+ requirement, and regulation of M current.
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Phospholipase C isoforms in vascular smooth muscle and their regulation by G-proteins.
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Phospholipase C, protein kinase C, Ca(2+)/calmodulin-dependent protein kinase II, and tyrosine phosphorylation are involved in carbachol-induced phospholipase D activation in Chinese hamster ovary cells expressing muscarinic acetylcholine receptor of Caenorhabditis elegans.
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Phospholipase C-beta 1 is regulated by a pertussis toxin-insensitive G-protein.
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Phospholipase C-beta3 mediates the thrombin-induced Ca2+ response in glial cells.
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Phytosphingosine-1-phosphate stimulates chemotactic migration of L2071 mouse fibroblasts via pertussis toxin-sensitive G-proteins.
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Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates adenylyl cyclase and phospholipase C activity in rat cerebellar neuroblasts.
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Plasma membrane associated phospholipase C from human platelets: synergistic stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis by thrombin and guanosine 5'-O-(3-thiotriphosphate).
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Platelet-activating factor-induced phosphoinositide metabolism in differentiated U-937 cells in culture.
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Pleurocidin, a novel antimicrobial peptide, induces human mast cell activation through the FPRL1 receptor.
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Possible involvement of a GTP-binding protein in a late event during endogenous ganglioside-modulated cellular proliferation.
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Potentiating effects of pertussis toxin on leukotriene C4 induced formation of inositol phosphate and prostacyclin in human umbilical vein endothelial cells.
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Potentiation of Gi-mediated phospholipase C activation by retinoic acid in HL-60 cells. Possible role of G gamma 2.
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Potentiation of nicotinic currents by bradykinin in the paratracheal ganglia neurons of rats.
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Potentiation of Sulfonylurea Action by an EPAC-selective cAMP Analog in INS-1 cells: comparison of Tolbutamide and Gliclazide and a potential role for EPAC activation of a 2-APB-sensitive Ca2+ influx.
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Preactivation permits subsequent stimulation of phospholipase C by G(i)-coupled receptors.
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Presence of phospholipase C in coated vesicles from bovine brain. Dual regulatory effects of GTP-analogs.
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Progesterone triggers rapid transmembrane calcium influx and/or calcium mobilization from endoplasmic reticulum, via a pertussis-insensitive G-protein in granulosa cells in relation to luteinization process.
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Prostaglandin E2-induced arachidonic acid release and catecholamine secretion from cultured bovine adrenal chromaffin cells.
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Prostaglandin receptors in NIH 3T3 cells: coupling of one receptor to adenylate cyclase and of a second receptor to phospholipase C.
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Prostaglandins inhibit proliferation of the murine P815 mastocytoma by decreasing cytoplasmic free calcium levels [( Ca+2]i).
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Prostanoid receptor with a novel pharmacological profile in human erythroleukemia cells.
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Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling.
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Purinergic receptor-mediated morphological changes in microglia are transient and independent from inflammatory cytokine release.
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Ranakinin, a naturally occurring tachykinin, stimulates phospholipase C activity in the frog adrenal gland.
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Rapid membrane responses to dihydrotestosterone are sex dependent in growth plate chondrocytes.
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Receptor-mediated ADP-ribosylation of a phospholipase C-stimulating G protein.
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Reconstitution of chemokine-induced actin polymerization in undifferentiated human leukemia cells (HL-60) by heterologous expression of interleukin-8 receptors.
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Regulation of angiotensin II-induced G protein signaling by phosducin-like protein.
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Regulation of glucose carrier activity by AlCl3 and phospholipase C in fat-cells.
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Regulation of neutrophil NADPH oxidase activation in a cell-free system by guanine nucleotides and fluoride. Evidence for participation of a pertussis and cholera toxin-insensitive G protein.
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Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq.
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Regulation of thyrotropin-releasing hormone receptor binding and phospholipase C activation by a single GTP-binding protein.
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Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.
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Restoration of the transient outward potassium current by noradrenaline in chagasic canine epicardium.
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Rhythmic expression of adenylyl cyclase VI contributes to the differential regulation of serotonin N-acetyltransferase by bradykinin in rat pineal glands.
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Role of a guanine nucleotide regulatory protein in the activation of phospholipase C by different chemoattractants.
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Role of guanine nucleotide-binding protein and tyrosine kinase in platelet-activating factor activation of phospholipase C in A431 cells: proposal for dual mechanisms.
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Role of mitogen-activated protein kinase in prostaglandin f(2alpha) action in human granulosa-luteal cells.
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Role of pertussis toxin-sensitive G proteins in stimulus-dependent human eosinophil degranulation.
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Role of pertussis toxin-sensitive G-proteins in intracellular Ca2+ release and apoptosis induced by inhibiting cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels in HepG2 human hepatoblastoma cells.
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S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells.
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Secretion of the Bordetella pertussis adenylate cyclase from Escherichia coli containing the hemolysin operon.
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Selective activation by atrial natriuretic factor of phosphatidylcholine-specific phospholipase activities in purified heart muscle plasma membranes.
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Selective activation of phospholipase C by recombinant G-protein alpha- and beta gamma-subunits.
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Selective inhibition of beta(2)-adrenergic receptor-mediated cAMP generation by activation of the P2Y(2) receptor in mouse pineal gland tumor cells.
Whooping Cough
Selectivity and evolutionary divergence of metabotropic glutamate receptors for endogenous ligands and G proteins coupled to phospholipase C or TRP channels.
Whooping Cough
Serotonin as a major serum factor inducing the phospholipase C-mediated hydrolysis of phosphoinositides in normal rat kidney cells.
Whooping Cough
Serotonin stimulates DNA synthesis in fibroblasts acting through 5-HT1B receptors coupled to a Gi-protein.
Whooping Cough
Signal transduction for melatonin in human lymphocytes: involvement of a pertussis toxin-sensitive G protein.
Whooping Cough
Signal transduction mechanism involved in Clostridium perfringens alpha-toxin-induced superoxide anion generation in rabbit neutrophils.
Whooping Cough
Signal transduction mechanisms of Ca2+ mobilizing hormones: the case of gonadotropin-releasing hormone.
Whooping Cough
Signal transduction pathways and cellular intoxication with Clostridium difficile toxins.
Whooping Cough
Signal transduction pathways for activation of extracellular signal-regulated kinase by arachidonic acid in rat neutrophils.
Whooping Cough
Signal transduction pathways responsible for serotonin-mediated prostaglandin G/H synthase expression in rat mesangial cells.
Whooping Cough
Signal transduction via the B cell antigen receptor: involvement of a G protein and regulation of signaling.
Whooping Cough
Signaling and ligand binding by recombinant neuromedin U receptors: evidence for dual coupling to Galphaq/11 and Galphai and an irreversible ligand-receptor interaction.
Whooping Cough
Signaling cross-talk between cannabinoid and muscarinic systems actives Rho-kinase and increases the contractile responses of the bovine ciliary muscle.
Whooping Cough
Signalling components involved in the coupling of alpha 1-adrenoceptors to phospholipase D in neonatal rat cardiac myocytes.
Whooping Cough
Specific isoprenyl group linked to transducin gamma-subunit is a determinant of its unique signaling properties among G-proteins.
Whooping Cough
Sphingosine 1-phosphate protects human umbilical vein endothelial cells from serum-deprived apoptosis by nitric oxide production.
Whooping Cough
Sphingosine 1-phosphate stimulates hydrogen peroxide generation through activation of phospholipase C-Ca2+ system in FRTL-5 thyroid cells: possible involvement of guanosine triphosphate-binding proteins in the lipid signaling.
Whooping Cough
Sphingosine 1-phosphate stimulates tyrosine phosphorylation of focal adhesion kinase and chemotactic motility of endothelial cells via the G(i) protein-linked phospholipase C pathway.
Whooping Cough
Sphingosylphosphorylcholine induces proliferation of human adipose tissue-derived mesenchymal stem cells via activation of JNK.
Whooping Cough
Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entry.
Whooping Cough
Spontaneous phase variation in Bordetella pertussis is a multistep non-random process.
Whooping Cough
Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
Whooping Cough
Stimulation of adenosine A1 receptors and bradykinin receptors, which act via different G proteins, synergistically raises inositol 1,4,5-trisphosphate and intracellular free calcium in DDT1 MF-2 smooth muscle cells.
Whooping Cough
Stimulation of adenosine receptor enhances alpha 1-adrenergic receptor-mediated activation of phospholipase C and Ca2+ mobilization in a pertussis toxin-sensitive manner in FRTL-5 thyroid cells.
Whooping Cough
Stimulation of Bordetella pertussis adenylate cyclase toxin intoxication by its hemolysin domain.
Whooping Cough
Stimulation of histamine H2- (and H1)-receptors activates Ca2+ influx in all-trans-retinoic acid-differentiated HL-60 cells independently of phospholipase C or adenylyl cyclase.
Whooping Cough
Stimulation of peripheral nociceptor endings by low dose morphine and its signaling mechanism.
Whooping Cough
Stimulation of phospholipase C-mediated hydrolysis of phosphoinositides by adenosine 5'-triphosphate via P2-purinoceptors in cultured rat aortic vascular smooth muscle cells.
Whooping Cough
Stimulation of the T-cell receptors CD3 and CD2 with OKT3 and OKT11 antibodies activates a common pertussis toxin-insensitive G-protein.
Whooping Cough
Stimulatory and inhibitory actions of lysophosphatidylcholine, depending on its fatty acid residue, on the phospholipase C/Ca2+ system in HL-60 leukaemia cells.
Whooping Cough
Stimulus-response coupling in monocytes infected with Leishmania. Attenuation of calcium transients is related to defective agonist-induced accumulation of inositol phosphates.
Whooping Cough
Strong and persistent activation of inositol lipid breakdown induces early mitogenic events but not Go to S phase progression in hamster fibroblasts. Comparison of thrombin and carbachol action in cells expressing M1 muscarinic acetylcholine receptors.
Whooping Cough
Studies of the cellular mechanisms underlying the vasorelaxant effects of rutaecarpine, a bioactive component extracted from an herbal drug.
Whooping Cough
Studies on opsonized zymozan, FMLP, carbachol, PMA and A23187 stimulated respiratory burst of human PMNLs.
Whooping Cough
Surface proteins of Bordetella pertussis: comparison of virulent and avirulent strains and effects of phenotypic modulation.
Whooping Cough
Synergistic activation of phospholipases Cgamma and Cbeta: A novel mechanism for PI3K-independent enhancement of FcepsilonRI-induced mast cell mediator release.
Whooping Cough
Tannin stimulates arachidonic acid release from bovine tracheal epithelial cells.
Whooping Cough
Targeted mutations that ablate either the adenylate cyclase or hemolysin function of the bifunctional cyaA toxin of Bordetella pertussis abolish virulence.
Whooping Cough
Testosterone modulates K(+)ATP channels in sertoli cell membrane via the PLC-PIP2 pathway.
Whooping Cough
Testosterone rapidly increases Ca(2+)-activated K(+) currents causing hyperpolarization in human coronary artery endothelial cells.
Whooping Cough
Testosterone signaling through internalizable surface receptors in androgen receptor-free macrophages.
Whooping Cough
TG1019/OXE, a Galpha(i/o)-protein-coupled receptor, mediates 5-oxo-eicosatetraenoic acid-induced chemotaxis.
Whooping Cough
The alpha 1C-adrenergic receptor: characterization of signal transduction pathways and mammalian tissue heterogeneity.
Whooping Cough
The beta-amyloid precursor protein controls a store-operated Ca2+ entry in cortical neurons.
Whooping Cough
The C-terminal domain is essential for protective activity of the Bordetella pertussis adenylate cyclase-hemolysin.
Whooping Cough
The Ca2+-sensing receptor activates cytosolic phospholipase A2 via a Gqalpha -dependent ERK-independent pathway.
Whooping Cough
The calcium-sensing receptor regulates calcium absorption in MDCK cells by inhibition of PMCA.
Whooping Cough
The effect of pertussis toxin on alpha 1-adrenoceptor-mediated vasoconstriction by the full agonist, cirazoline, and the partial agonist, (-)-dobutamine, in pithed rats.
Whooping Cough
The endozepine ODN stimulates polyphosphoinositide metabolism in rat astrocytes.
Whooping Cough
The epidermal growth factor receptor is coupled to a pertussis toxin-sensitive guanine nucleotide regulatory protein in rat hepatocytes.
Whooping Cough
The G protein beta gamma subunit transduces the muscarinic receptor signal for Ca2+ release in Xenopus oocytes.
Whooping Cough
The human V3 pituitary vasopressin receptor: ligand binding profile and density-dependent signaling pathways.
Whooping Cough
The inositol phosphate response to thrombin in rat right atria differs from the response to noradrenaline.
Whooping Cough
The M3 muscarinic acetylcholine receptor expressed in HEK-293 cells signals to phospholipase D via G12 but not Gq-type G proteins: regulators of G proteins as tools to dissect pertussis toxin-resistant G proteins in receptor-effector coupling.
Whooping Cough
The mechanism of MAP kinase activation under acidic condition in feline esophageal smooth muscle cells.
Whooping Cough
The metabotropic glutamate receptor MGLU7, activates PLC, translocates MUNC-13-1 protein and potentiates glutamate release at cerebrocortical nerve terminals.
Whooping Cough
The neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) modulate several biochemical pathways in human leukemic myeloid cells.
Whooping Cough
The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues.
Whooping Cough
The rat cytomegalovirus R33-encoded G protein-coupled receptor signals in a constitutive fashion.
Whooping Cough
Thrombin signalling in U937 human monocytic cells is coupled to inositol phosphate formation but not to thromboxane B2 synthesis nor to inhibition of adenylate cyclase: distinct differences in thrombin signalling between U937 cells and platelets.
Whooping Cough
Thrombin-mediated phosphoinositide hydrolysis in Chinese hamster ovary cells overexpressing phospholipase C-delta 1.
Whooping Cough
Thromboxane A2 activates phospholipase C in astrocytoma cells via pertussis toxin-insensitive G-protein.
Whooping Cough
Thromboxane A2 analogue U 46619 enhances tumour cell proliferation in HeLa cells via specific receptors which are apparently distinct from TXA2 receptors on human platelets.
Whooping Cough
Thyrotropin-releasing hormone and gonadotropin-releasing hormone receptors activate phospholipase C by coupling to the guanosine triphosphate-binding proteins Gq and G11.
Whooping Cough
Transcellular signaling and pharmacological modulation of thrombin-induced production of plasminogen activator inhibitor-1 in vascular smooth muscle cells.
Whooping Cough
Transduction of intracellular calcium signals through G protein-mediated activation of phospholipase C by recombinant sphingosine 1-phosphate receptors.
Whooping Cough
Transfected human somatostatin receptor type 2, SSTR2, not only inhibits adenylate cyclase but also stimulates phospholipase C and Ca2+ mobilization.
Whooping Cough
Transforming growth factor-beta1 regulation of resting zone chondrocytes is mediated by two separate but interacting pathways.
Whooping Cough
Trypanosoma cruzi: infection of cultured human endothelial cells alters inositol phosphate synthesis.
Whooping Cough
Two basic amino acids in the second inner loop of the interleukin-8 receptor are essential for Galpha16 coupling.
Whooping Cough
Two distinct Gi-proteins mediate formyl peptide receptor signal transduction in human leukemia (HL-60) cells.
Whooping Cough
Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin.
Whooping Cough
Two types of G proteins involved in regulation of phosphoinositide turnover in pulmonary endothelial cells.
Whooping Cough
Tyrosine kinase-activating growth factors potentiate thrombin- and AIF4- -induced phosphoinositide breakdown in hamster fibroblasts. Evidence for positive cross-talk between the two mitogenic signaling pathways.
Whooping Cough
Tyrosine phosphorylation is involved in reorganization of the actin cytoskeleton in response to serum or LPA stimulation.
Whooping Cough
U-73122, a phospholipase C antagonist, inhibits effects of endothelin-1 and parathyroid hormone on signal transduction in UMR-106 osteoblastic cells.
Whooping Cough
Unsaturated fatty acids mobilize intracellular calcium independent of IP3 generation and VIA insertion at the plasma membrane.
Whooping Cough
Urokinase activates calcium-dependent potassium channels in U937 cells via calcium release from intracellular stores.
Whooping Cough
Use of pertussis toxin to investigate the mechanism of action of prostaglandin F2 alpha on the corpus luteum in sheep.
Whooping Cough
Vasopressin regulates adrenal functions by acting through different vasopressin receptor subtypes.
Whooping Cough
[Effect of interleukin-2 on intracellular calcium transients in rat ventricular myocytes]
Whooping Cough
[Immunobiologic activity of Bordetella pertussis strains defective in various virulence factors]
Whooping Cough
[Physiopathological role of low affinity IgE receptor (CD23) in hematopoietic cells]
Whooping Cough
[Regulation mechanisms of receptors mediated activation of phospholipase c and inositol-1,4,5-triphosphate sensitive Ca2+ release and Ca2+ uptake in exocrine glandular cells]
Whooping Cough
[The discovery of neuromedin U and its pivotal role in the central regulation of energy homeostasis].
Wilms Tumor
Auxiliary genetic analysis in a Chinese adolescent NPH family by single nucleotide polymorphism screening.
Wilms Tumor
Genetic mutational testing of Chinese children with familial hematuria with biopsy?proven FSGS.
Wound Infection
NMR structure of the Bacillus cereus hemolysin II C-terminal domain reveals a novel fold.
Wound Infection
Production of extracellular virulence factors by Pseudomonas aeruginosa isolates obtained from tracheal, urinary tract, and wound infections.
Wound Infection
[In vitro virulence of wound infecting staphylococcal isolates from severely burned patients]
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
1268
-
substrate: phosphatidylinositol-4,5-bisphosphate, PLC d1 with poly-His-tail, no significant change of activity after cleavage of poly-His-tail, expression at 16°C for 72 h
404
-
substrate: phosphatidylinositol-4,5-bisphosphate, PLC d3 with poly-His-tail, no significant change of activity after cleavage of poly-His-tail, expression at 16°C for 72 h
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
segment-specific expression pattern of NPP6 in nephrons shown
brenda
-
different cell lines of epithelial ovarian cancer cells (EOC) compared with nontumoral (normal or immortalized) counterparts (EONT)
brenda
-
substantial intracellular amounts of isoform PC-PLC in all lymphoid subsets
brenda
-
monocyte-derived macrophage, enzyme is activated by HIV-1 R5 gp120 interaction with CCR5 and is required for NF-kB-mediated chemokine CCL2 production triggered by R5 gp120
brenda
additional information
-
suppression of isoform PC-PLC inhibits apoptosis in young cells, but not in senescent cells, and depresses reactive oxygen species levels in both young and senescent cells
brenda
-
high level of enzyme expression on the outer membrane surface. Identification of two subsets of cells, CD56dimPC-PLCbright and CD56brightPC-PLClow/-, corresponding to distinct subsets with cytolytic and immunoregulatory function. Enzyme expression level on the membrane closely correlates with that of the CD16 receptor
brenda
additional information
no expression of NPP6 detectable in heart, stomach, placenta, intestine, and leukocyte
brenda
additional information
-
no expression of NPP6 detectable in heart, stomach, placenta, intestine, and leukocyte
brenda
additional information
-
no detection of enzyme expression on CD4+ and CD8+ T lymphocytes
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
after activation by IL-2, cytoplasmic enzyme translocates to outer cell surface, mechanism
brenda
-
colocalization of PC-PLC with the ER, mainly within the Golgi apparatus in NK-resting cells. A much more extended colocalization of PC-PLC with the ER marker is observed in NK-activated cells, in which the enzyme is not exclusively confined to the Golgi region
brenda
-
colocalization of PC-PLC with the ER, mainly within the Golgi apparatus in NK-resting cells. A much more extended colocalization of PC-PLC with the ER marker is observed in NK-activated cells, in which the enzyme is not exclusively confined to the Golgi region
brenda
additional information
-
epifluorescence, CLSM, and flow cytometry experiments demonstrate that PC-PLC is expressed both in cytoplasmic compartments and on the outer cell surface of either resting or activated NK cells
-
brenda
-
after activation by IL-2, cytoplasmic enzyme translocates to outer cell surface, mechanism
brenda
-
IL-2-dependent distribution between cytoplasm and ectoplasmic membrane surface in human NK cells
brenda
-
high level of enzyme expression on the outer membrane surface of natural killer cells. Enzyme expression level on the membrane closely correlates with that of the CD16 receptor
brenda
-
ectoplasmic, IL-2-dependent distribution between cytoplasm and ectoplasmic membrane surface in human NK cells
brenda
-
association of isoform PC-PLC with CD16 receptor, partial accumulation of both in lipid rafts. Antibody-mediated CD16 cross-linking results in an about twofold increase in PC-PLC enzyme activity within 10 min
brenda
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
-
inhibition of the enzyme abrogates the Yersinia pseudotuberculosis-induced repression of caspase 3 activity
metabolism
-
protein kinase C and phosphatidylcholine-specific phospholipase C, but not tyrosine kinases or phosphatidylinositol-specific phospholipase C are key players in this dual polymorphonuclear leukocyte response to bacterial infection, e.g. by Yersinia pseudotuberculosis, Escherichia coli, or Staphylococcus aureus, and by pro-inflammatory cytokine production including interleukin-8 and tumor necrosis factor-alpha
physiological function
-
the enzyme signaling is required for polymorphonuclear leukocyte survival after bacterial infection and Toll-like receptor-mediated induction of interleukin-8 and TNFalpha gene expression. The enzyme activity is involved in bacteria-mediated suppression of caspase 3 activity
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
40000
-
two PC-PLC isoforms, 40 and 66 kDa. The same PC-PLC isoforms are also detected in some leukemia cells, such as K562 and DAUDI. In U937 cells only the 40 kDa isoform is detected
66000
66000
-
two PC-PLC isoforms, 40 and 66 kDa. The same PC-PLC isoforms are also detected in some leukemia cells, such as K562 and DAUDI
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
physical association of isoform PC-PLC with CD16 receptor, partial accumulation of both in lipid rafts
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POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phosphoprotein
-
serine-phosphorylation of enzyme after treatment with IL-2, phosphorylation is abolished after MAPK inhibition
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hNPP6-ex
truncated form of hNPP6, cDNA for the extracellular domain of hNPP6, amino acids 1-421
additional information
-
separate expression of amino- and C-terminal fragments of enzyme, requirements for reconstitution of enzyme activity and activation by Gbetagamma
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
24
-
for 60 min, recombinant PLC delta 1 and delta 3 with poly-His-tail, no loss of activity
37
-
for 30 min, recombinant PLC delta 1 and delta 3 with poly-His-tail, no loss of activity
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, buffer B, purified recombinant PLC d1 and d3 with poly-His-tail, activity stable over 2 years, more than 15 freeze/thaw cycles between -20°C and 4°C reduce activity by 10-20%
-
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
mono Q ion exchange chromatography column and eluted with a linear gradient of NaCl (0-2 M) using the deltaKTA system
recombinant PLC d1 and D3 with poly-His-tail at the amino terminus, metal ion affinity chromatography
-
recombinant PLC d1 and D3 without poly-His-tail at the amino terminus, cation exchange HPLC and phosphocellulose chromatography
-
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
drug development
-
elucidation of the mechanisms responsible for aberrant phosphatidylcholine metabolism in cancer cells may allow identification of novel biomarkers of tumor progression and design of new targeted anticancer therapies
medicine
medicine
-
chemokine CCL2, i.e. MCP-1, enhances HIV-1 replication. Enzyme isoform PC-PLC is activated by HIV-1 R5 gp120 interaction with CCR5 and is required for NF-kB-mediated CCL2 production triggered by R5 gp120 in monocyte-derived macrophages
medicine
-
tumor suppressor PTEN is involved in both phospholipase C and phospholipase D activation pathways. Pathogenesis of Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome has further aspects beyond activating the PI3K pathway
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Seishima, M.; Iwasaki-Bessho, Y.; Itoh, Y.; Nozawa, Y.; Amagai, M.; Kitajima, Y.
Phosphatidylcholine-specific phospholipase C, but not phospholipase D, is involved in pemphigus IgG-induced signal transduction
Arch. Dermatol. Res.
291
606-613
1999
Homo sapiens
brenda
Pawelczyk, T.; Matecki, A.
Expression, purification and kinetic properties of human recombinant phospholipase C delta 3
Acta Biochim. Pol.
44
221-229
1997
Homo sapiens
brenda
Ghosh, S.; Pawalczyk, T.; Lowenstein, J.M.
Phospholipase C isoforms d1 and d3 from human fibroblasts
Protein Expr. Purif.
9
262-278
1997
Homo sapiens, Rattus norvegicus
brenda
Meij, J.T.A.; Ross, E.T.
Purification and characterization of phospholipase C-1 mutants expressed in E.coli
Biochem. Biophys. Res. Commun.
225
705-711
1996
Homo sapiens
brenda
Vitale, M.; Matteucci, A.; Manzoli, L.; Rodella, L.; Mariani, A.R.; Zauli, G.; Falconi, M.; Billi, A.M.; Martelli, A.M.; Gilmour, R.S.; Cocco, L.
Interleukin-2 activates nuclear phospholipase-Cb by mitogen-activated protein kinase-dependent phosphorylation in human natural killer cells
FASEB J.
15
1789-1791
2001
Homo sapiens
brenda
Zhang, W.; Neer, E.J.
Reassembly of phospholipase C-b2 from separated domains: analysis of basal and G protein-stimulated activities
J. Biol. Chem.
276
2503-2508
2001
Homo sapiens
brenda
Ramoni, C.; Spadaro, F.; Menegon, M.; Podo, F.
Cellular localization and functional role of phosphatidylcholine-specific phospholipase C in NK cells
J. Immunol.
167
2642-2650
2001
Homo sapiens
brenda
Sakagami, H.; Aoki, J.; Natori, Y.; Nishikawa, K.; Kakehi, Y.; Arai, H.
Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family
J. Biol. Chem.
280
23084-23093
2005
Homo sapiens (Q6UWR7), Homo sapiens, Mus musculus (Q8BGN3)
brenda
Fantuzzi, L.; Spadaro, F.; Purificato, C.; Cecchetti, S.; Podo, F.; Belardelli, F.; Gessani, S.; Ramoni, C.
Phosphatidylcholine-specific phospholipase C activation is required for CCR5-dependent, NF-kB-driven CCL2 secretion elicited in response to HIV-1 gp120 in human primary macrophages
Blood
111
3355-3363
2008
Homo sapiens
brenda
Liu, X.; Zhao, Q.; Araki, S.; Zhang, S.; Miao, J.
Contrasting effects of phosphatidylinositol- and phosphatidylcholine-specific phospholipase C on apoptosis in cultured endothelial cells
Endothelium
13
205-211
2006
Homo sapiens
brenda
Spadaro, F.; Cecchetti, S.; Sanchez, M.; Ausiello, C.M.; Podo, F.; Ramoni, C.
Expression and role of phosphatidylcholine-specific phospholipase C in human NK and T lymphocyte subsets
Eur. J. Immunol.
36
3277-3287
2006
Homo sapiens
brenda
Cecchetti, S.; Spadaro, F.; Lugini, L.; Podo, F.; Ramoni, C.
Functional role of phosphatidylcholine-specific phospholipase C in regulating CD16 membrane expression in natural killer cells
Eur. J. Immunol.
37
2912-2922
2007
Homo sapiens
brenda
Cheng, Y.; Zhao, Q.; Liu, X.; Araki, S.; Zhang, S.; Miao, J.
Phosphatidylcholine-specific phospholipase C, p53 and ROS in the association of apoptosis and senescence in vascular endothelial cells
FEBS Lett.
580
4911-4915
2006
Homo sapiens
brenda
Alvarez-Breckenridge, C.A.; Waite, K.A.; Eng, C.
PTEN regulates phospholipase D and phospholipase C
Hum. Mol. Genet.
16
1157-1163
2007
Homo sapiens
brenda
Spadaro, F.; Ramoni, C.; Mezzanzanica, D.; Miotti, S.; Alberti, P.; Cecchetti, S.; Iorio, E.; Dolo, V.; Canevari, S.; Podo, F.
Phosphatidylcholine-specific phospholipase C activation in epithelial ovarian cancer cells
Cancer Res.
68
6541-6549
2008
Homo sapiens
brenda
Erttmann, S.F.; Gekara, N.O.; Faellman, M.
Bacteria induce prolonged PMN survival via a phosphatidylcholine-specific phospholipase C- and protein kinase C-dependent mechanism
PLoS ONE
9
e87859
2014
Homo sapiens
brenda
Udawela, M.; Scarr, E.; Boer, S.; Um, J.Y.; Hannan, A.J.; McOmish, C.; Felder, C.C.; Thomas, E.A.; Dean, B.
Isoform specific differences in phospholipase C beta 1 expression in the prefrontal cortex in schizophrenia and suicide
NPJ Schizophr.
3
19
2017
Homo sapiens
brenda
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