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Information on EC 3.1.4.16 - 2',3'-cyclic-nucleotide 2'-phosphodiesterase and Organism(s) Yersinia enterocolitica and UniProt Accession P53052

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IUBMB Comments
Also hydrolyses 3'-nucleoside monophosphates and bis-4-nitrophenyl phosphate, but not 3'-deoxynucleotides. Similar reactions are carried out by EC 4.6.1.24 (ribonuclease T1) and EC 4.6.1.18 (pancreatic ribonuclease).
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This record set is specific for:
Yersinia enterocolitica
UNIPROT: P53052
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The taxonomic range for the selected organisms is: Yersinia enterocolitica
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
rv0805, 2',3'-cyclic nucleotide phosphohydrolase, 2',3'-cyclic phosphodiesterase, 2',3'-cyclic nucleotide 2'-phosphodiesterase, 2',3'-camp phosphodiesterase, yfce-c74h, 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2',3'-cyclic nucleotidase, 2':3'-cyclic phosphodiesterase, cyclic 2',3'-nucleotide phosphodiesterase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2',3'-cyclic AMP 2'-phosphohydrolase
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2',3'-cyclic AMP phosphodiesterase
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2',3'-cyclic nucleoside monophosphate phosphodiesterase
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2',3'-cyclic nucleotidase
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2',3'-cyclic nucleotide 2'-phosphodiesterase
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2',3'-cyclic nucleotide phosphohydrolase
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2',3'-cyclic phosphodiesterase
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2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase
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2':3'-cyclic phosphodiesterase
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cyclic 2',3'-nucleotide phosphodiesterase
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cyclic phosphodiesterase:3'-nucleotidase
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cyclic-2',3'-nucleotide 2'-phosphohydrolase
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phosphodiesterase, cyclic 2',3'-nucleotide 2'-
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ribonucleoside 2',3'-cyclic phosphate diesterase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase
Also hydrolyses 3'-nucleoside monophosphates and bis-4-nitrophenyl phosphate, but not 3'-deoxynucleotides. Similar reactions are carried out by EC 4.6.1.24 (ribonuclease T1) and EC 4.6.1.18 (pancreatic ribonuclease).
CAS REGISTRY NUMBER
COMMENTARY hide
9037-18-7
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
cyclic 2',3'-AMP + H2O
3'-AMP
show the reaction diagram
-
-
?
cyclic 2',3'-CMP + H2O
3'-CMP
show the reaction diagram
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-
?
cyclic 2',3'-GMP + H2O
3'-GMP
show the reaction diagram
-
-
?
cyclic 2',3'-UMP + H2O
3'-UMP
show the reaction diagram
-
-
?
di(p-nitrophenyl) phosphate + H2O
p-nitrophenol + p-nitrophenyl phosphate
show the reaction diagram
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-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 3'-phosphate
show the reaction diagram
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?
p-nitrophenyl phosphorylcholine + H2O
?
show the reaction diagram
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?
additional information
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
O:8 strains WA-C and WA-314
SwissProt
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
enzyme is exported to the periplasmic space
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Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CPDB_YEREN
652
0
71492
Swiss-Prot
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
68000
x * 71958, CpdB including the N-terminal signal sequence, calculated from the amino acid sequence, x * 68000, mature peptide without the signal sequence, SDS-PAGE
71958
x * 71958, CpdB including the N-terminal signal sequence, calculated from the amino acid sequence, x * 68000, mature peptide without the signal sequence, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 71958, CpdB including the N-terminal signal sequence, calculated from the amino acid sequence, x * 68000, mature peptide without the signal sequence, SDS-PAGE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
proteolytic modification
contains an N-terminal signal sequence of 25 amino acids
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cpdB gene, overexpression in Escherichia coli HB101, characterization of the gene
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Trulzsch, K.; Roggenkamp, A.; Pelludat, C.; Rakin, A.; Jacobi, C.A.; Heesemann, J.
Cloning and characterization of the gene encoding periplasmic 2',3'-cyclic phosphodiesterase of Yersinia enterocolitica O:8
Microbiology
147
203-213
2001
Yersinia enterocolitica (P53052), Yersinia enterocolitica
Manually annotated by BRENDA team