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Information on EC 3.1.4.11 - phosphoinositide phospholipase C and Organism(s) Mus musculus and UniProt Accession Q8K4S1

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.11 phosphoinositide phospholipase C
IUBMB Comments
These enzymes form some of the cyclic phosphate Ins(cyclic1,2)P(4,5)P2 as well as Ins(1,4,5)P3. They show activity towards phosphatidylinositol, i.e., the activity of EC 4.6.1.13, phosphatidylinositol diacylglycerol-lyase, in vitro at high [Ca2+]. Four beta-isoforms regulated by G-proteins, two gamma-forms regulated by tyrosine kinases, four delta-forms regulated at least in part by calcium and an epsilon-form, probably regulated by the oncogene ras, have been found.
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Mus musculus
UNIPROT: Q8K4S1
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
pi-plc, phosphatidylinositol-specific phospholipase c, plc-gamma, plc-gamma1, plcgamma1, plc-beta, plcgamma, phosphoinositide-specific phospholipase c, plcgamma2, phospholipase c-gamma1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospholipase Cepsilon
-
1-phosphatidyl-D-myo-inositol 4,5-bisphosphate inositoltrisphosphohydrolase
-
-
-
-
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
-
-
-
-
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
-
No receptor potential A protein
-
-
-
-
phosphatidylinositol 4,5-bisphosphate phosphodiesterase
-
-
-
-
phosphatidylinositol phosphodiesterase
-
-
phosphatidylinositol specific phospholipase C
-
-
phosphatidylinositol-4,5-bisphosphate phosphodiesterase
-
-
-
-
phosphatidylinositol-4,5-bisphosphate phospholipase C
-
-
-
-
phosphodiesterase, triphosphoinositide
-
-
-
-
phosphoinositidase C
-
-
-
-
phosphoinositide phospholipase C
-
phosphoinositide-specific phospholipase C
phosphoinositide-specific phospholipase C beta1
-
phosphoinositide-specific phospholipase C-zeta
-
-
phosphoinositide-specific phospholipase-Cgamma
-
-
phospholipase C
-
-
-
-
phospholipase C beta1
-
phospholipase C epsilon
-
-
phospholipase C zeta
-
-
phospholipase C-beta-1
-
phospholipase C-delta-1
-
phospholipase C-eta1a
-
phospholipase C-eta1c
-
phospholipase C-gamma2
phospholipase Cgamma1
-
-
phospholipase Cgamma2
phosphotidylinositol 4,5-bisphosphate-specific phospholipase C
-
-
-
-
PI-PLC
PI-PLC beta 1
-
PI-PLC-ß1
-
-
PI-specific phospholipase C
-
PIC
-
-
-
-
PIP2 PDE
-
-
-
-
PIP2 phosphodiesterase
-
-
-
-
PIPLC
-
-
-
-
PLC zeta
-
-
PLC-148
-
-
-
-
PLC-154
PLC-85
-
-
-
-
PLC-beta-1
-
PLC-delta-1
-
PLC-delta1
-
-
PLC-eta1
-
-
PLC-eta2
-
-
PLC-gamma2
-
PLC-zeta
PLCbeta1
PLCbeta2
-
isoform
PLCbeta3
-
isoform
PLCbeta4
-
isoform
PLCdelta1
PLCdelta3
-
isoform
PLCdelta4
-
isoform
PLCepsilon
-
isoform
PLCeta1
-
isoform
PLCeta2
PLCgamma
-
-
PLCgamma1
PLCgamma2
polyphosphoinositide phospholipase C
-
-
-
-
PtdIns phosphodiesterase
-
-
PtdIns(4,5)P2-directed phospholipase C
-
-
-
-
triphosphoinositide phosphodiesterase
-
-
-
-
additional information
-
ten mammalian isoenzymes, grouped into three families: PLCbeta, PLCgamma and PLCdelta
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
These enzymes form some of the cyclic phosphate Ins(cyclic1,2)P(4,5)P2 as well as Ins(1,4,5)P3. They show activity towards phosphatidylinositol, i.e., the activity of EC 4.6.1.13, phosphatidylinositol diacylglycerol-lyase, in vitro at high [Ca2+]. Four beta-isoforms regulated by G-proteins, two gamma-forms regulated by tyrosine kinases, four delta-forms regulated at least in part by calcium and an epsilon-form, probably regulated by the oncogene ras, have been found.
CAS REGISTRY NUMBER
COMMENTARY hide
37213-51-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-triphosphate + diacylglycerol
show the reaction diagram
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
show the reaction diagram
phosphatidylinositol + H2O
?
show the reaction diagram
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-triphosphate + diacylglycerol
show the reaction diagram
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3beta,27-dihydroxyurs-12-en-28-oic acid
-
-
3beta,7'-diacetoxy-27- 4-(E)-coumaroyloxyurs-12-en-28-oic acid
-
-
3beta-4-(E)-coumaroyloxyurs-12-en-28-oic acid
-
-
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
-
-
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
-
-
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
-
-
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
-
-
3beta-hydroxy-27-4-(E)-2'-dihydrocoumaroyloxyurs-12-en-28-oic acid
-
-
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
-
-
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
-
-
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic methyl ester
-
-
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
-
-
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
-
-
3beta-hydroxyurs-12-en-28-oic 4-(E)-coumaroyl ester
-
-
4-(E)-coumaric acid
-
-
adriamycin
-
-
amentoflavone
-
-
U-73122
U73122
-
-
additional information
-
not inhibited by 1-[6-[((17beta)-3-methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-2,5-pyrrolidinedione (i.e. U-73343)
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
arachidonic acid
-
enhances hyrolysis of phosphatidylinositol 4,5-diphosphate, membrane bound enzyme and cytosolic enzyme
Ca2+
-
requirement
diacylglycerol
-
enhances hyrolysis of phosphatidylinositol 4,5-diphosphate, membrane bound enzyme and cytosolic enzyme
insulin-like growth factor 1
-
stimulates nuclear PLCbeta1, through translocation of MAP kinase to the nucleus
-
MAP kinase
-
phosphorylates and activates nuclear PLCbeta1
-
phosphatidic acid
-
enhances hyrolysis of phosphatidylinositol 4,5-diphosphate, membrane bound enzyme and cytosolic enzyme
phosphatidylcholine
-
enhances hyrolysis of phosphatidylinositol 4,5-diphosphate, membrane bound enzyme
phosphatidylethanolamine
-
enhances hyrolysis of phosphatidylinositol 4,5-diphosphate, membrane bound enzyme and cytosolic enzyme
phosphatidylserine
-
enhances hyrolysis of phosphatidylinositol 4,5-diphosphate, membrane bound enzyme
additional information
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0182
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
Mus musculus
-
in P388 cells, pH 7.0, 37°C
0.0229
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
Mus musculus
-
in P388 cells, pH 7.0, 37°C
0.0175
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
Mus musculus
-
in P388 cells, pH 7.0, 37°C
0.0229
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
Mus musculus
-
in P388 cells, pH 7.0, 37°C
0.0186
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
Mus musculus
-
in P388 cells, pH 7.0, 37°C
0.0226
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
Mus musculus
-
in P388 cells, pH 7.0, 37°C
0.0174
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
Mus musculus
-
in P388 cells, pH 7.0, 37°C
0.0245
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
Mus musculus
-
in P388 cells, pH 7.0, 37°C
additional information
additional information
Mus musculus
-
IC50 value is less than 0.1 microM for adriamycin in in P388 cells, pH 7.0, 37°C
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.114
-
membrane-bound enzyme
0.235
-
cytosolic enzyme
additional information
-
PLC beta isoenzymes, activities in membrane deprived and intact nuclei
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.5
-
two optima 5.5 and 7.4
6
-
hydrolysis of phosphatidylinositol, membrane bound enzyme and cytosolic enzyme
6.7
assay at
7.4
-
two optima 5.5 and 7.4
7.5
-
hyrolysis of phosphatidylinositol 4,5-diphosphate, membrane bound enzyme and cytosolic enzyme
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SWissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
mesenteric, pulmonary and middle cerebral arteries
Manually annotated by BRENDA team
-
mechanosensitive activation of K+ channel via phospholipase C-induced depletion of phosphatidylinositol 4,5-bisphosphate
Manually annotated by BRENDA team
-
high PLC-beta3 expression in very early embryos
Manually annotated by BRENDA team
-
PLC-eta1
Manually annotated by BRENDA team
-
upper head, PLC-eta1
Manually annotated by BRENDA team
-
PLC-eta1
Manually annotated by BRENDA team
-
PLC-eta1
Manually annotated by BRENDA team
-
PLCgamma2 is the predominant isoform
Manually annotated by BRENDA team
PLCeta2 is restricted to brain. PLCeta2 gradually increases during brain development. PLCeta2 is not detected in embryos. At 1 week after birth PLCeta2 is barely detected and expression is first observed at weeks after birth
Manually annotated by BRENDA team
-
PLC-beta4
Manually annotated by BRENDA team
-
the gamma1 isoenzyme is restricted to the sperm head
Manually annotated by BRENDA team
sperm-specific PLCzeta
Manually annotated by BRENDA team
additional information
-
PLC-beta2 is highly expressed in cells of the immune system
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
PLCbeta1 is first exclusively localized to the nucleus and then migrates to the cytoplasm when the oocyte is fully grown. During oocyte maturation PLCbeta1 is active in the cytoplasm before it migrates and becomes active in the nucleus just prior to germinal vesicle breakdown
Manually annotated by BRENDA team
-
the basic cluster of phospholipase C-zeta could not only anchor the protein to the membrane, but also enhance the local concentration of phosphatidylinositol 4,5-bisphosphate adjacent to the catalytic domain
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
PLC isozymes are involved in several diseases, detailed overview
physiological function
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PLCE1_MOUSE
2282
0
255047
Swiss-Prot
other Location (Reliability: 3)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
115000
x * 115000, calculated from sequence
68000 - 70000
-
membrane-bound enzyme, in presence of sodium cholate, gel filtration
71000 - 72000
-
cytosolic enzyme, in presence of sodium deoxycholate, gel filtration
78000
x * 78000, recombinant His-tagged PLCzeta, SDS-PAGE
90000
x * 90000, recombinant His-tagged PLCdelta1, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
enzyme PLC-delta1 prepared by a baculovirus expression system
enzyme prepared by a baculovirus expression system
partial
-
preparation of nuclei, method development
recombinant PLCdelta1
recombinant PLCzeta
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
microinjection of recombinant PLCzeta protein into mouse eggs induces serial Ca2+ spikes quite similar to that produced by the injection of sperm extract, probably because of repetitive Ca2+ release from the endoplasmic reticulum caused by continuously produced inositol 1,4,5-trisphosphate
PLCdelta1, expression in Sf9 cells
PLCzeta, expression in Sf9 cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wang, P.; Toyoshima, S.; Osawa, T.
Partial purification and characterization of membrane-bound and cytosolic phosphatidylinositol-specific phospholipases C from murine thymocytes
J. Biochem.
100
1015-1022
1986
Mus musculus
Manually annotated by BRENDA team
Tomes, C.N.; McMaster, C.R.; Saling, P.M.
Activation of mouse sperm phosphatidylinositol-4,5-bisphosphate-phospholipase C by zona pellucida is modulated by tyrosine phosphorylation
Mol. Reprod. Dev.
43
196-204
1996
Mus musculus
Manually annotated by BRENDA team
Shute, J.K.; Smith, M.E.
Phosphatidylinositol phosphodiesterase in isolated plasma membranes of rodent skeletal muscle
Biochem. Soc. Trans.
13
193-194
1985
Mus musculus, Mus musculus C57BL, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
-
Manually annotated by BRENDA team
Ochocka, A.M.; Pawelczyk, T.
Isozymes delta of phosphoinositide-specific phospholipase C and their role in signal transduction in the cell
Acta Biochim. Pol.
50
1097-1110
2003
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Cocco, L.; Martelli, A.M.; Mazzotti, G.; Barnabei, O.; Manzoli, F.A.
Inositides and the nucleus: phospholipase Cbeta family localization and signaling activity
Adv. Enzyme Regul.
40
83-95
2000
Mus musculus
Manually annotated by BRENDA team
Kouchi, Z.; Fukami, K.; Shikano, T.; Oda, S.; Nakamura, Y.; Takenawa, T.; Miyazaki, S.
Recombinant phospholipase Czeta has high Ca2+ sensitivity and induces Ca2+ oscillations in mouse eggs
J. Biol. Chem.
279
10408-10412
2004
Mus musculus, Mus musculus (Q8K4D7), Mus musculus (Q8R3B1)
Manually annotated by BRENDA team
Rebecchi, M.J.; Pentyala, S.N.
Structure, function, and control of phosphoinositide-specific phospholipase C
Physiol. Rev.
80
1291-1335
2000
Arabidopsis thaliana, Saccharomyces cerevisiae, Dictyostelium discoideum, Drosophila sp. (in: flies), Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae PLC1p
Manually annotated by BRENDA team
Hwang, J.I.; Oh, Y.S.; Shin, K.J.; Kim, H.; Ryu, S.H.; Suh, P.G.
Molecular cloning and characterization of a novel phospholipase C, PLC-eta
Biochem. J.
389
181-186
2005
Mus musculus (Q4KWH5), Mus musculus, Homo sapiens (Q4KWH8), Homo sapiens
Manually annotated by BRENDA team
Wang, H.; Oestreich, E.A.; Maekawa, N.; Bullard, T.A.; Vikstrom, K.L.; Dirksen, R.T.; Kelley, G.G.; Blaxall, B.C.; Smrcka, A.V.
Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy
Circ. Res.
97
1305-1313
2005
Mus musculus
Manually annotated by BRENDA team
Martelli, A.M.; Fiume, R.; Faenza, I.; Tabellini, G.; Evangelista, C.; Bortul, R.; Follo, M.Y.; Fala, F.; Cocco, L.
Nuclear phosphoinositide specific phospholipase C (PI-PLC)-beta 1: a central intermediary in nuclear lipid-dependent signal transduction
Histol. Histopathol.
20
1251-1260
2005
Cricetulus griseus, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Stewart, A.J.; Mukherjee, J.; Roberts, S.J.; Lester, D.; Farquharson, C.
Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes
Int. J. Mol. Med.
15
117-121
2005
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Nakahara, M.; Shimozawa, M.; Nakamura, Y.; Irino, Y.; Morita, M.; Kudo, Y.; Fukami, K.
A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme
J. Biol. Chem.
280
29128-29134
2005
Mus musculus (A2AP18)
Manually annotated by BRENDA team
Tassi, I.; Presti, R.; Kim, S.; Yokoyama, W.M.; Gilfillan, S.; Colonna, M.
Phospholipase C-gamma2 is a critical signaling mediator for murine NK cell activating receptors
J. Immunol.
175
749-754
2005
Mus musculus
Manually annotated by BRENDA team
Kim, Y.J.; Sekiya, F.; Poulin, B.; Bae, Y.S.; Rhee, S.G.
Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2
Mol. Cell. Biol.
24
9986-9999
2004
Homo sapiens, Homo sapiens (P16885), Mus musculus, Mus musculus (Q8CIH5)
Manually annotated by BRENDA team
Makranz, C.; Cohen, G.; Baron, A.; Levidor, L.; Kodama, T.; Reichert, F.; Rotshenker, S.
Phosphatidylinositol 3-kinase, phosphoinositide-specific phospholipase-Cgamma and protein kinase-C signal myelin phagocytosis mediated by complement receptor-3 alone and combined with scavenger receptor-AI/II in macrophages
Neurobiol. Dis.
15
279-286
2004
Mus musculus
Manually annotated by BRENDA team
Wang, Y.; Tomar, A.; George, S.P.; Khurana, S.
Obligatory role for phospholipase C-gamma 1 in villin-induced epithelial cell migration
Am. J. Physiol.
292
C1775-C1786
2007
Mus musculus (Q62077)
Manually annotated by BRENDA team
Cocco, L.; Faenza, I.; Fiume, R.; Billi, A.M.; Gilmour, R.S.; Manzoli, F.A.
Phosphoinositide-specific phospholipase C (PI-PLC) beta 1 and nuclear lipid-dependent signaling
Biochim. Biophys. Acta
1761
509-521
2006
Rattus norvegicus (P10687), Mus musculus (Q9Z1B3)
Manually annotated by BRENDA team
Yagisawa, H.; Okada, M.; Naito, Y.; Sasaki, K.; Yamaga, M.; Fujii, M.
Coordinated intracellular translocation of phosphoinositide-specific phospholipase C-delta with the cell cycle
Biochim. Biophys. Acta
1761
522-534
2006
Mus musculus (Q8R3B1)
Manually annotated by BRENDA team
Liu, D.; Liang, H.; Chen, C.; Lin, S.; Zhong, W.; Ho, F.; Hou, W.; Lo, J.; Ho, Y.; Lin, P.; Hung, L.; Liang, Y.
Switch activation of PI-PLC downstream signals in activated macrophages with wortmannin
Biochim. Biophys. Acta
1773
869-879
2007
Mus musculus
Manually annotated by BRENDA team
Lefevre, B.; Pesty, A.; Courtot, A.M.; Martins, C.V.; Broca, O.; Denys, A.; Arnault, E.; Poirot, C.; Avazeri, N.
The phosphoinositide-phospholipase C (PI-PLC) pathway in the mouse oocyte
Crit. Rev. Eukaryot. Gene Expr.
17
259-269
2007
Mus musculus (Q9Z1B3), Mus musculus
Manually annotated by BRENDA team
Faenza, I.; Bregoli, L.; Ramazzotti, G.; Gaboardi, G.; Follo, M.Y.; Mongiorgi, S.; Billi, A.M.; Manzoli, L.; Martelli, A.M.; Cocco, L.
Nuclear phospholipase C beta1 and cellular differentiation
Front. Biosci.
13
2452-2463
2008
Homo sapiens (Q01970), Homo sapiens (Q9NQ66), Mus musculus (Q9Z1B3)
Manually annotated by BRENDA team
Nomikos, M.; Mulgrew-Nesbitt, A.; Pallavi, P.; Mihalyne, G.; Zaitseva, I.; Swann, K.; Lai, F.A.; Murray, D.; McLaughlin, S.
Binding of phosphoinositide-specific phospholipase C-zeta (PLC-zeta) to phospholipid membranes: potential role of an unstructured cluster of basic residues
J. Biol. Chem.
282
16644-16653
2007
Mus musculus
Manually annotated by BRENDA team
Nam, J.H.; Lee, H.; Nguyen, Y.H.; Kang, T.M.; Lee, S.W.; Kim, H.; Kim, S.J.; Earm, Y.E.; Kim, S.J.
Mechanosensitive activation of K+ channel via phospholipase C-induced depletion of phosphatidylinositol 4,5-bisphosphate in B lymphocytes
J. Physiol.
582
977-990
2006
Mus musculus
Manually annotated by BRENDA team
Citro, S.; Malik, S.; Oestreich, E.A.; Radeff-Huang, J.; Kelley, G.G.; Smrcka, A.V.; Brown, J.H.
Phospholipase Cepsilon is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation
Proc. Natl. Acad. Sci. USA
104
15543-15548
2007
Mus musculus (Q8K4S1)
Manually annotated by BRENDA team
Ho, K.K.; Mann, D.J.
Nuclear signaling through phospholipase C and phosphatidylinositol 4,5-bisphosphate
Signal Transduction
6
92-100
2006
Homo sapiens, Mus musculus (Q8R3B1), Mus musculus (Q9Z1B3)
-
Manually annotated by BRENDA team
Ichise, H.; Ichise, T.; Ohtani, O.; Yoshida, N.
Phospholipase Cgamma2 is necessary for separation of blood and lymphatic vasculature in mice
Development
136
191-195
2009
Mus musculus (Q8CIH5), Mus musculus
Manually annotated by BRENDA team
Frei, E.; Hofmann, F.; Wegener, J.W.
Phospholipase C mediated Ca(2+) signals in murine urinary bladder smooth muscle
Eur. J. Pharmacol.
610
106-109
2009
Mus musculus
Manually annotated by BRENDA team
Chen, Y.; Wang, X.; Di, L.; Fu, G.; Chen, Y.; Bai, L.; Liu, J.; Feng, X.; McDonald, J.M.; Michalek, S.; He, Y.; Yu, M.; Fu, Y.X.; Wen, R.; Wu, H.; Wang, D.
Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis
J. Biol. Chem.
283
29593-29601
2008
Mus musculus (Q8CIH5)
Manually annotated by BRENDA team
Xu, S.; Huo, J.; Lee, K.G.; Kurosaki, T.; Lam, K.P.
Phospholipase C{gamma}2 is critical for dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells
J. Biol. Chem.
284
7038-7046
2009
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Lee, J.S.; Yoo, H.; Suh, Y.G.; Jung, J.K.; Kim, J.
Structure-activity relationship of pentacylic triterpene esters from Uncaria rhynchophylla as inhibitors of phospholipase Cgamma1
Planta Med.
74
1481-1487
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Fiume, R.; Teti, G.; Faenza, I.; Cocco, L.
Phosphoinositide-specific phospholipase C beta1 signal transduction in the nucleus
Methods Mol. Biol.
645
143-164
2010
Rattus norvegicus (P10687), Homo sapiens (Q9NQ66), Homo sapiens, Mus musculus (Q9Z1B3)
Manually annotated by BRENDA team
Fukami, K.; Inanobe, S.; Kanemaru, K.; Nakamura, Y.
Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance
Prog. Lipid Res.
49
429-437
2010
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Kim, H.S.; Park, M.Y.; Lee, S.K.; Park, J.S.; Lee, H.Y.; Bae, Y.S.
Activation of formyl peptide receptor 2 by WKYMVm enhances emergency granulopoiesis through phospholipase C activity
BMB Rep.
51
418-423
2018
Mus musculus
Manually annotated by BRENDA team
Jones, K.
Mammalian sperm contain two factors for calcium release and egg activation Phospholipase C zeta and a cryptic activating factor
Mol. Hum. Reprod.
24
465-468
2018
Mus musculus
Manually annotated by BRENDA team
Beziau, D.M.; Toussaint, F.; Blanchette, A.; Dayeh, N.R.; Charbel, C.; Tardif, J.C.; Dupuis, J.; Ledoux, J.
Expression of phosphoinositide-specific phospholipase C isoforms in native endothelial cells
PLoS ONE
10
e0123769
2015
Mus musculus
Manually annotated by BRENDA team