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Adenocarcinoma
A role for phospholipase C-gamma-mediated signaling in tumor cell invasion.
Adenocarcinoma
Bile acid reflux contributes to development of esophageal adenocarcinoma via activation of phosphatidylinositol-specific phospholipase Cgamma2 and NADPH oxidase NOX5-S.
Adenocarcinoma
Conservation of a common motif in enzymes catalyzing ADP-ribose transfer. Identification of domains in mammalian transferases.
Adenocarcinoma
Metastasis of human gastric adenocarcinoma partly depends on phosphoinositide-specific phospholipase ?1 expression.
Adenocarcinoma
Molecular characterization of a glycosylphosphatidylinositol-linked ADP-ribosyltransferase from lymphocytes.
Adenocarcinoma
Novel functional variants locus in PLCE1 and susceptibility to digestive tract cancer in the Chinese population: A meta-analysis.
Adenocarcinoma
Prognostic value of PLCE1 expression in upper gastrointestinal cancer: a systematic review and meta-analysis.
Adenocarcinoma
Regulatory role of arginine 204 in the catalytic activity of rat alloantigens ART2a and ART2b.
Adenocarcinoma
Release of carcinoembryonic antigen from human tumor cells by phosphatidylinositol-specific phospholipase C: highly effective extraction and upregulation from LS-174T colonic adenocarcinoma cells.
Adenocarcinoma
Replication study of PLCE1 and C20orf54 polymorphism and risk of esophageal cancer in a Chinese population.
Adenocarcinoma
The Correlation between Phospholipase C Epsilon (PLCE1) Gene Polymorphisms and Risk of Gastric Adenocarcinoma in Iranian Population.
Adenoma
Overexpression of phospholipase C-gamma 1 in familial adenomatous polyposis.
Adenomatous Polyposis Coli
Growth inhibition by phospholipase C inhibitor peptides of colorectal carcinoma cells derived from familial adenomatous polyposis.
Adenomatous Polyposis Coli
Overexpression of phospholipase C-gamma 1 in familial adenomatous polyposis.
Adenomatous Polyposis Coli
Overexpression of phospholipase C-gamma1 in rat 3Y1 fibroblast cells leads to malignant transformation.
Adrenocortical Carcinoma
Stimulation of guanosine 3',5'-monophosphate-phosphodiesterase activity by adrenocorticotropic hormone-activated increase of guanosine 3',5'-monophosphate in isolated adrenocortical carcinoma cells.
Agammaglobulinemia
Bruton's tyrosine kinase and phospholipase Cgamma2 mediate chemokine-controlled B cell migration and homing.
Agammaglobulinemia
Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain.
Alopecia
Lack of phospholipase C-delta1 induces skin inflammation.
Alopecia
Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development.
Alzheimer Disease
Aberrant accumulation of phospholipase C-delta in Alzheimer brains.
Alzheimer Disease
Aberrant phosphoinositide metabolism in Alzheimer's disease.
Alzheimer Disease
Abnormal accumulation of phospholipase C-delta in filamentous inclusions of human neurodegenerative diseases.
Alzheimer Disease
Alteration of phospholipase C-delta protein level and specific activity in Alzheimer's disease.
Alzheimer Disease
Changes in platelet phospholipase C protein level and activity in Alzheimer's disease.
Alzheimer Disease
Differential involvement of phospholipase C isozymes in Alzheimer's disease.
Alzheimer Disease
Glutamate-induced antigenic changes of phospholipase C-delta in cultured cortical neurons.
Alzheimer Disease
Increase in phospholipase C-delta1 protein levels in aluminum-treated rat brains.
Alzheimer Disease
Phosphatidylinositol-specific phospholipase C activity in the postmortem human brain: no alteration in Alzheimer's disease.
Alzheimer Disease
Phospholipase C isozymes in the human brain and their changes in Alzheimer's disease.
Alzheimer Disease
Reduction of platelet phospholipase C-delta1 activity in Alzheimer's disease associated with a specific apolipoprotein E genotype (epsilon3/epsilon3).
Anemia
Erythropoietin receptor-operated Ca2+ channels: activation by phospholipase C-gamma 1.
Arrhythmias, Cardiac
Oscillatory Ca2+ signaling in the isolated Caenorhabditis elegans intestine: role of the inositol-1,4,5-trisphosphate receptor and phospholipases C beta and gamma.
Arthritis
Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis.
Arthritis
Phospholipase C gamma 2 is critical for development of a murine model of inflammatory arthritis by affecting actin dynamics in dendritic cells.
Arthritis
Vav/Phospholipase Cgamma2-mediated control of a neutrophil-dependent murine model of rheumatoid arthritis.
Asthma
Simultaneous measurement of Ca2+ transients and changes in the cell volume and microviscosity of the plasma membrane in smooth muscle cells. Evaluation of the effect of formoterol.
Astrocytoma
Decrease in thromboxane A2 receptor expression by differentiation with dibutyryl cyclic AMP in 1321N1 human astrocytoma cells.
Astrocytoma
Expression pattern and sub-cellular distribution of phosphoinositide specific phospholipase C enzymes after treatment with U-73122 in rat astrocytoma cells.
Astrocytoma
Human astrocytes contain two distinct angiotensin receptor subtypes.
Astrocytoma
Involvement of phosphatidylcholine-specific phospholipase C in thromboxane A2-induced activation of mitogen-activated protein kinase in astrocytoma cells.
Astrocytoma
Molecular cloning and characterization of PLC-eta2.
Astrocytoma
Muscarinic receptors mediate phospholipase C-dependent activation of protein kinase B via Ca2+, ErbB3, and phosphoinositide 3-kinase in 1321N1 astrocytoma cells.
Astrocytoma
Phospholipase C, protein kinase C, Ca2+/calmodulin-dependent protein kinase II, and redox state are involved in epigallocatechin gallate-induced phospholipase D activation in human astroglioma cells.
Astrocytoma
Protein kinase C modulation of phosphoinositidase C in 1321N1 human astrocytoma cells.
Astrocytoma
Removal of C6 astrocytoma cell surface molecules with phosphatidylinositol phospholipase C: effect on regulation of neural cell adhesion molecule isoforms.
Atherosclerosis
Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice.
Autoimmune Diseases
Apicidin decreases phospholipase C gamma-1 transcript and protein in Hut-78 T lymphoma cells.
Bacterial Infections
Inhibition of phosphoinositide-specific phospholipase C results in the induction of pathogenesis-related genes in soybean.
Bacterial Infections
Phospholipase C-gamma2 is essential for NK cell cytotoxicity and innate immunity to malignant and virally infected cells.
Bone Resorption
Phospholipase Cgamma2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase.
Brain Diseases
Location-dependent role of phospholipase C signaling in the brain: Physiology and pathology.
Brain Injuries
Regional activities of phospholipase C after experimental brain injury in the rat.
Brain Injuries
Regional levels of phospholipase Cgamma after fluid percussion brain injury in the rat.
Brain Ischemia
Alteration of phosphoinositide degradation by cytosolic and membrane-bound phospholipases after forebrain ischemia-reperfusion in gerbil: effects of amyloid beta peptide.
Brain Ischemia
Brain ischemia decreases phosphatidylcholine-phospholipase D but not phosphatidylinositol-phospholipase C in rats.
Breast Neoplasms
A common cofilin activity cycle in invasive tumor cells and inflammatory cells.
Breast Neoplasms
A role for phospholipase C-gamma-mediated signaling in tumor cell invasion.
Breast Neoplasms
Antitumour effects of PLC-gamma1-(SH2)2-TAT fusion proteins on EGFR/c-erbB-2-positive breast cancer cells.
Breast Neoplasms
BetaPix-a enhances the activity of phospholipase Cgamma1 by binding SH3 domain in breast cancer.
Breast Neoplasms
Cells transformed by PLC-gamma 1 overexpression are highly sensitive to clostridium difficile toxin A-induced apoptosis and mitotic inhibition.
Breast Neoplasms
Effects of protein kinase Cdelta and phospholipase C-gamma1 on monocyte chemoattractant protein-1 expression in taxol-induced breast cancer cell death.
Breast Neoplasms
Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas.
Breast Neoplasms
Elevated membrane association of phospholipase C-gamma 1 in MDA-468 mammary tumor cells.
Breast Neoplasms
Expression of phospholipase C-gamma 1 and its transcriptional regulators in breast cancer tissues.
Breast Neoplasms
miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer.
Breast Neoplasms
Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells.
Breast Neoplasms
Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells.
Breast Neoplasms
Phospholipase C-beta 2 promotes mitosis and migration of human breast cancer-derived cells.
Breast Neoplasms
Phospholipase Cgamma1 is required for metastasis development and progression.
Breast Neoplasms
PLC-beta2 is highly expressed in breast cancer and is associated with a poor outcome: a study on tissue microarrays.
Breast Neoplasms
Rebuttal to Letter-to-Editor on 'Distinction between PC-PLC and PI-PLC needs clarification' received for our manuscript titled "Diospyrin derivative, an anticancer quinonoid, regulates apoptosis at endoplasmic reticulum as well as mitochondria by modulating cytosolic calcium in human breast carcinoma cells" [BBRC 417 (2012) 903-909].
Breast Neoplasms
The urokinase plasminogen activator receptor (uPAR) promotes efferocytosis of apoptotic cells.
Bronchial Spasm
Simultaneous measurement of Ca2+ transients and changes in the cell volume and microviscosity of the plasma membrane in smooth muscle cells. Evaluation of the effect of formoterol.
Burkitt Lymphoma
Evidence for nuclear phosphoinositidase C activity in the antiproliferative signals produced by interferon in Burkitt lymphoma cells.
Burkitt Lymphoma
Nuclear phosphoinositide signalling enzyme in human B lymphoid cells.
Burkitt Lymphoma
Phosphoinositidase C beta 1 isoform expression is modulated by interferon alpha in Burkitt lymphoma cells.
Carcinogenesis
Antitumour effects on human colorectal carcinomas cells by stable silencing of phospholipase C-gamma 1 with lentivirus-delivered siRNA.
Carcinogenesis
Association between PLCE1 rs2274223 A > G polymorphism and cancer risk: proof from a meta-analysis.
Carcinogenesis
Association of Potentially Functional Genetic Variants of PLCE1 with Gallbladder Cancer Susceptibility in North Indian Population.
Carcinogenesis
Chemoprevention of colon carcinogenesis by phenylethyl-3-methylcaffeate.
Carcinogenesis
Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester.
Carcinogenesis
Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development.
Carcinogenesis
Crucial role of phospholipase Cepsilon in induction of local skin inflammatory reactions in the elicitation stage of allergic contact hypersensitivity.
Carcinogenesis
Differential expression of phospholipase C epsilon 1 is associated with chronic atrophic gastritis and gastric cancer.
Carcinogenesis
Effect of amount and types of dietary fat on intestinal bacterial 7 alpha-dehydroxylase and phosphatidylinositol-specific phospholipase C and colonic mucosal diacylglycerol kinase and PKC activities during stages of colon tumor promotion.
Carcinogenesis
Genetic and pharmacologic dissection of ras effector utilization in oncogenesis.
Carcinogenesis
Identification of a PLCE1?regulated competing endogenous RNA regulatory network for esophageal squamous cell carcinoma.
Carcinogenesis
Meta-analysis of phospholipase C epsilon 1 polymorphism and cancer risk.
Carcinogenesis
Modulating effect of amount and types of dietary fat on colonic mucosal phospholipase A2, phosphatidylinositol-specific phospholipase C activities, and cyclooxygenase metabolite formation during different stages of colon tumor promotion in male F344 rats.
Carcinogenesis
Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells.
Carcinogenesis
Phospholipase C epsilon 1 (PLCE1 rs2274223A>G, rs3765524C>T and rs7922612C>T) polymorphisms and esophageal cancer risk in the Kashmir Valley.
Carcinogenesis
Phospholipase C epsilon 1 (PLCE1) haplotypes are associated with increased risk of gastric cancer in Kashmir Valley.
Carcinogenesis
Phospholipase C-beta 2 promotes mitosis and migration of human breast cancer-derived cells.
Carcinogenesis
Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis.
Carcinogenesis
PLC-?1 gene polymorphisms significantly enhance the risk of esophageal squamous cell carcinoma in individuals with a family history of upper gastrointestinal cancers.
Carcinogenesis
PLC?1: a potential target of RNA interference therapy for gastric cancer.
Carcinogenesis
PLCE1 rs2274223 A>G polymorphism and cancer risk: a meta-analysis.
Carcinogenesis
Recent advances in understanding the molecular role of phosphoinositide-specific phospholipase C gamma 1 as an emerging onco-driver and novel therapeutic target in human carcinogenesis.
Carcinogenesis
The hamster model of sequential oral oncogenesis.
Carcinoma
A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis.
Carcinoma
CD24, a mucin-type glycoprotein, is a ligand for P-selectin on human tumor cells.
Carcinoma
Characterization of the colorectal carcinoma-associated antigen defined by monoclonal antibody D612.
Carcinoma
Co-expression of alpha(1,3)galactosyltransferase and Bacillus thuringiensis PIPLC enhances hyperacute rejection of tumor cells.
Carcinoma
Comprehensive bioinformatics analysis of the mRNA profile of PLCE1 knockdown in esophageal squamous cell carcinoma.
Carcinoma
Comprehensive bioinformation analysis of the miRNA of PLCE1 knockdown in esophageal squamous cell carcinoma.
Carcinoma
Critical role for the catalytic activity of phospholipase C-gamma1 in epidermal growth factor-induced cell migration.
Carcinoma
Differential expression of a truncated form of the urokinase-type plasminogen-activator receptor in normal and tumor thyroid cells.
Carcinoma
Effect of phosphatidylinositol-specific phospholipase C from Bacillus thuringiensis on solid spinocellular carcinoma.
Carcinoma
Elevated content of phospholipase C-gamma 1 in colorectal cancer tissues.
Carcinoma
Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas.
Carcinoma
Elevated expression patterns and tight correlation of the PLCE1 and NF-?B signaling in Kazakh patients with esophageal carcinoma.
Carcinoma
Expression of a 118 Kd protein in colon carcinoma cells that is immunologically related to PLC-gamma 1 and is augmented by serum-free conditions.
Carcinoma
Expression of phospholipases gamma 1, beta 1, and delta 1 in primary human colon carcinomas and colon carcinoma cell lines.
Carcinoma
Identification of a PLCE1?regulated competing endogenous RNA regulatory network for esophageal squamous cell carcinoma.
Carcinoma
Membrane association and shedding of the GPI-anchored Ca-MOv18 antigen in human ovary carcinoma cells.
Carcinoma
MicroRNA-145 performs as a tumor suppressor in human esophageal squamous cell carcinoma by targeting phospholipase C epsilon 1.
Carcinoma
Multiple polymorphisms within the PLCE1 are associated with esophageal cancer via promoting the gene expression in a Chinese Kazakh population.
Carcinoma
Novel functional variants locus in PLCE1 and susceptibility to digestive tract cancer in the Chinese population: A meta-analysis.
Carcinoma
Novel functional variants locus in PLCE1 and susceptibility to esophageal squamous cell carcinoma: Based on published genome-wide association studies in a central Chinese population.
Carcinoma
Overexpression of phospholipase C-gamma 1 in familial adenomatous polyposis.
Carcinoma
Overexpression of PLCE1 in Kazakh esophageal squamous cell carcinoma: implications in cancer metastasis and aggressiveness.
Carcinoma
Phosphatidylinositol-specific-phospholipase C cleaves urokinase plasminogen activator receptor from the cell surface and leads to inhibition of pemphigus-IgG-induced acantholysis in DJM-1 cells, a squamous cell carcinoma line.
Carcinoma
Phospholipase C gamma 1 regulates the Rap GEF1-Rap1 signalling axis in the control of human prostate carcinoma cell adhesion.
Carcinoma
Phospholipase C-beta 2 promotes mitosis and migration of human breast cancer-derived cells.
Carcinoma
Phospholipase C-gamma1 is required for the epidermal growth factor receptor-induced squamous cell carcinoma cell mitogenesis.
Carcinoma
PLC gamma contributes to metastasis of in situ-occurring mammary and prostate tumors.
Carcinoma
PLC-beta2 is highly expressed in breast cancer and is associated with a poor outcome: a study on tissue microarrays.
Carcinoma
Prognostic value of PLCE1 expression in upper gastrointestinal cancer: a systematic review and meta-analysis.
Carcinoma
Putatively Functional PLCE1 Variants and Susceptibility to Esophageal Squamous Cell Carcinoma (ESCC): A Case-Control Study in Eastern Chinese Populations.
Carcinoma
Release of carcinoembryonic antigen from human tumor cells by phosphatidylinositol-specific phospholipase C: highly effective extraction and upregulation from LS-174T colonic adenocarcinoma cells.
Carcinoma
Replication study of PLCE1 and C20orf54 polymorphism and risk of esophageal cancer in a Chinese population.
Carcinoma
Small cell lung carcinoma exhibits greater phospholipase C-beta1 expression and edelfosine resistance compared with non-small cell lung carcinoma.
Carcinoma
Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma.
Carcinoma
The Ca-MOv18 molecule, a cell-surface marker of human ovarian carcinomas, is anchored to the cell membrane by phosphatidylinositol.
Carcinoma
The SH3 domain, but not the catalytic domain, is required for phospholipase C-gamma1 to mediate epidermal growth factor-induced mitogenesis.
Carcinoma
Topological regulation of cell-membrane phosphoinositidase C.
Carcinoma
Two novel polymorphisms in PLCE1 are associated with the susceptibility to esophageal squamous cell carcinoma in Chinese population.
Carcinoma
[Relationship between rs2274223 and rs3765524 polymorphisms of PLCE1 and risk of esophageal squamous cell carcinoma in a Kazakh Chinese population].
Carcinoma, Hepatocellular
Activation of H2O2-induced VSOR Cl- currents in HTC cells require phospholipase Cgamma1 phosphorylation and Ca2+ mobilisation.
Carcinoma, Hepatocellular
An autocrine factor from Reuber hepatoma cells that stimulates DNA synthesis and acetyl-CoA carboxylase. Characterization of biologic activity and evidence for a glycan structure.
Carcinoma, Hepatocellular
Identification of glycoinositol phospholipids in rat liver by reductive radiomethylation of amines but not in H4IIE hepatoma cells or isolated hepatocytes by biosynthetic labeling with glucosamine.
Carcinoma, Hepatocellular
Phosphoinositide-specific phospholipase C?1 inhibition induces autophagy in human colon cancer and hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Phospholipase C (EC 3.1.4.11): a malignancy linked signal transduction enzyme.
Carcinoma, Hepatocellular
Purification and characterization of a major glycoprotein in rat hepatoma plasma membranes. One of the membrane proteins released by phosphatidylinositol-specific phospholipase C.
Carcinoma, Hepatocellular
Purification and characterization of nuclear phospholipase C specific for phosphoinositides.
Carcinoma, Lobular
PLC-beta2 is highly expressed in breast cancer and is associated with a poor outcome: a study on tissue microarrays.
Carcinoma, Non-Small-Cell Lung
PLCE1 inhibits apoptosis of non-small cell lung cancer via promoting PTEN methylation.
Carcinoma, Non-Small-Cell Lung
Small cell lung carcinoma exhibits greater phospholipase C-beta1 expression and edelfosine resistance compared with non-small cell lung carcinoma.
Carcinoma, Squamous Cell
Critical role for the catalytic activity of phospholipase C-gamma1 in epidermal growth factor-induced cell migration.
Carcinoma, Squamous Cell
EGF-dependent translocation of green fluorescent protein-tagged PLC-gamma1 to the plasma membrane and endosomes.
Carcinoma, Squamous Cell
Epidermal growth factor activates phospholipase C in rat hepatocytes via a different mechanism from that in A431 or rat1hER cells.
Carcinoma, Squamous Cell
Phosphatidylinositol-specific-phospholipase C cleaves urokinase plasminogen activator receptor from the cell surface and leads to inhibition of pemphigus-IgG-induced acantholysis in DJM-1 cells, a squamous cell carcinoma line.
Carcinoma, Squamous Cell
Phospholipase C-gamma1 is required for the epidermal growth factor receptor-induced squamous cell carcinoma cell mitogenesis.
Carcinoma, Squamous Cell
The SH3 domain, but not the catalytic domain, is required for phospholipase C-gamma1 to mediate epidermal growth factor-induced mitogenesis.
Cardiomegaly
Expression of Gq alpha and PLC-beta in scar and border tissue in heart failure due to myocardial infarction.
Cardiomegaly
Losartan attenuates phospholipase C isozyme gene expression in hypertrophied hearts due to volume overload.
Cardiomegaly
Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy.
Cardiomegaly
PKC translocation without changes in Galphaq and PLC-beta protein abundance in cardiac hypertrophy and failure.
Cataract
LncRNA PLCD3-OT1 Functions as a CeRNA to Prevent Age-Related Cataract by Sponging miR-224-5p and Regulating PLCD3 Expression.
Cherubism
SH3BP2 is an activator of NFAT activity and osteoclastogenesis.
Cholera
Actions of phorbol esters on levels of cAMP in cholera toxin-treated chief cells from guinea pig stomach.
Cholera
Characterization of phosphatidylinositol-specific phospholipase C (PI-PLC) from Lilium daviddi pollen.
Cholera
Potentiation by cholera toxin of bradykinin-induced inositol phosphate production in the osteoblast-like cell line MC3T3-E1.
Cholera
Role of a protein regulating guanine nucleotide binding in phosphoinositide breakdown and calcium mobilization by bradykinin in neuroblastoma X glioma hybrid NG108-15 cells: effects of pertussis toxin and cholera toxin on receptor-mediated signal transduction.
Cholera
Signal transduction through the T cell antigen receptor. Activation of phospholipase C through a G protein-independent coupling mechanism.
Cholesteatoma
Expression of phospholipase C-gamma1 in experimental cholesteatoma using Mongolian gerbils.
Cholesteatoma
Signal transduction pathway in human middle ear cholesteatoma.
Choroidal Neovascularization
Role of c-Cbl Dependent Regulation of Phospholipase C gamma 1 Activation in Experimental Choroidal Neovascularization.
Colitis, Ulcerative
Effect of PLC? gene silencing on inhibiting the cancerous transformation of ulcerative colitis.
Colonic Neoplasms
Effect of membrane lipid alteration on the growth, phospholipase C activity and G protein of HT-29 tumor cells.
Colonic Neoplasms
Phosphoinositide-specific phospholipase C?1 inhibition induces autophagy in human colon cancer and hepatocellular carcinoma cells.
Colonic Neoplasms
Reduced expression of phospholipase C-delta, a signal-transducing enzyme, in rat colon neoplasms induced by methylazoxymethanol acetate.
Colonic Neoplasms
Release of carcinoembryonic antigen from human colon cancer cells by phosphatidylinositol-specific phospholipase C.
Colorectal Neoplasms
Antitumour effects on human colorectal carcinomas cells by stable silencing of phospholipase C-gamma 1 with lentivirus-delivered siRNA.
Colorectal Neoplasms
Association between phospholipase C epsilon gene (PLCE1) polymorphism and colorectal cancer risk in a Chinese population.
Colorectal Neoplasms
Cells transformed by PLC-gamma 1 overexpression are highly sensitive to clostridium difficile toxin A-induced apoptosis and mitotic inhibition.
Colorectal Neoplasms
CircPLCE1 facilitates the malignant progression of colorectal cancer by repressing the SRSF2-dependent PLCE1 pre-RNA splicing.
Colorectal Neoplasms
Elevated content of phospholipase C-gamma 1 in colorectal cancer tissues.
Colorectal Neoplasms
Genetic Variations in Phospholipase C-epsilon 1 (PLCE1) and Susceptibility to Colorectal Cancer Risk.
Colorectal Neoplasms
Growth inhibition by phospholipase C inhibitor peptides of colorectal carcinoma cells derived from familial adenomatous polyposis.
Colorectal Neoplasms
NF-kappaB and Hsp70 are involved in the phospholipase Cgamma1 signaling pathway in colorectal cancer cells.
Colorectal Neoplasms
Overexpression of phospholipase C-gamma 1 in colorectal carcinomas is associated with overexpression of factors that bind its promoter.
Colorectal Neoplasms
Overexpression of phospholipase C-gamma 1 in familial adenomatous polyposis.
Colorectal Neoplasms
Overexpression of phospholipase C-gamma1 in rat 3Y1 fibroblast cells leads to malignant transformation.
Colorectal Neoplasms
Phospholipase C epsilon plays a suppressive role in incidence of colorectal cancer.
Colorectal Neoplasms
Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants.
Colorectal Neoplasms
The association between phospholipase C epsilon gene (PLCE1) polymorphisms and colorectal cancer risk in a Chinese Han population: a case-control study.
Colorectal Neoplasms
[Construction of lentivirus producing PLC-gamma1 siRNA and its effect on apoptosis of human colorectal carcinomas cell lines]
Colorectal Neoplasms
[Effects of blocking phospholipase C-gamma1 signaling pathway on proliferation and apoptosis of human colorectal cancer cell line LoVo]
Congenital Abnormalities
Defect in TCR-CD3zeta signaling mediates T cell hypo-responsiveness in mesenteric lymph node.
Craniosynostoses
Sustained platelet-derived growth factor receptor alpha signaling in osteoblasts results in craniosynostosis by overactivating the phospholipase C-gamma pathway.
Dehydration
A gene encoding a phosphatidylinositol-specific phospholipase C is induced by dehydration and salt stress in Arabidopsis thaliana.
Dehydration
AtPLC2, a gene encoding phosphoinositide-specific phospholipase C, is constitutively expressed in vegetative and floral tissues in Arabidopsis thaliana.
Dehydration
Enhanced expression of phospholipase C 1 (ZmPLC1) improves drought tolerance in transgenic maize.
Dermatitis, Contact
Crucial role of phospholipase Cepsilon in induction of local skin inflammatory reactions in the elicitation stage of allergic contact hypersensitivity.
Diabetic Nephropathies
EGFR-PLCgamma1 signaling mediates high glucose-induced PKCbeta1-Akt activation and collagen I upregulation in mesangial cells.
Disseminated Intravascular Coagulation
Phosphatidylinositol-specific phospholipase C, a possible virulence factor of Staphylococcus aureus.
Endometriosis
Expression of phosphoinositide-specific phospholipase C enzymes in normal endometrium and in endometriosis.
Endophthalmitis
Contribution of membrane-damaging toxins to Bacillus endophthalmitis pathogenesis.
Endotoxemia
Disruption of phospholipase C{gamma}1 signalling attenuates cardiac tumor necrosis factor-{alpha} expression and improves myocardial function during endotoxemia.
Endotoxemia
Phospholipase Cgamma1 signalling regulates lipopolysaccharide-induced cyclooxygenase-2 expression in cardiomyocytes.
Epilepsy
Location-dependent role of phospholipase C signaling in the brain: Physiology and pathology.
Escherichia coli Infections
Escherichia coli K-1 interaction with human brain micro-vascular endothelial cells triggers phospholipase C-gamma1 activation downstream of phosphatidylinositol 3-kinase.
Esophageal Neoplasms
A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis.
Esophageal Neoplasms
Heterozygote of PLCE1 rs2274223 increases susceptibility to human papillomavirus infection in patients with esophageal carcinoma among the Kazakh populations.
Esophageal Neoplasms
Hypomethylation-linked activation of PLCE1 impedes autophagy and promotes tumorigenesis through MDM2-mediated ubiquitination and destabilization of p53.
Esophageal Neoplasms
Phospholipase C epsilon 1 (PLCE1 rs2274223A>G, rs3765524C>T and rs7922612C>T) polymorphisms and esophageal cancer risk in the Kashmir Valley.
Esophageal Neoplasms
PLCE1 Polymorphisms and Risk of Esophageal and Gastric Cancer in a Northwestern Chinese Population.
Esophageal Neoplasms
PLCE1 Promotes Esophageal Cancer Cell Progression by Maintaining the Transcriptional Activity of Snail.
Esophageal Neoplasms
PLCE1 Promotes the Invasion and Migration of Esophageal Cancer Cells by Up-Regulating the PKC?/NF-?B Pathway.
Esophageal Neoplasms
PLCE1 suppresses p53 expression in esophageal cancer cells.
Esophageal Squamous Cell Carcinoma
Comprehensive bioinformatics analysis of the mRNA profile of PLCE1 knockdown in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Comprehensive bioinformation analysis of the miRNA of PLCE1 knockdown in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Elevated expression patterns and tight correlation of the PLCE1 and NF-?B signaling in Kazakh patients with esophageal carcinoma.
Esophageal Squamous Cell Carcinoma
Identification of a PLCE1?regulated competing endogenous RNA regulatory network for esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
MicroRNA-145 performs as a tumor suppressor in human esophageal squamous cell carcinoma by targeting phospholipase C epsilon 1.
Esophageal Squamous Cell Carcinoma
Multiple polymorphisms within the PLCE1 are associated with esophageal cancer via promoting the gene expression in a Chinese Kazakh population.
Esophageal Squamous Cell Carcinoma
Novel functional variants locus in PLCE1 and susceptibility to digestive tract cancer in the Chinese population: A meta-analysis.
Esophageal Squamous Cell Carcinoma
Novel functional variants locus in PLCE1 and susceptibility to esophageal squamous cell carcinoma: Based on published genome-wide association studies in a central Chinese population.
Esophageal Squamous Cell Carcinoma
Overexpression of PLCE1 in Kazakh esophageal squamous cell carcinoma: implications in cancer metastasis and aggressiveness.
Esophageal Squamous Cell Carcinoma
Prognostic value of PLCE1 expression in upper gastrointestinal cancer: a systematic review and meta-analysis.
Esophageal Squamous Cell Carcinoma
Putatively Functional PLCE1 Variants and Susceptibility to Esophageal Squamous Cell Carcinoma (ESCC): A Case-Control Study in Eastern Chinese Populations.
Esophageal Squamous Cell Carcinoma
Replication study of PLCE1 and C20orf54 polymorphism and risk of esophageal cancer in a Chinese population.
Esophageal Squamous Cell Carcinoma
Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Two novel polymorphisms in PLCE1 are associated with the susceptibility to esophageal squamous cell carcinoma in Chinese population.
Esophageal Squamous Cell Carcinoma
[Relationship between rs2274223 and rs3765524 polymorphisms of PLCE1 and risk of esophageal squamous cell carcinoma in a Kazakh Chinese population].
Esophagitis
A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis.
Fibroadenoma
Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas.
Gangliosidoses, GM2
Altered phosphoinositide-specific phospholipase C and adenylyl cyclase in brain cortical membranes of cats with GM1 and GM2 gangliosidosis.
Gastritis, Atrophic
Differential expression of phospholipase C epsilon 1 is associated with chronic atrophic gastritis and gastric cancer.
Genetic Diseases, Inborn
Molecular genetic analysis of podocyte genes in focal segmental glomerulosclerosis--a review.
Gingival Overgrowth
Cyclosporin A upregulates phospholipase C beta1 in fibroblasts from gingival overgrowth.
Gingival Overgrowth
Participation of tyrosine kinase and phospholipase Cgamma in isradipine-induced proliferation of cultured human gingival fibroblasts.
Gingival Overgrowth
Plasma cell granuloma in cyclosporine-induced gingival overgrowth: a report of two cases with immunohistochemical positivity of interleukin-6 and phospholipase C-gamma1.
Glioblastoma
Effects of phospholipase Cgamma on Polo-like kinase 1 expression in human glioma cells.
Glioblastoma
Inhibition of phospholipase C-gamma1 activation blocks glioma cell motility and invasion of fetal rat brain aggregates.
Glioma
Differences in the metabolism of inositol and phosphoinositides by cultured cells of neuronal and glial origin.
Glioma
Differential Inhibitory Effects of 2-Azafluorenones on PI-PLC Activation but not on PC-PLC- or PC-PLD-Activation Induced by Histamine, PAF, PMA or A23187 in C6 Glioma Cells.
Glioma
Effects of phospholipase Cgamma on Polo-like kinase 1 expression in human glioma cells.
Glioma
Identification of phospholipase C gamma1 as a protein tyrosine phosphatase mu substrate that regulates cell migration.
Glioma
Inhibition of ecto-ATPase by PPADS, suramin and reactive blue in endothelial cells, C6 glioma cells and RAW 264.7 macrophages.
Glioma
Inhibition of phospholipase C-gamma1 activation blocks glioma cell motility and invasion of fetal rat brain aggregates.
Glioma
Location-dependent role of phospholipase C signaling in the brain: Physiology and pathology.
Glioma
Molecular forms of acetyl- and butyrylcholinesterase in human glioma.
Glioma
Phospholipase C-delta1 expression is linked to proliferation, DNA synthesis, and cyclin E levels.
Glioma
Potentiation of stimulus-induced phosphoinositide breakdown by calmodulin antagonists in C6 glioma cells.
Glioma
T cell receptor-mediated signaling is defective in T cells obtained from patients with primary intracranial tumors.
Glioma
Tissue- and cell type-specific expression of mRNAs for four types of inositol phospholipid-specific phospholipase C.
Glioma
Two forms of phospholipase C-beta 1 generated by alternative splicing.
Glioma
[Sensitization of human glioma SWO cell line to tumor necrosis factor-induced apoptosis by blocking phospholipase C-gamma1 signaling pathway]
Granuloma
Plasma cell granuloma in cyclosporine-induced gingival overgrowth: a report of two cases with immunohistochemical positivity of interleukin-6 and phospholipase C-gamma1.
Granulomatosis with Polyangiitis
Association study with Wegener Granulomatosis of the human phospholipase Cgamma2 gene.
Heart Failure
Changes in sarcolemmal PLC isoenzymes in postinfarct congestive heart failure: partial correction by imidapril.
Heart Failure
Expression of Gq alpha and PLC-beta in scar and border tissue in heart failure due to myocardial infarction.
Heart Failure
Identification of changes in cardiac phospholipase C activity in congestive heart failure.
Heart Failure
Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy.
Hemoglobinuria
CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells.
Hemoglobinuria
Different membrane anchors of Fc gamma RIII (CD16) on K/NK-lymphocytes and neutrophils. Protein- vs lipid-anchor.
Hemoglobinuria
Fc gamma RIII expressed on cultured monocytes is a N-glycosylated transmembrane protein distinct from Fc gamma RIII expressed on natural killer cells.
Hemoglobinuria
H19, a surface membrane molecule involved in T-cell activation, inhibits channel formation by human complement.
Hemoglobinuria
Monocyte antigen CD14 is a phospholipid anchored membrane protein.
Hemoglobinuria, Paroxysmal
CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells.
Hemoglobinuria, Paroxysmal
Different membrane anchors of Fc gamma RIII (CD16) on K/NK-lymphocytes and neutrophils. Protein- vs lipid-anchor.
Hemoglobinuria, Paroxysmal
Fc gamma RIII expressed on cultured monocytes is a N-glycosylated transmembrane protein distinct from Fc gamma RIII expressed on natural killer cells.
Hemoglobinuria, Paroxysmal
H19, a surface membrane molecule involved in T-cell activation, inhibits channel formation by human complement.
Hemoglobinuria, Paroxysmal
Monocyte antigen CD14 is a phospholipid anchored membrane protein.
Hepatitis
Organ-specific attenuation of murine hepatitis virus strain A59 by replacement of catalytic residues in the putative viral cyclic phosphodiesterase ns2.
Herpes Simplex
Reduction of HSV-1 binding to BHK cells after treatment with phosphatidylinositol-specific phospholipase C.
Herpes Zoster
Acetylcholine induces oscillations in intracellular calcium in isolated bovine adrenal zona fasciculata/reticularis cells.
Herpes Zoster
Further characterization of the steroidogenic responsiveness of purified zona fasciculata/reticularis cells from bovine adrenal cortex before and after primary culture: changing responsiveness to phosphoinositidase C agonists.
Herpes Zoster
Immunohistochemical analysis of AT1 receptor versus P450c17 and 3 beta HSD expression in ovine adrenals.
Herpes Zoster
Molecular cloning and characterization of a novel phospholipase C, PLC-eta.
Herpes Zoster
Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate.
Herpes Zoster
Requirement of phospholipase Cdelta4 for the zona pellucida-induced acrosome reaction.
Hodgkin Disease
Expression of intracellular signaling molecules in classical and lymphocyte predominance Hodgkin disease.
Hyperalgesia
GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican.
Hyperalgesia
PLC-beta 3 signals upstream of PKC epsilon in acute and chronic inflammatory hyperalgesia.
Hyperalgesia
Supraspinal Gbetagamma-dependent stimulation of PLCbeta originating from G inhibitory protein-mu opioid receptor-coupling is necessary for morphine induced acute hyperalgesia.
Hypercalcemia
G protein-dependent activation of a phosphoinositide-specific phospholipase C in UMR-106 osteosarcoma cell membranes.
Hypersensitivity
Humoral and delayed-type hypersensitive responses against listeria monocytogenes phosphatidylinositol-specific phospholipase C in experimentally infected buffaloes.
Hypersensitivity
Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice.
Hypersensitivity
Sphingolipid deficiency induces hypersensitivity of CD14, a glycosyl phosphatidylinositol-anchored protein, to phosphatidylinositol-specific phospholipase C.
Hypertension
Alterations of phosphoinositide-specific phospholipase C and protein kinase C in the myocardium of spontaneously hypertensive rats.
Hypertension
Attenuation of renomedullary phospholipase C isozyme, PLC-delta 1, in spontaneously hypertensive rats.
Hypertension
Enhancement of phospholipase C delta 1 activity in the aortas of spontaneously hypertensive rats.
Hypertension
Erythropoietin receptor-operated Ca2+ channels: activation by phospholipase C-gamma 1.
Hypertension
Phospholipase C activity is enhanced in skin fibroblasts obtained from patients with essential hypertension.
Hypertension
Regulation of phospholipase C-delta1 by ARGHAP6, a GTPase-activating protein for RhoA: possible role for enhanced activity of phospholipase C in hypertension.
Hypertension
Renal phospholipase C and diglyceride lipase activity in spontaneously hypertensive rats.
Hyperthyroidism
Effect of thyroid status on phosphatidylinositols in rat heart.
Hypothyroidism
Effect of thyroid status on phosphatidylinositols in rat heart.
Infections
Activation of host phospholipases C and D in macrophages after infection with Listeria monocytogenes.
Infections
Bacillus thuringiensis membrane-damaging toxins acting on mammalian cells.
Infections
Characterization of canine parvovirus (CPV) interactions with 3201 T cells: involvement of GPI-anchored protein(s) in binding and infection.
Infections
Differential function of Listeria monocytogenes listeriolysin O and phospholipases C in vacuolar dissolution following cell-to-cell spread.
Infections
Escherichia coli K-1 interaction with human brain micro-vascular endothelial cells triggers phospholipase C-gamma1 activation downstream of phosphatidylinositol 3-kinase.
Infections
Hantavirus Causing Hemorrhagic Fever with Renal Syndrome Enters from the Apical Surface and Requires Decay-Accelerating Factor (DAF/CD55).
Infections
Humoral and delayed-type hypersensitive responses against listeria monocytogenes phosphatidylinositol-specific phospholipase C in experimentally infected buffaloes.
Infections
Identification of TAF1, SAT1, and ARHGEF9 as DNA methylation biomarkers for hepatocellular carcinoma.
Infections
Inhibition of phosphoinositide-specific phospholipase C results in the induction of pathogenesis-related genes in soybean.
Infections
Intimin-dependent binding of enteropathogenic Escherichia coli to host cells triggers novel signaling events, including tyrosine phosphorylation of phospholipase C-gamma1.
Infections
Listeria monocytogenes evades killing by autophagy during colonization of host cells.
Infections
Listeria monocytogenes phospholipase C-dependent calcium signaling modulates bacterial entry into J774 macrophage-like cells.
Infections
Localization of protein kinase C epsilon to macrophage vacuoles perforated by Listeria monocytogenes cytolysin.
Infections
Macrophage's proinflammatory response to a mycobacterial infection is dependent on sphingosine kinase-mediated activation of phosphatidylinositol phospholipase C, protein kinase C, ERK1/2, and phosphatidylinositol 3-kinase.
Infections
Mobilization of protein kinase C in macrophages induced by Listeria monocytogenes affects its internalization and escape from the phagosome.
Infections
Phosphatidylinositol-specific phospholipase C enhances epidermal penetration by Staphylococcus aureus.
Infections
Phosphatidylinositol-specific phospholipase C of Bacillus anthracis down-modulates the immune response.
Infections
Phosphatidylinositol-specific phospholipase C, a possible virulence factor of Staphylococcus aureus.
Infections
Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors.
Infections
Phospholipase C-gamma1 is required for the induction of immediate early genes by platelet-derived growth factor.
Infections
Phospholipase C/diacylglycerol kinase-mediated signalling is required for benzothiadiazole-induced oxidative burst and hypersensitive cell death in rice suspension-cultured cells.
Infections
PLC-?1 is involved in the inflammatory response induced by influenza A virus H1N1 infection.
Infections
Proteolytic pathways of activation and degradation of a bacterial phospholipase C during intracellular infection by Listeria monocytogenes.
Infections
Rapid activation of protein tyrosine kinase and phospholipase C-gamma2 and increase in cytosolic free calcium are required by Ehrlichia chaffeensis for internalization and growth in THP-1 cells.
Infections
Reduction of HSV-1 binding to BHK cells after treatment with phosphatidylinositol-specific phospholipase C.
Infections
Roles of Listeria monocytogenes virulence factors in survival: virulence factors distinct from listeriolysin are needed for the organism to survive an early neutrophil-mediated host defense mechanism.
Infections
Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody.
Infections
Simian virus 40 infection triggers a balanced network that includes apoptotic, survival, and stress pathways.
Infections
The invasion protein InIB from Listeria monocytogenes activates PLC-gamma1 downstream from PI 3-kinase.
Infections
The listerial exotoxins listeriolysin and phosphatidylinositol-specific phospholipase C synergize to elicit endothelial cell phosphoinositide metabolism.
Infections
Two distinct phospholipases C of Listeria monocytogenes induce ceramide generation, nuclear factor-kappa B activation, and E-selectin expression in human endothelial cells.
Infertility
Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLC?) from an infertile man by use of minisequencing of individual sperm and expression in somatic cells.
Infertility
Essential Role of Sperm-Specific PLC-Zeta in Egg Activation and Male Factor Infertility: An Update.
Infertility
Novel mutations in PLCZ1 cause male infertility due to fertilization failure or poor fertilization.
Infertility
Nuclear Inositide Signaling via Phospholipase C.
Infertility
Oocyte activation, phospholipase C zeta and human infertility.
Infertility
Phospholipase C zeta (PLC?): Oocyte activation and clinical links to male factor infertility.
Infertility, Male
A maternally inherited autosomal point mutation in human phospholipase C zeta (PLC?) leads to male infertility.
Infertility, Male
Increasing associations between defects in phospholipase C zeta and conditions of male infertility: not just ICSI failure?
Infertility, Male
Novel mutations in PLCZ1 cause male infertility due to fertilization failure or poor fertilization.
Infertility, Male
Phospholipase C zeta (PLC?) and male infertility: Clinical update and topical developments.
Infertility, Male
Starting a new life: sperm PLC-zeta mobilizes the Ca2+ signal that induces egg activation and embryo development: an essential phospholipase C with implications for male infertility.
Infertility, Male
The testicular and epididymal expression profile of PLC? in mouse and human does not support its role as a sperm-borne oocyte activating factor.
Influenza, Human
Membrane raft-dependent regulation of phospholipase Cgamma-1 activation in T lymphocytes.
Influenza, Human
PLC-?1 is involved in the inflammatory response induced by influenza A virus H1N1 infection.
Influenza, Human
PLC-?1 signaling plays a subtype-specific role in postbinding cell entry of influenza A virus.
Insulin Resistance
Effect of insulin and insulin-like growth factors I and II on phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate breakdown in liver from humans with and without type II diabetes.
Insulin Resistance
Growth hormone inhibits activation of phosphatidylinositol phospholipase C by insulin in ob/ob mouse adipose tissue.
Insulin Resistance
Hepatic insulin resistance in KKA(y) mice and its amelioration by pioglitazone do not involve alterations in phospholipase C activity.
Insulinoma
Enhanced phosphoinositide hydrolysis via overexpression of phospholipase C beta1 or delta1 inhibits stimulus-induced insulin release in insulinoma MIN6 cells.
Insulinoma
Overexpression of G11alpha and isoforms of phospholipase C in islet beta-cells reveals a lack of correlation between inositol phosphate accumulation and insulin secretion.
Intellectual Disability
Role of Phosphoinositide-Specific Phospholipase C ?2 in Isolated and Syndromic Mental Retardation.
Keratosis, Seborrheic
Altered distribution of phospholipase C-gamma 1 in benign hyperproliferative epidermal diseases.
Kidney Failure, Chronic
Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible.
Leptospirosis
Leptospiral phosphatidylinositol-specific phospholipase C: a novel conserved antigen for the definitive diagnosis of Leptospirosis.
Leukemia
(-)-Epigallocatechin Gallate Regulates CD3-mediated T Cell Receptor Signaling in Leukemia through the Inhibition of ZAP-70 Kinase.
Leukemia
Activation of polyphosphoinositide phospholipase C by guanosine 5'-O-(3-thio)triphosphate and fluoroaluminate in membranes prepared from a human T cell leukemia line, JURKAT.
Leukemia
Characterization of glucocorticoid inhibition of antigen-induced inositolphosphate formation by rat basophilic leukemia cells: possible involvement of phosphatases.
Leukemia
Constitutively activated FGFR3 mutants signal through PLCgamma-dependent and -independent pathways for hematopoietic transformation.
Leukemia
Detergent-resistant membrane domains are required for mast cell activation but dispensable for tyrosine phosphorylation upon aggregation of the high affinity receptor for IgE.
Leukemia
Down-regulation of phospholipase C-gamma 1 during the differentiation of U937 cells.
Leukemia
Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor.
Leukemia
Fc epsilon RI-mediated hydrolysis of phosphoinositides in ghosts derived from rat basophilic leukemia cells.
Leukemia
Glucocorticoid inhibition of antigen-induced inositol phosphate formation: possible involvement of phosphatases.
Leukemia
Identification of functional receptors for ciliary neurotrophic factor on chick ciliary ganglion neurons.
Leukemia
Nuclear inositide signaling: an appraisal of phospholipase C beta1 behavior in myelodysplastic and leukemia cells.
Leukemia
P2-purinergic receptors activate a guanine nucleotide-dependent phospholipase C in membranes from HL-60 cells.
Leukemia
Potent activation of phospholipase D by phenylarsine oxide in rat basophilic leukemia (RBL-2H3) cells.
Leukemia
Purification and characterization of a phosphoinositide-specific phospholipase C from guinea pig uterus. Phosphorylation by protein kinase C in vivo.
Leukemia, Erythroblastic, Acute
Alternative splice variants of phospholipase C-beta2 are expressed in platelets: effect on Galphaq-dependent activation and localization.
Leukemia, Erythroblastic, Acute
Involvement of nuclear PLCbeta1 in lamin B1 phosphorylation and G2/M cell cycle progression.
Leukemia, Erythroblastic, Acute
Molecular forms of acetylcholinesterase in two sublines of human erythroleukemia K562 cells. Sensitivity or resistance to phosphatidylinositol-specific phospholipase C and biosynthesis.
Leukemia, Erythroblastic, Acute
Nuclear phospholipase C beta1 (PLCbeta1) affects CD24 expression in murine erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Phospholipase C treatment of certain human target cells reduces their susceptibility to NK lysis without affecting binding or sensitivity to lytic granules.
Leukemia, Erythroblastic, Acute
Protein kinase C-epsilon is necessary for erythropoietin's up-regulation of c-myc and for factor-dependent DNA synthesis. Evidence for discrete signals for growth and differentiation.
Leukemia, Erythroblastic, Acute
Proteomic-based analysis of nuclear signaling: PLCbeta1 affects the expression of the splicing factor SRp20 in Friend erythroleukemia cells.
Leukemia, Lymphoid
Altered signal transduction secondary to surface IgM cross-linking on B-chronic lymphocytic leukemia cells. Differential activation of the phosphatidylinositol-specific phospholipase C.
Leukemia, Myeloid
Protective role of all-trans retinoic acid (ATRA) against hypoxia-induced malignant potential of non-invasive breast tumor derived cells.
Leukemia, Myeloid, Acute
Inositide-specific phospholipase c beta1 gene deletion in the progression of myelodysplastic syndrome to acute myeloid leukemia.
Leukemia, Myeloid, Acute
Nuclear inositol lipid metabolism: more than just second messenger generation?
Leukemia, Myeloid, Acute
Nuclear phosphoinositide specific phospholipase C (PI-PLC)-beta 1: a central intermediary in nuclear lipid-dependent signal transduction.
Leukemia, Myeloid, Acute
Nuclear phospholipase C beta1, regulation of the cell cycle and progression of acute myeloid leukemia.
Leukemia, Myeloid, Acute
Nuclear phospholipase C: involvement in signal transduction.
Leukemia, Myeloid, Acute
Nuclear PI-PLC ?1 and Myelodysplastic syndromes: from bench to clinics.
Leukemia, Myeloid, Acute
Phosphoinositide phospholipase Cbeta1 (PI-PLCbeta1) gene in myelodysplastic syndromes and cytogenetically normal acute myeloid leukemia: not a deletion, but increased PI-PLCbeta1 expression is an independent prognostic factor.
Leukemia, Myeloid, Acute
Phosphoinositide-phospholipase C beta1 mono-allelic deletion is associated with myelodysplastic syndromes evolution into acute myeloid leukemia.
Leukemia, Myeloid, Acute
Phosphoinositide-specific phospholipase C beta1 signal transduction in the nucleus.
Leukemia, Myeloid, Acute
Synergistic induction of PI-PLC?1 signaling by azacitidine and valproic acid in high-risk myelodysplastic syndromes.
Leukemia, T-Cell
(-)-Epigallocatechin Gallate Regulates CD3-mediated T Cell Receptor Signaling in Leukemia through the Inhibition of ZAP-70 Kinase.
Leukemia, T-Cell
Activation of polyphosphoinositide phospholipase C by guanosine 5'-O-(3-thio)triphosphate and fluoroaluminate in membranes prepared from a human T cell leukemia line, JURKAT.
Leukemia, T-Cell
Phospholipase C treatment of certain human target cells reduces their susceptibility to NK lysis without affecting binding or sensitivity to lytic granules.
Lewy Body Disease
Abnormal accumulation of phospholipase C-delta in filamentous inclusions of human neurodegenerative diseases.
Listeriosis
Role in virulence of phospholipases, listeriolysin O and listeriolysin S from epidemic Listeria monocytogenes using the chicken embryo infection model.
Liver Diseases
Deficient phospholipase C activity in blood polimorphonuclear neutrophils from patients with liver cirrhosis.
Liver Diseases
Phosphoinositide-specific phospholipase C in normal human liver and in alcohol abuse.
Lung Injury
Staphylococcal phosphatidylinositol-specific phospholipase C potentiates lung injury via complement sensitisation.
Lung Neoplasms
Human lung cancer cell lines express cell membrane complement inhibitory proteins and are extremely resistant to complement-mediated lysis; a comparison with normal human respiratory epithelium in vitro, and an insight into mechanism(s) of resistance.
Lung Neoplasms
PLCE1 inhibits apoptosis of non-small cell lung cancer via promoting PTEN methylation.
Lymphoma
A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis.
Lymphoma
Anchoring and degradation of glycolipid-anchored membrane proteins by L929 versus by LM-TK- mouse fibroblasts: implications for anchor biosynthesis.
Lymphoma
Apicidin decreases phospholipase C gamma-1 transcript and protein in Hut-78 T lymphoma cells.
Lymphoma
Calphostin C triggers calcium-dependent apoptosis in human acute lymphoblastic leukemia cells.
Lymphoma
Constitutively activated FGFR3 mutants signal through PLCgamma-dependent and -independent pathways for hematopoietic transformation.
Lymphoma
Deficiency of lymphocyte function-associated antigen 3 (LFA-3) in paroxysmal nocturnal hemoglobinuria. Functional correlates and evidence for a phosphatidylinositol membrane anchor.
Lymphoma
Evidence that murine hematopoietic cell subset marker J11d is attached to a glycosyl-phosphatidylinositol membrane anchor.
Lymphoma
Expression pattern of intracellular leukocyte-associated proteins in primary mediastinal B cell lymphoma.
Lymphoma
Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity.
Lymphoma
Nucleophosmin/B23, a multifunctional protein that can regulate apoptosis.
Lymphoma
Role of c-Cbl Dependent Regulation of Phospholipase C gamma 1 Activation in Experimental Choroidal Neovascularization.
Lymphoma
Sensitivity of receptors for IgA on T560, a murine B lymphoma, to phorbol myristate acetate and to phosphatidylinositol-specific phospholipase C.
Lymphoma
Sodium butyrate causes reexpression of three membrane proteins on glycolipid-anchoring mutants.
Lymphoma
Stimulation of Src family protein-tyrosine kinases as a proximal and mandatory step for SYK kinase-dependent phospholipase Cgamma2 activation in lymphoma B cells exposed to low energy electromagnetic fields.
Lymphoma
Thy-1 supports adhesion of mouse thymocytes to thymic epithelial cells through a Ca2(+)-independent mechanism.
Lymphoma
Tyrosine kinase inhibition in diffuse large B-cell lymphoma: molecular basis for antitumor activity and drug resistance of dasatinib.
Lymphoma, B-Cell
Intracellular signalling molecules as immunohistochemical markers of normal and neoplastic human leucocytes in routine biopsy samples.
Lymphoma, Large-Cell, Anaplastic
Nucleophosmin/B23, a multifunctional protein that can regulate apoptosis.
Lymphoma, T-Cell
Intracellular signalling molecules as immunohistochemical markers of normal and neoplastic human leucocytes in routine biopsy samples.
Malaria
Genetic and transcriptional analysis of phosphoinositide-specific phospholipase C in Plasmodium.
Mastocytoma
Phosphoinositide-specific phospholipase C of a cloned mast cell line, mastocytoma P-815: purification and some characterization.
Melanoma
Characterization of phosphatidylinositol phospholipase C activity in human melanoma.
Melanoma
Expression of protectin (CD59) in human melanoma and its functional role in cell- and complement-mediated cytotoxicity.
Melanoma
Levels of cell membrane CD59 regulate the extent of complement-mediated lysis of human melanoma cells.
Melanoma
Melanotransferrin is efficiently sorted on the surface of exosomes secreted by melanoma cells.
Melanoma
Membrane-bound regulators of complement activation in uveal melanomas. CD46, CD55, and CD59 in uveal melanomas.
Melanoma
Phospholipase C inhibitors: a new class of cytotoxic agents.
Melanoma
The urokinase plasminogen activator receptor (uPAR) promotes efferocytosis of apoptotic cells.
Meningioma
Biochemical properties of acetyl- and butyrylcholinesterase in human meningioma.
Meningioma
Characterization of molecular forms of acetyl- and butyrylcholinesterase in human acoustic neurinomas.
Meningioma
Monomers and dimers of acetylcholinesterase in human meningioma are anchored to the membrane by glycosylphosphatidylinositol.
Meningioma
The epidermal growth factor receptor is associated with phospholipase C-gamma 1 in meningiomas.
Multiple Endocrine Neoplasia
Exclusion of the phosphatidylinositol-specific phospholipase C beta 3 (PLC beta 3) gene as candidate for the multiple endocrine neoplasia type 1 (MEN 1) gene.
Multiple Endocrine Neoplasia
Exclusion of the phosphoinositide-specific phospholipase C beta 3 (PLCB3) gene as a candidate for multiple endocrine neoplasia type 1.
Multiple Endocrine Neoplasia Type 1
Exclusion of the phosphatidylinositol-specific phospholipase C beta 3 (PLC beta 3) gene as candidate for the multiple endocrine neoplasia type 1 (MEN 1) gene.
Multiple Endocrine Neoplasia Type 1
Exclusion of the phosphoinositide-specific phospholipase C beta 3 (PLCB3) gene as a candidate for multiple endocrine neoplasia type 1.
Murine Acquired Immunodeficiency Syndrome
Defective CD4+ T cell signaling in murine AIDS: uncoupling of the T cell receptor complex from PIP2 hydrolysis.
Muscular Dystrophies
In vitro studies on calcium activated phosphatidylinositol phosphodiesterase of erythrocyte ghosts from normal individuals and those with myotonic muscular dystrophy.
Myelodysplastic Syndromes
Deletion of the inositide-specific phospholipase c beta1 gene is a rare event in myelodysplastic syndrome and thus of limited value to predict leukemic progression.
Myelodysplastic Syndromes
Epigenetic regulation of nuclear PI-PLCbeta1 signaling pathway in low-risk MDS patients during azacitidine treatment.
Myelodysplastic Syndromes
Inositide-specific phospholipase c beta1 gene deletion in the progression of myelodysplastic syndrome to acute myeloid leukemia.
Myelodysplastic Syndromes
Inositide-specific phospholipase c beta1 gene deletion is a rare event in myelodysplastic syndromes.
Myelodysplastic Syndromes
Nuclear phospholipase C: involvement in signal transduction.
Myelodysplastic Syndromes
Nuclear PI-PLC ?1 and Myelodysplastic syndromes: from bench to clinics.
Myelodysplastic Syndromes
Phosphoinositide phospholipase Cbeta1 (PI-PLCbeta1) gene in myelodysplastic syndromes and cytogenetically normal acute myeloid leukemia: not a deletion, but increased PI-PLCbeta1 expression is an independent prognostic factor.
Myelodysplastic Syndromes
Phosphoinositide-phospholipase C beta1 mono-allelic deletion is associated with myelodysplastic syndromes evolution into acute myeloid leukemia.
Myelodysplastic Syndromes
Phosphoinositide-specific phospholipase C beta1 signal transduction in the nucleus.
Myelodysplastic Syndromes
Phospholipase C beta1 (PI-PLCbeta1)/Cyclin D3/protein kinase C (PKC) alpha signaling modulation during iron-induced oxidative stress in myelodysplastic syndromes (MDS).
Myelodysplastic Syndromes
Real-time PCR as a tool for quantitative analysis of PI-PLCbeta1 gene expression in myelodysplastic syndrome.
Myelodysplastic Syndromes
Selective Activation of Nuclear PI-PLCbeta1 during Normal and Therapy-Related Differentiation.
Myocardial Infarction
Changes in sarcolemmal PLC isoenzymes in postinfarct congestive heart failure: partial correction by imidapril.
Myocardial Infarction
Expression of Gq alpha and PLC-beta in scar and border tissue in heart failure due to myocardial infarction.
Myocardial Ischemia
Protective effects of protein kinase C during myocardial ischemia require activation of phosphatidyl-inositol specific phospholipase C.
Myocardial Ischemia
[Phosphatidylinositol-specific phospholipase C in hypoxic rat myocardium]
Myotonic Dystrophy
Modulation of nuclear PI-PLCbeta1 during cell differentiation.
Neoplasm Metastasis
Activation of Abl tyrosine kinases promotes invasion of aggressive breast cancer cells.
Neoplasm Metastasis
Antitumour effects of PLC-gamma1-(SH2)2-TAT fusion proteins on EGFR/c-erbB-2-positive breast cancer cells.
Neoplasm Metastasis
Antitumour effects on human colorectal carcinomas cells by stable silencing of phospholipase C-gamma 1 with lentivirus-delivered siRNA.
Neoplasm Metastasis
Lentivirus-mediated PLC?1 gene short-hairpin RNA suppresses tumor growth and metastasis of human gastric adenocarcinoma.
Neoplasm Metastasis
Metastasis of human gastric adenocarcinoma partly depends on phosphoinositide-specific phospholipase ?1 expression.
Neoplasm Metastasis
Phosphoinositide-specific phospholipase C?1 inhibition induces autophagy in human colon cancer and hepatocellular carcinoma cells.
Neoplasm Metastasis
Phospholipase Cgamma1 is required for metastasis development and progression.
Neoplasm Metastasis
Phospholipase Cgamma1 stimulates transcriptional activation of the matrix metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascade.
Neoplasms
1p36.32 rearrangements and the role of PI-PLC ?2 in nervous tumours.
Neoplasms
A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas.
Neoplasms
A role for phospholipase C-gamma-mediated signaling in tumor cell invasion.
Neoplasms
Activation of Abl tyrosine kinases promotes invasion of aggressive breast cancer cells.
Neoplasms
Alkaline phosphodiesterase I release from eucaryotic plasma membranes by phosphatidylinositol-specific phospholipase C. III. The release from tumor cells.
Neoplasms
Amplified increase in signal transduction activity in cancer cells.
Neoplasms
Analysis of the proliferative response to lysophosphatidic acid in primary cultures of mammary epithelium: differences between normal and tumor cells.
Neoplasms
Antitumour effects of PLC-gamma1-(SH2)2-TAT fusion proteins on EGFR/c-erbB-2-positive breast cancer cells.
Neoplasms
BetaPix-a enhances the activity of phospholipase Cgamma1 by binding SH3 domain in breast cancer.
Neoplasms
Biosynthesis of carcinoembryonic antigen (CEA) gene family members expressed in human tumor cell lines: evidence for cleavage of the glycosyl phosphatidyl inositol (GPI) anchor by GPI-PLC and GPI-PLD.
Neoplasms
Btk and phospholipase C gamma 2 can function independently during B cell development.
Neoplasms
Changes in choline metabolism as potential biomarkers of phospholipase C{gamma}1 inhibition in human prostate cancer cells.
Neoplasms
Characterization of phosphatidylinositol phospholipase C activity in human melanoma.
Neoplasms
Chemoprevention of colon carcinogenesis by phenylethyl-3-methylcaffeate.
Neoplasms
Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent.
Neoplasms
Co-expression of alpha(1,3)galactosyltransferase and Bacillus thuringiensis PIPLC enhances hyperacute rejection of tumor cells.
Neoplasms
Construction and identification of eukaryotic expression vector of human full-length PLCgamma1 gene.
Neoplasms
Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester.
Neoplasms
Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development.
Neoplasms
Dietary fat and fiber differentially alter intracellular second messengers during tumor development in rat colon.
Neoplasms
Differential role of neutrophil Fcgamma receptor IIIB (CD16) in phagocytosis, bacterial killing, and responses to immune complexes.
Neoplasms
Effect of amount and types of dietary fat on intestinal bacterial 7 alpha-dehydroxylase and phosphatidylinositol-specific phospholipase C and colonic mucosal diacylglycerol kinase and PKC activities during stages of colon tumor promotion.
Neoplasms
Effect of Phospholipase C-gamma1 Overexpression on the Protein Level of Waf1, PCNA, and Cyclin B1 Following Ultraviolet C Irradiation.
Neoplasms
Effect of PLC? gene silencing on inhibiting the cancerous transformation of ulcerative colitis.
Neoplasms
Enhancement of experimental colon carcinogenesis by dietary 6-phenylhexyl isothiocyanate.
Neoplasms
ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of fcepsilon receptor I-mediated activation of Syk.
Neoplasms
ErbB receptors in the biology and pathology of the aerodigestive tract.
Neoplasms
Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis.
Neoplasms
Exclusion of the phosphatidylinositol-specific phospholipase C beta 3 (PLC beta 3) gene as candidate for the multiple endocrine neoplasia type 1 (MEN 1) gene.
Neoplasms
Exclusion of the phosphoinositide-specific phospholipase C beta 3 (PLCB3) gene as a candidate for multiple endocrine neoplasia type 1.
Neoplasms
Expression and characterization of glycolipid-anchored B7-1 (CD80) from baculovirus-infected insect cells: protein transfer onto tumor cells.
Neoplasms
Expression of intracellular signaling molecules in classical and lymphocyte predominance Hodgkin disease.
Neoplasms
Expression pattern and sub-cellular distribution of phosphoinositide specific phospholipase C enzymes after treatment with U-73122 in rat astrocytoma cells.
Neoplasms
Formation, turnover, and sensitivity to phosphatidylinositol-specific phospholipase C of Thy-1 of a rat neuronal tumor cell line.
Neoplasms
G protein-dependent activation of a phosphoinositide-specific phospholipase C in UMR-106 osteosarcoma cell membranes.
Neoplasms
Growth inhibition, enhancement of intercellular adhesion, and increased expression of carcinoembryonic antigen by overexpression of phosphoinositides-specific phospholipase C beta 1 in LS174T human colon adenocarcinoma cell line.
Neoplasms
Highly effective extraction of carcinoembryonic antigen with phosphatidylinositol-specific phospholipase C.
Neoplasms
Identification of a biochemical lesion, and characteristic response to lipopolysaccharide (LPS) of a cultured macrophage-like cell mutant with defective LPS-binding.
Neoplasms
Identification of phospholipase C gamma1 as a protein tyrosine phosphatase mu substrate that regulates cell migration.
Neoplasms
Increased risk of developing digestive tract cancer in subjects carrying the PLCE1 rs2274223 A>G polymorphism: evidence from a meta-analysis.
Neoplasms
Inhibition of phospholipase C-gamma1 activation blocks glioma cell motility and invasion of fetal rat brain aggregates.
Neoplasms
Inhibition of phospholipase Cgamma1 and cancer cell proliferation by lignans and flavans from Machilus thunbergii.
Neoplasms
Inhibition of phospholipase cgamma1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla.
Neoplasms
Lentivirus-mediated PLC?1 gene short-hairpin RNA suppresses tumor growth and metastasis of human gastric adenocarcinoma.
Neoplasms
Membrane association and shedding of the GPI-anchored Ca-MOv18 antigen in human ovary carcinoma cells.
Neoplasms
Meta-analysis of phospholipase C epsilon 1 polymorphism and cancer risk.
Neoplasms
MicroRNA-145 performs as a tumor suppressor in human esophageal squamous cell carcinoma by targeting phospholipase C epsilon 1.
Neoplasms
Modulating effect of amount and types of dietary fat on colonic mucosal phospholipase A2, phosphatidylinositol-specific phospholipase C activities, and cyclooxygenase metabolite formation during different stages of colon tumor promotion in male F344 rats.
Neoplasms
Molecular inhibition of phospholipase cgamma signaling abrogates DU-145 prostate tumor cell invasion.
Neoplasms
Negative regulatory role of overexpression of PLC gamma 1 in the expression of early growth response 1 gene in rat 3Y1 fibroblasts.
Neoplasms
Overexpression of phosphoinositide-specific phospholipase Cgamma in NIH 3T3 cells promotes transformation and tumorigenicity.
Neoplasms
Phosphoinositide-specific phospholipase C (PI-PLC) in health and disease.
Neoplasms
Phosphoinositide-specific phospholipase C isoforms are conveyed by osteosarcoma-derived extracellular vesicles.
Neoplasms
Phosphoinositide-specific phospholipase C?1 inhibition induces autophagy in human colon cancer and hepatocellular carcinoma cells.
Neoplasms
Phospholipase C (EC 3.1.4.11): a malignancy linked signal transduction enzyme.
Neoplasms
Phospholipase C epsilon 1 (PLCE1 rs2274223A>G, rs3765524C>T and rs7922612C>T) polymorphisms and esophageal cancer risk in the Kashmir Valley.
Neoplasms
Phospholipase C epsilon 1 (PLCE1) haplotypes are associated with increased risk of gastric cancer in Kashmir Valley.
Neoplasms
Phospholipase C gamma 1 (PLCG1) R707Q mutation is counterselected under targeted therapy in a patient with hepatic angiosarcoma.
Neoplasms
Phospholipase C gamma 1 regulates the Rap GEF1-Rap1 signalling axis in the control of human prostate carcinoma cell adhesion.
Neoplasms
Phospholipase C treatment of certain human target cells reduces their susceptibility to NK lysis without affecting binding or sensitivity to lytic granules.
Neoplasms
Phospholipase C-beta 2 promotes mitosis and migration of human breast cancer-derived cells.
Neoplasms
Phospholipase C-gamma1 in tumor progression.
Neoplasms
Phospholipase C? Modulates Rap1 Activity and the Endothelial Barrier.
Neoplasms
Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis.
Neoplasms
Phospholipase Cgamma1 is required for metastasis development and progression.
Neoplasms
Phospholipase Cgamma1 stimulates transcriptional activation of the matrix metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascade.
Neoplasms
Phosphorylation of glycogen synthase kinase-3beta at serine-9 by phospholipase Cgamma1 through protein kinase C in rat 3Y1 fibroblasts.
Neoplasms
PLC-?1 gene polymorphisms significantly enhance the risk of esophageal squamous cell carcinoma in individuals with a family history of upper gastrointestinal cancers.
Neoplasms
PLC-beta2 is highly expressed in breast cancer and is associated with a poor outcome: a study on tissue microarrays.
Neoplasms
PLC? and the RASSF family in tumour suppression and other functions.
Neoplasms
PLCE1 polymorphisms and expression combined with serum AFP level predicts survival of HBV-related hepatocellular carcinoma patients after hepatectomy.
Neoplasms
Possible role of phospholipase C in the regulation of cell division in normal and neoplastic cells.
Neoplasms
Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes.
Neoplasms
Preferential down-regulation of phospholipase C-beta in Ewing's sarcoma cells transfected with antisense EWS-Fli-1.
Neoplasms
Prognostic relevance of MAPK expression in glioblastoma multiforme.
Neoplasms
Protein kinases A and C positively regulate G protein-dependent activation of phosphatidylinositol-specific phospholipase C by tumor necrosis factor-alpha in MC3T3-E1 osteoblasts.
Neoplasms
Proteolytic cleavage of phospholipase C-gamma1 during apoptosis in Molt-4 cells.
Neoplasms
Reduced expression of phospholipase C-delta, a signal-transducing enzyme, in rat colon neoplasms induced by methylazoxymethanol acetate.
Neoplasms
Release of carcinoembryonic antigen from human tumor cells by phosphatidylinositol-specific phospholipase C: highly effective extraction and upregulation from LS-174T colonic adenocarcinoma cells.
Neoplasms
Release of decay-accelerating factor (DAF) from the cell membrane by phosphatidylinositol-specific phospholipase C (PIPLC). Selective modification of a complement regulatory protein.
Neoplasms
Roles of ERK, PI3 kinase, and PLC-gamma pathways induced by overexpression of translationally controlled tumor protein in HeLa cells.
Neoplasms
Semaphorin 4D signalling requires the recruitment of phospholipase C{gamma} into the plexin-B1 receptor complex.
Neoplasms
Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants.
Neoplasms
The CD24/P-selectin binding pathway initiates lung arrest of human A125 adenocarcinoma cells.
Neoplasms
The controversial role of phospholipase C epsilon (PLC?) in cancer development and progression.
Neoplasms
Transformation of rat fibroblasts by phospholipase C-gamma1 overexpression is accompanied by tyrosine dephosphorylation of paxillin.
Neoplasms
Tumor necrosis factor-alpha promotes survival of opossum kidney cells via Cdc42-induced phospholipase C-gamma1 activation and actin filament redistribution.
Neoplasms
Tumor necrosis factor-alpha stimulates phosphatidylinositol breakdown by phospholipase C to coordinately increase the levels of diacylglycerol, free arachidonic acid and prostaglandins in an osteoblast (MC3T3-E1) cell line.
Neoplasms
Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.
Neoplasms
Validation of in vivo pharmacodynamic activity of a novel PDGF receptor tyrosine kinase inhibitor using immunohistochemistry and quantitative image analysis.
Neoplasms
[Expression and Significance of PI-PLC?1 in Colon Cancer].
Neoplasms
[Sensitization of human glioma SWO cell line to tumor necrosis factor-induced apoptosis by blocking phospholipase C-gamma1 signaling pathway]
Nephrotic Syndrome
Cyclosporine A responsive congenital nephrotic syndrome with single heterozygous variants in NPHS1, NPHS2, and PLCE1.
Nephrotic Syndrome
Identification of BRAF as a new interactor of PLCepsilon1, the protein mutated in nephrotic syndrome type 3.
Nephrotic Syndrome
Mutational analysis of the PLCE1 gene in steroid resistant nephrotic syndrome.
Nephrotic Syndrome
PLCE1 regulates the migration, proliferation, and differentiation of podocytes.
Nephrotic Syndrome
Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible.
Neurilemmoma
Characterization of molecular forms of acetyl- and butyrylcholinesterase in human acoustic neurinomas.
Neuroblastoma
Agonist-induced endocytosis of muscarinic cholinergic receptors: relationship to stimulated phosphoinositide turnover.
Neuroblastoma
Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site.
Neuroblastoma
Antagonism by 8-hydroxy-2(di-n-propylamino)tetraline and other serotonin agonists of muscarinic M1-type receptors coupled to inositol phospholipid breakdown in human IMR-32 and SK-N-MC neuroblastoma cells.
Neuroblastoma
Association of solubilized angiotensin II receptors with phospholipase C-alpha in murine neuroblastoma NIE-115 cells.
Neuroblastoma
Bradykinin-induced generation of inositol 1,4,5-trisphosphate in fibroblasts and neuroblastoma cells: effect of pertussis toxin, extracellular calcium, and down-regulation of protein kinase C.
Neuroblastoma
Contribution of G protein activation to fluoride stimulation of phosphoinositide hydrolysis in human neuroblastoma cells.
Neuroblastoma
Epac- and Ca2+ -controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors.
Neuroblastoma
Heterologous desensitization of both phosphoinositide and Ca2+ signaling in SH-SY5Y neuroblastoma cells: a role for intracellular Ca2+ store depletion?
Neuroblastoma
Parkin-mediated Ubiquitination Regulates Phospholipase C-gamma1.
Neuroblastoma
Phosphatidylinositol 4,5-bisphosphate modifies tubulin participation in phospholipase Cbeta1 signaling.
Neuroblastoma
Processing of a cellular prion protein: identification of N- and C-terminal cleavage sites.
Neuroblastoma
Regulation of muscarinic agonist-induced activation of phosphoinositidase C in electrically permeabilized SH-SY5Y human neuroblastoma cells by guanine nucleotides.
Neuroblastoma
Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells.
Neurodegenerative Diseases
Abnormal accumulation of phospholipase C-delta in filamentous inclusions of human neurodegenerative diseases.
Neurodegenerative Diseases
Location-dependent role of phospholipase C signaling in the brain: Physiology and pathology.
Osteolysis
Phospholipase C gamma 2 is critical for development of a murine model of inflammatory arthritis by affecting actin dynamics in dendritic cells.
Osteosarcoma
Evidence for phosphatidylinositol-linked forms of human and avian fibronectin receptors.
Osteosarcoma
Expression of Phosphoinositide-specific phospholipase C enzymes in human osteosarcoma cell lines.
Osteosarcoma
Ezrin silencing remodulates the expression of Phosphoinositide-specific Phospholipase C enzymes in human osteosarcoma cell lines.
Osteosarcoma
Ezrin-related Phosphoinositide pathway modifies RhoA and Rac1 in human osteosarcoma cell lines.
Osteosarcoma
G protein-dependent activation of a phosphoinositide-specific phospholipase C in UMR-106 osteosarcoma cell membranes.
Osteosarcoma
Phosphoinositide-specific phospholipase C isoforms are conveyed by osteosarcoma-derived extracellular vesicles.
Osteosarcoma
Release of alkaline phosphatase from human osteosarcoma cells by phosphatidylinositol phospholipase C: effect of tunicamycin.
Osteosarcoma
Silencing of phosphoinositide-specific phospholipase C ? remodulates the expression of the phosphoinositide signal transduction pathway in human osteosarcoma cell lines.
Ovarian Neoplasms
Membrane association and shedding of the GPI-anchored Ca-MOv18 antigen in human ovary carcinoma cells.
Ovarian Neoplasms
Molecular nature and possible presence of a membranous glycan-phosphatidylinositol anchor of CA125 antigen.
Paralysis
Abnormal accumulation of phospholipase C-delta in filamentous inclusions of human neurodegenerative diseases.
Parkinson Disease
Abnormal accumulation of phospholipase C-delta in filamentous inclusions of human neurodegenerative diseases.
Pemphigus
Phosphatidylinositol-specific-phospholipase C cleaves urokinase plasminogen activator receptor from the cell surface and leads to inhibition of pemphigus-IgG-induced acantholysis in DJM-1 cells, a squamous cell carcinoma line.
Pheochromocytoma
Discrete subcellular localization of phosphoinositidase C beta, gamma and delta in PC12 rat pheochromocytoma cells.
Pheochromocytoma
Hydrogen peroxide induces the activation of the phospholipase C-gamma1 survival pathway in PC12 cells: protective role in apoptosis.
Pheochromocytoma
Immunocytochemical analysis of phosphatidylinositol-specific phospholipase C in PC12 cells: predominance of the delta isoform during neural differentiation.
Pheochromocytoma
Nerve growth factor stimulates the tyrosine phosphorylation of a 38-kDa protein that specifically associates with the src homology domain of phospholipase C-gamma 1.
Pheochromocytoma
Phosphatidylinositol-anchored glycoproteins of PC12 pheochromocytoma cells and brain.
phosphatidylinositol 3-kinase deficiency
Distinct roles of phosphoinositide-3 kinase and phospholipase Cgamma2 in B-cell receptor-mediated signal transduction.
phosphoinositide phospholipase c deficiency
A network analysis of changes in molecular interactions in cellular signaling.
phosphoinositide phospholipase c deficiency
Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis.
phosphoinositide phospholipase c deficiency
Distinct roles of phosphoinositide-3 kinase and phospholipase Cgamma2 in B-cell receptor-mediated signal transduction.
phosphoinositide phospholipase c deficiency
Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis.
phosphoinositide phospholipase c deficiency
Lineage-specific defect in gene expression in human platelet phospholipase C-beta2 deficiency.
phosphoinositide phospholipase c deficiency
Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice.
phosphoinositide phospholipase c deficiency
Phospholipase C gamma 2 is critical for development of a murine model of inflammatory arthritis by affecting actin dynamics in dendritic cells.
phosphoinositide phospholipase c deficiency
Phospholipase C gamma 2 is essential for specific functions of Fc epsilon R and Fc gamma R.
phosphoinositide phospholipase c deficiency
Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors.
phosphoinositide phospholipase c deficiency
Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing.
phosphoinositide phospholipase c deficiency
Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells.
phosphoinositide phospholipase c deficiency
Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance.
phosphoinositide phospholipase c deficiency
Phospholipase C{gamma}2 Mediates RANKL-stimulated Lymph Node Organogenesis and Osteoclastogenesis.
phosphoinositide phospholipase c deficiency
The role of glycosylphosphatidylinositol phospholipase C in membrane trafficking in Trypanosoma brucei.
Pick Disease of the Brain
Abnormal accumulation of phospholipase C-delta in filamentous inclusions of human neurodegenerative diseases.
Pneumonia
NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues.
Prostatic Neoplasms
Caveolin-1 regulates VEGF-stimulated angiogenic activities in prostate cancer and endothelial cells.
Prostatic Neoplasms
Changes in choline metabolism as potential biomarkers of phospholipase C{gamma}1 inhibition in human prostate cancer cells.
Prostatic Neoplasms
Expression and function of the complement membrane attack complex inhibitor protectin (CD59) in human prostate cancer.
Prostatic Neoplasms
OXER1, a G protein-coupled oxoeicosatetraenoid receptor, mediates the survival-promoting effects of arachidonate 5-lipoxygenase in prostate cancer cells.
Protein Deficiency
Expression of T lymphocyte p56(lck), a zinc-finger signal transduction protein, is elevated by dietary zinc deficiency and diet restriction in mice.
Protein-Energy Malnutrition
Expression of T lymphocyte p56(lck), a zinc-finger signal transduction protein, is elevated by dietary zinc deficiency and diet restriction in mice.
Proteinuria
Non-immunologic mechanisms of calcineurin inhibitors explain its antiproteinuric effects in genetic glomerulopathies.
Reperfusion Injury
Alteration of phosphoinositide degradation by cytosolic and membrane-bound phospholipases after forebrain ischemia-reperfusion in gerbil: effects of amyloid beta peptide.
Respiratory Distress Syndrome
Phosphatidylinositol-specific phospholipase C, a possible virulence factor of Staphylococcus aureus.
Retinal Degeneration
Cathepsin proteases mediate photoreceptor cell degeneration in Drosophila.
Retinal Degeneration
cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4).
Retinal Degeneration
Limited role of developmental programmed cell death pathways in Drosophila norpA retinal degeneration.
Retinal Degeneration
Metallophosphoesterase regulates light-induced rhodopsin endocytosis by promoting an association between arrestin and the adaptor protein AP2.
Retinoblastoma
Lipase inactive mutant of PLC-gamma1 regulates NGF-induced neurite outgrowth via enzymatic activity and regulation of cell cycle regulatory proteins.
Sarcoma, Avian
Phospholipase C-gamma 1 associates with viral and cellular src kinases.
Sarcoma, Avian
Sequence similarity of phospholipase C with the non-catalytic region of src.
Sarcoma, Ewing
Preferential down-regulation of phospholipase C-beta in Ewing's sarcoma cells transfected with antisense EWS-Fli-1.
Scrapie
Differential release of cellular and scrapie prion proteins from cellular membranes by phosphatidylinositol-specific phospholipase C.
Seizures
Deletion of phospholipase C beta4 in thalamocortical relay nucleus leads to absence seizures.
Sepsis
Disruption of phospholipase C{gamma}1 signalling attenuates cardiac tumor necrosis factor-{alpha} expression and improves myocardial function during endotoxemia.
Sepsis
The listerial exotoxins listeriolysin and phosphatidylinositol-specific phospholipase C synergize to elicit endothelial cell phosphoinositide metabolism.
Shock, Septic
Early activation events induced by the staphylococcal superantigen toxic shock syndrome toxin-1 in human peripheral blood monocytes.
Shock, Septic
Phosphatidylinositol-specific phospholipase C, a possible virulence factor of Staphylococcus aureus.
Skin Diseases
Phosphatidylinositol-specific phospholipase C enhances epidermal penetration by Staphylococcus aureus.
Small Cell Lung Carcinoma
Small cell lung carcinoma exhibits greater phospholipase C-beta1 expression and edelfosine resistance compared with non-small cell lung carcinoma.
Spasm
Enhanced activity of variant phospholipase C-delta1 protein (R257H) detected in patients with coronary artery spasm.
Squamous Cell Carcinoma of Head and Neck
HIF2{alpha}-mediated activation of the Epidermal Growth Factor Receptor potentiates head and neck cancer cell migration in response to hypoxia.
Status Epilepticus
mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice.
Stomach Neoplasms
Association of Potentially Functional Genetic Variants of PLCE1 with Gallbladder Cancer Susceptibility in North Indian Population.
Stomach Neoplasms
Differential expression of phospholipase C epsilon 1 is associated with chronic atrophic gastritis and gastric cancer.
Stomach Neoplasms
Genetic polymorphism of the phospholipase C epsilon 1 gene and risk of gastric cancer.
Stomach Neoplasms
Phospholipase C epsilon 1 (PLCE1) haplotypes are associated with increased risk of gastric cancer in Kashmir Valley.
Stomach Neoplasms
PLC?1: a potential target of RNA interference therapy for gastric cancer.
Stomach Neoplasms
PLCE1 Polymorphisms and Risk of Esophageal and Gastric Cancer in a Northwestern Chinese Population.
Stomach Neoplasms
Roles of PLC-gamma2 and PKCalpha in TPA-induced apoptosis of gastric cancer cells.
Stomach Neoplasms
The Correlation between Phospholipase C Epsilon (PLCE1) Gene Polymorphisms and Risk of Gastric Adenocarcinoma in Iranian Population.
Stroke
Clinical Features and Related Factors of Poststroke Pathological Laughing and Crying: A Case-Control Study.
Subarachnoid Hemorrhage
Analysis of phospholipase C gene in patients with subarachnoid hemorrhage due to ruptured intracranial saccular aneurysm.
Subarachnoid Hemorrhage
Phospholipase C activity in cerebrospinal fluid following subarachnoid hemorrhage related to brain damage.
Supranuclear Palsy, Progressive
Abnormal accumulation of phospholipase C-delta in filamentous inclusions of human neurodegenerative diseases.
Tabes Dorsalis
Phospholipase cbeta4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum.
Tabes Dorsalis
Roles of phospholipase Cbeta4 in synapse elimination and plasticity in developing and mature cerebellum.
Tangier Disease
Growth and cell cycle abnormalities of fibroblasts from Tangier disease patients.
Teratocarcinoma
Reduced expression of PLC-gamma during the differentiation of mouse F9 teratocarcinoma cells.
Teratozoospermia
Reduced fertilization after ICSI and abnormal phospholipase C zeta presence in spermatozoa from the wobbler mouse.
Teratozoospermia
Reproductive outcome in globozoospermic men: update and prospects.
Teratozoospermia
Subcellular localization of phospholipase C? in human sperm and its absence in DPY19L2-deficient sperm are consistent with its role in oocyte activation.
thioredoxin-dependent peroxiredoxin deficiency
Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II.
Thrombosis
Critical role of FcR gamma-chain, LAT, PLCgamma2 and thrombin in arteriolar thrombus formation upon mild, laser-induced endothelial injury in vivo.
Thrombosis
Dual role of collagen in factor XII-dependent thrombus formation.
Thrombosis
Evaluation of the physiological significance of botrocetin/ von Willebrand factor in vitro signaling.
Thrombosis
Importance of platelet phospholipase Cgamma2 signaling in arterial thrombosis as a function of lesion severity.
Thrombosis
Phospholipase Cgamma2 contributes to stable thrombus formation on VWF.
Thrombosis
Rac1 is essential for phospholipase C-gamma2 activation in platelets.
Thymoma
Removal of lymphocyte surface molecules with phosphatidylinositol-specific phospholipase C: effects on mitogen responses and evidence that ThB and certain Qa antigens are membrane-anchored via phosphatidylinositol.
Trypanosomiasis, African
Glycosylphosphatidylinositol-specific phospholipase C regulates transferrin endocytosis in the African trypanosome.
Urinary Bladder Neoplasms
Knockdown of Phospholipase C-Epsilon by Short-Hairpin RNA-Mediated Gene Silencing Induces Apoptosis in Human Bladder Cancer Cell Lines.
Vaccinia
Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2.
Vaccinia
Molecular cloning, splice variants, expression, and purification of phospholipase C-delta 4.
Vaccinia
Phospholipase C-gamma 1 can induce DNA synthesis by a mechanism independent of its lipase activity.
Vaccinia
Tyrosine phosphorylation of phospholipase C-gamma 1 by vaccinia virus growth factor.
Vascular System Injuries
Platelet hyperreactivity and a prothrombotic phenotype in mice with a gain-of-function mutation in phospholipase Cgamma2.
Vascular System Injuries
Rac1 is essential for phospholipase C-gamma2 activation in platelets.
Virus Diseases
Delineation of the essential function of bovine herpesvirus 1 gD: an indication for the modulatory role of gD in virus entry.
Virus Diseases
Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors.
Virus Diseases
Tec Kinases Itk and Rlk Are Required for CD8+ T Cell Responses to Virus Infection Independent of Their Role in CD4+ T Cell Help.
Whooping Cough
1alpha,25(OH)2D3 causes a rapid increase in phosphatidylinositol-specific PLC-beta activity via phospholipase A2-dependent production of lysophospholipid.
Whooping Cough
Acidification of serotonin-containing secretory vesicles induced by a plasma membrane calcium receptor.
Whooping Cough
Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responses.
Whooping Cough
Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia.
Whooping Cough
Bradykinin modulates potassium and calcium currents in neuroblastoma hybrid cells via different pertussis toxin-insensitive pathways.
Whooping Cough
Bradykinin-induced generation of inositol 1,4,5-trisphosphate in fibroblasts and neuroblastoma cells: effect of pertussis toxin, extracellular calcium, and down-regulation of protein kinase C.
Whooping Cough
Calcium-sensing receptor-mediated activation of phospholipase C-gamma1 is downstream of phospholipase C-beta and protein kinase C in MC3T3-E1 osteoblasts.
Whooping Cough
Characterization of phosphatidylinositol-specific phospholipase C (PI-PLC) from Lilium daviddi pollen.
Whooping Cough
Characterization of the phosphatidylinositol-specific phospholipase C isozymes present in the bovine parathyroid and in human kidney HEK293 cells stably transfected with the human parathyroid Ca2+-sensing receptor.
Whooping Cough
Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2.
Whooping Cough
Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C.
Whooping Cough
Distinctive G protein-dependent signaling in smooth muscle by sphingosine 1-phosphate receptors S1P1 and S1P2.
Whooping Cough
Effects of pertussis toxin on growth factor-stimulated inositol phosphate formation and DNA synthesis in Swiss 3T3 cells.
Whooping Cough
Epidermal growth factor activates phospholipase C in rat hepatocytes via a different mechanism from that in A431 or rat1hER cells.
Whooping Cough
Epidermal growth factor activates phospholipase C-gamma 1 via G(i)1-2 proteins in isolated pancreatic acinar membranes.
Whooping Cough
Epidermal growth factor-induced activation and translocation of phospholipase C-gamma 1 to the cytoskeleton in rat hepatocytes.
Whooping Cough
Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells.
Whooping Cough
Expression of val-12 mutant ras p21 in an IL-3-dependent murine myeloid cell line is associated with loss of serum-dependence and increases in membrane PIP2-specific phospholipase C activity.
Whooping Cough
Extracellular ATP augments mesangial cell growth induced by multiple growth factors.
Whooping Cough
G protein beta gamma subunits. Simplified purification and properties of novel isoforms.
Whooping Cough
Galpha(q/11) and gbetagamma proteins and membrane signaling of calcitriol and estradiol.
Whooping Cough
Ghrelin signalling in guinea-pig femoral artery smooth muscle cells.
Whooping Cough
Growth hormone inhibits activation of phosphatidylinositol phospholipase C in adipose plasma membranes: evidence for a growth hormone-induced change in G protein function.
Whooping Cough
Heterotrimeric Galphaq11 co-immunoprecipitates with surface-anchored GRP78 from plasma membranes of alpha2M*-stimulated macrophages.
Whooping Cough
Isozyme-selective stimulation of phospholipase C-beta 2 by G protein beta gamma-subunits.
Whooping Cough
Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor signals through multiple pathways in endothelial cells.
Whooping Cough
Leukotriene D4-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle.
Whooping Cough
Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in rat insulinoma beta-cells.
Whooping Cough
Membrane signaling and progesterone in female and male osteoblasts. II. Direct involvement of G alpha q/11 coupled to PLC-beta 1 and PLC-beta 3.
Whooping Cough
Muscarinic M3 receptor coupling and regulation.
Whooping Cough
Opioid mu, delta, and kappa receptor-induced activation of phospholipase C-beta 3 and inhibition of adenylyl cyclase is mediated by Gi2 and G(o) in smooth muscle.
Whooping Cough
Pancreastatin activates beta3 isoform of phospholipase C via G(alpha)11 protein stimulation in rat liver membranes.
Whooping Cough
Pertussis toxin stimulates cholecystokinin-induced cyclic AMP formation but is without effect on secretagogue-induced calcium mobilization in exocrine pancreas.
Whooping Cough
Pertussis toxin-sensitive activation of phospholipase A2 can be resolved from phosphoinositidase C in primary cultures of mouse osteoblasts using indomethacin.
Whooping Cough
Pertussis toxin-sensitive Gi protein involvement in epidermal growth factor-induced activation of phospholipase C-gamma in rat hepatocytes.
Whooping Cough
Phospholipase C beta and membrane action of calcitriol and estradiol.
Whooping Cough
Platelet-activating factor (PAF) stimulates phosphatidylinositol hydrolysis in human peripheral blood mononuclear leukocytes.
Whooping Cough
Platelet-activating factor-induced phosphoinositide metabolism in differentiated U-937 cells in culture.
Whooping Cough
Possible involvement of phosphatidylinositol-specific phospholipase C related to pertussis toxin-sensitive GTP-binding proteins during adipocyte differentiation of 3T3-L1 fibroblasts: negative regulation of protein kinase C.
Whooping Cough
Receptor-evoked Cl- current in Xenopus oocytes is mediated through a beta-type phospholipase C. Cloning of a new form of the enzyme.
Whooping Cough
Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells.
Whooping Cough
Role of a protein regulating guanine nucleotide binding in phosphoinositide breakdown and calcium mobilization by bradykinin in neuroblastoma X glioma hybrid NG108-15 cells: effects of pertussis toxin and cholera toxin on receptor-mediated signal transduction.
Whooping Cough
Role of G proteins in activation of phosphoinositide phospholipase C.
Whooping Cough
Serotonin stimulates DNA synthesis in fibroblasts acting through 5-HT1B receptors coupled to a Gi-protein.
Whooping Cough
Signaling networks from Gbeta1 subunit to transcription factors and actin remodeling via a membrane-located ERbeta-related protein in the rapid action of daidzein in osteoblasts.
Whooping Cough
Sphingosine-1-phosphate-induced oxygen free radical generation in smooth muscle cell migration requires Galpha12/13 protein-mediated phospholipase C activation.
Whooping Cough
Studies on the mechanisms of signalling and inhibition by pertussis toxin of fibroblast growth factor-stimulated mitogenesis in Balb/c 3T3 cells.
Whooping Cough
Synergistic activation of phospholipases Cgamma and Cbeta: A novel mechanism for PI3K-independent enhancement of FcepsilonRI-induced mast cell mediator release.
Whooping Cough
The role of G protein methylation in the function of a geranylgeranylated beta gamma isoform.
Whooping Cough
Transfected m2 muscarinic acetylcholine receptors couple to G alpha i2 and G alpha i3 in Chinese hamster ovary cells. Activation and desensitization of the phospholipase C signaling pathway.
Whooping Cough
Transmembrane signalling pathways initiating cell growth in fibroblasts.
Whooping Cough
[Phospholipid metabolism regulated by heterotrimeric G proteins]
Wilms Tumor
Cyclosporine A responsive congenital nephrotic syndrome with single heterozygous variants in NPHS1, NPHS2, and PLCE1.
Wiskott-Aldrich Syndrome
Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains.
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0.006
1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
significant inhibition of PLC-beta with IC50: 0.006 mM, little effect on PLC-beta1, PLC-beta3, or PLC-beta4
0.001 - 0.0666
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
0.0028 - 0.0355
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
0.0021 - 0.0503
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
0.0009 - 0.0441
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
0.0836
3beta-hydroxy-27-4-(E)-2'-dihydrocoumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
pH 7.0, 37°C
0.0008 - 0.0524
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
0.0009 - 0.0737
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
0.1213
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic methyl ester
Homo sapiens
-
pH 7.0, 37°C
0.0017 - 0.059
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
0.0014 - 0.0733
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
0.0001 - 0.0246
adriamycin
0.029
amentoflavone
Homo sapiens
-
pH 7.0, 37°C
additional information
additional information
-
0.001
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in A549 cells, pH 7.0, 37°C
0.0018
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0021
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0021
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, pH 7.0, 37°C
0.003
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in MCF7 cells, pH 7.0, 37°C
0.0054
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HT-1 197 cells, pH 7.0, 37°C
0.0357
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
pH 7.0, 37°C
0.0666
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in CCD-18Co cells, pH 7.0, 37°C
0.0028
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0029
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0029
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, pH 7.0, 37°C
0.0091
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HT-1 197 cells, pH 7.0, 37°C
0.0091
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in MCF7 cells, pH 7.0, 37°C
0.01
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in A549 cells, pH 7.0, 37°C
0.0143
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
pH 7.0, 37°C
0.0355
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in CCD-18Co cells, pH 7.0, 37°C
0.0021
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0021
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, pH 7.0, 37°C
0.0027
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in A549 cells, pH 7.0, 37°C
0.0035
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HT-1 197 cells, pH 7.0, 37°C
0.004
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in MCF7 cells, pH 7.0, 37°C
0.0065
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0446
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
pH 7.0, 37°C
0.0503
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid
Homo sapiens
-
in CCD-18Co cells, pH 7.0, 37°C
0.0009
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in MCF7 cells, pH 7.0, 37°C
0.0038
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0038
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, pH 7.0, 37°C
0.0041
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0043
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in A549 cells, pH 7.0, 37°C
0.0067
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HT-1 197 cells, pH 7.0, 37°C
0.0438
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
in CCD-18Co cells, pH 7.0, 37°C
0.0441
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid
Homo sapiens
-
pH 7.0, 37°C
0.0008
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0008
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, pH 7.0, 37°C
0.0019
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in MCF7 cells, pH 7.0, 37°C
0.002
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0037
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HT-1 197 cells, pH 7.0, 37°C
0.0066
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in A549 cells, pH 7.0, 37°C
0.022
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
pH 7.0, 37°C
0.0524
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in CCD-18Co cells, pH 7.0, 37°C
0.0009
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in MCF7 cells, pH 7.0, 37°C
0.0024
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0038
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in A549 cells, pH 7.0, 37°C
0.0045
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0045
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, pH 7.0, 37°C
0.0051
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HT-1 197 cells, pH 7.0, 37°C
0.0095
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
pH 7.0, 37°C
0.0614
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
sulforhodamine B, cytotoxic effects of 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid on the HCT-15 cell line by the sulforhodamine B (SRB) and colony forming assays, pH 7.0, 37°C
0.065
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in CCD-18Co cells, pH 7.0, 37°C
0.0737
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
colony-forming, cytotoxic effects of 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid on the HCT-15 cell line by the sulforhodamine B (SRB) and colony forming assays, pH 7.0, 37°C
0.0017
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HT-1 197 cells, pH 7.0, 37°C
0.0021
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0021
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0021
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, pH 7.0, 37°C
0.0021
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in MCF7 cells, pH 7.0, 37°C
0.0032
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in A549 cells, pH 7.0, 37°C
0.0277
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
pH 7.0, 37°C
0.059
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid
Homo sapiens
-
in CCD-18Co cells, pH 7.0, 37°C
0.0014
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in MCF7 cells, pH 7.0, 37°C
0.0043
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0043
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HCT-15 cells, pH 7.0, 37°C
0.0047
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0072
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in HT-1 197 cells, pH 7.0, 37°C
0.0076
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in A549 cells, pH 7.0, 37°C
0.0245
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
pH 7.0, 37°C
0.0733
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid
Homo sapiens
-
in CCD-18Co cells, pH 7.0, 37°C
0.0001
adriamycin
Homo sapiens
-
in HT-1 197 cells, pH 7.0, 37°C
0.0004
adriamycin
Homo sapiens
-
colony-forming, cytotoxic effects of 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid on the HCT-15 cell line by the sulforhodamine B (SRB) and colony forming assays, pH 7.0, 37°C
0.0007
adriamycin
Homo sapiens
-
colony-forming, cytotoxic effects of 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid on the A549 cell line by the sulforhodamine B (SRB) and colony forming assays, pH 7.0, 37°C
0.0013
adriamycin
Homo sapiens
-
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0013
adriamycin
Homo sapiens
-
in A549 cells, pH 7.0, 37°C
0.0101
adriamycin
Homo sapiens
-
in CCD-18Co cells, pH 7.0, 37°C
0.0246
adriamycin
Homo sapiens
-
in HCT-15 cells, pH 7.0, 37°C
0.0246
adriamycin
Homo sapiens
-
in HT-1 197 cells, cytotoxic effects in log phase S, pH 7.0, 37°C
0.0246
adriamycin
Homo sapiens
-
sulforhodamine B, cytotoxic effects of 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid on the HCT-15 cell line by the sulforhodamine B (SRB) and colony forming assays, pH 7.0, 37°C
0.006
neomycin
Homo sapiens
-
isoform PLCdelta1, at pH 7.3 and 25°C
0.011
neomycin
Homo sapiens
-
isoform PLCbeta1, at pH 7.3 and 25°C
0.024
neomycin
Homo sapiens
-
isoform PLCgamma1, at pH 7.3 and 25°C
0.4
spermine
Homo sapiens
-
isoform PLCbeta1, at pH 7.3 and 25°C
1.7
spermine
Homo sapiens
-
isoform PLCdelta1, at pH 7.3 and 25°C
4
spermine
Homo sapiens
-
isoform PLCgamma1, at pH 7.3 and 25°C
additional information
additional information
Homo sapiens
-
IC50 value is less than 0.1 microM for adriamycin in MCF7 cells, pH 7.0, 37°C
-
additional information
additional information
Homo sapiens
-
the IC50 values for 3beta,7'-diacetoxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid, 3beta-hydroxyurs-12-en-28-oic 4-(E)-coumaroyl ester, 3beta,27-dihydroxyurs-12-en-28-oic acid, 3beta-4-(E)-coumaroyloxyurs-12-en-28-oic acid, and 4-(E)-coumaric acidare above 0.250 mM, pH 7.0, 37°C
-
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Banno, Y.; Nozawa, Y.
Characterization of partially purified phospholipase C from human platelet membranes
Biochem. J.
248
95-101
1987
Homo sapiens
brenda
Downes, C.P.; Michell, R.H.
The polyphosphoinositide phosphodiesterase of erythrocyte membranes
Biochem. J.
198
133-140
1981
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
brenda
Maraldi, N.M.; Zini, N.; Santi, S.; Bavelloni, A.; Valmori, A.; Marmiroli, S.; Ognibene, A.
Phosphoinositidase C isozymes in SaOS-2 cells: immunocytochemical detection in nuclear and cytoplasmic compartments
Biol. Cell.
79
243-250
1993
Homo sapiens
brenda
Ginger, R.S.; Parker, P.J.
Expression, purification and characterisation of a functional phosphatidylinositol-specific phospholipase C-delta1 protein in Escherichia coli
Eur. J. Biochem.
210
155-160
1992
Homo sapiens
brenda
Carozzi, A.J.; Kriz, R.W.; Webster, C.; Parker, P.J.
Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily
Eur. J. Biochem.
210
521-529
1992
Homo sapiens
brenda
Dawson, R.M.C.; Hemington, N.; Irvine, R.F.
The inhibition of diacylglycerol-stimulated intracellular phospholipases by phospholipids with a phosphocholine-containing polar group. A possible physiological role for sphingomyelin
Biochem. J.
230
61-68
1985
Homo sapiens, Rattus norvegicus
brenda
Sies, W.; Lapetina, E.G.
Properties and distribution of phosphatidylinositol-specific phospholipase C in human and horse platelets
Biochim. Biophys. Acta
752
329-338
1983
Equus caballus, Homo sapiens
brenda
Mauco, G.; Chap, H.; Douste-Blazy, L.
Characterization and properties of a phosphatidylinositol phosphodiesterase (phospholipase C) from platelet cytosol
FEBS Lett.
100
367-370
1979
Homo sapiens
brenda
Roy, G.; Villar, L.M.; Lazaro, I.; Gonzalez, M.; Bootello, A.; Gonzalez-Porque, P.
Purification and properties of membrane and cytosolic phosphatidylinositol-specific phospholipase C from human spleen
J. Biol. Chem.
266
11495-11501
1991
Homo sapiens
brenda
Ochocka, A.M.; Pawelczyk, T.
Isozymes delta of phosphoinositide-specific phospholipase C and their role in signal transduction in the cell
Acta Biochim. Pol.
50
1097-1110
2003
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Rhee, S.G.
Regulation of phosphoinositide-specific phospholipase C
Annu. Rev. Biochem.
70
281-312
2001
Homo sapiens, Mammalia, Rattus norvegicus, Rattus norvegicus PLC-delta1
brenda
Rodriguez, R.; Matsuda, M.; Storey, A.; Katan, M.
Requirements for distinct steps of phospholipase Cgamma2 regulation, membrane-raft-dependent targeting and subsequent enzyme activation in B-cell signalling
Biochem. J.
374
269-280
2003
Homo sapiens
brenda
Caricasole, A.; Sala, C.; Roncarati, R.; Formenti, E.; Terstappen, G.C.
Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLCbeta1)
Biochim. Biophys. Acta
1517
63-72
2000
Homo sapiens (Q9NQ66), Homo sapiens
brenda
Rossi, M.A.; Dianzani, M.U.
Action of 2-nonenal and 4-hydroxynonenal on phosphoinositide-specific phospholipase C in undifferentiated and DMSO-differentiated HL-60 cells
Cell Biochem. Funct.
18
209-214
2000
Homo sapiens
brenda
Zhang, W.; Neer, E.J.
Reassembly of phospholipase C-b2 from separated domains: analysis of basal and G protein-stimulated activities
J. Biol. Chem.
276
2503-2508
2001
Homo sapiens (Q00722)
brenda
Rodriguez, R.; Matsuda, M.; Perisic, O.; Bravo, J.; Paul, A.; Jones, N.P.; Light, Y.; Swann, K.; Williams, R.L.; Katan, M.
Tyrosine residues in phospholipase Cgamma2 essential for the enzyme function in B-cell signaling
J. Biol. Chem.
276
47982-47992
2001
Homo sapiens (P16885), Homo sapiens
brenda
Rebecchi, M.J.; Pentyala, S.N.
Structure, function, and control of phosphoinositide-specific phospholipase C
Physiol. Rev.
80
1291-1335
2000
Arabidopsis thaliana, Saccharomyces cerevisiae, Dictyostelium discoideum, Drosophila sp. (in: flies), Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae PLC1p
brenda
Hwang, J.I.; Oh, Y.S.; Shin, K.J.; Kim, H.; Ryu, S.H.; Suh, P.G.
Molecular cloning and characterization of a novel phospholipase C, PLC-eta
Biochem. J.
389
181-186
2005
Mus musculus (Q4KWH5), Mus musculus, Homo sapiens (Q4KWH8), Homo sapiens
brenda
Lukinovic-Skudar, V.; Donlagic, L.; Banfic, H.; Visnjic, D.
Nuclear phospholipase C-beta1b activation during G2/M and late G1 phase in nocodazole-synchronized HL-60 cells
Biochim. Biophys. Acta
1733
148-156
2005
Homo sapiens
brenda
vom Dorp, F.; Sari, A.Y.; Sanders, H.; Keiper, M.; Oude Weernink, P.A.; Jakobs, K.H.; Schmidt, M.
Inhibition of phospholipase C-epsilon by Gi-coupled receptors
Cell. Signal.
16
921-928
2004
Homo sapiens
brenda
Peng, H.H.; Hodgson, L.; Henderson, A.J.; Dong, C.
Involvement of phospholipase C signaling in melanoma cell-induced endothelial junction disassembly
Front. Biosci.
10
1597-1606
2005
Homo sapiens
brenda
Martelli, A.M.; Fiume, R.; Faenza, I.; Tabellini, G.; Evangelista, C.; Bortul, R.; Follo, M.Y.; Fala, F.; Cocco, L.
Nuclear phosphoinositide specific phospholipase C (PI-PLC)-beta 1: a central intermediary in nuclear lipid-dependent signal transduction
Histol. Histopathol.
20
1251-1260
2005
Cricetulus griseus, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Stewart, A.J.; Mukherjee, J.; Roberts, S.J.; Lester, D.; Farquharson, C.
Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes
Int. J. Mol. Med.
15
117-121
2005
Homo sapiens, Mus musculus
brenda
Piechulek, T.; Rehlen, T.; Walliser, C.; Vatter, P.; Moepps, B.; Gierschik, P.
Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases
J. Biol. Chem.
280
38923-38931
2005
Homo sapiens
brenda
Hou, C.; Kirchner, T.; Singer, M.; Matheis, M.; Argentieri, D.; Cavender, D.
In vivo activity of a phospholipase C inhibitor, 1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione (U73122), in acute and chronic inflammatory reactions
J. Pharmacol. Exp. Ther.
309
697-704
2004
Homo sapiens
brenda
Kim, Y.J.; Sekiya, F.; Poulin, B.; Bae, Y.S.; Rhee, S.G.
Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2
Mol. Cell. Biol.
24
9986-9999
2004
Homo sapiens, Homo sapiens (P16885), Mus musculus, Mus musculus (Q8CIH5)
brenda
Cai, Y.; Stafford, L.J.; Bryan, B.A.; Mitchell, D.; Liu, M.
G-protein-activated phospholipase C-beta, new partners for cell polarity proteins Par3 and Par6
Oncogene
24
4293-4300
2005
Homo sapiens, Rattus norvegicus
brenda
Sorli, S.C.; Bunney, T.D.; Sugden, P.H.; Paterson, H.F.; Katan, M.
Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants
Oncogene
24
90-100
2005
Homo sapiens, Homo sapiens (Q9P212)
brenda
Diaz Anel, A.M.
Phospholipase C beta3 is a key component in the Gbetagamma/PKCeta/PKD-mediated regulation of trans-Golgi network to plasma membrane transport
Biochem. J.
406
157-165
2007
Homo sapiens (Q01970)
brenda
Lukinovic-Skudar, V.; Matkovic, K.; Banfic, H.; Visnjic, D.
Two waves of the nuclear phospholipase C activity in serum-stimulated HL-60 cells during G(1) phase of the cell cycle
Biochim. Biophys. Acta
1771
514-521
2007
Homo sapiens
brenda
Bertagnolo, V.; Benedusi, M.; Brugnoli, F.; Lanuti, P.; Marchisio, M.; Querzoli, P.; Capitani, S.
Phospholipase C-beta 2 promotes mitosis and migration of human breast cancer-derived cells
Carcinogenesis
28
1638-1645
2007
Homo sapiens (Q00722), Homo sapiens
brenda
Brugnoli, F.; Bavelloni, A.; Benedusi, M.; Capitani, S.; Bertagnolo, V.
PLC-beta2 activity on actin-associated polyphosphoinositides promotes migration of differentiating tumoral myeloid precursors
Cell. Signal.
19
1701-1712
2007
Homo sapiens (Q00722)
brenda
Liu, X.; Zhao, Q.; Araki, S.; Zhang, S.; Miao, J.
Contrasting effects of phosphatidylinositol- and phosphatidylcholine-specific phospholipase C on apoptosis in cultured endothelial cells
Endothelium
13
205-211
2006
Homo sapiens
brenda
Faenza, I.; Bregoli, L.; Ramazzotti, G.; Gaboardi, G.; Follo, M.Y.; Mongiorgi, S.; Billi, A.M.; Manzoli, L.; Martelli, A.M.; Cocco, L.
Nuclear phospholipase C beta1 and cellular differentiation
Front. Biosci.
13
2452-2463
2008
Homo sapiens (Q01970), Homo sapiens (Q9NQ66), Mus musculus (Q9Z1B3)
brenda
Alvarez-Breckenridge, C.A.; Waite, K.A.; Eng, C.
PTEN regulates phospholipase D and phospholipase C
Hum. Mol. Genet.
16
1157-1163
2007
Homo sapiens
brenda
Stewart, A.J.; Morgan, K.; Farquharson, C.; Millar, R.P.
Phospholipase C-eta enzymes as putative protein kinase C and Ca2+ signalling components in neuronal and neuroendocrine tissues
Neuroendocrinology
86
243-248
2007
Chlorocebus aethiops, Homo sapiens, Rattus norvegicus
brenda
Ho, K.K.; Mann, D.J.
Nuclear signaling through phospholipase C and phosphatidylinositol 4,5-bisphosphate
Signal Transduction
6
92-100
2006
Homo sapiens, Mus musculus (Q8R3B1), Mus musculus (Q9Z1B3)
-
brenda
Kim, K.Y.; Bang, S.; Han, S.; Nguyen, Y.H.; Kang, T.M.; Kang, K.W.; Hwang, S.W.
TRP-independent inhibition of the phospholipase C pathway by natural sensory ligands
Biochem. Biophys. Res. Commun.
370
295-300
2008
Homo sapiens
brenda
Sala, G.; Dituri, F.; Raimondi, C.; Previdi, S.; Maffucci, T.; Mazzoletti, M.; Rossi, C.; Iezzi, M.; Lattanzio, R.; Piantelli, M.; Iacobelli, S.; Broggini, M.; Falasca, M.
Phospholipase Cgamma1 is required for metastasis development and progression
Cancer Res.
68
10187-10196
2008
Homo sapiens
brenda
Ochocka, A.M.; Grden, M.; Sakowicz-Burkiewicz, M.; Szutowicz, A.; Pawelczyk, T.
Regulation of phospholipase C-delta1 by ARGHAP6, a GTPase-activating protein for RhoA: possible role for enhanced activity of phospholipase C in hypertension
Int. J. Biochem. Cell Biol.
40
2264-2273
2008
Homo sapiens (P51178), Homo sapiens
brenda
Loreto, C.; Carnazza, M.L.; Cardile, V.; Libra, M.; Lombardo, L.; Malaponte, G.; Martinez, G.; Musumeci, G.; Papa, V.; Cocco, L.
Mineral fiber-mediated activation of phosphoinositide-specific phospholipase c in human bronchoalveolar carcinoma-derived alveolar epithelial A549 cells
Int. J. Oncol.
34
371-376
2009
Homo sapiens
brenda
Harita, Y.; Kurihara, H.; Kosako, H.; Tezuka, T.; Sekine, T.; Igarashi, T.; Ohsawa, I.; Ohta, S.; Hattori, S.
Phosphorylation of nephrin triggers Ca2+ signaling by recruitment and activation of phospholipase C-[gamma]1
J. Biol. Chem.
284
8951-8962
2009
Homo sapiens (P19174)
brenda
Hao, J.J.; Liu, Y.; Kruhlak, M.; Debell, K.E.; Rellahan, B.L.; Shaw, S.
Phospholipase C-mediated hydrolysis of PIP2 releases ERM proteins from lymphocyte membrane
J. Cell Biol.
184
451-462
2009
Homo sapiens
brenda
Follo, M.Y.; Finelli, C.; Clissa, C.; Mongiorgi, S.; Bosi, C.; Martinelli, G.; Baccarani, M.; Manzoli, L.; Martelli, A.M.; Cocco, L.
Phosphoinositide-phospholipase C beta1 mono-allelic deletion is associated with myelodysplastic syndromes evolution into acute myeloid leukemia
J. Clin. Oncol.
27
782-790
2009
Homo sapiens (P19174), Homo sapiens (Q15147), Homo sapiens (Q9NQ66), Homo sapiens
brenda
Nelson, C.P.; Nahorski, S.R.; Challiss, R.A.
Temporal profiling of changes in phosphatidylinositol 4,5-bisphosphate, inositol 1,4,5-trisphosphate and diacylglycerol allows comprehensive analysis of phospholipase C-initiated signalling in single neurons
J. Neurochem.
107
602-615
2008
Homo sapiens, Rattus norvegicus
brenda
Thyagarajan, B.; Benn, B.S.; Christakos, S.; Rohacs, T.
Phospholipase C-mediated regulation of transient receptor potential vanilloid 6 channels: implications in active intestinal Ca2+ transport
Mol. Pharmacol.
75
608-616
2009
Homo sapiens
brenda
Lee, J.S.; Yoo, H.; Suh, Y.G.; Jung, J.K.; Kim, J.
Structure-activity relationship of pentacylic triterpene esters from Uncaria rhynchophylla as inhibitors of phospholipase Cgamma1
Planta Med.
74
1481-1487
2008
Homo sapiens, Mus musculus
brenda
Fiume, R.; Teti, G.; Faenza, I.; Cocco, L.
Phosphoinositide-specific phospholipase C beta1 signal transduction in the nucleus
Methods Mol. Biol.
645
143-164
2010
Rattus norvegicus (P10687), Homo sapiens (Q9NQ66), Homo sapiens, Mus musculus (Q9Z1B3)
brenda
Fukami, K.; Inanobe, S.; Kanemaru, K.; Nakamura, Y.
Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance
Prog. Lipid Res.
49
429-437
2010
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
van Veen, M.; Mans, L.A.; Matas-Rico, E.; van Pelt, J.; Perrakis, A.; Moolenaar, W.H.; Haramis, A.G.
Glycerophosphodiesterase GDE2/GDPD5 affects pancreas differentiation in zebrafish
Int. J. Biochem. Cell Biol.
94
71-78
2018
Danio rerio (E9QG52), Danio rerio (X1WHY1), Homo sapiens (Q8WTR4)
brenda
Smrcka, A.V.
Regulation of phosphatidylinositol-specific phospholipase C at the nuclear envelope in cardiac myocytes
J. Cardiovasc. Pharmacol.
65
203-210
2015
Homo sapiens
brenda
Di Raimo, T.; Leopizzi, M.; Mangino, G.; Rocca, C.D.; Businaro, R.; Longo, L.; Lo Vasco, V.R.
Different expression and subcellular localization of phosphoinositide-specific phospholipase C enzymes in differently polarized macrophages
J. Cell Commun. Signal.
10
283-293
2016
Homo sapiens
brenda
Fais, P.; Leopizzi, M.; Di Maio, V.; Longo, L.; Della Rocca, C.; Tagliaro, F.; Bortolotti, F.; Lo Vasco, V.R.
Phosphoinositide-specific phospholipase C in normal human liver and in alcohol abuse
J. Cell. Biochem.
120
7907-7917
2018
Homo sapiens
brenda
Cocco, L.; Follo, M.Y.; Manzoli, L.; Suh, P.G.
Phosphoinositide-specific phospholipase C in health and disease
J. Lipid Res.
56
1853-1860
2015
Homo sapiens
brenda
Seo, J.B.; Jung, S.R.; Huang, W.; Zhang, Q.; Koh, D.S.
Charge shielding of PIP2 by cations regulates enzyme activity of phospholipase C
PLoS ONE
10
e0144432
2015
Homo sapiens
brenda