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IUBMB CommentsThe enzyme also has low activity with N7-methyl-GDP, producing N7-methyl-GMP. Does not accept AMP or GMP, and has low activity with UMP.
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
cniii-like, cg3362, cytosolic nucleotidase iii-like,
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cytosolic 5'-nucleotidase 3
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cytosolic nucleotidase III-like
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N7-methylguanylate 5'-phosphatase
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N7-methyl-GMP phosphohydrolase
The enzyme also has low activity with N7-methyl-GDP, producing N7-methyl-GMP. Does not accept AMP or GMP, and has low activity with UMP.
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N7-methyl-GDP + H2O
N7-methyl-guanosine + 2 phosphate
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37fold less efficient than reaction with N7-methyl-GMP
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N7-methyl-GMP + H2O
N7-methyl-guanosine + phosphate
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enzyme cleaves m7GMP to 7-methylguanosine and phosphate
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additional information
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additional information
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enzyme also efficiently dephosphorylates CMP, Reaction of EC 3.1.3.5. UMP is a reasonable substrate, and the purine nucleotides are poor substrates
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additional information
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enzyme also efficiently dephosphorylates CMP, Reaction of EC 3.1.3.5. UMP is a reasonable substrate, and the purine nucleotides are poor substrates
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0.0078
N7-methyl-GMP
pH 7.5, 37°C
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0.24
N7-methyl-GMP
pH 7.5, 37°C
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0.3
N7-methyl-GMP
pH 7.5, 37°C
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UniProt
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5NT3A_HUMAN
336
1
37948
Swiss-Prot
Mitochondrion (Reliability: 5)
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34000
analytical ultracentrifugation
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monomer
34400, calculated
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expression in Escherichia coli
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Buschmann, J.; Moritz, B.; Jeske, M.; Lilie, H.; Schierhorn, A.; Wahle, E.
Identification of Drosophila and human 7-methyl GMP-specific nucleotidases
J. Biol. Chem.
288
2441-2451
2013
Drosophila melanogaster (Q9W197), Homo sapiens (Q9H0P0), Homo sapiens
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