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Information on EC 3.1.3.9 - glucose-6-phosphatase and Organism(s) Mus musculus and UniProt Accession Q9Z186
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3.1.3.9 glucose-6-phosphataseIUBMB Comments
Wide distribution in animal tissues. Also catalyses potent transphosphorylations from carbamoyl phosphate, hexose phosphates, diphosphate, phosphoenolpyruvate and nucleoside di- and triphosphates, to D-glucose, D-mannose, 3-methyl-D-glucose or 2-deoxy-D-glucose [cf. EC 2.7.1.62 (phosphoramidate---hexose phosphotransferase), EC 2.7.1.79 (diphosphate---glycerol phosphotransferase) and EC 3.9.1.1 (phosphoamidase)].
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Word Map
- 3.1.3.9
- glycogen
-
gluconeogenesis
- phosphoenolpyruvate
-
carboxykinase
- hepatocytes
- pepck
-
gluconeogenic
- hyperglycemia
- glucokinase
- hexokinase
- triglyceride
- cholesterol
- succinate
- fructose
- wistar
- glucagon
- mellitus
- pancreatic
- streptozotocin
-
high-fat
-
antidiabetic
-
cytochemical
- 5'-nucleotidase
-
hypoglycemic
-
streptozotocin-induced
- fructose-1,6-bisphosphatase
-
glycogenolysis
- metformin
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amp-activated
- transpeptidase
-
periportal
-
preneoplastic
-
phosphofructokinase
- translocase
-
lipogenesis
-
hepatocarcinogenesis
- ccl4
- hepatomegaly
-
antihyperglycemic
- triphosphatase
-
gamma-glutamyl
-
forkhead
-
perivenous
-
chrebp
- medicine
- fbpase
-
glycogenesis
- diethylnitrosamine
-
hyperuricemia
-
1,6-bisphosphatase
-
cytochemistry
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
glucose-6-phosphatase, g6pase, glucose 6-phosphatase, g-6-pase, g6pc2, islet-specific glucose-6-phosphatase catalytic subunit-related protein, g6pc1, g6pase-alpha, glucose-6-phosphatase-alpha, g6pase-beta, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
G-6-Pase
-
-
-
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G6Pase
G6PC
glucose 6-phosphate phosphatase
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-
-
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glucose 6-phosphate phosphohydrolase
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-
-
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phosphatase, glucose 6-
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-
-
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G6Pase
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
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-
-
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PATHWAY SOURCE
PATHWAYS
KEGG
-
-
SYSTEMATIC NAME
IUBMB Comments
D-glucose-6-phosphate phosphohydrolase
Wide distribution in animal tissues. Also catalyses potent transphosphorylations from carbamoyl phosphate, hexose phosphates, diphosphate, phosphoenolpyruvate and nucleoside di- and triphosphates, to D-glucose, D-mannose, 3-methyl-D-glucose or 2-deoxy-D-glucose [cf. EC 2.7.1.62 (phosphoramidate---hexose phosphotransferase), EC 2.7.1.79 (diphosphate---glycerol phosphotransferase) and EC 3.9.1.1 (phosphoamidase)].
CAS REGISTRY NUMBER
COMMENTARY
9001-39-2
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
the role of the enzyme in muscle is either to produce glucose from glucose 6-phosphate derived from glycogen or to provide the enzymatic basis for a substrate cycle betwen glucose and glucose 6-phosphate in muscle to improve the sensitivity of the mechanism that regulates the rate of glucose phosphorylation
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-
?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
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the enzyme is required for the final steps of glycogenolysis and gluconeogenesis
-
?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
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the brain functional glucose-6-phosphatase complex is capable of endogenous glucose production from glucose 6-phosphate, independent of blood glucose
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
the role of the enzyme in muscle is either to produce glucose from glucose 6-phosphate derived from glycogen or to provide the enzymatic basis for a substrate cycle betwen glucose and glucose 6-phosphate in muscle to improve the sensitivity of the mechanism that regulates the rate of glucose phosphorylation
-
-
?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
-
the enzyme is required for the final steps of glycogenolysis and gluconeogenesis
-
?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
-
the brain functional glucose-6-phosphatase complex is capable of endogenous glucose production from glucose 6-phosphate, independent of blood glucose
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
tumor necrosis factor inhibits the transcriptional rate of glucose-6-phosphatase in vivo and in vitro
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additional information
-
insulin and epidermal growth factor inhibit basal mouse G6Pase fusion gene transcription
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
Foxa2 and MafA but not Pdx-1 directly regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression. Pdx-1, Foxa2, and MafA binding is required for maximal IGRP promoter activity.
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additional information
-
Foxa2 and MafA but not Pdx-1 directly regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression. Pdx-1, Foxa2, and MafA binding is required for maximal IGRP promoter activity.
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additional information
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Foxo1 synergizes with HNF-4 in activating the G6Pase gene transcription
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additional information
peroxisome proliferator activated receptor gamma coactivator-1alpha stimulates mouse G6pc-luciferase fusion gene expression through hepatocyte nuclear factor-4alpha
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additional information
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peroxisome proliferator activated receptor gamma coactivator-1alpha stimulates mouse G6pc-luciferase fusion gene expression through hepatocyte nuclear factor-4alpha
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
two enzyme forms: an acid-sensitive Glc-6-Pase-alpha in liver, kidney and intestine, and an acid-insensitive Glc-6-Pase-beta in astroctyes
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
contains a functional glucose-6-phosphatase complex capable of endogenous glucose production from glucose 6-phosphate, independent of blood glucose
additional information
-
-
additional information
-
the enzyme is expressed in beta-cells of pancreatic islets and in intestinal musoca, most particulary in the starved and diabetic states
additional information
-
expression of the enzyme and of glucose 6-phosphate transporter, overview, two enzyme forms: an acid-sensitive Glc-6-Pase-alpha in liver, kidney and intestine, and an acid-insensitive Glc-6-Pase-beta in astrocytes, overview
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
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glycogen storage disease type Ia characterized by impaired glucose homeostasis and chronic risk of hepatocellular adenoma, is caused by a deficiency in glucose-6-phosphatase-alpha activity
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). G6PC2_MOUSE
355
6
40681
Swiss-Prot
other Location (Reliability: 2)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloning into an andoviral vector of nontagged or FLAG-tagged beta-subunit, expression in COS-1 cells
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the expression of hepatic enzyme catalytic subunit in pancreatic islets is studied
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nordlie, R.C.; Sukalski, K.A.
Multifunctional glucose 6-phosphatase: a critical review
The Enzymes of Biological Membranes, 2nd Ed. (Martonosi, A. V. , ed. ), Plenum, New York
2
349-398
1985
Bos taurus, Cyprinus carpio, Cavia porcellus, Gallus gallus, Cricetulus griseus, Oryctolagus cuniculus, Dictyostelium discoideum, Felis catus, Frog, Homo sapiens, Vicugna pacos, Lampetra ayresii, Platyrrhini, Mus musculus, Oncorhynchus mykiss, Rattus norvegicus, salamander
-
Surholt, B.; Newsholme, E.A.
Maximum activities and properties of glucose 6-phosphatase in muscles from vertebrates and invertebrates
Biochem. J.
198
621-629
1981
Acherontia atropos, Agrotis exclamationis, Nymphalis urticae, Apis mellifera, Arctia caja, Bombus hortorum, Bombus pascuorum, Bombus terrestris, Bombyx mori, Calliphora vicina, Cavia porcellus, Gallus gallus, Columba livia, Crangon crangon, Oryctolagus cuniculus, Deilephila elpenor, Schistocerca gregaria, Laothoe populi, Locusta migratoria, Manduca sexta, Mus musculus, Musca domestica, Alitta virens, Noctua pronuba, Pachnoda ephippiata, Passer domesticus, Phalera bucephala, Protophormia terraenovae, Phryganea sp., Pieris brassicae, Bombus vestalis, Rana temporaria, Rattus norvegicus, Sarcophaga barbata, Spilarctia lutea, Vespa vulgaris, Xenopus laevis
Nordlie, R.C.; Jorgenson, R.A.
Glucose-6-phosphatase
The Enzymes of Biological Membranes (Martonosi, A. V. , ed. ) Plenum, New York
2
465-491
1976
Anas platyrhynchos, Bos taurus, Canis lupus familiaris, Gallus gallus, Columba livia, Cottus gobio, Oryctolagus cuniculus, Cervidae, Felis catus, Chondrichthyes, Ovis aries, Homo sapiens, Trochilidae, Mus musculus, Necturus maculosus, Lithobates catesbeianus, Rana sp., Rattus norvegicus, Thamnophis sirtalis, Turtle
-
Metzger, S.; Begleibter, N.; Barash, V.; Drize, O.; Peretz, T.; Shiloni, E.; Chajek-Shaul, T.
Tumor necrosis factor inhibits the transcriptional rate of glucose-6-phosphatase in vivo and in vitro
Metabolism
46
579-583
1997
Mus musculus
Nordlie, R.C.
Metabolic regulation by multifunctional glucose-6-phosphatase
Curr. Top. Cell. Regul.
8
33-117
1974
Anas platyrhynchos, Canis lupus familiaris, Cavia porcellus, Gallus gallus, Columba livia, Oryctolagus cuniculus, Cervidae, Felis catus, Chondrichthyes, Ovis aries, Homo sapiens, Trochilidae, Mus musculus, Necturus maculosus, Lithobates catesbeianus, Rana sp., Rattus norvegicus, Thamnophis sirtalis, Turtle
Nordlie, R.C.
Glucose-6-phosphatase, hydrolytic and synthetic activities
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
4
543-610
1971
Anas platyrhynchos, Bos taurus, Canis lupus familiaris, Cavia porcellus, Gallus gallus, Columba livia, Astacoidea, Oryctolagus cuniculus, Equus caballus, Felis catus, Frog, Ovis aries, Homo sapiens, Lampetra sp., Marmota sp., Mesocricetus auratus, Platyrrhini, Mus musculus, Necturus maculosus, Rattus norvegicus, Sus scrofa
-
Goh, B.H.; Efendic, S.; Khan, A.; Portwood, N.
Evidence for the expression of both the hydrolase and translocase components of hepatic glucose-6-phosphatase in murine pancreatic islets
Biochem. Biophys. Res. Commun.
307
935-941
2003
Mus musculus
Van Schaftingen, E.; Gerin, I.
The glucose-6-phosphatase system
Biochem. J.
362
513-532
2002
Homo sapiens, Mus musculus, Rattus norvegicus
Ghosh, A.; Cheung, Y.Y.; Mansfield, B.C.; Chou, J.Y.
Brain contains a functional glucose-6-phosphatase complex capable of endogenous glucose production
J. Biol. Chem.
280
11114-11119
2005
Mus musculus
Onuma, H.; Oeser, J.K.; Nelson, B.A.; Wang, Y.; Flemming, B.P.; Scheving, L.A.; Russell, W.E.; OBrien, R.M.
Insulin and epidermal growth factor suppress basal glucose-6-phosphatase catalytic subunit gene transcription through overlapping but distinct mechanisms
Biochem. J.
417
611-620
2009
Mus musculus
Wang, Y.; Flemming, B.P.; Martin, C.C.; Allen, S.R.; Walters, J.; Oeser, J.K.; Hutton, J.C.; OBrien, R.M.
Long-range enhancers are required to maintain expression of the autoantigen islet-specific glucose-6-phosphatase catalytic subunit-related protein in adult mouse islets in vivo
Diabetes
57
133-141
2008
Mus musculus
Schilling, M.M.; Oeser, J.K.; Chandy, J.K.; Flemming, B.P.; Allen, S.R.; OBrien, R.M.
Sequence variation between the mouse and human glucose-6-phosphatase catalytic subunit gene promoters results in differential activation by peroxisome proliferator activated receptor gamma coactivator-1alpha
Diabetologia
51
1505-1514
2008
Mus musculus (P35576), Mus musculus
Hirota, K.; Sakamaki, J.; Ishida, J.; Shimamoto, Y.; Nishihara, S.; Kodama, N.; Ohta, K.; Yamamoto, M.; Tanimoto, K.; Fukamizu, A.
A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding
J. Biol. Chem.
283
32432-32441
2008
Homo sapiens, Mus musculus
Martin, C.C.; Flemming, B.P.; Wang, Y.; Oeser, J.K.; OBrien, R.M.
Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression
J. Mol. Endocrinol.
41
315-328
2008
Mus musculus (Q9Z186), Mus musculus
Lord-Dufour, S.; Copland, I.B.; Levros, L.C.; Post, M.; Das, A.; Khosla, C.; Galipeau, J.; Rassart, E.; Annabi, B.
Evidence for transcriptional regulation of the glucose-6-phosphate transporter by HIF-1alpha: Targeting G6PT with mumbaistatin analogs in hypoxic mesenchymal stromal cells
Stem Cells
27
489-497
2009
Mus musculus
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