Information on EC 3.1.3.9 - glucose-6-phosphatase

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The expected taxonomic range for this enzyme is: Eukaryota

EC NUMBER
COMMENTARY hide
3.1.3.9
-
RECOMMENDED NAME
GeneOntology No.
glucose-6-phosphatase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-glucose 6-phosphate + H2O = D-glucose + phosphate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Galactose metabolism
-
-
gluconeogenesis III
-
-
Glycolysis / Gluconeogenesis
-
-
Metabolic pathways
-
-
Starch and sucrose metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
D-glucose-6-phosphate phosphohydrolase
Wide distribution in animal tissues. Also catalyses potent transphosphorylations from carbamoyl phosphate, hexose phosphates, diphosphate, phosphoenolpyruvate and nucleoside di- and triphosphates, to D-glucose, D-mannose, 3-methyl-D-glucose or 2-deoxy-D-glucose [cf. EC 2.7.1.62 (phosphoramidate---hexose phosphotransferase), EC 2.7.1.79 (diphosphate---glycerol phosphotransferase) and EC 3.9.1.1 (phosphoamidase)].
CAS REGISTRY NUMBER
COMMENTARY hide
9001-39-2
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
European sea bass
-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
Frog
-
-
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Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
Marmota sp.
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-
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Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
Pachnoda ephippiata
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
Phryganea sp.
-
-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
salamander
-
-
-
Manually annotated by BRENDA team
Sarcophaga barbata
-
-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
Turtle
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Manually annotated by BRENDA team
Vespa vulgaris
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
i.e. toad
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
-
an enhanced glucose 6-phosphatase activity in liver of rats exposed to Mg2+-deficient diet is detected
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-deoxy-2-fluoro-D-glucose 6-phosphate + H2O
2-deoxy-2-fluoro-D-glucose + phosphate
show the reaction diagram
-
18F-labeled model substrate
-
-
ir
2-deoxy-2-fluoro-D-glucose-6-phosphate + H2O
2-deoxy-2-fluoro-D-glucose + phosphate
show the reaction diagram
-
-
-
-
?
2-deoxy-D-glucose + diphosphate
?
show the reaction diagram
-
-
-
-
?
2-Deoxy-D-glucose 6-phosphate + H2O
2-Deoxy-D-glucose + phosphate
show the reaction diagram
5'-AMP + H2O
?
show the reaction diagram
-
2.6% of the activity with D-glucose 6-phosphate
-
-
?
beta-glycerophosphate + H2O
glycerol + phosphate
show the reaction diagram
-
1.2% of the activity with D-glucose 6-phosphate
-
-
?
carbamoyl-phosphate + glucose
glucose 6-phosphate + NH3 + CO2
show the reaction diagram
carbamoyl-phosphate + H2O
phosphate + NH3 + CO2
show the reaction diagram
-
-
-
?
D-galactose + diphosphate
?
show the reaction diagram
-
-
-
-
?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
show the reaction diagram
D-mannose + diphosphate
?
show the reaction diagram
-
-
-
-
?
D-mannose 6-phosphate + H2O
D-mannose + phosphate
show the reaction diagram
-
-
-
?
diphosphate + glucose
glucose 6-phosphate + phosphate
show the reaction diagram
diphosphate + H2O
2 phosphate
show the reaction diagram
glucose + ADP
glucose 6-phosphate + AMP
show the reaction diagram
-
-
-
-
?
glucose + ATP
glucose 6-phosphate + ADP
show the reaction diagram
-
-
-
-
?
glucose + CDP
glucose 6-phosphate + CMP
show the reaction diagram
-
-
-
-
?
glucose + CTP
glucose 6-phosphate + CDP
show the reaction diagram
-
-
-
-
?
glucose + dCTP
glucose 6-phosphate + dCDP
show the reaction diagram
-
-
-
-
?
glucose + GDP
glucose 6-phosphate + GMP
show the reaction diagram
-
-
-
-
?
glucose + GTP
glucose 6-phosphate + GDP
show the reaction diagram
-
-
-
-
?
glucose + ITP
glucose 6-phosphate + IDP
show the reaction diagram
glucose + phosphoenolpyruvate
glucose 6-phosphate + pyruvate
show the reaction diagram
-
-
-
-
?
glucose + phosphoramide
glucose + aminophosphate
show the reaction diagram
-
-
-
-
?
glycerol + diphosphate
?
show the reaction diagram
-
-
-
-
?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
show the reaction diagram
p-nitrophenylphosphate + H2O
p-nitrophenol + phosphate
show the reaction diagram
-
1.4% of the activity with D-glucose 6-phosphate
-
-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-glucose 6-phosphate + H2O
D-glucose + phosphate
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Cd2+
-
G6Pase is not a target of Cd2+ insult, the G6Pase activity measured at 37C is high only in 1-month Cd2+-treated group (0.84mg/kg, 35% increase of activity), in 1-week Cd2+-treated group measurements of G6Pase activity at 25C show marginal increase
Hg2+
-
exposure of newborn rats to mercury increases the hepatic alanine aminotransferase activity by fold and glucose 6-phosphatase activity by 75%. Zinc pre-exposure prevents totally and partially these mercury alterations, respectively. In vitro, HgCl2 inhibits the serum and liver alanine aminotransferase by 22% and 54%, respectively, serum and liver lactate dehydrogenase by 53% and 64%, respectively, and liver and kidney glucose 6-phosphatase from 10- to 13-day-old rats by 53% and 41%, respectively
Mg2+
-
reaction carried out in the absence or presence of 1 mM MgCl2
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-penten-3-one
-
-
1-propyl-3-(pyridyn-2-yl)thiourea
-
40.71% inhibition
-
1-[(4'-O-(E)-p-coumaroyl)-beta-D-glucopyranosyl]-oxy-2-phenol
-
-
1-[(6'-O-(E)-p-coumaroyl)-beta-D-glucopyranosyl]-oxy-2-phenol
-
-
1-[O-beta-D-glucopyranosyl(1->2)-beta-D-glucopyranosyl]-oxy-2-phenol
-
-
2-oxoglutarate
-
in complex with Mg2+, inhibition at low substrate concentrations, inhibition of the translocase component of the glucose 6-phosphatase system
2-{[bis(hydrazine)methylene]amino}-4-methylpentanoic acid
-
2.61% inhibition
-
2-{[bis(hydrazino)methylene]amino}-3-(4-hydroxyphenyl)propanoic acid
-
6.61% inhibition
-
2-{[bis(hydrazino)methylene]amino}-3-hydroxybutanoic acid
-
11.68% inhibition
-
2-{[bis(hydrazino)methylene]amino}-3-hydroxypropanoic acid
-
10.56% inhibition
-
2-{[bis(hydrazino)methylene]amino}-3-methylpentanoic acid
-
3.37% inhibition
-
3,4-dicaffeoylquinic acid
-
-
3,4-dichlorobenzaldehyde dibenzylhydrazone
-
-
3-Mercaptopicolinic acid
-
inhibitor of D-glucose 6-phosphate translocase
3-methoxybenzaldehyde dibenzylhydrazone
-
-
4,4'-di-isothiocyanostilbene-2,2'-disulphonate
-
inhibitor of D-glucose 6-phosphate translocase
4,5-dicaffeoylquinic acid
-
-
4-(beta-D-glucopyranosyloxy) benzoic acid
-
-
4-caffeoylquinic acid
-
-
4-chlorobenzaldehyde dibenzylhydrazone
-
-
4-hydroxybenzaldehyde dibenzylhydrazone
-
-
4-maleimidylstilbene-2,2'-disulfonic acid
-
-
4-methoxybenzaldehyde dibenzylhydrazone
-
-
4-methoxyphenyl-[4-(4-methoxyphenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl]methanone
4-methoxyphenyl-[4-(4-trifluoromethoxyphenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl]methanone
5-((((iodoacetyl)amino)ethyl)amino)naphtalene-1-sulfonic acid
-
-
-
5-caffeoylquinic acid
-
-
5-chlorotetrahydrothiophene-2-carbaldehyde dibenzylhydrazone
-
-
5-ethyltetrahydrofuran-2-carbaldehyde dibenzylhydrazone
-
-
alpha-phosphatidylinositol 3-monophosphate
-
-
alpha-phosphatidylinositol 4,5-diphosphate
-
-
alpha-phosphatidylinositol 4-monophosphate
-
-
amiloride
-
-
apigenin
-
-
apigenin-7-O-beta-D-glucopyranoside
-
-
apigenin-7-O-beta-D-glucuronic acid-6''-methyl ester
-
-
Arachidonoyl-CoA
-
-
behenoyl-CoA
-
-
benzaldehyde dibenzylhydrazone
-
-
chlorogenic acid
CoA
-
inhibits enzyme activity in intact microsomes
D-glucose
diphosphate
-
-
EGTA
-
inhibits enzyme activity in histone 2A-treated or alamethicin-treated microsomes, but has little effect on enzyme activity in intact microsomes
Epicatechin gallate
-
acts similarly but less efficiently than epigallocatechin gallate
epigallocatechin gallate
-
increases latency of G6Pase, inhibitory effect is greater in intact than in permeabilized microsomes. It does not hinder microsomal D-glucose 6-phosphate uptake. Reduces activity of G6Pase through the inhibition of glucose efflux from the endoplasmic reticulum lumen; inhibition of enzyme in intact, but not in permeabilized microsome. Epigallocatechin gallate does not hinder microsomal glucose uptake, but inhibits microsomal glucose efflux thus inhibiting the enzyme through an elevated luminal glucose level
fatty-acyl-CoA
-
with chain-length equal to or higher than 16, at 0.001-0.002 mM, the inhibitory effect on the enzyme of untreated microsomes is either partially or totally cancelled, or even changes into an activation effect at higher concentrations, the inhibition is fully reversible in presence of bovine serum albumin. With medium chain-length, 10-14 carbons inhibit the enzyme of untreated microsomes in a dose-dependent manner in the range 0.001-0.02 mM, the higher the chain length, the stronger the inhibitory effect
gallocatechin gallate
-
increases latency of G6Pase, inhibitory effect is greater in intact than in permeabilized microsomes
heptenal
-
-
Insulin
-
insulin causes a decrease in the activity of enzyme in the liver in vivo
-
isonicotinaldehyde dibenzylhydrazone
-
-
itoside H
-
-
kodaistatin A
-
A and C
L-alpha-phosphatidylinositol 3,4,5-trisphosphate
-
-
L-alpha-phosphatidylinositol 3,4-diphosphate
-
-
molybdate
mumbaistatin
-
-
myristoyl-CoA
-
uncompetitive inhibition of enzyme in untreated microsomes, non-competitive inhibition of enzyme from detergent-treated microsomes
N-(pyridine-2-yl)morpholine-4-carbothioamide
-
35.32% inhibition
-
N-(pyridine-2-yl)piperidine-4-carbothioamide
-
38.88% inhibition
-
nicotinaldehyde dibenzylhydrazone
-
-
nitrothiocyanobenzoic acid
-
-
-
oleoyl-CoA
-
-
orthovanadate
-
-
oxaloacetate
-
in complex with Mg2+, inhibition at low substrate concentrations, inhibition of the translocase component of the glucose 6-phosphatase system
p-hydroxy mercury-phenylsulfonate
-
-
p-hydroxy mercurybenzoic acid
-
-
palmitoyl-CoA
-
inhibits enzyme activity in intact microsomes
Pentamidine
-
-
pentenal
-
-
pentenone
-
-
-
Phenobarbital
-
the inhibition in dependence on the age of rats is studied
phosphate
phosphatidylinositol
-
-
phosphoinositides
-
in order of decreasing efficiency: phosphatidylinositol, L-alpha-phosphatidylinositol 3,4,5-trisphosphate, L-alpha-phosphatidylinositol 3,4-diphosphate, alpha-phosphatidylinositol 4,5-diphosphate, alpha-phosphatidylinositol 3-monophosphate, alpha-phosphatidylinositol 4-monophosphate, phosphatidylinositol. Mechanism of inhibition with alpha-phosphatidylinositol 3,4-diphosphate, alpha-phosphatidylinositol 4,5-diphosphate or L-alpha-phosphatidylinositol 3,4,5-trisphosphate is competitive
-
pyridine-2-carbaldehyde dibenzylhydrazone
-
-
pyrocatechol-O-beta-D-glucopyranoside
-
-
quercetin-3-O-beta-D-glucopyranoside
-
-
S5627
-
potent linear competitive inhibitor of the translocase component of the multicomponent hepatic glucose 6-phosphatase system
-
silibinin
-
induces a dose-dependent inhibition of gluconeogenesis associated with a potent decrease in enzyme activity; inhibits gluconeogenesis and D-glucose 6-phosphate hydrolysis from either lactate/pyruvate, glycerol or fructose in a dose-dependent manner. Effect is stronger in intact than in permeabilized microsomes
sodium barbital
-
3 mM, complete inhibition
sodium pentobarbital
-
3 mM, complete inhibition
stearoyl-CoA
-
-
Svetol
-
commercial unroasted and decaffeinated green Coffea canephora extract, competive inhibition
-
tetrahydrofuran-2-carbaldehyde dibenzylhydrazone
-
-
tetrahydrothiophene-2-carbaldehyde dibenzylhydrazone
-
-
tosyl-L-Lys-chloromethyl ketone
-
inactivation of the enzyme in intact microsomes, no effect on enzyme in deoxycholate-modified microsomes
tosyl-L-Phe-chloromethyl ketone
-
inactivation of the enzyme in intact microsomes, no effect on enzyme in deoxycholate-modified microsomes
tosyl-lysyl-chloromethane
-
inhibitor of D-glucose 6-phosphate translocase
tosylphenylalanylchloromethane
-
inhibitor of D-glucose 6-phosphate translocase
trans-2-nonenal
-
-
trans-2-pentenal
-
-
tungstate
-
-
vanadate
vanadyl acetylacetonate
-
mixed-type inhibition
-
vanadyl sulfate
-
37% inhibition at 0.048 microM, competitive inhibition
-
additional information
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
alamethicin
-
-
beta-naphthoflavone
-
the activation in dependence on the age of rats is studied
calyculin A
-
activation of enzyme in supernatant and in intact or disrupted microsomes
D-glucose
deoxycholate
-
-
dexamethasone
glycocorticoids
-
injection of glycocorticoids in vivo increases to a modestextent the activity of enzyme in the livers of control and adrenalectomized rats
-
Histone 2A
-
stimulates enzyme activity by permeabilizing the microsomal membrane
-
Lubrol
-
-
-
microcystin-LR
-
activation of enzyme in supernatant and in intact or disrupted microsomes
microcystin-RR
-
activation of enzyme in supernatant and in intact or disrupted microsomes
okadaic acid
-
activation of enzyme in supernatant and in intact or disrupted microsomes
additional information
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
11.1
ADP
-
partially purified enzyme
4.7
ATP
-
microsomal enzyme suspension
0.6 - 2.5
Carbamoyl phosphate
3.8
CDP
-
microsomal enzyme suspension
3.1
CTP
-
microsomal enzyme suspension
0.1 - 5.3
D-glucose 6-phosphate
2.6
dCTP
-
microsomal enzyme suspension
1.3 - 1.8
diphosphate
2.7
GDP
-
partially purified enzyme
0.51 - 2.7
glucose 6-phosphate
3.6
GTP
-
microsomal enzyme suspension
6.1
ITP
-
microsomal enzyme suspension
6.9
phosphoenolpyruvate
-
microsomal enzyme suspension
2.8
phosphoramide
-
microsomal enzyme suspension
additional information
additional information
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
700
glucose 6-phosphate
Rattus norvegicus
-
enzyme in disrupted microsomes
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00128
3,4-dichlorobenzaldehyde dibenzylhydrazone
-
-
0.00045
3-methoxybenzaldehyde dibenzylhydrazone
-
-
0.035
4,4'-di-isothiocyanostilbene-2,2'-disulphonate
-
-
0.00015
4-chlorobenzaldehyde dibenzylhydrazone
-
-
0.00154
4-hydroxybenzaldehyde dibenzylhydrazone
-
-
0.5
4-maleimidylstilbene-2,2'-disulfonic acid
-
-
0.00014
4-methoxybenzaldehyde dibenzylhydrazone
-
-
0.00027 - 0.0033
4-methoxyphenyl-[4-(4-methoxyphenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl]methanone
0.00029 - 0.004
4-methoxyphenyl-[4-(4-trifluoromethoxyphenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl]methanone
0.8
5-((((iodoacetyl)amino)ethyl)amino)naphtalene-1-sulfonic acid
-
-
-
0.00011
5-chlorotetrahydrothiophene-2-carbaldehyde dibenzylhydrazone
-
-
0.021
5-ethyltetrahydrofuran-2-carbaldehyde dibenzylhydrazone
-
-
0.00096
benzaldehyde dibenzylhydrazone
-
-
0.5
chlorogenic acid
-
-
50 - 200
D-glucose
-
-
0.6
DTNB
-
-
0.011
isonicotinaldehyde dibenzylhydrazone
-
-
0.237
nicotinaldehyde dibenzylhydrazone
-
-
2
nitrothiocyanobenzoic acid
-
-
-
0.0064
pyridine-2-carbaldehyde dibenzylhydrazone
-
-
0.000704
tetrahydrofuran-2-carbaldehyde dibenzylhydrazone
-
-
0.00096
tetrahydrothiophene-2-carbaldehyde dibenzylhydrazone
-
-
0.001 - 0.025
tungstate
0.0022 - 0.0056
vanadate
additional information
additional information
-
-
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0885
1-[(4'-O-(E)-p-coumaroyl)-beta-D-glucopyranosyl]-oxy-2-phenol
Rattus norvegicus
-
63.7% inhibition at 0.1 mM
0.081
1-[(6'-O-(E)-p-coumaroyl)-beta-D-glucopyranosyl]-oxy-2-phenol
Rattus norvegicus
-
66.9% inhibition at 0.1 mM
0.093
chlorogenic acid
Rattus norvegicus
-
69.6% inhibition at 0.1 mM
0.05
itoside H
Rattus norvegicus
-
85.4% inhibition at 0.1 mM
0.0935
orthovanadate
Rattus norvegicus
-
53.4% inhibition at 0.1 mM
0.095
pyrocatechol-O-beta-D-glucopyranoside
Rattus norvegicus
-
51.8% inhibition at 0.1 mM
0.051
quercetin-3-O-beta-D-glucopyranoside
Rattus norvegicus
-
82.9% inhibition at 0.1 mM
0.091
rutin
Rattus norvegicus
-
56.1% inhibition at 0.1 mM
0.2
vanadyl acetylacetonate
Bos taurus
-
pH 6.5, temperature not specified in the publication
-
additional information
1-[O-beta-D-glucopyranosyl(1->2)-beta-D-glucopyranosyl]-oxy-2-phenol
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0078
purified FLAG-tagged recombinant mutant T16R
0.008
purified detagged recombinant mutant T16R
0.0083
purified detagged or FLAG-tagged recombinant mutant Y209C
0.011
-
brain
0.021 - 0.066
-
activity in hepatocellular carcinoma
0.047
-
arthritic rats
0.051
-
enzyme from liver
0.068
purified FLAG-tagged recombinant wild-type enzyme
0.102
-
activity using pSVL expression system
0.114 - 0.239
-
activity in healthy normal liver
0.136
purified detagged recombinant wild-type enzyme
0.272
-
liver
0.335
-
enzyme from microsomes, at 25C
0.5473
-
enzyme from octylglucoside-solubilized extract, at 25C
1.065
-
enzyme from proteoliposomes dialyzed against MOPS buffer, at 25C
1.268
-
activity using adenoviral expression system
6.58
-
enzyme from placenta
47.5
-
intact microsome, presence of 0.1 mM epigallocatechin gallate
67.7
recombinant FLAG-tagged wild-type enzyme
80
-
intact microsome
107
-
permeabilized microsome, presence of 0.1 mM epigallocatechin gallate
124
-
permeabilized microsome
136
recombinant non-tagged wild-type enzyme
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.5 - 6
-
-
5.5
-
enzyme from testis
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
two enzyme forms: an acid-sensitive Glc-6-Pase-alpha in liver, kidney and intestine, and an acid-insensitive Glc-6-Pase-beta in astroctyes
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
assay at
additional information
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
liver cell
Manually annotated by BRENDA team
-
red portion and white portion
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
activity of glucose-6-phosphatase in crude cytosol is positively correlated with the amount of secreted multipolypeptide complex called counting factor
Manually annotated by BRENDA team