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Disease on EC 3.1.3.86 - phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Murine pancreatic adenocarcinoma dampens SHIP-1 expression and alters MDSC homeostasis and function.
Alzheimer Disease
Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population.
Combining data integration and molecular dynamics for target identification in ?-Synuclein-aggregating neurodegenerative diseases: Structural insights on Synaptojanin-1 (Synj1).
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline.
Hydrogen sulfide and mesenchymal stem cells-extracted microvesicles attenuate LPS-induced Alzheimer's disease.
INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia.
INPP5D mRNA Expression and Cognitive Decline in Japanese Alzheimer's Disease Subjects.
INPP5D rs35349669 polymorphism with late-onset Alzheimer's disease: A replication study and meta-analysis.
Amyloidosis
Associations of Alzheimer's disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegeneration.
Arthritis, Gouty
MicroRNA-155 as a proinflammatory regulator via SHIP-1 down-regulation in acute gouty arthritis.
Asthma
Src homology 2 domain-containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lung.
Autoimmune Diseases
SHIP-1 deficiency in the myeloid compartment is insufficient to induce myeloid expansion or chronic inflammation.
Bone Resorption
Src homology 2 (SH2)-containing 5'-inositol phosphatase localizes to podosomes, and the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts.
Brain Neoplasms
Glioma and Alzheimer's Disease.
Candidiasis
Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection.
Carcinoma
MicroRNA-155 governs SHIP-1 expression and localization in NK cells and regulates subsequent infiltration into murine AT3 mammary carcinoma.
Cataract
Molecular characterization of the human lens epithelium-derived cell line SRA01/04.
Chronic Urticaria
Cultured peripheral blood mast cells from chronic idiopathic urticaria patients spontaneously degranulate upon IgE sensitization: Relationship to expression of Syk and SHIP-2.
Colitis
IL-10/microRNA-155/SHIP-1 signaling pathway is crucial for commensal bacteria induced spontaneous colitis.
MicroRNA-155 promotes the pathogenesis of experimental colitis by repressing SHIP-1 expression.
Colorectal Neoplasms
Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation.
Cystitis, Interstitial
Lower Urinary Tract Symptoms: What's New in Medical Treatment?
Diabetes Mellitus, Type 1
A Precision B Cell-Targeted Therapeutic Approach to Autoimmunity Caused by Phosphatidylinositol 3-Kinase Pathway Dysregulation.
INPPL1 is associated with the metabolic syndrome in men with Type 1 diabetes, but not with diabetic nephropathy.
Diabetes Mellitus, Type 2
A high-throughput microfluidic assay for SH2 domain-containing inositol 5-phosphatase 2.
Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome.
Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2).
The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man.
Diabetic Nephropathies
INPPL1 is associated with the metabolic syndrome in men with Type 1 diabetes, but not with diabetic nephropathy.
Diverticulitis
RNA-seq implicates deregulation of the immune system in the pathogenesis of diverticulitis.
Encephalitis, Japanese
MicroRNA 155 Regulates Japanese Encephalitis Virus-Induced Inflammatory Response by Targeting Src Homology 2-Containing Inositol Phosphatase 1.
Essential Hypertension
Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension.
Glioblastoma
5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells.
Hematologic Neoplasms
A novel strategy for modulation of MDSC to enhance cancer immunotherapy.
Hypersensitivity
Gene transfer of SHIP-1 inhibits proliferation of juvenile myelomonocytic leukemia cells carrying KRAS2 or PTPN11 mutations.
Hypertension
Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension.
Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome.
Ileitis
SHIP-1 deficiency in the myeloid compartment is insufficient to induce myeloid expansion or chronic inflammation.
Infections
Low perforin and elevated SHIP-1 expression is associated with functional anergy of natural killer cells in chronic HIV-1 infection.
MicroRNA 155 Regulates Japanese Encephalitis Virus-Induced Inflammatory Response by Targeting Src Homology 2-Containing Inositol Phosphatase 1.
Porcine Fc?RIIb mediated PRRSV ADE infection through inhibiting IFN-? by cytoplasmic inhibitory signal transduction.
SHIP-1 Regulates Phagocytosis and M2 Polarization Through the PI3K/Akt-STAT5-Trib1 Circuit in Pseudomonas aeruginosa Infection.
Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection.
The phosphatidylinositol 5-phosphatase oculocerebrorenal syndrome of Lowe protein (OCRL) controls actin dynamics during early steps of Listeria monocytogenes infection.
Influenza, Human
Distinct macrophage subpopulations characterize acute infection and chronic inflammatory lung disease.
Insulin Resistance
Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity.
Association of SH2-containing inositol phosphatase 2 with the insulin resistance of diabetic db/db mice.
Impact of SRC homology 2-containing inositol 5'-phosphatase 2 gene polymorphisms detected in a Japanese population on insulin signaling.
INPPL1 is associated with the metabolic syndrome in men with Type 1 diabetes, but not with diabetic nephropathy.
Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome.
SH2 domain-containing inositol 5-phosphatase (SHIP2) inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK/mTOR/SREBP1 pathway and ROS production in HepG2 cells.
Leukemia
Gene transfer of SHIP-1 inhibits proliferation of juvenile myelomonocytic leukemia cells carrying KRAS2 or PTPN11 mutations.
LNK/SH2B3 Loss of Function Promotes Atherosclerosis and Thrombosis.
The inositol 5'-phosphatase SHIP-2 negatively regulates IgE-induced mast cell degranulation and cytokine production.
[Effect of SHIP-1 on Invasion, Migration and PI3K-AKT Signaling Pathway of Leukemic Cells].
Leukemia, Erythroblastic, Acute
The inositol phosphatase SHIP-1 is negatively regulated by Fli-1 and its loss accelerates leukemogenesis.
Leukemia, Lymphocytic, Chronic, B-Cell
Overexpression of SH2-Containing Inositol Phosphatase Contributes to Chronic Lymphocytic Leukemia Survival.
Leukemia, Myeloid, Acute
Reduced proliferation of CD34(+) cells from patients with acute myeloid leukemia after gene transfer of INPP5D.
Leukemia, Myelomonocytic, Juvenile
Gene transfer of SHIP-1 inhibits proliferation of juvenile myelomonocytic leukemia cells carrying KRAS2 or PTPN11 mutations.
Leukemia-Lymphoma, Adult T-Cell
Alteration of phosphatidylinositol 3-kinase cascade in the multilobulated nuclear formation of adult T cell leukemia/lymphoma (ATLL).
Human T-cell leukemia virus type I tax down-regulates the expression of phosphatidylinositol 3,4,5-trisphosphate inositol phosphatases via the NF-kappaB pathway.
Lung Diseases
Distinct macrophage subpopulations characterize acute infection and chronic inflammatory lung disease.
Genetic segregation of inflammatory lung disease and autoimmune disease severity in SHIP-1-/- mice.
SHIP-1 deficiency in the myeloid compartment is insufficient to induce myeloid expansion or chronic inflammation.
Lupus Erythematosus, Systemic
A Precision B Cell-Targeted Therapeutic Approach to Autoimmunity Caused by Phosphatidylinositol 3-Kinase Pathway Dysregulation.
Lymphatic Diseases
Evidence for SH2 domain-containing 5'-inositol phosphatase-2 (SHIP2) contributing to a lymphatic dysfunction.
Lymphatic Metastasis
Underexpression of INPPL1 is associated with aggressive clinicopathologic characteristics in papillary thyroid carcinoma.
Lymphoma
Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma.
B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells.
Phosphoinositide phosphatase SHIP-1 regulates apoptosis induced by edelfosine, Fas ligation and DNA damage in mouse lymphoma cells.
Quantification of change in phosphorylation of BCR-ABL kinase and its substrates in response to Imatinib treatment in human chronic myelogenous leukemia cells.
Lymphoma, B-Cell
SHIP-1 inhibits CD95/APO-1/Fas-induced apoptosis in primary T lymphocytes and T leukemic cells by promoting CD95 glycosylation independently of its phosphatase activity.
Melanoma
Transcriptomic identification of miR-205 target genes potentially involved in metastasis and survival of cutaneous malignant melanoma.
Metabolic Syndrome
Can Alzheimer disease be a form of type 3 diabetes?
Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension.
INPPL1 is associated with the metabolic syndrome in men with Type 1 diabetes, but not with diabetic nephropathy.
Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome.
Multiple Myeloma
Immune cell inhibition by SLAMF7 is mediated by a mechanism requiring src kinases, CD45, and SHIP-1 that is defective in multiple myeloma cells.
Myelodysplastic Syndromes
Loss of SHIP-1 protein expression in high-risk myelodysplastic syndromes is associated with miR-210 and miR-155.
Myeloproliferative Disorders
The duplicitous nature of the Lyn tyrosine kinase in growth factor signaling.
Neoplasm Metastasis
Underexpression of INPPL1 is associated with aggressive clinicopathologic characteristics in papillary thyroid carcinoma.
Neoplasms
5'-Inositol phosphatase SHIP2 recruits Mena to stabilize invadopodia for cancer cell invasion.
A novel strategy for modulation of MDSC to enhance cancer immunotherapy.
Alteration of phosphatidylinositol 3-kinase cascade in the multilobulated nuclear formation of adult T cell leukemia/lymphoma (ATLL).
Apigenin Increases SHIP-1 Expression, Promotes Tumoricidal Macrophages and Anti-Tumor Immune Responses in Murine Pancreatic Cancer.
BCL9L expression in pancreatic neoplasia with a focus on SPN: a possible explanation for the enigma of the benign neoplasia.
Effects of SHIP-1 on MMP2 secretion and invasion of SR3Y1 cells.
Enzymatic and non-enzymatic activities of SHIP-1 in signal transduction and cancer.
Histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)-induced histamine release is enhanced with SHIP-1 knockdown in cultured human mast cell and basophil models.
Human T-cell leukemia virus type I tax down-regulates the expression of phosphatidylinositol 3,4,5-trisphosphate inositol phosphatases via the NF-kappaB pathway.
INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor.
MicroRNA-155 governs SHIP-1 expression and localization in NK cells and regulates subsequent infiltration into murine AT3 mammary carcinoma.
Murine pancreatic adenocarcinoma dampens SHIP-1 expression and alters MDSC homeostasis and function.
Regulation of hematopoietic cell signaling by SHIP-1 inositol phosphatase: growth factors and beyond.
The duplicitous nature of the Lyn tyrosine kinase in growth factor signaling.
Transcriptome profiling in oral cavity and esophagus tissues from (S)-N'-nitrosonornicotine-treated rats reveals candidate genes involved in human oral cavity and esophageal carcinogenesis.
Underexpression of INPPL1 is associated with aggressive clinicopathologic characteristics in papillary thyroid carcinoma.
Obesity
Genome-wide association study for backfat thickness at 100 kg and loin muscle thickness in domestic pigs based on genotyping by sequencing.
Phosphoinositol phosphatase SHIP2 promotes cancer development and metastasis coupled with alterations in EGF receptor turnover.
Obesity, Abdominal
Association between waist circumference and gray matter volume in 2344 individuals from two adult community-based samples.
Oculocerebrorenal Syndrome
Bleeding disorders in Lowe syndrome patients: evidence for a link between OCRL mutations and primary haemostasis disorders.
The impact of phosphoinositide 5-phosphatases on phosphoinositides in cell function and human disease.
The phosphatidylinositol 5-phosphatase oculocerebrorenal syndrome of Lowe protein (OCRL) controls actin dynamics during early steps of Listeria monocytogenes infection.
Osteoarthritis
MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis.
Pancreatic Neoplasms
Apigenin Increases SHIP-1 Expression, Promotes Tumoricidal Macrophages and Anti-Tumor Immune Responses in Murine Pancreatic Cancer.
Murine pancreatic adenocarcinoma dampens SHIP-1 expression and alters MDSC homeostasis and function.
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase deficiency
Distinct macrophage subpopulations characterize acute infection and chronic inflammatory lung disease.
Lipid phosphatase SHIP-1 regulates chondrocyte hypertrophy and skeletal development.
SHIP-1 Deficiency in AID
SHIP-1 deficiency in the myeloid compartment is insufficient to induce myeloid expansion or chronic inflammation.
SHIP-1 increases early oxidative burst and regulates phagosome maturation in macrophages.
SHIP-1 inhibits CD95/APO-1/Fas-induced apoptosis in primary T lymphocytes and T leukemic cells by promoting CD95 glycosylation independently of its phosphatase activity.
SHIP-1 Regulates Phagocytosis and M2 Polarization Through the PI3K/Akt-STAT5-Trib1 Circuit in Pseudomonas aeruginosa Infection.
phosphoinositide 5-phosphatase deficiency
SHIP1 Deficiency in Inflammatory Bowel Disease Is Associated With Severe Crohn's Disease and Peripheral T Cell Reduction.
Pneumonia
Genetic segregation of inflammatory lung disease and autoimmune disease severity in SHIP-1-/- mice.
Selective deletion of SHIP-1 in hematopoietic cells in mice leads to severe lung inflammation involving ILC2 cells.
SHIP-1 deficiency in the myeloid compartment is insufficient to induce myeloid expansion or chronic inflammation.
SHIP-1, a target of miR-155, regulates endothelial cell responses in lung fibrosis.
Pseudomonas Infections
SHIP-1 Regulates Phagocytosis and M2 Polarization Through the PI3K/Akt-STAT5-Trib1 Circuit in Pseudomonas aeruginosa Infection.
Pulmonary Disease, Chronic Obstructive
SHIP-1 deficiency in the myeloid compartment is insufficient to induce myeloid expansion or chronic inflammation.
Sepsis
SHIP-1 Regulates Phagocytosis and M2 Polarization Through the PI3K/Akt-STAT5-Trib1 Circuit in Pseudomonas aeruginosa Infection.
Stroke
Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1: a meaningful and independent marker to predict stroke in the chinese population.
RNA in blood is altered prior to hemorrhagic transformation in ischemic stroke.
Tauopathies
Associations of Alzheimer's disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegeneration.
Thyroid Cancer, Papillary
Underexpression of INPPL1 is associated with aggressive clinicopathologic characteristics in papillary thyroid carcinoma.
Thyroid Diseases
Diagnosed thyroid disorders are associated with depression and anxiety.
Urticaria
Cultured peripheral blood mast cells from chronic idiopathic urticaria patients spontaneously degranulate upon IgE sensitization: Relationship to expression of Syk and SHIP-2.
Vaccinia
SH2-containing inositol phosphatase (SHIP-1) transiently translocates to raft domains and modulates CD16-mediated cytotoxicity in human NK cells.