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Information on EC 3.1.3.78 - phosphatidylinositol-4,5-bisphosphate 4-phosphatase and Organism(s) Salmonella typhimurium and UniProt Accession O30916

for references in articles please use BRENDA:EC3.1.3.78
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IUBMB Comments
Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2] . One is catalysed by this enzyme and the other by EC 3.1.3.36, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P . In humans, the enzyme is localized to late endosomal/lysosomal membranes . It can control nuclear levels of PtdIns5P and thereby control p53-dependent apoptosis .
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Salmonella typhimurium
UNIPROT: O30916
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
type i 4-phosphatase, type i phosphatidylinositol-4,5-bisphosphate 4-phosphatase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
PtdIns-4,5-P2 4-phosphatase type I
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PtdIns-4,5-P2 4-phosphatase type II
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase
Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2] [2]. One is catalysed by this enzyme and the other by EC 3.1.3.36, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P [2]. In humans, the enzyme is localized to late endosomal/lysosomal membranes [2]. It can control nuclear levels of PtdIns5P and thereby control p53-dependent apoptosis [3].