Any feedback?
Information on EC 3.1.3.7 - 3'(2'),5'-bisphosphate nucleotidase and Organism(s) Mus musculus and UniProt Accession Q9Z0S1
for references in articles please use BRENDA:EC3.1.3.7Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
3.1.3.7 3'(2'),5'-bisphosphate nucleotidaseIUBMB Comments
Also acts on 3'-phosphoadenylyl sulfate, and on the corresponding 2'-phosphates.
Specify your search results
Word Map
- 3.1.3.7
-
phosphatidic
-
1-phosphatase
-
3'2',5'-bisphosphate
- 5'-phosphosulfate
- 3'-phosphoadenosine-5'-phosphate
- exoribonuclease
-
lithium-sensitive
- medicine
- synthesis
- biotechnology
- pharmacology
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
papase, pap phosphatase, bpnt1, rv2837c, fiery1, met22, 3'(2'),5'-bisphosphate nucleotidase, gpapp, bpnt-1, bpntase, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase
-
-
-
-
3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase
-
-
-
-
3'-phosphoadenylylsulfate 3'-phosphatase
-
-
-
-
adenosine-3',5'-bisphosphate 3'-phosphohydrolase
-
-
-
-
DPNPase
-
-
-
-
Halotolerance protein tol1
-
-
-
-
nucleotidase, phosphoadenylate 3'-
-
-
-
-
phosphoadenylate 3'-nucleotidase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase
Also acts on 3'-phosphoadenylyl sulfate, and on the corresponding 2'-phosphates.
CAS REGISTRY NUMBER
COMMENTARY
9025-83-6
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
?
inositol 1,3,4-trisphosphate + H2O
inositol 3,4-bisphosphate + phosphate
-
-
?
inositol 1,4-bisphosphate + H2O
inositol 4-phosphate + phosphate
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
additional information
?
-
3'-phosphoadenosine 5'-phosphate 3'-phosphatase plays a role in the formation of skeletal elements derived through endochondral ossification
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
3'-phosphoadenosine 5'-phosphate 3'-phosphatase plays a role in the formation of skeletal elements derived through endochondral ossification
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
isoform Bpnt1 is most enriched in the enterocytes of the small intestine and the proximal tubule and thick ascending limb epithelia of the kidneys
isoform Bpnt1 is most enriched in the enterocytes of the small intestine and the proximal tubule and thick ascending limb epithelia of the kidneys
additional information
isoform Bpnt1 is expressed at relatively similar levels in a majority of tissues including the brain, heart, lungs, spleen, pancreas, stomach, liver, small intestine, colon, kidneys, and testes. Bpnt1 is most enriched in the enterocytes of the small intestine and the proximal tubule and thick ascending limb epithelia of the kidneys
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
physiological function
mice deficient for bisphosphate 3'-nucleotidase Bpnt1 do not exhibit skeletal defects but instead develop severe liver pathologies, including hypoproteinemia, hepatocellular damage, and in severe cases, frank whole body edema and death. These phenotypes are accompanied by tissue-specific elevations of the substrate 3'-phosphoadenosine 5'-phosphate, up to 50fold in liver, repressed translation, and aberrant nucleolar architecture. The phenotypes of the Bpnt1 knockout are rescued by generating a double mutant mouse deficient for both 3'-phosphoadenosine 5'-phosphate synthesis and hydrolysis, consistent with a mechanism in which 3'-phosphoadenosine 5'-phosphate accumulation is toxic to tissue function independent of sulfation
physiological function
while cytoplasmic bisphosphate nucleotidase Bpnt1 is widely expressed in a majority of tissues, in Bpnt1 knockout mice only the liver, duodenum, and kidneys show high levels of its substrate 3'-phosphoadenosine 5'-phosphate and nucleolar reorganization
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). BPNT1_MOUSE
308
0
33196
Swiss-Prot
Mitochondrion (Reliability: 5)
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
mice deficient for bisphosphate 3'-nucleotidase Bpnt1 do not exhibit skeletal defects but instead develop severe liver pathologies, including hypoproteinemia, hepatocellular damage, and in severe cases, frank whole body edema and death. These phenotypes are accompanied by tissue-specific elevations of the substrate 3?-phosphoadenosine 5'-phosphate, up to 50fold in liver, repressed translation, and aberrant nucleolar architecture. The phenotypes of the Bpnt1 knockout are rescued by generating a double mutant mouse deficient for both 3'-phosphoadenosine 5'-phosphate synthesis and hydrolysis, consistent with a mechanism in which 3'-phosphoadenosine 5'-phosphate accumulation is toxic to tissue function independent of sulfation
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Spiegelberg, B.D.; Xiong, J.P.; Smith, J.J.; Gu, R.F.; York, J.D.
Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3-nucleotidase inhibited by inositol 1,4-bisphosphate
J. Biol. Chem.
274
13619-13628
1999
Homo sapiens (O95861), Homo sapiens, Mus musculus (Q9Z0S1), Mus musculus
Frederick, J.P.; Tafari, A.T.; Wu, S.M.; Megosh, L.C.; Chiou, S.T.; Irving, R.P.; York, J.D.
A role for a lithium-inhibited Golgi nucleotidase in skeletal development and sulfation
Proc. Natl. Acad. Sci. USA
105
11605-11612
2008
Mus musculus (Q80V26)
Hudson, B.H.; York, J.D.
Tissue-specific regulation of 3-nucleotide hydrolysis and nucleolar architecture
Adv. Biol. Regul.
54
208-213
2014
Mus musculus (Q9Z0S1)
EXTERNAL LINKS (specific for EC-Number 3.1.3.7)
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
