Reference on EC 3.1.3.66 - phosphatidylinositol-3,4-bisphosphate 4-phosphatase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Howell, S.; Barnaby, R.J.; Rowe, T.; Ragan, C.I.; Gee, N.S.
Evidence for at least four different inositol bisphosphatases in bovine brain
Eur. J. Biochem.
183
169-172
1989
Bos taurus
Munday, A.D.; Norris, F.A.; Caldwell, K.K.; Brown, S.; Majerus, P.W.; Mitchell, C.A.
The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol
Proc. Natl. Acad. Sci. USA
96
3640-3645
1999
Homo sapiens
Norris, F.A.; Auethavekiat, V.; Majerus, P.W.
The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase
J. Biol. Chem.
270
16128-16133
1995
BRENDA: Rattus norvegicus (Q62784), Homo sapiens (Q96PE3), Homo sapiens
Textmining: Rattus
Norris, F.A.; Atkins, R.C.; Majerus, P.W.
The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family
J. Biol. Chem.
272
23859-23864
1997
Homo sapiens (Q96PE3), Homo sapiens, Rattus norvegicus (Q9QWG5)
Norris, F.A.; Atkins, R.C.; Majerus, P.W.
Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human platelets
J. Biol. Chem.
272
10987-10989
1997
Homo sapiens
Ivetac, I.; Munday, A.D.; Kisseleva, M.V.; Zhang, X.M.; Luff, S.; Tiganis, T.; Whisstock, J.C.; Rowe, T.; Majerus, P.W.; Mitchell, C.A.
The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane
Mol. Biol. Cell
16
2218-2233
2005
Homo sapiens
Sharma, M.; Batra, J.; Mabalirajan, U.; Sharma, S.; Nagarkatti, R.; Aich, J.; Sharma, S.K.; Niphadkar, P.V.; Ghosh, B.
A genetic variation in inositol polyphosphate 4 phosphatase A enhances susceptibility to asthma
Am. J. Respir. Crit. Care Med.
177
712-719
2008
BRENDA: Homo sapiens (Q96PE3), Homo sapiens
Textmining: Mus musculus, Mus sp.
Jeynov, B.; Lay, D.; Schmidt, F.; Tahirovic, S.; Just, W.W.
Phosphoinositide synthesis and degradation in isolated rat liver peroxisomes
FEBS Lett.
580
5917-5924
2006
Rattus norvegicus
Barnache, S.; Le Scolan, E.; Kosmider, O.; Denis, N.; Moreau-Gachelin, F.
Phosphatidylinositol 4-phosphatase type II is an erythropoietin-responsive gene
Oncogene
25
1420-1423
2006
Mus musculus
Thole, J.M.; Vermeer, J.E.; Zhang, Y.; Gadella, T.W.; Nielsen, E.
Root hair defective4 encodes a phosphatidylinositol-4-phosphate phosphatase required for proper root hair development in Arabidopsis thaliana
Plant Cell
20
381-395
2008
Arabidopsis thaliana (Q9C5G5), Arabidopsis thaliana
Gewinner, C.; Wang, Z.C.; Richardson, A.; Teruya-Feldstein, J.; Etemadmoghadam, D.; Bowtell, D.; Barretina, J.; Lin, W.M.; Rameh, L.; Salmena, L.; Pandolfi, P.P.; Cantley, L.C.
Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling
Cancer Cell
16
115-125
2009
BRENDA: Homo sapiens
Textmining: Transformation
Ivetac, I.; Gurung, R.; Hakim, S.; Horan, K.A.; Sheffield, D.A.; Binge, L.C.; Majerus, P.W.; Tiganis, T.; Mitchell, C.A.
Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1
EMBO Rep.
10
487-493
2009
BRENDA: Mus musculus
Textmining: Transformation
Sachs, A.; David, S.; Haider, N.; Nystuen, A.
Patterned neuroprotection in the Inpp4a(wbl) mutant mouse cerebellum correlates with the expression of Eaat4
PLoS ONE
4
e8270
2009
BRENDA: Mus musculus
Textmining: Homo sapiens
Marjanovic, J.; Wilson, M.; Zhang, C.; Zou, J.; Nicholas, P.; Majerus, P.
The role of inositol polyphosphate 4-phosphatase 1 in platelet function using a weeble mouse model
Adv. Enzyme Regul.
51
101-105
2011
Mus musculus
Hodgson, M.C.; Shao, L.J.; Frolov, A.; Li, R.; Peterson, L.E.; Ayala, G.; Ittmann, M.M.; Weigel, N.L.; Agoulnik, I.U.
Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer
Cancer Res.
71
572-582
2011
Homo sapiens
Fedele, C.G.; Ooms, L.M.; Ho, M.; Vieusseux, J.; OToole, S.A.; Millar, E.K.; Lopez-Knowles, E.; Sriratana, A.; Gurung, R.; Baglietto, L.; Giles, G.G.; Bailey, C.G.; Rasko, J.E.; Shields, B.J.; Price, J.T.; Majerus, P.W.; Sutherland, R.L.; Tiganis, T.; McLean, C.A.; Mitchell, C.A.
Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
Proc. Natl. Acad. Sci. USA
107
22231-22236
2010
Homo sapiens
Balakrishnan, A.; Chaillet, J.R.
Role of the inositol polyphosphate-4-phosphatase type II Inpp4b in the generation of ovarian teratomas
Dev. Biol.
373
118-129
2013
BRENDA: Mus musculus
Textmining: insertion sequences, Homo sapiens, Mus sp.
Aich, J.; Mabalirajan, U.; Ahmad, T.; Agrawal, A.; Ghosh, B.
Loss-of-function of inositol polyphosphate-4-phosphatase reversibly increases the severity of allergic airway inflammation
Nat. Commun.
3
877
2012
Mus musculus
Khanna, K.; Chaudhuri, R.; Aich, J.; Pattnaik, B.; Panda, L.; Prakash, Y.S.; Mabalirajan, U.; Ghosh, B.; Agrawal, A.
Secretory inositol polyphosphate 4-phosphatase protects against airway inflammation and remodeling
Am. J. Respir. Cell Mol. Biol.
60
399-412
2018
BRENDA: Homo sapiens (Q96PE3), Homo sapiens, Mus musculus (Q9EPW0)
Textmining: Mus sp.
Sung, J.Y.; Na, K.; Kim, H.S.
Down-regulation of inositol polyphosphate 4-phosphatase type II expression in colorectal carcinoma
Anticancer Res.
37
5525-5531
2017
Homo sapiens (O15327), Homo sapiens
Rijal, S.; Fleming, S.; Cummings, N.; Rynkiewicz, N.K.; Ooms, L.M.; Nguyen, N.Y.; Teh, T.C.; Avery, S.; McManus, J.F.; Papenfuss, A.T.; McLean, C.; Guthridge, M.A.; Mitchell, C.A.; Wei, A.H.
Inositol polyphosphate 4-phosphatase II (INPP4B) is associated with chemoresistance and poor outcome in AML
Blood
125
2815-2824
2015
Homo sapiens (O15327), Homo sapiens
Zhang, B.; Wang, W.; Li, C.; Liu, R.
Inositol polyphosphate-4-phosphatase type II plays critical roles in the modulation of cadherin-mediated adhesion dynamics of pancreatic ductal adenocarcinomas
Cell Adh. Migr.
12
548-563
2018
Homo sapiens (O15327), Homo sapiens
Morioka, S.; Nigorikawa, K.; Sasaki, J.; Hazeki, K.; Kasuu, Y.; Sasaki, T.; Hazeki, O.
Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model
Innate Immun.
22
444-451
2016
BRENDA: Mus musculus (Q9EPW0), Mus musculus
Textmining: Mus sp., Escherichia coli
Li, D.; Yang, J.; Ma, H.; Sun, C.; Feng, R.
Inositol polyphosphate-4-phosphatase type II and rucaparib treatment inhibit the growth of osteosarcoma cells dependent on phosphoinositide 3-kinase/protein kinase B pathway
J. Cell. Biochem.
119
9899-9909
2018
Homo sapiens (O15327), Homo sapiens
Li, H.; Wu, X.; Hou, S.; Malek, M.; Kielkowska, A.; Noh, E.; Makondo, K.J.; Du, Q.; Wilkins, J.A.; Johnston, J.B.; Gibson, S.B.; Lin, F.; Marshall, A.J.
Phosphatidylinositol-3,4-bisphosphate and its binding protein lamellipodin regulate chemotaxis of malignant B lymphocytes
J. Immunol.
196
586-595
2016
Homo sapiens (O15327)
Reed, D.E.; Shokat, K.M.
INPP4B and PTEN loss leads to PI-3,4-P2 accumulation and inhibition of PI3K in TNBC
Mol. Cancer Res.
15
765-775
2017
Homo sapiens (O15327), Homo sapiens
Zhang, M.; Suarez, E.; Vasquez, J.L.; Nathanson, L.; Peterson, L.E.; Rajapakshe, K.; Basil, P.; Weigel, N.L.; Coarfa, C.; Agoulnik, I.U.
Inositol polyphosphate 4-phosphatase type II regulation of androgen receptor activity
Oncogene
38
1121-1135
2018
Homo sapiens (O15327), Homo sapiens, Mus musculus (Q6P1Y8), Mus musculus
Nigorikawa, K.; Hazeki, K.; Sasaki, J.; Omori, Y.; Miyake, M.; Morioka, S.; Guo, Y.; Sasaki, T.; Hazeki, O.
Inositol polyphosphate-4-phosphatase type I negatively regulates phagocytosis via dephosphorylation of phagosomal PtdIns(3,4)P2
PLoS ONE
10
e0142091
2015
BRENDA: Mus musculus (Q9EPW0)
Textmining: Homo sapiens, Mus sp.
Chen, H.; Luo, Q.; Li, H.
MicroRNA-590-3p promotes cell proliferation and invasion by targeting inositol polyphosphate 4-phosphatase type II in human prostate cancer cells
Tumour Biol.
39
FEHLT
2017
Homo sapiens (O15327), Homo sapiens
Bertucci, MC; Mitchell, CA
Phosphoinositide 3-kinase and INPP4B in human breast cancer.
Ann N Y Acad Sci
1280
1-5
2013
Homo sapiens
Bonora, E; Bianco, F; Stanzani, A; Giancola, F; Astolfi, A; Indio, V; Evangelisti, C; Martelli, AM; Boschetti, E; Lugaresi, M; Ioannou, A; Torresan, F; Stanghellini, V; Clavenzani, P; Seri, M; Moonen, A; Van Beek, K; Wouters, M; Boeckxstaens, GE; Zaninotto, G; Mattioli, S; De Giorgio, R
INPP4B overexpression and c-KIT downregulation in human achalasia.
Neurogastroenterol Motil
30
e13346
2018
Homo sapiens
Yang, AW; Sachs, AJ; Nystuen, AM
Deletion of Inpp5a causes ataxia and cerebellar degeneration in mice.
Neurogenetics
16
277-85
2015
Mus musculus
Joseph, RE; Walker, J; Norris, FA
Assignment of the inositol polyphosphate 4-phosphatase type I gene (INPP4A) to human chromosome band 2q11.2 by in situ hybridization.
Cytogenet Cell Genet
87
276-7
1999
Homo sapiens
Shearn, CT; Walker, J; Norris, FA
Identification of a novel spliceoform of inositol polyphosphate 4-phosphatase type Ialpha expressed in human platelets: structure of human inositol polyphosphate 4-phosphatase type I gene.
Biochem Biophys Res Commun
286
119-25
2001
Homo sapiens
Nystuen, A; Legare, ME; Shultz, LD; Frankel, WN
A null mutation in inositol polyphosphate 4-phosphatase type I causes selective neuronal loss in weeble mutant mice.
Neuron
32
203-12
2001
Mus sp.
Ferron, M; Vacher, J
Characterization of the murine Inpp4b gene and identification of a novel isoform.
Gene
376
152-61
2006
Mus musculus, Homo sapiens, Rattus
Genini, S; Nguyen, TT; BĆ¼rgi, E; Stranzinger, G; Vƶgeli, P; Giuffra, E
Elimination of INPP4A and SLC5A7 as candidate genes for congenital progressive ataxia and spastic paresis in pigs.
Anim Genet
2009
Suidae
Ferron, M; Boudiffa, M; Arsenault, M; Rached, M; Pata, M; Giroux, S; Elfassihi, L; Kisseleva, M; Majerus, PW; Rousseau, F; Vacher, J
Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans.
Cell Metab
14
466-77
2011
Homo sapiens, Mus sp., Mus musculus
Wang, L; Luo, J; Fang, M; Jiang, G; Zhang, X; Yu, W; Wang, X
A new trick of INPP4A: Decreased expression of INPP4A in patients with temporal lobe epilepsy and pilocarpine-induced rat model.
Synapse
2012
Homo sapiens, Rattus, Hippocampus
Kim, JS; Yun, HS; Um, HD; Park, JK; Lee, KH; Kang, CM; Lee, SJ; Hwang, SG
Identification of inositol polyphosphate 4-phosphatase type II as a novel tumor resistance biomarker in human laryngeal cancer HEp-2 cells.
Cancer Biol Ther
13
2012
Homo sapiens
Vacher, J
Inpp4b is a novel negative modulator of osteoclast differentiation and a prognostic locus for human osteoporosis.
Ann N Y Acad Sci
1280
52-4
2013
Homo sapiens
Guo, ST; Chi, MN; Yang, RH; Guo, XY; Zan, LK; Wang, CY; Xi, YF; Jin, L; Croft, A; Tseng, HY; Yan, XG; Farrelly, M; Wang, FH; Lai, F; Wang, JF; Li, YP; Ackland, S; Scott, R; Agoulnik, IU; Hondermarck, H; Thorne, RF; Liu, T; Zhang, XD; Jiang, CC
INPP4B is an oncogenic regulator in human colon cancer.
Oncogene
2015
Homo sapiens
Xie, BH; He, X; Hua, RX; Zhang, B; Tan, GS; Xiong, SQ; Liu, LS; Chen, W; Yang, JY; Wang, XN; Li, HP
Mir-765 promotes cell proliferation by downregulating INPP4B expression in human hepatocellular carcinoma.
Cancer Biomark
16
405-13
2016
Homo sapiens
Ji, L; Kim, NH; Huh, SO; Rhee, HJ
Depletion of Inositol Polyphosphate 4-Phosphatase II Suppresses Callosal Axon Formation in the Developing Mice.
Mol Cells
39
501-7
2016
Mus sp.
Croft, A; Guo, ST; Sherwin, S; Farrelly, M; Yan, XG; Zhang, XD; Jiang, CC
Functional identification of a novel transcript variant of INPP4B in human colon and breast cancer cells.
Biochem Biophys Res Commun
485
47-53
2017
Homo sapiens, insertion sequences
Chen, H; Li, H; Chen, Q
INPP4B overexpression suppresses migration, invasion and angiogenesis of human prostate cancer cells.
Clin Exp Pharmacol Physiol
2017
Homo sapiens
Tang, W; Yang, L; Yang, T; Liu, M; Zhou, Y; Lin, J; Wang, K; Ding, C
INPP4B inhibits cell proliferation, invasion and chemoresistance in human hepatocellular carcinoma.
Onco Targets Ther
12
3491-3507
2019
Homo sapiens
Mangialardi, EM; Chen, K; Salmon, B; Vacher, J; Salmena, L
Investigating the duality of Inpp4b function in the cellular transformation of mouse fibroblasts.
Oncotarget
10
6378-6390
2019
Mus musculus, Transformation, Macaca mulatta polyomavirus 1
Ceyhan, Y; Zhang, M; Guo, J; Sandoval, CG; Vacher, J; Kaftanovskaya, EM; Agoulnik, AI; Agoulnik, IU
Deletion of inositol polyphosphate 4-phosphatase type-II B affects spermatogenesis in mice.
PLoS One
15
e0233163
2020
Mus sp., Homo sapiens
Wu, Y; Meng, D; Xu, X; Bao, J; You, Y; Sun, Y; Li, Y; Sun, D
Expression and functional characterization of INPP4B in gallbladder cancer patients and gallbladder cancer cells.
BMC Cancer
21
433
2021
Homo sapiens
Hakim, S; Bertucci, MC; Conduit, SE; Vuong, DL; Mitchell, CA
Inositol polyphosphate phosphatases in human disease.
Curr Top Microbiol Immunol
362
247-314
2012
Homo sapiens, Mus musculus
Pendaries, C; TronchĆØre, H; Arbibe, L; Mounier, J; Gozani, O; Cantley, L; Fry, MJ; Gaits-Iacovoni, F; Sansonetti, PJ; Payrastre, B
PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection.
EMBO J
25
1024-34
2006
Shigella flexneri
Fumet, JD; Limagne, E; Thibaudin, M; Truntzer, C; Bertaut, A; Rederstorff, E; Ghiringhelli, F
Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment.
BMC Cancer
20
748
2020
Homo sapiens
Aich, J; Mabalirajan, U; Ahmad, T; Khanna, K; Rehman, R; Agrawal, A; Ghosh, B
Resveratrol attenuates experimental allergic asthma in mice by restoring inositol polyphosphate 4 phosphatase (INPP4A).
Int Immunopharmacol
2012
Mus sp., Mus musculus
Wang, T; Holland, JW; Carrington, A; Zou, J; Secombes, CJ
Molecular and functional characterization of IL-15 in rainbow trout Oncorhynchus mykiss: a potent inducer of IFN-gamma expression in spleen leukocytes.
J Immunol
179
1475-88
2007
trout
Stjernström, A; Karlsson, C; Fernandez, OJ; Söderkvist, P; Karlsson, MG; Thunell, LK
Alterations of INPP4B, PIK3CA and pAkt of the PI3K pathway are associated with squamous cell carcinoma of the lung.
Cancer Med
3
337-48
2014
Homo sapiens
Sueta, A; Yamamoto, Y; Yamamoto-Ibusuki, M; Hayashi, M; Takeshita, T; Yamamoto, S; Iwase, H
An integrative analysis of PIK3CA mutation, PTEN, and INPP4B expression in terms of trastuzumab efficacy in HER2-positive breast cancer.
PLoS One
9
e116054
2014
Homo sapiens
Sun, Y; Ding, H; Liu, X; Li, X; Li, L
INPP4B overexpression enhances the antitumor efficacy of PARP inhibitor AG014699 in MDA-MB-231 triple-negative breast cancer cells.
Tumour Biol
2014
Homo sapiens
Ip, LR; Poulogiannis, G; Viciano, FC; Sasaki, J; Kofuji, S; Spanswick, VJ; Hochhauser, D; Hartley, JA; Sasaki, T; Gewinner, CA
Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment.
Oncotarget
6
10548-62
2015
Homo sapiens, Calloplesiops altivelis
Min, JW; Kim, KI; Kim, HA; Kim, EK; Noh, WC; Jeon, HB; Cho, DH; Oh, JS; Park, IC; Hwang, SG; Kim, JS
INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells.
Biochem Biophys Res Commun
2013
Homo sapiens
Rodgers, SJ; Ferguson, DT; Mitchell, CA; Ooms, LM
Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases.
Biosci Rep
37
2017
Mus musculus, Transformation
Sasaki, J; Kofuji, S; Itoh, R; Momiyama, T; Takayama, K; Murakami, H; Chida, S; Tsuya, Y; Takasuga, S; Eguchi, S; Asanuma, K; Horie, Y; Miura, K; Davies, EM; Mitchell, C; Yamazaki, M; Hirai, H; Takenawa, T; Suzuki, A; Sasaki, T
The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death.
Nature
465
497-501
2010
Mus sp.
Lopez, SM; Hodgson, MC; Packianathan, C; Bingol-Ozakpinar, O; Uras, F; Rosen, BP; Agoulnik, IU
Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities.
Biochem Biophys Res Commun
2013
Homo sapiens
Hodgson, MC; Deryugina, EI; Suarez, E; Lopez, SM; Lin, D; Xue, H; Gorlov, IP; Wang, Y; Agoulnik, IU
INPP4B suppresses prostate cancer cell invasion.
Cell Commun Signal
12
61
2014
Homo sapiens
Hsu, I; Yeh, CR; Slavin, S; Miyamoto, H; Netto, GJ; Tsai, YC; Muyan, M; Wu, XR; Messing, EM; Guancial, EA; Yeh, S
Estrogen receptor alpha prevents bladder cancer via INPP4B inhibited akt pathway in vitro and in vivo.
Oncotarget
5
7917-35
2014
animal, Homo sapiens, Mus musculus, Mus sp., Transformation
Sheffer, R; Bennett-Back, O; Yaacov, B; Edvardson, S; Gomori, M; Werner, M; Fahham, D; Anteby, I; Frumkin, A; Meiner, V; Elpeleg, O
Hindbrain malformation and myoclonic seizures associated with a deleterious mutation in the INPP4A gene.
Neurogenetics
16
23-6
2015
Homo sapiens, Mus sp.
Dzneladze, I; He, R; Woolley, JF; Hi Son, M; Sharobim, MH; Greenberg, SA; Gabra, M; Langlois, C; Rashid, A; Hakem, A; Ibrahimova, N; Arruda, A; Minden, MD; Salmena, L
INPP4B overexpression is associated with poor clinical outcome and therapy resistance in acute myeloid leukemia.
Leukemia
2015
Homo sapiens
Li Chew, C; Lunardi, A; Gulluni, F; Ruan, DT; Chen, M; Salmena, L; Nishino, M; Papa, A; Ng, C; Fung, J; Clohessy, JG; Sasaki, J; Sasaki, T; Bronson, RT; Hirsch, E; Pandolfi, PP
In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.
Cancer Discov
5
740-51
2015
Homo sapiens, Mus sp.
Kofuji, S; Kimura, H; Nakanishi, H; Nanjo, H; Takasuga, S; Liu, H; Eguchi, S; Nakamura, R; Itoh, R; Ueno, N; Asanuma, K; Huang, M; Koizumi, A; Habuchi, T; Yamazaki, M; Suzuki, A; Sasaki, J; Sasaki, T
INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor.
Cancer Discov
5
730-9
2015
Homo sapiens, Mus sp.
Salmena, L; Shaw, P; Fans, I; McLaughlin, ; Rosen, B; Risch, H; Mitchell, C; Sun, P; Narod, SA; Kotsopoulos, J
Prognostic value of INPP4B protein immunohistochemistry in ovarian cancer.
Eur J Gynaecol Oncol
36
260-7
2015
Homo sapiens
Tokunaga, E; Yamashita, N; Kitao, H; Tanaka, K; Taketani, K; Inoue, Y; Saeki, H; Oki, E; Oda, Y; Maehara, Y
Biological and clinical significance of loss of heterozygosity at the INPP4B gene locus in Japanese breast cancer.
Breast
25
62-8
2016
Homo sapiens
Chen, H; Li, H; Chen, Q
INPP4B reverses docetaxel resistance and epithelial-to-mesenchymal transition via the PI3K/Akt signaling pathway in prostate cancer.
Biochem Biophys Res Commun
477
467-72
2016
Homo sapiens
Strotbek, M; Schmid, S; Sįnchez-Gonzįlez, I; Boerries, M; Busch, H; Olayioye, MA
miR-181 elevates Akt signaling by co-targeting PHLPP2 and INPP4B phosphatases in luminal breast cancer.
Int J Cancer
140
2310-2320
2017
Homo sapiens
Jin, H; Yang, L; Wang, L; Yang, Z; Zhan, Q; Tao, Y; Zou, Q; Tang, Y; Xian, J; Zhang, S; Jing, Y; Zhang, L
INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia.
J Exp Clin Cancer Res
37
8
2018
Homo sapiens
Dzneladze, I; Woolley, JF; Rossell, C; Han, Y; Rashid, A; Jain, M; Reimand, J; Minden, MD; Salmena, L
SubID, a non-median dichotomization tool for heterogeneous populations, reveals the pan-cancer significance of INPP4B and its regulation by EVI1 in AML.
PLoS One
13
e0191510
2018
Homo sapiens
Chen, Y; Sun, Z; Qi, M; Wang, X; Zhang, W; Chen, C; Liu, J; Zhao, W
INPP4B restrains cell proliferation and metastasis via regulation of the PI3K/AKT/SGK pathway.
J Cell Mol Med
2018
Homo sapiens, Mus musculus
Chaudhuri, R; Khanna, K; Koundinya, D; Pattnaik, B; Vatsa, D; Agrawal, A; Ghosh, B
Novel nuclear translocation of inositol polyphosphate 4-phosphatase is associated with cell cycle, proliferation and survival.
Biochim Biophys Acta Mol Cell Res
2018
Homo sapiens
Yang, L; Ding, C; Tang, W; Yang, T; Liu, M; Wu, H; Wen, K; Yao, X; Feng, J; Luo, J
INPP4B exerts a dual function in the stemness of colorectal cancer stem-like cells through regulating Sox2 and Nanog expression.
Carcinogenesis
2019
Homo sapiens, Mus musculus
Yang, QC; Li, H; Xiao, Y; Wu, CC; Yang, SC; Sun, ZJ
Expression of inositol polyphosphate 4-phosphatase type II and the prognosis of oral squamous cell carcinoma.
Eur J Oral Sci
128
37-45
2020
Homo sapiens, Indicator
Sun, Y; Ning, X; Fan, J; Hu, J; Jiang, Y; Hu, Z; Paulo, JA; Liu, J; Qiu, X; Xu, H; Fu, S; Gygi, SP; Zhang, J; Zhou, C
Loss of tumor suppressor inositol polyphosphate 4-phosphatase type B impairs DNA double-strand break repair by destabilization of DNA tethering protein Rad50.
Cell Death Dis
11
292
2020
Homo sapiens
Liu, H; Paddock, MN; Wang, H; Murphy, CJ; Geck, RC; Navarro, AJ; Wulf, GM; Elemento, O; Haucke, V; Cantley, LC; Toker, A
The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer.
Cancer Discov
10
1226-1239
2020
Mus musculus, Mus sp.
Chaurasiya, S; Wu, W; Strom, AM; Warner, M; Gustafsson, JÅ
Estrogen receptor ? regulates AKT activity through up-regulation of INPP4B and inhibits migration of prostate cancer cell line PC-3.
Proc Natl Acad Sci U S A
117
26347-26355
2020
Homo sapiens
Li, J; Yang, J; Hua, L; Wang, R; Li, H; Zhang, C; Zhang, H; Li, S; Zhu, L; Su, H
Ese-3 contributes to colon cancer progression by downregulating EHD2 and transactivating INPP4B.
Am J Cancer Res
11
92-107
2021
Homo sapiens
Zhang, M; Ceyhan, Y; Kaftanovskaya, EM; Vasquez, JL; Vacher, J; Knop, FK; Nathanson, L; Agoulnik, AI; Ittmann, MM; Agoulnik, IU
INPP4B protects from metabolic syndrome and associated disorders.
Commun Biol
4
416
2021
Mus sp.
Hamila, SA; Ooms, LM; Rodgers, SJ; Mitchell, CA
The INPP4B paradox: Like PTEN, but different.
Adv Biol Regul
82
100817
2021
Homo sapiens
Wang, F; Xi, SY; Hao, WW; Yang, XH; Deng, L; Xu, YX; Wu, XY; Zeng, L; Guo, KH; Wang, HY
Mutational landscape of primary pulmonary salivary gland-type tumors through targeted next-generation sequencing.
Lung Cancer
160
1-7
2021
Homo sapiens
Dyson, JM; Fedele, CG; Davies, EM; Becanovic, J; Mitchell, CA
Phosphoinositide phosphatases: just as important as the kinases.
Subcell Biochem
58
215-79
2012
Homo sapiens
Maekawa, M; Terasaka, S; Mochizuki, Y; Kawai, K; Ikeda, Y; Araki, N; Skolnik, EY; Taguchi, T; Arai, H
Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis.
Proc Natl Acad Sci U S A
111
E978-87
2014
Caenorhabditis elegans
Mäki-Nevala, S; Sarhadi, VK; Knuuttila, A; Scheinin, I; Ellonen, P; Lagström, S; Rönty, M; Kettunen, E; Husgafvel-Pursiainen, K; Wolff, H; Knuutila, S
Driver Gene and Novel Mutations in Asbestos-Exposed Lung Adenocarcinoma and Malignant Mesothelioma Detected by Exome Sequencing.
Lung
2015
Homo sapiens
Erneux, C; Ghosh, S; Ramos, AR; Edimo, WE
New functions of the inositol polyphosphate 5-phosphatases in cancer.
Curr Pharm Des
2016
Homo sapiens
Agrawal, A; Sinha, A; Ahmad, T; Aich, J; Singh, P; Sharma, A; Ghosh, B
Maladaptation Of Critical Cellular Functions In Asthma: A Bioinformatic Analysis.
Physiol Genomics
2009
Mus musculus, Mus sp.
Won, JR; Gao, D; Chow, C; Cheng, J; Lau, SY; Ellis, MJ; Perou, CM; Bernard, PS; Nielsen, TO
A survey of immunohistochemical biomarkers for basal-like breast cancer against a gene expression profile gold standard.
Mod Pathol
2013
Homo sapiens
Lemcke, S; Müller, S; Möller, S; Schillert, A; Ziegler, A; Cepok-Kauffeld, S; Comabella, M; Montalban, X; Rülicke, T; Nandakumar, KS; Hemmer, B; Holmdahl, R; Pahnke, J; Ibrahim, SM
Nerve conduction velocity is regulated by the inositol polyphosphate-4-phosphatase II gene.
Am J Pathol
184
2420-9
2014
Mus musculus, Mus sp.
Xu, H; Sun, H; Zhang, H; Liu, J; Fan, F; Li, Y; Ning, X; Sun, Y; Dai, S; Liu, B; Gao, M; Fu, S; Zhou, C
An ShRNA Based Genetic Screen Identified Sesn2 as a Potential Tumor Suppressor in Lung Cancer via Suppression of Akt-mTOR-p70S6K Signaling.
PLoS One
10
e0124033
2015
Transformation
Zhang, F; Zhu, J; Li, J; Zhu, F; Zhang, P
IRF2-INPP4B axis participates in the development of acute myeloid leukemia by regulating cell growth and survival.
Gene
627
9-14
2017
Homo sapiens
Zhang, F; Zhu, K; Liu, L; Zhu, J; Li, J; Zhang, P; Hu, Z; Yuan, Y
IRF2-INPP4B axis inhibits apoptosis of acute myeloid leukaemia cells via regulating T helper 1/2 cell differentiation.
Cell Biochem Funct
2020
Homo sapiens
Maruyama, N; Umikawa, M; Matsumoto, H; Maruyama, T; Nishihara, K; Nakasone, T; Matayoshi, A; Goto, T; Hirano, F; Arasaki, A; Nakamura, H; Matsuzaki, G; Takaesu, G
miR-935 Inhibits Oral Squamous Cell Carcinoma and Targets Inositol Polyphosphate-4-phosphatase Type IA (INPP4A).
Anticancer Res
40
6101-6113
2020
Homo sapiens
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