Disease on EC 3.1.3.66 - phosphatidylinositol-3,4-bisphosphate 4-phosphatase
Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Adenocarcinoma
Inositol polyphosphate-4-phosphatase type II plays critical roles in the modulation of cadherin-mediated adhesion dynamics of pancreatic ductal adenocarcinomas.
Adenocarcinoma of Lung
Loss of tumor suppressor inositol polyphosphate 4-phosphatase type B impairs DNA double-strand break repair by destabilization of DNA tethering protein Rad50.
Asthma
A genetic variation in inositol polyphosphate 4 phosphatase a enhances susceptibility to asthma.
Asthma
Resveratrol attenuates experimental allergic asthma in mice by restoring inositol polyphosphate 4 phosphatase (INPP4A).
Asthma
Secretory Inositol Polyphosphate 4-Phosphatase Protects Against Airway Inflammation and Remodeling.
Ataxia
Elimination of INPP4A and SLC5A7 as candidate genes for congenital progressive ataxia and spastic paresis in pigs.
Breast Neoplasms
A survey of immunohistochemical biomarkers for basal-like breast cancer against a gene expression profile gold standard.
Breast Neoplasms
An integrative analysis of PIK3CA mutation, PTEN, and INPP4B expression in terms of trastuzumab efficacy in HER2-positive breast cancer.
Breast Neoplasms
Basal biomarkers Nestin and INPP4b accurately identify intrinsic subtype in breast cancers that are weakly positive for estrogen receptor.
Breast Neoplasms
Basal biomarkers nestin and INPP4B predict gemcitabine benefit in metastatic breast cancer: Samples from the phase III SBG0102 clinical trial.
Breast Neoplasms
Biological and clinical significance of loss of heterozygosity at the INPP4B gene locus in Japanese breast cancer.
Breast Neoplasms
Functional identification of a novel transcript variant of INPP4B in human colon and breast cancer cells.
Breast Neoplasms
Genetic interactions between INPP4B and RAD50 is prognostic of breast cancer survival.
Breast Neoplasms
Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers.
Breast Neoplasms
INPP4B and PTEN Loss Leads to PI-3,4-P2 Accumulation and Inhibition of PI3K in TNBC.
Breast Neoplasms
INPP4B and RAD50 have an interactive effect on survival after breast cancer.
Breast Neoplasms
INPP4B promotes PI3K?-dependent late endosome formation and Wnt/?-catenin signaling in breast cancer.
Breast Neoplasms
Investigating the duality of Inpp4b function in the cellular transformation of mouse fibroblasts.
Breast Neoplasms
miR-181 elevates Akt signaling by co-targeting PHLPP2 and INPP4B phosphatases in luminal breast cancer.
Breast Neoplasms
PI3K Pathway Activation in High-Grade Ductal Carcinoma In Situ--Implications for Progression to Invasive Breast Carcinoma.
Breast Neoplasms
Targeting mTOR pathway inhibits tumor growth in different molecular subtypes of triple-negative breast cancers.
Carcinogenesis
Epigenetic inactivation of inositol polyphosphate 4-phosphatase B (INPP4B), a regulator of PI3K/AKT signaling pathway in EBV-associated nasopharyngeal carcinoma.
Carcinogenesis
In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.
Carcinogenesis
Loss of tumor suppressor inositol polyphosphate 4-phosphatase type B impairs DNA double-strand break repair by destabilization of DNA tethering protein Rad50.
Carcinogenesis
MicroRNA-590-3p promotes cell proliferation and invasion by targeting inositol polyphosphate 4-phosphatase type II in human prostate cancer cells.
Carcinogenesis
Mir-765 promotes cell proliferation by downregulating INPP4B expression in human hepatocellular carcinoma.
Carcinogenesis
Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1.
Carcinogenesis
The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer.
Carcinoma
Alterations of INPP4B, PIK3CA and pAkt of the PI3K pathway are associated with squamous cell carcinoma of the lung.
Carcinoma
Analysis of genes involved in the PI3K/Akt pathway in radiation- and MNU-induced rat mammary carcinomas.
Carcinoma
Expression of inositol polyphosphate 4-phosphatase type II and the prognosis of oral squamous cell carcinoma.
Carcinoma
INPP4B is highly expressed in prostate intermediate cells and its loss of expression in prostate carcinoma predicts for recurrence and poor long term survival.
Carcinoma
INPP4B restrains cell proliferation and metastasis via regulation of the PI3K/AKT/SGK pathway.
Carcinoma
MicroRNA-4286 promotes esophageal carcinoma development by targeting INPP4A to evoke the JAK2/STAT3 pathway activation.
Carcinoma
Upregulation of MicroRNA-935 Promotes the Malignant Behaviors of Pancreatic Carcinoma PANC-1 Cells via Targeting Inositol Polyphosphate 4-Phosphatase Type I Gene (INPP4A).
Carcinoma
[Effects of long non-coding RNA FLJ37505 on the proliferation and migration of bladder cancer cells].
Carcinoma, Ductal
PI3K Pathway Activation in High-Grade Ductal Carcinoma In Situ--Implications for Progression to Invasive Breast Carcinoma.
Carcinoma, Hepatocellular
INPP4B inhibits cell proliferation, invasion and chemoresistance in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Mir-765 promotes cell proliferation by downregulating INPP4B expression in human hepatocellular carcinoma.
Carcinoma, Intraductal, Noninfiltrating
PI3K Pathway Activation in High-Grade Ductal Carcinoma In Situ--Implications for Progression to Invasive Breast Carcinoma.
Carcinoma, Non-Small-Cell Lung
Overexpression of miR-4443 promotes the resistance of non-small cell lung cancer cells to epirubicin by targeting INPP4A and regulating the activation of JAK2/STAT3 pathway.
Carcinoma, Squamous Cell
Alterations of INPP4B, PIK3CA and pAkt of the PI3K pathway are associated with squamous cell carcinoma of the lung.
Colonic Neoplasms
Ese-3 contributes to colon cancer progression by downregulating EHD2 and transactivating INPP4B.
Colonic Neoplasms
Investigating the duality of Inpp4b function in the cellular transformation of mouse fibroblasts.
Colonic Neoplasms
Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases.
Colorectal Neoplasms
Down-regulation of Inositol Polyphosphate 4-Phosphatase Type II Expression in Colorectal Carcinoma.
Colorectal Neoplasms
Inactivating Frameshift Mutation of INPP4B Encoding a PI3K Pathway Phosphatase in Gastric and Colorectal Cancers.
Colorectal Neoplasms
INPP4B exerts a dual function in the stemness of colorectal cancer stem-like cells through regulating Sox2 and Nanog expression.
Colorectal Neoplasms
INPP4B promotes colorectal cancer cell proliferation by activating mTORC1 signaling and cap-dependent translation.
Colorectal Neoplasms
MiR-1290 Contributes to Colorectal Cancer Cell Proliferation by Targeting INPP4B.
Drug Resistant Epilepsy
Inositol phosphatase INPP4A inhibits the apoptosis of in vitro neurons with characteristic of intractable epilepsy by reducing intracellular Ca2+ concentration.
Endometrial Neoplasms
Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment.
Epilepsies, Myoclonic
Hindbrain malformation and myoclonic seizures associated with a deleterious mutation in the INPP4A gene.
Epilepsy
A new trick of INPP4A: Decreased expression of INPP4A in patients with temporal lobe epilepsy and pilocarpine-induced rat model.
Epilepsy
Inositol phosphatase INPP4A inhibits the apoptosis of in vitro neurons with characteristic of intractable epilepsy by reducing intracellular Ca2+ concentration.
Epilepsy, Temporal Lobe
A new trick of INPP4A: Decreased expression of INPP4A in patients with temporal lobe epilepsy and pilocarpine-induced rat model.
Gallbladder Neoplasms
Expression and functional characterization of INPP4B in gallbladder cancer patients and gallbladder cancer cells.
Infections
Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model.
Intellectual Disability
Whole exome sequencing identified a novel nonsense INPP4A mutation in a family with intellectual disability.
Laryngeal Neoplasms
Identification of inositol polyphosphate 4-phosphatase type II as a novel tumor resistance biomarker in human laryngeal cancer HEp-2 cells.
Laryngeal Neoplasms
INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells.
Leukemia
High frequency of BTG1 deletions in acute lymphoblastic leukemia in children with down syndrome.
Leukemia, Myeloid, Acute
INPP4B overexpression is associated with poor clinical outcome and therapy resistance in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Investigating the duality of Inpp4b function in the cellular transformation of mouse fibroblasts.
Lung Neoplasms
Loss of tumor suppressor inositol polyphosphate 4-phosphatase type B impairs DNA double-strand break repair by destabilization of DNA tethering protein Rad50.
Lung Neoplasms
miR-937 contributes to the lung cancer cell proliferation by targeting INPP4B.
Lung Neoplasms
Overexpression of miR-4443 promotes the resistance of non-small cell lung cancer cells to epirubicin by targeting INPP4A and regulating the activation of JAK2/STAT3 pathway.
Lymphoma
Kaposi Sarcoma in Association With an Extracavitary Primary Effusion Lymphoma Showing Unusual Intravascular Involvement: Report of a Case Harboring a FAM175A Germline Mutation.
Lymphoma, B-Cell
Biochemical and molecular aspects of aluminium chloride-induced neurotoxicity in mice and the protective role of Crocus sativus L. extraction and honey syrup.
Malaria
Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study.
Melanoma
A Tumor Suppressor Function for the Lipid Phosphatase INPP4B in Melanocytic Neoplasms.
Melanoma
INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas.
Melanoma
Investigating the duality of Inpp4b function in the cellular transformation of mouse fibroblasts.
Melanoma
Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment.
Melanoma
Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases.
Microcephaly
Hindbrain malformation and myoclonic seizures associated with a deleterious mutation in the INPP4A gene.
Multiple Sclerosis
Genetic control of nerve conduction velocity may influence multiple sclerosis phenotype.
Muscle Spasticity
Elimination of INPP4A and SLC5A7 as candidate genes for congenital progressive ataxia and spastic paresis in pigs.
Nasopharyngeal Carcinoma
Epigenetic inactivation of inositol polyphosphate 4-phosphatase B (INPP4B), a regulator of PI3K/AKT signaling pathway in EBV-associated nasopharyngeal carcinoma.
Neoplasm Metastasis
In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.
Neoplasm Metastasis
INPP4B exerts a dual function in the stemness of colorectal cancer stem-like cells through regulating Sox2 and Nanog expression.
Neoplasm Metastasis
INPP4B inhibits cell proliferation, invasion and chemoresistance in human hepatocellular carcinoma.
Neoplasm Metastasis
INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor.
Neoplasm Metastasis
INPP4B restrains cell proliferation and metastasis via regulation of the PI3K/AKT/SGK pathway.
Neoplasms
A Tumor Suppressor Function for the Lipid Phosphatase INPP4B in Melanocytic Neoplasms.
Neoplasms
Basal biomarkers Nestin and INPP4b accurately identify intrinsic subtype in breast cancers that are weakly positive for estrogen receptor.
Neoplasms
Biological and clinical significance of loss of heterozygosity at the INPP4B gene locus in Japanese breast cancer.
Neoplasms
Breast Cancer Classification Based on Proteotypes Obtained by SWATH Mass Spectrometry.
Neoplasms
Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer.
Neoplasms
Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities.
Neoplasms
Down's Syndrome and Triple Negative Breast Cancer: A Rare Occurrence of Distinctive Clinical Relationship.
Neoplasms
Down-regulation of Inositol Polyphosphate 4-Phosphatase Type II Expression in Colorectal Carcinoma.
Neoplasms
Epigenetic inactivation of inositol polyphosphate 4-phosphatase B (INPP4B), a regulator of PI3K/AKT signaling pathway in EBV-associated nasopharyngeal carcinoma.
Neoplasms
Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling.
Neoplasms
Expression and functional characterization of INPP4B in gallbladder cancer patients and gallbladder cancer cells.
Neoplasms
Expression of biomarkers in the AKT pathway correlates with malignancy and recurrence in phyllodes tumours of the breast.
Neoplasms
Expression of inositol polyphosphate 4-phosphatase type II and the prognosis of oral squamous cell carcinoma.
Neoplasms
Genetic interactions between INPP4B and RAD50 is prognostic of breast cancer survival.
Neoplasms
Identification of inositol polyphosphate 4-phosphatase type II as a novel tumor resistance biomarker in human laryngeal cancer HEp-2 cells.
Neoplasms
In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.
Neoplasms
Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers.
Neoplasms
Inositol polyphosphate 4-phosphatase type II regulation of androgen receptor activity.
Neoplasms
Inositol polyphosphate-4-phosphatase type II and rucaparib treatment inhibit the growth of osteosarcoma cells dependent on phosphoinositide 3-kinase/protein kinase B pathway.
Neoplasms
Inositol polyphosphate-4-phosphatase type II plays critical roles in the modulation of cadherin-mediated adhesion dynamics of pancreatic ductal adenocarcinomas.
Neoplasms
INPP4B As A Prognostic And Diagnostic Marker Regulates Cell Growth Of Pancreatic Cancer Via Activating AKT.
Neoplasms
INPP4B exerts a dual function in the stemness of colorectal cancer stem-like cells through regulating Sox2 and Nanog expression.
Neoplasms
INPP4B inhibits cell proliferation, invasion and chemoresistance in human hepatocellular carcinoma.
Neoplasms
INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas.
Neoplasms
INPP4B overexpression enhances the antitumor efficacy of PARP inhibitor AG014699 in MDA-MB-231 triple-negative breast cancer cells.
Neoplasms
INPP4B overexpression suppresses migration, invasion and angiogenesis of human prostate cancer cells.
Neoplasms
INPP4B promotes PI3K?-dependent late endosome formation and Wnt/?-catenin signaling in breast cancer.
Neoplasms
INPP4B restrains cell proliferation and metastasis via regulation of the PI3K/AKT/SGK pathway.
Neoplasms
INPP4B reverses docetaxel resistance and epithelial-to-mesenchymal transition via the PI3K/Akt signaling pathway in prostate cancer.
Neoplasms
INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells.
Neoplasms
Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer.
Neoplasms
Investigating the duality of Inpp4b function in the cellular transformation of mouse fibroblasts.
Neoplasms
Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment.
Neoplasms
Loss of tumor suppressor inositol polyphosphate 4-phosphatase type B impairs DNA double-strand break repair by destabilization of DNA tethering protein Rad50.
Neoplasms
MicroRNA-590-3p promotes cell proliferation and invasion by targeting inositol polyphosphate 4-phosphatase type II in human prostate cancer cells.
Neoplasms
MicroRNA-940 Targets INPP4A or GSK3? and Activates the Wnt/?-Catenin Pathway to Regulate the Malignant Behavior of Bladder Cancer Cells.
Neoplasms
miR-935 Inhibits Oral Squamous Cell Carcinoma and Targets Inositol Polyphosphate-4-phosphatase Type IA (INPP4A).
Neoplasms
Novel nuclear translocation of inositol polyphosphate 4-phosphatase is associated with cell cycle, proliferation and survival.
Neoplasms
Pancreatic intraductal tubulopapillary neoplasm is genetically distinct from intraductal papillary mucinous neoplasm and ductal adenocarcinoma.
Neoplasms
Pentraxin-3 is a PI3K signaling target that promotes stem cell-like traits in basal-like breast cancers.
Neoplasms
Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway.
Neoplasms
Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment.
Neoplasms
Proteomic Features of Colorectal Cancer Identify Tumor Subtypes Independent of Oncogenic Mutations and Independently Predict Relapse-Free Survival.
Neoplasms
Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases.
Neoplasms
SHIP2 signaling in normal and pathological situations: Its impact on cell proliferation.
Neoplasms
Targeting mTOR pathway inhibits tumor growth in different molecular subtypes of triple-negative breast cancers.
Neoplasms
The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer.
Osteoporosis
Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans.
Osteoporosis
Inpp4b is a novel negative modulator of osteoclast differentiation and a prognostic locus for human osteoporosis.
Ovarian Neoplasms
Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities.
Ovarian Neoplasms
Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling.
Ovarian Neoplasms
Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment.
Ovarian Neoplasms
Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment.
Ovarian Neoplasms
Prognostic value of INPP4B protein immunohistochemistry in ovarian cancer.
Pancreatic Neoplasms
INPP4B As A Prognostic And Diagnostic Marker Regulates Cell Growth Of Pancreatic Cancer Via Activating AKT.
Pancreatic Neoplasms
Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment.
Pancreatic Neoplasms
Upregulation of MicroRNA-935 Promotes the Malignant Behaviors of Pancreatic Carcinoma PANC-1 Cells via Targeting Inositol Polyphosphate 4-Phosphatase Type I Gene (INPP4A).
Paresis
Elimination of INPP4A and SLC5A7 as candidate genes for congenital progressive ataxia and spastic paresis in pigs.
phosphatidylinositol-3,4-bisphosphate 4-phosphatase deficiency
The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer.
Prostatic Neoplasms
A Tumor Suppressor Function for the Lipid Phosphatase INPP4B in Melanocytic Neoplasms.
Prostatic Neoplasms
Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer.
Prostatic Neoplasms
Effects of INPP4B gene transfection combined with PARP inhibitor on castration therapy-resistant prostate cancer cell line, PC3.
Prostatic Neoplasms
Estrogen receptor ? regulates AKT activity through up-regulation of INPP4B and inhibits migration of prostate cancer cell line PC-3.
Prostatic Neoplasms
Inositol polyphosphate 4-phosphatase type II regulation of androgen receptor activity.
Prostatic Neoplasms
INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor.
Prostatic Neoplasms
INPP4B overexpression suppresses migration, invasion and angiogenesis of human prostate cancer cells.
Prostatic Neoplasms
INPP4B reverses docetaxel resistance and epithelial-to-mesenchymal transition via the PI3K/Akt signaling pathway in prostate cancer.
Prostatic Neoplasms
MicroRNA-590-3p promotes cell proliferation and invasion by targeting inositol polyphosphate 4-phosphatase type II in human prostate cancer cells.
Prostatic Neoplasms
Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment.
Prostatic Neoplasms
Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases.
Prostatic Neoplasms
Whole transcriptome sequencing reveals extensive unspliced mRNA in metastatic castration-resistant prostate cancer.
Sarcoma
Kaposi Sarcoma in Association With an Extracavitary Primary Effusion Lymphoma Showing Unusual Intravascular Involvement: Report of a Case Harboring a FAM175A Germline Mutation.
Seizures
A new trick of INPP4A: Decreased expression of INPP4A in patients with temporal lobe epilepsy and pilocarpine-induced rat model.
Seizures
Hindbrain malformation and myoclonic seizures associated with a deleterious mutation in the INPP4A gene.
Squamous Cell Carcinoma of Head and Neck
Expression of inositol polyphosphate 4-phosphatase type II and the prognosis of oral squamous cell carcinoma.
Teratoma
Role of the inositol polyphosphate-4-phosphatase type II Inpp4b in the generation of ovarian teratomas.
Thyroid Neoplasms
In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.
Thyroid Neoplasms
INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor.
Triple Negative Breast Neoplasms
Down's Syndrome and Triple Negative Breast Cancer: A Rare Occurrence of Distinctive Clinical Relationship.
Triple Negative Breast Neoplasms
INPP4B overexpression enhances the antitumor efficacy of PARP inhibitor AG014699 in MDA-MB-231 triple-negative breast cancer cells.
Triple Negative Breast Neoplasms
INPP4B promotes PI3K?-dependent late endosome formation and Wnt/?-catenin signaling in breast cancer.
Triple Negative Breast Neoplasms
The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer.
Urinary Bladder Neoplasms
Estrogen receptor alpha prevents bladder cancer via INPP4B inhibited akt pathway in vitro and in vivo.
Urinary Bladder Neoplasms
MicroRNA-940 Targets INPP4A or GSK3? and Activates the Wnt/?-Catenin Pathway to Regulate the Malignant Behavior of Bladder Cancer Cells.
Uterine Cervical Neoplasms
INPP4B restrains cell proliferation and metastasis via regulation of the PI3K/AKT/SGK pathway.
html completed