Reference on EC 3.1.3.66 - phosphatidylinositol-3,4-bisphosphate 4-phosphatase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Howell, S.; Barnaby, R.J.; Rowe, T.; Ragan, C.I.; Gee, N.S.
Evidence for at least four different inositol bisphosphatases in bovine brain
Eur. J. Biochem.
183
169-172
1989
Bos taurus
Munday, A.D.; Norris, F.A.; Caldwell, K.K.; Brown, S.; Majerus, P.W.; Mitchell, C.A.
The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol
Proc. Natl. Acad. Sci. USA
96
3640-3645
1999
Homo sapiens
Norris, F.A.; Auethavekiat, V.; Majerus, P.W.
The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase
J. Biol. Chem.
270
16128-16133
1995
Rattus norvegicus (Q62784), Homo sapiens (Q96PE3), Homo sapiens
Norris, F.A.; Atkins, R.C.; Majerus, P.W.
The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family
J. Biol. Chem.
272
23859-23864
1997
Homo sapiens (Q96PE3), Homo sapiens, Rattus norvegicus (Q9QWG5)
Norris, F.A.; Atkins, R.C.; Majerus, P.W.
Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human platelets
J. Biol. Chem.
272
10987-10989
1997
Homo sapiens
Ivetac, I.; Munday, A.D.; Kisseleva, M.V.; Zhang, X.M.; Luff, S.; Tiganis, T.; Whisstock, J.C.; Rowe, T.; Majerus, P.W.; Mitchell, C.A.
The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane
Mol. Biol. Cell
16
2218-2233
2005
Homo sapiens
Sharma, M.; Batra, J.; Mabalirajan, U.; Sharma, S.; Nagarkatti, R.; Aich, J.; Sharma, S.K.; Niphadkar, P.V.; Ghosh, B.
A genetic variation in inositol polyphosphate 4 phosphatase A enhances susceptibility to asthma
Am. J. Respir. Crit. Care Med.
177
712-719
2008
Homo sapiens (Q96PE3), Homo sapiens
Jeynov, B.; Lay, D.; Schmidt, F.; Tahirovic, S.; Just, W.W.
Phosphoinositide synthesis and degradation in isolated rat liver peroxisomes
FEBS Lett.
580
5917-5924
2006
Rattus norvegicus
Barnache, S.; Le Scolan, E.; Kosmider, O.; Denis, N.; Moreau-Gachelin, F.
Phosphatidylinositol 4-phosphatase type II is an erythropoietin-responsive gene
Oncogene
25
1420-1423
2006
Mus musculus
Thole, J.M.; Vermeer, J.E.; Zhang, Y.; Gadella, T.W.; Nielsen, E.
Root hair defective4 encodes a phosphatidylinositol-4-phosphate phosphatase required for proper root hair development in Arabidopsis thaliana
Plant Cell
20
381-395
2008
Arabidopsis thaliana (Q9C5G5), Arabidopsis thaliana
Gewinner, C.; Wang, Z.C.; Richardson, A.; Teruya-Feldstein, J.; Etemadmoghadam, D.; Bowtell, D.; Barretina, J.; Lin, W.M.; Rameh, L.; Salmena, L.; Pandolfi, P.P.; Cantley, L.C.
Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling
Cancer Cell
16
115-125
2009
Homo sapiens
Ivetac, I.; Gurung, R.; Hakim, S.; Horan, K.A.; Sheffield, D.A.; Binge, L.C.; Majerus, P.W.; Tiganis, T.; Mitchell, C.A.
Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1
EMBO Rep.
10
487-493
2009
Mus musculus
Sachs, A.; David, S.; Haider, N.; Nystuen, A.
Patterned neuroprotection in the Inpp4a(wbl) mutant mouse cerebellum correlates with the expression of Eaat4
PLoS ONE
4
e8270
2009
Mus musculus
Marjanovic, J.; Wilson, M.; Zhang, C.; Zou, J.; Nicholas, P.; Majerus, P.
The role of inositol polyphosphate 4-phosphatase 1 in platelet function using a weeble mouse model
Adv. Enzyme Regul.
51
101-105
2011
Mus musculus
Hodgson, M.C.; Shao, L.J.; Frolov, A.; Li, R.; Peterson, L.E.; Ayala, G.; Ittmann, M.M.; Weigel, N.L.; Agoulnik, I.U.
Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer
Cancer Res.
71
572-582
2011
Homo sapiens
Fedele, C.G.; Ooms, L.M.; Ho, M.; Vieusseux, J.; OToole, S.A.; Millar, E.K.; Lopez-Knowles, E.; Sriratana, A.; Gurung, R.; Baglietto, L.; Giles, G.G.; Bailey, C.G.; Rasko, J.E.; Shields, B.J.; Price, J.T.; Majerus, P.W.; Sutherland, R.L.; Tiganis, T.; McLean, C.A.; Mitchell, C.A.
Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
Proc. Natl. Acad. Sci. USA
107
22231-22236
2010
Homo sapiens
Balakrishnan, A.; Chaillet, J.R.
Role of the inositol polyphosphate-4-phosphatase type II Inpp4b in the generation of ovarian teratomas
Dev. Biol.
373
118-129
2013
Mus musculus
Aich, J.; Mabalirajan, U.; Ahmad, T.; Agrawal, A.; Ghosh, B.
Loss-of-function of inositol polyphosphate-4-phosphatase reversibly increases the severity of allergic airway inflammation
Nat. Commun.
3
877
2012
Mus musculus
Khanna, K.; Chaudhuri, R.; Aich, J.; Pattnaik, B.; Panda, L.; Prakash, Y.S.; Mabalirajan, U.; Ghosh, B.; Agrawal, A.
Secretory inositol polyphosphate 4-phosphatase protects against airway inflammation and remodeling
Am. J. Respir. Cell Mol. Biol.
60
399-412
2018
Homo sapiens (Q96PE3), Homo sapiens, Mus musculus (Q9EPW0)
Sung, J.Y.; Na, K.; Kim, H.S.
Down-regulation of inositol polyphosphate 4-phosphatase type II expression in colorectal carcinoma
Anticancer Res.
37
5525-5531
2017
Homo sapiens (O15327), Homo sapiens
Rijal, S.; Fleming, S.; Cummings, N.; Rynkiewicz, N.K.; Ooms, L.M.; Nguyen, N.Y.; Teh, T.C.; Avery, S.; McManus, J.F.; Papenfuss, A.T.; McLean, C.; Guthridge, M.A.; Mitchell, C.A.; Wei, A.H.
Inositol polyphosphate 4-phosphatase II (INPP4B) is associated with chemoresistance and poor outcome in AML
Blood
125
2815-2824
2015
Homo sapiens (O15327), Homo sapiens
Zhang, B.; Wang, W.; Li, C.; Liu, R.
Inositol polyphosphate-4-phosphatase type II plays critical roles in the modulation of cadherin-mediated adhesion dynamics of pancreatic ductal adenocarcinomas
Cell Adh. Migr.
12
548-563
2018
Homo sapiens (O15327), Homo sapiens
Morioka, S.; Nigorikawa, K.; Sasaki, J.; Hazeki, K.; Kasuu, Y.; Sasaki, T.; Hazeki, O.
Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model
Innate Immun.
22
444-451
2016
Mus musculus (Q9EPW0), Mus musculus
Li, D.; Yang, J.; Ma, H.; Sun, C.; Feng, R.
Inositol polyphosphate-4-phosphatase type II and rucaparib treatment inhibit the growth of osteosarcoma cells dependent on phosphoinositide 3-kinase/protein kinase B pathway
J. Cell. Biochem.
119
9899-9909
2018
Homo sapiens (O15327), Homo sapiens
Li, H.; Wu, X.; Hou, S.; Malek, M.; Kielkowska, A.; Noh, E.; Makondo, K.J.; Du, Q.; Wilkins, J.A.; Johnston, J.B.; Gibson, S.B.; Lin, F.; Marshall, A.J.
Phosphatidylinositol-3,4-bisphosphate and its binding protein lamellipodin regulate chemotaxis of malignant B lymphocytes
J. Immunol.
196
586-595
2016
Homo sapiens (O15327)
Reed, D.E.; Shokat, K.M.
INPP4B and PTEN loss leads to PI-3,4-P2 accumulation and inhibition of PI3K in TNBC
Mol. Cancer Res.
15
765-775
2017
Homo sapiens (O15327), Homo sapiens
Zhang, M.; Suarez, E.; Vasquez, J.L.; Nathanson, L.; Peterson, L.E.; Rajapakshe, K.; Basil, P.; Weigel, N.L.; Coarfa, C.; Agoulnik, I.U.
Inositol polyphosphate 4-phosphatase type II regulation of androgen receptor activity
Oncogene
38
1121-1135
2018
Homo sapiens (O15327), Homo sapiens, Mus musculus (Q6P1Y8), Mus musculus
Nigorikawa, K.; Hazeki, K.; Sasaki, J.; Omori, Y.; Miyake, M.; Morioka, S.; Guo, Y.; Sasaki, T.; Hazeki, O.
Inositol polyphosphate-4-phosphatase type I negatively regulates phagocytosis via dephosphorylation of phagosomal PtdIns(3,4)P2
PLoS ONE
10
e0142091
2015
Mus musculus (Q9EPW0)
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