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EC Tree
IUBMB Comments This enzyme exists in two isoforms. It also acts on Ins(1,3,4,5)P4 to yield Ins(1,4,5)P3.
The taxonomic range for the selected organisms is: Homo sapiens The enzyme appears in selected viruses and cellular organisms
Synonyms
multiple inositol-polyphosphate phosphatase, (mmu)minpp1, (hsa)minpp1, taphyiia2, taphyiib, hvphyiib, hvphyiia2, inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase,
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1D-myo-inositol-1,3,4,5-tetrakisphosphate 3-phosphohydrolase
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inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase
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inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase
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inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase
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inositol tetrakisphosphate phosphomonoesterase
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inositol-1,3,4,5-tetrakisphosphate 3-phosphatase
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multiple inositol polyphosphate phosphatase
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phosphatase, inositol 1,3,4,5-tetrakisphosphate 3-
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MIPP
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additional information
distinct group within the histidine phosphatase family
additional information
structural and functional relationship between MIPP and histidine acid phosphatase
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hydrolysis of phosphoric ester
hydrolysis of phosphoric ester
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hydrolysis of phosphoric ester
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1D-myo-inositol-hexakisphosphate 5-phosphohydrolase
This enzyme exists in two isoforms. It also acts on Ins(1,3,4,5)P4 to yield Ins(1,4,5)P3.
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D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
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2,3-bisphosphoglycerate + H2O
2-phosphoglycerate + phosphate
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D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + H2O
D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate
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inositol 1,3,4,5,6-pentakisphosphate + H2O
inositol 1,4,5,6-tetrakisphosphate + phosphate
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additional information
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catalytic requirement for the C-terminus and His-370 of MIPP
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additional information
Mg2+-independent
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Colonic Neoplasms
Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia.
Neoplasms
Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19.
Neoplasms
Tumour cells can employ extracellular Ins(1,2,3,4,5,6)P(6) and multiple inositol-polyphosphate phosphatase 1 (MINPP1) dephosphorylation to improve their proliferation.
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0.0016
D-myo-Inositol 1,3,4,5-tetrakisphosphate
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0.61
2,3-bisphosphoglycerate
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recombinant enzyme, at 37°C
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0.009
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using 2,3-bisphosphoglycerate as substrate, at 37°C
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SwissProt
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(HSA)MINPP1
SwissProt
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fetal growth plate cartilage, mRNA expression
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mRNA expression
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2.5 kb mRNA expression
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2.5 kb mRNA expression
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2.5 kb mRNA expression
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additional information
not expressed in peripheral blood leukocytes
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recombinant Minpp expressed in murine ATDC-5 cells, only expressed inside the ER
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ER-based protein, N-terminal ER-targeting domain
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MINP1_HUMAN
487
0
55051
Swiss-Prot
Secretory Pathway (Reliability: 5 )
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51000
x * 51000, recombinant MIPP expressed in Escherichia coli M15, SDS-PAGE and Western blot analysis
53400
x * 53400, recombinant MIPP expressed in Escherichia coli M15, amino acid sequence analysis
55100
x * 55100, inclusive the putative signal sequence, amino acid sequence analysis
55000
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deglycosylated recombinant protein, SDS-PAGE
70000
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glycosylated recombinant protein, SDS-PAGE
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?
x * 53400, recombinant MIPP expressed in Escherichia coli M15, amino acid sequence analysis
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x * 55100, inclusive the putative signal sequence, amino acid sequence analysis
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x * 51000, recombinant MIPP expressed in Escherichia coli M15, SDS-PAGE and Western blot analysis
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H370A
mutant with less than 5% of activity of wild-type enzyme
H89A
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catalytically compromised mutant of MIPP1 that shows only 1% of the 2,3-diphosphoglycerate phosphatase activity of the wild type enzyme
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7 - 7.4
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MIPP1 activity decreases 50% when pH rises from 7.0 to 7.4
694894
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4 - 37
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MIPP1 is active at 4°C, albeit considerably less active than at 37°C
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recombinant MIPP expressed in Escherichia coli M15
Ni-Sepharose column chromatography
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located on chromosome 10q23, genomic organization
MIPP cDNA from Jurkat T-cells is cloned and expressed in Escherichia coli M15 without the ER-targeting domain, full-length sequence
expressed in Pichia pastoris
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full-length Minpp cDNA is cloned and stably overexpressed in murine ATDC-5 cells at 2fold higher levels than in wild-type ATDC-5 cells, cellular effects of overexpression
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His-tag fusion, expression in Pichia pastoris
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Ni-affinity chromatography
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Hidaka, K.; Kanematsu, T.; Caffrey, J.J.; Takeuchi, H.; Shears, S.B.; Hirata, M.
The importance to chondrocyte differentiation of changes in expression of the multiple inositol polyphosphate phosphatase
Exp. Cell Res.
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254-264
2003
Homo sapiens, Mus musculus, Oryctolagus cuniculus
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Caffrey, J.J.; Hidaka, K.; Matsuda, M.; Hirata, M.; Shears, S.B.
The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification
FEBS Lett.
442
99-104
1999
Homo sapiens (Q9UNW1), Rattus norvegicus
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Chi, H.; Tiller, G.E.; Dasouki, M.J.; Romano, P.R.; Wang, J.; O'Keefe, R.J.; Puzas, J.E.; Rosier, R.N.; Reynolds, P.R.
Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19
Genomics
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324-336
1999
Homo sapiens (Q9UNW1), Homo sapiens, Mus musculus (Q9Z2L6), Mus musculus
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Deleu, S.; Choi, K.; Pesesse, X.; Cho, J.; Sulis, M.L.; Parsons, R.; Shears, S.B.
Physiological levels of PTEN control the size of the cellular Ins(1,3,4,5,6)P5 pool
Cell. Signal.
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488-498
2006
Homo sapiens
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Cho, J.; King, J.S.; Qian, X.; Harwood, A.J.; Shears, S.B.
Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt
Proc. Natl. Acad. Sci. USA
105
5998-6003
2008
Dictyostelium discoideum, Homo sapiens, Rattus norvegicus
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