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2,3-bisphosphoglycerate + H2O
2-phosphoglycerate + phosphate
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
?
D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + H2O
D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate
-
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
inositol 1,3,4,5,6-pentakisphosphate + H2O
inositol 1,4,5,6-tetrakisphosphate + phosphate
inositol 1,3,4,6-tetrakisphosphate + H2O
?
-
very poor substrate
-
-
?
inositol 3,4,5,6-tetrakisphosphate + H2O
?
-
about 10% of activity with inositol 1,3,4,5-tetrakisphosphate
-
-
?
inositol hexakisphosphate + H2O
inositol pentakisphosphate + phosphate
myo-inositol hexakisphosphate + H2O
myo-inositol pentakisphosphate + phosphate
-
-
-
-
?
scyllo-inositol hexakisphosphate + H2O
scyllo-inositol pentakisphosphate + phosphate
-
-
-
-
?
additional information
?
-
2,3-bisphosphoglycerate + H2O
2-phosphoglycerate + phosphate
-
-
-
-
?
2,3-bisphosphoglycerate + H2O
2-phosphoglycerate + phosphate
-
-
-
-
?
2,3-bisphosphoglycerate + H2O
2-phosphoglycerate + phosphate
-
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
-
recombinant N-terminal truncated cytosolic MIPP generates inositol 1,4,5-trisphosphate in an intact cell
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
-
enzyme may be regulated by the intracellular concentrations of inositol tris- and tetrakisphosphates
-
?
inositol 1,3,4,5,6-pentakisphosphate + H2O
inositol 1,4,5,6-tetrakisphosphate + phosphate
-
-
-
-
?
inositol 1,3,4,5,6-pentakisphosphate + H2O
inositol 1,4,5,6-tetrakisphosphate + phosphate
-
-
-
-
?
inositol 1,3,4,5,6-pentakisphosphate + H2O
inositol 1,4,5,6-tetrakisphosphate + phosphate
-
-
-
-
?
inositol 1,3,4,5,6-pentakisphosphate + H2O
inositol 1,4,5,6-tetrakisphosphate + phosphate
-
-
-
-
?
inositol 1,3,4,5,6-pentakisphosphate + H2O
inositol 1,4,5,6-tetrakisphosphate + phosphate
-
-
-
?
inositol 1,3,4,5,6-pentakisphosphate + H2O
inositol 1,4,5,6-tetrakisphosphate + phosphate
-
-
-
-
?
inositol 1,3,4,5,6-pentakisphosphate + H2O
inositol 1,4,5,6-tetrakisphosphate + phosphate
-
recombinant N-terminal truncated cytosolic MIPP
-
?
inositol 1,3,4,5,6-pentakisphosphate + H2O
inositol 1,4,5,6-tetrakisphosphate + phosphate
-
inositol pentakisphosphate and inositol hexakisphosphate are likely to be the preferred substrates in vivo
-
?
inositol hexakisphosphate + H2O
inositol pentakisphosphate + phosphate
-
-
-
?
inositol hexakisphosphate + H2O
inositol pentakisphosphate + phosphate
-
-
-
?
inositol hexakisphosphate + H2O
inositol pentakisphosphate + phosphate
-
-
-
-
?
inositol hexakisphosphate + H2O
inositol pentakisphosphate + phosphate
-
-
-
-
?
inositol hexakisphosphate + H2O
inositol pentakisphosphate + phosphate
-
-
-
-
?
inositol hexakisphosphate + H2O
inositol pentakisphosphate + phosphate
-
-
at least 4 isomers: D- and/or L-inositol 1,2,4,5,6-pentakisphosphate, D-inositol 1,3,4,5,6-pentakisphosphate, D-inositol 1,2,3,4,6-pentakisphosphate and D- and/or L-inositol 1,2,3,4,5-pentakisphosphate
?
inositol hexakisphosphate + H2O
inositol pentakisphosphate + phosphate
-
recombinant N-terminal truncated cytosolic MIPP
-
-
?
inositol hexakisphosphate + H2O
inositol pentakisphosphate + phosphate
-
inositol pentakisphosphate and inositol hexakisphosphate are likely to be the preferred substrates in vivo
-
?
inositol hexakisphosphate + H2O
inositol pentakisphosphate + phosphate
-
-
-
?
additional information
?
-
catalytic requirement for the C-terminus and His-370 of MIPP
-
-
?
additional information
?
-
-
dephosphorylates inositol signaling molecules InsP5 and InsP6
-
-
?
additional information
?
-
-
Minpp is important to chondrocyte differentiation in a manner independent of inositol polyphosphate turnover
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
dephosphorylates inositol signaling molecules InsP5 and InsP6
-
-
?
additional information
?
-
-
dephosphorylates inositol signaling molecules InsP5 and InsP6
-
-
?
additional information
?
-
-
not: inositol 1,3,4-trisphosphate, inositol 1,3-bisphosphate, inositol 3,4-bisphosphate, 4-nitrophenyl phosphate
-
-
?
additional information
?
-
-
enzyme is relatively unimportant to inositol 1,3,4,5-tetrakisphosphate metabolism in vivo
-
-
?
additional information
?
-
-
MIPP mRNA is upregulated during chondrocyte hypertrophy, MIPP may aid bone mineralization and salvage the inositol moiety prior to apoptosis
-
-
?
additional information
?
-
-
inositol 1,3,4,5-tetrakisphosphate 3-phosphatase is unlikely to be an important activity in vivo
-
-
?
additional information
?
-
-
function is unrelated to the metabolism of Ca2+-mobilizing cellular signals
-
-
?
additional information
?
-
-
role in the metabolism of inositol phosphates, but probably no important participant in signal transduction
-
-
?
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Ammonium phosphate buffer
CTP
-
more effective inhibitor than GTP
Endogenous heat-stable inhibitor
-
Inositol 1,3,4,5,6-pentakisphosphate
inositol 1,3,4-trisphosphate
Inositol 1,4,5-trisphosphate
inositol 3,4,5,6-tetrakisphosphate
Inositol hexakisphosphate
UTP
-
more effective inhibitor than GTP
Ammonium phosphate buffer
-
not below 0.2 mM
Ammonium phosphate buffer
-
1 to 10 mM activates, higher concentrations are inhibitory
Cu2+
-
Endogenous heat-stable inhibitor
-
-
-
Endogenous heat-stable inhibitor
-
from soluble and particulate regions of liver cells
-
Inositol 1,3,4,5,6-pentakisphosphate
-
0.001 mM, 50% inhibition; competitive; strong, kinetics
Inositol 1,3,4,5,6-pentakisphosphate
-
competitive; strong, kinetics; turkey hemoglobin reverses
Inositol 1,3,4,5,6-pentakisphosphate
-
-
Inositol 1,3,4,5,6-pentakisphosphate
-
strong, kinetics
Inositol 1,3,4,5,6-pentakisphosphate
-
-
inositol 1,3,4-trisphosphate
-
0.05 mM, about 50% inhibition
inositol 1,3,4-trisphosphate
-
-
inositol 1,3,4-trisphosphate
-
mixed-type inhibition
Inositol 1,4,5-trisphosphate
-
0.05 mM, about 50% inhibition
Inositol 1,4,5-trisphosphate
-
product inhibition kinetics
Inositol 1,4,5-trisphosphate
-
product inhibition kinetics
inositol 3,4,5,6-tetrakisphosphate
-
0.01 mM, 40% inhibition
inositol 3,4,5,6-tetrakisphosphate
-
-
inositol 3,4,5,6-tetrakisphosphate
-
commercially available with 12% inositol 2,4,5,6-tetrakisphosphate, from turkey erythrocytes, marked inhibition, linear mixed-type inhibition
Inositol hexakisphosphate
-
mixed inhibitor, 0.001 mM, 85% inhibition; more effective than inositol pentakisphosphate; strong, kinetics
Inositol hexakisphosphate
-
competitive, turkey hemoglobin reverses; more effective than inositol pentakisphosphate; strong, kinetics
Inositol hexakisphosphate
-
-
Inositol hexakisphosphate
-
more effective than inositol pentakisphosphate; strong, kinetics
Zn2+
-
additional information
-
not inhibited by digitonin
-
additional information
-
extracts of liver, heart, kidney, testis and brain contain different amounts of endogenous inhibitors of enzyme activity
-
additional information
-
not inhibited by Mg2+, Ca2+, Li+, non-hydrolysable adenine, guanine nucleotides or deoxynucleotides
-
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Hughes, P.J.; Shears, S.B.
Inositol 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate inhibit inositol-1,3,4,5-tetrakisphosphate 3-phosphatase in rat parotid glands
J. Biol. Chem.
265
9869-9875
1990
Rattus norvegicus
brenda
Her, A.; Oberdisse, E.
Inositol 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate are inhibitors of the soluble inositol 1,3,4,5-tetrakisphosphate 3-phosphatase and the inositol 1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase from pig brain
Biochem. J.
278
219-224
1991
Sus scrofa
brenda
Cullen, P.J.; Irvine, R.F.; Drobak, B.K.; Dawson, A.P.
Inositol 1,3,4,5-tetrakisphosphate causes release of Ca2+ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate
Biochem. J.
259
931-933
1989
Mus musculus
brenda
Her, A.; Her, D.; Oberdisse, E.
Properties of a soluble inositol 1,3,4,5-tetrakisphosphate 3-phosphatase from porcine brain
Biochem. J.
270
715-719
1990
Sus scrofa
brenda
Hodgson, M.E.; Shears, S.B.
Rat liver contains a potent endogenous inhibitor of inositol 1,3,4,5-tetrakisphosphate 3-phosphatase
Biochem. J.
267
831-834
1990
Rattus norvegicus
brenda
Nogimori, K.; Hughes, P.J.; Glennon, M.C.; Hodgson, M.E.; Putney, J.W.; Shears, S.B.
Purification of an inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity from rat liver and the evaluation of its substrate specificity
J. Biol. Chem.
266
16499-16506
1991
Rattus norvegicus
brenda
Van Dijken, P.; Lammers, A.A.; Van Haastert, P.J.M.
In Dictyostelium discoideum inositol 1,3,4,5-tetrakisphosphate is dephosphorylated by a 3-phosphatase and a 1-phosphatase
Biochem. J.
308
127-130
1995
Dictyostelium discoideum
brenda
Craxton, A.; Ali, N.; Shears, S.B.
Comparison of the activities of a multiple inositol polyphosphate phosphatase obtained from several sources: a search for heterogeneity in this enzyme
Biochem. J.
305
491-498
1995
Meleagris gallopavo, Rattus norvegicus
brenda
Hidaka, K.; Kanematsu, T.; Caffrey, J.J.; Takeuchi, H.; Shears, S.B.; Hirata, M.
The importance to chondrocyte differentiation of changes in expression of the multiple inositol polyphosphate phosphatase
Exp. Cell Res.
290
254-264
2003
Oryctolagus cuniculus, Homo sapiens, Mus musculus
brenda
Yu, J.; Leibiger, B.; Yang, S.N.; Caffery, J.J.; Shears, S.B.; Leibiger, I.B.; Barker, C.J.; Berggren, P.O.
Cytosolic multiple inositol polyphosphate phosphatase in the regulation of cytoplasmic free Ca2+ concentration
J. Biol. Chem.
278
46210-46218
2003
Rattus norvegicus
brenda
Caffrey, J.J.; Hidaka, K.; Matsuda, M.; Hirata, M.; Shears, S.B.
The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification
FEBS Lett.
442
99-104
1999
Rattus norvegicus, Homo sapiens (Q9UNW1)
brenda
Chi, H.; Tiller, G.E.; Dasouki, M.J.; Romano, P.R.; Wang, J.; O'Keefe, R.J.; Puzas, J.E.; Rosier, R.N.; Reynolds, P.R.
Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19
Genomics
56
324-336
1999
Homo sapiens (Q9UNW1), Homo sapiens, Mus musculus (Q9Z2L6), Mus musculus
brenda
Deleu, S.; Choi, K.; Pesesse, X.; Cho, J.; Sulis, M.L.; Parsons, R.; Shears, S.B.
Physiological levels of PTEN control the size of the cellular Ins(1,3,4,5,6)P5 pool
Cell. Signal.
18
488-498
2006
Homo sapiens
brenda
Cho, J.; Choi, K.; Darden, T.; Reynolds, P.R.; Petitte, J.N.; Shears, S.B.
Avian multiple inositol polyphosphate phosphatase is an active phytase that can be engineered to help ameliorate the planets "phosphate crisis"
J. Biotechnol.
126
248-259
2006
Gallus gallus
brenda
Mehta, B.D.; Jog, S.P.; Johnson, S.C.; Murthy, P.P.
Lily pollen alkaline phytase is a histidine phosphatase similar to mammalian multiple inositol polyphosphate phosphatase (MINPP)
Phytochemistry
67
1874-1886
2006
Lilium longiflorum (Q0GYS1), Lilium longiflorum (Q0GYS2)
brenda
Dionisio, G.; Holm, P.B.; Brinch-Pedersen, H.
Wheat (Triticum aestivum L.) and barley (Hordeum vulgare L.) multiple inositol polyphosphate phosphatases (MINPPs) are phytases expressed during grain filling and germination
Plant Biotechnol. J.
5
325-338
2007
Hordeum vulgare (A0FHA7), Hordeum vulgare (A0FHA8), Hordeum vulgare (A0FHA9), Hordeum vulgare, Triticum aestivum (A0FHB0), Triticum aestivum (A0FHB1), Triticum aestivum (A0FHB2), Triticum aestivum (A0FHB3), Triticum aestivum
brenda
Cho, J.; King, J.S.; Qian, X.; Harwood, A.J.; Shears, S.B.
Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt
Proc. Natl. Acad. Sci. USA
105
5998-6003
2008
Dictyostelium discoideum, Homo sapiens, Rattus norvegicus
brenda