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type I inositol polyphosphate 5-phosphate
-
type I inositol-1,4,5-trisphosphate 5-phosphatase
-
D-myo-inositol 1,4,5-triphosphate 5-phosphatase
-
-
-
-
D-myo-inositol 1,4,5-trisphosphate 5-phosphatase
-
-
-
-
D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase
-
-
-
-
inosine triphosphatase
-
-
-
-
inositol 1,4,5-triphosphate 5-phosphatase
-
-
-
-
inositol 1,4,5-trisphosphate 5-monophosphatase
-
-
-
-
inositol 1,4,5-trisphosphate 5-phosphatase
inositol 1,4,5-trisphosphate phosphatase
-
-
-
-
inositol phosphate 5-phosphomonoesterase
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-
-
-
inositol polyphosphate 5-phosphatase
inositol polyphosphate-5-phosphatase
-
-
-
-
inositol trisphosphate phosphomonoesterase
-
-
-
-
inositol(1,4,5)P3 5-phosphatase
-
-
inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase
-
-
-
-
Ins(1,4,5)P3 5-phosphatase
Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase
-
-
-
-
L-myo-inositol 1,4,5-trisphosphate-monoesterase
-
-
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-
myo-Inositol 1,4,5-trisphosphate 5-phosphatase
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-
myo-inositol-1,4,5-trisphosphate 5-phosphatase
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-
phosphatase, inosine tri-5PTASE
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-
-
-
trisphosphate 5-phosphatase
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-
type I inositol polyphosphate 5-phosphatase
-
-
type I inositol-1,4,5-trisphosphate 5-phosphatase
-
-
inositol 1,4,5-trisphosphate 5-phosphatase
-
-
-
-
inositol 1,4,5-trisphosphate 5-phosphatase
-
-
inositol polyphosphate 5-phosphatase
-
-
inositol polyphosphate 5-phosphatase
-
Ins(1,4,5)P3 5-phosphatase
-
-
-
-
Ins(1,4,5)P3 5-phosphatase
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-
SHIP2
-
-
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1D-myo-inositol 1,4,5-trisphosphate + H2O
1D-myo-inositol 1,4-bisphosphate + phosphate
specific for
-
-
?
1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O
phosphatidylinositol 4-phosphate + phosphate
-
-
-
?
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O
1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate
-
-
-
-
?
1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O
1D-myo-inositol 1,2,3,4-tetrakisphosphate + phosphate
-
preferred substrate
-
-
?
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
1D-myo-inositol 1,3,4-trisphosphate + phosphate
1D-myo-inositol 1,4,5,6-tetrakisphosphate + H2O
1D-myo-inositol 1,4,6-trisphosphate + phosphate
-
-
-
-
?
1D-myo-inositol 1,4,5-trisphosphate + H2O
1D-myo-inositol 1,4-disphosphate + phosphate
-
-
-
-
?
1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O
1D-myo-inositol 2,4,6-trisphosphate + phosphate
-
low activity
-
-
?
1D-myo-inositol 3,4,5-trisphosphate + H2O
1D-myo-inositol 3,4-bisphosphate + phosphate
-
-
-
?
1D-myo-inositol 3,5-bisphosphate + H2O
1D-myo-inositol 3-phosphate + phosphate
-
-
-
?
3-hydroxybenzene 1,2,4-trisphosphate + H2O
2,3-dihydroxybenzene 1,4-bisphosphate + phosphate
-
this is the first example of its kind to illustrate that an unnatural aromatic polyphosphorylated molecule can be specifically dephosphorylated by type I Ins(1,4,5)P3 5-phosphatase. No reaction with benzene 1,2,4-trisphosphate
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
glycerophosphoinositol 4,5-bisphosphate + H2O
glycerophosphoinositol 4-phosphate + phosphate
-
at 13% of the rate of inositol 1,4,5-trisphosphate hydrolysis
-
?
inositol 1,2-cyclic 4,5-trisphosphate + H2O
?
-
poor substrate
-
-
?
inositol 4,5-bisphosphate + H2O
inositol 4-phosphate + phosphate
-
-
-
?
additional information
?
-
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
1D-myo-inositol 1,3,4-trisphosphate + phosphate
-
-
-
-
?
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
1D-myo-inositol 1,3,4-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
very poor substrate
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
very poor substrate
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
product is precursor for inositol 1,3,4,5,6-pentiskphosphate via inositol 1,3,4,6-tetraiskphosphate
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?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
additional information
?
-
-
glycerophosphoinositol 4-phosphate and inositol 1,4-bisphosphate are not hydrolyzed
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-
?
additional information
?
-
-
glycerophosphoinositol 4,5-bisphosphate is not hydrolyzed
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-
?
additional information
?
-
-
the enzyme has multiple roles in cellular signalling and may regulate distinct pathways
-
-
?
additional information
?
-
-
substrate specificity, no activity with 1D-myo-inositol 1,4,5-trisphosphate, 1-phosphatidyl-1D-myo-inositol 5-phosphate, 1D-myo-inositol 1,5-bisphosphate, and 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, overview
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-
?
additional information
?
-
-
enzyme only binds soluble inositol polyphosphates
-
-
?
additional information
?
-
isofom SHIP2 is unable to dephosphorylate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
?
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1D-myo-inositol 1,4,5-trisphosphate + H2O
1D-myo-inositol 1,4-bisphosphate + phosphate
specific for
-
-
?
1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O
phosphatidylinositol 4-phosphate + phosphate
-
-
-
?
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
1D-myo-inositol 1,3,4-trisphosphate + phosphate
-
-
-
?
1D-myo-inositol 3,4,5-trisphosphate + H2O
1D-myo-inositol 3,4-bisphosphate + phosphate
-
-
-
?
1D-myo-inositol 3,5-bisphosphate + H2O
1D-myo-inositol 3-phosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
inositol 4,5-bisphosphate + H2O
inositol 4-phosphate + phosphate
-
-
-
?
additional information
?
-
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
product is precursor for inositol 1,3,4,5,6-pentiskphosphate via inositol 1,3,4,6-tetraiskphosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
-
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
additional information
?
-
-
the enzyme has multiple roles in cellular signalling and may regulate distinct pathways
-
-
?
additional information
?
-
-
enzyme only binds soluble inositol polyphosphates
-
-
?
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Alzheimer Disease
INPP5D rs35349669 polymorphism with late-onset Alzheimer's disease: A replication study and meta-analysis.
Astrocytoma
Identification of novel genetic alterations in samples of malignant glioma patients.
Ataxia
Deletion of Inpp5a causes ataxia and cerebellar degeneration in mice.
Ataxia
INPP5K and SIL1 associated pathologies with overlapping clinical phenotypes converge through dysregulation of PHGDH.
Breast Neoplasms
Polyphenolic extract of InsP 5-ptase expressing tomato plants reduce the proliferation of MCF-7 breast cancer cells.
Carcinoma
A distinct and replicable variant of the squamous cell carcinoma gene inositol polyphosphate-5-phosphatase modifies the susceptibility of arsenic-associated skin lesions in Bangladesh.
Carcinoma
Frequent loss of inositol polyphosphate-5-phosphatase in oropharyngeal squamous cell carcinoma.
Carcinoma
Prognostic Value of Inositol Polyphosphate-5-Phosphatase Expression in Recurrent and Metastatic Cutaneous Squamous Cell Carcinoma.
Carcinoma
Random DNA fragmentation allows detection of single-copy, single-exon alterations of copy number by oligonucleotide array CGH in clinical FFPE samples.
Carcinoma, Squamous Cell
A distinct and replicable variant of the squamous cell carcinoma gene inositol polyphosphate-5-phosphatase modifies the susceptibility of arsenic-associated skin lesions in Bangladesh.
Carcinoma, Squamous Cell
Prognostic Value of Inositol Polyphosphate-5-Phosphatase Expression in Recurrent and Metastatic Cutaneous Squamous Cell Carcinoma.
Carcinoma, Squamous Cell
Random DNA fragmentation allows detection of single-copy, single-exon alterations of copy number by oligonucleotide array CGH in clinical FFPE samples.
Cardiomegaly
Inpp5f Is a Polyphosphoinositide Phosphatase That Regulates Cardiac Hypertrophic Responsiveness.
Cataract
A Recurrent Pathogenic Variant of INPP5K Underlies Autosomal Recessive Congenital Muscular Dystrophy With Cataracts and Intellectual Disability: Evidence for a Founder Effect in Southern Italy.
Cataract
INPP5K and SIL1 associated pathologies with overlapping clinical phenotypes converge through dysregulation of PHGDH.
Cataract
INPP5K variant causes autosomal recessive congenital cataract in a Pakistani family.
Cataract
Mutations in INPP5K Cause a Form of Congenital Muscular Dystrophy Overlapping Marinesco-Sjögren Syndrome and Dystroglycanopathy.
Cataract
Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital Muscular Dystrophy with Cataracts and Mild Cognitive Impairment.
Cataract
The phosphoinositide 5-phosphatase INPP5K: From gene structure to in vivo functions.
Ciliopathies
Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies.
Dehydration
Inositol polyphosphate 5-phosphatase-controlled Ins(1,4,5)P3/Ca2+ is crucial for maintaining pollen dormancy and regulating early germination of pollen.
Genetic Diseases, Inborn
Novel OCRL mutations in Chinese children with Lowe syndrome.
Glioblastoma
Identification of novel genetic alterations in samples of malignant glioma patients.
Glioma
Identification of novel genetic alterations in samples of malignant glioma patients.
Glioma
Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity.
inositol-polyphosphate 5-phosphatase deficiency
Inositol 1,4,5-trisphosphate phosphatase deficiency and malignant hyperpyrexia in swine.
Insulin Resistance
Phosphatidylinositol 3,4,5-Trisphosphate Phosphatase SKIP Links Endoplasmic Reticulum Stress in Skeletal Muscle to Insulin Resistance.
Intellectual Disability
A Recurrent Pathogenic Variant of INPP5K Underlies Autosomal Recessive Congenital Muscular Dystrophy With Cataracts and Intellectual Disability: Evidence for a Founder Effect in Southern Italy.
Intellectual Disability
INPP5K variant causes autosomal recessive congenital cataract in a Pakistani family.
Intellectual Disability
Mutations in INPP5K Cause a Form of Congenital Muscular Dystrophy Overlapping Marinesco-Sjögren Syndrome and Dystroglycanopathy.
Intellectual Disability
Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital Muscular Dystrophy with Cataracts and Mild Cognitive Impairment.
Intellectual Disability
The phosphoinositide 5-phosphatase INPP5K: From gene structure to in vivo functions.
Keratosis, Actinic
Loss of inositol polyphosphate 5-phosphatase is an early event in development of cutaneous squamous cell carcinoma.
Keratosis, Actinic
Prognostic Value of Inositol Polyphosphate-5-Phosphatase Expression in Recurrent and Metastatic Cutaneous Squamous Cell Carcinoma.
Keratosis, Actinic
The prognostic value of inositol polyphosphate 5-phosphatase in cutaneous squamous cell carcinoma.
Liver Neoplasms
The Prediction and Prognostic Significance of INPP5K Expression in Patients with Liver Cancer.
Microcephaly
Mutations in INPP5K Cause a Form of Congenital Muscular Dystrophy Overlapping Marinesco-Sjögren Syndrome and Dystroglycanopathy.
Microphthalmos
Mutations in INPP5K Cause a Form of Congenital Muscular Dystrophy Overlapping Marinesco-Sjögren Syndrome and Dystroglycanopathy.
Muscular Diseases
INPP5K and SIL1 associated pathologies with overlapping clinical phenotypes converge through dysregulation of PHGDH.
Muscular Dystrophies
A Recurrent Pathogenic Variant of INPP5K Underlies Autosomal Recessive Congenital Muscular Dystrophy With Cataracts and Intellectual Disability: Evidence for a Founder Effect in Southern Italy.
Muscular Dystrophies
Bidirectional interconversion between PtdIns4P and PtdIns(4,5)P2 is required for autophagic lysosome reformation and protection from skeletal muscle disease.
Muscular Dystrophies
Defective lysosome reformation during autophagy causes skeletal muscle disease.
Muscular Dystrophies
INPP5K variant causes autosomal recessive congenital cataract in a Pakistani family.
Muscular Dystrophies
Mutations in INPP5K Cause a Form of Congenital Muscular Dystrophy Overlapping Marinesco-Sjögren Syndrome and Dystroglycanopathy.
Muscular Dystrophies
Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital Muscular Dystrophy with Cataracts and Mild Cognitive Impairment.
Muscular Dystrophies
The phosphoinositide 5-phosphatase INPP5K: From gene structure to in vivo functions.
Neoplasm Metastasis
A new gene panel as a marker for ESCC poor prognosis; INPP5A, TWIST1, MMP2, and EGFR.
Neoplasm Metastasis
The prognostic value of inositol polyphosphate 5-phosphatase in cutaneous squamous cell carcinoma.
Neoplasms
A new gene panel as a marker for ESCC poor prognosis; INPP5A, TWIST1, MMP2, and EGFR.
Neoplasms
Analysis of an independent tumor suppressor locus telomeric to Tp53 suggested Inpp5k and Myo1c as novel tumor suppressor gene candidates in this region.
Neoplasms
Canine Mammary Tumours Are Affected by Frequent Copy Number Aberrations, including Amplification of MYC and Loss of PTEN.
Neoplasms
Engineering PTEN function: Membrane association and activity.
Neoplasms
Loss of inositol polyphosphate 5-phosphatase is an early event in development of cutaneous squamous cell carcinoma.
Neoplasms
MiR-181a-5p Promotes Proliferation and Invasion, and Inhibits Apoptosis of Cervical Cancer Cells via Regulating Inositol Polyphosphate-5-Phosphatase A (INPP5A).
Neoplasms
MiR-661 contributed to cell proliferation of human ovarian cancer cells by repressing INPP5J expression.
Neoplasms
Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis.
Neoplasms
Prognostic Value of Inositol Polyphosphate-5-Phosphatase Expression in Recurrent and Metastatic Cutaneous Squamous Cell Carcinoma.
Neoplasms
Random DNA fragmentation allows detection of single-copy, single-exon alterations of copy number by oligonucleotide array CGH in clinical FFPE samples.
Neoplasms
SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma.
Neoplasms
The phosphoinositide 5-phosphatase INPP5K: From gene structure to in vivo functions.
Neoplasms
The Prediction and Prognostic Significance of INPP5K Expression in Patients with Liver Cancer.
Neoplasms
The Prognostic Value of DNA Methylation, Post-Translational Modifications and Correlated with Immune Infiltrates in Gynecologic Cancers.
Neoplasms
The prognostic value of inositol polyphosphate 5-phosphatase in cutaneous squamous cell carcinoma.
Neural Tube Defects
Relationship Between INPP5E Gene Expression and Embryonic Neural Development in a Mouse Model of Neural Tube Defect.
Oculocerebrorenal Syndrome
A novel OCRL1 gene mutation in a Turkish child with Lowe syndrome.
Oculocerebrorenal Syndrome
A Novel OCRL1 Mutation in a Patient with the Mild Phenotype of Lowe Syndrome.
Oculocerebrorenal Syndrome
Decreased urinary excretion of the ectodomain form of megalin (A-megalin) in children with OCRL gene mutations.
Oculocerebrorenal Syndrome
Novel OCRL mutations in Chinese children with Lowe syndrome.
Oculocerebrorenal Syndrome
The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase.
Ovarian Neoplasms
MiR-661 contributed to cell proliferation of human ovarian cancer cells by repressing INPP5J expression.
Parkinson Disease
Association analysis of NUCKS1 and INPP5K polymorphism with Parkinson's disease.
Parkinson Disease
Parkinson's Disease Risk Variant rs1109303 Regulates the Expression of INPP5K and CRK in Human Brain.
phosphoinositide 5-phosphatase deficiency
The role of Arabidopsis 5PTase13 in root gravitropism through modulation of vesicle trafficking.
Spinocerebellar Ataxias
Cerebellum-enriched protein INPP5A contributes to selective neuropathology in mouse model of spinocerebellar ataxias type 17.
Squamous Cell Carcinoma of Head and Neck
Frequent loss of inositol polyphosphate-5-phosphatase in oropharyngeal squamous cell carcinoma.
Thymoma
Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.
Uterine Cervical Neoplasms
MiR-181a-5p Promotes Proliferation and Invasion, and Inhibits Apoptosis of Cervical Cancer Cells via Regulating Inositol Polyphosphate-5-Phosphatase A (INPP5A).
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0.021
2,3-dihydroxybenzene 1,4-bisphosphate
Homo sapiens
-
in the presence of 1 mM Ins-(1,4,5)P3 as substrate
0.068
3-benzyloxybenzene 1,2,4-trisphosphate
Homo sapiens
-
IC50 value is obtained in the presence of 1 microM D-myo-inositol 1,4,5-trisphosphate as substrate
0.021
3-hydroxybenzene 1,2,4-trisphosphate
Homo sapiens
-
IC50 value is obtained in the presence of 1 microM D-myo-inositol 1,4,5-trisphosphate as substrate
0.098
benzene 1,2,3,4-tetrakisphosphate
Homo sapiens
-
IC50 value is obtained in the presence of 1 microM D-myo-inositol 1,4,5-trisphosphate as substrate 6
0.078
benzene 1,2,3,5-tetrakisphosphate
Homo sapiens
-
IC50 value is obtained in the presence of 1 microM D-myo-inositol 1,4,5-trisphosphate as substrate 6
0.086
benzene 1,2,3-trisphosphate
Homo sapiens
-
IC50 value is obtained in the presence of 1 microM D-myo-inositol 1,4,5-trisphosphate as substrate
0.004
benzene 1,2,4,5-tetrakisphosphate
Homo sapiens
-
IC50 value is obtained in the presence of 1 microM D-myo-inositol 1,4,5-trisphosphate as substrate
0.014
benzene 1,2,4-trisphosphate
0.016
benzene 1,3,5-trisphosphate
Homo sapiens
-
IC50 value is obtained in the presence of 1 microM D-myo-inositol 1,4,5-trisphosphate as substrate
0.001
biphenyl 2,3',4,5',6-pentakisphosphate
Homo sapiens
-
IC50 value is obtained in the presence of 1 microM D-myo-inositol 1,4,5-trisphosphate as substrate
additional information
benzene 1,2-bisphosphate
Homo sapiens
-
IC value is higher than 0.2 mM, IC50 value is obtained in the presence of 1 microM D-myo-inositol 1,4,5-trisphosphate as substrate
0.014
benzene 1,2,4-trisphosphate
Homo sapiens
-
in the presence of 1 mM Ins-(1,4,5)P3 as substrate
0.014
benzene 1,2,4-trisphosphate
Homo sapiens
-
potential mimic of D-myo-inositol 1,4,5-trisphosphate, IC50 value is obtained in the presence of 1 microM D-myo-inositol 1,4,5-trisphosphate as substrate
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Downes, C.P.; Mussat, M.C.; Michell, R.H.
The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane
Biochem. J.
203
169-177
1982
Homo sapiens
brenda
Connolly, T.M.; Bansal, V.S.; Bross, T.E.; Irvine, R.F.; Majerus, P.W.
The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes
J. Biol. Chem.
262
2146-2149
1987
Homo sapiens
brenda
Mitchell, C.A.; Connolly, T.M.; Majerus, P.W.
Identification and isolation of a 75-kDa inositol polyphosphate-5-phosphatase from human platelets
J. Biol. Chem.
264
8873-8877
1989
Homo sapiens
brenda
Fowler, C.J.; Brnnstrm, G.
Kinetic and inhibitor profiles of soluble and particulate inositol 1,4-5-trisphosphate 5-phosphatase from GH3 and IMR-32 cells
Biochem. J.
271
735-742
1990
Homo sapiens, Rattus norvegicus
brenda
Hodgkin, M.; Parry, J.B.; Michell, R.H.; Kirk, C.J.
Generation of plasma membrane domains in polarized epithelial cells: role of cell-cell contacts and assembly of the membrane cytoskeleton
Biochem. Soc. Trans.
19
1055
1991
Bos taurus, Ovis aries, Homo sapiens, Sus scrofa
brenda
Safrany, S.T.; Mills, S.J.; Liu, C.; Lampe, D.; Noble, N.J.; Nahorski, S.R.; Potter, B.V.L.
Design of potent and selective inhibitors of myo-inositol 1,4,5-trisphosphate 5-phosphatase
Biochemistry
33
10763-10769
1994
Homo sapiens, Rattus norvegicus
brenda
Hodgkin, M.; Craxton, A.; Parry, J.B.; Hughes, P.J.; Potter, B.V.L.; Michell, R.H.; Kirk, C.J.
Bovine testis and human erythrocytes contain different subtypes of membrane-associated Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphomonoesterases
Biochem. J.
297
637-645
1994
Bos taurus, Homo sapiens
brenda
Jefferson, A.B.; Majerus, P.W.
Properties of type II inositol polyphosphate 5-phosphatase
J. Biol. Chem.
270
9370-9377
1995
Homo sapiens
brenda
De Smedt, F.; Boom, A.; Pesesse, X.; Schiffmann, S.N.; Erneux, C.
Post-translational modification of human brain type I inositol-1,4,5-trisphosphate 5-phosphatase by farnesylation
J. Biol. Chem.
271
10419-10424
1996
Homo sapiens, Rattus norvegicus
brenda
Communi, D.; Lecocq, R.; Erneux, C.
Arginine 343 and 350 are two active site residues involved in substrate binding by human type I D-myo-inositol 1,4,5-trisphosphate 5-phosphatase
J. Biol. Chem.
271
11676-11683
1996
Homo sapiens
brenda
De Smedt, F.; Missiaen, L.; Parys, J.B.; Vanweyenberg, V.; De Smedt, H.; Erneux, C.
Isoprenylated human brain type I inositol 1,4,5-trisphosphate 5-phosphatase controls Ca2+ oscillations induced by ATP in Chinese hamster ovary cells
J. Biol. Chem.
272
17367-17375
1997
Homo sapiens
brenda
Erneux, C.; Govaerts, C.; Communi, D.; Pesesse, X.
The diversity and possible functions of the inositol polyphosphate 5-phosphatases
Biochim. Biophys. Acta
1436
185-199
1998
Homo sapiens
brenda
Whisstock, J.C.; Wiradjaja, F.; Waters, J.E.; Gurung, R.
The structure and function of catalytic domains within inositol polyphosphate 5-phosphatases
IUBMB Life
53
15-23
2002
Homo sapiens
brenda
Chi, Y.; Zhou, B.; Wang, W.Q.; Chung, S.K.; Kwon, Y.U.; Ahn, Y.H.; Chang, Y.T.; Tsujishita, Y.; Hurley, J.H.; Zhang, Z.Y.
Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2
J. Biol. Chem.
279
44987-44995
2004
Homo sapiens, Schizosaccharomyces pombe
brenda
Perera, I.Y.; Hung, C.Y.; Brady, S.; Muday, G.K.; Boss, W.F.
A universal role for inositol 1,4,5-trisphosphate-mediated signaling in plant gravitropism
Plant Physiol.
140
746-760
2006
Homo sapiens (Q14642), Homo sapiens
brenda
Mills, S.J.; Dozol, H.; Vandeput, F.; Backers, K.; Woodman, T.; Erneux, C.; Spiess, B.; Potter, B.V.
3-hydroxybenzene 1,2,4-trisphosphate, a novel second messenger mimic and unusual substrate for type-I myo-inositol 1,4,5-trisphosphate 5-phosphatase: Synthesis and physicochemistry
Chembiochem
7
1696-1706
2006
Homo sapiens
brenda
Wohlkoenig, A.; Senechal, M.; Dewitte, F.; Backers, K.; Erneux, C.; Villeret, V.
Expression and purification in high yield of a functionally active recombinant human Type I inositol(1,4,5)P3 5-phosphatase
Protein Expr. Purif.
55
69-74
2007
Homo sapiens
brenda
Mills, S.J.; Vandeput, F.; Trusselle, M.N.; Safrany, S.T.; Erneux, C.; Potter, B.V.
Benzene polyphosphates as tools for cell signalling: inhibition of inositol 1,4,5-trisphosphate 5-phosphatase and interaction with the pH domain of protein kinase Balpha
ChemBioChem
9
1757-1766
2008
Homo sapiens
brenda
Khodakovskaya, M.; Sword, C.; Wu, Q.; Perera, I.Y.; Boss, W.F.; Brown, C.S.; Winter Sederoff, H.
Increasing inositol (1,4,5)-trisphosphate metabolism affects drought tolerance, carbohydrate metabolism and phosphate-sensitive biomass increases in tomato
Plant Biotechnol. J.
8
170-183
2010
Homo sapiens
brenda
Braun, W.; Schein, C.
Membrane interaction and functional plasticity of inositol polyphosphate 5-phosphatases
Structure
22
664-666
2014
Homo sapiens
brenda
Tresaugues, L.; Silvander, C.; Flodin, S.; Welin, M.; Nyman, T.; Graeslund, S.; Hammarstroem, M.; Berglund, H.; Nordlund, P.
Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases
Structure
22
744-755
2014
Homo sapiens (O15357)
brenda
Wiessner, M.; Roos, A.; Munn, C.J.; Viswanathan, R.; Whyte, T.; Cox, D.; Schoser, B.; Sewry, C.; Roper, H.; Phadke, R.; Marini Bettolo, C.; Barresi, R.; Charlton, R.; Boennemann, C.G.; Abath Neto, O.; Reed, U.C.; Zanoteli, E.; Araujo Martins Moreno, C.; Ertl-Wagner, B.; Stucka, R.; De Goede, C.; Borges de Silva, T.
Mutations in INPP5K, encoding a phosphoinositide 5-phosphatase, cause congenital muscular dystrophy with cataracts and mild cognitive impairment
Am. J. Hum. Genet.
100
523-536
2017
Danio rerio (A0A2R8QKI3), Danio rerio, Homo sapiens (Q9BT40)
brenda
Seow, W.J.; Pan, W.C.; Kile, M.L.; Tong, L.; Baccarelli, A.A.; Quamruzzaman, Q.; Rahman, M.; Mostofa, G.; Rakibuz-Zaman, M.; Kibriya, M.; Ahsan, H.; Lin, X.; Christiani, D.C.
A distinct and replicable variant of the squamous cell carcinoma gene inositol polyphosphate-5-phosphatase modifies the susceptibility of arsenic-associated skin lesions in Bangladesh
Cancer
121
2222-2229
2015
Homo sapiens (Q14642)
brenda
Ooms, L.M.; Binge, L.C.; Davies, E.M.; Rahman, P.; Conway, J.R.; Gurung, R.; Ferguson, D.T.; Papa, A.; Fedele, C.G.; Vieusseux, J.L.; Chai, R.C.; Koentgen, F.; Price, J.T.; Tiganis, T.; Timpson, P.; McLean, C.A.; Mitchell, C.A.
The inositol polyphosphate 5-phosphatase PIPP regulates AKT1-dependent breast cancer growth and metastasis
Cancer Cell
28
155-169
2015
Homo sapiens (Q15735)
brenda