Reference on EC 3.1.3.43 - [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rahmatullah, M.; Roche, T.E.
Component requirements for NADH inhibition and spermine stimulation of pyruvate dehydrogenase phosphatase activity
J. Biol. Chem.
263
8106-8110
1988
Bos taurus
Reed, L.J.; Yeaman, S.J.
Pyruvate dehydrogenase
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
18
77-95
1987
Bos taurus, Neurospora crassa
-
Miernyk, J.A.; Randall, D.D.
Some properties of pea mitochondrial phospho-pyruvate dehydrogenase-phosphatase
Plant Physiol.
83
311-315
1987
Pisum sativum
Thomas, A.P.; Diggle, T.A.; Denton, R.M.
Sensitivity of pyruvate dehydrogenase phosphate phosphatase to magnesium ions. Similar effects of spermine and insulin
Biochem. J.
238
83-91
1986
Rattus norvegicus, Sus scrofa
Reed, L.J.; Damuni, Z.; Merryfield, M.L.
Regulation of mammalian pyruvate and branched-chain alpha-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation
Curr. Top. Cell. Regul.
27
41-49
1985
Bos taurus
Beatty, S.M.; Hamilton, G.A.
Inhibition of pyruvate dehydrogenase and pyruvate dehydrogenase phosphate phosphatase by glyoxylate
Bioorg. Chem.
13
14-23
1985
Rattus norvegicus
-
Damuni, Z.; Humphreys, J.S.; Reed, L.J.
Stimulation of pyruvate dehydrogenase phosphatase activity by polyamines
Biochem. Biophys. Res. Commun.
124
95-99
1984
Bos taurus
Pettit, F.H.; Teague, W.M.; Reed, L.J.
Pyruvate dehydrogenase phosphatase from bovine heart
Methods Enzymol.
90
402-407
1982
Bos taurus
Teague, W.M.; Pettit, F.H.; Wu, T.L.; Silberman, S.R.; Reed, L.J.
Purification and properties of pyruvate dehydrogenase phosphatase from bovine heart and kidney
Biochemistry
21
5585-5592
1982
Bos taurus
Pratt, M.L.; Maher, J.F.; Roche, T.E.
Purification of bovine kidney and heart pyruvate dehydrogenase phosphatase on Sepharose derivatized with the pyruvate dehydrogenase complex
Eur. J. Biochem.
125
349-355
1982
Bos taurus
Kerbey, A.L.; Randle, P.J.
Role of multi-site phosphorylation in regulation of pig heart pyruvate dehydrogenase phosphatase
FEBS Lett.
108
485-488
1979
Bos taurus, Sus scrofa
Roche, T.E.; Cate, R.L.
Purification of porcine liver pyruvate dehydrogenase complex and characterization of its catalytic and regulatory properties
Arch. Biochem. Biophys.
183
664-677
1977
Sus scrofa
Severson, D.L.; Denton, R.M.; Pask, H.T.; Randle, P.J.
Calcium and magnesium ions as effectors of adipose-tissue pyruvate dehydrogenase phosphate phosphatase
Biochem. J.
140
225-237
1974
Rattus norvegicus, Sus scrofa
Linn, T.C.; Pelley, J.W.; Pettit, F.H.; Hucho, F.; Randall, D.D.; Reed, L.J.
alpha-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart
Arch. Biochem. Biophys.
148
327-342
1972
Bos taurus
Siess, E.A.; Wieland, O.H.
Purification and characterization of pyruvate-dehydrogenase phosphatase from pig-heart muscle
Eur. J. Biochem.
26
96-105
1972
Sus scrofa
McCormack, J.G.; Bromidge, E.S.; Dawes, N.J.
Characterization of the effects of Ca2+ on the intramitochondrial Ca2+-sensitive dehydrogenases within intact rat-kidney mitochondria
Biochim. Biophys. Acta
934
282-292
1988
Rattus norvegicus
Holness, M.J.; Sugden, M.C.
Is there a role for pyruvate dehydrogenase-phosphatase in the re-activation of hepatic pyruvate dehydrogenase complex after re-feeding?
Biochem. Soc. Trans.
16
773-774
1988
Rattus norvegicus
Larner, J.; Huang, L.C.; Schwartz, C.F.W.; Oswald, A.S.; Shen, T.Y.; Kinter, M.; Tang, G.; Zeller, K.
Rat liver insulin mediator which stimulates pyruvate dehydrogenase phosphatase contains galactosamine and D-chiroinositol
Biochem. Biophys. Res. Commun.
151
1416-1426
1988
Rattus norvegicus
Midgley, P.J.W.; Rutter, G.A.; Thomas, A.P.; Denton, R.M.
The control of pyruvate dehydrogenase phosphate phosphatase by Ca2+ and Mg2+ ions
Biochem. Soc. Trans.
15
835-836
1987
Rattus norvegicus
-
Midgley P.J.W.; Rutter, G.A.; Thomas, A.P.; Denton, R.M.
Effects of Ca2+ and Mg2+ on the activity of pyruvate dehydrogenase phosphate phosphatase within toluene-permeabilized mitochondria
Biochem. J.
241
371-377
1987
Rattus norvegicus
Holness, M.J.; Sugden, M.C.
Regulation of renal and hepatic pyruvate dehydrogenase complex on carbohydrate re-feeding after starvation
Biochem. J.
241
421-425
1987
Rattus norvegicus
Uhlinger, D.J.; Yang, C.Y.; Reed, L.J.
Phosphorylation-dephosphorylation of pyruvate dehydrogenase from bakersyeast
Biochemistry
25
5673-5677
1986
Bos taurus
Mullinax, T.R.; Stepp, L.R.; Brown, J.R.; Reed, L.J.
Synthetic peptide substrates for mammalian pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase
Arch. Biochem. Biophys.
243
655-659
1985
Bos taurus
Kerbey, A.L.; Randle, P.J.; Kearns, A.
Dephosphorylation of pig heart pyruvate dehydrogenase phosphate complexes by pig heart pyruvate dehydrogenase phosphate phosphatase
Biochem. J.
195
51-59
1981
Sus scrofa
Baxter, M.A.; Coore, H.G.
Specificity of lactating rat mammary-gland pyruvate dehydrogenase phosphate phosphatase for the phosphorylated residues of the alpha-subunit
Biochem. Soc. Trans.
7
949-950
1979
Rattus norvegicus, Sus scrofa
Davis, P.F.; Pettit, F.H.; Reed, L.J.
Peptides derived from pyruvate dehydrogenase as substrates for pyruvate dehydrogenase kinase and phosphatase
Biochem. Biophys. Res. Commun.
75
541-549
1977
Bos taurus
Siess, E.A.; Wieland, O.H.
Cellular distribution of pyruvate dehydrogenase phophatase. Activity in normal, hyperinsulinized and diabetic rats
FEBS Lett.
65
163-168
1976
Rattus norvegicus
Stansbie, D.; Denton, R.M.; Bridges, B.J.; Pask, H.T.; Randle, P.J.
Regulation of pyruvate dehydrogenase and pyruvate dehydrogenase phosphate phosphatase activity in rat epididymal fat-pads
Biochem. J.
154
225-236
1976
Rattus norvegicus
Kerbey, A.L.; Randle, P.J.; Cooper, R.H.; Whitehouse, S.; Pask, H.T.; Denton, R.M.
Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A and reduced and oxidized nicotinamide-adenine dinucleotide
Biochem. J.
154
327-348
1976
Rattus norvegicus
Schuster, S.M.; Olson, M.S.
The regulation of pyruvate dehydrogenase in isolated beef heart mitochondria
J. Biol. Chem.
249
7159-7165
1974
Bos taurus
Pettit, F.H.; Roche, T.E.; Reed, L.J.
Function of Calcium ions in pyruvate dehydrogenase phosphatase activity
Biochem. Biophys. Res. Commun.
49
563-571
1972
Bos taurus
Yan, J.; Lawson, J.E.; Reed, L.J.
Role of the regulatory subunit of bovine pyruvate dehydrogenase phosphatase
Proc. Natl. Acad. Sci. USA
93
4953-4956
1996
Bos taurus
Huang, B.; Gudi, R.; Wu, P.; Harris, R.A.; Hamilton, J.; Popov, K.M.
Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation
J. Biol. Chem.
273
17680-17688
1998
Rattus norvegicus (O88483)
Chen, G.; Wang, L.; Liu, S.; Chuang, C.; Roche, T.E.
Activated function of the pyruvate dehydrogenase phosphatase through Ca2+-facilitated binding to the inner lipoyl domain of the dihydrolipoyl acetyltransferase
J. Biol. Chem.
271
28064-28070
1996
Bos taurus
Simonot, C.; Lerme, F.; Louisot, P.; Gateau-Roesch, O.
Sub-mitochondrial localization of the catalytic subunit of pyruvate dehydrogenase phosphatase
FEBS Lett.
401
158-162
1997
Mus musculus
Lawson, J.E.; Niu, X.D.; Browning, K.S.; Trong, H.L.; Yan, J.; Reed, L.J.
Molecular cloning and expression of the catalytic subunit of bovine pyruvate dehydrogenase phosphatase and sequence similarity with protein phosphatase 2C
Biochemistry
32
8987-8993
1993
Bos taurus
Cockburn, B.N.; Coore, H.G.
Starvation reduces pyruvate dehydrogenase phosphate phosphatase activity in rat kidney
Mol. Cell. Biochem.
149-150
131-136
1995
Rattus norvegicus
Bak, C.I.; Huh, J.W.; Hong, S.; Song, B.J.
Noncompetitive, Ca(2+)-independent inhibition of pyruvate dehydrogenase phosphatase by fluphenazine
Biochem. Mol. Biol. Int.
47
1029-1037
1999
Bos taurus
Galasko, G.T.F.; Abe, S.; Lilley, K.; Zhang, C.; Larner, J.
Circulating factors and insulin resistance. II. The action of the novel myo-inositol cyclic 1,2-inositol phosphate phosphoglycan insulin antagonist from human plasma in regulating pyruvate dehydrogenase phosphatase
J. Clin. Endocrinol.
81
1051-1057
1996
Bos taurus
Ito, M.; Kobashi, H.; Naito, E.; Saijo, T.; Takeda, E.; Huq, A.H.M.M.; Kuroda, Y.
Decrease of pyruvate dehydrogenase phosphatase activity in patients with congenital lactic acidemia
Clin. Chim. Acta
209
1-7
1992
Homo sapiens
Lawson, J.E.; Park, S.H.; Mattison, A.R.; Yan, J.; Reed, L.J.
Cloning, expression, and properties of the regulatory subunit of bovine pyruvate dehydrogenase phosphatase
J. Biol. Chem.
272
31625-31629
1997
Bos taurus
Song, H.; Thissen, J.; Komuniecki, R.
Novel regulation of pyruvate dehydrogenase phosphatase activity from mitochondria of the parasitic nematode, Ascaris suum
Mol. Biochem. Parasitol.
48
101-104
1991
Ascaris suum
Roche, T.E.; Baker, J.C.; Yan, X.; Hiromasa, Y.; Gong, X.; Peng, T.; Dong, J.; Turkan, A.; Kasten, S.A.
Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms
Prog. Nucleic Acid Res. Mol. Biol.
70
33-75
2001
Mammalia
Roche, T.E.; Hiromasa, Y.; Turkan, A.; Gong, X.; Peng, T.; Yan, X.; Kasten, S.A.; Bao, H.; Dong, J.
Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1
Eur. J. Biochem.
270
1050-1056
2003
Mammalia
Jacobia, S.J.; Korotchkina, L.G.; Patel, M.S.
Differential effects of two mutations at arginine-234 in the alpha subunit of human pyruvate dehydrogenase
Arch. Biochem. Biophys.
395
121-128
2001
Homo sapiens
Patel, M.S.; Korotchkina, L.G.
The biochemistry of the pyruvate dehydrogenase complex
Biochem. Mol. Biol. Educ.
31
5-15
2003
Mammalia
-
Karpova, T.; Danchuk, S.; Kolobova, E.; Popov, K.M.
Characterization of the isozymes of pyruvate dehydrogenase phosphatase: implications for the regulation of pyruvate dehydrogenase activity
Biochim. Biophys. Acta
1652
126-135
2003
Rattus norvegicus
Karpova, T.; Danchuk, S.; Huang, B.; Popov, K.M.
Probing a putative active site of the catalytic subunit of pyruvate dehydrogenase phosphatase 1 (PDP1c) by site-directed mutagenesis
Biochim. Biophys. Acta
1700
43-51
2004
Rattus norvegicus
Huang, B.; Wu, P.; Popov, K.M.; Harris, R.A.
Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidney
Diabetes
52
1371-1376
2003
Rattus norvegicus
Turkan, A.; Gong, X.; Peng, T.; Roche, T.E.
Structural requirements within the lipoyl domain for the Ca2+-dependent binding and activation of pyruvate dehydrogenase phosphatase isoform 1 or its catalytic subunit
J. Biol. Chem.
277
14976-14985
2002
Bos taurus
Soo Choi, W.; Yan, J.; McCarthy, D.B.; Hee Park, S.; Reed, L.J.
One-step purification of the recombinant catalytic subunit of pyruvate dehydrogenase phosphatase
Protein Expr. Purif.
20
128-131
2000
Bos taurus
Korotchkina, L.G.; Sidhu, S.; Patel, M.S.
R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase
Free Radic. Res.
38
1083-1092
2004
Rattus norvegicus
Turkan, A.; Hiromasa, Y.; Roche, T.E.
Formation of a complex of the catalytic subunit of pyruvate dehydrogenase phosphatase isoform 1 (PDP1c) and the L2 domain forms a Ca2+ binding site and captures PDP1c as a monomer
Biochemistry
43
15073-15085
2004
Bos taurus
Chen, H.B.; Shen, J.; Ip, Y.T.; Xu, L.
Identification of phosphatases for Smad in the BMP/DPP pathway
Genes Dev.
20
648-653
2006
Drosophila melanogaster, Homo sapiens
Maj, M.C.; MacKay, N.; Levandovskiy, V.; Addis, J.; Baumgartner, E.R.; Baumgartner, M.R.; Robinson, B.H.; Cameron, J.M.
Pyruvate dehydrogenase phosphatase deficiency: identification of the first mutation in two brothers and restoration of activity by protein complementation
J. Clin. Endocrinol. Metab.
90
4101-4107
2005
Homo sapiens
Bajotto, G.; Murakami, T.; Nagasaki, M.; Tamura, T.; Tamura, N.; Harris, R.A.; Shimomura, Y.; Sato, Y.
Downregulation of the skeletal muscle pyruvate dehydrogenase complex in the otsuka long-evans tokushima fatty rat both before and after the onset of diabetes mellitus
Life Sci.
75
2117-2130
2004
Rattus norvegicus
Piccinini, M.; Mostert, M.; Alberto, G.; Ramondetti, C.; Novi, R.F.; Dalmasso, P.; Rinaudo, M.T.
Down-regulation of pyruvate dehydrogenase phosphatase in obese subjects is a defect that signals insulin resistance
Obes. Res.
13
678-686
2005
Homo sapiens
Krause-Buchholz, U.; Gey, U.; Wuenschmann, J.; Becker, S.; Roedel, G.
YIL042c and YOR090c encode the kinase and phosphatase of the Saccharomyces cerevisiae pyruvate dehydrogenase complex
FEBS Lett.
580
2553-2560
2006
Saccharomyces cerevisiae
Leblanc, P.J.; Harris, R.A.; Peters, S.J.
Skeletal muscle fiber type comparison of pyruvate dehydrogenase phosphatase activity and isoform expression in fed and food-deprived rats
Am. J. Physiol. Endocrinol. Metab.
292
E571-E576
2007
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Hill, C.S.
Turning off Smads: identification of a Smad phosphatase
Dev. Cell
10
412-413
2006
Drosophila melanogaster, Mammalia
Vassylyev, D.G.; Symersky, J.
Crystal structure of pyruvate dehydrogenase phosphatase 1 and its functional implications
J. Mol. Biol.
370
417-426
2007
Rattus norvegicus (O88483)
Gey, U.; Czupalla, C.; Hoflack, B.; Roedel, G.; Krause-Buchholz, U.
Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases
J. Biol. Chem.
283
9759-9767
2008
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Leblanc, P.J.; Mulligan, M.; Antolic, A.; Macpherson, L.; Inglis, J.G.; Martin, D.; Roy, B.D.; Peters, S.J.
Skeletal muscle type comparison of pyruvate dehydrogenase phosphatase activity and isoform expression: effects of obesity and endurance training
Am. J. Physiol. Regul. Integr. Comp. Physiol.
295
R1224-R1230
2008
Rattus norvegicus (O88483), Rattus norvegicus (O88484)
Cameron, J.M.; Maj, M.; Levandovskiy, V.; Barnett, C.P.; Blaser, S.; Mackay, N.; Raiman, J.; Feigenbaum, A.; Schulze, A.; Robinson, B.H.
Pyruvate dehydrogenase phosphatase 1 (PDP1) null mutation produces a lethal infantile phenotype
Hum. Genet.
125
319-326
2009
Homo sapiens (Q9P0J1), Homo sapiens (Q9P2J9), Homo sapiens
McLean, P.; Kunjara, S.; Greenbaum, A.L.; Gumaa, K.; Lopez-Prados, J.; Martin-Lomas, M.; Rademacher, T.W.
Reciprocal control of pyruvate dehydrogenase kinase and phosphatase by inositol phosphoglycans. Dynamic state set by "push-pull" system
J. Biol. Chem.
283
33428-33436
2008
Bos taurus, Bos taurus (P35816)
Kato, J.; Kato, M.
Crystallization and preliminary crystallographic studies of the catalytic subunits of human pyruvate dehydrogenase phosphatase isoforms 1 and 2
Acta Crystallogr. Sect. F
66
342-345
2010
Homo sapiens (Q9P0J1), Homo sapiens (Q9P2J9), Homo sapiens
Hans, S.K.; Camara, F.; Altiti, A.; Martin-Montalvo, A.; Brautigan, D.L.; Heimark, D.; Larner, J.; Grindrod, S.; Brown, M.L.; Mootoo, D.R.
Synthesis of C-glycoside analogues of beta-galactosamine-(1-4)-3-O-methyl-D-chiro-inositol and assay as activator of protein phosphatases PDHP and PP2Calpha
Bioorg. Med. Chem.
18
1103-1110
2010
Rattus norvegicus
Love, L.; LeBlanc, P.; Inglis, J.; Bradley, N.; Choptiany, J.; Heigenhauser, G.; Peters, S.
The relationship between human skeletal muscle pyruvate dehydrogenase phosphatase activity and muscle aerobic capacity
J. Appl. Physiol.
111
427-434
2011
Homo sapiens
Shan, C.; Kang, H.B.; Elf, S.; Xie, J.; Gu, T.L.; Aguiar, M.; Lonning, S.; Hitosugi, T.; Chung, T.W.; Arellano, M.; Khoury, H.J.; Shin, D.M.; Khuri, F.R.; Boggon, T.J.; Fan, J.
Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth
J. Biol. Chem.
289
21413-21422
2014
Homo sapiens
Kaplon, J.; Zheng, L.; Meissl, K.; Chaneton, B.; Selivanov, V.A.; Mackay, G.; van der Burg, S.H.; Verdegaal, E.M.; Cascante, M.; Shlomi, T.; Gottlieb, E.; Peeper, D.S.
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
Nature
498
109-112
2013
Homo sapiens
Xing, G.; Ren, M.; O'Neill, J.T.; Sharma, P.; Verma, A.; Watson, W.D.
Pyruvate dehydrogenase phosphatase1 mRNA expression is divergently and dynamically regulated between rat cerebral cortex, hippocampus and thalamus after traumatic brain injury: a potential biomarker of TBI-induced hyper- and hypo-glycaemia and neuronal vulnerability
Neurosci. Lett.
525
140-145
2012
Rattus norvegicus
Heo, H.; Kim, H.; Youm, J.; Cho, S.; Song, I.; Lee, S.; Ko, T.; Kim, N.; Ko, K.; Rhee, B.; Han, J.
Mitochondrial pyruvate dehydrogenase phosphatase 1 regulates the early differentiation of cardiomyocytes from mouse embryonic stem cells
Exp. Mol. Med.
48
e254
2016
Mus musculus
Guo, X.; Niemi, N.; Coon, J.; Pagliarini, D.
Integrative proteomics and biochemical analyses define Ptc6p as the Saccharomyces cerevisiae pyruvate dehydrogenase phosphatase
J. Biol. Chem.
292
11751-11759
2017
Saccharomyces cerevisiae
Wang, H.; Zhang, L.; Guo, X.; Bai, Y.; Li, Y.X.; Sha, J.; Peng, C.; Wang, Y.L.; Liu, M.
MiR-195 modulates oxidative stress-induced apoptosis and mitochondrial energy production in human trophoblasts via flavin adenine dinucleotide-dependent oxidoreductase domain-containing protein 1 and pyruvate dehydrogenase phosphatase regulatory subunit
J. Hypertens.
36
306-318
2018
Homo sapiens (Q8NCN5), Homo sapiens
Barberio, M.D.; Huffman, K.M.; Giri, M.; Hoffman, E.P.; Kraus, W.E.; Hubal, M.J.
Pyruvate dehydrogenase phosphatase regulatory gene expression correlates with exercise training insulin sensitivity changes
Med. Sci. Sports Exerc.
48
2387-2397
2016
Homo sapiens
Chen, J.; Guccini, I.; Mitri, D.; Brina, D.; Revandkar, A.; Sarti, M.; Pasquini, E.; Alajati, A.; Pinton, S.; Losa, M.; Civenni, G.; Catapano, C.; Sgrignani, J.; Cavalli, A.; DAntuono, R.; Asara, J.; Morandi, A.; Chiarugi, P.; Crotti, S.; Agostini, M.
Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer
Nat. Genet.
50
219-228
2018
Homo sapiens
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