Information on EC 3.1.3.39 - streptomycin-6-phosphatase

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The expected taxonomic range for this enzyme is: Streptomyces

EC NUMBER
COMMENTARY hide
3.1.3.39
-
RECOMMENDED NAME
GeneOntology No.
streptomycin-6-phosphatase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
streptomycin 6-phosphate + H2O = streptomycin + phosphate
show the reaction diagram
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-
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of antibiotics
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-
streptomycin biosynthesis
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Streptomycin biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
streptomycin-6-phosphate phosphohydrolase
Also acts on dihydrostreptomycin 3'alpha,6-bisphosphate and streptidine 6-phosphate.
CAS REGISTRY NUMBER
COMMENTARY hide
9055-33-8
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
ATCC 14077
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Manually annotated by BRENDA team
ATCC 12628
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-
Manually annotated by BRENDA team
HUT 6037
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-
Manually annotated by BRENDA team
66
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-
Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(N'-amidino)streptidine phosphate + H2O
(N'-amidino)streptidine + phosphate
show the reaction diagram
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-
-
-
?
1,3-diamino-1,3-dideoxy-scyllo-inositol + dihydrostreptomycin 6-phosphate
?
show the reaction diagram
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-
-
-
?
1,3-diamino-1,3-dideoxy-scyllo-inositol + p-nitrophenyl phosphate
?
show the reaction diagram
-
-
-
-
?
2-deoxystreptamine + dihydrostreptomycin 6-phosphate
?
show the reaction diagram
-
-
-
-
?
2-deoxystreptamine + p-nitrophenyl phosphate
?
show the reaction diagram
-
-
-
-
?
dihydrostreptomycin 3'',6-bisphosphate + H2O
dihydrostreptomycin 3''-phosphate + phosphate
show the reaction diagram
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-
-
-
?
dihydrostreptomycin 6-phosphate
dihydrostreptomycin + phosphate
show the reaction diagram
dihydrostreptomycin 6-phosphate + H2O
dihydrostreptomycin + phosphate
show the reaction diagram
ethanolamine phosphate + H2O
?
show the reaction diagram
N-aminostreptamine phosphate + H2O
N-aminostreptamine + phosphate
show the reaction diagram
-
-
-
-
?
N1-amidinostreptamine 6-phosphate + H2O
N1-amidinostreptamine + phosphate
show the reaction diagram
-
-
-
-
?
O-phosphoryl-Tris + H2O
?
show the reaction diagram
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slow hydrolysis
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-
?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
show the reaction diagram
streptidine 6-phosphate + H2O
dihydrostreptomycin + phosphate
show the reaction diagram
streptomycin 6-phosphate + H2O
streptomycin + phosphate
show the reaction diagram
streptomycin-3''-phosphate + H2O
streptomycin + phosphate
show the reaction diagram
Tris-phosphate + H2O
?
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
dihydrostreptomycin 6-phosphate + H2O
dihydrostreptomycin + phosphate
show the reaction diagram
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final step in streptomycin biosynthesis
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?
additional information
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
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required
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
amino alcohols
phosphate
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE