Information on EC 3.1.3.39 - streptomycin-6-phosphatase

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The expected taxonomic range for this enzyme is: Streptomyces

EC NUMBER
COMMENTARY
3.1.3.39
-
RECOMMENDED NAME
GeneOntology No.
streptomycin-6-phosphatase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
streptomycin 6-phosphate + H2O = streptomycin + phosphate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
-
Streptomycin biosynthesis
-
streptomycin biosynthesis
-
SYSTEMATIC NAME
IUBMB Comments
streptomycin-6-phosphate phosphohydrolase
Also acts on dihydrostreptomycin 3'alpha,6-bisphosphate and streptidine 6-phosphate.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
phosphatase, streptomycin 6-
-
-
-
-
Sm-phosphate phosphatase
-
-
-
-
SMP Pase
-
-
-
-
streptomycin 6-phosphate phosphatase
-
-
-
-
streptomycin 6-phosphate phosphohydrolase
-
-
-
-
streptomycin-(streptidino)phosphate phosphatase
-
-
-
-
streptomycin-6-P phosphohydrolase
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
9055-33-8
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
ATCC 14077
-
-
Manually annotated by BRENDA team
ATCC 12475; little or no activity in ATCC 10971
-
-
Manually annotated by BRENDA team
Streptomyces griseus HUT 6037
HUT 6037
-
-
Manually annotated by BRENDA team
Streptomyces lividans 66
66
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(N'-amidino)streptidine phosphate + H2O
(N'-amidino)streptidine + phosphate
show the reaction diagram
-
-
-
-
?
1,3-diamino-1,3-dideoxy-scyllo-inositol + dihydrostreptomycin 6-phosphate
?
show the reaction diagram
-
-
-
-
?
1,3-diamino-1,3-dideoxy-scyllo-inositol + p-nitrophenyl phosphate
?
show the reaction diagram
-
-
-
-
?
2-deoxystreptamine + dihydrostreptomycin 6-phosphate
?
show the reaction diagram
-
-
-
-
?
2-deoxystreptamine + p-nitrophenyl phosphate
?
show the reaction diagram
-
-
-
-
?
dihydrostreptomycin 3'',6-bisphosphate + H2O
dihydrostreptomycin 3''-phosphate + phosphate
show the reaction diagram
-
-
-
-
?
dihydrostreptomycin 6-phosphate
dihydrostreptomycin + phosphate
show the reaction diagram
-
-
-
-
?
dihydrostreptomycin 6-phosphate + H2O
dihydrostreptomycin + phosphate
show the reaction diagram
-
-
-
-
?
dihydrostreptomycin 6-phosphate + H2O
dihydrostreptomycin + phosphate
show the reaction diagram
-
final step in streptomycin biosynthesis
-
-
?
N'-amidinostreptamine phosphate + H2O
N'-amidinostreptamine + phosphate
show the reaction diagram
-
-
-
-
?
N-aminostreptamine phosphate + H2O
N-aminostreptamine + phosphate
show the reaction diagram
-
-
-
-
?
O-phosphoryl-Tris + H2O
?
show the reaction diagram
-
slow hydrolysis
-
-
?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
show the reaction diagram
-
-
-
-
?
streptidine 6-phosphate + H2O
dihydrostreptomycin + phosphate
show the reaction diagram
-
-
-
-
?
streptomycin 6-phosphate + H2O
streptomycin + phosphate
show the reaction diagram
-
-
-
?
streptomycin 6-phosphate + H2O
streptomycin + phosphate
show the reaction diagram
-
-
-
?
streptomycin 6-phosphate + H2O
streptomycin + phosphate
show the reaction diagram
-
-
-
?
streptomycin 6-phosphate + H2O
streptomycin + phosphate
show the reaction diagram
-
-
-
?
streptomycin 6-phosphate + H2O
streptomycin + phosphate
show the reaction diagram
-
-
-
?
streptomycin 6-phosphate + H2O
streptomycin + phosphate
show the reaction diagram
-
-
-
?
streptomycin 6-phosphate + H2O
streptomycin + phosphate
show the reaction diagram
-
-
-
?
streptomycin 6-phosphate + H2O
streptomycin + phosphate
show the reaction diagram
-
-
-
?
streptomycin 6-phosphate + H2O
streptomycin + phosphate
show the reaction diagram
-
-
-
?
streptomycin 6-phosphate + H2O
streptomycin + phosphate
show the reaction diagram
-
-
-
?
streptomycin 6-phosphate + H2O
streptomycin + phosphate
show the reaction diagram
Streptomyces lividans 66
-
-
-
?
streptomycin 6-phosphate + H2O
streptomycin + phosphate
show the reaction diagram
Streptomyces griseus HUT 6037
-
-
-
?
streptomycin-3''-phosphate + H2O
streptomycin + phosphate
show the reaction diagram
-
-
-
-
?
streptomycin-3''-phosphate + H2O
streptomycin + phosphate
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
the enzyme and its gene might be involved in phosphate-regulation of the streptomycin-formation on both the gene and the enzyme levels
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
dihydrostreptomycin 6-phosphate + H2O
dihydrostreptomycin + phosphate
show the reaction diagram
-
final step in streptomycin biosynthesis
-
-
?
additional information
?
-
-
the enzyme and its gene might be involved in phosphate-regulation of the streptomycin-formation on both the gene and the enzyme levels
-
-
-
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Mg2+
-
required
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
-
enzyme activity appears following a phase of rapid mycelial growth on complex media
Manually annotated by BRENDA team
additional information
-
the enzyme is detected in middle and late exponential phase and in the stationary phase
Manually annotated by BRENDA team
additional information
Streptomyces griseus HUT 6037
-
the enzyme is detected in middle and late exponential phase and in the stationary phase
-
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE