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Information on EC 3.1.3.3 - phosphoserine phosphatase and Organism(s) Mus musculus and UniProt Accession Q99LS3

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.3 phosphoserine phosphatase
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This record set is specific for:
Mus musculus
UNIPROT: Q99LS3 not found.
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The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
psp, serine/threonine protein phosphatase, phosphoserine phosphatase, pspase, ctd phosphatase fcp1, serb653, serb2, l-phosphoserine phosphatase, 3-phosphoserine phosphatase, ipsp1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoserine phosphatase
-
3-phosphoserine phosphatase
-
-
-
-
CTD phosphatase fcp1
-
-
-
-
O-phosphoserine phosphohydrolase
-
-
-
-
phosphatase, phosphoserine
-
-
-
-
PSPase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
O-phosphoserine phosphohydrolase
-
CAS REGISTRY NUMBER
COMMENTARY hide
9025-73-4
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-3-phosphoserine + H2O
L-serine + phosphate
show the reaction diagram
-
final step in serine biosynthesis
-
-
?
L-phosphoserine + H2O
L-Ser + phosphate
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-3-phosphoserine + H2O
L-serine + phosphate
show the reaction diagram
-
final step in serine biosynthesis
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
D-serine
-
-
glycine
-
-
L-alanine
-
-
L-serine
-
-
additional information
-
not inhibitory: ethanolamine, L-Thr, L-Asp, L-Phe, beta-alanine
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.02
L-phosphoserine
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
C57BL/6
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
highly expressed in periventricular neural progenitors in the embryonic brain
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SERB_MOUSE
225
0
25096
Swiss-Prot
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
47000
-
mouse, gel filtration
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
partially, copurifies with serine phosphotransferase
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
in liver in response to a low protein diet
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bridgers, W.F.
Purification of mouse brain phosphoserine phosphohydrolase and phosphotransferase
Arch. Biochem. Biophys.
133
201-207
1969
Mus musculus
Manually annotated by BRENDA team
Bridgers, W.F.
Mouse brain phosphoserine phosphohydrolase and phosphotransferase
J. Biol. Chem.
242
2080-2085
1967
Mus musculus
Manually annotated by BRENDA team
Nakano, I.; Dougherty, J.D.; Kim, K.; Klement, I.; Geschwind, D.H.; Kornblum, H.I.
Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation
Stem Cells
25
1975-1984
2007
Mus musculus
Manually annotated by BRENDA team
Antflick, J.E.; Baker, G.B.; Hampson, D.R.
The effects of a low protein diet on amino acids and enzymes in the serine synthesis pathway in mice
Amino Acids
39
145-153
2009
Mus musculus (Q99LS3), Mus musculus C57BL/6 (Q99LS3)
Manually annotated by BRENDA team