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Information on EC 3.1.3.29 - N-acylneuraminate-9-phosphatase and Organism(s) Homo sapiens and UniProt Accession Q8TBE9

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.29 N-acylneuraminate-9-phosphatase
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Select one or more organisms in this record: ?
This record set is specific for:
Homo sapiens
UNIPROT: Q8TBE9 not found.
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The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
hdhd4, neu5ac-9-pase, n-acetylneuraminate-9-phosphate phosphatase, neu5ac-9-phosphate phosphatase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acylneuraminate 9-phosphatase
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-
-
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HDHD4
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haloacid dehalogenase-like hydrolase domain containing 4
N-acetylneuraminate-9-phosphate phosphatase
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N-acetylneuraminate-9-phosphate phosphohydrolase
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-
-
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N-acylneuraminic (sialic) acid 9-phosphatase
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-
-
-
N-acylneuraminic acid 9-phosphate phosphatase
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-
-
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Neu5Ac-9-Pase
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-
Neu5Ac-9-phosphate phosphatase
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-
NeuAc 9-phosphatase
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-
-
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phosphatase, acylneuraminate 9-
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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-
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PATHWAY SOURCE
PATHWAYS
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-
SYSTEMATIC NAME
IUBMB Comments
N-acylneuraminate-9-phosphate phosphohydrolase
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CAS REGISTRY NUMBER
COMMENTARY hide
37288-13-4
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
6-phospho-D-gluconate + H2O
D-gluconate + phosphate
show the reaction diagram
-
-
-
-
?
D-fructose 1,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
show the reaction diagram
-
-
-
-
?
N-acetylglucosamine 6-phosphate + H2O
N-acetylglucosamine + phosphate
show the reaction diagram
-
-
-
-
?
N-acetylneuraminate 9-phosphate + H2O
?
show the reaction diagram
-
N-acetylneuraminic acid synthesis
-
-
?
N-acetylneuraminate 9-phosphate + H2O
N-acetylneuraminate + phosphate
show the reaction diagram
N-glycolylneuraminic acid 9-phosphate + H2O
N-glycolylneuraminate + phosphate
show the reaction diagram
-
91% activity relative to N-acetylneuraminate 9-phosphate
-
?
additional information
?
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-
shows no activity towards sorbitol 6-phosphate, 3-phospho-glycerate, phospho-serine, glycerol 3-phosphate, ribulose 5-phosphate, N-acetylmannosamine 6-phosphate, arabinose 5-phosphate, ribose 5-phosphate, glucosamine 6-phosphate, phosphoglycolate, fructose 6-phosphate, glycerol 2-phosphate, glucose 6-phosphate, mannose 6-phosphate, glucose 1-phosphate, phosphoenolpyruvate, and ATP
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
N-acetylneuraminate 9-phosphate + H2O
?
show the reaction diagram
-
N-acetylneuraminic acid synthesis
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-
?
N-acetylneuraminate 9-phosphate + H2O
N-acetylneuraminate + phosphate
show the reaction diagram
-
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ca2+
-
-
N-acetylneuraminate
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-
vanadate
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-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2.7
6-phospho-D-gluconate
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in 25 mM HEPES, pH 7.4, 25 mM KCl, 1 mM MgCl2, 1 mM dithiothreitol, at 37°C
19.2
D-fructose 1,6-bisphosphate
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in 25 mM HEPES, pH 7.4, 25 mM KCl, 1 mM MgCl2, 1 mM dithiothreitol, at 37°C
5.9
N-acetylglucosamine 6-phosphate
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in 25 mM HEPES, pH 7.4, 25 mM KCl, 1 mM MgCl2, 1 mM dithiothreitol, at 37°C
0.047 - 1
N-acetylneuraminate 9-phosphate
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
15
N-acetylneuraminate
Homo sapiens
-
in 25 mM HEPES, pH 7.4, 25 mM KCl, 1 mM MgCl2, 1 mM dithiothreitol, at 37°C
0.019
vanadate
Homo sapiens
-
in 25 mM HEPES, pH 7.4, 25 mM KCl, 1 mM MgCl2, 1 mM dithiothreitol, at 37°C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.633
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-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
NANP_HUMAN
248
0
27813
Swiss-Prot
other Location (Reliability: 3)
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
albumin increases stability
-
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, stable for at least 1 week
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli as a fusion protein with a polyHis tag
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jourdian, G.W.; Swanson, A.; Watson, D.; Roseman, S.
N-Acetylneuraminic (sialic) acid 9-phosphatase
Methods Enzymol.
8
205-208
1966
Homo sapiens
-
Manually annotated by BRENDA team
Maliekal, P.; Vertommen, D.; Delpierre, G.; Van Schaftingen, E.
Identification of the sequence encoding N-acetylneuraminate-9-phosphate phosphatase
Glycobiology
16
165-172
2006
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Kim, S.H.; Constantine, K.L.; Duke, G.J.; Goldfarb, V.; Hunt, J.T.; Johnson, S.; Kish, K.; Klei, H.E.; McDonnell, P.A.; Metzler, W.J.; Mueller, L.; Poss, M.A.; Fairchild, C.R.; Bhide, R.S.
Design, synthesis, functional and structural characterization of an inhibitor of N-acetylneuraminate-9-phosphate phosphatase: observation of extensive dynamics in an enzyme/inhibitor complex
Bioorg. Med. Chem. Lett.
23
4107-4111
2013
Homo sapiens
Manually annotated by BRENDA team