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alpha-D-galactose 1-phosphate + H2O
alpha-D-galactose + phosphate
-
-
-
-
?
D-erythrose 4-phosphate + H2O
D-erythrose + phosphate
-
-
-
-
?
D-fructose 1,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
D-fructose 1-phosphate + H2O
D-fructose + phosphate
-
-
-
-
?
D-fructose 6-phosphate + H2O
D-fructose + phosphate
-
-
-
-
?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
-
-
-
-
?
D-myo-inositol 1-phosphate + H2O
D-myo-inositol + phosphate
-
-
-
-
?
D-ribose 5-phosphate + H2O
D-ribose + phosphate
-
-
-
-
?
D-xylose 5-phosphate + H2O
D-xylose + phosphate
-
-
-
-
?
DL-myo-inositol 1-phosphate + H2O
DL-myo-inositol + phosphate
-
-
-
-
?
glycerol 2-phosphate + H2O
glycerol + phosphate
-
-
-
-
?
inositol 4-phosphate + H2O
myo-inositol + phosphate
-
the inositol ring docks to the enzyme by forming four hydrogen bonds: the 2-OH group with Asp104, the 3-OH with Asp231, the 5-OH group with Thr106, and the 6-OH with the carbonyl group of main chain of Gly205
-
-
?
L-myo-inositol 1-phosphate + H2O
L-myo-inositol + phosphate
-
-
-
-
?
myo-inositol 1-phosphate + H2O
myo-inositol + phosphate
-
-
-
-
?
myo-inositol 3-phosphate + H2O
myo-inositol + phosphate
myo-inositol 4-phosphate + H2O
myo-inositol + phosphate
-
-
-
-
?
myo-inositol 5-phosphate + H2O
myo-inositol + phosphate
myo-inositol 6-phosphate + H2O
myo-inositol + phosphate
additional information
?
-
myo-inositol 3-phosphate + H2O
myo-inositol + phosphate
-
-
-
-
?
myo-inositol 3-phosphate + H2O
myo-inositol + phosphate
-
the substrate shows a similar binding structure as inositol 5-phosphate
-
-
?
myo-inositol 5-phosphate + H2O
myo-inositol + phosphate
-
-
-
-
?
myo-inositol 5-phosphate + H2O
myo-inositol + phosphate
-
myo-inositol 5-phosphate forms an electrostatic interaction between the metal ions and phosphate moiety, and the 2-OH group forms a hydrogen bond with the carbonyl group of Gln224, the 3-OH with the nitrogen atom of side chain of Gln224, and 4-OH with Asp231. The non-bridging oxygen O9 interacts with the 4-OH group, and the bridging oxygen O1 with Mg2+-2
-
-
?
myo-inositol 6-phosphate + H2O
myo-inositol + phosphate
-
-
-
-
?
myo-inositol 6-phosphate + H2O
myo-inositol + phosphate
-
the substrate shows a similar binding structure as inositol 5-phosphate
-
-
?
additional information
?
-
-
the enzyme is involved in development of bipolar disorder
-
-
?
additional information
?
-
-
substrate binding structure of IMPA2, docking study on other myo-inositol monophosphates, overview. Common binding patterns: the non-bridging oxygen atom O9 coordinated Mg2+-3 and O8 coordinated both Mg2+-1 and Mg2+-2. The bridging oxygen atom coordinated Mg2+-2. No activity with inositol 2-phosphate
-
-
?
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Alzheimer Disease
Alteration of myo-inositol monophosphatase in Alzheimer's disease brains.
Arthritis
Immune myopathies with perimysial pathology: Clinical and laboratory features.
Breast Neoplasms
A novel oncogenic role of inositol phosphatase SHIP2 in ER-negative breast cancer stem cells: involvement of JNK/vimentin activation.
Breast Neoplasms
Regulation of PtdIns(3,4,5)P3/Akt signalling by inositol polyphosphate 5-phosphatases.
Carcinoma
A novel function of IMPA2, plays a tumor-promoting role in cervical cancer.
Carcinoma
Conserved synteny between the Fugu and human PTEN locus and the evolutionary conservation of vertebrate PTEN function.
Carcinoma
Decreased cyclic inositol phosphohydrolase activity in hamster renal tumors and human renal cell carcinomas.
Carcinoma
IMPA2 Downregulation Enhances mTORC1 Activity and Restrains Autophagy Initiation in Metastatic Clear Cell Renal Cell Carcinoma.
Carcinoma in Situ
A novel function of IMPA2, plays a tumor-promoting role in cervical cancer.
Carcinoma, Renal Cell
Decreased cyclic inositol phosphohydrolase activity in hamster renal tumors and human renal cell carcinomas.
Carcinoma, Renal Cell
IMPA2 Downregulation Enhances mTORC1 Activity and Restrains Autophagy Initiation in Metastatic Clear Cell Renal Cell Carcinoma.
Cardiomegaly
Inpp5f Is a Polyphosphoinositide Phosphatase That Regulates Cardiac Hypertrophic Responsiveness.
Cardiomyopathies
[Evolution and thromboembolic complications of the idiopathic peripartal cardiomyopathy at Dakar University Hospital: forward-looking study about 33 cases].
Cardiovascular Diseases
[Treatment of erectile dysfunction in patients with ischemic heart disease and angina of effort]
Chronic Periodontitis
Upregulation of immunoregulatory Src homology 2 molecule containing inositol phosphatase and mononuclear cell hyporesponsiveness in oral mucosa during chronic periodontitis.
Dementia
Inositol monophosphatase activity in normal, Down syndrome and dementia of the Alzheimer type CSF.
Dementia, Multi-Infarct
Inositol monophosphatase activity in normal, Down syndrome and dementia of the Alzheimer type CSF.
Dermatomyositis
Immune myopathies with perimysial pathology: Clinical and laboratory features.
Diabetes Mellitus, Type 2
Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f negative feedback loop in the diabetic heart.
Diabetes, Gestational
Placental Inositol Reduced in Gestational Diabetes as Glucose Alters Inositol Transporters and IMPA1 Enzyme Expression.
Diabetic Cardiomyopathies
Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f negative feedback loop in the diabetic heart.
Down Syndrome
Inositol monophosphatase activity in normal, Down syndrome and dementia of the Alzheimer type CSF.
Drug Resistant Epilepsy
Inositol phosphatase INPP4A inhibits the apoptosis of in vitro neurons with characteristic of intractable epilepsy by reducing intracellular Ca2+ concentration.
Epilepsy
Impaired neuronal activity and differential gene expression in STXBP1 encephalopathy patient iPSC-derived GABAergic neurons.
Erectile Dysfunction
[An open non-comparative study of impase for treating erectile dysfunction]
Erectile Dysfunction
[Correction of erectile dysfunction in patients with chronic abacterial prostatitis].
Erectile Dysfunction
[Impase in the treatment of erectile dysfunction]
Erectile Dysfunction
[Treatment of erectile dysfunction in patients with ischemic heart disease and angina of effort]
Erectile Dysfunction
[Use of impase in the therapy of erectile dysfunction]
Erectile Dysfunction
[Viagra, cialis, impase--which of them, to whom, when and how?]
Galactosemias
Expression of human inositol monophosphatase suppresses galactose toxicity in Saccharomyces cerevisiae: possible implications in galactosemia.
Glioblastoma
Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity.
Glioma
Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity.
Glioma
Lithium inhibits invasion of glioma cells; possible involvement of glycogen synthase kinase-3.
Heart Defects, Congenital
Imprinting aberrations of SNRPN, ZAC1 and INPP5F genes involved in the pathogenesis of congenital heart disease with extracardiac malformations.
Hepatitis, Alcoholic
Antioxidant and hepatoprotective effects of intracellular mycelium polysaccharides from Pleurotus geesteranus against alcoholic liver diseases.
Huntington Disease
Potential protective effects of autophagy activated in MPP+ treated astrocytes.
Hyperglycemia
Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f negative feedback loop in the diabetic heart.
Hyperlipidemias
Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f negative feedback loop in the diabetic heart.
Hypertension, Pulmonary
Inositol monophosphatase 1 as a novel interacting partner of RAGE in pulmonary hypertension.
Infections
Effects of the deletion and over-expression of Fusarium graminearum gene FgHal2 on host response to mycovirus Fusarium graminearum virus 1.
Infections
Macrophage pro-inflammatory response to Francisella novicida infection is regulated by SHIP.
Infections
The inositol phosphatase SHIP controls Salmonella enterica serovar Typhimurium infection in vivo.
inositol-phosphate phosphatase deficiency
Inositol monophosphatase 1 (IMPA1) mutation in intellectual disability patients impairs neurogenesis but not gliogenesis.
Intellectual Disability
A homozygous loss-of-function mutation in inositol monophosphatase 1 (IMPA1) causes severe intellectual disability.
Intellectual Disability
Inositol monophosphatase 1 (IMPA1) mutation in intellectual disability patients impairs neurogenesis but not gliogenesis.
Intellectual Disability
Loss-of-function mutation in inositol monophosphatase 1 (IMPA1) results in abnormal synchrony in resting-state EEG.
Ischemic Stroke
IMPA2 polymorphisms and risk of ischemic stroke in a northwest Han Chinese population.
Leukemia, Lymphocytic, Chronic, B-Cell
Gene expression of INPP5F as an independent prognostic marker in fludarabine-based therapy of chronic lymphocytic leukemia.
Lung Diseases, Interstitial
Immune myopathies with perimysial pathology: Clinical and laboratory features.
Lung Neoplasms
Increased expression of insulin-like growth factor-II messenger RNA-binding protein 1 is associated with tumor progression in patients with lung cancer.
Malnutrition
Effects of neonatal undernutrition and subsequent nutritional rehabilitation or administration of thyroxine and hydrocortisone on the inositol phosphatase activities in rat intestine.
Malnutrition
Effects of postweaning protein malnutrition on intestinal inositol phosphatase activities in normally weaned and neonatally undernourished rats.
Mania
Inositol deficiency diet and lithium effects.
Melanoma
Regulation of PtdIns(3,4,5)P3/Akt signalling by inositol polyphosphate 5-phosphatases.
Muscular Diseases
Immune myopathies with perimysial pathology: Clinical and laboratory features.
Muscular Dystrophies
Fine mapping of the muscular dystrophy (AM) gene on chicken chromosome 2q.
Neoplasm Metastasis
A novel function of IMPA2, plays a tumor-promoting role in cervical cancer.
Neoplasm Metastasis
Dysregulation of the miR-25-IMPA2 axis promotes metastatic progression in clear cell renal cell carcinoma.
Neoplasms
A novel function of IMPA2, plays a tumor-promoting role in cervical cancer.
Neoplasms
Decreased cyclic inositol phosphohydrolase activity in hamster renal tumors and human renal cell carcinomas.
Neoplasms
Dysregulation of the miR-25-IMPA2 axis promotes metastatic progression in clear cell renal cell carcinoma.
Neoplasms
Increased expression of insulin-like growth factor-II messenger RNA-binding protein 1 is associated with tumor progression in patients with lung cancer.
Neoplasms
Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN.
Neoplasms
Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity.
Neoplasms
Overexpression of miR-155 causes expansion, arrest in terminal differentiation and functional activation of mouse natural killer cells.
Neoplasms
Predicting which children are at risk for ependymoma relapse.
Neoplasms
Regulation of PtdIns(3,4,5)P3/Akt signalling by inositol polyphosphate 5-phosphatases.
Neuralgia
Effect of HDAC2/Inpp5f on neuropathic pain and cognitive function through regulating PI3K/Akt/GSK-3? signal pathway in rats with neuropathic pain.
Neuralgia
Pregabalin on Hdac2 and Inpp5f levels in rats with CCI-induced neuropathic pain.
Neuroblastoma
Beryllium competitively inhibits brain myo-inositol monophosphatase, but unlike lithium does not enhance agonist-induced inositol phosphate accumulation.
Neurodegenerative Diseases
Potential protective effects of autophagy activated in MPP+ treated astrocytes.
Obesity
An investigation of obesity susceptibility genes in Northern Han Chinese by targeted resequencing.
Oculocerebrorenal Syndrome
IPIP27 Coordinates PtdIns(4,5)P2 Homeostasis for Successful Cytokinesis.
Parkinson Disease
Association of four new candidate genetic variants with Parkinson's disease in a Han Chinese population.
Raynaud Disease
Immune myopathies with perimysial pathology: Clinical and laboratory features.
Seizures
Effects of the putative lithium mimetic ebselen on pilocarpine-induced neural activity.
Seizures
Hippocampal transcriptional and neurogenic changes evoked by combination yohimbine and imipramine treatment.
Seizures
IMPA1 is essential for embryonic development and lithium-like pilocarpine sensitivity.
Seizures
Inositol-deficient food augments a behavioral effect of long-term lithium treatment mediated by inositol monophosphatase inhibition: an animal model with relevance for bipolar disorder.
Seizures
Intracerebroventricular antisense to inositol monophosphatase-1 reduces enzyme activity but does not affect Li-sensitive behavior.
Seizures
Modulation of phosphatidylinositol turnover on central nicotinic receptors.
Seizures
The inositol monophosphatase inhibitor L-690,330 affects pilocarpine-behavior and the forced swim test.
Seizures
Ziskind-Somerfeld Research Award 1993. Biochemical, behavioral, and clinical studies of the role of inositol in lithium treatment and depression.
Seizures, Febrile
Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures.
Seizures, Febrile
Genetic variants in the IMPA2 gene do not confer increased risk of febrile seizures in Caucasian patients.
Seizures, Febrile
Linkage and association of febrile seizures to the IMPA2 gene on human chromosome 18.
Seizures, Febrile
Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1.
Spinal Cord Injuries
Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury.
Spinocerebellar Ataxias
Bergmann glial S100B activates myo-inositol monophosphatase 1 and Co-localizes to purkinje cell vacuoles in SCA1 transgenic mice.
Thrombosis
[Evolution and thromboembolic complications of the idiopathic peripartal cardiomyopathy at Dakar University Hospital: forward-looking study about 33 cases].
Tuberculosis
Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+
Tuberculosis
Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis.
Tuberculosis
Purification and biochemical characterization of Mycobacterium tuberculosis SuhB, an inositol monophosphatase involved in inositol biosynthesis.
Uterine Cervical Neoplasms
A novel function of IMPA2, plays a tumor-promoting role in cervical cancer.
Virus Diseases
Impaired B cell function during viral infections due to PTEN-mediated inhibition of the PI3K pathway.
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Creba, J.A.; Carey, F.; McCulloch, A.
Metabolism of inositol 1-phosphate in HL60 cells
Biochem. Soc. Trans.
16
557-558
1988
Homo sapiens
-
brenda
Huang, E.M.; Detwiler, T.C.
The effects of lithium on platelet phosphoinositide metabolism
Biochem. J.
236
895-901
1986
Homo sapiens
brenda
Conolly, T.M.; Wilson, D.B.; Bross, T.E.; Majerus, P.W.
Isolation and characterization of the inositol cyclic phosphate products of phosphoinositide cleavage by phospholipase C
J. Biol. Chem.
261
122-126
1986
Homo sapiens, Rattus norvegicus
brenda
McAllister, G.; Whiting, P.; Hammond, E.A.; Knowles, M.R.; Atack, J.R.; Bailey, F.J.; Maigetter, R.; Ragan, C.I.
cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme
Biochem. J.
284
749-754
1992
Bos taurus, Homo sapiens, Rattus norvegicus
brenda
Vincendon, P.; Corti, E.; Guindani, A.; Brunati, C.; Sponga, F.; Stefanelli, S.; Denaro, M.; Pelton, P.; Ganzhorn, A.; Islam, K.
An automated high volume assay to screen for inhibitors of myo-inositol monophosphatase from microbial fermentation broths
J. Antibiot.
49
710-712
1996
Homo sapiens
brenda
Atack, J.R.; Rapoport, S.I.; Varley, C.L.;
Characterization of inositol monophosphatase in human cerebrospinal fluid
Brain Res.
613
305-308
1993
Homo sapiens
brenda
Parthasarathy, L.; Vadnal, R.E.; Parthasarathy, R.; Shyamaldevi, C.S.
Minireview. Biochemical and molecular properties of lithium-sensitive myo-inositol monophosphatase
Life Sci.
54
1127-1142
1994
Bos taurus, Homo sapiens, Lilium longiflorum, Rattus norvegicus
brenda
Zheng, W.; Brandish, P.E.; Kolodin, D.G.; Scolnick, E.M.; Strulovici, B.
High-throughput cell-based screening using scintillation proximity assay for the discovery of inositol phosphatase inhibitors
J. Biomol. Screen.
9
132-140
2004
Homo sapiens
brenda
Miller, D.J.; Allemann, R.K.
myo-inositol monophosphatase: a challenging target for mood stabilising drugs
Mini Rev. Med. Chem.
7
107-113
2007
Homo sapiens
brenda
Arai, R.; Ito, K.; Ohnishi, T.; Ohba, H.; Akasaka, R.; Bessho, Y.; Hanawa-Suetsugu, K.; Yoshikawa, T.; Shirouzu, M.; Yokoyama, S.
Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures
Proteins
67
732-742
2007
Homo sapiens
brenda
Fujita, S.; Ohnishi, T.; Okuda, S.; Kobayashi, R.; Fukuno, S.; Furuta, D.; Kikuchi, T.; Yoshikawa, T.; Fujita, N.
In silico study on the substrate binding manner in human myo-inositol monophosphatase 2
J. Mol. Model.
17
2559-2567
2011
Homo sapiens
brenda
Singh, N.; Halliday, A.C.; Knight, M.; Lack, N.A.; Lowe, E.; Churchill, G.C.
Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens
Acta Crystallogr. Sect. F
68
1149-1152
2012
Mus musculus (O55023), Mus musculus, Homo sapiens (P29218), Homo sapiens
brenda
Kraft, L.; Roe, S.M.; Gill, R.; Atack, J.R.
Co-crystallization of human inositol monophosphatase with the lithium mimetic L-690,330
Acta Crystallogr. Sect. D
74
973-978
2018
Homo sapiens (P29218), Homo sapiens
brenda
Agam, G.; Almog, O.
Calbindin D28k and S100B have a similar interaction site with the lithium-inhibitable enzyme inositol monophosphatase-1 a new drug target site
J. Med. Chem.
58
2042-2044
2015
Homo sapiens (P05937)
brenda
Figueiredo, T.; Melo, U.S.; Pessoa, A.L.; Nobrega, P.R.; Kitajima, J.P.; Rusch, H.; Vaz, F.; Lucato, L.T.; Zatz, M.; Kok, F.; Santos, S.
A homozygous loss-of-function mutation in inositol monophosphatase 1 (IMPA1) causes severe intellectual disability
Mol. Psychiatry
21
1125-1129
2016
Homo sapiens (P29218), Homo sapiens
brenda
Ferruz, N.; Tresadern, G.; Pineda-Lucena, A.; De Fabritiis, G.
Multibody cofactor and substrate molecular recognition in the myo-inositol monophosphatase enzyme
Sci. Rep.
6
30275
2016
Homo sapiens (P29218)
brenda