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EC Tree
IUBMB Comments A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48 protein-tyrosine-phosphatase). The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1, phosphoamidase).
The taxonomic range for the selected organisms is: Dictyostelium discoideum The enzyme appears in selected viruses and cellular organisms
Synonyms
calcineurin, protein phosphatase, pac-1, dusp1, dusp6, serine/threonine phosphatase, pp2ac, ppm1d, phosphoprotein phosphatase, laforin,
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3-hydroxy 3-methylglutaryl CoenzymeA reductase phosphatase
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Aspergillus awamori acid protein phosphatase
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BCKDH phosphatase
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branched-chain alpha-keto acid dehydrogenase phosphatase
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CaM-kinase phosphatase
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casein phosphatase
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Fibroblast growth factor inducible protein 13
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Flap wing protein
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HMG-CoA reductase phosphatase
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Magnesium-dependent calcium inhibitable phosphatase
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Microtubule star protein
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phosphoprotein phosphatase
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phosphopyruvate dehydrogenase phosphatase
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phosphospectrin phosphatase
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polycation modulated (PCM-) phosphatase
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protein D phosphatase
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protein phosphatase
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Protein phosphatase 1A
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Protein phosphatase 1B
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Protein phosphatase 1C
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Protein phosphatase magnesium-dependent 1 delta
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Protein phosphatase magnesium-dependent 1 gamma
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Protein phosphatase with EF calcium-binding domain
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Retinal degeneration C protein
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Suppressor protein SDS21
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hydrolysis of phosphoric ester
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protein-serine/threonine-phosphate phosphohydrolase
A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48 protein-tyrosine-phosphatase). The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1, phosphoamidase).
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phosphoproteins + H2O
proteins + phosphate
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p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
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phosphocasein + H2O
casein + phosphate
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phosphoproteins + H2O
proteins + phosphate
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phosphorylated phosphorylase alpha + H2O
phosphorylase alpha + phosphate
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Ca2+
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calcineurin A, strictly dependent on Mn2+ or Mg2+ or Ca2+
Mg2+
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calcineurin A, strictly dependent on Mn2+ or Mg2+ or Ca2+
Mn2+
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calcineurin A, strictly dependent on Mn2+ or Mg2+ or Ca2+
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7.8
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Mn2+-stimulated calcineurin A
8.3
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Mg2+-stimulated calcineurin A
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Uniprot
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B-subunit of phosphatase PP2A
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A-subunit of phosphatase PP2A
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PP2AA_DICDI
306
0
35186
Swiss-Prot
other Location (Reliability: 1 )
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37000
phosphatase PP2A, catalytic subunit C, regulatory subunits A and B, 1 * 37000 + 1 * 65000 + 1 * 55000
55000
phosphatase PP2A, catalytic subunit C, regulatory subunits A and B, 1 * 37000 + 1 * 65000 + 1 * 55000
65000
phosphatase PP2A, catalytic subunit C, regulatory subunits A and B, 1 * 37000 + 1 * 65000 + 1 * 55000
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trimer
phosphatase PP2A, catalytic subunit C, regulatory subunits A and B, 1 * 37000 + 1 * 65000 + 1 * 55000
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F269C
increased enzyme activity against phosphorylase alpha and a higher sensitivity to calculin A
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overexpression in Dictyostelium discoideum
expression in Escherichia coli
overexpression in Dictyostelium discoideum
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Hellstern, S.; Dammann, H.; Husain, Q.; Mutzel, R.
Overexpression, purification and characterization of Dictyostelium calcineurin A
Res. Microbiol.
148
335-343
1997
Dictyostelium discoideum
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Murphy, M.B.; Levi, S.K.; Egelhoff, T.T.
Molecular characterization and immunolocalization of Dictyostelium discoideum protein phosphatase 2A
FEBS Lett.
456
7-12
1999
Dictyostelium discoideum (Q9XZE5)
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Andrioli, L.P.; Zaini, P.A.; Viviani, W.; Da Silva, A.M.
Dictyostelium discoideum protein phosphatase-1 catalytic subunit exhibits distinct biochemical properties
Biochem. J.
373
703-711
2003
Dictyostelium discoideum (O15757)
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