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Information on EC 3.1.3.16 - protein-serine/threonine phosphatase and Organism(s) Dictyostelium discoideum and UniProt Accession O15757

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.16 protein-serine/threonine phosphatase
IUBMB Comments
A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48 protein-tyrosine-phosphatase). The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1, phosphoamidase).
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Dictyostelium discoideum
UNIPROT: O15757
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The taxonomic range for the selected organisms is: Dictyostelium discoideum
The enzyme appears in selected viruses and cellular organisms
Synonyms
calcineurin, protein phosphatase, pac-1, dusp1, dusp6, serine/threonine phosphatase, pp2ac, ppm1d, phosphoprotein phosphatase, laforin, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3-hydroxy 3-methylglutaryl CoenzymeA reductase phosphatase
-
-
-
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Aspergillus awamori acid protein phosphatase
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-
-
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BCKDH phosphatase
-
-
-
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branched-chain alpha-keto acid dehydrogenase phosphatase
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-
-
-
calcineurin
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-
-
-
Calcineurin A1
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-
-
-
Calcineurin A2
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-
-
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CaM-kinase phosphatase
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-
-
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CaMKPase
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-
-
-
casein phosphatase
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-
-
-
DRES10
-
-
-
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Fibroblast growth factor inducible protein 13
-
-
-
-
FIN13
-
-
-
-
Flap wing protein
-
-
-
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HMG-CoA reductase phosphatase
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-
-
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Magnesium-dependent calcium inhibitable phosphatase
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-
-
-
MCPP
-
-
-
-
Microtubule star protein
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-
-
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phosphatase 2A
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-
-
-
phosphatase 2B
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-
-
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phosphatase C-II
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-
-
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Phosphatase esp1
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-
-
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phosphatase H-II
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-
-
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phosphatase I
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-
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phosphatase IB
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-
-
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phosphatase II
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-
-
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phosphatase III
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-
-
-
phosphatase IV
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-
-
-
phosphatase SP
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-
-
-
phosphoprotein phosphatase
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-
-
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phosphopyruvate dehydrogenase phosphatase
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-
-
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phosphospectrin phosphatase
-
-
-
-
PK-Pase
-
-
-
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polycation modulated (PCM-) phosphatase
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-
-
-
PP-1A
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-
-
-
PP-1B
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-
-
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PP-1G
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-
-
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PP2A-alpha
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-
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PP2A-beta
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-
-
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PP2C
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-
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PP2C-alpha
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-
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PP2C-beta
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-
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PP2C-delta
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-
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PP2C-gamma
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-
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Pp4
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-
-
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PP5
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-
-
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PP6
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-
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PPEF
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-
-
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PPN
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-
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PPT
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-
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protein D phosphatase
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-
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protein phosphatase
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-
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Protein phosphatase 1A
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-
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Protein phosphatase 1B
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-
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Protein phosphatase 1C
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-
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Protein phosphatase magnesium-dependent 1 delta
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-
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Protein phosphatase magnesium-dependent 1 gamma
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-
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Protein phosphatase with EF calcium-binding domain
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PSPase
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Retinal degeneration C protein
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Suppressor protein SDS21
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
protein-serine/threonine-phosphate phosphohydrolase
A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48 protein-tyrosine-phosphatase). The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1, phosphoamidase).
CAS REGISTRY NUMBER
COMMENTARY hide
9025-75-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
phosphorylated phosphorylase alpha + H2O
phosphorylase alpha + phosphate
show the reaction diagram
-
-
-
?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
show the reaction diagram
-
-
-
-
?
phosphocasein + H2O
casein + phosphate
show the reaction diagram
-
-
-
-
?
phosphoproteins + H2O
proteins + phosphate
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
-
calcineurin A, strictly dependent on Mn2+ or Mg2+ or Ca2+
Mg2+
-
calcineurin A, strictly dependent on Mn2+ or Mg2+ or Ca2+
Mn2+
-
calcineurin A, strictly dependent on Mn2+ or Mg2+ or Ca2+
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.8
-
Mn2+-stimulated calcineurin A
8.3
-
Mg2+-stimulated calcineurin A
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
B-subunit of phosphatase PP2A
Manually annotated by BRENDA team
A-subunit of phosphatase PP2A
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PP1_DICDI
321
0
36939
Swiss-Prot
other Location (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37000
phosphatase PP2A, catalytic subunit C, regulatory subunits A and B, 1 * 37000 + 1 * 65000 + 1 * 55000
55000
phosphatase PP2A, catalytic subunit C, regulatory subunits A and B, 1 * 37000 + 1 * 65000 + 1 * 55000
65000
phosphatase PP2A, catalytic subunit C, regulatory subunits A and B, 1 * 37000 + 1 * 65000 + 1 * 55000
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
trimer
phosphatase PP2A, catalytic subunit C, regulatory subunits A and B, 1 * 37000 + 1 * 65000 + 1 * 55000
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
F269C
increased enzyme activity against phosphorylase alpha and a higher sensitivity to calculin A
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
overexpression in Dictyostelium discoideum
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hellstern, S.; Dammann, H.; Husain, Q.; Mutzel, R.
Overexpression, purification and characterization of Dictyostelium calcineurin A
Res. Microbiol.
148
335-343
1997
Dictyostelium discoideum
Manually annotated by BRENDA team
Murphy, M.B.; Levi, S.K.; Egelhoff, T.T.
Molecular characterization and immunolocalization of Dictyostelium discoideum protein phosphatase 2A
FEBS Lett.
456
7-12
1999
Dictyostelium discoideum (Q9XZE5)
Manually annotated by BRENDA team
Andrioli, L.P.; Zaini, P.A.; Viviani, W.; Da Silva, A.M.
Dictyostelium discoideum protein phosphatase-1 catalytic subunit exhibits distinct biochemical properties
Biochem. J.
373
703-711
2003
Dictyostelium discoideum (O15757)
Manually annotated by BRENDA team