Reference on EC 3.1.26.3 - ribonuclease III
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chen, S.M.; Takiff, H.E.; Barber, A.M.; Dubois, G.C.; Bardwell, J.C.A.; Court, D.L.
Expression and characterization of RNase III and Era proteins. Products of the rnc operon of Escherichia coli
J. Biol. Chem.
265
2888-2895
1990
Escherichia coli
Nicholson, A.W.; Niebling, K.R.; McOsker, P.L.; Robertson, H.D.
Accurate in vitro cleavage by RNase III of phosphorothioate-substituted RNA processing signals in bacteriophage T7 early mRNA
Nucleic Acids Res.
16
1577-1591
1988
Escherichia coli
Gross, G.; Dunn, J.J.
Structure of secondary cleavage sites of E. coli RNAaseIII in A3t RNA from bacteriophage T7
Nucleic Acids Res.
15
431-442
1987
Escherichia coli
Gurevitz, M.; Apirion, D.
The ribonuclease-III-processing site near the 5 end of an RNA precursor of bacteriophage T4 and its effect on termination
Eur. J. Biochem.
147
581-586
1985
Escherichia coli
Watson, N.; Apirion, D.
Molecular cloning of the gene for the RNA-processing enzyme RNase III of Escherichia coli
Proc. Natl. Acad. Sci. USA
82
849-853
1985
Escherichia coli
Szeberenyi, J.; Roy, M.K.; Vaidya, H.C.; Apirion, D.
7S RNA, containing 5S ribosomal RNA and the termination stem, is a specific substrate for the two RNA processing enzymes RNase III and RNase E
Biochemistry
23
2952-2957
1984
Escherichia coli
King, T.C.; Sirdeshmukh, R.; Schlessinger, D.
RNase III cleavage is obligate for maturation but not for function of Escherichia coli pre-23S rRNA
Proc. Natl. Acad. Sci. USA
81
185-188
1984
Escherichia coli
Panganiban, A.T.; Whiteley, H.R.
Bacillus subtilis RNAase III cleavage sites in phage SP82 early mRNA
Cell
33
907-913
1983
Bacillus subtilis, Escherichia coli
Barkay, T.; Goldfarb, A.
Processing of bacteriophage T4 primary transcripts with ribonuclease III
J. Mol. Biol.
162
299-315
1982
Escherichia coli
Dunn, J.J
Ribonuclease III
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
15
485-499
1982
Bos taurus, Escherichia coli, Homo sapiens, Mus musculus
-
Rech, J.; Cathala, G.; Jeanteur, P.
Isolation and characterization of a ribonuclease activity specific for double-stranded RNA (RNase D) from Krebs II ascites cells
J. Biol. Chem.
255
6700-6705
1980
Mus musculus
Birenbaum, M.; Shen, V.; Nikolaev, N.; Schlessinger, D.
Site-specific processing of Escherichia coli preribosomal RNA and preribosomes by E. coli RNase III
Methods Enzymol.
59
824-837
1979
Escherichia coli
Shimura, Y.; Sakano, H.; Nagawa, F.
Specific ribonucleases involved in processing of tRNA precursors of Escherichia coli. Partial purification and some properties
Eur. J. Biochem.
86
267-281
1978
Escherichia coli
Rech, J.; Cathala, G.; Jeanteur, P.
Partial purification of a double-stranded RNA specific ribonuclease (RNAse D) from Krebs II ascites cells
Nucleic Acids Res.
3
2055-2065
1976
Mus musculus
Dunn, J.J.
RNase III cleavage of single-stranded RNA. Effect of ionic strength on the fideltiy of cleavage
J. Biol. Chem.
251
3807-3814
1976
Escherichia coli
Paddock, G.V.; Fukada, K.; Abelson, J.; Robertson, H.D.
Cleavage of T4 species I ribonucleic acid by Escherichia coli ribonuclease III
Nucleic Acids Res.
3
1351-1371
1976
Escherichia coli
Suryanarayana, T.; Burma, D.P.
Substrate specificity of Salmonella typhimurium RNAase III and the nature of products formed
Biochim. Biophys. Acta
407
459-468
1975
Salmonella enterica subsp. enterica serovar Typhimurium
Crouch, R.J.
Ribonuclease 3 does not degrade deoxyribonucleic acid-ribonucleic acid hybrids
J. Biol. Chem.
249
1314-1316
1974
Escherichia coli
Robertson, H.D.; Webster, R.E.; Zinder, N.D.
Purification and properties of ribonuclease III from Escherichia coli
J. Biol. Chem.
243
82-91
1968
Escherichia coli
Zhang, J.R.; Deutscher, M.P.
Analysis of the upstream region of the Escherichia coli rnd gene encoding RNase D. Evidence for translational regulation of a putative tRNA processing enzyme
J. Biol. Chem.
264
18228-18233
1989
Escherichia coli
Srivastava, R.A.; Srivastava, N.; Apirion, D.
RNA processing enzymes RNase III, E and P in Escherichia coli are not ribosomal enzymes
Biochem. Int.
25
57-65
1991
Escherichia coli
Ben-Artzi, H.; Zeelon, E.; Gorecki, M.; Panet, A.
Double-stranded RNA-dependent RNase activity associated with human immunodeficiency virus type 1 reverse transcriptase
Proc. Natl. Acad. Sci. USA
89
927-931
1992
Homo sapiens
Hostomsky, Z.; Hudson, G.O.; Rahmati, S.; Hostomska, Z.
RNase D, a reported new activity associated with HIV-1 reverse transcriptase, displays the same cleavage specificity as Escherichia coli RNase III
Nucleic Acids Res.
20
5819-5824
1992
Homo sapiens
Srivastava, R.A.; Srivastava, N.; Apirion, D.
Characterization of the RNA processing enzyme RNase III from wild type and overexpressing Escherichia coli cells in processing natural RNA substrates
Int. J. Biochem.
24
737-749
1992
Escherichia coli
Li, H.L.; Chelladurai, B.S.; Zhang, K.; Nicholson, A.W.
Ribonuclease III cleavage of a bacteriophage T7 processing signal. Divalent cation specificity, and specific anion effects
Nucleic Acids Res.
21
1919-1925
1993
Escherichia coli
Davidov, Y.; Rahat, A.; Flechner, I.; Pines, O.
Characterization of the rnc-97 mutation of RNAaseIII: a glycine to glutamate substitution increases the requirement for magnesium ions
J. Gen. Microbiol.
139
717-724
1993
Escherichia coli
Srivastava, R.A.; Srivastava, N.
The multifaceted roles of the RNA processing enzyme ribonuclease III
Indian J. Biochem. Biophys.
33
253-260
1996
Escherichia coli, Rattus norvegicus
Srivastava, N.; Srivastava, R.A.
Expression, purification and properties of recombinant E. coli ribonuclease III
Biochem. Mol. Biol. Int.
39
171-180
1996
Escherichia coli
Zhang, K.; Nicholson, A.W.
Regulation of ribonuclease III processing by double-helical sequence antideterminants
Proc. Natl. Acad. Sci. USA
94
13437-13441
1997
Escherichia coli
Oguro, A.; Kakeshita, H.; Nakamura, K.; Yamane, K.; Wang, W.; Bechhofer, D.H.
Bacillus subtilis RNase III cleaves both 5'- and 3'-sites of the small cytoplasmic RNA precursor
J. Biol. Chem.
273
19542-19547
1998
Bacillus subtilis, Saccharomyces cerevisiae, Schizosaccharomyces pombe
Conrad, C.; Rauhut, R.; Klug, G.
Different cleavage specificities of RNases III from Rhodobacter capsulatus and Escherichia coli
Nucleic Acids Res.
26
4446-4453
1998
Escherichia coli, Rhodobacter capsulatus
Binnie, U.; Wong, K.; McAteer, S.; Masters, M.
Absence of RNASE III alters the pathway by which RNAI, the antisense inhibitor of ColE1 replication, decays
Microbiology
145
3089-3100
1999
Escherichia coli
Sun, W.; Nicholson, A.W.
Mechanism of action of Escherichia coli ribonuclease III. Stringent chemical requirement for the glutamic acid 117 side chain and Mn2+ rescue of the Glu117Asp mutant
Biochemistry
40
5102-5110
2001
Escherichia coli
De Gregorio, E.; Abrescia, C.; Carlomagno, M.S.; Di Nocera, P.P.
Ribonuclease III-mediated processing of specific Neisseria meningitidis mRNAs
Biochem. J.
374
799-805
2003
Neisseria meningitidis
Sun, W.; Jun, E.; Nicholson, A.W.
Intrinsic double-stranded-RNA processing activity of Escherichia coli ribonuclease III lacking the dsRNA-binding domain
Biochemistry
40
14976-14984
2001
Escherichia coli
Calin-Jageman, I.; Nicholson, A.W.
Mutational analysis of an RNA internal loop as a reactivity epitope for Escherichia coli ribonuclease III substrates
Biochemistry
42
5025-5034
2003
Escherichia coli
Chanfreau, G.
Conservation of RNase III processing pathways and specificity in hemiascomycetes
Eukaryot. Cell
2
901-909
2003
Saccharomyces cerevisiae, Millerozyma farinosa, Debaryomyces hansenii, Kluyveromyces marxianus, Yarrowia lipolytica, Candida tropicalis, Ogataea angusta, Kluyveromyces lactis, Saccharomyces bayanus, Zygosaccharomyces rouxii, Lachancea thermotolerans, Lachancea kluyveri, Kazachstania exigua, Kazachstania servazzii
Conrad, C.; Evguenieva-Hackenberg, E.; Klug, G.
Both N-terminal catalytic and C-terminal RNA binding domain contribute to substrate specificity and cleavage site selection of RNase III
FEBS Lett.
509
53-58
2001
Escherichia coli, Rhodobacter capsulatus
Conrad, C.; Schmitt, J.G.; Evguenieva-Hackenberg, E.; Klug, G.
One functional subunit is sufficient for catalytic activity and substrate specificity of Escherichia coli endoribonuclease III artificial heterodimers
FEBS Lett.
518
93-96
2002
Escherichia coli
Lamontagne, B.; Ghazal, G.; Lebars, I.; Yoshizawa, S.; Fourmy, D.; Abou Elela, S.
Sequence dependence of substrate recognition and cleavage by yeast RNase III
J. Mol. Biol.
327
985-1000
2003
Saccharomyces cerevisiae
Amarasinghe, A.K.; Calin-Jageman, I.; Harmouch, A.; Sun, W.; Nicholson, A.W.
Escherichia coli ribonuclease III: affinity purification of hexahistidine-tagged enzyme and assays for substrate binding and cleavage
Methods Enzymol.
342
143-158
2001
Escherichia coli
Zamore, P.D.
Thirty-three years later, a glimpse at the ribonuclease III active site
Mol. Cell
8
1158-1160
2001
Aquifex aeolicus, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Escherichia coli, Homo sapiens
Lamontagne, B.; Tremblay, A.; Elela, S.A.
The N-terminal domain that distinguishes yeast from bacterial RNase III contains a dimerization signal required for efficient double-stranded RNA cleavage
Mol. Cell. Biol.
20
1104-1115
2000
Saccharomyces cerevisiae
Calin-Jageman, I.; Amarasinghe, A.K.; Nicholson, A.W.
Ethidium-dependent uncoupling of substrate binding and cleavage by Escherichia coli ribonuclease III
Nucleic Acids Res.
29
1915-1925
2001
Escherichia coli
Calin-Jageman, I.; Nicholson, A.W.
RNA structure-dependent uncoupling of substrate recognition and cleavage by Escherichia coli ribonuclease III
Nucleic Acids Res.
31
2381-2392
2003
Escherichia coli
Nagel, R.; Ares, M.Jr.
Substrate recognition by a eukaryotic RNase III: the double-stranded RNA-binding domain of Rnt1p selectively binds RNA containing a 5'-AGNN-3' tetraloop
RNA
6
1142-1156
2000
Saccharomyces cerevisiae
Knight, S.W.; Bass, B.L.
A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans
Science
293
2269-2271
2001
Caenorhabditis elegans
Zhang, Y.; Calin-Jageman, I.; Gurnon, J.R.; Choi, T.J.; Adams, B.; Nicholson, A.W.; Van Etten, J.L.
Characterization of a chlorella virus PBCV-1 encoded ribonuclease III
Virology
317
73-83
2003
Paramecium bursaria Chlorella virus-1
Amblar, M.; Viegas, S.C.; Lopez, P.; Arraiano, C.M.
Homologous and heterologous expression of RNase III from Lactococcus lactis
Biochem. Biophys. Res. Commun.
323
884-890
2004
Lactococcus lactis
Sun, W.; Li, G.; Nicholson, A.W.
Mutational analysis of the nuclease domain of Escherichia coli ribonuclease III. Identification of conserved acidic residues that are important for catalytic function in vitro
Biochemistry
43
13054-13062
2004
Escherichia coli
Sam, M.; Henras, A.K.; Chanfreau, G.
A conserved major groove antideterminant for Saccharomyces cerevisiae RNase III recognition
Biochemistry
44
4181-4187
2005
Saccharomyces cerevisiae
Bhogal, R.K.; Mitchell, A.L.; Coen, C.W.
Identification of putative rat ribonuclease III by differential display: a novel rat mRNA expressed in a circadian manner in the rat suprachiasmatic nucleus
Brain Res. Mol. Brain Res.
131
51-57
2004
Rattus norvegicus (Q67B98)
Zhang, H.; Kolb, F.A.; Jaskiewicz, L.; Westhof, E.; Filipowicz, W.
Single processing center models for human Dicer and bacterial RNase III
Cell
118
57-68
2004
Escherichia coli, Homo sapiens
Gan, J.; Tropea, J.E.; Austin, B.P.; Court, D.L.; Waugh, D.S.; Ji, X.
Structural insight into the mechanism of double-stranded RNA processing by ribonuclease III
Cell
124
355-366
2006
Aquifex aeolicus
Leulliot, N.; Quevillon-Cheruel, S.; Graille, M.; van Tilbeurgh, H.; Leeper, T.C.; Godin, K.S.; Edwards, T.E.; Sigurdsson, S.T.; Rozenkrants, N.; Nagel, R.J.; Ares, M.; Varani, G.
A new alpha-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III
EMBO J.
23
2468-2477
2004
Saccharomyces cerevisiae (Q02555), Saccharomyces cerevisiae
Huntzinger, E.; Boisset, S.; Saveanu, C.; Benito, Y.; Geissmann, T.; Namane, A.; Lina, G.; Etienne, J.; Ehresmann, B.; Ehresmann, C.; Jacquier, A.; Vandenesch, F.; Romby, P.
Staphylococcus aureus RNAIII and the endoribonuclease III coordinately regulate spa gene expression
EMBO J.
24
824-835
2005
Staphylococcus aureus
Kreuze, J.F.; Savenkov, E.I.; Cuellar, W.; Li, X.; Valkonen, J.P.
Viral class 1 RNase III involved in suppression of RNA silencing
J. Virol.
79
7227-7238
2005
sweet potato chlorotic stunt virus
Sun, W.; Pertzev, A.; Nicholson, A.W.
Catalytic mechanism of Escherichia coli ribonuclease III: kinetic and inhibitor evidence for the involvement of two magnesium ions in RNA phosphodiester hydrolysis
Nucleic Acids Res.
33
807-815
2005
Escherichia coli
Wu, H.; Henras, A.; Chanfreau, G.; Feigon, J.
Structural basis for recognition of the AGNN tetraloop RNA fold by the double-stranded RNA-binding domain of Rnt1p RNase III
Proc. Natl. Acad. Sci. USA
101
8307-8312
2004
Saccharomyces cerevisiae (Q02555), Saccharomyces cerevisiae
Henras, A.K.; Sam, M.; Hiley, S.L.; Wu, H.; Hughes, T.R.; Feigon, J.; Chanfreau, G.F.
Biochemical and genomic analysis of substrate recognition by the double-stranded RNA binding domain of yeast RNase III
RNA
11
1225-1237
2005
Saccharomyces cerevisiae (Q02555), Saccharomyces cerevisiae
Gan, J.; Tropea, J.E.; Austin, B.P.; Court, D.L.; Waugh, D.S.; Ji, X.
Intermediate states of ribonuclease III in complex with double-stranded RNA
Structure
13
1435-1442
2005
Aquifex aeolicus (O67082)
Ji, X.
Structural basis for non-catalytic and catalytic activities of ribonuclease III
Acta Crystallogr. Sect. D
62
933-940
2006
Thermotoga maritima, Aquifex aeolicus (O67082), Escherichia coli (P0A7Y0), Saccharomyces cerevisiae (Q02555), Homo sapiens (Q9NRR4), Homo sapiens (Q9UPY3)
Takeshita, D.; Zenno, S.; Lee, W.C.; Nagata, K.; Saigo, K.; Tanokura, M.
Crystallization and preliminary X-ray analysis of the C-terminal RNase III domain of human Dicer
Acta Crystallogr. Sect. F
62
402-404
2006
Homo sapiens (Q9UPY3), Homo sapiens
Gaudin, C.; Ghazal, G.; Yoshizawa, S.; Elela, S.A.; Fourmy, D.
Structure of an AAGU tetraloop and its contribution to substrate selection by yeast RNase III
J. Mol. Biol.
363
322-331
2006
Saccharomyces cerevisiae
Ghazal, G.; Elela, S.A.
Characterization of the reactivity determinants of a novel hairpin substrate of yeast RNase III
J. Mol. Biol.
363
332-344
2006
Saccharomyces cerevisiae
Takeshita, D.; Zenno, S.; Lee, W.C.; Nagata, K.; Saigo, K.; Tanokura, M.
Homodimeric structure and double-stranded RNA cleavage activity of the C-terminal RNase III domain of human dicer
J. Mol. Biol.
374
106-120
2007
Homo sapiens (Q9UPY3), Homo sapiens
Viegas, S.C.; Pfeiffer, V.; Sittka, A.; Silva, I.J.; Vogel, J.; Arraiano, C.M.
Characterization of the role of ribonucleases in Salmonella small RNA decay
Nucleic Acids Res.
35
7651-7664
2007
Salmonella enterica
Comella, P.; Pontvianne, F.; Lahmy, S.; Vignols, F.; Barbezier, N.; Debures, A.; Jobet, E.; Brugidou, E.; Echeverria, M.; Saez-Vasquez, J.
Characterization of a ribonuclease III-like protein required for cleavage of the pre-rRNA in the 3ETS in Arabidopsis
Nucleic Acids Res.
36
1163-1175
2008
Arabidopsis thaliana
Du, Z.; Lee, J.K.; Tjhen, R.; Stroud, R.M.; James, T.L.
Structural and biochemical insights into the dicing mechanism of mouse Dicer: a conserved lysine is critical for dsRNA cleavage
Proc. Natl. Acad. Sci. USA
105
2391-2396
2008
Mus musculus (Q8R418), Mus musculus
MacRae, I.J.; Doudna, J.A.
Ribonuclease revisited: structural insights into ribonuclease III family enzymes
Curr. Opin. Struct. Biol.
17
138-145
2007
Aquifex aeolicus, Saccharomyces cerevisiae, Escherichia coli, Giardia intestinalis, Homo sapiens
Gan, J.; Shaw, G.; Tropea, J.E.; Waugh, D.S.; Court, D.L.; Ji, X.
A stepwise model for double-stranded RNA processing by ribonuclease III
Mol. Microbiol.
67
143-154
2008
Aquifex aeolicus (O67082)
Watkins, K.P.; Kroeger, T.S.; Cooke, A.M.; Williams-Carrier, R.E.; Friso, G.; Belcher, S.E.; van Wijk, K.J.; Barkan, A.
A ribonuclease III domain protein functions in group II intron splicing in maize chloroplasts
Plant Cell
19
2606-2623
2007
Zea mays (A6YSL1), Zea mays
Zenke, K.; Kim, K.H.
Functional characterization of the RNase III gene of rock bream iridovirus
Arch. Virol.
153
1651-1656
2008
Rock bream iridovirus (Q5YF04), Rock bream iridovirus, Rock bream iridovirus RBIV (Q5YF04)
Lavoie, M.; Abou Elela, S.
Yeast ribonuclease III uses a network of multiple hydrogen bonds for RNA binding and cleavage
Biochemistry
47
8514-8526
2008
Saccharomyces cerevisiae (Q02555), Saccharomyces cerevisiae
Dincbas-Renqvist, V.; Pepin, G.; Rakonjac, M.; Plante, I.; Ouellet, D.L.; Hermansson, A.; Goulet, I.; Doucet, J.; Samuelsson, B.; Radmark, O.; Provost, P.
Human Dicer C-terminus functions as a 5-lipoxygenase binding domain
Biochim. Biophys. Acta
1789
99-108
2009
Homo sapiens
Ji, X.
The mechanism of RNase III action: how dicer dices
Curr. Top. Microbiol. Immunol.
320
99-116
2008
Bacteria
Kim, K.S.; Manasherob, R.; Cohen, S.N.
YmdB: a stress-responsive ribonuclease-binding regulator of E. coli RNase III activity
Genes Dev.
22
3497-3508
2008
Escherichia coli
Sello, J.K.; Buttner, M.J.
The gene encoding RNase III in Streptomyces coelicolor is transcribed during exponential phase and is required for antibiotic production and for proper sporulation
J. Bacteriol.
190
4079-4083
2008
Streptomyces coelicolor
Xu, W.; Huang, J.; Cohen, S.N.
Autoregulation of AbsB (RNase III) expression in Streptomyces coelicolor by endoribonucleolytic cleavage of absB operon transcripts
J. Bacteriol.
190
5526-5530
2008
Streptomyces coelicolor (Q9ZBQ7)
Carzaniga, T.; Briani, F.; Zangrossi, S.; Merlino, G.; Marchi, P.; Deho, G.
Autogenous regulation of Escherichia coli polynucleotide phosphorylase expression revisited
J. Bacteriol.
191
1738-1748
2009
Bacteria
Meng, W.; Nicholson, R.H.; Nathania, L.; Pertzev, A.V.; Nicholson, A.W.
New approaches to understanding double-stranded RNA processing by ribonuclease III purification and assays of homodimeric and heterodimeric forms of RNase III from bacterial extremophiles and mesophiles
Methods Enzymol.
447
119-129
2008
Escherichia coli, Aquifex aeolicus (O67082), Aquifex aeolicus, Thermotoga maritima (Q9X0I6), Thermotoga maritima
Chevalier, C.; Huntzinger, E.; Fechter, P.; Boisset, S.; Vandenesch, F.; Romby, P.; Geissmann, T.
Staphylococcus aureus endoribonuclease III purification and properties
Methods Enzymol.
447
309-327
2008
Staphylococcus aureus
Gravenbeek, M.L.; Jones, G.H.
The endonuclease activity of RNase III is required for the regulation of antibiotic production by Streptomyces coelicolor
Microbiology
154
3547-3555
2008
Streptomyces coelicolor (Q9ZBQ7), Streptomyces coelicolor, Streptomyces coelicolor M145 (Q9ZBQ7)
Olmedo, G.; Guzman, P.
Mini-III, a fourth class of RNase III catalyses maturation of the Bacillus subtilis 23S ribosomal RNA
Mol. Microbiol.
68
1073-1076
2008
Bacillus subtilis
Redko, Y.; Bechhofer, D.H.; Condon, C.
Mini-III, an unusual member of the RNase III family of enzymes, catalyses 23S ribosomal RNA maturation in B. subtilis
Mol. Microbiol.
68
1096-1106
2008
Bacillus subtilis (O31418), Bacillus subtilis
Resch, A.; Afonyushkin, T.; Lombo, T.B.; McDowall, K.J.; Blaesi, U.; Kaberdin, V.R.
Translational activation by the noncoding RNA DsrA involves alternative RNase III processing in the rpoS 5-leader
RNA
14
454-459
2008
Escherichia coli
Xiao, J.; Feehery, C.E.; Tzertzinis, G.; Maina, C.V.
E. coli RNase III(E38A) generates discrete-sized products from long dsRNA
RNA
15
984-991
2009
Escherichia coli
Fang, P.; Wang, J.; Li, X.; Guo, M.; Xing, L.; Cao, X.; Zhu, Y.; Gao, Y.; Niu, L.; Teng, M.
Crystallization and preliminary X-ray analysis of Escherichia coli RNase G
Acta Crystallogr. Sect. F
65
586-588
2009
Escherichia coli K-12 (P0A9J0)
Jin, L.; Kryukov, K.; Suzuki, Y.; Imanishi, T.; Ikeo, K.; Gojobori, T.
The evolutionary study of small RNA-directed gene silencing pathways by investigating RNase III enzymes
Gene
435
1-8
2009
Caenorhabditis elegans, Cryptococcus neoformans, Dictyostelium discoideum, Drosophila melanogaster, Enterococcus faecalis, Homo sapiens
Dalzell, J.J.; Warnock, N.D.; Stevenson, M.A.; Mousley, A.; Fleming, C.C.; Maule, A.G.
Short interfering RNA-mediated knockdown of drosha and pasha in undifferentiated Meloidogyne incognita eggs leads to irregular growth and embryonic lethality
Int. J. Parasitol.
40
1303-1310
2010
Meloidogyne incognita
Georgi, S.A.; Reh, T.A.
Dicer is required for the transition from early to late progenitor state in the developing mouse retina
J. Neurosci.
30
4048-4061
2010
Mus musculus
Chen, T.S.; Lai, R.C.; Lee, M.M.; Choo, A.B.; Lee, C.N.; Lim, S.K.
Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs
Nucleic Acids Res.
38
215-224
2010
synthetic construct
Nathania, L.; Nicholson, A.W.
Thermotoga maritima ribonuclease III. Characterization of thermostable biochemical behavior and analysis of conserved base pairs that function as reactivity epitopes for the Thermotoga 23S rRNA precursor
Biochemistry
49
7164-7178
2010
Thermotoga maritima
Ando, Y.; Maida, Y.; Morinaga, A.; Burroughs, A.M.; Kimura, R.; Chiba, J.; Suzuki, H.; Masutomi, K.; Hayashizaki, Y.
Two-step cleavage of hairpin RNA with 5' overhangs by human DICER
BMC Mol. Biol.
12
6
2011
Homo sapiens (Q9UPY3), Homo sapiens
Kim, K.; Sim, S.H.; Jeon, C.O.; Lee, Y.; Lee, K.
Base substitutions at scissile bond sites are sufficient to alter RNA-binding and cleavage activity of RNase III
FEMS Microbiol. Lett.
315
30-37
2011
Escherichia coli
Opdyke, J.A.; Fozo, E.M.; Hemm, M.R.; Storz, G.
RNase III participates in GadY-dependent cleavage of the gadX-gadW mRNA
J. Mol. Biol.
406
29-43
2011
Escherichia coli
Hussain, M.; Abraham, A.M.; Asgari, S.
An Ascovirus-encoded RNase III autoregulates its expression and suppresses RNA interference-mediated gene silencing
J. Virol.
84
3624-3630
2010
Heliothis virescens ascovirus 3e
Cenik, E.S.; Fukunaga, R.; Lu, G.; Dutcher, R.; Wang, Y.; Tanaka Hall, T.M.; Zamore, P.D.
Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease
Mol. Cell
42
172-184
2011
Drosophila melanogaster
Deltcheva, E.; Chylinski, K.; Sharma, C.M.; Gonzales, K.; Chao, Y.; Pirzada, Z.A.; Eckert, M.R.; Vogel, J.; Charpentier, E.
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
Nature
471
602-607
2011
Streptococcus pyogenes, Streptococcus pyogenes SF370
Tang, X.; Zhang, Y.; Tucker, L.; Ramratnam, B.
Phosphorylation of the RNase III enzyme Drosha at serine 300 or serine 302 is required for its nuclear localization
Nucleic Acids Res.
38
6610-6619
2010
Drosophila melanogaster
Shi, Z.; Nicholson, R.H.; Jaggi, R.; Nicholson, A.W.
Characterization of Aquifex aeolicus ribonuclease III and the reactivity epitopes of its pre-ribosomal RNA substrates
Nucleic Acids Res.
39
2756-2768
2011
Aquifex aeolicus
Viegas, S.C.; Silva, I.J.; Saramago, M.; Domingues, S.; Arraiano, C.M.
Regulation of the small regulatory RNA MicA by ribonuclease III: a target-dependent pathway
Nucleic Acids Res.
39
2918-2930
2011
Salmonella enterica subsp. enterica serovar Typhimurium
Babiskin, A.H.; Smolke, C.D.
Engineering ligand-responsive RNA controllers in yeast through the assembly of RNase III tuning modules
Nucleic Acids Res.
39
5299-5311
2011
Saccharomyces cerevisiae
Liu, Y.; Dong, J.; Wu, N.; Gao, Y.; Zhang, X.; Mu, C.; Shao, N.; Fan, M.; Yang, G.
The production of extracellular proteins is regulated by ribonuclease III via two different pathways in Staphylococcus aureus
PLoS ONE
6
e20554
2011
Staphylococcus aureus, Staphylococcus aureus NCTC 8325
Madina, B.R.; Kuppan, G.; Vashisht, A.A.; Liang, Y.H.; Downey, K.M.; Wohlschlegel, J.A.; Ji, X.; Sze, S.H.; Sacchettini, J.C.; Read, L.K.; Cruz-Reyes, J.
Guide RNA biogenesis involves a novel RNase III family endoribonuclease in Trypanosoma brucei
RNA
17
1821-1830
2011
Trypanosoma brucei
Wang, Z.; Hartman, E.; Roy, K.; Chanfreau, G.; Feigon, J.
Structure of a yeast RNase III dsRBD complex with a noncanonical RNA substrate provides new insights into binding specificity of dsRBDs
Structure
19
999-1010
2011
Saccharomyces cerevisiae
Lee, J.H.; Gatewood, M.L.; Jones, G.H.
RNase III is required for actinomycin production in Streptomyces antibioticus
Appl. Environ. Microbiol.
79
6447-6451
2013
Streptomyces antibioticus (U3GP13), Streptomyces antibioticus IMRU 3720 (U3GP13)
Lien, P.C.; Kuo, P.H.; Chen, C.J.; Chang, H.H.; Fang, S.L.; Wu, W.S.; Lai, Y.K.; Pai, T.W.; Chang, M.D.
In silico prediction and in vitro characterization of multifunctional human RNase3
BioMed Res. Int.
2013
170398
2013
Homo sapiens
Lim, B.; Ahn, S.; Sim, M.; Lee, K.
RNase III controls mltD mRNA degradation in Escherichia coli
Curr. Microbiol.
68
518-523
2014
Escherichia coli, Escherichia coli HT115
Dewi, D.L.; Ishii, H.; Haraguchi, N.; Nishikawa, S.; Kano, Y.; Fukusumi, T.; Ozaki, M.; Saito, T.; Sakai, D.; Satoh, T.; Doki, Y.; Mori, M.
Dicer 1, ribonuclease type III modulates a reprogramming effect in colorectal cancer cells
Int. J. Mol. Med.
29
1060-1064
2012
Homo sapiens
Lim, B.; Sim, S.H.; Sim, M.; Kim, K.; Jeon, C.O.; Lee, Y.; Ha, N.C.; Lee, K.
RNase III controls the degradation of corA mRNA in Escherichia coli
J. Bacteriol.
194
2214-2220
2012
Escherichia coli, Escherichia coli MG1655
Weinheimer, I.; Boonrod, K.; Moser, M.; Wassenegger, M.; Krczal, G.; Butcher, S.J.; Valkonen, J.P.
Binding and processing of small dsRNA molecules by the class 1 RNase III protein encoded by sweet potato chlorotic stunt virus
J. Gen. Virol.
95
486-495
2014
sweet potato chlorotic stunt virus
Liang, Y.H.; Lavoie, M.; Comeau, M.A.; Abou Elela, S.; Ji, X.
Structure of a eukaryotic RNase III postcleavage complex reveals a double-ruler mechanism for substrate selection
Mol. Cell
54
431-444
2014
Saccharomyces cerevisiae (Q02555), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 (Q02555)
Johanson, T.M.; Lew, A.M.; Chong, M.M.
MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer
Open Biology
3
130144
2013
Arabidopsis thaliana, Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, Escherichia coli, Homo sapiens, Mus musculus
Lioliou, E.; Sharma, C.M.; Caldelari, I.; Helfer, A.C.; Fechter, P.; Vandenesch, F.; Vogel, J.; Romby, P.
Global regulatory functions of the Staphylococcus aureus endoribonuclease III in gene expression
PLoS Genet.
8
e1002782
2012
Staphylococcus aureus, Staphylococcus aureus RN6390
Durand, S.; Gilet, L.; Condon, C.
The essential function of B. subtilis RNase III is to silence foreign toxin genes
PLoS Genet.
8
e1003181
2012
Bacillus subtilis
Sim, M.; Lim, B.; Sim, S.H.; Kim, D.; Jung, E.; Lee, Y.; Lee, K.
Two tandem RNase III cleavage sites determine betT mRNA stability in response to osmotic stress in Escherichia coli
PLoS ONE
9
e100520
2014
Escherichia coli, Escherichia coli MG1655rnc
Kavalchuk, K.; Madhusudan, S.; Schnetz, K.
RNase III initiates rapid degradation of proU mRNA upon hypo-osmotic stress in Escherichia coli
RNA Biol.
9
98-109
2012
Escherichia coli
Malagon, F.
RNase III is required for localization to the nucleoid of the 5 pre-rRNA leader and for optimal induction of rRNA synthesis in E. coli
RNA
19
1200-1207
2013
Escherichia coli (B1XB41)
Nicholson, A.W.
Ribonuclease III mechanisms of double-stranded RNA cleavage
Wiley Interdiscip. Rev. RNA
5
31-48
2013
Saccharomyces cerevisiae, Escherichia coli, Homo sapiens, Schizosaccharomyces pombe, Giardia intestinalis (A8BQJ3), Aquifex aeolicus (O67082), Mycobacterium tuberculosis (P9WH03), Thermotoga maritima (Q9X0I6), Mycobacterium tuberculosis H37Rv (P9WH03)
Rath, E.C.; Pitman, S.; Cho, K.H.; Bai, Y.
Identification of streptococcal small RNAs that are putative targets of RNase III through bioinformatics analysis of RNA sequencing data
BMC Bioinformatics
18
540
2017
Streptococcus pyogenes, Streptococcus pyogenes serotype 14, Streptococcus pyogenes serotype 14 HSC5, Streptococcus pyogenes HSC5
Saramago, M.; Robledo, M.; Matos, R.; Jimenez-Zurdo, J.; Arraiano, C.
Sinorhizobium meliloti RNase III catalytic features and impact on symbiosis
Front. Genet.
9
350
2018
Sinorhizobium meliloti (Q92R47), Sinorhizobium meliloti
Setinova, D.; Smidova, K.; Pohl, P.; Music, I.; Bobek, J.
RNase III-binding-mRNAs revealed novel complementary transcripts in Streptomyces
Front. Microbiol.
8
2693
2017
Streptomyces coelicolor (Q9ZBQ7), Streptomyces coelicolor A3(2) (Q9ZBQ7), Streptomyces coelicolor ATCC BAA-471 (Q9ZBQ7), Streptomyces coelicolor M145 (Q9ZBQ7)
Wu, C.X.; Xu, X.J.; Zheng, K.; Liu, F.; Yang, X.D.; Chen, C.F.; Chen, H.C.; Liu, Z.F.
Characterization of ribonuclease III from Brucella
Gene
579
183-192
2016
Brucella melitensis, Brucella melitensis 027
Carzaniga, T.; Deho, G.; Briani, F.
RNase III-independent autogenous regulation of Escherichia coli polynucleotide phosphorylase via translational repression
J. Bacteriol.
197
1931-1938
2015
Escherichia coli (P0A7Y0)
Anacker, M.L.; Drecktrah, D.; LeCoultre, R.D.; Lybecker, M.; Samuels, D.S.
RNase III processing of rRNA in the Lyme disease spirochete Borrelia burgdorferi
J. Bacteriol.
200
e00035-18
2018
Borreliella burgdorferi (O51648), Borreliella burgdorferi
Yang, L.; Wang, Y.L.; Dai, J.C.; Liu, M.; Li, X.; Tang, H.
Biochemical properties of Bacillus Calmette Guerin ribonuclease III
J. Basic Microbiol.
56
392-404
2016
Mycobacterium tuberculosis variant bovis (A0A0H3M8A2), Mycobacterium tuberculosis variant bovis Pasteur 1173P2 (A0A0H3M8A2)
Lim, B.; Sim, M.; Lee, H.; Hyun, S.; Lee, Y.; Hahn, Y.; Shin, E.; Lee, K.
Regulation of Escherichia coli RNase III activity
J. Microbiol.
53
487-494
2015
Aquifex aeolicus (O67082), Escherichia coli (P0A7Y0), Escherichia coli
Gordon, G.; Cameron, J.; Pfleger, B.
RNA sequencing identifies new RNase III cleavage sites in Escherichia coli and reveals increased regulation of mRNA
mBio
8
e00128-17
2017
Escherichia coli (P0A7Y0), Escherichia coli MG1693 (P0A7Y0)
Maeda, T.; Tanaka, Y.; Takemoto, N.; Hamamoto, N.; Inui, M.
RNase III mediated cleavage of the coding region of mraZ mRNA is required for efficient cell division in Corynebacterium glutamicum
Mol. Microbiol.
99
1149-1166
2016
Corynebacterium glutamicum (A4QFE0), Corynebacterium glutamicum
Carnes, J.; McDermott, S.; Stuart, K.
RNase III domain of KREPB9 and KREPB10 association with editosomes in Trypanosoma brucei
mSphere
3
e00585-17
2018
Trypanosoma brucei (Q38F97), Trypanosoma brucei (Q57X12), Trypanosoma brucei 927/4 GUTat10.1 (Q38F97), Trypanosoma brucei 927/4 GUTat10.1 (Q57X12)
Comeau, M.A.; Lafontaine, D.A.; Abou Elela, S.
The catalytic efficiency of yeast ribonuclease III depends on substrate specific product release rate
Nucleic Acids Res.
44
7911-7921
2016
Saccharomyces cerevisiae (C7GRB2), Saccharomyces cerevisiae, Saccharomyces cerevisiae JAY291 (C7GRB2)
Le Rhun, A.; Lecrivain, A.L.; Reimegard, J.; Proux-Wera, E.; Broglia, L.; Della Beffa, C.; Charpentier, E.
Identification of endoribonuclease specific cleavage positions reveals novel targets of RNase III in Streptococcus pyogenes
Nucleic Acids Res.
45
2329-2340
2017
Streptococcus pyogenes serotype M1 (P66670), Streptococcus pyogenes serotype M1 SF370 (M1GAS) (P66670)
Altuvia, Y.; Bar, A.; Reiss, N.; Karavani, E.; Argaman, L.; Margalit, H.
In vivo cleavage rules and target repertoire of RNase III in Escherichia coli
Nucleic Acids Res.
46
10380-10394
2018
Escherichia coli (P0A7Y0), Escherichia coli MG1655 (P0A7Y0)
Xu, W.; Liu, Y.; Liu, Y.; Liu, L.; Zhan, Y.; Zhuang, C.; Lin, J.; Chen, M.; Li, J.; Cai, Z.; Huang, W.; Zhang, Y.
Artificial small RNA for sequence specific cleavage of target RNA through RNase III endonuclease Dicer
Oncotarget
7
54549-54554
2016
Homo sapiens (Q9UPY3)
Hotto, A.M.; Castandet, B.; Gilet, L.; Higdon, A.; Condon, C.; Stern, D.B.
Arabidopsis chloroplast mini-ribonuclease III participates in rRNA maturation and intron recycling
Plant Cell
27
724-740
2015
Arabidopsis thaliana (Q6NQK8), Arabidopsis thaliana (Q94F12), Arabidopsis thaliana
Paudyal, S.; Alfonso-Prieto, M.; Carnevale, V.; Redhu, S.; Klein, M.; Nicholson, A.
Combined computational and experimental analysis of a complex of ribonuclease III and the regulatory macrodomain protein, YmdB
Proteins
83
459-472
2015
Escherichia coli (P0A7Y0), Escherichia coli
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