Reference on EC 3.1.26.13 - retroviral ribonuclease H
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Focher, F.; Maga, G.; Bendiscioli, A.; Capobianco, M.; Colonna, F.; Garbesi, A.; Spadari, S.
Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5'-triphosphate as substrate
Nucleic Acids Res.
23
2840-2847
1995
Escherichia coli, Homo sapiens, Human alphaherpesvirus 1, Human immunodeficiency virus 1, Human Immunodeficiency Virus
Roth, M.J.; Tanese, N.; Goff, S.P.
Purification and characterization of murine retroviral reverse transcriptase expressed in Escherichia coli
J. Biol. Chem.
260
9326-9335
1985
Moloney murine leukemia virus
Rausch, J.W.; Lener, D.; Miller, J.T.; Julias, J.G.; Hughes, S.H.; Le Grice, S.F.J.
Altering the RNase H primer grip of human immunodeficiency virus reverse transcriptase modifies cleavage specificity
Biochemistry
41
4856-4865
2002
BRENDA: Human immunodeficiency virus 1
Textmining: Human Immunodeficiency Virus
Guaitiao, J.P.; Zuniga, R.A.; Roth, M.J.; Leon, O.
Lysine directed cross-linking of viral DNA-RNA:DNA hybrid substrate to the isolated RNase H domain of HIV-1 reverse transcriptase
Biochemistry
43
1302-1308
2004
Human immunodeficiency virus 1
Lener, D.; Budihas, S.R.; Le Grice, S.F.J.
Mutating conserved residues in the ribonuclease H domain of Ty3 reverse transcriptase affects specialized cleavage events
J. Biol. Chem.
277
26486-26495
2002
Saccharomyces cerevisiae
Sevilya, Z.; Loya, S.; Hughes, S.H.; Hizi, A.
The ribonuclease H activity of the reverse transcriptases of human immunodeficiency viruses type 1 and type 2 is affected by the thumb subdomain of the small protein subunits
J. Mol. Biol.
311
957-971
2001
Human immunodeficiency virus 1, Human immunodeficiency virus 2, Human immunodeficiency virus 2 D-194, Human immunodeficiency virus 2 ROD
Sevilya, Z.; Loya, S.; Duvshani, A.; Adir, N.; Hizi, A.
Mutagenesis of cysteine 280 of the reverse transcriptase of human immunodeficiency virus type-1: The effects on the ribonuclease H activity
J. Mol. Biol.
327
19-30
2003
Human immunodeficiency virus 1
Hildmann, C.; Ninkovic, M.; Dietrich, R.; Wegener, D.; Riester, D.; Zimmermann, T.; Birch, O.M.; Bernegger, C.; Loidl, P.; Schwienhorst, A.
A new amidohydrolase from Bordetella or Alcaligenes strain FB188 with similarities to histone deacetylases
J. Bacteriol.
186
2328-2339
2004
Human Immunodeficiency Virus
Deval, J.; Navarro, J.M.; Selmi, B.; Courcambeck, J.; Boretto, J.; Halfon, P.; Garrido-Urbani, S.; Sire, J.; Canard, B.
A loss of viral replicative capacity correlates with altered DNA polymerization kinetics by the human immunodeficiency virus reverse transcriptase bearing the K65R and L74V dideoxynucleoside resistance substitutions
J. Biol. Chem.
279
25489-25496
2004
Human Immunodeficiency Virus
Schultz, S.J.; Zhang, M.; Champoux, J.J.
Sequence, distance, and accessibility are determinants of 5'-end-directed cleavages by retroviral RNases H
J. Biol. Chem.
281
1943-1955
2006
Human immunodeficiency virus 1, Moloney murine leukemia virus
Schultz, S.J.; Zhang, M.; Champoux, J.J.
Recognition of internal cleavage sites by retroviral RNases H
J. Mol. Biol.
344
635-652
2004
Human immunodeficiency virus 1, Moloney murine leukemia virus
Budihas, S.R.; Gorshkova, I.; Gaidamakov, S.; Wamiru, A.; Bona, M.K.; Parniak, M.A.; Crouch, R.J.; McMahon, J.B.; Beutler, J.A.; Le Grice, S.F.J.
Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones
Nucleic Acids Res.
33
1249-1256
2005
Human immunodeficiency virus 1, Escherichia coli, Homo sapiens
Purohit, V.; Roques, B.P.; Kim, B.; Bambara, R.A.
Mechanisms that prevent template inactivation by HIV-1 reverse transcriptase RNase H cleavages
J. Biol. Chem.
282
12598-12609
2007
Human immunodeficiency virus 1
Brehm, J.H.; Mellors, J.W.; Sluis-Cremer, N.
Mechanism by which a glutamine to leucine substitution at residue 509 in the ribonuclease H domain of HIV-1 reverse transcriptase confers zidovudine resistance
Biochemistry
47
14020-14027
2008
Human immunodeficiency virus 1
Roquebert, B.; Marcelin, A.G.
The involvement of HIV-1 RNAse H in resistance to nucleoside analogues
J. Antimicrob. Chemother.
61
973-975
2008
Human immunodeficiency virus 1
Fuji, H.; Urano, E.; Futahashi, Y.; Hamatake, M.; Tatsumi, J.; Hoshino, T.; Morikawa, Y.; Yamamoto, N.; Komano, J.
Derivatives of 5-nitrofuran-2-carboxylic acid carbamoyl methyl ester inhibit RNase H activity associated with HIV-1 reverse transcriptase
J. Med. Chem.
52
1380-1387
2009
Human immunodeficiency virus 1, Moloney murine leukemia virus
Bokesch, H.R.; Wamiru, A.; Le Grice, S.F.; Beutler, J.A.; McKee, T.C.; McMahon, J.B.
HIV-1 ribonuclease H inhibitory phenolic glycosides from Eugenia hyemalis
J. Nat. Prod.
71
1634-1636
2008
Human immunodeficiency virus 1
Yu, F.; Liu, X.; Zhan, P.; De Clercq, E.
Recent advances in the research of HIV-1 RNase H inhibitors
Mini Rev. Med. Chem.
8
1243-1251
2008
Human immunodeficiency virus 1
Waters, J.; ONeal, W.; White, K.; Wakeford, C.; Lansdon, E.; Harris, J.; Svarovskaia, E.; Miller, M.; Borroto-Esoda, K.
Mutations in the thumb-connection and RNase H domain of HIV type-1 reverse transcriptase of antiretroviral treatment-experienced patients
Antivir. Ther. (Lond. )
14
231-239
2009
Human immunodeficiency virus 1
Allen, S.; Krawczyk, S.; McGee, L.; Bischofberger, N.; Mulato, A.; Cherrington, J.
Inhibition of HIV-1 RNase H activity by nucleotide dimers and monomers
Antiviral Chem. Chemother.
7
37-45
1996
Human immunodeficiency virus 1, Moloney murine leukemia virus
-
Mizrahi, V.
Analysis of the ribonuclease H activity of HIV-1 reverse transcriptase using RNA-DNA hybrid substrates derived from the gag region of HIV-1
Biochemistry
28
9088-9094
1989
Human immunodeficiency virus 1
Furfine, E.S.; Reardon, J.E.
Human immunodeficiency virus reverse transcriptase ribonuclease H: specificity of tRNA(Lys3)-primer excision
Biochemistry
30
7041-7046
1991
Avian myeloblastosis virus, Human Immunodeficiency Virus, Moloney murine leukemia virus
Peliska, J.A.; Balasubramanian, S.; Giedroc, D.P.; Benkovic, S.J.
Recombinant HIV-1 nucleocapsid protein accelerates HIV-1 reverse transcriptase catalyzed DNA strand transfer reactions and modulates RNase H activity
Biochemistry
33
13817-13823
1994
Human immunodeficiency virus 1
Cirino, N.M.; Cameron, C.E.; Smith, J.S.; Rausch, J.W.; Roth, M.J.; Benkovic, S.J.; Le Grice, S.F.
Divalent cation modulation of the ribonuclease functions of human immunodeficiency virus reverse transcriptase
Biochemistry
34
9936-9943
1995
Human Immunodeficiency Virus
Ghosh, M.; Williams, J.; Powell, M.D.; Levin, J.G.; Le Grice, S.F.
Mutating a conserved motif of the HIV-1 reverse transcriptase palm subdomain alters primer utilization
Biochemistry
36
5758-5768
1997
Human immunodeficiency virus 1
Gabbara, S.; Davis, W.R.; Hupe, L.; Hupe, D.; Peliska, J.A.
Inhibitors of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase
Biochemistry
38
13070-13076
1999
Human immunodeficiency virus 1
Davis, W.R.; Tomsho, J.; Nikam, S.; Cook, E.M.; Somand, D.; Peliska, J.A.
Inhibition of HIV-1 reverse transcriptase-catalyzed DNA strand transfer reactions by 4-chlorophenylhydrazone of mesoxalic acid
Biochemistry
39
14279-14291
2000
Human immunodeficiency virus 1
Starnes, M.; Cheng, Y.
Human immunodeficiency virus reverse transcriptase-associated RNase H activity
J. Biol. Chem.
264
7073-7077
1989
BRENDA: Human Immunodeficiency Virus
Textmining: Human immunodeficiency virus 1
Cirino, N.M.; Kalayjian, R.C.; Jentoft, J.E.; Le Grice, S.F.
Fluorimetric analysis of recombinant p15 HIV-1 ribonuclease H
J. Biol. Chem.
268
14743-14749
1993
Human immunodeficiency virus 1
Volkmann, S.; Wohrl, B.; Tisdale, M.; Moelling, K.
Enzymatic analysis of two HIV-1 reverse transcriptase mutants with mutations in carboxyl-terminal amino acid residues conserved among retroviral ribonucleases H
J. Biol. Chem.
268
2674-2683
1993
Human immunodeficiency virus 1
Ghosh, M.; Howard, K.J.; Cameron, C.E.; Benkovic, S.J.; Hughes, S.H.; Le Grice, S.F.
Truncating alpha-helix E of p66 human immunodeficiency virus reverse transcriptase modulates RNase H function and impairs DNA strand transfer
J. Biol. Chem.
270
7068-7076
1995
BRENDA: Human immunodeficiency virus 1
Textmining: Human Immunodeficiency Virus
Rausch, J.W.; Le Grice, S.F.J.
Substituting a conserved residue of ribonuclease H domain alters substrate hydrolysis by retroviral reverse transcriptase
J. Biol. Chem.
272
8602-8610
1997
BRENDA: Human Immunodeficiency Virus
Textmining: Homo sapiens, Equus caballus, Viruses
Misra, H.; Pandey, P.; Pandey, V.
An enzymatically active chimeric HIV-1 reverse transcriptase (RT) with the RNase-H domain of murine leukemia virus RT exists as a monomer
J. Biol. Chem.
273
9785-9789
1998
murine leukemia virus
Schultz, S.J.; Zhang, M.; Kelleher, C.D.; Champoux, J.J.
Analysis of plus-strand primer selection, removal, and reutilization by retroviral reverse transcriptases
J. Biol. Chem.
275
32299-32309
2000
Moloney murine leukemia virus
Gao, H.; Sarafianos, S.; Arnold, E.; Hughes, S.
Similarities and differences in the RNase H activities of human immunodeficiency virus type 1 reverse transcriptase and Moloney murine leukemia virus reverse transcriptase
J. Mol. Biol.
294
1097-1113
1999
Human immunodeficiency virus 1, Moloney murine leukemia virus
Moelling, K.; Schulze, T.; Diringer, H.
Inhibition of human immunodeficiency virus type 1 RNase H by sulfated polyanions
J. Virol.
63
5489-5491
1989
Human immunodeficiency virus 1
Fu, T.; Taylor, J.
When retroviral reverse transcriptases reach the end of their RNA templates
J. Virol.
66
4271-4278
1992
Human immunodeficiency virus 1
Brincat, J.L.; Pfeiffer, J.K.; Telesnitsky, A.
RNase H activity is required for high-frequency repeat deletion during Moloney murine leukemia virus replication
J. Virol.
76
88-95
2002
Moloney murine leukemia virus
Nikolenko, G.; Palmer, S.; Maldarelli, F.; Mellors, J.; Coffin, J.; Pathak, V.
Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: Balance between RNase H activity and nucleotide excision
Proc. Natl. Acad. Sci. USA
102
2093-2098
2005
Human immunodeficiency virus 1
Julias, J.; McWilliams, M.; Sarafianos, S.; Arnold, E.; Hughes, S.
Mutations in the RNase H domain of HIV-1 reverse transcriptase affect the initiation of DNA synthesis and the specificity of RNase H cleavage in vivo
Proc. Natl. Acad. Sci. USA
99
9515-9520
2002
Human immunodeficiency virus 1
Goedken, E.R.; Marqusee, S.
Metal binding and activation of the ribonuclease H domain from Moloney murine leukemia virus
Protein Eng.
12
975-980
1999
Moloney murine leukemia virus
Kern, G.; Handel, T.; Marqusee, S.
Characterization of a folding intermediate from HIV-1 ribonuclease H
Protein Sci.
7
2164-2174
1998
Human immunodeficiency virus 1
Temiz, N.; Bahar, I.
Inhibitor binding alters the directions of domain motions in HIV-1 reverse transcriptase
Proteins Struct. Funct. Genet.
49
61-70
2002
Human immunodeficiency virus 1
Davies II, J.; Hostomska, Z.; Hostomsky, Z.; Jordan, S.; Matthews, D.
Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase
Science
252
88-95
1991
Human immunodeficiency virus 1
Jones, F.D.; Hughes, S.H.
In vitro analysis of the effects of mutations in the G-tract of the human immunodeficiency virus type 1 polypurine tract on RNase H cleavage specificity
Virology
360
341-349
2007
Human immunodeficiency virus 1
Hachiya, A.; Shimane, K.; Sarafianos, S.G.; Kodama, E.N.; Sakagami, Y.; Negishi, F.; Koizumi, H.; Gatanaga, H.; Matsuoka, M.; Takiguchi, M.; Oka, S.
Clinical relevance of substitutions in the connection subdomain and RNase H domain of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naive patients
Antiviral Res.
82
115-121
2009
Human immunodeficiency virus 1 (P03366)
Seckler, J.; Howard, K.; Barkley, M.; Wintrode, P.
Solution structural dynamics of HIV-1 reverse transcriptase heterodimer
Biochemistry
48
7646-7655
2009
Human immunodeficiency virus 1 (P03366)
Di Grandi, M.; Olson, M.; Prashad, A.S.; Bebernitz, G.; Luckay, A.; Mullen, S.; Hu, Y.; Krishnamurthy, G.; Pitts, K.; OConnell, J.
Small molecule inhibitors of HIV RT Ribonuclease H
Bioorg. Med. Chem. Lett.
20
398-402
2010
Human immunodeficiency virus 1
Mizuno, M.; Yasukawa, K.; Inouye, K.
Insight into the mechanism of the stabilization of Moloney murine leukaemia virus reverse transcriptase by eliminating RNase H activity
Biosci. Biotechnol. Biochem.
74
440-442
2010
Moloney murine leukemia virus
Kharlamova, T.
Synthesis of phenacyl derivatives of frangula-emodin and their HIV-1 RNase H activity
Chem. Nat. Compd.
45
500-502
2009
Human immunodeficiency virus 1
-
Kirschberg, T.A.; Balakrishnan, M.; Squires, N.H.; Barnes, T.; Brendza, K.M.; Chen, X.; Eisenberg, E.J.; Jin, W.; Kutty, N.; Leavitt, S.; Liclican, A.; Liu, Q.; Liu, X.; Mak, J.; Perry, J.K.; Wang, M.; Watkins, W.J.; Lansdon, E.B.
RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information
J. Med. Chem.
52
5781-5784
2009
Human immunodeficiency virus 1
Esposito, F.; Fanti, V.; Marzeddu, R.; Randaccio, P.; Tramontano, E.; Zinzula, L.
Validation of a computed radiography device to monitor the HIV-1 RNase H activity
Nucl. Instrum. Meth. Phys. Res. A
607
226-228
2009
Human immunodeficiency virus 1
-
Wahba, A.S.; Esmaeili, A.; Damha, M.J.; Hudson, R.H.
A single-label phenylpyrrolocytidine provides a molecular beacon-like response reporting HIV-1 RT RNase H activity
Nucleic Acids Res.
38
1048-1056
2010
Human immunodeficiency virus 1
Himmel, D.M.; Maegley, K.A.; Pauly, T.A.; Bauman, J.D.; Das, K.; Dharia, C.; Clark, A.D.; Ryan, K.; Hickey, M.J.; Love, R.A.; Hughes, S.H.; Bergqvist, S.; Arnold, E.
Structure of HIV-1 reverse transcriptase with the inhibitor beta-thujaplicinol bound at the RNase H active site
Structure
17
1625-1635
2009
Human immunodeficiency virus 1 (P03366)
Talele, T.; Upadhyay, A.; Pandey, V.
Influence of the RNase H domain of retroviral reverse transcriptases on the metal specificity and substrate selection of their polymerase domains
Virol. J.
6
159-170
2009
Human immunodeficiency virus 1, Moloney murine leukemia virus
Xu, H.; Quan, Y.; Schader, S.; Oliveira, M.; Bar-Magen, T.; Wainberg, M.
The M230L nonnucleoside reverse transcriptase inhibitor resistance mutation in HIV-1 reverse transcriptase impairs enzymatic function and viral replicative capacity
Antimicrob. Agents Chemother.
54
2401-2408
2010
Human immunodeficiency virus 1, Human immunodeficiency virus 1 HXB2
Farias, R.V.; Vargas, D.A.; Castillo, A.E.; Valenzuela, B.; Cote, M.L.; Roth, M.J.; Leon, O.
Expression of an Mg2+-dependent HIV-1 RNase H construct for drug screening
Antimicrob. Agents Chemother.
55
4735-4741
2011
Human immunodeficiency virus 1
Yanagita, H.; Urano, E.; Matsumoto, K.; Ichikawa, R.; Takaesu, Y.; Ogata, M.; Murakami, T.; Wu, H.; Chiba, J.; Komano, J.; Hoshino, T.
Structural and biochemical study on the inhibitory activity of derivatives of 5-nitro-furan-2-carboxylic acid for RNase H function of HIV-1 reverse transcriptase
Bioorg. Med. Chem.
19
816-825
2011
Human immunodeficiency virus 1
Kumar, A.
Binding of dumbbell oligonucleotides to MoMuLV reverse transcriptase: inhibitory properties of RNase H activity
E-J. Chem.
7
701-708
2010
Moloney murine leukemia virus
-
Billamboz, M.; Bailly, F.; Lion, C.; Calmels, C.; Andreola, M.L.; Witvrouw, M.; Christ, F.; Debyser, Z.; De Luca, L.; Chimirri, A.; Cotelle, P.
2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4
Eur. J. Med. Chem.
46
535-546
2011
BRENDA: Human Immunodeficiency Virus
Textmining: Human immunodeficiency virus 1
Esposito, F.; Kharlamova, T.; Distinto, S.; Zinzula, L.; Cheng, Y.C.; Dutschman, G.; Floris, G.; Markt, P.; Corona, A.; Tramontano, E.
Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases
FEBS J.
278
1444-1457
2011
Human immunodeficiency virus 1
Biondi, M.J.; Beilhartz, G.L.; McCormick, S.; Goette, M.
N348I in HIV-1 reverse transcriptase can counteract the nevirapine-mediated bias toward RNase H cleavage during plus-strand initiation
J. Biol. Chem.
285
26966-26975
2010
Human immunodeficiency virus 1, Human immunodeficiency virus 1 HXB-2
Billamboz, M.; Bailly, F.; Lion, C.; Touati, N.; Vezin, H.; Calmels, C.; Andreola, M.; Christ, F.; Debyser, Z.; Cotelle, P.
Magnesium chelating 2-hydroxyisoquinoline-1,3(2H, 4H)-diones, as inhibitors of HIV-1 integrase and/or the HIV-1 reverse transcriptase ribonuclease H domain: Discovery of a novel selective inhibitor of the ribonuclease H function
J. Med. Chem.
54
1812-1824
2011
BRENDA: Moloney murine leukemia virus
Textmining: Human immunodeficiency virus 1
Chung, S.; Himmel, D.; Jiang, J.; Wojtak, K.; Bauman, J.; Rausch, J.; Wilson, J.; Beutler, J.; Thomas, C.; Arnold, E.; Le Grice, S.
Synthesis, activity, and structural analysis of novel alpha-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H
J. Med. Chem.
54
4462-4473
2011
BRENDA: Human immunodeficiency virus 1
Textmining: Human Immunodeficiency Virus
Su, H.P.; Yan, Y.; Prasad, G.S.; Smith, R.F.; Daniels, C.L.; Abeywickrema, P.D.; Reid, J.C.; Loughran, H.M.; Kornienko, M.; Sharma, S.; Grobler, J.A.; Xu, B.; Sardana, V.; Allison, T.J.; Williams, P.D.; Darke, P.L.; Hazuda, D.J.; Munshi, S.
Structural basis for the inhibition of RNase H activity of HIV-1 reverse transcriptase by RNase H active site-directed inhibitors
J. Virol.
84
7625-7633
2010
Human immunodeficiency virus 1 (P0C6F2), Human immunodeficiency virus 1 HXB2 (P0C6F2)
Wang, J.; Bambara, R.A.; Demeter, L.M.; Dykes, C.
Reduced fitness in cell culture of HIV-1 with nonnucleoside reverse transcriptase inhibitor-resistant mutations correlates with relative levels of reverse transcriptase content and RNase H activity in virions
J. Virol.
84
9377-9389
2010
Human immunodeficiency virus 1
Radzvilavicius, T.; Lagunavicius, A.
Selective inactivation of M-MuLV RT RNase H activity by site-directed PEGylation: an improved ability to synthesize long cDNA molecules
New Biotechnol.
29
285-292
2012
Moloney murine leukemia virus
Lu, M.; Ngo, W.; Mei, Y.; Munshi, V.; Burlein, C.; Loughran, M.; Williams, P.; Hazuda, D.; Miller, M.; Grobler, J.; Diamond, T.; Lai, M.
Purification of untagged HIV-1 reverse transcriptase by affinity chromatography
Protein Expr. Purif.
71
231-239
2010
Human immunodeficiency virus 1
Delviks-Frankenberry, K.A.; Nikolenko, G.N.; Pathak, V.K.
The connection between HIV drug resistance and RNase H
Viruses
2
1476-1503
2010
Human immunodeficiency virus 1, Human immunodeficiency virus 1 HXB2
Singh, K.; Marchand, B.; Kirby, K.; Michailidis, E.; Sarafianos, S.
Structural aspects of drug resistance and inhibition of HIV-1 reverse transcriptase
Viruses
2
606-638
2010
Human immunodeficiency virus 1
Beilhartz, G.; Goette, M.
HIV-1 ribonuclease H: structure, catalytic mechanism and inhibitors
Viruses
2
900-926
2010
Human immunodeficiency virus 1, Human immunodeficiency virus 2
Sarafianos, S.G.; Das, K.; Tantillo, C.; Clark, A.D., Jr.; Ding, J.; Whitcomb, J.M.; Boyer, P.L.; Hughes, S.H.; Arnold, E.
Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA
EMBO J.
20
1449-1461
2001
Human immunodeficiency virus 1 (P03366)
Li, M.; Shandilya, S.M.; Carpenter, M.A.; Rathore, A.; Brown, W.L.; Perkins, A.L.; Harki, D.A.; Solberg, J.; Hook, D.J.; Pandey, K.K.; Parniak, M.A.; Johnson, J.R.; Krogan, N.J.; Somasundaran, M.; Ali, A.; Schiffer, C.A.; Harris, R.S.
First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G
ACS Chem. Biol.
7
506-517
2012
Escherichia coli, Human immunodeficiency virus 1
You, D.J.; Chon, H.; Koga, Y.; Takano, K.; Kanaya, S.
Crystal structure of type 1 ribonuclease H from hyperthermophilic archaeon Sulfolobus tokodaii: role of arginine 118 and C-terminal anchoring
Biochemistry
46
11494-11503
2007
Escherichia coli, Human immunodeficiency virus 1, Alkalihalobacillus halodurans
Broecker, F.; Andrae, K.; Moelling, K.
Premature activation of the HIV RNase H drives the virus into suicide: a novel microbicide?
AIDS Res. Hum. Retroviruses
28
1397-1403
2012
Human Immunodeficiency Virus
Corona, A.; Di Leva, F.S.; Thierry, S.; Pescatori, L.; Cuzzucoli Crucitti, G.; Subra, F.; Delelis, O.; Esposito, F.; Rigogliuso, G.; Costi, R.; Cosconati, S.; Novellino, E.; Di Santo, R.; Tramontano, E.
Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by diketo acid derivatives
Antimicrob. Agents Chemother.
58
6101-6110
2014
Human immunodeficiency virus 1
Muchiri, J.M.; Li, D.; Dykes, C.; Bambara, R.A.
Efavirenz stimulates HIV-1 reverse transcriptase RNase H activity by a mechanism involving increased substrate binding and secondary cleavage activity
Biochemistry
52
4981-4990
2013
Human immunodeficiency virus 1
Ilina, T.; Labarge, K.; Sarafianos, S.G.; Ishima, R.; Parniak, M.A.
Inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H activity
Biology
1
521-541
2012
Human immunodeficiency virus 1
Velthuisen, E.J.; Johns, B.A.; Gerondelis, P.; Chen, Y.; Li, M.; Mou, K.; Zhang, W.; Seal, J.W.; Hightower, K.E.; Miranda, S.R.; Brown, K.; Leesnitzer, L.
Pyridopyrimidinone inhibitors of HIV-1 RNase H
Eur. J. Med. Chem.
83
609-616
2014
Human immunodeficiency virus 1
Corona, A.; Masaoka, T.; Tocco, G.; Tramontano, E.; Le Grice, S.F.
Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase
Future Med. Chem.
5
2127-2139
2013
Human immunodeficiency virus 1
Beilhartz, G.L.; Ngure, M.; Johns, B.A.; DeAnda, F.; Gerondelis, P.; Goette, M.
Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation
J. Biol. Chem.
289
16270-16277
2014
Human immunodeficiency virus 1
Costi, R.; Metifiot, M.; Chung, S.; Cuzzucoli Crucitti, G.; Maddali, K.; Pescatori, L.; Messore, A.; Madia, V.N.; Pupo, G.; Scipione, L.; Tortorella, S.; Di Leva, F.S.; Cosconati, S.; Marinelli, L.; Novellino, E.; Le Grice, S.F.; Corona, A.; Pommier, Y.; Marchand, C.; Di Santo, R.
Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase
J. Med. Chem.
57
3223-3234
2014
Human immunodeficiency virus 1
Himmel, D.M.; Myshakina, N.S.; Ilina, T.; Van Ry, A.; Ho, W.C.; Parniak, M.A.; Arnold, E.
Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNase H domain of HIV-1 reverse transcriptase and structure-activity analysis of inhibitor analogs
J. Mol. Biol.
426
2617-2631
2014
Human immunodeficiency virus 1
Zheng, X.; Mueller, G.A.; DeRose, E.F.; London, R.E.
Metal and ligand binding to the HIV-RNase H active site are remotely monitored by Ile556
Nucleic Acids Res.
40
10543-10553
2012
Human immunodeficiency virus 1
Alvarez, M.; Barrioluengo, V.; Afonso-Lehmann, R.N.; Menendez-Arias, L.
Altered error specificity of RNase H-deficient HIV-1 reverse transcriptases during DNA-dependent DNA synthesis
Nucleic Acids Res.
41
4601-4612
2013
Human immunodeficiency virus 1
Zheng, X.; Pedersen, L.C.; Gabel, S.A.; Mueller, G.A.; Cuneo, M.J.; DeRose, E.F.; Krahn, J.M.; London, R.E.
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Human immunodeficiency virus 1
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Human immunodeficiency virus 1
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Human immunodeficiency virus 1
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A homogeneous, solid-phase assay for hepatitis C virus RNA-dependent RNA polymerase.
Anal Biochem
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Hepacivirus C, Human Immunodeficiency Virus
Kati, WM; Johnson, KA; Jerva, LF; Anderson, KS
Mechanism and fidelity of HIV reverse transcriptase.
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Human Immunodeficiency Virus
Fischer, M; Lifshitz, R; Katz, T; Liefer, I; Ben-Artzi, H; Gorecki, M; Panet, A; Zeelon, E
Comparative analysis of native and cysteine-deficient HIV-1 reverse transcriptase.
Protein Expr Purif
3
301-7
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Escherichia coli, Human Immunodeficiency Virus
Beard, WA; Wilson, SH
Site-directed mutagenesis of HIV reverse transcriptase to probe enzyme processivity and drug binding.
Curr Opin Biotechnol
5
414-21
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Human Immunodeficiency Virus
Bebenek, K; Abbotts, J; Wilson, SH; Kunkel, TA
Error-prone polymerization by HIV-1 reverse transcriptase. Contribution of template-primer misalignment, miscoding, and termination probability to mutational hot spots.
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Human Immunodeficiency Virus
Fuentes, GM; Rodríguez-Rodríguez, L; Palaniappan, C; Fay, PJ; Bambara, RA
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Human immunodeficiency virus 1, Human Immunodeficiency Virus
Ghosh, M; Jacques, PS; Rodgers, DW; Ottman, M; Darlix, JL; Le Grice, SF
Alterations to the primer grip of p66 HIV-1 reverse transcriptase and their consequences for template-primer utilization.
Biochemistry
35
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1996
Human Immunodeficiency Virus
El Dirani-Diab, R; Sarih-Cottin, L; Delord, B; Dumon, B; Moreau, S; Toulme, JJ; Fleury, H; Litvak, S
Phosphorothioate oligonucleotides derived from human immunodeficiency virus type 1 (HIV-1) primer tRNALys3 are strong inhibitors of HIV-1 reverse transcriptase and arrest viral replication in infected cells.
Antimicrob Agents Chemother
41
2141-8
1997
Human immunodeficiency virus 1
Hayakawa, N; Nozawa, K; Ogawa, A; Kato, N; Yoshida, K; Akamatsu, K; Tsuchiya, M; Nagasaka, A; Yoshida, S
Isothiazolone derivatives selectively inhibit telomerase from human and rat cancer cells in vitro.
Biochemistry
38
11501-7
1999
Human Immunodeficiency Virus
Wisniewski, M; Palaniappan, C; Fu, Z; Le Grice, SF; Fay, P; Bambara, RA
Mutations in the primer grip region of HIV reverse transcriptase can increase replication fidelity.
J Biol Chem
274
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1999
Human Immunodeficiency Virus
Morris, MC; Berducou, C; Mery, J; Heitz, F; Divita, G
The thumb domain of the P51-subunit is essential for activation of HIV reverse transcriptase.
Biochemistry
38
15097-103
1999
Human Immunodeficiency Virus
Karim, AS; Weltman, JK
Transcription of 2'-deoxy-2'-fluoro-modified and phosphorothioate-modified RNA templates by HIV-1 reverse transcriptase.
Anticancer Res
19
5419-21
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Human Immunodeficiency Virus
Figlerowicz, M; Bibiłło, A
RNA motifs mediating in vivo site-specific nonhomologous recombination in (+) RNA virus enforce in vitro nonhomologous crossovers with HIV-1 reverse transcriptase.
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6
339-51
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Human Immunodeficiency Virus
Shvetsov, IuP; Novikov, VV; Fesenko, EE; Aliushev, FK; Eremin, SM; Markov, IA; Ten, IuA
[Decrease in RNA-dependent DNA polymerase activity of recombinant human immunodeficiency virus reverse transcriptase in bidistilled modified water]
Biofizika
46
379-80
0
Human Immunodeficiency Virus
Andreeva, OI; Efimtseva, EV; Padiukova, NSh; Kochetkov, SN; Mikhaĭlov, SN; Dixon, GB; Karpeĭskiĭ, MIa
[Interaction of HIV-1 reverse transcriptase and bacteriophage T7 RNA polymerase with NTP phosphonate analogs and inorganic pyrophosphate]
Mol Biol (Mosk)
35
844-56
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Human Immunodeficiency Virus
Rigourd, M; Ehresmann, C; Parniak, MA; Ehresmann, B; Marquet, R
Primer unblocking and rescue of DNA synthesis by azidothymidine (AZT)-resistant HIV-1 reverse transcriptase: comparison between initiation and elongation of reverse transcription and between (-) and (+) strand DNA synthesis.
J Biol Chem
277
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2002
Human Immunodeficiency Virus, Terminator
Lu, H; Macosko, J; Habel-Rodriguez, D; Keller, RW; Brozik, JA; Keller, DJ
Closing of the fingers domain generates motor forces in the HIV reverse transcriptase.
J Biol Chem
279
54529-32
2004
Human Immunodeficiency Virus
Roquebert, B; Wirden, M; Simon, A; Deval, J; Katlama, C; Calvez, V; Marcelin, AG
Relationship between mutations in HIV-1 RNase H domain and nucleoside reverse transcriptase inhibitors resistance mutations in naïve and pre-treated HIV infected patients.
J Med Virol
79
207-11
2007
Homo sapiens, Human immunodeficiency virus 1
Garforth, SJ; Domaoal, RA; Lwatula, C; Landau, MJ; Meyer, AJ; Anderson, KS; Prasad, VR
K65R and K65A substitutions in HIV-1 reverse transcriptase enhance polymerase fidelity by decreasing both dNTP misinsertion and mispaired primer extension efficiencies.
J Mol Biol
401
33-44
2010
Human Immunodeficiency Virus
Ditzler, MA; Lange, MJ; Bose, D; Bottoms, CA; Virkler, KF; Sawyer, AW; Whatley, AS; Spollen, W; Givan, SA; Burke, DH
High-throughput sequence analysis reveals structural diversity and improved potency among RNA inhibitors of HIV reverse transcriptase.
Nucleic Acids Res
41
1873-84
2013
Human Immunodeficiency Virus
Corona, A; Meleddu, R; Esposito, F; Distinto, S; Bianco, G; Masaoka, T; Maccioni, E; Menndez-Arias, L; Alcaro, S; Le Grice, SF; Tramontano, E
Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6.
PLoS One
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Human immunodeficiency virus 1
Aeksiri, N; Warakulwit, C; Hannongbua, S; Unajak, S; Choowongkomon, K
Use of Capillary Electrophoresis to Study the Binding Interaction of Aptamers with Wild-Type, K103N, and Double Mutant (K103N/Y181C) HIV-1 RT : Studying the Binding Interaction of Wild-Type, K103N, and Double Mutant (K103N/Y181C) HIV-1 RT with Aptamers by Performing the Capillary Electrophoresis.
Appl Biochem Biotechnol
2016
Human Immunodeficiency Virus
Sanna, C; Rigano, D; Corona, A; Piano, D; Formisano, C; Farci, D; Franzini, G; Ballero, M; Chianese, G; Tramontano, E; Taglialatela-Scafati, O; Esposito, F
Dual HIV-1 reverse transcriptase and integrase inhibitors from Limonium morisianum Arrigoni, an endemic species of Sardinia (Italy).
Nat Prod Res
1-6
2018
Human immunodeficiency virus 1
Corona, A; Onnis, V; Del Vecchio, C; Esposito, F; Cheng, YC; Tramontano, E
2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication.
Molecules
25
2020
Human immunodeficiency virus 1
Eriksson, S; Xu, B; Clayton, DA
Efficient incorporation of anti-HIV deoxynucleotides by recombinant yeast mitochondrial DNA polymerase.
J Biol Chem
270
18929-34
1995
Human Immunodeficiency Virus
Hsieh, JC; Zinnen, S; Modrich, P
Kinetic mechanism of the DNA-dependent DNA polymerase activity of human immunodeficiency virus reverse transcriptase.
J Biol Chem
268
24607-13
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Human Immunodeficiency Virus
Marcus, SL; Smith, SW; Modak, MJ
Reverse transcriptase-associated RNase H activity. II. Inhibition by natural and synthetic RNA.
J Virol
27
576-81
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synthetic RNA
el Dirani-Diab, R; Andreola, ML; Nevinsky, G; Tharaud, D; Barr, PJ; Litvak, S; Tarrago-Litvak, L
Biochemical characterization of the p51 sub-unit of human immunodeficiency virus reverse transcriptase in homo- and heterodimeric recombinant forms of the enzyme.
FEBS Lett
301
23-8
1992
Human Immunodeficiency Virus
Tao, P
[The inhibitory effects of catechin derivatives on the activities of human immunodeficiency virus reverse transcriptase and DNA polymerases]
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
14
334-8
1992
Human Immunodeficiency Virus
Basu, A; Ahluwalia, KK; Basu, S; Modak, MJ
Identification of the primer binding domain in human immunodeficiency virus reverse transcriptase.
Biochemistry
31
616-23
1992
Human Immunodeficiency Virus
Huang, P; Farquhar, D; Plunkett, W
Selective action of 2',3'-didehydro-2',3'-dideoxythymidine triphosphate on human immunodeficiency virus reverse transcriptase and human DNA polymerases.
J Biol Chem
267
2817-22
1992
Homo sapiens, Human Immunodeficiency Virus
Orr, DC; Figueiredo, HT; Mo, CL; Penn, CR; Cameron, JM
DNA chain termination activity and inhibition of human immunodeficiency virus reverse transcriptase by carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine triphosphate.
J Biol Chem
267
4177-82
1992
Human Immunodeficiency Virus
Lederer, H; Schatz, O; May, R; Crespi, H; Darlix, JL; Le Grice, SF; Heumann, H
Domain structure of the human immunodeficiency virus reverse transcriptase.
EMBO J
11
1131-9
1992
Human Immunodeficiency Virus
Reardon, JE
Human immunodeficiency virus reverse transcriptase: steady-state and pre-steady-state kinetics of nucleotide incorporation.
Biochemistry
31
4473-9
1992
Human Immunodeficiency Virus
Sarih-Cottin, L; Bordier, B; Musier-Forsyth, K; Andreola, ML; Barr, PJ; Litvak, S
Preferential interaction of human immunodeficiency virus reverse transcriptase with two regions of primer tRNA(Lys) as evidenced by footprinting studies and inhibition with synthetic oligoribonucleotides.
J Mol Biol
226
1-6
1992
Human Immunodeficiency Virus, Human immunodeficiency virus 1
DeStefano, JJ; Buiser, RG; Mallaber, LM; Fay, PJ; Bambara, RA
Parameters that influence processive synthesis and site-specific termination by human immunodeficiency virus reverse transcriptase on RNA and DNA templates.
Biochim Biophys Acta
1131
270-80
1992
Human Immunodeficiency Virus
Richter-Cook, NJ; Howard, KJ; Cirino, NM; Wöhrl, BM; Le Grice, SF
Interaction of tRNA(Lys-3) with multiple forms of human immunodeficiency virus reverse transcriptase.
J Biol Chem
267
15952-7
1992
Human Immunodeficiency Virus
Condra, JH; Emini, EA; Gotlib, L; Graham, DJ; Schlabach, AJ; Wolfgang, JA; Colonno, RJ; Sardana, VV
Identification of the human immunodeficiency virus reverse transcriptase residues that contribute to the activity of diverse nonnucleoside inhibitors.
Antimicrob Agents Chemother
36
1441-6
1992
Human Immunodeficiency Virus
Mitchell, LL; Cooperman, BS
Active site studies of human immunodeficiency virus reverse transcriptase.
Biochemistry
31
7707-13
1992
Human Immunodeficiency Virus
DeStefano, JJ; Mallaber, LM; Rodriguez-Rodriguez, L; Fay, PJ; Bambara, RA
Requirements for strand transfer between internal regions of heteropolymer templates by human immunodeficiency virus reverse transcriptase.
J Virol
66
6370-8
1992
Human Immunodeficiency Virus
Hart, GJ; Orr, DC; Penn, CR; Figueiredo, HT; Gray, NM; Boehme, RE; Cameron, JM
Effects of (-)-2'-deoxy-3'-thiacytidine (3TC) 5'-triphosphate on human immunodeficiency virus reverse transcriptase and mammalian DNA polymerases alpha, beta, and gamma.
Antimicrob Agents Chemother
36
1688-94
1992
Human Immunodeficiency Virus
Izuta, S; Shimada, N; Kitagawa, M; Suzuki, M; Kojima, K; Yoshida, S
Inhibitory effects of triphosphate derivatives of oxetanocin G and related compounds on eukaryotic and viral DNA polymerases and human immunodeficiency virus reverse transcriptase.
J Biochem (Tokyo)
112
81-7
1992
Human Immunodeficiency Virus
Hao, Z; Cooney, DA; Farquhar, D; Perno, CF; Zhang, K; Masood, R; Wilson, Y; Hartman, NR; Balzarini, J; Johns, DG
Potent DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2',3'-dideoxyuridine-5'-triphosphate.
Mol Pharmacol
37
157-63
1990
Human Immunodeficiency Virus
Bordier, B; Tarrago-Litvak, L; Sallafranque-Andreola, ML; Robert, D; Tharaud, D; Fournier, M; Barr, PJ; Litvak, S; Sarih-Cottin, L
Inhibition of the p66/p51 form of human immunodeficiency virus reverse transcriptase by tRNA(Lys).
Nucleic Acids Res
18
429-36
1990
Human Immunodeficiency Virus
Nakane, H; Ono, K
Differential inhibitory effects of some catechin derivatives on the activities of human immunodeficiency virus reverse transcriptase and cellular deoxyribonucleic and ribonucleic acid polymerases.
Biochemistry
29
2841-5
1990
Human Immunodeficiency Virus
Williams, KJ; Loeb, LA; Fry, M
Synthesis of DNA by human immunodeficiency virus reverse transcriptase is preferentially blocked at template oligo(deoxyadenosine) tracts.
J Biol Chem
265
18682-9
1990
Human Immunodeficiency Virus
Reardon, JE; Miller, WH
Human immunodeficiency virus reverse transcriptase. Substrate and inhibitor kinetics with thymidine 5'-triphosphate and 3'-azido-3'-deoxythymidine 5'-triphosphate.
J Biol Chem
265
20302-7
1990
Human Immunodeficiency Virus
Fernandez-Larsson, R; Patterson, JL
Ribavirin is an inhibitor of human immunodeficiency virus reverse transcriptase.
Mol Pharmacol
38
766-70
1990
Human Immunodeficiency Virus
Robert, D; Sallafranque-Andreola, ML; Bordier, B; Sarih-Cottin, L; Tarrago-Litvak, L; Graves, PV; Barr, PJ; Fournier, M; Litvak, S
Interactions with tRNA(Lys) induce important structural changes in human immunodeficiency virus reverse transcriptase.
FEBS Lett
277
239-42
1990
Human Immunodeficiency Virus
Lloyd, LF; Brick, P; Lou, MZ; Chayen, NE; Blow, DM
Many crystal forms of human immunodeficiency virus reverse transcriptase.
J Mol Biol
217
19-22
1991
Human Immunodeficiency Virus
DeVico, AL; Copeland, TD; Oroszlan, S; Gallo, RC; Sarngadharan, MG
Interaction of C-terminal sequences of human immunodeficiency virus reverse transcriptase with template primer.
J Biol Chem
266
6774-9
1991
Human Immunodeficiency Virus
Tang, X
[Inhibition of human immunodeficiency virus reverse transcriptase in vitro by extracts of Chinese medicinal herbs]
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
12
391-5
1990
Human Immunodeficiency Virus
Tang, X; Chen, H; Zhang, X
Inhibition of human immunodeficiency virus reverse transcriptase by Chinese medicines in vitro.
Proc Chin Acad Med Sci Peking Union Med Coll
5
140-4
1990
Human Immunodeficiency Virus
Tanese, N; Telesnitsky, A; Goff, SP
Abortive reverse transcription by mutants of Moloney murine leukemia virus deficient in the reverse transcriptase-associated RNase H function.
J Virol
65
4387-97
1991
Moloney murine leukemia virus
Reardon, JE; Furfine, ES; Cheng, N
Human immunodeficiency virus reverse transcriptase. Effect of primer length on template-primer binding.
J Biol Chem
266
14128-34
1991
Human Immunodeficiency Virus
De Groot, AS; Clerici, M; Hosmalin, A; Hughes, SH; Barnd, D; Hendrix, CW; Houghten, R; Shearer, GM; Berzofsky, JA
Human immunodeficiency virus reverse transcriptase T helper epitopes identified in mice and humans: correlation with a cytotoxic T cell epitope.
J Infect Dis
164
1058-65
1991
Homo sapiens, Mus sp., Human Immunodeficiency Virus
Prasad, VR; Lowy, I; de los Santos, T; Chiang, L; Goff, SP
Isolation and characterization of a dideoxyguanosine triphosphate-resistant mutant of human immunodeficiency virus reverse transcriptase.
Proc Natl Acad Sci U S A
88
11363-7
1991
Human Immunodeficiency Virus
Furman, PA; Fyfe, JA; St Clair, MH; Weinhold, K; Rideout, JL; Freeman, GA; Lehrman, SN; Bolognesi, DP; Broder, S; Mitsuya, H
Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.
Proc Natl Acad Sci U S A
83
8333-7
1986
Human Immunodeficiency Virus
Cheng, YC; Dutschman, GE; Bastow, KF; Sarngadharan, MG; Ting, RY
Human immunodeficiency virus reverse transcriptase. General properties and its interactions with nucleoside triphosphate analogs.
J Biol Chem
262
2187-9
1987
Human Immunodeficiency Virus
Sano, K; Lee, MH; Morales, F; Nishanian, P; Fahey, J; Detels, R; Imagawa, DT
Antibody that inhibits human immunodeficiency virus reverse transcriptase and association with inability to isolate virus.
J Clin Microbiol
25
2415-7
1987
Human Immunodeficiency Virus
Hizi, A; McGill, C; Hughes, SH
Expression of soluble, enzymatically active, human immunodeficiency virus reverse transcriptase in Escherichia coli and analysis of mutants.
Proc Natl Acad Sci U S A
85
1218-22
1988
Escherichia coli, Human Immunodeficiency Virus
Nakashima, H; Kido, Y; Kobayashi, N; Motoki, Y; Neushul, M; Yamamoto, N
Purification and characterization of an avian myeloblastosis and human immunodeficiency virus reverse transcriptase inhibitor, sulfated polysaccharides extracted from sea algae.
Antimicrob Agents Chemother
31
1524-8
1987
Human Immunodeficiency Virus
St Clair, MH; Richards, CA; Spector, T; Weinhold, KJ; Miller, WH; Langlois, AJ; Furman, PA
3'-Azido-3'-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase.
Antimicrob Agents Chemother
31
1972-7
1987
Human Immunodeficiency Virus
Starnes, MC; Gao, WY; Ting, RY; Cheng, YC
Enzyme activity gel analysis of human immunodeficiency virus reverse transcriptase.
J Biol Chem
263
5132-4
1988
Human Immunodeficiency Virus
Majumdar, C; Abbotts, J; Broder, S; Wilson, SH
Studies on the mechanism of human immunodeficiency virus reverse transcriptase. Steady-state kinetics, processivity, and polynucleotide inhibition.
J Biol Chem
263
15657-65
1988
Human Immunodeficiency Virus
Tanese, N; Prasad, VR; Goff, SP
Structural requirements for bacterial expression of stable, enzymatically active fusion proteins containing the human immunodeficiency virus reverse transcriptase.
DNA
7
407-16
0
Human Immunodeficiency Virus
Prasad, VR; Goff, SP
Linker insertion mutagenesis of the human immunodeficiency virus reverse transcriptase expressed in bacteria: definition of the minimal polymerase domain.
Proc Natl Acad Sci U S A
86
3104-8
1989
Bacteria, insertion sequences, Human Immunodeficiency Virus
Padberg, C; Nowlan, S; Mermer, B
Recombinant polypeptides from the human immunodeficiency virus reverse transcriptase define three epitopes recognized by antibodies in sera from patients with acquired immunodeficiency syndrome.
AIDS Res Hum Retroviruses
5
61-71
1989
Homo sapiens, Human Immunodeficiency Virus
Basu, A; Tirumalai, RS; Modak, MJ
Substrate binding in human immunodeficiency virus reverse transcriptase. An analysis of pyridoxal 5'-phosphate sensitivity and identification of lysine 263 in the substrate-binding domain.
J Biol Chem
264
8746-52
1989
Human Immunodeficiency Virus
White, EL; Parker, WB; Macy, LJ; Shaddix, SC; McCaleb, G; Secrist, JA; Vince, R; Shannon, WM
Comparison of the effect of Carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerases.
Biochem Biophys Res Commun
161
393-8
1989
Homo sapiens, Human Immunodeficiency Virus
Starnes, MC; Cheng, YC
Inhibition of human immunodeficiency virus reverse transcriptase by 2',3'-dideoxynucleoside triphosphates: template dependence, and combination with phosphonoformate.
Virus Genes
2
241-51
1989
Human Immunodeficiency Virus
Sallafranque-Andreola, ML; Robert, D; Barr, PJ; Fournier, M; Litvak, S; Sarih-Cottin, L; Tarrago-Litvak, L
Human immunodeficiency virus reverse transcriptase expressed in transformed yeast cells. Biochemical properties and interactions with bovine tRNALys.
Eur J Biochem
184
367-74
1989
Bos taurus, Human Immunodeficiency Virus, Saccharomyces cerevisiae
DeStefano, JJ
The orientation of binding of human immunodeficiency virus reverse transcriptase on nucleic acid hybrids.
Nucleic Acids Res
23
3901-8
1995
Human Immunodeficiency Virus
Divita, G; Baillon, JG; Rittinger, K; Chermann, JC; Goody, RS
Interface peptides as structure-based human immunodeficiency virus reverse transcriptase inhibitors.
J Biol Chem
270
28642-6
1995
Human Immunodeficiency Virus
Yamaguchi, T; Saneyoshi, M; Shudo, K
Inhibitory effects of 2'-deoxy-L-thymidine 5'-triphosphate on human immunodeficiency virus reverse transcriptase and eukaryotic DNA polymerases.
Nucleic Acids Symp Ser
135-6
1993
Human Immunodeficiency Virus
Kew, Y; Qingbin, S; Prasad, VR
Subunit-selective mutagenesis of Glu-89 residue in human immunodeficiency virus reverse transcriptase. Contribution of p66 and p51 subunits to nucleoside analog sensitivity, divalent cation preference, and steady state kinetic properties.
J Biol Chem
269
15331-6
1994
Human Immunodeficiency Virus
Zinnen, S; Hsieh, JC; Modrich, P
Misincorporation and mispaired primer extension by human immunodeficiency virus reverse transcriptase.
J Biol Chem
269
24195-202
1994
Human Immunodeficiency Virus
Doronin, SV; Dobrikov, MI; Buckle, M; Roux, P; Buc, H; Lavrik, OI
Affinity modification of human immunodeficiency virus reverse transcriptase and DNA template by photoreactive dCTP analogs.
FEBS Lett
354
200-2
1994
Human Immunodeficiency Virus
DeStefano, JJ
Kinetic analysis of the catalysis of strand transfer from internal regions of heteropolymeric RNA templates by human immunodeficiency virus reverse transcriptase.
J Mol Biol
243
558-67
1994
Human Immunodeficiency Virus
Wu, W; Blumberg, BM; Fay, PJ; Bambara, RA
Strand transfer mediated by human immunodeficiency virus reverse transcriptase in vitro is promoted by pausing and results in misincorporation.
J Biol Chem
270
325-32
1995
Human Immunodeficiency Virus
Gudima, SO; Memelova, LV; Borodulin, VB; Pokholok, DK; Mednikov, BM; Tolkachev, ON; Kochetkov, SN
[Kinetic analysis of interaction of human immunodeficiency virus reverse transcriptase with alkaloids]
Mol Biol (Mosk)
28
1308-14
0
Human Immunodeficiency Virus
Moore, PS; Jones, CJ; Mahmood, N; Evans, IG; Goff, M; Cooper, R; Hay, AJ
Anti-(human immunodeficiency virus) activity of polyoxotungstates and their inhibition of human immunodeficiency virus reverse transcriptase.
Biochem J
307 ( Pt 1)
129-34
1995
Human Immunodeficiency Virus
Wöhrl, BM; Tantillo, C; Arnold, E; Le Grice, SF
An expanded model of replicating human immunodeficiency virus reverse transcriptase.
Biochemistry
34
5343-56
1995
Human Immunodeficiency Virus
Rittinger, K; Divita, G; Goody, RS
Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors.
Proc Natl Acad Sci U S A
92
8046-9
1995
Human Immunodeficiency Virus
Kozal, MJ; Shafer, RW; Winters, MA; Katzenstein, DA; Merigan, TC
A mutation in human immunodeficiency virus reverse transcriptase and decline in CD4 lymphocyte numbers in long-term zidovudine recipients.
J Infect Dis
167
526-32
1993
Human Immunodeficiency Virus
Reardon, JE
Human immunodeficiency virus reverse transcriptase. A kinetic analysis of RNA-dependent and DNA-dependent DNA polymerization.
J Biol Chem
268
8743-51
1993
Human Immunodeficiency Virus
DeStefano, JJ; Bambara, RA; Fay, PJ
Parameters that influence the binding of human immunodeficiency virus reverse transcriptase to nucleic acid structures.
Biochemistry
32
6908-15
1993
Human Immunodeficiency Virus
Thimmig, RL; McHenry, CS
Human immunodeficiency virus reverse transcriptase. Expression in Escherichia coli, purification, and characterization of a functionally and structurally asymmetric dimeric polymerase.
J Biol Chem
268
16528-36
1993
Escherichia, Escherichia coli, Human Immunodeficiency Virus
Palaniappan, C; Fuentes, GM; Rodríguez-Rodríguez, L; Fay, PJ; Bambara, RA
Helix structure and ends of RNA/DNA hybrids direct the cleavage specificity of HIV-1 reverse transcriptase RNase H.
J Biol Chem
271
2063-70
1996
Human immunodeficiency virus 1
Kim, B; Hathaway, TR; Loeb, LA
Human immunodeficiency virus reverse transcriptase. Functional mutants obtained by random mutagenesis coupled with genetic selection in Escherichia coli.
J Biol Chem
271
4872-8
1996
Escherichia, Escherichia coli, Human Immunodeficiency Virus
Althaus, IW; Franks, KM; Langley, KB; Kézdy, FJ; Peterson, T; Buxser, SE; Decker, DE; Dolak, LA; Ulrich, RG; Reusser, F
The amphiphilic properties of novenamines determine their activity as inhibitors of HIV-1 RNase H.
Experientia
52
329-35
1996
Human immunodeficiency virus 1
Zakharova, OD; Suturina, OA; Gudima, SO; Pokholok, DK; Iamkovoĭ, VI; Kochetkov, SN; Nevinskiĭ, GA
[Interaction of primers with mutant forms of human immunodeficiency virus reverse transcriptase]
Mol Biol (Mosk)
30
231-40
0
Human Immunodeficiency Virus
Holodniy, M; Katzenstein, D; Mole, L; Winters, M; Merigan, T
Human immunodeficiency virus reverse transcriptase codon 215 mutations diminish virologic response to didanosine-zidovudine therapy in subjects with non-syncytium-inducing phenotype.
J Infect Dis
174
854-7
1996
Human Immunodeficiency Virus
Hizi, A; Kamath-Loeb, AS; Rose, KD; Loeb, LA
Mutagenesis by human immunodeficiency virus reverse transcriptase: incorporation of O6-methyldeoxyguanosine triphosphate.
Mutat Res
374
41-50
1997
Human Immunodeficiency Virus
Shcherbik, NV; Khodyreva, SN; Vlasov, VA; Dobrikov, MI; Dymshits, GM; Lavrik, OI
[Photoaffinity modification of human immunodeficiency virus reverse transcriptase with an analog of deoxyuridine-5'-triphosphate, containing an arylazide group]
Mol Biol (Mosk)
31
344-52
0
Human Immunodeficiency Virus
Timofeeva, OA; Riabinin, VA; Siniakov, AN; Zakharova, OD; Iamkovoĭ, VI; Tarrago-Litvak, L; Litvak, S; Nevinskiĭ, GA
[Inhibition of the polymerization reaction, catalyzed by human immunodeficiency virus reverse transcriptase using model substrates by derivatives of oligo-1,3-thiazolecarboxamides]
Mol Biol (Mosk)
31
359-65
0
Human Immunodeficiency Virus
Zakharova, OD; Mart'ianov, IV; Timofeeva, OA; Sottofattori, E; Pyshnyĭ, DV; Balbi, A; Litvak, S; Tarrago-Litvak, L; Nevinskiĭ, GA
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A Single Dose of a MIV-150/Zinc Acetate Gel Provides 24?h of Protection Against Vaginal Simian Human Immunodeficiency Virus Reverse Transcriptase Infection, with More Limited Protection Rectally 8-24?h After Gel Use.
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Human immunodeficiency virus 1
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AIDS Res Hum Retroviruses
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Human Immunodeficiency Virus, Viruses
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Human immunodeficiency virus 1
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Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication.
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Human immunodeficiency virus 1
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Multi-target activity of Hemidesmus indicus decoction against innovative HIV-1 drug targets and characterization of Lupeol mode of action.
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Human immunodeficiency virus 1
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Hepatitis B virus, Human Immunodeficiency Virus
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Human Immunodeficiency Virus
Ko, YJ; Choi, WJ; Jun, JH; Zhao, LX; Jeong, LS
Synthesis and conformational analysis of novel 2',3'-didehydo-2',3'-dideoxy-4'-selenonucleosides.
Nucleic Acids Symp Ser (Oxf)
555-6
2008
Human Immunodeficiency Virus
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