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Reference on EC 3.1.26.13 - retroviral ribonuclease H

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Roth, M.J.; Tanese, N.; Goff, S.P.
Purification and characterization of murine retroviral reverse transcriptase expressed in Escherichia coli
J. Biol. Chem.
260
9326-9335
1985
Moloney murine leukemia virus
Manually annotated by BRENDA team
Rausch, J.W.; Lener, D.; Miller, J.T.; Julias, J.G.; Hughes, S.H.; Le Grice, S.F.J.
Altering the RNase H primer grip of human immunodeficiency virus reverse transcriptase modifies cleavage specificity
Biochemistry
41
4856-4865
2002
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Lener, D.; Budihas, S.R.; Le Grice, S.F.J.
Mutating conserved residues in the ribonuclease H domain of Ty3 reverse transcriptase affects specialized cleavage events
J. Biol. Chem.
277
26486-26495
2002
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Sevilya, Z.; Loya, S.; Hughes, S.H.; Hizi, A.
The ribonuclease H activity of the reverse transcriptases of human immunodeficiency viruses type 1 and type 2 is affected by the thumb subdomain of the small protein subunits
J. Mol. Biol.
311
957-971
2001
Human immunodeficiency virus 1, Human immunodeficiency virus 2, Human immunodeficiency virus 2 D-194, Human immunodeficiency virus 2 ROD
Manually annotated by BRENDA team
Sevilya, Z.; Loya, S.; Duvshani, A.; Adir, N.; Hizi, A.
Mutagenesis of cysteine 280 of the reverse transcriptase of human immunodeficiency virus type-1: The effects on the ribonuclease H activity
J. Mol. Biol.
327
19-30
2003
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Schultz, S.J.; Zhang, M.; Champoux, J.J.
Sequence, distance, and accessibility are determinants of 5'-end-directed cleavages by retroviral RNases H
J. Biol. Chem.
281
1943-1955
2006
Human immunodeficiency virus 1, Moloney murine leukemia virus
Manually annotated by BRENDA team
Schultz, S.J.; Zhang, M.; Champoux, J.J.
Recognition of internal cleavage sites by retroviral RNases H
J. Mol. Biol.
344
635-652
2004
Human immunodeficiency virus 1, Moloney murine leukemia virus
Manually annotated by BRENDA team
Brehm, J.H.; Mellors, J.W.; Sluis-Cremer, N.
Mechanism by which a glutamine to leucine substitution at residue 509 in the ribonuclease H domain of HIV-1 reverse transcriptase confers zidovudine resistance
Biochemistry
47
14020-14027
2008
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Fuji, H.; Urano, E.; Futahashi, Y.; Hamatake, M.; Tatsumi, J.; Hoshino, T.; Morikawa, Y.; Yamamoto, N.; Komano, J.
Derivatives of 5-nitrofuran-2-carboxylic acid carbamoyl methyl ester inhibit RNase H activity associated with HIV-1 reverse transcriptase
J. Med. Chem.
52
1380-1387
2009
Human immunodeficiency virus 1, Moloney murine leukemia virus
Manually annotated by BRENDA team
Waters, J.; ONeal, W.; White, K.; Wakeford, C.; Lansdon, E.; Harris, J.; Svarovskaia, E.; Miller, M.; Borroto-Esoda, K.
Mutations in the thumb-connection and RNase H domain of HIV type-1 reverse transcriptase of antiretroviral treatment-experienced patients
Antivir. Ther. (Lond. )
14
231-239
2009
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Allen, S.; Krawczyk, S.; McGee, L.; Bischofberger, N.; Mulato, A.; Cherrington, J.
Inhibition of HIV-1 RNase H activity by nucleotide dimers and monomers
Antiviral Chem. Chemother.
7
37-45
1996
Human immunodeficiency virus 1, Moloney murine leukemia virus
-
Manually annotated by BRENDA team
Mizrahi, V.
Analysis of the ribonuclease H activity of HIV-1 reverse transcriptase using RNA-DNA hybrid substrates derived from the gag region of HIV-1
Biochemistry
28
9088-9094
1989
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Furfine, E.S.; Reardon, J.E.
Human immunodeficiency virus reverse transcriptase ribonuclease H: specificity of tRNA(Lys3)-primer excision
Biochemistry
30
7041-7046
1991
Avian myeloblastosis virus, Human Immunodeficiency Virus, Moloney murine leukemia virus
Manually annotated by BRENDA team
Peliska, J.A.; Balasubramanian, S.; Giedroc, D.P.; Benkovic, S.J.
Recombinant HIV-1 nucleocapsid protein accelerates HIV-1 reverse transcriptase catalyzed DNA strand transfer reactions and modulates RNase H activity
Biochemistry
33
13817-13823
1994
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Cirino, N.M.; Cameron, C.E.; Smith, J.S.; Rausch, J.W.; Roth, M.J.; Benkovic, S.J.; Le Grice, S.F.
Divalent cation modulation of the ribonuclease functions of human immunodeficiency virus reverse transcriptase
Biochemistry
34
9936-9943
1995
Human Immunodeficiency Virus
Manually annotated by BRENDA team
Ghosh, M.; Williams, J.; Powell, M.D.; Levin, J.G.; Le Grice, S.F.
Mutating a conserved motif of the HIV-1 reverse transcriptase palm subdomain alters primer utilization
Biochemistry
36
5758-5768
1997
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Gabbara, S.; Davis, W.R.; Hupe, L.; Hupe, D.; Peliska, J.A.
Inhibitors of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase
Biochemistry
38
13070-13076
1999
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Davis, W.R.; Tomsho, J.; Nikam, S.; Cook, E.M.; Somand, D.; Peliska, J.A.
Inhibition of HIV-1 reverse transcriptase-catalyzed DNA strand transfer reactions by 4-chlorophenylhydrazone of mesoxalic acid
Biochemistry
39
14279-14291
2000
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Starnes, M.; Cheng, Y.
Human immunodeficiency virus reverse transcriptase-associated RNase H activity
J. Biol. Chem.
264
7073-7077
1989
Human Immunodeficiency Virus
Manually annotated by BRENDA team
Cirino, N.M.; Kalayjian, R.C.; Jentoft, J.E.; Le Grice, S.F.
Fluorimetric analysis of recombinant p15 HIV-1 ribonuclease H
J. Biol. Chem.
268
14743-14749
1993
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Volkmann, S.; Wohrl, B.; Tisdale, M.; Moelling, K.
Enzymatic analysis of two HIV-1 reverse transcriptase mutants with mutations in carboxyl-terminal amino acid residues conserved among retroviral ribonucleases H
J. Biol. Chem.
268
2674-2683
1993
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Ghosh, M.; Howard, K.J.; Cameron, C.E.; Benkovic, S.J.; Hughes, S.H.; Le Grice, S.F.
Truncating alpha-helix E of p66 human immunodeficiency virus reverse transcriptase modulates RNase H function and impairs DNA strand transfer
J. Biol. Chem.
270
7068-7076
1995
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Rausch, J.W.; Le Grice, S.F.J.
Substituting a conserved residue of ribonuclease H domain alters substrate hydrolysis by retroviral reverse transcriptase
J. Biol. Chem.
272
8602-8610
1997
Human Immunodeficiency Virus
Manually annotated by BRENDA team
Misra, H.; Pandey, P.; Pandey, V.
An enzymatically active chimeric HIV-1 reverse transcriptase (RT) with the RNase-H domain of murine leukemia virus RT exists as a monomer
J. Biol. Chem.
273
9785-9789
1998
murine leukemia virus
Manually annotated by BRENDA team
Schultz, S.J.; Zhang, M.; Kelleher, C.D.; Champoux, J.J.
Analysis of plus-strand primer selection, removal, and reutilization by retroviral reverse transcriptases
J. Biol. Chem.
275
32299-32309
2000
Moloney murine leukemia virus
Manually annotated by BRENDA team
Gao, H.; Sarafianos, S.; Arnold, E.; Hughes, S.
Similarities and differences in the RNase H activities of human immunodeficiency virus type 1 reverse transcriptase and Moloney murine leukemia virus reverse transcriptase
J. Mol. Biol.
294
1097-1113
1999
Human immunodeficiency virus 1, Moloney murine leukemia virus
Manually annotated by BRENDA team
Moelling, K.; Schulze, T.; Diringer, H.
Inhibition of human immunodeficiency virus type 1 RNase H by sulfated polyanions
J. Virol.
63
5489-5491
1989
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Fu, T.; Taylor, J.
When retroviral reverse transcriptases reach the end of their RNA templates
J. Virol.
66
4271-4278
1992
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Brincat, J.L.; Pfeiffer, J.K.; Telesnitsky, A.
RNase H activity is required for high-frequency repeat deletion during Moloney murine leukemia virus replication
J. Virol.
76
88-95
2002
Moloney murine leukemia virus
Manually annotated by BRENDA team
Nikolenko, G.; Palmer, S.; Maldarelli, F.; Mellors, J.; Coffin, J.; Pathak, V.
Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: Balance between RNase H activity and nucleotide excision
Proc. Natl. Acad. Sci. USA
102
2093-2098
2005
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Julias, J.; McWilliams, M.; Sarafianos, S.; Arnold, E.; Hughes, S.
Mutations in the RNase H domain of HIV-1 reverse transcriptase affect the initiation of DNA synthesis and the specificity of RNase H cleavage in vivo
Proc. Natl. Acad. Sci. USA
99
9515-9520
2002
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Goedken, E.R.; Marqusee, S.
Metal binding and activation of the ribonuclease H domain from Moloney murine leukemia virus
Protein Eng.
12
975-980
1999
Moloney murine leukemia virus
Manually annotated by BRENDA team
Kern, G.; Handel, T.; Marqusee, S.
Characterization of a folding intermediate from HIV-1 ribonuclease H
Protein Sci.
7
2164-2174
1998
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Temiz, N.; Bahar, I.
Inhibitor binding alters the directions of domain motions in HIV-1 reverse transcriptase
Proteins Struct. Funct. Genet.
49
61-70
2002
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Davies II, J.; Hostomska, Z.; Hostomsky, Z.; Jordan, S.; Matthews, D.
Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase
Science
252
88-95
1991
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Jones, F.D.; Hughes, S.H.
In vitro analysis of the effects of mutations in the G-tract of the human immunodeficiency virus type 1 polypurine tract on RNase H cleavage specificity
Virology
360
341-349
2007
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Hachiya, A.; Shimane, K.; Sarafianos, S.G.; Kodama, E.N.; Sakagami, Y.; Negishi, F.; Koizumi, H.; Gatanaga, H.; Matsuoka, M.; Takiguchi, M.; Oka, S.
Clinical relevance of substitutions in the connection subdomain and RNase H domain of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naive patients
Antiviral Res.
82
115-121
2009
Human immunodeficiency virus 1 (P03366)
Manually annotated by BRENDA team
Seckler, J.; Howard, K.; Barkley, M.; Wintrode, P.
Solution structural dynamics of HIV-1 reverse transcriptase heterodimer
Biochemistry
48
7646-7655
2009
Human immunodeficiency virus 1 (P03366)
Manually annotated by BRENDA team
Di Grandi, M.; Olson, M.; Prashad, A.S.; Bebernitz, G.; Luckay, A.; Mullen, S.; Hu, Y.; Krishnamurthy, G.; Pitts, K.; OConnell, J.
Small molecule inhibitors of HIV RT Ribonuclease H
Bioorg. Med. Chem. Lett.
20
398-402
2010
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Mizuno, M.; Yasukawa, K.; Inouye, K.
Insight into the mechanism of the stabilization of Moloney murine leukaemia virus reverse transcriptase by eliminating RNase H activity
Biosci. Biotechnol. Biochem.
74
440-442
2010
Moloney murine leukemia virus
Manually annotated by BRENDA team
Kharlamova, T.
Synthesis of phenacyl derivatives of frangula-emodin and their HIV-1 RNase H activity
Chem. Nat. Compd.
45
500-502
2009
Human immunodeficiency virus 1
-
Manually annotated by BRENDA team
Kirschberg, T.A.; Balakrishnan, M.; Squires, N.H.; Barnes, T.; Brendza, K.M.; Chen, X.; Eisenberg, E.J.; Jin, W.; Kutty, N.; Leavitt, S.; Liclican, A.; Liu, Q.; Liu, X.; Mak, J.; Perry, J.K.; Wang, M.; Watkins, W.J.; Lansdon, E.B.
RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information
J. Med. Chem.
52
5781-5784
2009
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Esposito, F.; Fanti, V.; Marzeddu, R.; Randaccio, P.; Tramontano, E.; Zinzula, L.
Validation of a computed radiography device to monitor the HIV-1 RNase H activity
Nucl. Instrum. Meth. Phys. Res. A
607
226-228
2009
Human immunodeficiency virus 1
-
Manually annotated by BRENDA team
Wahba, A.S.; Esmaeili, A.; Damha, M.J.; Hudson, R.H.
A single-label phenylpyrrolocytidine provides a molecular beacon-like response reporting HIV-1 RT RNase H activity
Nucleic Acids Res.
38
1048-1056
2010
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Himmel, D.M.; Maegley, K.A.; Pauly, T.A.; Bauman, J.D.; Das, K.; Dharia, C.; Clark, A.D.; Ryan, K.; Hickey, M.J.; Love, R.A.; Hughes, S.H.; Bergqvist, S.; Arnold, E.
Structure of HIV-1 reverse transcriptase with the inhibitor beta-thujaplicinol bound at the RNase H active site
Structure
17
1625-1635
2009
Human immunodeficiency virus 1 (P03366)
Manually annotated by BRENDA team
Talele, T.; Upadhyay, A.; Pandey, V.
Influence of the RNase H domain of retroviral reverse transcriptases on the metal specificity and substrate selection of their polymerase domains
Virol. J.
6
159-170
2009
Human immunodeficiency virus 1, Moloney murine leukemia virus
Manually annotated by BRENDA team
Xu, H.; Quan, Y.; Schader, S.; Oliveira, M.; Bar-Magen, T.; Wainberg, M.
The M230L nonnucleoside reverse transcriptase inhibitor resistance mutation in HIV-1 reverse transcriptase impairs enzymatic function and viral replicative capacity
Antimicrob. Agents Chemother.
54
2401-2408
2010
Human immunodeficiency virus 1, Human immunodeficiency virus 1 HXB2
Manually annotated by BRENDA team
Farias, R.V.; Vargas, D.A.; Castillo, A.E.; Valenzuela, B.; Cote, M.L.; Roth, M.J.; Leon, O.
Expression of an Mg2+-dependent HIV-1 RNase H construct for drug screening
Antimicrob. Agents Chemother.
55
4735-4741
2011
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Yanagita, H.; Urano, E.; Matsumoto, K.; Ichikawa, R.; Takaesu, Y.; Ogata, M.; Murakami, T.; Wu, H.; Chiba, J.; Komano, J.; Hoshino, T.
Structural and biochemical study on the inhibitory activity of derivatives of 5-nitro-furan-2-carboxylic acid for RNase H function of HIV-1 reverse transcriptase
Bioorg. Med. Chem.
19
816-825
2011
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Kumar, A.
Binding of dumbbell oligonucleotides to MoMuLV reverse transcriptase: inhibitory properties of RNase H activity
E-J. Chem.
7
701-708
2010
Moloney murine leukemia virus
-
Manually annotated by BRENDA team
Billamboz, M.; Bailly, F.; Lion, C.; Calmels, C.; Andreola, M.L.; Witvrouw, M.; Christ, F.; Debyser, Z.; De Luca, L.; Chimirri, A.; Cotelle, P.
2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4
Eur. J. Med. Chem.
46
535-546
2011
Human Immunodeficiency Virus
Manually annotated by BRENDA team
Esposito, F.; Kharlamova, T.; Distinto, S.; Zinzula, L.; Cheng, Y.C.; Dutschman, G.; Floris, G.; Markt, P.; Corona, A.; Tramontano, E.
Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases
FEBS J.
278
1444-1457
2011
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Biondi, M.J.; Beilhartz, G.L.; McCormick, S.; Goette, M.
N348I in HIV-1 reverse transcriptase can counteract the nevirapine-mediated bias toward RNase H cleavage during plus-strand initiation
J. Biol. Chem.
285
26966-26975
2010
Human immunodeficiency virus 1, Human immunodeficiency virus 1 HXB-2
Manually annotated by BRENDA team
Billamboz, M.; Bailly, F.; Lion, C.; Touati, N.; Vezin, H.; Calmels, C.; Andreola, M.; Christ, F.; Debyser, Z.; Cotelle, P.
Magnesium chelating 2-hydroxyisoquinoline-1,3(2H, 4H)-diones, as inhibitors of HIV-1 integrase and/or the HIV-1 reverse transcriptase ribonuclease H domain: Discovery of a novel selective inhibitor of the ribonuclease H function
J. Med. Chem.
54
1812-1824
2011
Moloney murine leukemia virus
Manually annotated by BRENDA team
Chung, S.; Himmel, D.; Jiang, J.; Wojtak, K.; Bauman, J.; Rausch, J.; Wilson, J.; Beutler, J.; Thomas, C.; Arnold, E.; Le Grice, S.
Synthesis, activity, and structural analysis of novel alpha-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H
J. Med. Chem.
54
4462-4473
2011
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Su, H.P.; Yan, Y.; Prasad, G.S.; Smith, R.F.; Daniels, C.L.; Abeywickrema, P.D.; Reid, J.C.; Loughran, H.M.; Kornienko, M.; Sharma, S.; Grobler, J.A.; Xu, B.; Sardana, V.; Allison, T.J.; Williams, P.D.; Darke, P.L.; Hazuda, D.J.; Munshi, S.
Structural basis for the inhibition of RNase H activity of HIV-1 reverse transcriptase by RNase H active site-directed inhibitors
J. Virol.
84
7625-7633
2010
Human immunodeficiency virus 1 (P0C6F2), Human immunodeficiency virus 1 HXB2 (P0C6F2)
Manually annotated by BRENDA team
Wang, J.; Bambara, R.A.; Demeter, L.M.; Dykes, C.
Reduced fitness in cell culture of HIV-1 with nonnucleoside reverse transcriptase inhibitor-resistant mutations correlates with relative levels of reverse transcriptase content and RNase H activity in virions
J. Virol.
84
9377-9389
2010
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Radzvilavicius, T.; Lagunavicius, A.
Selective inactivation of M-MuLV RT RNase H activity by site-directed PEGylation: an improved ability to synthesize long cDNA molecules
New Biotechnol.
29
285-292
2012
Moloney murine leukemia virus
Manually annotated by BRENDA team
Lu, M.; Ngo, W.; Mei, Y.; Munshi, V.; Burlein, C.; Loughran, M.; Williams, P.; Hazuda, D.; Miller, M.; Grobler, J.; Diamond, T.; Lai, M.
Purification of untagged HIV-1 reverse transcriptase by affinity chromatography
Protein Expr. Purif.
71
231-239
2010
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Delviks-Frankenberry, K.A.; Nikolenko, G.N.; Pathak, V.K.
The connection between HIV drug resistance and RNase H
Viruses
2
1476-1503
2010
Human immunodeficiency virus 1, Human immunodeficiency virus 1 HXB2
Manually annotated by BRENDA team
Singh, K.; Marchand, B.; Kirby, K.; Michailidis, E.; Sarafianos, S.
Structural aspects of drug resistance and inhibition of HIV-1 reverse transcriptase
Viruses
2
606-638
2010
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Beilhartz, G.; Goette, M.
HIV-1 ribonuclease H: structure, catalytic mechanism and inhibitors
Viruses
2
900-926
2010
Human immunodeficiency virus 1, Human immunodeficiency virus 2
Manually annotated by BRENDA team
Sarafianos, S.G.; Das, K.; Tantillo, C.; Clark, A.D., Jr.; Ding, J.; Whitcomb, J.M.; Boyer, P.L.; Hughes, S.H.; Arnold, E.
Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA
EMBO J.
20
1449-1461
2001
Human immunodeficiency virus 1 (P03366)
Manually annotated by BRENDA team
Broecker, F.; Andrae, K.; Moelling, K.
Premature activation of the HIV RNase H drives the virus into suicide: a novel microbicide?
AIDS Res. Hum. Retroviruses
28
1397-1403
2012
Human Immunodeficiency Virus
Manually annotated by BRENDA team
Corona, A.; Di Leva, F.S.; Thierry, S.; Pescatori, L.; Cuzzucoli Crucitti, G.; Subra, F.; Delelis, O.; Esposito, F.; Rigogliuso, G.; Costi, R.; Cosconati, S.; Novellino, E.; Di Santo, R.; Tramontano, E.
Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by diketo acid derivatives
Antimicrob. Agents Chemother.
58
6101-6110
2014
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Muchiri, J.M.; Li, D.; Dykes, C.; Bambara, R.A.
Efavirenz stimulates HIV-1 reverse transcriptase RNase H activity by a mechanism involving increased substrate binding and secondary cleavage activity
Biochemistry
52
4981-4990
2013
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Ilina, T.; Labarge, K.; Sarafianos, S.G.; Ishima, R.; Parniak, M.A.
Inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H activity
Biology
1
521-541
2012
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Velthuisen, E.J.; Johns, B.A.; Gerondelis, P.; Chen, Y.; Li, M.; Mou, K.; Zhang, W.; Seal, J.W.; Hightower, K.E.; Miranda, S.R.; Brown, K.; Leesnitzer, L.
Pyridopyrimidinone inhibitors of HIV-1 RNase H
Eur. J. Med. Chem.
83
609-616
2014
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Corona, A.; Masaoka, T.; Tocco, G.; Tramontano, E.; Le Grice, S.F.
Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase
Future Med. Chem.
5
2127-2139
2013
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Beilhartz, G.L.; Ngure, M.; Johns, B.A.; DeAnda, F.; Gerondelis, P.; Goette, M.
Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation
J. Biol. Chem.
289
16270-16277
2014
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Costi, R.; Metifiot, M.; Chung, S.; Cuzzucoli Crucitti, G.; Maddali, K.; Pescatori, L.; Messore, A.; Madia, V.N.; Pupo, G.; Scipione, L.; Tortorella, S.; Di Leva, F.S.; Cosconati, S.; Marinelli, L.; Novellino, E.; Le Grice, S.F.; Corona, A.; Pommier, Y.; Marchand, C.; Di Santo, R.
Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase
J. Med. Chem.
57
3223-3234
2014
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Himmel, D.M.; Myshakina, N.S.; Ilina, T.; Van Ry, A.; Ho, W.C.; Parniak, M.A.; Arnold, E.
Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNase H domain of HIV-1 reverse transcriptase and structure-activity analysis of inhibitor analogs
J. Mol. Biol.
426
2617-2631
2014
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Zheng, X.; Mueller, G.A.; DeRose, E.F.; London, R.E.
Metal and ligand binding to the HIV-RNase H active site are remotely monitored by Ile556
Nucleic Acids Res.
40
10543-10553
2012
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Alvarez, M.; Barrioluengo, V.; Afonso-Lehmann, R.N.; Menendez-Arias, L.
Altered error specificity of RNase H-deficient HIV-1 reverse transcriptases during DNA-dependent DNA synthesis
Nucleic Acids Res.
41
4601-4612
2013
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Zheng, X.; Pedersen, L.C.; Gabel, S.A.; Mueller, G.A.; Cuneo, M.J.; DeRose, E.F.; Krahn, J.M.; London, R.E.
Selective unfolding of one ribonuclease H domain of HIV reverse transcriptase is linked to homodimer formation
Nucleic Acids Res.
42
5361-5377
2014
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Das, K.; Martinez, S.E.; Bandwar, R.P.; Arnold, E.
Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage
Nucleic Acids Res.
42
8125-8137
2014
Human immunodeficiency virus 1 (P03366)
Manually annotated by BRENDA team
Corona, A.; Desantis, J.; Massari, S.; Distinto, S.; Masaoka, T.; Sabatini, S.; Esposito, F.; Manfroni, G.; Maccioni, E.; Cecchetti, V.; Pannecouque, C.; Le Grice, S.; Tramontano, E.; Tabarrini, O.
Studies on cycloheptathiophene-3-carboxamide derivatives as allosteric HIV-1 ribonuclease H inhibitors
ChemMedChem
11
1709-1720
2016
Human immunodeficiency virus type 1 group M subtype B (P03366), Human immunodeficiency virus type 1 group M subtype B BH10 (P03366)
Manually annotated by BRENDA team
Kankanala, J.; Kirby, K.A.; Huber, A.D.; Casey, M.C.; Wilson, D.J.; Sarafianos, S.G.; Wang, Z.
Design, synthesis and biological evaluations of N-hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H
Eur. J. Med. Chem.
141
149-161
2017
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Wang, L.; Tang, J.; Huber, A.D.; Casey, M.C.; Kirby, K.A.; Wilson, D.J.; Kankanala, J.; Xie, J.; Parniak, M.A.; Sarafianos, S.G.; Wang, Z.
6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity
Eur. J. Med. Chem.
156
652-665
2018
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Wang, L.; Tang, J.; Huber, A.D.; Casey, M.C.; Kirby, K.A.; Wilson, D.J.; Kankanala, J.; Parniak, M.A.; Sarafianos, S.G.; Wang, Z.
6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H
Eur. J. Med. Chem.
156
680-691
2018
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Tang, J.; Do, H.T.; Huber, A.D.; Casey, M.C.; Kirby, K.A.; Wilson, D.J.; Kankanala, J.; Parniak, M.A.; Sarafianos, S.G.; Wang, Z.
Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H tolerance of a nonflexible linker
Eur. J. Med. Chem.
166
390-399
2019
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Moelling, K.; Broecker, F.; Russo, G.; Sunagawa, S.
RNase H as gene modifier, driver of evolution and antiviral defense
Front. Microbiol.
8
1745
2017
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Li, A.; Li, J.; Johnson, K.A.
HIV-1 reverse transcriptase polymerase and RNase H (ribonuclease H) active sites work simultaneously and independently
J. Biol. Chem.
291
26566-26585
2016
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Luczkowiak, J.; Matamoros, T.; Menendez-Arias, L.
Template-primer binding affinity and RNase H cleavage specificity contribute to the strand transfer efficiency of HIV-1 reverse transcriptase
J. Biol. Chem.
293
13351-13363
2018
Human immunodeficiency virus type 1 group O subtype B, Human immunodeficiency virus type 1 group M subtype B (P03366), Human immunodeficiency virus type 1 group O subtype B ESP49, Human immunodeficiency virus type 1 group M subtype B BH10 (P03366)
Manually annotated by BRENDA team
Tang, J.; Liu, F.; Nagy, E.; Miller, L.; Kirby, K.A.; Wilson, D.J.; Wu, B.; Sarafianos, S.G.; Parniak, M.A.; Wang, Z.
3-Hydroxypyrimidine-2,4-diones as selective active site inhibitors of HIV reverse transcriptase-associated RNase H design, synthesis, and biochemical evaluations
J. Med. Chem.
59
2648-2659
2016
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Oda, M.; Xi, Z.; Inaba, S.; Slack, R.; Ishima, R.
Binding thermodynamics of metal ions to HIV-1 ribonuclease H domain
J. Therm. Anal. Calorim.
135
2647-2653
2019
Human immunodeficiency virus type 1 group M subtype B, Human immunodeficiency virus type 1 group M subtype B BH10
Manually annotated by BRENDA team
Boso, G.; Oervell, C.; Somia, N.
The nature of the N-terminal amino acid residue of HIV-1 RNase H is critical for the stability of reverse transcriptase in viral particles
J. Virol.
89
1286-1297
2015
Human immunodeficiency virus 1
-
Manually annotated by BRENDA team
Boyer, P.L.; Smith, S.J.; Zhao, X.Z.; Das, K.; Gruber, K.; Arnold, E.; Burke, T.R.; Hughes, S.H.
Developing and evaluating inhibitors against the RNase H active site of HIV-1 reverse transcriptase
J. Virol.
92
e02203-17
2018
Human immunodeficiency virus type 1 group M subtype B (P03366), Human immunodeficiency virus type 1 group M subtype B BH10 (P03366)
Manually annotated by BRENDA team
Murelli, R.P.; D'Erasmo, M.P.; Hirsch, D.R.; Meck, C.; Masaoka, T.; Wilson, J.A.; Zhang, B.; Pal, R.K.; Gallicchio, E.; Beutler, J.A.; Le Grice, S.F.
Synthetic alpha-hydroxytropolones as inhibitors of HIV reverse transcriptase ribonuclease H activity
MedChemComm
7
1783-1788
2016
Human immunodeficiency virus 1 (P05959), Human immunodeficiency virus 1, Human immunodeficiency virus 1 RF (P05959)
Manually annotated by BRENDA team
Permanasari, E.D.; Yasukawa, K.; Kanaya, S.
Enzymatic activities of RNase H domains of HIV-1 reverse transcriptase with substrate binding domains of bacterial RNases H1 and H2
Mol. Biotechnol.
57
526-538
2015
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Ngoutane Mfopa, A.; Corona, A.; Eloh, K.; Tramontano, E.; Frau, A.; Boyom, F.F.; Caboni, P.; Tocco, G.
Uvaria angolensis as a promising source of inhibitors of HIV-1 RT-associated RNA-dependent DNA polymerase and RNase H functions
Nat. Prod. Res.
32
640-647
2018
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Zheng, X.; Pedersen, L.C.; Gabel, S.A.; Mueller, G.A.; DeRose, E.F.; London, R.E.
Unfolding the HIV-1 reverse transcriptase RNase H domain - how to lose a molecular tug-of-war
Nucleic Acids Res.
44
1776-1788
2016
Human immunodeficiency virus 1 (P04585), Human immunodeficiency virus 1
Manually annotated by BRENDA team
Figiel, M.; Krepl, M.; Poznanski, J.; Golab, A.; Sponer, J.; Nowotny, M.
Coordination between the polymerase and RNase H activity of HIV-1 reverse transcriptase
Nucleic Acids Res.
45
3341-3352
2017
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Yang, F.; Zheng, G.; Fu, T.; Li, X.; Tu, G.; Li, Y.H.; Yao, X.; Xue, W.; Zhu, F.
Prediction of the binding mode and resistance profile for a dual-target pyrrolyl diketo acid scaffold against HIV-1 integrase and reverse-transcriptase-associated ribonuclease H
Phys. Chem. Chem. Phys.
20
23873-23884
2018
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Slack, R.L.; Spiriti, J.; Ahn, J.; Parniak, M.A.; Zuckerman, D.M.; Ishima, R.
Structural integrity of the ribonuclease H domain in HIV-1 reverse transcriptase
Proteins
83
1526-1538
2015
Human immunodeficiency virus 1 (P03366)
Manually annotated by BRENDA team
Herzig, E.; Hizi, A.
The importance of glutamine 294 that affects the ribonuclease H activity of the reverse transcriptase of HIV-2 to viral replication
Virology
483
13-20
2015
Human Immunodeficiency Virus
Manually annotated by BRENDA team
Ngcapu, S.; Theys, K.; Libin, P.; Marconi, V.C.; Sunpath, H.; Ndungu, T.; Gordon, M.L.
Characterization of nucleoside reverse transcriptase inhibitor-associated mutations in the RNase H region of HIV-1 subtype C infected individuals
Viruses
9
330-339
2017
Human immunodeficiency virus type 1 subtype C
Manually annotated by BRENDA team