Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 3.1.26.11 - tRNase Z and Organism(s) Homo sapiens and UniProt Accession Q9H777

for references in articles please use BRENDA:EC3.1.26.11
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.26 Endoribonucleases producing 5'-phosphomonoesters
                3.1.26.11 tRNase Z
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Homo sapiens
UNIPROT: Q9H777 not found.
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule
Synonyms
elac2, trnase z, rnase z, rnase bn, trnase zl, 3' trnase, 3'-trnase, trnase zs, trna 3' processing endoribonuclease, rnase zs1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
(tRNase) Z
-
-
3 tRNase
-
-
-
-
3' tRNase
-
-
3'-tRNA processing endoribonuclease
-
-
-
-
3'-tRNase
-
-
Elac1
-
-
ELAC2
long form of 3' tRNase
-
-
long form of tRNA 3' processing endoribonuclease
-
-
long form of tRNase Z
-
-
nuclease, transfer ribonucleate maturation 3'-endoribo-(9CI)
-
-
-
-
pre-tRNA processing endoribonuclease
-
-
-
-
precursor tRNA 3'-end processing endoribonuclease
-
-
-
-
RNase Z
transfer RNA maturation endonuclease
-
-
-
-
tRNA 3 endonuclease
-
-
-
-
tRNA 3' processing endoribonuclease
-
-
-
-
tRNA 3'-processing enzyme tRNase Z
-
-
tRNA precursor-processing endoribonuclease
-
-
-
-
tRNase Z
tRNase ZL
tRNase ZS
tRnaseZL
-
-
tRnaseZS
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
hydrolysis of phosphoric ester
CAS REGISTRY NUMBER
COMMENTARY hide
98148-84-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
mt-pre-tRNAArg + H2O
mt-tRNAArg + 3'-leader of tRNA
show the reaction diagram
-
-
-
-
?
mt-pre-tRNAGlu + H2O
mt-tRNAGlu + 3'-leader of tRNA
show the reaction diagram
-
-
-
-
?
mt-pre-tRNAGly + H2O
mt-tRNAGly + 3'-leader of tRNA
show the reaction diagram
-
-
-
-
?
mt-pre-tRNALeu + H2O
mt-tRNALeu + 3'-leader of tRNA
show the reaction diagram
-
-
-
-
?
mt-pre-tRNALys + H2O
mt-tRNALys + 3'-leader of tRNA
show the reaction diagram
-
-
-
-
?
mt-pre-tRNAVal + H2O
mt-tRNAVal + 3'-leader of tRNA
show the reaction diagram
-
-
-
-
?
pre-tRNA(Arg) + H2O
?
show the reaction diagram
-
-
-
-
?
pre-tRNA(Val) + H2O
?
show the reaction diagram
-
-
-
-
?
pre-tRNAarg + H2O
?
show the reaction diagram
pre-tRNACys + H2O
?
show the reaction diagram
-
-
-
-
?
pre-tRNAGlu + H2O
?
show the reaction diagram
-
-
-
-
?
pre-tRNAGly + H2O
?
show the reaction diagram
-
-
-
-
?
pre-tRNAHis + H2O
?
show the reaction diagram
-
-
-
-
?
pre-tRNAIle + H2O
?
show the reaction diagram
-
-
-
-
?
pre-tRNALeu(CUN) + H2O
?
show the reaction diagram
-
-
-
-
?
pre-tRNALeu(UUR) + H2O
?
show the reaction diagram
-
-
-
-
?
pre-tRNALys + H2O
?
show the reaction diagram
-
-
-
-
?
pre-tRNASer(AGY) + H2O
?
show the reaction diagram
-
-
-
-
?
pre-tRNASer(UCN) + H2O
?
show the reaction diagram
-
wild type
-
-
?
pre-tRNASer(UCN)7443C + H2O
?
show the reaction diagram
-
natural tRNA mutant
-
-
?
pre-tRNASer(UCN)7444U + H2O
?
show the reaction diagram
-
natural tRNA mutant
-
-
?
pre-tRNASer(UCN)7445C + H2O
?
show the reaction diagram
-
natural tRNA mutant
-
-
?
pre-tRNASer(UCN)7445G + H2O
?
show the reaction diagram
-
natural tRNA mutant
-
-
?
pre-tRNASer(UCN)7510G + H2O
?
show the reaction diagram
-
natural tRNA mutant
-
-
?
pre-tRNASer(UCN)7511G + H2O
?
show the reaction diagram
-
natural tRNA mutant
-
-
?
pre-tRNASer(UCN)7512G + H2O
?
show the reaction diagram
-
natural tRNA mutant
-
-
?
pre-tRNAThr + H2O
?
show the reaction diagram
-
-
-
-
?
pre-tRNATyr + H2O
?
show the reaction diagram
-
-
-
-
?
precursor tRNASer(UGA)-M + H2O
mature tRNASer(UGA)-M
show the reaction diagram
-
overexpression of ELAC2 increases the abundance of mature tRNASer(UGA)-M in strain yYH1
-
-
?
usRNA1 + H2O
?
show the reaction diagram
-
24 nt unstructured RNA
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
degraded RNA such as a 5'-half-tRNA and an rRNA fragment function as small guide RNA (sgRNA) guide the enzyme to target RNA
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
metal requirements, overview
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000016
pre-tRNA(Arg)
-
-
-
0.0000043
pre-tRNA(Val)
-
-
-
0.000022 - 0.000132
pre-tRNAArg
-
0.000029
pre-tRNAGly
-
25 mM K-MOPS, 2 mM MgCl2, at pH 6.8 and 37°C
-
0.000018
pre-tRNAHis
-
25 mM K-MOPS, 2 mM MgCl2, at pH 6.8 and 37°C
-
0.000048
pre-tRNAIle
-
25 mM K-MOPS, 2 mM MgCl2, at pH 6.8 and 37°C
-
0.000024
pre-tRNALeu(UUR)
-
25 mM K-MOPS, 3 mM CaCl2, at pH 6.8 and 37°C
-
0.0000048
pre-tRNASer(UCN)
-
25 mM K-MOPS, pH 6.75, 2.5 mM CaCl2, 1 mM dithiothreitol, 5% glycerol, 4 U/ml RNasin, 100 microg/ml bovine serum albumin
-
0.0000633
pre-tRNASer(UCN)7443C
-
25 mM K-MOPS, pH 6.75, 2.5 mM CaCl2, 1 mM dithiothreitol, 5% glycerol, 4 U/ml RNasin, 100 microg/ml bovine serum albumin
-
0.0000069
pre-tRNASer(UCN)7444U
-
25 mM K-MOPS, pH 6.75, 2.5 mM CaCl2, 1 mM dithiothreitol, 5% glycerol, 4 U/ml RNasin, 100 microg/ml bovine serum albumin
-
0.0000197
pre-tRNASer(UCN)7445C
-
25 mM K-MOPS, pH 6.75, 2.5 mM CaCl2, 1 mM dithiothreitol, 5% glycerol, 4 U/ml RNasin, 100 microg/ml bovine serum albumin
-
0.0000855
pre-tRNASer(UCN)7445G
-
25 mM K-MOPS, pH 6.75, 2.5 mM CaCl2, 1 mM dithiothreitol, 5% glycerol, 4 U/ml RNasin, 100 microg/ml bovine serum albumin
-
0.0000108
pre-tRNASer(UCN)7510G
-
25 mM K-MOPS, pH 6.75, 2.5 mM CaCl2, 1 mM dithiothreitol, 5% glycerol, 4 U/ml RNasin, 100 microg/ml bovine serum albumin
-
0.0000076
pre-tRNASer(UCN)7511G
-
25 mM K-MOPS, pH 6.75, 2.5 mM CaCl2, 1 mM dithiothreitol, 5% glycerol, 4 U/ml RNasin, 100 microg/ml bovine serum albumin
-
0.000004
pre-tRNASer(UCN)7512G
-
25 mM K-MOPS, pH 6.75, 2.5 mM CaCl2, 1 mM dithiothreitol, 5% glycerol, 4 U/ml RNasin, 100 microg/ml bovine serum albumin
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.67
pre-tRNA(Arg)
-
-
-
0.27
pre-tRNA(Val)
-
-
-
0.021 - 6.18
pre-tRNAArg
-
0.035
pre-tRNAGly
-
25 mM K-MOPS, 2 mM MgCl2, at pH 6.8 and 37°C
-
0.237
pre-tRNAHis
-
25 mM K-MOPS, 2 mM MgCl2, at pH 6.8 and 37°C
-
0.018
pre-tRNAIle
-
25 mM K-MOPS, 2 mM MgCl2, at pH 6.8 and 37°C
-
0.25
pre-tRNALeu(UUR)
-
25 mM K-MOPS, 3 mM CaCl2, at pH 6.8 and 37°C
-
0.07
pre-tRNASer(UCN)
-
25 mM K-MOPS, pH 6.75, 2.5 mM CaCl2, 1 mM dithiothreitol, 5% glycerol, 4 U/ml RNasin, 100 microg/ml bovine serum albumin
-
0.23
pre-tRNASer(UCN)7443C
-
25 mM K-MOPS, pH 6.75, 2.5 mM CaCl2, 1 mM dithiothreitol, 5% glycerol, 4 U/ml RNasin, 100 microg/ml bovine serum albumin
-
0.153
pre-tRNASer(UCN)7444U
-
25 mM K-MOPS, pH 6.75, 2.5 mM CaCl2, 1 mM dithiothreitol, 5% glycerol, 4 U/ml RNasin, 100 microg/ml bovine serum albumin
-
0.012
pre-tRNASer(UCN)7445C
-
25 mM K-MOPS, pH 6.75, 2.5 mM CaCl2, 1 mM dithiothreitol, 5% glycerol, 4 U/ml RNasin, 100 microg/ml bovine serum albumin
-
0.345
pre-tRNASer(UCN)7445G
-
25 mM K-MOPS, pH 6.75, 2.5 mM CaCl2, 1 mM dithiothreitol, 5% glycerol, 4 U/ml RNasin, 100 microg/ml bovine serum albumin
-
0.05
pre-tRNASer(UCN)7510G, pre-tRNASer(UCN)7511G, pre-tRNASer(UCN)7512G
-
25 mM K-MOPS, pH 6.75, 2.5 mM CaCl2, 1 mM dithiothreitol, 5% glycerol, 4 U/ml RNasin, 100 microg/ml bovine serum albumin
-
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1233
pre-tRNAGly
-
25 mM K-MOPS, 2 mM MgCl2, at pH 6.8 and 37°C
-
12670
pre-tRNAHis
-
25 mM K-MOPS, 2 mM MgCl2, at pH 6.8 and 37°C
-
417
pre-tRNAIle
-
25 mM K-MOPS, 2 mM MgCl2, at pH 6.8 and 37°C
-
15500
pre-tRNALeu(UUR)
-
25 mM K-MOPS, 3 mM CaCl2, at pH 6.8 and 37°C
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
involvement in 3'-end processing of pre-mRNAs, roles in 3'-end processing of RNA precursors, DNA repair, V(D)J recombination, and telomere maintenance reviewed, linkage to human disease given, overview
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.6
-
long isoform, calculated from amino acid sequence
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
-
293 cell
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
additional information
-
recombinant ELAC2 is localized to the nucleus of Schizosaccharomyces pombe
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
RNZ1_HUMAN
363
0
40019
Swiss-Prot
other Location (Reliability: 2)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
40000
-
SDS-PAGE
84000
-
1 * 84000, long isoform, SDS-PAGE
86000
-
SDS-PAGE
86997
-
1 * 86997, long isoform, calculated from amino acid sequence
87004
-
1 * 87004, long isoform, MALDI-TOF mass spectrometry
94000
-
DELTA30 tRNase ZL, Western blotting
98000
-
full-length tRNase ZL, Western blotting
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
structural features of tRNase Z summarized, overview
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1641insG
-
frameshift mutation of ELAC2, lacks the C-terminal half, cannot increase suppression of ade6-704 in strain yYH1
A541T
D515A
-
tested for activity in presence of Mg2+ or Mn2+
D550A
-
Asp(I), active site residue
D666A
-
Asp(II), active site residue
E518A
-
tested for activity in presence of Mg2+ or Mn2+
E89A
-
influence on activity tested
F109S
-
influence on activity tested
G120Y
-
influence on activity tested
G281Y
-
influence on activity tested
G554L
-
tested for activity in presence of Mg2+ or Mn2+
H546A
H548A
-
His(II), active site residue
H551A
-
His(III), active site residue
H685A
-
tested for activity in presence of Mg2+ or Mn2+
H702A
-
His(V), active site residue
H724A
-
His(VI), active site residue
K282A
-
influence on activity tested
L539A
-
tested for activity in presence of Mg2+ or Mn2+
P493A
-
tested for activity in presence of Mg2+ or Mn2+
R497A
-
tested for activity in presence of Mg2+ or Mn2+
R718H
-
seems to be associated with the occurrence of prostate cancer
R781H
-
overexpression of this missense mutant of ELAC2 can increase suppression of ade6-704 in strain yYH1
S217L
T520Q
-
tested for activity in presence of Mg2+ or Mn2+
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
full-length and DELTA30 tRNase ZL recombinant proteins purified on nickel column or on chitin beads
-
His-tag, Ni-affinity chromatography
-
nickel-chelate resin column chromatography and Superose 6 gel filtration
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
293 and HeLa cells co-transfected with the tRNase ZL expression plasmid (+ZL), the tRNase ZS expression plasmid (+ZS), the tRNase ZL siRNA (-ZL), or the Ago2 siRNAs
-
expressed in a baculovirus-infection system
-
expressed in Sf-9 cells
-
expression in Escherichia coli
-
expression in Escherichia coli BL21(DE3)
-
expression of EGFP-tagged isozymes in HEK 293 cells. Alternative translation initiation is responsible for the dual targeting of RNase ZL. Due to the unfavorable context of the first AUG of ELAC2, translation apparently also starts from the second AUG, whereby the mitochondrial targeting sequence is lost and the protein is instead routed to the nucleus
-
histidine-tagged full-length and DELTA30 tRNase ZL proteins overexpressed from the expression plasmid pQE-80L in Escherichia coli strain Rosetta(DE3)pLysS. Full-length and DELTA30 tRNase ZL proteins also overexpressed from the expression plasmid pTYB11. 293 cells cotransfected with one of the pGL3 series plasmids and the expression plasmid pTK-b together with chemically synthesized 5'-half-tRNAGlu, the 28S rRNA fragment, the tRNase ZL or tRNase ZS expression plasmid, the tRNase ZL siRNA, or the four human Ago2 siRNAs
-
lacking the N-terminal 30 amino acids, His-tag
-
PCR products of ELAC1 digested with XhoI and BamHI, and cloned between the XhoI/BamHI sites of pREP4X, producing pREP4X-f-ELAC1. PCR products of ELAC2 digested with XhoI and XmaI, and cloned between the XhoI/XmaI sites of pREP4X, generating pREP4X-f-ELAC2, pREP4X-f-ELAC2-S217L, pREP4X-f-ELAC2-A541T, pREP4X-f-ELAC2-R781H and pREP4X-f-ELAC2-1641insG, respectively. Overexpressed in sla1+ (yYH1) or isogenetic sla1DELTA (yAS110) cells. FLAG-tagged wild-type or mutants overproduced in the heterozygous diploid Schizosaccharomyces pombe strain trz1+/trz1DELTA
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
siRNA targeting the tRNase ZL mRNA
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nashimoto, M.
Distribution of both lengths and 5' terminal nucleotides of mammalian pre-tRNA 3' trailers reflects properties of 3' processing endoribonuclease
Nucleic Acids Res.
25
1148-1154
1997
Homo sapiens, Mus musculus, Sus scrofa
Manually annotated by BRENDA team
Mrl, M.; Marchfelder, A.
The final cut. The importance of tRNA 3'-processing
EMBO Rep.
2
17-20
2001
Saccharomyces cerevisiae, Homo sapiens, Physarum sp., Rattus norvegicus
Manually annotated by BRENDA team
Shibata, H.S.; Minagawa, A.; Takaku, H.; Takagi, M.; Nashimoto, M.
Unstructured RNA is a substrate for tRNase Z
Biochemistry
45
5486-5492
2006
Bacillus subtilis, Escherichia coli, Homo sapiens, Pyrobaculum aerophilum, Saccharomyces cerevisiae, Sus scrofa, Thermotoga maritima
Manually annotated by BRENDA team
Vogel, A.; Schilling, O.; Spath, B.; Marchfelder, A.
The tRNase Z family of proteins: physiological functions, substrate specificity and structural properties
Biol. Chem.
386
1253-1264
2005
Arabidopsis thaliana, Arabidopsis thaliana (Q8L633), Arabidopsis thaliana (Q8LGU7), Arabidopsis thaliana (Q8VYS2), Bacillus subtilis (P54548), Caenorhabditis elegans (O44476), Drosophila melanogaster (Q8MKW7), Escherichia coli (P0A8V0), Haloferax volcanii, Homo sapiens (Q9BQ52), Homo sapiens (Q9H777), Methanocaldococcus jannaschii (Q58897), Pyrobaculum aerophilum (Q8ZTJ7), Pyrococcus furiosus (Q8U182), Saccharomyces cerevisiae (P36159), Thermoplasma acidophilum (Q9HJ19), Thermotoga maritima
Manually annotated by BRENDA team
Yan, H.; Zareen, N.; Levinger, L.
Naturally occurring mutations in human mitochondrial pre-tRNASer(UCN) can affect the transfer ribonuclease Z cleavage site, processing kinetics, and substrate secondary structure
J. Biol. Chem.
281
3926-3935
2006
Homo sapiens
Manually annotated by BRENDA team
Spaeth, B.; Canino, G.; Marchfelder, A.
tRNase Z: the end is not in sight
Cell. Mol. Life Sci.
64
2404-2412
2007
Arabidopsis thaliana, Caenorhabditis elegans, Danio rerio, Drosophila melanogaster (Q8MKW7), Gallus gallus, Homo sapiens, Mus musculus, Neurospora crassa, Saccharomyces cerevisiae, Schizosaccharomyces pombe
Manually annotated by BRENDA team
Dominski, Z.
Nucleases of the metallo-beta-lactamase family and their role in DNA and RNA metabolism
Crit. Rev. Biochem. Mol. Biol.
42
67-93
2007
Escherichia coli, Homo sapiens
Manually annotated by BRENDA team
Ceballos, M.; Vioque, A.
tRNase Z
Protein Pept. Lett.
14
137-145
2007
Synechocystis sp., Arabidopsis thaliana, Bacillus subtilis, Escherichia coli, Homo sapiens, Methanocaldococcus jannaschii, Thermotoga maritima
Manually annotated by BRENDA team
Elbarbary, R.A.; Takaku, H.; Nashimoto, M.
Functional analyses for tRNase Z variants: an aspartate and a histidine in the active site are essential for the catalytic activity
Biochim. Biophys. Acta
1784
2079-2085
2008
Bacillus subtilis, Escherichia coli, Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Takahashi, M.; Takaku, H.; Nashimoto, M.
Regulation of the human tRNase ZS gene expression
FEBS Lett.
582
2532-2536
2008
Homo sapiens
Manually annotated by BRENDA team
Hopkinson, A.; Levinger, L.
Effects of conserved D/T loop substitutions in the pre-tRNA substrate on tRNase Z catalysis
RNA Biol.
5
104-111
2008
Homo sapiens
Manually annotated by BRENDA team
Zhao, Z.; Su, W.; Yuan, S.; Huang, Y.
Functional conservation of tRNase ZL among Saccharomyces cerevisiae, Schizosaccharomyces pombe and humans
Biochem. J.
422
483-492
2009
Homo sapiens, Saccharomyces cerevisiae, Schizosaccharomyces pombe (P87168), Schizosaccharomyces pombe (Q10155), Schizosaccharomyces pombe
Manually annotated by BRENDA team
Elbarbary, R.A.; Takaku, H.; Uchiumi, N.; Tamiya, H.; Abe, M.; Nishida, H.; Nashimoto, M.
Human cytosolic tRNase ZL can downregulate gene expression through miRNA
FEBS Lett.
583
3241-3246
2009
Homo sapiens
Manually annotated by BRENDA team
Elbarbary, R.A.; Takaku, H.; Uchiumi, N.; Tamiya, H.; Abe, M.; Takahashi, M.; Nishida, H.; Nashimoto, M.
Modulation of gene expression by human cytosolic tRNase Z(L) through 5-half-tRNA
PLoS ONE
4
e5908
2009
Homo sapiens
Manually annotated by BRENDA team
Rossmanith, W.
Localization of human RNase Z isoforms: dual nuclear/mitochondrial targeting of the ELAC2 gene product by alternative translation initiation
PLoS ONE
6
e19152
2011
Homo sapiens
Manually annotated by BRENDA team
Brzezniak, L.; Bijata, M.; Szczesny, R.; Stepien, P.
Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs
RNA Biol.
8
616-626
2011
Homo sapiens
Manually annotated by BRENDA team
Wang, Z.; Zheng, J.; Zhang, X.; Peng, J.; Liu, J.; Huang, Y.
Identification and sequence analysis of metazoan tRNA 3-end processing enzymes tRNase ZS
PLoS ONE
7
e44264
2012
Amphimedon queenslandica, Bombyx mori, Branchiostoma floridae, Caenorhabditis elegans, Canis lupus familiaris, Capitella teleta, Ciona intestinalis, Danio rerio, Drosophila melanogaster, Homo sapiens, Hydra vulgaris, Lottia gigantea, Loxodonta africana, Monosiga brevicollis, Mus musculus, Nematostella vectensis, Salmo salar, Strongylocentrotus purpuratus, Tribolium castaneum, Trichoplax adhaerens, Xenopus tropicalis
Manually annotated by BRENDA team
Wilson, C.; Ramai, D.; Serjanov, D.; Lama, N.; Levinger, L.; Chang, E.J.
Tethered domains and flexible regions in tRNase Z(L), the long form of tRNase Z
PLoS ONE
8
e66942
2013
Drosophila melanogaster, Homo sapiens
Manually annotated by BRENDA team
Levinger, L.; Serjanov, D.
Pathogenesis-related mutations in the T-loops of human mitochondrial tRNAs affect 3' end processing and tRNA structure
RNA Biol.
9
283-291
2012
Homo sapiens
Manually annotated by BRENDA team
Ninomiya, S.; Kawano, M.; Abe, T.; Ishikawa, T.; Takahashi, M.; Tamura, M.; Takahashi, Y.; Nashimoto, M.
Potential small guide RNAs for tRNase ZL from human plasma, peripheral blood mononuclear cells, and cultured cell lines
PLoS ONE
10
e0118631
2015
Homo sapiens
Manually annotated by BRENDA team