Disease on EC 3.1.22.1 - deoxyribonuclease II

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DISEASE
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Arthritis
Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages.
Cutting Edge: DNase II Deficiency Prevents Activation of Autoreactive B Cells by Double-Stranded DNA Endogenous Ligands.
IFN regulatory factor (IRF) 3/7-dependent and -independent gene induction by mammalian DNA that escapes degradation.
Protective targeting of high mobility group box chromosomal protein 1 in a spontaneous arthritis model.
Arthritis, Rheumatoid
Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages.
Genetic and expression analysis of SNPs in the human deoxyribonuclease II: SNPs in the promoter region reduce its in vivo activity through decreased promoter activity.
Protective targeting of high mobility group box chromosomal protein 1 in a spontaneous arthritis model.
Seven nonsynonymous SNPs in the gene encoding human deoxyribonuclease II may serve as a functional SNP potentially implicated in autoimmune dysfunction.
Ascorbic Acid Deficiency
[Development of acid deoxyribonuclease or DNase II activity during ascorbic acid deficiency in the guinea pig]
Autoimmune Diseases
Molecular basis of DNA recognition in the immune system.
Avitaminosis
[Characteristics of the deoxyribonuclease II activity of the guinea pig liver during acute avitaminosis C]
[Comparison of effects of avitaminosis C on activity of acid DNase of testis in the young and adult guinea pig]
[Testicular degeneration and DNase II activity in various avitaminoses]
Bacterial Infections
Activation of the innate immunity in Drosophila by endogenous chromosomal DNA that escaped apoptotic degradation.
Carcinogenesis
Induction of the deficient acid DNAse activity in mouse interfollicular epidermis by croton oil as a possible tumor promoting mechanism.
[Interaction between lysosomes and cell nucleus during diethylnitrosamine-induced carcinogenesis. I. Changes in subcellular distribution of the lysosomal enzymes acid deoxyribonuclease and beta-galactosidase during acute intoxication by diethylnitrosamine]
Carcinoma, Ehrlich Tumor
Association of DNA with the nuclear lamina in Ehrlich ascites tumor cells.
Carcinoma, Hepatocellular
Periodicity and fragment size of DNA from mouse TLT hepatoma chromatin and chromatin fractions using endogenous and exogenous nucleases.
Cardiomegaly
Novel Role for Caspase-Activated DNase in the Regulation of Pathological Cardiac Hypertrophy.
Cataract
Involvement of DNase II-like acid DNase in the cataract formation of the UPL rat and the Shumiya cataract rat.
Choriocarcinoma
Expression of constitutively active c-MET receptor in human choriocarcinoma.
Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo.
Macrophage colony-stimulating factor induces the growth and differentiation of normal pregnancy human cytotrophoblast cells and hydatidiform moles but does not induce the growth and differentiation of choriocarcinoma cells.
[Studies on HLA-class I and class II antigen expression in cultured choriocarcinoma cell lines]
Choriocarcinoma, Non-gestational
[Studies on HLA-class I and class II antigen expression in cultured choriocarcinoma cell lines]
Cryptorchidism
[Influence of experimental cryptorchism on the ascorbic acid content and acid deoxyribonuclease activity of rat testis]
Cystic Fibrosis
Structural requirements of human DNase II alpha for formation of the active enzyme: the role of the signal peptide, N-glycosylation, and disulphide bridging.
Cysts
[Deoxyribonuclease II activity in Sarcocystis fusiformis and S. gigantea cysts]
deoxyribonuclease ii deficiency
Cutting Edge: DNase II Deficiency Prevents Activation of Autoreactive B Cells by Double-Stranded DNA Endogenous Ligands.
DNase II deficiency impairs innate immune function in Drosophila.
Reversibility of acid and alkaline deoxyribonuclease deficiency in malignant tumor cells.
Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice.
Endometrial Neoplasms
Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo.
Esophagitis, Peptic
The Activities of Acid DNase and 5'Nucleotidase in Erosive Reflux Esophagitis and Barrett's Epithelium.
Fibroma
Fibroma virus-induced acid deoxyribonuclease in rabbit kidney cells.
Fowlpox
Cloning and expression of deoxyribonuclease II from chicken.
Infection
DNase II deficiency impairs innate immune function in Drosophila.
Fowlpox virus encodes nonessential homologs of cellular alpha-SNAP, PC-1, and an orphan human homolog of a secreted nematode protein.
Leukemia
Intragenomic distribution of 5-methylcytosine in various forms of human and murine leukemic cells.
[Cytochemical identification of acid deoxyribonuclease in blood cell cytoplasm. 3. Activity of acid deoxyribonuclease in leukocyte cytoplasm of children suffering from acute leukemia]
Leukemia, Erythroblastic, Acute
Localization of DNA methyltransferase in the chromatin of Friend erythroleukemia cells.
Lupus Erythematosus, Systemic
DNase II polymorphisms associated with risk of renal disorder among systemic lupus erythematosus patients.
[DNAse II from phagocytes in the study of the pathogenesis of systemic lupus erythematosus]
Lymphoma, Non-Hodgkin
Selective effect of cortisol on deoxyribonuclease II activity of lymphosarcoma P1798.
Malnutrition
Differential effects of early undernutrition in white and grey matter regions of rat brain.
Muscular Dystrophies
ENZYME STUDIES IN MUSCULAR DYSTROPHY. IV. ACID DEOXYRIBONUCLEASE IN NUTRITIONAL AND HEREDITARY MUSCULAR DYSTROPHY.
ENZYME STUDIES IN MUSCULAR DYSTROPHY. VI. CATHEPSIN AND ACID DEOXYRIBONUCLEASE ACTIVITIES DURING THE PROGRESSION OF HEREDITARY MUSCULAR DYSTROPHY IN THE CHICKEN.
Neoplasms
Altered deoxyribonuclease activity in cancer cells and its role in non toxic adjuvant cancer therapy with mixed vitamins C and K3.
Association of DNA with the nuclear lamina in Ehrlich ascites tumor cells.
Bond-cleaving specificity of a deoxyribonuclease II from mouse mammary tumors.
Changes in the template activity of chromatin isolated from sarcoma-180 ascites cells treated with mitomycin C and gamma irradiation in vivo.
DNase II and the Chk2 DNA Damage Pathway Form a Genetic Barrier Blocking Replication of Horizontally Transferred DNA.
Effect of deoxyribonuclease on adriamycin-polynucleotide complexes.
Histochemical investigations on acid deoxyribonuclease in some tumours.
Hyperplasia of epithelium adjacent to transitional cell carcinoma can be induced by growth factors through paracrine pathways.
Induction of the deficient acid DNAse activity in mouse interfollicular epidermis by croton oil as a possible tumor promoting mechanism.
Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo.
Nucleases and adenosine 3',5'-cyclic monophosphate phosphodiesterase activities in murine sarcoma virus (Moloney)-infected mice.
Reversibility of acid and alkaline deoxyribonuclease deficiency in malignant tumor cells.
The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy.
The inhibition of tumor growth and deoxyribonuclease II by anionic polyelectrolytes.
[Cytochemical determination of acid deoxyribonuclease activity in the nuclei of lymphocytes of BALB/c mice with methylcholanthrene-induced tumors]
[Deoxyribonucleases in spontaneous and experimental tumors of the nervous system]
[Histone specific proteinase and DNase activity of spleen lymphocyte nuclei during oncogenesis and under the effect of hydrobromide-5-(5',6' benzocoumaroyl-3')-methylaminouracil]
Neuroblastoma
Embryonic chicken brain and mouse neuroblastoma cells N1E-115 and N-18 contain an inhibitor of acid deoxyribonuclease.
Ovarian Neoplasms
Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo.
Pancreatic Diseases
Clinical investigation of serum deoxyribonuclease: II. Clinical studies of serum deoxyribonuclease activity in pancreatic disease.
Pancreatitis
Relationship between pancreatic enzymes and pathological changes in the pancreas in acute pancreatitis. The significance of determination of serum deoxyribonuclease.
Psoriasis
[Change in the activity of acid proteinase and deoxyribonuclease II of blood serum in psoriasis]
Retinal Degeneration
The activation of the atypical PKC zeta in light-induced retinal degeneration and its involvement in L-DNase II control.
The LEI/L-DNase II pathway is activated in light-induced retinal degeneration in rats.
Sarcoma
Immunological studies on Yoshida sarcoma cells. I. The effect of heterologous anti-Yoshida sarcoma cell antibodies on the lysosomal acid DNase of sarcoma cells.
Nucleases and adenosine 3',5'-cyclic monophosphate phosphodiesterase activities in murine sarcoma virus (Moloney)-infected mice.
Susceptibility of Rous sarcoma virus-specific sequences integrated into SR-C3H/He mouse ascites sarcoma cell chromatin to DNase I and DNase II.
Sarcoma, Avian
Susceptibility of Rous sarcoma virus-specific sequences integrated into SR-C3H/He mouse ascites sarcoma cell chromatin to DNase I and DNase II.
Sarcoma, Yoshida
Immunological studies on Yoshida sarcoma cells. I. The effect of heterologous anti-Yoshida sarcoma cell antibodies on the lysosomal acid DNase of sarcoma cells.
Seizures
Nuclear translocation of mitochondrial cytochrome c, lysosomal cathepsins B and D, and three other death-promoting proteins within the first 60 minutes of generalized seizures.
Picrotoxin-induced convulsions and lysosomal function in the rat brain.
Starvation
Genetic regulation of phosphate transport system II in Neurospora.
Trichinellosis
Screening and characterization of early diagnostic antigens in excretory-secretory proteins from Trichinella spiralis intestinal infective larvae by immunoproteomics.
Vaccinia
5'OH DNA breaks in apoptosis and their labeling by topoisomerase-based approach.
Virus Diseases
Cytochemical studies of polyoma virus infection. 3. Deoxyribonuclease II.
Nucleases and adenosine 3',5'-cyclic monophosphate phosphodiesterase activities in murine sarcoma virus (Moloney)-infected mice.
Vitamin A Deficiency
[Acid deoxyribonuclease activity and testicular degeneration in rats with vitamin A deficiency]