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Information on EC 3.1.22.1 - deoxyribonuclease II and Organism(s) Rattus norvegicus and UniProt Accession Q9QZK8

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This record set is specific for:
Rattus norvegicus
UNIPROT: Q9QZK8 not found.
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Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
Synonyms
dnase ii, nuc-1, acid dnase, deoxyribonuclease ii, l-dnase ii, acid deoxyribonuclease, lei/l-dnase ii, dnase iialpha, dnase iibeta, dnase 2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
DNase IIalpha
-
acid deoxyribonuclease
-
-
-
-
acid DNase
deoxyribonucleate 3'-nucleotidohydrolase
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-
-
-
DNase II
-
-
-
-
LEI-derived DNase II
-
-
leukocyte elastase inhibitor-derived DNase II
-
-
lysosomal DNase II
-
-
-
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pancreatic DNase II
-
-
-
-
R31240_2
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
9025-64-3
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
DNA + H2O
3'-phosphooligonucleotides + 5'-hydroxyoligonucleotides
show the reaction diagram
-
The LEI/L-DNase II pathway is activated in light-induced retinal degeneration
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
DNA + H2O
3'-phosphooligonucleotides + 5'-hydroxyoligonucleotides
show the reaction diagram
-
The LEI/L-DNase II pathway is activated in light-induced retinal degeneration
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
somato-lactotrope cell
Manually annotated by BRENDA team
additional information
-
F-258 cell
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DNS2A_RAT
350
0
38175
Swiss-Prot
Secretory Pathway (Reliability: 1)
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
proteolytic modification
-
epidermal growth factor triggers a cleavage of Leukocyte Elastase Inhibitor precursor into L-DNase II, its subsequent enzymatic activation and nuclear translocation
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
MacLea, K.S.; Krieser, R.J.; Eastman, A.
A family history of deoxyribonuclease II: surprises from Trichinella spiralis and Burkholderia pseudomallei
Gene
305
1-12
2003
Bos taurus (P56541), Caenorhabditis elegans (P34387), Caenorhabditis elegans (P34508), Caenorhabditis elegans (Q17778), Caenorhabditis elegans, Caenorhabditis elegans F09G8.2 (P34387), Caenorhabditis elegans K04H4.6 (P34508), Caenorhabditis elegans NUC-1 (Q17778), Drosophila melanogaster (Q7JYM9), Homo sapiens (O00115), Homo sapiens (Q8WZ79), Homo sapiens, Mus musculus (P56542), Mus musculus (Q9QY48), Rattus norvegicus (Q9QZK8), Rattus norvegicus (Q9QZK9), Sus scrofa (O62855)
Manually annotated by BRENDA team
Chahory, S.; Padron, L.; Courtois, Y.; Torriglia, A.
The LEI/L-DNase II pathway is activated in light-induced retinal degeneration in rats
Neurosci. Lett.
367
205-209
2004
Rattus norvegicus, Rattus norvegicus Fischer
Manually annotated by BRENDA team
Fombonne, J.; Padron, L.; Enjalbert, A.; Krantic, S.; Torriglia, A.
A novel paraptosis pathway involving LEI/L-DNaseII for EGF-induced cell death in somato-lactotrope pituitary cells
Apoptosis
11
367-375
2006
Rattus norvegicus
Manually annotated by BRENDA team
Valamanesh, F.; Torriglia, A.; Savoldelli, M.; Gandolphe, C.; Jeanny, J.C.; BenEzra, D.; Behar-Cohen, F.
Glucocorticoids induce retinal toxicity through mechanisms mainly associated with paraptosis
Mol. Vis.
13
1746-1757
2007
Rattus norvegicus
Manually annotated by BRENDA team
Torriglia, A.; Lepretre, C.; Padron-Barthe, L.; Chahory, S.; Martin, E.
Molecular mechanism of L-DNase II activation and function as a molecular switch in apoptosis
Biochem. Pharmacol.
76
1490-1502
2008
Gallus gallus, Cricetulus griseus, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team