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(S)-D-lactoylglutathione + H2O
D-lactate + glutathione
(S)-D-mandeloylglutathione + H2O
D-mandelate + glutathione
-
-
-
-
?
bis(pivaloyloxymethyl)(1-hydroxy-2-oxopiperidin-3-yl)phosphonate + H2O
[[(hydroxymethoxy)(1-hydroxy-2-oxopiperidin-3-yl)phosphoryl]oxy]methyl 2,2-dimethylpropanoate + 2,2-dimethylpropanoate
i.e. POM-HEX, substrate is a prodrug of the compound HEX, which inhibits the glycolytic enzyme enolase
-
-
?
bis-(lactoyl)trypanothione + H2O
D-lactate + trypanothione
-
-
-
?
bis-(lactoyl)trypanothione + H2O
trypanothione + D-lactate
preferred substrate
trypathione is bis(glutathionyl)spermidine
?
D-lactoyltrypanothione + H2O
D-lactate + trypanothione
-
-
-
?
fluorescein-3',6'-bis(oxy)methylene bis(2-methoxypropanoate) + H2O
fluorescein-3'-oxymethyl 2-methoxypropanoate + 2-methoxypropanoate
-
-
-
?
fluorescein-3',6'-bis(oxy)methylene bis(ethoxyacetate) + H2O
fluorescein-3'-yoxymethyl ethoxyacetate + ethoxyacetate
-
-
-
?
fluorescein-3',6'-bis(oxy)methylene bis(methoxyacetate) + H2O
fluorescein-3'-oxymethyl methoxyacetate + methoxyacetate
-
-
-
?
fluorescein-3',6'-bis(oxy)methylene bis(propoxyacetate) + H2O
fluorescein-3'-oxymethyl propoxyacetate + propoxyacetate
-
-
-
?
fluorescein-3',6'-bis(oxy)methylene bis[(ethylsulfanyl)acetate] + H2O
fluorescein-3'-oxymethyl (ethylsulfanyl)acetate + (ethylsulfanyl)acetate
-
-
-
?
fluorescein-3',6'-bis(oxy)methylene bis[(methylsulfanyl)acetate] + H2O
fluorescein-3'-oxymethyl (methylsulfanyl)acetate + (methylsulfanyl)acetate
-
-
-
?
fluorescein-3',6'-bis(oxy)methylene dibutanoate + H2O
fluorescein-3'-oxymethyl butanoate + butanoate
-
-
-
?
fluorescein-3',6'-bis(oxy)methylene dihexanoate + H2O
fluorescein-3'-oxymethyl hexanoate + hexanoate
-
-
-
?
fluorescein-3',6'-bis(oxy)methylene dipentanoate + H2O
fluorescein-3'-oxymethyl pentanoate + pentanoate
-
-
-
?
lactoylglutathione + H2O
D-lactate + glutathione
mono-(lactoyl)trypanothione + H2O
D-lactate + trypanothione
mono-(lactoyl)trypanothione + H2O
trypanothione + D-lactate
preferred substrate
trypathione is bis(glutathionyl)spermidine
?
N,S-bisfluorenylmethoxycarbonylglutathione + H2O
9-fluorenylmethoxycarboxylate + glutathione
-
-
-
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate anion
S-(beta-ethoxy-alpha-D-hydroxybutyryl)glutathione + H2O
beta-ethoxy-alpha-D-hydroxybutyrate + glutathione
-
-
-
-
?
S-(N-hydroxy-N-bromophenylcarbamoyl)glutathione + H2O
?
slow model substrate for computational study, the substrate does not coordinate to any of the zinc ions in the Michaelis complex. The hydroxyl group forms a hydrogen bond to the Asp58 residue.
-
-
?
S-(N-hydroxy-N-bromophenylcarbamoyl)glutathione + H2O
N-hydroxy-N-bromophenylcarbamate + glutathione
-
weak substrate
-
-
?
S-acetoacetylglutathione + H2O
acetoacetate + glutathione
S-acetylglutathione + H2O
acetate + glutathione
S-acetyltrypanothione + H2O
acetate + trypanothione
-
-
-
?
S-bis-lactoyltrypanothione + 2 H2O
2 D-lactate + trypanothione
-
-
-
?
S-D-lactoylglutathione
D-lactate + glutathione
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
S-D-lactoylglutathione + H2O
D-lactic acid + glutathione
-
-
-
?
S-D-lactoylglutathione + H2O
glutathione + D-lactate
S-D-lactoylglutathione + H2O
glutathione + D-lactic acid
-
-
-
r
S-D-lactoyltrypanothione + H2O
D-lactate + trypanothione
additionally S-D-lactoylglutathione used by mutant Y291R/C294K
-
-
?
S-D-mandeloylglutathione + H2O
? + glutathione
-
-
-
?
S-D-mandeloylglutathione + H2O
D-mandelate + glutathione
S-formylglutathione + H2O
formate + glutathione
S-glyceroylglutathione + H2O
glycerate + glutathione
-
-
-
-
?
S-glycerylglutathione + H2O
glycerate + glutathione
S-glycoloylglutathione + H2O
glycolate + glutathione
S-glycolylglutathione + H2O
? + glutathione
hydrolysis at about half the rate of S-lactoylglutathione
-
-
?
S-glycolyltrypanothione + H2O
glycolate + trypanothione
-
-
-
?
S-hydroxyglutaryltrypanothione + H2O
hydroxyglutarate + trypanothione + 2 H+
-
-
-
?
S-L-glyceroylglutathione + H2O
glycerate + glutathione
-
-
-
-
?
S-lactonylglutathione + H2O
? + glutathione
hydrolysis about 10fold lower than of S-lactoylglutathione
-
-
?
S-lactoylglutathione + H2O
D-lactate + glutathione
S-lactoylglutathione + H2O
GSH + D-lactate
-
-
-
-
?
S-lactoylglutathionylspermidine + H2O
?
-
-
-
?
S-m-nitrobenzyloxycarbonylglutathione + H2O
m-nitrobenzyloxycarboxylate + glutathione
-
-
-
-
?
S-mandeloylglutathione + H2O
mandelate + glutathione
S-mandeloylglutathione + H2O
mandelic acid + glutathione
hydrolysis about 10fold lower than of S-lactoylglutathione
-
-
?
S-methyl hydroxy(phenyl)ethanethioate + H2O
methanethiol + hydroxy(phenyl)acetic acid
S-o-nitrobenzyloxycarbonylglutathione + H2O
o-nitrobenzyloxycarboxylate + glutathione
-
-
-
-
?
S-p-nitrobenzyloxycarbonylglutathione + H2O
p-nitrobenzyloxycarboxylate + glutathione
-
-
-
-
?
S-propionylglutathione + H2O
propionate + glutathione
S-propionyltrypanothione + H2O
propionate + trypanothione + H+
-
-
-
?
S-succinylglutathione + H2O
succinate + glutathione
trypanothione hemithioacetal + H2O
?
-
-
-
-
ir
additional information
?
-
(S)-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
(S)-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
(S)-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
(S)-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
?
lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
lactoylglutathione + H2O
D-lactate + glutathione
-
S-D-lactoylglutathione
-
-
?
lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
?
lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
?
lactoylglutathione + H2O
D-lactate + glutathione
-
S-D-lactoylglutathione
-
?
lactoylglutathione + H2O
D-lactate + glutathione
little activity with this substrate
-
-
?
lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
lactoylglutathione + H2O
D-lactate + glutathione
-
S-D-lactoylglutathione
-
-
?
lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
lactoylglutathione + H2O
D-lactate + glutathione
-
reaction is rate-limiting, methylglyoxal bypass of glycolysis
-
-
r
lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
lactoylglutathione + H2O
D-lactate + glutathione
enzyme does not show saturation kinetics up to 5 mM
-
-
?
lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
mono-(lactoyl)trypanothione + H2O
D-lactate + trypanothione
-
-
-
?
mono-(lactoyl)trypanothione + H2O
D-lactate + trypanothione
-
-
-
-
ir
mono-(lactoyl)trypanothione + H2O
D-lactate + trypanothione
-
-
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate
-
-
-
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate
-
-
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate
-
-
-
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate
-
-
-
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate
-
-
-
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate
-
-
-
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate anion
-
-
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate anion
-
enzyme is part of the glyoxalase system and involved in detoxification of methylglyoxal
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate anion
-
-
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate anion
-
enzyme is part of the glyoxalase system and involved in detoxification of methylglyoxal
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate anion
-
second step in the glyoxalase system
regeneration of glutathione for the first step in the glyoxalase system
-
ir
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate anion
-
-
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate anion
-
the enzyme is involved in the detoxification process converting reactive dicarbonyl compounds such as methylglyoxal to less reactive hydroxyl acids
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate anion
-
-
?
S-acetoacetylglutathione + H2O
acetoacetate + glutathione
hydrolysis at about half the rate of S-lactoylglutathione
-
-
?
S-acetoacetylglutathione + H2O
acetoacetate + glutathione
-
-
-
-
?
S-acetoacetylglutathione + H2O
acetoacetate + glutathione
-
-
-
-
?
S-acetoacetylglutathione + H2O
acetoacetate + glutathione
-
-
-
-
?
S-acetoacetylglutathione + H2O
acetoacetate + glutathione
-
55.6% of the activity with S-lactoylglutathione
-
-
?
S-acetoacetylglutathione + H2O
acetoacetate + glutathione
-
-
-
-
?
S-acetoacetylglutathione + H2O
acetoacetate + glutathione
-
-
-
-
?
S-acetoacetylglutathione + H2O
acetoacetate + glutathione
-
-
-
-
?
S-acetylglutathione + H2O
acetate + glutathione
-
-
-
-
?
S-acetylglutathione + H2O
acetate + glutathione
hydrolysis about 10fold lower than of S-lactoylglutathione
-
-
?
S-acetylglutathione + H2O
acetate + glutathione
-
-
-
-
?
S-acetylglutathione + H2O
acetate + glutathione
-
-
-
-
?
S-acetylglutathione + H2O
acetate + glutathione
-
-
-
-
?
S-acetylglutathione + H2O
acetate + glutathione
-
-
-
?
S-acetylglutathione + H2O
acetate + glutathione
-
8.6% of the activity with S-lactoylglutathione
-
-
?
S-acetylglutathione + H2O
acetate + glutathione
-
-
-
-
?
S-acetylglutathione + H2O
acetate + glutathione
-
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
second step in the glyoxalase system
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
second step in the glyoxalase system, detoxification of methylglyoxal
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
second step in the glyoxalase system
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
second step in the glyoxalase system, detoxification of methylglyoxal
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
second step in the glyoxalase system
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
used by mutant Y291R/C294K
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
substrate is predominantly bound via ionic interactions with the conserved residues Arg257 and Lys260. Correct substrate binding is a pH- and salt-dependent rate-limiting step for catalysis. Bi Bi mechanism with the direct involvement of a hydroxide ion as a second substrate
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
second step in the glyoxalase system
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
second step in the glyoxalase system
-
-
?
S-D-lactoylglutathione + H2O
glutathione + D-lactate
-
-
-
?
S-D-lactoylglutathione + H2O
glutathione + D-lactate
-
-
?
S-D-lactoylglutathione + H2O
glutathione + D-lactate
-
-
?
S-D-lactoylglutathione + H2O
glutathione + D-lactate
-
-
?
S-D-lactoylglutathione + H2O
glutathione + D-lactate
-
-
-
-
?
S-D-lactoylglutathione + H2O
glutathione + D-lactate
-
-
-
?
S-D-lactoylglutathione + H2O
glutathione + D-lactate
-
-
-
?
S-D-lactoylglutathione + H2O
glutathione + D-lactate
-
-
?
S-D-lactoylglutathione + H2O
glutathione + D-lactate
-
-
-
?
S-D-lactoylglutathione + H2O
glutathione + D-lactate
-
enzyme is involved in the detoxification of methylglyoxal
-
?
S-D-lactoylglutathione + H2O
glutathione + D-lactate
-
-
-
?
S-D-lactoylglutathione + H2O
glutathione + D-lactate
-
enzyme is involved in the detoxification of methylglyoxal
-
?
S-D-lactoylglutathione + H2O
glutathione + D-lactate
-
-
?
S-D-lactoylglutathione + H2O
glutathione + D-lactate
enzyme is involved in the detoxification of ketoaldehydes such as methylglyoxal, which is mainly a byproduct of glycolysis
-
?
S-D-mandeloylglutathione + H2O
D-mandelate + glutathione
-
-
-
-
?
S-D-mandeloylglutathione + H2O
D-mandelate + glutathione
-
-
-
-
?
S-D-mandeloylglutathione + H2O
D-mandelate + glutathione
-
-
-
?
S-D-mandeloylglutathione + H2O
D-mandelate + glutathione
-
-
-
-
?
S-D-mandeloylglutathione + H2O
D-mandelate + glutathione
-
-
-
?
S-formylglutathione + H2O
formate + glutathione
-
-
-
-
?
S-formylglutathione + H2O
formate + glutathione
-
37.7% of the activity with S-lactoylglutathione
-
-
?
S-formylglutathione + H2O
formate + glutathione
-
-
-
-
?
S-glycerylglutathione + H2O
glycerate + glutathione
-
-
-
-
?
S-glycerylglutathione + H2O
glycerate + glutathione
-
61.6% of the activity with S-lactoylglutathione
-
-
?
S-glycoloylglutathione + H2O
glycolate + glutathione
-
-
-
-
?
S-glycoloylglutathione + H2O
glycolate + glutathione
-
38.6% of the activity with S-lactoylglutathione
-
-
?
S-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
S-lactoylglutathione + H2O
D-lactate + glutathione
preferred substrae
-
-
?
S-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
?
S-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
S-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
?
S-mandeloylglutathione + H2O
mandelate + glutathione
-
-
-
-
?
S-mandeloylglutathione + H2O
mandelate + glutathione
-
-
-
-
?
S-mandeloylglutathione + H2O
mandelate + glutathione
-
-
-
?
S-mandeloylglutathione + H2O
mandelate + glutathione
-
4.8% of the activity with S-lactoylglutathione
-
-
?
S-mandeloylglutathione + H2O
mandelate + glutathione
-
-
-
-
?
S-mandeloylglutathione + H2O
mandelate + glutathione
-
-
-
-
?
S-methyl hydroxy(phenyl)ethanethioate + H2O
methanethiol + hydroxy(phenyl)acetic acid
-
thioester hydrolysis is promoted by an Fe(III)Zn(II) complex
-
-
?
S-methyl hydroxy(phenyl)ethanethioate + H2O
methanethiol + hydroxy(phenyl)acetic acid
-
thioester hydrolysis promoted by a mononuclear zinc complex
-
-
?
S-propionylglutathione + H2O
propionate + glutathione
-
-
-
-
?
S-propionylglutathione + H2O
propionate + glutathione
-
13.5% of the activity with S-lactoylglutathione
-
-
?
S-propionylglutathione + H2O
propionate + glutathione
-
-
-
-
?
S-succinylglutathione + H2O
succinate + glutathione
-
-
-
-
?
S-succinylglutathione + H2O
succinate + glutathione
-
-
-
-
?
S-succinylglutathione + H2O
succinate + glutathione
-
-
-
-
?
S-succinylglutathione + H2O
succinate + glutathione
-
29.2% of the activity with S-lactoylglutathione
-
-
?
S-succinylglutathione + H2O
succinate + glutathione
-
-
-
-
?
S-succinylglutathione + H2O
succinate + glutathione
-
-
-
-
?
S-succinylglutathione + H2O
succinate + glutathione
-
-
-
-
?
additional information
?
-
the enzyme participates in the detoxification of cytotoxic and mutagenic 2-oxoaldehydes
-
?
additional information
?
-
no substrate: S-formylglutathione
-
-
?
additional information
?
-
-
no substrate: S-formylglutathione
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
the enzyme catalyzes the rate limiting step of the glyoxalase pathway
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
enzyme shows broad substrate specificity with a preference for 2-hydoxy thiol esters
-
?
additional information
?
-
enzyme shows broad substrate specificity with a preference for 2-hydoxy thiol esters
-
?
additional information
?
-
the GLX2 gene, which encodes glyoxalase II enzyme, is up-regulated by p63 and p73. Accordingly, a specific responsive element is found in intron 1 of the GLX2 gene, which can be activated and bound by p63 and p73. Upon overexpression, the cytosolic, but not the mitochondrial, GLX2 inhibits the apoptotic response of a cell to methylglyoxal, a by-product of glycolysis. Cells deficient in GLX2 are hypersensitive to methylglyoxal-induced apoptosis. A deficiency in GLX2 enhances the susceptibility of a cell to DNA damage-induced apoptosis in a p53-dependent manner
-
-
?
additional information
?
-
-
the GLX2 gene, which encodes glyoxalase II enzyme, is up-regulated by p63 and p73. Accordingly, a specific responsive element is found in intron 1 of the GLX2 gene, which can be activated and bound by p63 and p73. Upon overexpression, the cytosolic, but not the mitochondrial, GLX2 inhibits the apoptotic response of a cell to methylglyoxal, a by-product of glycolysis. Cells deficient in GLX2 are hypersensitive to methylglyoxal-induced apoptosis. A deficiency in GLX2 enhances the susceptibility of a cell to DNA damage-induced apoptosis in a p53-dependent manner
-
-
?
additional information
?
-
GlxII belongs to the metallo-beta-lactamase superfamily of proteins, in which a zinc-binding motif is conserved
-
-
?
additional information
?
-
the glyoxalase system can detoxify methylglyoxal, a by-product of carbohydrate and lipid metabolism, which can produce toxic effects by reacting with RNA, DNA and proteins
-
-
?
additional information
?
-
The glyoxalase system catalyzes the conversion of toxic methylglyoxal to nontoxic D-lactic acid using glutathione as a coenzyme. Glyoxalase II is a binuclear Zn-enzyme that catalyzes the second step of this conversion, namely the hydrolysis of S-D-lactoylglutathione, which is the product of the glyoxalase I (EC 4.4.15) reaction.
-
-
?
additional information
?
-
-
the enzyme does not promote S-glutathionylation of GAPDH
-
-
?
additional information
?
-
-
no substrate: S-lactoylglutathione
-
-
?
additional information
?
-
-
the glyoxalase system may play an important role in the regulation of cell division and differentiation
-
-
?
additional information
?
-
-
catalytic process involves a water molecule activated by a binuclear metal center containing one zinc atom plus a second bivalent metal ion which could be a zinc or an iron
-
-
?
additional information
?
-
-
glyoxalase system containing glyoxalase I and II catalyzes the conversion of 2-oxoaldehydes into their corresponding 2-hydroxyacids
-
-
?
additional information
?
-
OsglyII gene expression is stimulated within 15 min in response to various abiotic stresses as well as treatment with abscisic acid or salicylic acid
-
-
?
additional information
?
-
-
OsglyII gene expression is stimulated within 15 min in response to various abiotic stresses as well as treatment with abscisic acid or salicylic acid
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
no substrates: 4-nitrophenyl acetate, 4-nitrophenyl butanoate, 4-nitrophenyl trimethylacetate
-
-
-
additional information
?
-
recombinant glyoxalase II hydrolyzes the trypanothione-thioesters of methylglyoxal, glyoxal and 4,5-dioxovalerate, substrates of the classical glyoxalase system, with high efficiency
-
-
?
additional information
?
-
-
recombinant glyoxalase II hydrolyzes the trypanothione-thioesters of methylglyoxal, glyoxal and 4,5-dioxovalerate, substrates of the classical glyoxalase system, with high efficiency
-
-
?
additional information
?
-
The glyoxalase system, composed of glyoxalase I and II catalyzes the detoxification of reactive ketoaldehydes and thus protects cells from ketoaldehyde-mediated formation of advanced glycation end products. The main physiological substrate is the toxic and mutagenic methylglyoxal, which originates from triosephosphates during glycolysis as well as threonine catabolism.
-
-
?
additional information
?
-
-
The glyoxalase system, composed of glyoxalase I and II catalyzes the detoxification of reactive ketoaldehydes and thus protects cells from ketoaldehyde-mediated formation of advanced glycation end products. The main physiological substrate is the toxic and mutagenic methylglyoxal, which originates from triosephosphates during glycolysis as well as threonine catabolism.
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
lactoylglutathione + H2O
D-lactate + glutathione
-
reaction is rate-limiting, methylglyoxal bypass of glycolysis
-
-
r
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate anion
S-acetyltrypanothione + H2O
acetate + trypanothione
-
-
-
?
S-bis-lactoyltrypanothione + 2 H2O
2 D-lactate + trypanothione
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
S-D-lactoylglutathione + H2O
glutathione + D-lactate
S-D-lactoylglutathione + H2O
glutathione + D-lactic acid
-
-
-
r
S-glycolyltrypanothione + H2O
glycolate + trypanothione
-
-
-
?
S-hydroxyglutaryltrypanothione + H2O
hydroxyglutarate + trypanothione + 2 H+
-
-
-
?
S-lactoylglutathionylspermidine + H2O
?
-
-
-
?
S-propionyltrypanothione + H2O
propionate + trypanothione + H+
-
-
-
?
additional information
?
-
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate
-
-
-
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate
-
-
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate
-
-
-
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate
-
-
-
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate
-
-
-
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate
-
-
-
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate anion
-
enzyme is part of the glyoxalase system and involved in detoxification of methylglyoxal
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate anion
-
enzyme is part of the glyoxalase system and involved in detoxification of methylglyoxal
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate anion
-
second step in the glyoxalase system
regeneration of glutathione for the first step in the glyoxalase system
-
ir
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate anion
-
the enzyme is involved in the detoxification process converting reactive dicarbonyl compounds such as methylglyoxal to less reactive hydroxyl acids
-
?
S-(2-hydroxyacyl)glutathione + H2O
glutathione + a 2-hydroxycarboxylate anion
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
second step in the glyoxalase system
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
second step in the glyoxalase system, detoxification of methylglyoxal
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
second step in the glyoxalase system
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
second step in the glyoxalase system, detoxification of methylglyoxal
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
second step in the glyoxalase system
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
second step in the glyoxalase system
-
-
?
S-D-lactoylglutathione + H2O
D-lactate + glutathione
-
second step in the glyoxalase system
-
-
?
S-D-lactoylglutathione + H2O
glutathione + D-lactate
-
-
?
S-D-lactoylglutathione + H2O
glutathione + D-lactate
-
enzyme is involved in the detoxification of methylglyoxal
-
?
S-D-lactoylglutathione + H2O
glutathione + D-lactate
-
enzyme is involved in the detoxification of methylglyoxal
-
?
S-D-lactoylglutathione + H2O
glutathione + D-lactate
enzyme is involved in the detoxification of ketoaldehydes such as methylglyoxal, which is mainly a byproduct of glycolysis
-
?
additional information
?
-
the enzyme participates in the detoxification of cytotoxic and mutagenic 2-oxoaldehydes
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
the enzyme catalyzes the rate limiting step of the glyoxalase pathway
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
the GLX2 gene, which encodes glyoxalase II enzyme, is up-regulated by p63 and p73. Accordingly, a specific responsive element is found in intron 1 of the GLX2 gene, which can be activated and bound by p63 and p73. Upon overexpression, the cytosolic, but not the mitochondrial, GLX2 inhibits the apoptotic response of a cell to methylglyoxal, a by-product of glycolysis. Cells deficient in GLX2 are hypersensitive to methylglyoxal-induced apoptosis. A deficiency in GLX2 enhances the susceptibility of a cell to DNA damage-induced apoptosis in a p53-dependent manner
-
-
?
additional information
?
-
-
the GLX2 gene, which encodes glyoxalase II enzyme, is up-regulated by p63 and p73. Accordingly, a specific responsive element is found in intron 1 of the GLX2 gene, which can be activated and bound by p63 and p73. Upon overexpression, the cytosolic, but not the mitochondrial, GLX2 inhibits the apoptotic response of a cell to methylglyoxal, a by-product of glycolysis. Cells deficient in GLX2 are hypersensitive to methylglyoxal-induced apoptosis. A deficiency in GLX2 enhances the susceptibility of a cell to DNA damage-induced apoptosis in a p53-dependent manner
-
-
?
additional information
?
-
GlxII belongs to the metallo-beta-lactamase superfamily of proteins, in which a zinc-binding motif is conserved
-
-
?
additional information
?
-
the glyoxalase system can detoxify methylglyoxal, a by-product of carbohydrate and lipid metabolism, which can produce toxic effects by reacting with RNA, DNA and proteins
-
-
?
additional information
?
-
The glyoxalase system catalyzes the conversion of toxic methylglyoxal to nontoxic D-lactic acid using glutathione as a coenzyme. Glyoxalase II is a binuclear Zn-enzyme that catalyzes the second step of this conversion, namely the hydrolysis of S-D-lactoylglutathione, which is the product of the glyoxalase I (EC 4.4.15) reaction.
-
-
?
additional information
?
-
-
the glyoxalase system may play an important role in the regulation of cell division and differentiation
-
-
?
additional information
?
-
-
catalytic process involves a water molecule activated by a binuclear metal center containing one zinc atom plus a second bivalent metal ion which could be a zinc or an iron
-
-
?
additional information
?
-
-
glyoxalase system containing glyoxalase I and II catalyzes the conversion of 2-oxoaldehydes into their corresponding 2-hydroxyacids
-
-
?
additional information
?
-
OsglyII gene expression is stimulated within 15 min in response to various abiotic stresses as well as treatment with abscisic acid or salicylic acid
-
-
?
additional information
?
-
-
OsglyII gene expression is stimulated within 15 min in response to various abiotic stresses as well as treatment with abscisic acid or salicylic acid
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
recombinant glyoxalase II hydrolyzes the trypanothione-thioesters of methylglyoxal, glyoxal and 4,5-dioxovalerate, substrates of the classical glyoxalase system, with high efficiency
-
-
?
additional information
?
-
-
recombinant glyoxalase II hydrolyzes the trypanothione-thioesters of methylglyoxal, glyoxal and 4,5-dioxovalerate, substrates of the classical glyoxalase system, with high efficiency
-
-
?
additional information
?
-
The glyoxalase system, composed of glyoxalase I and II catalyzes the detoxification of reactive ketoaldehydes and thus protects cells from ketoaldehyde-mediated formation of advanced glycation end products. The main physiological substrate is the toxic and mutagenic methylglyoxal, which originates from triosephosphates during glycolysis as well as threonine catabolism.
-
-
?
additional information
?
-
-
The glyoxalase system, composed of glyoxalase I and II catalyzes the detoxification of reactive ketoaldehydes and thus protects cells from ketoaldehyde-mediated formation of advanced glycation end products. The main physiological substrate is the toxic and mutagenic methylglyoxal, which originates from triosephosphates during glycolysis as well as threonine catabolism.
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.15 - 0.29
(S)-D-lactoylglutathione
0.009
(S)-D-mandeloylglutathione
-
-
0.086
bis-(lactoyl)trypanothione
3
lactoylglutathione
or above, pH 7.2, 25°C
0.039 - 0.108
mono-(lactoyl)trypanothione
0.152 - 0.283
S-(2-hydroxyacyl)glutathione
0.044 - 0.703
S-(beta-ethoxy-alpha-D-hydroxybutyryl)glutathione
0.054 - 0.841
S-Acetoacetylglutathione
0.034 - 0.83
S-acetylglutathione
0.144
S-acetyltrypanothione
-
0.164
S-bis-lactoyltrypanothione
-
0.06 - 5.782
S-D-lactoylglutathione
0.32
S-D-lactoylgutathione
-
pH 6.5, 30°C, substrate concentration 1.5-3 mM
0.092 - 0.15
S-D-lactoyltrypanothione
0.0166 - 0.0365
S-D-mandeloylglutathione
0.153 - 0.213
S-formylglutathione
0.109
S-glyceroylglutathione
0.07 - 1.16
S-glycolylglutathione
0.265
S-glycolyltrypanothione
-
0.133
S-hydroxyglutaryltrypanothione
-
0.0966
S-L-glyceroylglutathione
-
-
0.0007 - 0.6
S-Lactoylglutathione
0.195
S-lactoylglutathionylspermidine
-
0.014 - 0.0164
S-mandeloylglutathione
0.213 - 1.2
S-propionylglutathione
0.109
S-propionyltrypanothione
-
0.134 - 0.535
S-succinylglutathione
additional information
additional information
-
0.15
(S)-D-lactoylglutathione
-
-
0.177
(S)-D-lactoylglutathione
-
-
0.251
(S)-D-lactoylglutathione
-
-
0.29
(S)-D-lactoylglutathione
-
-
0.086
bis-(lactoyl)trypanothione
pH 7.2, 25°C
0.086
bis-(lactoyl)trypanothione
recombinant enzyme, pH 7.2, 25°C
0.039
mono-(lactoyl)trypanothione
pH 7.2, 25°C
0.098
mono-(lactoyl)trypanothione
-
pH 6.8, 30°C
0.108
mono-(lactoyl)trypanothione
pH 7.2, 25°C
0.108
mono-(lactoyl)trypanothione
recombinant enzyme, pH 7.2, 25°C
0.152
S-(2-hydroxyacyl)glutathione
-
cytosolic isozyme, pH 7.2, 25°C, in presence of dioleoyl phosphatidic acid
0.152
S-(2-hydroxyacyl)glutathione
-
mitochondrial isozyme, pH 7.2, 25°C
0.162
S-(2-hydroxyacyl)glutathione
-
mitochondrial isozyme, pH 7.2, 25°C, in presence of dioleoyl phosphatidic acid
0.169
S-(2-hydroxyacyl)glutathione
-
cytosolic isozyme, pH 7.2, 25°C, in presence of cardiolipin
0.191
S-(2-hydroxyacyl)glutathione
-
cytosolic isozyme, pH 7.2, 25°C, in presence of dipalmitoylphosphatidylserine
0.191
S-(2-hydroxyacyl)glutathione
-
mitochondrial isozyme, pH 7.2, 25°C, in presence of cardiolipin
0.201
S-(2-hydroxyacyl)glutathione
-
cytosolic isozyme, pH 7.2, 25°C
0.255
S-(2-hydroxyacyl)glutathione
-
mitochondrial isozyme, pH 7.2, 25°C, in presence of phosphatidylserine
0.283
S-(2-hydroxyacyl)glutathione
-
mitochondrial isozyme, pH 7.2, 25°C, in presence of dipalmitoylphosphatidylserine
0.044
S-(beta-ethoxy-alpha-D-hydroxybutyryl)glutathione
-
cytosolic enzyme
0.05
S-(beta-ethoxy-alpha-D-hydroxybutyryl)glutathione
-
mitochondrial enzyme
0.703
S-(beta-ethoxy-alpha-D-hydroxybutyryl)glutathione
-
mitochondrial enzyme
0.054
S-Acetoacetylglutathione
-
-
0.116
S-Acetoacetylglutathione
-
-
0.13
S-Acetoacetylglutathione
-
-
0.295
S-Acetoacetylglutathione
-
enzyme from liver
0.296
S-Acetoacetylglutathione
-
-
0.413
S-Acetoacetylglutathione
-
enzyme from intermembrane space
0.634
S-Acetoacetylglutathione
-
matrix enzyme
0.841
S-Acetoacetylglutathione
-
cytosolic enzyme
0.034
S-acetylglutathione
-
-
0.2
S-acetylglutathione
-
-
0.266
S-acetylglutathione
-
-
0.266
S-acetylglutathione
-
enzyme from liver
0.568
S-acetylglutathione
-
cytosolic enzyme
0.6
S-acetylglutathione
-
matrix enzyme
0.603
S-acetylglutathione
-
enzyme from intermembrane space
0.662
S-acetylglutathione
-
mitochondrial enzyme
0.83
S-acetylglutathione
-
-
0.06
S-D-lactoylglutathione
mutant R225A, pH 7.2, 25°C
0.061
S-D-lactoylglutathione
-
0.062
S-D-lactoylglutathione
mutant C140A, pH 7.2, 25°C
0.063
S-D-lactoylglutathione
wild-type enzyme, pH 7.2, 25°C
0.0722
S-D-lactoylglutathione
pH not specified in the publication, temperature not specified in the publication
0.076
S-D-lactoylglutathione
mutant D58C, pH 7.2, 25°C
0.098
S-D-lactoylglutathione
-
-
0.098
S-D-lactoylglutathione
mutant N178A, pH 7.2, 25°C
0.112
S-D-lactoylglutathione
pH not specified in the publication, temperature not specified in the publication
0.114
S-D-lactoylglutathione
-
wild-type, at 25°C, in 100 mM MOPS/NaOH, pH 6.8
0.116
S-D-lactoylglutathione
-
mutant R154K, at 25°C, in 100 mM MOPS/NaOH, pH 6.8
0.12
S-D-lactoylglutathione
recombinant enzyme grown in medium supplemented with Mn2+, pH 7.2, 25°C
0.13
S-D-lactoylglutathione
mutant H54N, pH 7.2, 25°C
0.137
S-D-lactoylglutathione
-
-
0.14
S-D-lactoylglutathione
-
recombinant cytosolic isozyme, medium with Zn added, pH 7.2, 25°C
0.146
S-D-lactoylglutathione
-
-
0.151
S-D-lactoylglutathione
recombinant mutant L9A, pH 7.2, 25°C
0.17
S-D-lactoylglutathione
mutant K142A, pH 7.2, 25°C
0.187
S-D-lactoylglutathione
recombinant enzyme
0.2
S-D-lactoylglutathione
-
recombinant wild-type enzyme, pH 7.1, 37°C
0.21
S-D-lactoylglutathione
-
recombinant cytosolic isozyme, minimal medium, pH 7.2, 25°C
0.22
S-D-lactoylglutathione
recombinant enzyme grown in medium not supplemented with metal ions or supplemented with Fe2+, pH 7.2, 25°C
0.241
S-D-lactoylglutathione
enzyme obtained from minimal medium supplemented with Mn2+
0.256
S-D-lactoylglutathione
recombinant wild-type enzyme, pH 7.2, 25°C
0.268
S-D-lactoylglutathione
recombinant mutant W57D, pH 7.2, 25°C
0.27
S-D-lactoylglutathione
-
-
0.27
S-D-lactoylglutathione
-
enzyme from liver
0.275
S-D-lactoylglutathione
-
mutant R154M, at 25°C, in 100 mM MOPS/NaOH, pH 6.8
0.288
S-D-lactoylglutathione
recombinant mutant K65A, pH 7.2, 25°C
0.295
S-D-lactoylglutathione
enzyme obtained from minimal medium supplemented with Zn2+
0.2982
S-D-lactoylglutathione
at pH 7.5 and 25°C
0.318
S-D-lactoylglutathione
recombinant mutant W57N, pH 7.2, 25°C
0.384
S-D-lactoylglutathione
-
matrix enzyme
0.408
S-D-lactoylglutathione
enzyme otained from LB medium
0.433
S-D-lactoylglutathione
-
cytosolic enzyme
0.439
S-D-lactoylglutathione
Y291R/C294K mutant protein, pH not specified in the publication, temperature not specified in the publication
0.44
S-D-lactoylglutathione
-
mitochondrial enzyme
0.463
S-D-lactoylglutathione
enzyme obtained from minimal medium supplemented with Fe2+
0.484
S-D-lactoylglutathione
-
-
0.5
S-D-lactoylglutathione
-
at pH 7.5 and 30°C
0.598
S-D-lactoylglutathione
-
enzyme from intermembrane space
0.6
S-D-lactoylglutathione
mutant R248W, pH 7.2, 25°C
0.6
S-D-lactoylglutathione
-
recombinant cytosolic isozyme, medium with Fe added, pH 7.2, 25°C
1.6
S-D-lactoylglutathione
-
recombinant mutant Y175F, pH 7.1, 37°C
2.551
S-D-lactoylglutathione
-
mutant R257Q, at 25°C, in 100 mM MOPS/NaOH, pH 7.4
2.867
S-D-lactoylglutathione
-
mutant K260D, at 25°C, in 100 mM MOPS/NaOH, pH 6.8
3
S-D-lactoylglutathione
above, recombinant enzyme, pH 7.2, 25°C
4.308
S-D-lactoylglutathione
-
mutant K260Q, at 25°C, in 100 mM MOPS/NaOH, pH 6.8
5.782
S-D-lactoylglutathione
-
mutant R257D, at 25°C, in 100 mM MOPS/NaOH, pH 6.8
0.092
S-D-lactoyltrypanothione
wild type protein, pH not specified in the publication, temperature not specified in the publication
0.15
S-D-lactoyltrypanothione
Y291R/C294K mutant protein, pH not specified in the publication, temperature not specified in the publication
0.0166
S-D-mandeloylglutathione
pH not specified in the publication, temperature not specified in the publication
0.0218
S-D-mandeloylglutathione
-
-
0.026
S-D-mandeloylglutathione
enzyme from erythrocytes
0.029
S-D-mandeloylglutathione
recombinant enzyme
0.0365
S-D-mandeloylglutathione
pH not specified in the publication, temperature not specified in the publication
0.153
S-formylglutathione
-
-
0.153
S-formylglutathione
-
enzyme from liver
0.213
S-formylglutathione
-
cytosolic enzyme
0.109
S-glyceroylglutathione
-
-
0.109
S-glyceroylglutathione
-
enzyme from liver
0.07
S-glycolylglutathione
-
-
0.07
S-glycolylglutathione
-
enzyme from liver
0.237
S-glycolylglutathione
-
-
1.16
S-glycolylglutathione
-
brain
0.0007
S-Lactoylglutathione
-
-
0.086
S-Lactoylglutathione
-
-
0.1
S-Lactoylglutathione
25°C
0.12
S-Lactoylglutathione
pH 7.0
0.139
S-Lactoylglutathione
-
pH 7.2, 25°C, growth on minimal medium without in presence of zinc
0.172
S-Lactoylglutathione
enzyme from erythrocytes
0.18
S-Lactoylglutathione
-
-
0.18
S-Lactoylglutathione
-
enzyme from erythrocytes
0.19
S-Lactoylglutathione
-
-
0.19
S-Lactoylglutathione
-
enzyme from liver
0.19
S-Lactoylglutathione
37°C
0.209
S-Lactoylglutathione
-
pH 7.2, 25°C, growth on minimal medium without added metal ion
0.21
S-Lactoylglutathione
-
enzyme from liver
0.225
S-Lactoylglutathione
25°C
0.254
S-Lactoylglutathione
-
pH and temperature not specified in the publication, Vmax: 1 mmol/min/mg
0.304
S-Lactoylglutathione
-
enzyme from brain
0.325
S-Lactoylglutathione
-
enzyme from calf brain
0.391
S-Lactoylglutathione
25°C, pH 7.2
0.463
S-Lactoylglutathione
37°C, mutant Y185F
0.6
S-Lactoylglutathione
-
pH 7.2, 25°C, growth on minimal medium in presence of iron
0.014
S-mandeloylglutathione
-
-
0.014
S-mandeloylglutathione
-
enzyme from erythrocytes
0.015
S-mandeloylglutathione
-
enzyme from brain
0.016
S-mandeloylglutathione
-
enzyme from liver
0.0164
S-mandeloylglutathione
-
-
0.213
S-propionylglutathione
-
-
0.213
S-propionylglutathione
-
enzyme from liver
0.214
S-propionylglutathione
-
cytosolic enzyme
0.242
S-propionylglutathione
-
mitochondrial enzyme
0.378
S-propionylglutathione
-
mitochondrial enzyme
0.792
S-propionylglutathione
-
enzyme from intermembrane space
1.2
S-propionylglutathione
-
matrix enzyme
0.134
S-succinylglutathione
-
-
0.16
S-succinylglutathione
-
mitochondrial enzyme
0.186
S-succinylglutathione
-
enzyme from intermembrane space
0.2
S-succinylglutathione
-
-
0.2
S-succinylglutathione
-
enzyme from liver
0.25
S-succinylglutathione
-
-
0.25
S-succinylglutathione
-
-
0.325
S-succinylglutathione
-
cytosolic enzyme
0.535
S-succinylglutathione
-
matrix enzyme
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
kinetics
-
additional information
additional information
-
Km-values of wild-type and mutant enzymes
-
additional information
additional information
-
kinetics in presence of liposomes consisting of different phospholipids
-
additional information
additional information
-
kinetics in presence of liposomes consisting of different phospholipids
-
additional information
additional information
-
kinetics of the enzyme in situ, cells being permeabilized by digitonin
-
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vander Jagt, D.L.
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Proteins
41
33-39
2000
Bos taurus, Homo sapiens
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Escherichia coli glyoxalase II is a binuclear zinc-dependent metalloenzyme
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Biochemical and structural characterization of Salmonella typhimurium glyoxalase II: new insights into metal ion selectivity
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Catalysis and structural properties of Leishmania infantum glyoxalase II: trypanothione specificity and phylogeny
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Leishmania infantum (Q2PYN0), Leishmania infantum
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Overexpression of glyoxalase system enzymes in human kidney tumor
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Rattus norvegicus (O35952)
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Glyoxalase II, a detoxifying enzyme of glycolysis byproduct methylglyoxal and a target of p63 and p73, is a pro-survival factor of the p53 family
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Homo sapiens (Q16775), Homo sapiens
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Characterization and functional validation of glyoxalase II from rice
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Design and evolution of new catalytic activity with an existing protein scaffold
Science
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Homo sapiens (Q16775)
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Enhancing salt tolerance in a crop plant by overexpression of glyoxalase II
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Formate excretion in urine of rats fed dimethylaminoazobenzene-rich diets: the possibility of formate formation from D-lactate
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Rattus norvegicus
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Molecular enzymology of the glyoxalase system
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