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Information on EC 3.1.2.22 - palmitoyl[protein] hydrolase and Organism(s) Canis lupus familiaris and UniProt Accession Q5JZR0

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.2 Thioester hydrolases
                3.1.2.22 palmitoyl[protein] hydrolase
IUBMB Comments
Specific for long-chain thioesters of fatty acids. Hydrolyses fatty acids from S-acylated cysteine residues in proteins, palmitoyl cysteine and palmitoyl-CoA.
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This record set is specific for:
Canis lupus familiaris
UNIPROT: Q5JZR0
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Word Map
The taxonomic range for the selected organisms is: Canis lupus familiaris
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
palmitoyl-protein thioesterase, palmitoyl-protein thioesterase 1, palmitoyl protein thioesterase, palmitoyl protein thioesterase 1, palmitoyl-protein thioesterase-1, palmitoyl protein thioesterase-1, acyl-protein thioesterase 1, lysophospholipase 1, palmitoyl-thioesterase, palmitoyl protein thioesterase-2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
palmitoyl protein thioesterase 1
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Acyl protein thioester hydrolase
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-
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G14
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GenBank AF020543-derived protein GI 2501961
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GenBank L42809-derived protein GI 1160967
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Hydrolase, acyl protein thioester
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-
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Hydrolase, acyl protein thioester (cattle clone pBovPPT-18 precursor reduced)
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-
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Hydrolase, acyl protein thioester (cattle pBovPPT-25 precursor reduced)
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-
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Hydrolase, acyl protein thioester (human clone B lysosome-associated isoenzyme 2)
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-
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Hydrolase, acyl protein thioester (human clone pHuPPT-5')
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-
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Hydrolase, acyl protein thioester (ox clone pBovPPT-18 precursor reduced)
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-
-
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Hydrolase, acyl protein thioester (ox pBovPPT-25 precursor reduced)
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-
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Hydrolase, acyl protein thioester (rat clone pRatPPT-44 precursor reduced)
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-
-
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Palmitoyl-protein thioesterase
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-
-
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Palmitoyl-protein thioesterase (bovine clone pBovPPT-17 precursor)
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-
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Palmitoyl-protein thioesterase (bovine clone pBovPPT-25 precursor)
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Palmitoyl-protein thioesterase (human clone pHuPPT-5')
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-
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Palmitoyl-protein thioesterase (rat clone pRatPPT-44 precursor)
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-
-
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Palmitoyl-protein thioesterase PPT2 (human clone B lysosome associated)
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-
-
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PPT
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-
-
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PPT1
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of thioester
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-
-
-
PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
palmitoyl[protein] hydrolase
Specific for long-chain thioesters of fatty acids. Hydrolyses fatty acids from S-acylated cysteine residues in proteins, palmitoyl cysteine and palmitoyl-CoA.
CAS REGISTRY NUMBER
COMMENTARY hide
150605-49-5
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158210-90-3
hydrolase, acyl protein thioester (rat clone pRatPPT-44 precursor reduced) /palmitoyl-protein thioesterase (rat clone pRatPPT-44 precursor)
158210-92-5
hydrolase, acyl protein thioester (cattle clone pBovPPT-18 precursor reduced) /hydrolase, acyl protein thioester (ox clone pBovPPT-18 precursor reduced) /palmitoyl-protein thioesterase (bovine clone pBovPPT-17 precursor)
158210-93-6
hydrolase, acyl protein thioester (cattle pBovPPT-25 precursor reduced) /hydrolase, acyl protein thioester (ox pBovPPT-25 precursor reduced) /palmitoyl-protein thioesterase (bovine clone pBovPPT-25 precursor)
179801-10-6
hydrolase, acyl protein thioester (human clone pHuPPT-5') /GenBank L42809-derived protein GI 1160967 /palmitoyl-protein thioesterase (human clone pHuPPT-5')
199619-79-9
hydrolase, acyl protein thioester (human clone B lysosome-associated isoenzyme 2) /genBank AF020543-derived protein GI 2501961 /palmitoyl-protein thioesterase PPT2 (human clone B lysosome associated)
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-methylumbelliferyl 6-deoxy-6-thiopalmitoyl-beta-D-glucopyranoside + H2O
4-methylumbelliferyl 6-deoxy-6-thio-beta-D-glucopyranoside + palmitate
show the reaction diagram
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-
-
?
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0055
substrate 4-methylumbelliferyl 6-deoxy-6-thiopalmitoyl-beta-D-glucopyranoside, cerebral cortex gray matter lysate, pH not specified in the publication, temperature not specified in the publication
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Miniature Dachshund
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
neuronal ceroid lipofuscinoses-like signs caused by single nucleotide insertion in exon 8 (homozygous)
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
Q5JZR0_CANLF
306
0
34183
TrEMBL
Secretory Pathway (Reliability: 1)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sanders, D.N.; Farias, F.H.; Johnson, G.S.; Chiang, V.; Cook, J.R.; OBrien, D.P.; Hofmann, S.L.; Lu, J.Y.; Katz, M.L.
A mutation in canine PPT1 causes early onset neuronal ceroid lipofuscinosis in a Dachshund
Mol. Genet. Metab.
100
349-356
2010
Canis lupus familiaris (Q5JZR0), Canis lupus familiaris
Manually annotated by BRENDA team