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2-methylstearoyl-CoA + H2O
CoA + 2-methylstearate
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
synthetic substrate
-
-
?
2-trans-decenoyl-CoA + H2O
CoA + 2-trans-decenoate
-
-
?
3-hydroxy-3-methyl glutaryl-CoA + H2O
CoA + 3-hydroxy-3-methyl glutarate
-
-
-
?
3-hydroxy-3-methylglutaryl-CoA + H2O
CoA + 3-hydroxy-3-methylglutarate
-
-
?
3-hydroxybutyryl-CoA + H2O
CoA + 3-hydroxybutanoate
-
reaction at 4.3% the rate of acetoacetyl-CoA hydrolysis
-
-
?
3-hydroxybutyryl-CoA + H2O
CoA + 3-hydroxybutyrate
-
-
-
?
3-hydroxydecanoyl-CoA + H2O
CoA + 3-hydroxydecanoate
3-hydroxyhexadecanoyl-CoA + H2O
CoA + 3-hydroxyhexadecanoate
-
-
-
?
3-hydroxypalmitoyl-CoA + H2O
CoA + 3-hydroxypalmitate
-
-
?
3-oxodecanoyl-CoA + H2O
CoA + 3-oxodecanoate
-
-
-
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
-
-
-
-
?
acetoacetyl-CoA + H2O
CoA + acetoacetate
acetyl-CoA + H2O
CoA + acetate
acyl-CoA + H2O
CoA + a carboxylate
arachidonoyl-CoA + H2O
arachidonic acid + CoA
arachidonoyl-CoA + H2O
CoA + arachidonate
arachidoyl-CoA + H2O
CoA + arachidate
benzoyl-CoA + H2O
CoA + benzoate
butyryl-CoA + H2O
butanoate + CoA
-
-
?
butyryl-[acyl-carrier protein] + H2O
butanoate + acyl-carrier protein
-
-
-
?
chenodeoxycholoyl-CoA + H2O
CoA + chenodeoxycholate
-
-
?
chenodeoxycholoyl-CoA + H2O
CoA + chenodeoxycholoate
cholesteryl oleate + H2O
cholesterol + oleate
-
-
-
-
?
choloyl-CoA + H2O
CoA + cholate
best substrate
-
?
choloyl-CoA + H2O
CoA + choloate
cis-methylene-9,10-hexadecanoyl-CoA + H2O
CoA + cis-methylene-9,10-hexadecanoate
-
-
-
?
cis-palmitoleoyl-CoA + H2O
CoA + palmitoleate
-
-
-
?
cis-vaccenoyl-CoA + H2O
CoA + cis-vaccenate
-
-
-
?
clofibroyl-CoA + H2O
CoA + clofibrate
-
-
?
crotonyl-CoA + H2O
CoA + crotonate
decanoyl-CoA + H2O
CoA + decanoate
dipalmitoylglycero-3-phosphocholine + H2O
?
-
-
-
-
?
DL-palmitoyl carnitine + H2O
palmitate + DL-carnitine
-
-
-
-
?
docosahexaenoyl-CoA + H2O
CoA + docosahexaenoate
-
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
eicosanoyl-CoA + H2O
CoA + eicosanoate
-
-
-
-
?
eicosanoyl-CoA + H2O
CoA + eicosanoic acid
-
-
-
?
eicosapentaenoyl-CoA + H2O
CoA + eicosapentaenoate
gamma-linolenoyl-CoA + H2O
CoA + gamma-linolenoate
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
hexanoyl-CoA + H2O
CoA + hexanoate
hexanoyl-CoA + H2O
CoA + n-hexanoate
-
-
?
lauroyl-CoA + H2O
CoA + laurate
linolenoyl-CoA + H2O
CoA + linolenoate
linoleoyl-CoA + H2O
CoA + linoleate
linoleoyl-CoA + H2O
CoA + linoleoate
Q8GYW7
-
-
?
malonyl-CoA + H2O
CoA + malonate
malonyl-CoA + H2O
malonate + CoA
-
-
-
?
monolauroyl sucrose + H2O
lauroate + sucrose
-
-
-
-
?
monoolein + H2O
oleate + glycerol
-
-
-
-
?
monopalmitoyl sucrose + H2O
palmitate + sucrose
-
-
-
-
?
myristoleoyl-CoA + H2O
myristoleoate + CoA
myristoyl-CoA + H2O
CoA + myristate
n-butyryl-CoA + H2O
CoA + n-butanoate
N-carbobenzoxy-L-tyrosine p-nitrophenyl ester + H2O
N-carbobenzoxy-L-tyrosine + p-nitrophenol
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
octanoyl-CoA + H2O
CoA + octanoate
oleoyl pantetheine + H2O
oleate + pantetheine
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
oleoyl-CoA + H2O
CoA + oleic acid
-
-
-
?
oleyl-[acyl-carrier protein] + H2O
oleate + acyl-carrier protein
-
-
-
-
?
p-nitrophenyl butyrate + H2O
p-nitrophenol + butanoate
-
-
-
?
p-nitrophenyl butyrate + H2O
p-nitrophenol + butyrate
-
-
-
?
palmitoleoyl-CoA
CoA + CoA + palmitoleoate
Q8GYW7
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleate
palmitoleoyl-CoA + H2O
CoA + palmitoleic acid
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
palmitoyl-CoA + H2O
CoA + palmitate
palmitoyl-CoA + H2O
palmitate + CoA
-
-
-
?
polyoxyethylene sorbitan monooleate + H2O
?
-
-
-
-
?
propionyl-CoA + H2O
CoA + propionate
propionyl-[acyl-carrier protein] + H2O
propionate + acyl-carrier protein
-
-
-
?
prostaglandin F2alpha + H2O
?
-
-
?
prostaglandin F2alpha-CoA + H2O
prostaglandin F2alpha + CoA
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
succinyl-CoA + H2O
CoA + succinate
-
reaction at 33% the rate of acetoacetyl-CoA hydrolysis
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
tetradecylthioacetyl-CoA + H2O
CoA + tetradecylthioacetate
-
best substrate
-
-
?
tetradecylthiopropionyl-CoA + H2O
CoA + tetradecylthiopropionate
-
-
-
-
?
trihydroxycoprostanoyl-CoA + H2O
CoA + trihydroxycoprostanoate
-
-
?
tripalmitoylglycerol + H2O
?
-
-
-
-
?
vaccenoyl-CoA + H2O
CoA + vaccenoate
additional information
?
-
3-hydroxydecanoyl-CoA + H2O
CoA + 3-hydroxydecanoate
-
-
-
-
?
3-hydroxydecanoyl-CoA + H2O
CoA + 3-hydroxydecanoate
-
reaction at 1.4% the rate of acetoacetyl-CoA hydrolysis
-
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
-
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
-
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
involved in pristanic acid beta-oxidation, scheme of the pathway
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
hydrolysis allows transport of 4,8-dimethylnonanoate from peroxisomes to mitochondria for full oxidation
-
?
acetoacetyl-CoA + H2O
CoA + acetoacetate
-
-
?
acetoacetyl-CoA + H2O
CoA + acetoacetate
-
8% activity compared to palmitoyl-CoA
-
?
acetoacetyl-CoA + H2O
CoA + acetoacetate
-
best substrate
-
-
?
acetyl-CoA + H2O
CoA + acetate
-
-
-
-
?
acetyl-CoA + H2O
CoA + acetate
-
-
?
acetyl-CoA + H2O
CoA + acetate
-
-
-
-
?
acetyl-CoA + H2O
CoA + acetate
-
no activity
-
-
?
acetyl-CoA + H2O
CoA + acetate
poor substrate
-
?
acetyl-CoA + H2O
CoA + acetate
-
reaction at 33% the rate of acetoacetyl-CoA hydrolysis
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
broad specificity for medium-chain to long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
Q8GYW7
prefers unsaturated acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
Q8GYW7
long-chain fatty-acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
Q8GYW7
enzyme is not linked to fatty acid oxidation
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
broad specificity for medium-chain to long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
saturated and unsaturated acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain fatty-acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
broad specificity for medium-chain to long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
broad specificity for medium-chain to long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
preference for unsaturated acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
acyl-CoA of chain length C8-C18
-
?
acyl-CoA + H2O
CoA + a carboxylate
long-chain fatty-acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
long-chain fatty-acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
involved in fatty acid metabolism
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain fatty-acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain fatty-acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain fatty-acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain to very-long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
broad specificity for medium-chain to long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
broad specificity for medium-chain to long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
saturated and unsaturated acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
specific for very-long acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain fatty-acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain fatty-acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain fatty-acyl-CoA
-
-
ir
acyl-CoA + H2O
CoA + a carboxylate
-
specific for acyl-CoA, S-palmitoyl-glutathione and S-palmitoyl-cysteine are no substrates
-
?
acyl-CoA + H2O
CoA + a carboxylate
involved in fatty acid metabolism
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
arachidonoyl-CoA + H2O
arachidonic acid + CoA
-
-
-
?
arachidonoyl-CoA + H2O
arachidonic acid + CoA
-
enzyme is involved in steroidogenesis, overview
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
Q8GYW7
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
most effective substrate
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
involved in cholesterol metabolism
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
enzyme is responsible for the mobilization of stored arachidonic acid in cells
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
i.e. all-cis-5,8,11,14-eicosatetranoate
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
enzyme provides arachidonic acid for prostaglandin synthesis in microsomes of kidney medulla
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
i.e. all-cis-5,8,11,14-eicosatetranoate
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
enzyme is responsible for the mobilization of stored arachidonic acid in cells
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
regulation, e.g. in the heart, of the enzyme is performed via beta-adrenergic receptors and their antagonists, e.g. actinomycin D
-
?
arachidoyl-CoA + H2O
CoA + arachidate
-
-
-
?
arachidoyl-CoA + H2O
CoA + arachidate
-
-
?
benzoyl-CoA + H2O
CoA + benzoate
-
-
-
?
benzoyl-CoA + H2O
CoA + benzoate
-
-
-
?
benzoyl-CoA + H2O
CoA + benzoate
-
-
-
?
chenodeoxycholoyl-CoA + H2O
CoA + chenodeoxycholoate
activity is PPARalpha-inducible
-
-
?
chenodeoxycholoyl-CoA + H2O
CoA + chenodeoxycholoate
bile acid derivative substrate
-
-
?
choloyl-CoA + H2O
CoA + choloate
activity is PPARalpha-inducible
-
-
?
choloyl-CoA + H2O
CoA + choloate
bile acid derivative substrate
-
-
?
crotonyl-CoA + H2O
CoA + crotonate
-
-
-
?
crotonyl-CoA + H2O
CoA + crotonate
-
-
-
?
crotonyl-CoA + H2O
CoA + crotonate
-
i.e. [trans]-2-butenoyl-CoA, reaction at 9.4% the rate of acetoacetyl-CoA hydrolysis
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
reaction at 89% the rate of acetoacetyl-CoA hydrolysis
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
Q8GYW7
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
Q8GYW7
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
best substrate
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
eicosapentaenoyl-CoA + H2O
CoA + eicosapentaenoate
-
-
-
?
eicosapentaenoyl-CoA + H2O
CoA + eicosapentaenoate
-
-
-
?
eicosapentaenoyl-CoA + H2O
CoA + eicosapentaenoate
-
-
-
-
?
gamma-linolenoyl-CoA + H2O
CoA + gamma-linolenoate
-
best substrate
-
-
?
gamma-linolenoyl-CoA + H2O
CoA + gamma-linolenoate
-
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
best substrate
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
preferred substrate
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
ir
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
ir
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
best substrate
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
best substrate
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
best substrate
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
ir
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
reaction at 60% the rate of acetoacetyl-CoA hydrolysis
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
poor substrate
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
poor substrate
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
?
lauroyl-CoA + H2O
CoA + laurate
Q8GYW7
-
-
?
lauroyl-CoA + H2O
CoA + laurate
-
-
-
?
lauroyl-CoA + H2O
CoA + laurate
-
-
-
-
?
lauroyl-CoA + H2O
CoA + laurate
-
-
?
lauroyl-CoA + H2O
CoA + laurate
-
-
-
?
lauroyl-CoA + H2O
CoA + laurate
-
-
-
?
linolenoyl-CoA + H2O
CoA + linolenoate
-
-
-
-
?
linolenoyl-CoA + H2O
CoA + linolenoate
-
-
-
-
?
linoleoyl-CoA + H2O
CoA + linoleate
-
-
-
-
?
linoleoyl-CoA + H2O
CoA + linoleate
-
-
-
-
?
linoleoyl-CoA + H2O
CoA + linoleate
-
-
?
linoleoyl-CoA + H2O
CoA + linoleate
-
-
-
?
linoleoyl-CoA + H2O
CoA + linoleate
-
-
-
-
?
malonyl-CoA + H2O
CoA + malonate
-
-
-
-
?
malonyl-CoA + H2O
CoA + malonate
-
-
?
malonyl-CoA + H2O
CoA + malonate
-
-
?
myristoleoyl-CoA + H2O
myristoleoate + CoA
-
-
-
-
?
myristoleoyl-CoA + H2O
myristoleoate + CoA
-
-
?
myristoyl-CoA + H2O
CoA + myristate
Q8GYW7
-
-
?
myristoyl-CoA + H2O
CoA + myristate
-
highly preferred substrate
-
?
myristoyl-CoA + H2O
CoA + myristate
-
highly preferred substrate, temperature regulated activity, mechanism
-
?
myristoyl-CoA + H2O
CoA + myristate
-
-
-
-
?
myristoyl-CoA + H2O
CoA + myristate
-
-
?
myristoyl-CoA + H2O
CoA + myristate
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
poor substrate
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
no activity
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
reaction at 81% the rate of acetoacetyl-CoA hydrolysis
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
preferred substrate
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
preferred substrate
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
Q8GYW7
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
Q8GYW7
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
just slowly hydrolyzed
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
i.e. [cis]-9-octadecenoyl-CoA, reaction at 40% the rate of acetoacetyl-CoA hydrolysis
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleate
Q8GYW7
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleate
Q8GYW7
activity of ACH2 is not linked to fatty acid oxidation
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
Q8GYW7
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
Q8GYW7
best substrate
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
-
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
-
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
Q8GYW7
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
ligand-binding pocket of the thioesterase domain encompasses the catalytic triad of Ser2308, His2481, Asp2338. The hydrophobic interactions are the major decisive factor for the optimal binding of the alphatic chain of palmitate
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
broad substrate specificity for long-chain acyl-CoA substrates
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
the enzyme affects specifically cellular systems and functions, but not all acyl-CoA-utilizing processes, overexpression leads to reduction of growth rate but not to phospholipid synthesis
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
80783, 80785, 80791, 94478, 171023, 646115, 646125, 646128, 646129, 646131, 646134, 646140, 646141, 646144, 646162, 646164, 646167, 646169, 646171, 646173 -
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
propionyl-CoA + H2O
CoA + propionate
-
-
?
propionyl-CoA + H2O
CoA + propionate
-
-
-
-
?
propionyl-CoA + H2O
CoA + propionate
-
-
?
stearoyl-CoA + H2O
CoA + stearate
Q8GYW7
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
specific for
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
best substrate
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
best substrate
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
best substrate
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
best substrate
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
vaccenoyl-CoA + H2O
CoA + vaccenoate
-
-
-
-
?
vaccenoyl-CoA + H2O
CoA + vaccenoate
-
i.e. [trans]-11-octadecenoyl-CoA, preferred substrate of unsaturated acyl-CoA
-
-
?
vaccenoyl-CoA + H2O
CoA + vaccenoate
-
cis-isomer
-
-
?
additional information
?
-
-
substrate specificity alters with pH
-
-
?
additional information
?
-
-
broad substrate specificity, preference for long-chain unsaturated fatty acids
-
?
additional information
?
-
Q8GYW7
broad substrate specificity, preference for long-chain unsaturated fatty acids
-
?
additional information
?
-
-
no activity with short-chain acyl-CoA substrates
-
?
additional information
?
-
-
extreme accumulation, 28fold increased compared to 0°C, of myristoyl-CoA in cells at nonpermissive temperature close to 20°C, causing growth arrest
-
-
?
additional information
?
-
decanoyl pantetheine is no substrate
-
-
?
additional information
?
-
-
decanoyl pantetheine is no substrate
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
no sufficient evidence that acyl-CoA is also the likely substrate in vivo
-
-
?
additional information
?
-
-
enzyme binds tightly and specifically to HIV-1 Nef protein, overview
-
-
?
additional information
?
-
enzyme might play an important role in prevention of CoA sequestration and in facilitating excretion of chain-shortened carboxylic acids, enzyme has a key regulatory function in peroxisomal lipid metabolism
-
?
additional information
?
-
-
sterol regulatory element-binding protein-2 modulates human brain acyl-CoA hydrolase gene transcription
-
-
?
additional information
?
-
-
the ligand binding pocket of the thioesterase domain is a decisive factor in chain length specificity
-
-
?
additional information
?
-
-
docking studies to the pocket of the catalytic triad Ser 2308, His 2481, and Asp 2338, using palmitate, and fatty acids with chain lengths of 12 to 20 carbon atoms. The ligand binding pocket of the thioesterase domain is a decisive factor in chain length specificity. Binding of palmitate results in the most favorable binding free enrgy among the fatty acids tested. The experimentally amino acids of the catalytic triad Ser2308, His2481, and Asp2338 are located very close to the carboxyl group of palmitate. The close location of Arg2482 to the carboxyl group of palmitate and the catalytic triad implies an important role of this residue in catalysis
-
-
?
additional information
?
-
broad chain length specificity
-
?
additional information
?
-
-
broad chain length specificity
-
?
additional information
?
-
-
enzyme regulation
-
?
additional information
?
-
-
enzyme regulation by dietary manipulation
-
-
?
additional information
?
-
enzyme might play an important role in prevention of CoA sequestration and in facilitating excretion of chain-shortened carboxylic acids, enzyme has a key regulatory function in peroxisomal lipid metabolism
-
?
additional information
?
-
-
enzyme might play an important role in prevention of CoA sequestration and in facilitating excretion of chain-shortened carboxylic acids, enzyme has a key regulatory function in peroxisomal lipid metabolism
-
?
additional information
?
-
-
isozyme CTE-I: diurnal regulation and regulation by fat content of the diet
-
?
additional information
?
-
the enzyme plays a role in spermatogenesis
-
-
?
additional information
?
-
-
the enzyme plays a role in spermatogenesis
-
-
?
additional information
?
-
role in eicosanoid synthesis and inflammation
-
-
?
additional information
?
-
-
role in eicosanoid synthesis and inflammation
-
-
?
additional information
?
-
-
PPT1-knockout mice, PPT1 deficiency causes persistent membrane anchorage of the palmitoylated synaptic vesicle proteins, which hinder the recycling of the vesicle components that normally fuse with the presynaptic plasma membrane during synaptic vesicle exocytosis
-
-
?
additional information
?
-
no activity with octanoyl-CoA
-
-
?
additional information
?
-
-
no activity with octanoyl-CoA
-
-
?
additional information
?
-
enzyme assays reveal that Orf6 has a higher specific activity toward long-chain fatty acyl-CoA substrates (palmitoyl-CoA and eicosapentaenoyl-CoA) than toward short-chain or aromatic acyl-CoA substrates
-
-
?
additional information
?
-
-
enzyme assays reveal that Orf6 has a higher specific activity toward long-chain fatty acyl-CoA substrates (palmitoyl-CoA and eicosapentaenoyl-CoA) than toward short-chain or aromatic acyl-CoA substrates
-
-
?
additional information
?
-
enzyme assays reveal that Orf6 has a higher specific activity toward long-chain fatty acyl-CoA substrates (palmitoyl-CoA and eicosapentaenoyl-CoA) than toward short-chain or aromatic acyl-CoA substrates
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
no activity with malonyl-CoA, ligneceroyl-CoA, and nervonoyl-CoA
-
-
?
additional information
?
-
-
differential regulation of distinct ACSl isoforms at the transcriptional level
-
-
?
additional information
?
-
involved in the biosynthesis of the polyketide pikromycin
-
-
?
additional information
?
-
-
involved in the biosynthesis of the polyketide pikromycin
-
-
?
additional information
?
-
-
no substrates are malonyl-CoA, acetoacetyl glutathione, acetoacetyl N-acetylcysteamine or acetoacetyl pantetheine
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
acyl-CoA + H2O
CoA + a carboxylate
arachidonoyl-CoA + H2O
arachidonic acid + CoA
-
enzyme is involved in steroidogenesis, overview
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
myristoyl-CoA + H2O
CoA + myristate
-
highly preferred substrate, temperature regulated activity, mechanism
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleate
Q8GYW7
activity of ACH2 is not linked to fatty acid oxidation
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
stearoyl-CoA + H2O
CoA + stearate
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
?
additional information
?
-
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
-
-
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
involved in pristanic acid beta-oxidation, scheme of the pathway
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
hydrolysis allows transport of 4,8-dimethylnonanoate from peroxisomes to mitochondria for full oxidation
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
Q8GYW7
enzyme is not linked to fatty acid oxidation
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
involved in fatty acid metabolism
-
?
acyl-CoA + H2O
CoA + a carboxylate
involved in fatty acid metabolism
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
involved in cholesterol metabolism
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
enzyme is responsible for the mobilization of stored arachidonic acid in cells
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
enzyme provides arachidonic acid for prostaglandin synthesis in microsomes of kidney medulla
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
enzyme is responsible for the mobilization of stored arachidonic acid in cells
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
regulation, e.g. in the heart, of the enzyme is performed via beta-adrenergic receptors and their antagonists, e.g. actinomycin D
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
preferred substrate
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
reaction at 60% the rate of acetoacetyl-CoA hydrolysis
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
the enzyme affects specifically cellular systems and functions, but not all acyl-CoA-utilizing processes, overexpression leads to reduction of growth rate but not to phospholipid synthesis
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
80783, 80785, 80791, 94478, 171023, 646115, 646125, 646128, 646129, 646131, 646134, 646140, 646141, 646144, 646162, 646164, 646167, 646169, 646171, 646173 -
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
?
additional information
?
-
-
extreme accumulation, 28fold increased compared to 0°C, of myristoyl-CoA in cells at nonpermissive temperature close to 20°C, causing growth arrest
-
-
?
additional information
?
-
-
no sufficient evidence that acyl-CoA is also the likely substrate in vivo
-
-
?
additional information
?
-
-
enzyme binds tightly and specifically to HIV-1 Nef protein, overview
-
-
?
additional information
?
-
enzyme might play an important role in prevention of CoA sequestration and in facilitating excretion of chain-shortened carboxylic acids, enzyme has a key regulatory function in peroxisomal lipid metabolism
-
?
additional information
?
-
-
sterol regulatory element-binding protein-2 modulates human brain acyl-CoA hydrolase gene transcription
-
-
?
additional information
?
-
-
enzyme regulation
-
?
additional information
?
-
-
enzyme regulation by dietary manipulation
-
-
?
additional information
?
-
enzyme might play an important role in prevention of CoA sequestration and in facilitating excretion of chain-shortened carboxylic acids, enzyme has a key regulatory function in peroxisomal lipid metabolism
-
?
additional information
?
-
-
enzyme might play an important role in prevention of CoA sequestration and in facilitating excretion of chain-shortened carboxylic acids, enzyme has a key regulatory function in peroxisomal lipid metabolism
-
?
additional information
?
-
-
isozyme CTE-I: diurnal regulation and regulation by fat content of the diet
-
?
additional information
?
-
the enzyme plays a role in spermatogenesis
-
-
?
additional information
?
-
-
the enzyme plays a role in spermatogenesis
-
-
?
additional information
?
-
role in eicosanoid synthesis and inflammation
-
-
?
additional information
?
-
-
role in eicosanoid synthesis and inflammation
-
-
?
additional information
?
-
-
PPT1-knockout mice, PPT1 deficiency causes persistent membrane anchorage of the palmitoylated synaptic vesicle proteins, which hinder the recycling of the vesicle components that normally fuse with the presynaptic plasma membrane during synaptic vesicle exocytosis
-
-
?
additional information
?
-
-
differential regulation of distinct ACSl isoforms at the transcriptional level
-
-
?
additional information
?
-
involved in the biosynthesis of the polyketide pikromycin
-
-
?
additional information
?
-
-
involved in the biosynthesis of the polyketide pikromycin
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-acyl-sn-glycerol-3-phosphocholine
-
competitive inhibition at low concentration of palmitoyl-CoA
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
-
23% inhibition at 10 mM
13-hydroperoxyoctadecadienoic acid
-
only the mitochondrial enzyme form is inhibited, not the cytosolic one
2,2'-(decane-1,10-diyldisulfanediyl)diacetic acid
-
palmitoyl-CoA hydrolase activity, L-fraction and peroxisomes, especially of 3-thia fatty acids treated rats
2,4-dichlorophenoxyacetate
-
reduced activity in microsomes and mitochondria
3-O-methylmannose polysaccharide
-
-
-
4-Pentenoate
-
reduced activity in microsomes
5,5'-dithiobis(2-nitrobenzoate)
-
-
6-O-methylglucose polysaccharide
-
-
-
Acetyl salicylate
-
reduced activity in microsomes
AMP
-
acetyl-CoA as substrate
beta-hydroxybutyrate
-
moderately inhibits the microsomal enzyme activity
bis-(4-nitrophenyl) phosphate
-
-
Co2+
-
slightly inhibits the mitochondrial enzyme
CoA
intraperoxisomal regulatory role
CoA-S-S-CoA
-
competitive to acetyl-CoA; i.e. oxidized CoA, additive with NADH, kinetics
D-carnitine
-
inhibits at concentrations over 6 mM
diisopropylfluorophosphate
dodecanoyl-CoA
-
substrate inhibition
DTNB
Q8GYW7
above 0.3 mM; above 0.3 mM
EDTA
-
inhibits the activity of the mitochondrial enzyme at concentrations of 0.5 mM
FAD
-
slightly inhibits the microsomal enzyme
FMN
-
inhibits the mitochondrial-matrix enzyme activity
fumarate
-
inhibits the mitochondrial-matrix enzyme activity
GTP
-
acetyl-CoA as substrate
hexadecanoyl-CoA
-
substrate inhibition
Ibuprofen
-
reduced activity in microsomes and mitochondria
L-carnitine
-
inhibits at concentrations over 6 mM
lysophosphatidic acid
-
-
lysophosphatidylethanolamine
-
weakly inhibitory
lysophosphatidylserine
-
weakly inhibitory
methyl methanethiosulfonate
-
slight inhibition
methylene blue
-
photooxidation
myristoyl-CoA
-
substrate inhibition, in vivo 28fold increased substrate concentration at 20°C leads to reduced enzyme activity
NAD+
-
inhibits the mitochondrial-matrix enzyme
NGDA
-
isozymes CTE-I and MTE-I
nicotinic acid
-
inhibits the mitochondrial-matrix enzyme activity
nordihydroguaiaretic acid
-
inhibition of acyl-CoA thioesterase and mitochondrial arachidonic acid-related thioesterase
O,O-Diethyl-O-(2,4,5-trichlorophenyl)-phosphate
-
-
O,O-Diethyl-O-(3,5,6-trichloro-2-pyridyl)-phosphate
-
-
O,O-diethyl-O-(3,5,6-trichloro-2-pyridyl)-phosphorothionate
-
i.e. Chloropyrifos
O,O-Dimethyl-O-(2,4,5-trichloro-1-phenyl)-phosphate
-
-
O,O-Dimethyl-O-(3,5,6-trichloro-2-pyridyl)-phosphate
-
i.e. Fospirate
octylglucoside
-
50% inhibition at 0.3%
p-chloromercuribenzoic acid
palmitic acid
-
1 mM inhibits by 30%
Pb2+
-
slightly inhibits the mitochondrial enzyme
tetradecanoyl-CoA
-
substrate inhibition
unsaturated fatty acids
-
-
-
Valproate
-
reduced activity in microsomes and mitochondria
2,4-dinitrofluorobenzene
-
inhibits very slowly
2,4-dinitrofluorobenzene
-
-
acetyl-CoA
-
-
acyl-CoA
Q8GYW7
e.g. lauroyl-CoA, at 0.005 mM, can be overcome by addition of bovine serum albumin or alpha-casein
acyl-CoA
substrate inhibition at concentrations higher than 0.005-0.01 mM of acyl-CoA longer than C10, BSA protects
ADP
-
inhibits the mitochondrial-matrix enzyme
ATP
-
inhibits ACH1 but not ACH2
ATP
-
inhibits the mitochondrial-matrix enzyme
ATP
-
competitive to acetyl-CoA
bovine serum albumin
-
-
-
bovine serum albumin
-
octadecanoyl-CoA as substrate, stimulates with C-6 to C-12 CoA as substrates
-
bovine serum albumin
-
-
-
bovine serum albumin
-
-
-
bovine serum albumin
-
a high amount inhibits the hydrolase
-
bovine serum albumin
-
a high amount inhibits the hydrolase
-
C75
-
binds the thioesterase domain in a similar orientation to that of palmitate, with its hydrophobic group buried inside the distal pocket and hydrophilic group interacting with the catalytic triad
C75
-
docking studies. C75 binds the thioestrase domain in a similar orientation to that of palmitate, with its hydrophobic group buried inside the distal pocket and hydrophilic group interacting with the catalytic triad
Ca2+
-
weakly inhibitory
Ca2+
-
inhibits ACH1, but ACH 2 just at higher concentrations
Ca2+
-
50% inhibition at 1.6 mM
Ca2+
-
inhibits the microsomal enzyme
Ca2+
-
10 mM inhibits the enzyme by 30-35%
Clofibrate
-
-
Clofibrate
-
reduced activity of the mitochondrial enzyme
CoASH
Q8GYW7
feedback inhibition of recombinant enzyme at concentrations above 0.1 mM
CoASH
-
product inhibition, acetyl-CoA as substrate, kinetics
Cu2+
-
-
diethyldicarbonate
-
95% inhibition at 2 mM
diethyldicarbonate
hydroxylamine reverses
diethyldicarbonate
-
hydroxylamine reverses
diethyldicarbonate
-
inactivation
diisopropylfluorophosphate
-
94% inhibition at 5 mM, maximal inhibition
diisopropylfluorophosphate
-
complete inhibition
diisopropylfluorophosphate
-
0.01 mM inhibits
diisopropylfluorophosphate
-
no inhibition
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
at 0.01 mM inhibition of 95% after 40 min.
diisopropylfluorophosphate
-
1 mM DFP at 40 min at 25°C produces a 95% inhibition at palmityl thioesterase I
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
1 mM inhibits activity completely
diisopropylfluorophosphate
-
-
iodoacetamide
-
-
KCl
-
-
KCl
-
inhibits at high concentrations
KCl
-
inhibits the mitochondrial enzyme above 125 mM
L-palmitoyl carnitine
-
competitively inhibits at 0.02-04 mM
L-palmitoyl carnitine
-
competitive to acyl-CoA
lysophosphatidylcholine
-
strongly inhibitory
lysophosphatidylcholine
-
-
lysophosphatidylcholine
-
-
lysophosphatidylinositol
-
strong inhibition
lysophosphatidylinositol
-
-
Mg2+
-
weak inhibition
Mg2+
-
0.5 mM gives 40% inhibition
Mg2+
-
inhibits ACH1, but ACH2 just at higher concentrations
Mg2+
-
50% inhibition at 1.6 mM
Mg2+
-
inhibits the microsomal enzyme, at higher concentrations also the mitochondrial enzyme
Mg2+
-
10 mM inhibits the enzyme by 30-35%
Mn2+
-
weakly inhibitory
Mn2+
-
0.2 mM gives 60% inhibition
Mn2+
-
inhibits ACH1, but ACH2 just at higher concentrations
N-ethylmaleimide
-
0.001 mM gives 50% inhibition
NaCl
-
-
NaCl
-
inhibits at high concentrations
NADH
-
no inhibition
NADH
-
additive with oxidized CoA, noncompetitive
oleic acid
-
-
oleic acid
-
1 mM inhibits by 90%
orlistat
-
in the lowest-energy conformation, its central formylamino group is very close to the catalytic triad of the thioesterase domain. Its shorter chain is placed into the distal pocket where palmitate acyl chain binds and its longer chain extends into pocket 2
orlistat
-
docking studies, high binding affinity for the thioesterase domain
p-chloromercuribenzoic acid
-
-
p-chloromercuribenzoic acid
-
p-chloromercuribenzoic acid
-
-
p-hydroxymercuribenzoate
-
99% inhibition at 0.1 mM
p-hydroxymercuribenzoate
-
weak inhibition
p-hydroxymercuribenzoate
-
0.005 mM gives 50% inhibition
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
p-hydroxymercuribenzoate
-
-
PMSF
-
96% inhibition at 1 mM
PMSF
-
less effective than DFP, produces a 27% loss of activity under similar conditions
SDS
-
-
SDS
-
50% inhibition at 0.035%
sodium deoxycholate
-
-
sodium deoxycholate
-
50% inhibition at 0.04%
Triton X-100
-
-
Triton X-100
-
0.05-.0025% inhibits the activity
Triton X-100
-
50% inhibition at 0.01%
Zn2+
-
-
additional information
-
reversible substrate inhibition by long-chain acyl-CoAs at concentration 0.005 mM, reversibel by bovine serum albumin and alpha-casein
-
additional information
Q8GYW7
reversible substrate inhibition by long-chain acyl-CoAs at concentration 0.005 mM, reversibel by bovine serum albumin and alpha-casein
-
additional information
no inhibition by iodoacetate
-
additional information
-
no inhibition by iodoacetate
-
additional information
-
no inhibition by NEM
-
additional information
-
-
-
additional information
-
no inhibition by NEM, iodoacetamide, L-carnitine
-
additional information
-
no inhibition by EDTA, Mg2+, Fe2+, NAD+, NADP+, NADPH, glutamate, 2-oxoglutarate, pyruvate, alanine, asparagine, succinate; no inhibition by NEM
-
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(tetradecylsulfanyl)acetic acid
-
stimulates palmitoyl-CoA, tetradecylthioacetyl-CoA and tetradecylthiopropionyl-CoA hydrolase activities in cytosol, mitochondrion and peroxisome, overview
1-acyl-sn-glycero-3-phosphocholine
-
0.5 mM stimulates acylation 3-9fold
3-(tetradecylsulfanyl)propanoic acid
-
stimulates palmitoyl-CoA, tetradecylthioacetyl-CoA and tetradecylthiopropionyl-CoA hydrolase activities in cytosol, mitochondrion and peroxisome, overview
3-hydroxybutyrate
-
stimulates the mitochondrial-matrix enzyme activity
3-thiadicarboxylic acid
-
-
ADP
-
stimulates the microsomal activity
ATP
-
stimulates the microsomal activity
di(2-ethylhexyl)phthalate
EDTA
-
stimulates the activity of the mitochondrial enzyme above 2 mM
Elongation factor
-
chain elongation
-
ethyl p-chlorophenoxyisobutyrate
-
-
FAD
-
stimulates the activity of the mitochondrial-matrix enzyme up to 0.4 mM
fish oil
-
partially hydrogenated, hydrolase activity reaches maximum after administration of the dietary oil for 6.5 days
-
FMN
-
stimulates the microsomal activity
fumarate
-
stimulates the microsomal activity
hexadecanol
-
activation, only with acyl-CoA of more than C-8 as substrates
isopropyl thiogalactoside
-
isoproterenol
-
stimulates enzyme expression, can be blocked by specific beta-adrenoreceptor antagonists, e.g. actinomycin D
L-carnitine
-
activates at low concentrations
linoleic acid
-
both conjugated and gamma-linoleic acid, increase activity
lysophosphatidylcholine
-
-
lysophosphatidylethanolamine
-
-
malate
-
stimulates the mitochondrial-matrix enzyme activity
NAD+
-
stimulates the microsomal activity
oleate
induces enzyme expression in peroxisomes
peroxisome proliferator WY-14,643
induction of enzyme expression, dependent on peroxisome proliferator-activated receptor alpha
peroxisome proliferator-activated receptor alpha
-
induction of the isozymes in the liver
-
Phenobarbital
-
2-3fold enhancement of activity
phosphatidylethanolamine
-
-
polyunsaturated fatty acids
-
diet rich in polyunsaturated fatty acids increase in enzyme activity in Walker 256 tumour along with an increase in peroxisome number in the tissue
-
succinate
-
stimulates the mitochondrial-matrix enzyme activity
Tetradecanol
-
activation, only with acyl-CoA of more than C-8 as substrates
tetradecylthioacetic acid
-
-
ACTH
-
-
-
ACTH
-
stimulation of mitochondrial enzyme activity
-
bovine serum albumin
-
activation
-
bovine serum albumin
-
effect of stimulation increases as chain-length increases up to C-12 and decreases progressively as chain-length increases beyond C-12, inhibitory with octadecanoyl-CoA as substrate
-
bovine serum albumin
-
-
-
bovine serum albumin
-
-
-
bovine serum albumin
-
a small amount activates the hydrolase
-
bovine serum albumin
-
-
-
bovine serum albumin
-
activation
-
bovine serum albumin
-
only with long-chain acyl-CoA as substrate
-
Clofibrate
-
-
Clofibrate
-
peroxisome proliferator
Clofibrate
-
isozymes CTE-I and MTE-I are induced, induction is completely dependent on PPARalpha
Clofibrate
-
induction of all 4 isozymes, mediated through a strictly peroxisome proliferator-activated receptor alpha, PPARalpha, function in gene regulation
Clofibrate
-
hypolipidemic drug
Clofibrate
-
2-3fold enhancement of activity
Clofibrate
2fold induction in the kidney, 130fold induction in the liver
di(2-ethylhexyl)phthalate
-
peroxisome proliferator
di(2-ethylhexyl)phthalate
-
induction of enzyme expression
di(2-ethylhexyl)phthalate
-
-
di(2-ethylhexyl)phthalate
-
di(2-ethylhexyl)phthalate
-
-
di(2-ethylhexyl)phthalate
-
di(2-ethylhexyl)phthalate
-
stimulates
di(2-ethylhexyl)phthalate
strong induction in liver, moderately in kidney
di(2-ethylhexyl)phthalate
-
a plastisizer
di(2-ethylhexyl)phthalate
induction in liver, slightly in kidney
di(2-ethylhexyl)phthalate
-
induces the mitochondrial enzyme by 10fold
dithiothreitol
-
-
dithiothreitol
-
stimulation of the microsomal enzyme
monoethylhexylphthalate
-
-
monoethylhexylphthalate
-
-
monoethylhexylphthalate
-
-
nicotinic acid
-
-
nicotinic acid
-
stimulates the microsomal activity
PPARalpha
-
internal receptor protein essential for effect of stimulating compounds
-
PPARalpha
internal receptor protein essential for effect of stimulating compounds
-
PPARalpha
-
gene expression inducing and regulatory role, mediates the stimulation by clofibrate
-
PPARalpha
-
i.e. peroxisome proliferator-activated receptor alpha
-
PPARalpha
i.e. peroxisome proliferator-activated receptor alpha
-
tiadenol
-
-
tiadenol
-
produces a 7-9fold increase of the total activity
Triton X-100
-
slightly stimulates at low concentrations
Triton X-100
-
activation, 0.005%, dodecanoyl-CoA as substrate
Triton X-100
-
prevents inhibition together with serum albumin
Triton X-100
-
0.005% slightly stimulates the activity
additional information
-
no stimulation of activity by docosahexaenoic and eisosapentaenoic acids
-
additional information
fasting induces enzyme expression, dependent on peroxisome proliferator-activated receptor alpha
-
additional information
-
fasting induces enzyme expression, dependent on peroxisome proliferator-activated receptor alpha
-
additional information
-
fat fasting rapidly induces all isozymes, rapidly reversible
-
additional information
-
cold acclimation induces enzyme activity
-
additional information
-
no stimulation by tetradecylthiopropionate
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Adenocarcinoma
ACOT1 expression is associated with poor prognosis in gastric adenocarcinoma.
Adenocarcinoma
Medium chain fatty acid synthesis in rodent mammary adenocarcinomas in vitro.
Alzheimer Disease
Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases.
Atherosclerosis
Inflammatory stimuli induce acyl-CoA thioesterase 7 and remodeling of phospholipids containing unsaturated long (?C20)-acyl chains in macrophages.
Breast Neoplasms
Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKC?-p53-p21 signaling pathway.
Breast Neoplasms
An Inhibitor of Fatty Acid Synthase Thioesterase Domain with Improved Cytotoxicity against Breast Cancer Cells and Stability in Plasma.
Breast Neoplasms
Evaluation of thioesterase II as a serum marker for rat mammary cancer.
Carcinogenesis
The NIEHS Predictive-Toxicology Evaluation Project.
Carcinoma
Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKC?-p53-p21 signaling pathway.
Carcinoma
Thioesterase II, a new marker enzyme for human cells of breast epithelial origin.
Carcinoma, Hepatocellular
Fenofibrate induces human hepatoma Hep3B cells apoptosis and necroptosis through inhibition of thioesterase domain of fatty acid synthase.
Cholera
Response of end bud cells from immature rat mammary gland to hormones when cultured in collagen gel.
Colonic Neoplasms
Human and mouse colon cancer utilizes CD95 signaling for local growth and metastatic spread to liver.
Coma
Effect of inulin on efficient production and regulatory biosynthesis of bacillomycin D in Bacillus subtilis fmbJ.
Coma
Mutagenesis separates ATPase and thioesterase activities of the peroxisomal ABC transporter, Comatose.
Communicable Diseases
Identification, characterization, and inhibition of Plasmodium falciparum beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ).
Deficiency Diseases
Neuroprotection and lifespan extension in Ppt1(-/-) mice by NtBuHA: therapeutic implications for INCL.
Dehydration
Cis-Double Bond Formation by Thioesterase and Transfer by Ketosynthase in FR901464 Biosynthesis.
Dehydration
Discovery of a Mosaic-Like Biosynthetic Assembly Line with a Decarboxylative Off-Loading Mechanism through a Combination of Genome Mining and Imaging.
Diabetes Mellitus, Type 2
Disallowance of Acot7 in ?-cells is required for normal glucose tolerance and insulin secretion.
Diabetes Mellitus, Type 2
The Thioesterase ACOT1 as a Regulator of Lipid Metabolism in Type 2 Diabetes Detected in a Multi-Omics Study of Human Liver.
Fatty Liver
Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development.
Fatty Liver
Hepatoprotective and anti-inflammatory effects of a standardized pomegranate (Punica granatum) fruit extract in high fat diet-induced obese C57BL/6 mice.
Fatty Liver
Metabolic and Tissue-Specific Regulation of Acyl-CoA Metabolism.
Glucose Intolerance
Loss of ACOT7 potentiates seizures and metabolic dysfunction.
Hepatomegaly
The hypolipidemic peroxisome-proliferating drug, bis(carboxymethylthio)-1.10 decane, a dicarboxylic metabolite of tiadenol, is activated to an acylcoenzyme A thioester.
Huntington Disease
Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases.
Hypertriglyceridemia
Reversal of obesity-induced hypertriglyceridemia by (R)-?-lipoic acid in ZDF (fa/fa) rats.
Infections
Identification of Low Molecular Weight Proteins and Peptides from Schistosoma mekongi Worm, Egg and Infected Mouse Sera.
Influenza, Human
Unravelling the thioesterases responsible for propionate formation in engineered Pseudomonas putida KT2440.
Influenza, Human
YesT: a new rhamnogalacturonan acetyl esterase from Bacillus subtilis.
Insulin Resistance
AICAR Protects against High Palmitate/High Insulin-Induced Intramyocellular Lipid Accumulation and Insulin Resistance in HL-1 Cardiac Cells by Inducing PPAR-Target Gene Expression.
Insulin Resistance
Metabolic and Tissue-Specific Regulation of Acyl-CoA Metabolism.
Insulin Resistance
Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance.
Intellectual Disability
Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases.
Leukemia, Myeloid, Acute
Expression level of ACOT7 influences the prognosis in acute myeloid leukemia patients.
Lipidoses
The long-chain acyl-CoA hydrolase activity in the heart of rat fed on rape-seed oil.
Liver Neoplasms, Experimental
Induction of peroxisomal beta-oxidation in 7800 C1 Morris hepatoma cells in steady state by fatty acids and fatty acid analogues.
Liver Neoplasms, Experimental
Synergistic actions of tetradecylthioacetic acid (TTA) and dexamethasone on induction of the peroxisomal beta-oxidation and on growth inhibition of Morris hepatoma cells. Both effects are counteracted by insulin.
Lung Neoplasms
Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKC?-p53-p21 signaling pathway.
Lysosomal Storage Diseases
Lysosomal storage diseases: Thioesterase mimetic reduces toxicity.
Malaria
Fatty Acid synthesis as a target for antimalarial drug discovery.
Malaria
Identification, characterization, and inhibition of Plasmodium falciparum beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ).
Melanoma
Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells.
Melanoma
Wnt5a signaling induced phosphorylation increases APT1 activity and promotes melanoma metastatic behavior.
Myoclonus
A girl with infantile neuronal ceroid lipofuscinosis caused by novel PPT1 mutation and paternal uniparental isodisomy of chromosome 1.
Neoplasms
A functional variant in the transcriptional regulatory region of gene LOC344967 cosegregates with disease phenotype in familial nasopharyngeal carcinoma.
Neoplasms
ACTH regulation of mitochondrial acyl-CoA thioesterase activity in Y1 adrenocortical tumour cells.
Neoplasms
Dose and Effect Thresholds for Early Key Events in a PPAR?-Mediated Mode of Action.
Neoplasms
Evaluation of thioesterase II as a serum marker for rat mammary cancer.
Neoplasms
Evidence for the involvement of polyunsaturated fatty acids in the regulation of long-chain acyl CoA thioesterases and peroxisome proliferation in rat carcinosarcoma.
Neoplasms
Human and mouse colon cancer utilizes CD95 signaling for local growth and metastatic spread to liver.
Neoplasms
Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain.
Neoplasms
Interaction between ACOT7 and LncRNA NMRAL2P via Methylation Regulates Gastric Cancer Progression.
Neoplasms
Metabolic Shifts Induced by Fatty Acid Synthase Inhibitor Orlistat in Non-small Cell Lung Carcinoma Cells Provide Novel Pharmacodynamic Biomarkers for Positron Emission Tomography and Magnetic Resonance Spectroscopy.
Neoplasms
Molecular docking study of the interactions between the thioesterase domain of human fatty acid synthase and its ligands.
Neoplasms
Novel antagonists of the thioesterase domain of human fatty acid synthase.
Neoplasms
Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity.
Neoplasms
RAS Subcellular Localization Inversely Regulates Thyroid Tumor Growth and Dissemination.
Neoplasms
Regulation of conidiation and antagonistic properties of the soil-borne plant beneficial fungus Trichoderma virens by a novel proline-, glycine-, tyrosine-rich protein and a GPI-anchored cell wall protein.
Neoplasms
The mammalian START domain protein family in lipid transport in health and disease.
Neoplasms
The tumour promoter 12-O-tetradecanoylphorbol-13-acetate increases the activities of some peroxisome-associated enzymes in in vitro cell culture.
Neoplasms
Thioesterase II, a new marker enzyme for human cells of breast epithelial origin.
Neuroblastoma
Novel Interactive Partners of Neuroligin 3: New Aspects for Pathogenesis of Autism.
Neuroinflammatory Diseases
In a mouse model of INCL reduced S-palmitoylation of cytosolic thioesterase APT1 contributes to microglia proliferation and neuroinflammation.
Neuronal Ceroid-Lipofuscinoses
A girl with infantile neuronal ceroid lipofuscinosis caused by novel PPT1 mutation and paternal uniparental isodisomy of chromosome 1.
Neuronal Ceroid-Lipofuscinoses
Atypical late infantile and juvenile forms of neuronal ceroid lipofuscinosis and their diagnostic difficulties.
Neuronal Ceroid-Lipofuscinoses
Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis.
Neuronal Ceroid-Lipofuscinoses
Disruption of PPT2 in mice causes an unusual lysosomal storage disorder with neurovisceral features.
Neuronal Ceroid-Lipofuscinoses
Palmitoyl:protein thioesterase (PPT1) inhibitors can act as pharmacological chaperones in infantile Batten disease.
Neuronal Ceroid-Lipofuscinoses
pdf1, a palmitoyl protein thioesterase 1 Ortholog in Schizosaccharomyces pombe: a yeast model of infantile Batten disease.
Neuronal Ceroid-Lipofuscinoses
Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases.
Obesity
A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.
Obesity
A high fat diet increases mitochondrial fatty acid oxidation and uncoupling to decrease efficiency in rat heart.
Obesity
Mechanism of Orlistat Hydrolysis by the Thioesterase of Human Fatty Acid Synthase.
Obesity
Metabolic and Tissue-Specific Regulation of Acyl-CoA Metabolism.
Obesity
Molecular docking study of the interactions between the thioesterase domain of human fatty acid synthase and its ligands.
Obesity
Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance.
palmitoyl-coa hydrolase deficiency
Inflammatory stimuli induce acyl-CoA thioesterase 7 and remodeling of phospholipids containing unsaturated long (?C20)-acyl chains in macrophages.
palmitoyl-coa hydrolase deficiency
Neuroprotection and lifespan extension in Ppt1(-/-) mice by NtBuHA: therapeutic implications for INCL.
palmitoyl-coa hydrolase deficiency
[Effect of short-chain thioesterase deficiency on P(3HB-co-LA) biosynthesis in Escherichia coli].
Pancreatic Neoplasms
A Transcriptome-Wide Association Study Identifies Candidate Susceptibility Genes for Pancreatic Cancer Risk.
Peripheral Arterial Disease
Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease.
Scabies
YesT: a new rhamnogalacturonan acetyl esterase from Bacillus subtilis.
Seizures
Loss of ACOT7 potentiates seizures and metabolic dysfunction.
Sepsis
Cardiomyocyte specific expression of Acyl-coA thioesterase 1 attenuates sepsis induced cardiac dysfunction and mortality.
Starvation
Inhibition of fatty acid synthesis in Escherichia coli in the absence of phospholipid synthesis and release of inhibition by thioesterase action.
Stomach Neoplasms
ACOT1 expression is associated with poor prognosis in gastric adenocarcinoma.
Stomach Neoplasms
Interaction between ACOT7 and LncRNA NMRAL2P via Methylation Regulates Gastric Cancer Progression.
Stroke
Genome-Wide Association Study of White Blood Cell Counts in Patients With Ischemic Stroke.
Tuberculosis
Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules.
Tuberculosis
Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Tuberculosis
Insights into the Substrate Specificity of a Thioesterase Rv0098 of Mycobacterium Tuberculosis through X-ray Crystallographic and Molecular Dynamics Studies.
Tuberculosis
Lipid biosynthesis as a target for antibacterial agents.
Tularemia
Functional expression of Francisella tularensis FabH and FabI, potential antibacterial targets.
Vision Disorders
A girl with infantile neuronal ceroid lipofuscinosis caused by novel PPT1 mutation and paternal uniparental isodisomy of chromosome 1.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.048
acetoacetyl-CoA
-
-
0.0004 - 0.0092
Arachidonoyl-CoA
0.0042
arachidoyl-CoA
pH 7.4
0.013
butyryl-CoA
-
pH 7.8, 22°C
0.0088
chenodeoxycholoyl-CoA
pH 7.4
0.0146
choloyl-CoA
pH 7.4
0.08735
crotonyl-CoA
pH 7.5
0.0027 - 0.067
decanoyl-CoA
0.0018 - 0.325
dodecanoyl-CoA
0.0004 - 0.0048
eicosanoyl-CoA
0.00013 - 0.006
fatty-acyl-CoA thioester
0.0000158 - 0.08
hexadecanoyl-CoA
0.0055 - 0.077
hexanoyl-CoA
0.03852 - 0.185
lauroyl-CoA
0.00786
linolenoyl-CoA
-
-
0.0014 - 0.0023
linoleoyl-CoA
0.0046
myristoleoyl-CoA
-
-
0.0033 - 0.018
myristoyl-CoA
0.043 - 0.174
N-carbobenzoxy-L-tyrosine p-nitrophenyl ester
0.0004 - 0.034
octadecanoyl-CoA
0.007 - 0.118
octanoyl-CoA
0.0014 - 0.0088
oleoyl-CoA
0.61 - 1.88
p-nitrophenyl butyrate
0.0014 - 0.058
palmitoleoyl-CoA
0.0033 - 0.023
palmitoyl-CoA
0.024 - 0.1028
stearoyl-CoA
0.0016 - 0.024
tetradecanoyl-CoA
0.0063
trihydroxycoprostanoyl-CoA
pH 7.4
0.00084
vaccenoyl-CoA
-
-
additional information
additional information
-
0.0004
Arachidonoyl-CoA
-
-
0.002
Arachidonoyl-CoA
-
isozyme MTE-I, pH 7.4, 37°C
0.0041
Arachidonoyl-CoA
-
isozyme CTE-I, pH 7.4, 37°C
0.0046
Arachidonoyl-CoA
-
pH 7.5, 37°C
0.0067
Arachidonoyl-CoA
pH 7.4
0.0092
Arachidonoyl-CoA
pH 7.4, 30°C
0.077
CoA
-
-
0.0027
decanoyl-CoA
-
pH 7.8, 22°C
0.027
decanoyl-CoA
-
pH 7.0, 30°C
0.067
decanoyl-CoA
-
pH 8.0, 25°C
0.067
decanoyl-CoA
-
pH 7.4, 25°C
0.0018
dodecanoyl-CoA
-
pH 7.8, 22°C
0.0038
dodecanoyl-CoA
-
pH 7.5, 37°C
0.0076
dodecanoyl-CoA
pH 7.4, 30°C
0.0077
dodecanoyl-CoA
-
-
0.014
dodecanoyl-CoA
-
pH 7.0, 30°C
0.0178
dodecanoyl-CoA
Q8GYW7
-
0.018
dodecanoyl-CoA
Q8GYW7
pH 8.0
0.01913
dodecanoyl-CoA
pH 7.5
0.04468
dodecanoyl-CoA
-
-
0.0004
eicosanoyl-CoA
-
-
0.00013 - 0.006
fatty-acyl-CoA thioester
-
-
0.00013 - 0.006
fatty-acyl-CoA thioester
-
-
0.00013 - 0.006
fatty-acyl-CoA thioester
-
-
0.0000158
hexadecanoyl-CoA
-
-
0.0001
hexadecanoyl-CoA
-
-
0.0005
hexadecanoyl-CoA
-
pH 7.8, 22°C
0.0008
hexadecanoyl-CoA
-
-
0.0014
hexadecanoyl-CoA
-
-
0.0017
hexadecanoyl-CoA
pH 7.4
0.00186
hexadecanoyl-CoA
-
-
0.002
hexadecanoyl-CoA
-
-
0.0036
hexadecanoyl-CoA
-
0.005
hexadecanoyl-CoA
-
micellar
0.0057
hexadecanoyl-CoA
-
-
0.0058
hexadecanoyl-CoA
-
pH 7.5, 37°C
0.0062
hexadecanoyl-CoA
-
-
0.0064
hexadecanoyl-CoA
pH 7.4, 30°C
0.008
hexadecanoyl-CoA
-
-
0.009
hexadecanoyl-CoA
-
-
0.01
hexadecanoyl-CoA
recombinant enzyme
0.012
hexadecanoyl-CoA
-
-
0.015
hexadecanoyl-CoA
-
-
0.017
hexadecanoyl-CoA
-
-
0.017
hexadecanoyl-CoA
-
pH 7.0, 30°C
0.023
hexadecanoyl-CoA
-
pH 7.4, 25°C
0.045
hexadecanoyl-CoA
the induced E. coli enzyme
0.047
hexadecanoyl-CoA
-
-
0.047
hexadecanoyl-CoA
-
for the microsomal enzyme
0.06
hexadecanoyl-CoA
brain ACT
0.07 - 0.08
hexadecanoyl-CoA
-
-
0.0055
hexanoyl-CoA
-
pH 7.8, 22°C
0.06318
hexanoyl-CoA
pH 7.5
0.077
hexanoyl-CoA
-
pH 7.0, 30°C
0.03852
lauroyl-CoA
pH 7.5
0.059
lauroyl-CoA
37°C, pH 7, mutant enzyme D154A
0.073
lauroyl-CoA
mutant enzyme P110A/L109P
0.075
lauroyl-CoA
37°C, pH 7, mutant enzyme G44A
0.085
lauroyl-CoA
37°C, pH 7, mutant enzyme N73A
0.113
lauroyl-CoA
mutant enzyme P110A
0.127
lauroyl-CoA
37°C, pH 7, mutant enzyme, S10A
0.146
lauroyl-CoA
native enzyme
0.146
lauroyl-CoA
37°C, pH 7, wild-type enzyme
0.185
lauroyl-CoA
mutant enzyme L109P
0.0014
linoleoyl-CoA
-
-
0.0023
linoleoyl-CoA
pH 7.4
0.0033
myristoyl-CoA
at pH 7.6 and 37°C
0.018
myristoyl-CoA
-
pH 8.0, 25°C
0.043
N-carbobenzoxy-L-tyrosine p-nitrophenyl ester
37°C, pH 7, mutant enzyme D154A
0.044
N-carbobenzoxy-L-tyrosine p-nitrophenyl ester
37°C, pH 7, mutant enzyme N73A
0.06
N-carbobenzoxy-L-tyrosine p-nitrophenyl ester
37°C, pH 7, mutant enzyme G44A
0.061
N-carbobenzoxy-L-tyrosine p-nitrophenyl ester
37°C, pH 7, mutant enzyme, S10A
0.174
N-carbobenzoxy-L-tyrosine p-nitrophenyl ester
37°C, pH 7, wild-type enzyme
0.0004
octadecanoyl-CoA
-
pH 7.8, 22°C
0.0024
octadecanoyl-CoA
-
0.0028
octadecanoyl-CoA
-
0.024
octadecanoyl-CoA
-
pH 7.4, 25°C
0.034
octadecanoyl-CoA
-
pH 7.0, 30°C
0.007
octanoyl-CoA
-
pH 7.8, 22°C
0.014
octanoyl-CoA
pH 7.4, 30°C
0.043
octanoyl-CoA
-
pH 7.0, 30°C
0.118
octanoyl-CoA
-
pH 8.0, 25°C
0.118
octanoyl-CoA
-
pH 7.4, 25°C
0.0014
oleoyl-CoA
-
-
0.0058
oleoyl-CoA
Q8GYW7
-
0.0088
oleoyl-CoA
pH 7.4, 30°C
0.61
p-nitrophenyl butyrate
37°C, pH 7, mutant enzyme H157A
0.87
p-nitrophenyl butyrate
37°C, pH 7, wild-type enzyme
1.1
p-nitrophenyl butyrate
37°C, pH 7, mutant enzyme G44A
1.55
p-nitrophenyl butyrate
37°C, pH 7, mutant enzyme S10A
1.66
p-nitrophenyl butyrate
37°C, pH 7, mutant enzyme N73A
1.88
p-nitrophenyl butyrate
37°C, pH 7, mutant enzyme D154A
0.0014
palmitoleoyl-CoA
pH 7.4
0.0024
palmitoleoyl-CoA
-
0.0045
palmitoleoyl-CoA
-
0.0058
palmitoleoyl-CoA
Q8GYW7
pH 8.0
0.058
palmitoleoyl-CoA
-
pH 8.0, 25°C
0.058
palmitoleoyl-CoA
-
pH 7.4, 25°C
0.0033
palmitoyl-CoA
at pH 7.6 and 37°C
0.01187
palmitoyl-CoA
pH 7.5
0.023
palmitoyl-CoA
-
pH 8.0, 25°C
0.024
stearoyl-CoA
-
pH 8.0, 25°C
0.1028
stearoyl-CoA
pH 7.5
0.0016
tetradecanoyl-CoA
-
0.0017
tetradecanoyl-CoA
-
pH 7.8, 22°C
0.0025
tetradecanoyl-CoA
pH 7.4
0.0028
tetradecanoyl-CoA
-
0.0066
tetradecanoyl-CoA
-
-
0.00867
tetradecanoyl-CoA
-
-
0.018
tetradecanoyl-CoA
-
pH 7.4, 25°C
0.024
tetradecanoyl-CoA
-
pH 7.0, 30°C
additional information
additional information
-
-
additional information
additional information
-
-
-
additional information
additional information
-
kinetics
-
additional information
additional information
Q8GYW7
kinetics
-
additional information
additional information
-
effect of pH on kinetic data
-
additional information
additional information
-
Km at different temperatures
-
additional information
additional information
diverse substrates, kinetics
-
additional information
additional information
-
diverse substrates, kinetics
-
additional information
additional information
-
Km for myristoyl-CoA is 59fold higher at 20°C compared to 5°C
-
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0.0078
crotonyl-CoA
pH 7.5
0.01
dodecanoyl-CoA
pH 7.5
0.012
hexanoyl-CoA
pH 7.5
0.015 - 10.13
lauroyl-CoA
0.02 - 88.99
N-carbobenzoxy-L-tyrosine p-nitrophenyl ester
0.0093 - 15.29
p-nitrophenyl butyrate
0.037 - 153
palmitoyl-CoA
additional information
N-carbobenzoxy-L-tyrosine p-nitrophenyl ester
136
decanoyl-CoA
-
pH 7.4, 25°C
136
decanoyl-CoA
-
pH 8.0, 25°C
0.015
lauroyl-CoA
pH 7.5
0.052 - 2.1
lauroyl-CoA
native enzyme
0.052 - 2.1
lauroyl-CoA
37°C, pH 7, wild-type enzyme
0.057
lauroyl-CoA
37°C, pH 7, mutant enzyme, S10A
0.45
lauroyl-CoA
37°C, pH 7, mutant enzyme D154A
0.57
lauroyl-CoA
mutant enzyme L109P
0.77
lauroyl-CoA
37°C, pH 7, mutant enzyme G44A
0.84
lauroyl-CoA
mutant enzyme P110A/L109P
1.14
lauroyl-CoA
37°C, pH 7, mutant enzyme N73A
3.8
lauroyl-CoA
mutant enzyme P110A
10.13
lauroyl-CoA
native enzyme
10.13
lauroyl-CoA
37°C, pH 7, wild-type enzyme
183
myristoyl-CoA
-
pH 7.4, 25°C
183
myristoyl-CoA
-
pH 8.0, 25°C
0.02
N-carbobenzoxy-L-tyrosine p-nitrophenyl ester
37°C, pH 7, mutant enzyme, S10A
0.031 - 0.51
N-carbobenzoxy-L-tyrosine p-nitrophenyl ester
37°C, pH 7, mutant enzyme G44A
6.44
N-carbobenzoxy-L-tyrosine p-nitrophenyl ester
37°C, pH 7, mutant enzyme D154A
7.71
N-carbobenzoxy-L-tyrosine p-nitrophenyl ester
37°C, pH 7, mutant enzyme G44A
7.81
N-carbobenzoxy-L-tyrosine p-nitrophenyl ester
37°C, pH 7, mutant enzyme N73A
23.8
N-carbobenzoxy-L-tyrosine p-nitrophenyl ester
37°C, pH 7, wild-type enzyme
88.99
N-carbobenzoxy-L-tyrosine p-nitrophenyl ester
37°C, pH 7, wild-type enzyme
159
octanoyl-CoA
-
pH 7.4, 25°C
159
octanoyl-CoA
-
pH 8.0, 25°C
0.0093
p-nitrophenyl butyrate
37°C, pH 7, mutant enzyme H157A
0.16
p-nitrophenyl butyrate
37°C, pH 7, mutant enzyme S10A
0.41
p-nitrophenyl butyrate
37°C, pH 7, mutant enzyme N73A
0.55
p-nitrophenyl butyrate
37°C, pH 7, wild-type enzyme
3.16
p-nitrophenyl butyrate
37°C, pH 7, mutant enzyme G44A
5.98
p-nitrophenyl butyrate
37°C, pH 7, mutant enzyme D154A
11.99
p-nitrophenyl butyrate
37°C, pH 7, mutant enzyme N73A
15.29
p-nitrophenyl butyrate
37°C, pH 7, wild-type enzyme
106
palmitoleoyl-CoA
-
pH 7.4, 25°C
106
palmitoleoyl-CoA
-
pH 8.0, 25°C
0.037
palmitoyl-CoA
pH 7.5
153
palmitoyl-CoA
-
pH 7.4, 25°C
153
palmitoyl-CoA
-
pH 8.0, 25°C
0.019
stearoyl-CoA
pH 7.5
121
stearoyl-CoA
-
pH 7.4, 25°C
121
stearoyl-CoA
-
pH 8.0, 25°C
additional information
N-carbobenzoxy-L-tyrosine p-nitrophenyl ester
37°C, pH 7, mutant enzyme D154A
additional information
N-carbobenzoxy-L-tyrosine p-nitrophenyl ester
-
37°C, pH 7, mutant enzyme D154A
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0.000048 - 0.000058
-
Walker 256 tumour, normal chow, substrate stearoyl-CoA
0.000072
-
Walker 256 tumour, normal chow, substrate palmitoleoyl-CoA
0.000095 - 0.000111
-
Walker 256 tumour, normal chow, substrate oleoyl-CoA
0.000133 - 0.000142
-
Walker 256 tumour, normal chow, substrate palmitoyl-CoA
0.003 - 0.009
-
partially purified enzyme, medium- and long chain fatty acid hydrolase activity
0.039
-
post-nuclear fraction, substrate tetradecylthiopropionyl-CoA
0.044
-
post-nuclear fraction, substrate palmitoyl-CoA
0.057
-
post-nuclear fraction, substrate tetradecylthioacetyl-CoA
0.086
-
CHO cells, substrate palmitoyl-CoA
0.15
-
mitochondrial enzyme form, substrate arachidonoyl-CoA
0.16
-
kidney cortex microsomes, substrate palmitoyl-CoA
0.21
-
kidney cortex microsomes, substrate arachidonoyl-CoA
0.28
-
kidney cortex cytosol, substrate palmitoyl-CoA
0.35
-
kidney medulla microsomes, substrate arachidonoyl-CoA
0.46
-
kidney medulla cytosol, substrate palmitoyl-CoA
0.47
-
kidney cortex cytosol, substrate arachidonoyl-CoA
0.5
recombinant enzyme in CHO cells, substrate palmitoyl-CoA
0.54
-
kidney medulla cytosol, substrate arachidonoyl-CoA
1478
-
purified enzyme, substrate palmitoyl-CoA
198
purified native enzyme, substrate palmitoyl-CoA
2.7
-
partially purified enzyme
41.6
-
purified enzyme, decanoyl-CoA as substrate
45.4
-
partially purified enzyme
9.5
-
purified enzyme, lauroyl-CoA as substrate
93.8
purified recombinant enzyme
0.26
-
kidney medulla microsomes, substrate palmitoyl-CoA
108
-
purified enzyme
108
-
purified enzyme, substrate myristoyl-CoA
21
Q8GYW7
purified recombinant enzyme, substrate palmitoleoyl-CoA
21
Q8GYW7
activity with palmitoleoyl-CoA
additional information
-
-
additional information
-
-
additional information
-
activities in different subcellular fractions with different substrates after induction with 3-thia fatty acids, overview
additional information
-
effects of diet conditions on enzyme activity
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-
brown and white, weak expression of Acot7 in male mice
brenda
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-
brenda
-
-
brenda
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-
brenda
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-
brenda
-
-
brenda
-
-
brenda
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-
brenda
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enzyme is induced during embryogenesis in association with neuronal differentiation
brenda
-
-
brenda
Q8GYW7
-
brenda
-
brenda
weak expression of MTE-I, expression of CTE-I, PTE-Ib, and PTE-Ia
brenda
brain-specific isozyme
brenda
-
-
brenda
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cell line derived from Walker 256 tumour
brenda
up-regulated by lipopolysaccharide and that overexpression of Acot7 in a macrophage cell line alters the production of prostaglandins D2 and E2
brenda
-
-
brenda
-
-
brenda
-
-
brenda
weak expression
brenda
-
-
brenda
Q8GYW7
-
brenda
Q8GYW7
-
brenda
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
brain-specific isozyme
brenda
-
-
brenda
-
-
brenda
-
only peroxisomal isozyme, no mitochondrial and cytosolic isozyme activity
brenda
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isozyme CTE-I
brenda
strong expression of MTE-I, expression of CTE-I, PTE-Ib, and PTE-Ia
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
brain-specific enzyme, several isoforms
brenda
PPT1 is localized in the presynaptic compartment and is most likely associated with the synaptosomes and synaptic vesicles. PPT1 deficiency causes an abnormally low level of synaptic vesicle proteins in the soluble fractions of the postmortem brain tissues from an infantile neuronal ceroid lipofuscinosis patient
brenda
-
-
brenda
-
-
brenda
-
brenda
-
expression of isozyme CTE-I, not MTE-I
brenda
central and peripheric nervous system, brain-specific isozyme
brenda
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major isozyme brain acyl-CoA hydrolase, enzyme expression level during pre- and post-natal brain development
brenda
major isozyme is CTE-I, poor expression of MTE-I, expression of PTE-Ia, no expression of PTE-Ib
brenda
-
expression in a neuron-specific manner. The level of the major 43000 Da isoform is low until embryonic day 12.5, elevates to a peak 7 days after birth. Thereafter, it declines somewhat and reaches a steady-state level in adulthood
brenda
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localized exclusively in neurons
brenda
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Acot7 is expressed mainly in brain and testis of male mice. In female mice, mRNA expression of Acot7 isoforms is highest in brain, lung, kidney, heart and ovary
brenda
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PPT1 is localized in the presynaptic compartment
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
expression of isozyme CTE-I and MTE-I
brenda
strong expression of MTE-I, expression of CTE-I, PTE-Ib, and PTE-Ia
brenda
-
-
brenda
-
brenda
-
brenda
-
-
brenda
brain-specific isozyme
brenda
-
-
brenda
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placental
brenda
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i.e. BeWo cells
brenda
-
-
brenda
strong expression
brenda
strong expression. ACOT2 is much more strongly expressed than ACOT1
brenda
-
brenda
-
expression of isozyme CTE-I and MTE-I
brenda
strong expression of MTE-I, expression of CTE-I and PTE-Ia, no expression of PTE-Ib
brenda
-
moderate expression in male mice. In female mice, mRNA expression of Acot7 isoforms is highest in brain, lung, kidney, heart and ovary
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
brenda
-
brenda
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differential regulation of distinct ACSl isoforms at the transcriptional level
brenda
treatment with a PPARalpha agonist (peroxisome proliferator-activated receptor alpha agonist) increases MTE-1 mRNA, protein expression, and activity and the rate of palmitate export from isolated cardiac mitochondria, suggesting that MTE-I functions to regulate the concentration of long-chain fatty acyl-CoA in the mitochondrial matrix through the generation and export of free fatty acid anions. Thus, upregulation of MTE-I activity may prevent the accumulation of long-chain fatty acyl-CoA in the mitochondrial matrix when the heart is exposed to high levels of fatty acids
brenda
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cytosolic acyl-CoA thioester hydrolases are deranged in hippocampus of patients with mesial temperal lobe epilepsy
brenda
-
-
brenda
strong expression
brenda
-
brenda
-
isozymes CTE-I and MTE-I expression
brenda
major isozyme is CTE-I, strong expression of MTE-I, expression of PTE-Ia and PTE-Ib
brenda
-
weak expression of Acot7 in male mice
brenda
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medulla
brenda
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-
brenda
-
brenda
-
-
brenda
highest content
brenda
Q8GYW7
young
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
strong expression
brenda
strong expression. ACOT2 is much more strongly expressed than ACOT1
brenda
-
-
brenda
-
brenda
-
brenda
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isozyme CTE-I expression, low amount of isozyme MTE-I
brenda
major isozyme is CTE-I, only weak expression of PTE-Ia, expression of PTE-Ib, no expression of MTE-I
brenda
Acot1 mRNA levels are increased by 90fold in liver by treatment with Wy-14,643. Acot1 mRNA is also increased by 15fold in the liver of hepatocyte nuclear factor 4a (HNF4alpha) knockout animals. Acot1 is under regulation by an interplay between HNF4alpha and PPARalpha
brenda
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weak expression of Acot7 in male mice
brenda
-
-
80783, 80785, 80787, 80791, 94478, 171023, 646115, 646118, 646121, 646128, 646129, 646134, 646137, 646138, 646140, 646141, 646144, 646150, 646151, 646155, 646157 brenda
-
brenda
-
-
brenda
-
brenda
-
-
brenda
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brenda
-
-
brenda
-
brenda
-
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-
brenda
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of rats treated with 3-thia fatty acids, i.e. tetradecylthioacetic acid and 3-dithiacarboxylic acid
brenda
major isozyme is CTE-I, strong expression of MTE-I, expression of PTE-Ia, no expression of PTE-Ib
brenda
-
moderate expression in male mice. In female mice, mRNA expression of Acot7 isoforms is highest in brain, lung, kidney, heart and ovary
brenda
-
-
brenda
strong expression
brenda
strong expression. ACOT2 is much more strongly expressed than ACOT1
brenda
-
brenda
-
low expression of isozyme MTE-I
brenda
strong expression of MTE-I, only weak expression of CTE-I, expression of PTE-Ia, no expression of PTE-Ib
brenda
-
weak expression of Acot7 in male mice
brenda
-
-
brenda
cell body and neurites, brain-specific isozyme
brenda
-
-
brenda
-
-
brenda
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in female mice, mRNA expression of Acot7 isoforms is highest in brain, lung, kidney, heart and ovary
brenda
-
-
brenda
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choriocarcinoma cell
brenda
weak expression
brenda
-
-
brenda
strong expression of MTE-I, expression of CTE-I and PTE-Ia, no expression of PTE-Ib
brenda
-
weak expression of Acot7 in male mice
brenda
-
-
brenda
-
-
brenda
-
brenda
-
expression of isozyme CTE-I, not MTE-I
brenda
brain-specific isozyme
brenda
major isozyme is CTE-I, poor expression of MTE-I, expression of PTE-Ia, no expression of PTE-Ib
brenda
before postnatal day 10 the enzyme is detected at very low levels, the enzyme content rapidly increases from postnatal day 14 and reaches maximal levels at postnatal day 21, remaining high until at least postnatal day 70
brenda
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Acot7 is expressed mainly in brain and testis of male mice
brenda
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-
brenda
-
brenda
-
brenda
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expression of isozyme CTE-I and MTE-I
brenda
strong expression of MTE-I, expression of CTE-I, PTE-Ib, and PTE-Ia
brenda
-
adrenocortical tumour cell line
brenda
-
ACS4 is rapidly induced by adrenocorticotropin and cAMP in Y1 adrenocortical cells
brenda
additional information
-
expression level during plant development
brenda
additional information
Q8GYW7
expression level during plant development
brenda
additional information
palmitoyl-CoA hydrolase activity is widespread in all tissues
brenda
additional information
-
palmitoyl-CoA hydrolase activity is widespread in all tissues
brenda
additional information
ubiquitous expression
brenda
additional information
-
ubiquitous expression
brenda
additional information
ubiquitous expression
brenda
additional information
-
ubiquitous expression
brenda
additional information
palmitoyl-CoA hydrolase activity is widespread in all tissues
brenda
additional information
-
palmitoyl-CoA hydrolase activity is widespread in all tissues
brenda
additional information
no activity in spermatogonia
brenda
additional information
-
no activity in spermatogonia
brenda
additional information
-
Acot7 gene is expressed as multiple isoforms in a tissue-specific manner. Expression in tissues other than brain and testis is likely to play important roles in fatty acid metabolism. Identification of five possible first exons in mouse Acot7 (Acot7ae). All five first exons are transcribed in a tissue-specific manner
brenda
additional information
-
-
brenda
additional information
-
-
brenda
additional information
tissue distribution
brenda
additional information
tissue distribution
brenda
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hanging drop method, protein solution: 10 mg/ml, 5 mM NH4OH, 2 mM DTT, over equal volume of reservoir solution: 1-2 M NaCl, 0.1 M sodium formate, pH 6.0, 2 mM N,N-dimethyl-dodecylamine oxide-LDAO, few days, X-ray structure determination and analysis
purified recombinant His-tagged enzyme, 76.8 mg/ml, hanging-drop vapour-diffusion method, protein solution: 10 mM sodium phosphate, pH 7.0, plus equal volme of reservoir solution: 0.2 M ammonium sulfate, 27% w/w PEG-MME 5K, 0.1 M 2-[N-morpholino]ethanesulfonic acid, pH 6.5, room temperature, crystals appeared after 7-21 d, X-ray diffraction structure determination and analysis at 2.4 A resolution
-
docking studies to the pocket of the catalytic triad Ser 2308, His 2481, and Asp 2338, using palmitate, and fatty acids with chain lengths of 12 to 20 carbon atoms. The ligand binding pocket of the thioesterase domain is a decisive factor in chain length specificity. Binding of palmitate results in the most favorable binding free enrgy among the fatty acids tested. The experimentally amino acids of the catalytic triad Ser2308, His2481, and Asp2338 are located very close to the carboxyl group of palmitate. The close location of Arg2482 to the carboxyl group of palmitate and the catalytic triad implies an important role of this residue in catalysis
-
hanging-drop vapor diffusion in 20% PEG 2000. Crystal structures of both the N- and C-terminal domains of the mouse enzyme. The quaternary arrangement in Acot7 features a trimer of hotdog fold dimers
vapour diffusion using PEG 2000 MME as precipitant at pH 7.0 and 17°C. Crystals have the symmetry of space group R32 (unit-cell parameters a = b = 136.83, c = 99.82 A, gamma = 120°). Two molecules are expected in the asymmetric unit. The crystals diffract to 2.4 A resolution using the laboratory X-ray source and are suitable for crystal structure determination
vapour diffusion using PEG 2000 MME as precipitant at pH 7.0 and 17°C. The crystals have the symmetry of space group R32 (unit-cell parameters a = b = 136.83, c = 99.82 A, gamma = 120°). Two molecules in the asymmetric unit. The crystals diffract to 2.4 A resolution
hanging-drop vapor-diffusion method, crystal structure to 2.3 A resolution. FcoT crystals, produced in the presence of the substrate dodecenoyl-CoA, are cubic and belong to space group I2(1)3, with one molecule in the asymmetric unit
determined at 1.05 A, revealing a hotdog hydrolase fold arranged as a dimer of dimers. A second crystal structure at 1.40 A iss obtained from a crystal that is grown in the presence of Mg2+, which reveals the presence of a binding site for divalent cations at a crystal contact. The Mg2+-bound structure shows localized conformational changes, and its active site is unoccupied, suggesting a mechanism to open the active site for substrate entry or product release
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D154A
kcat/KM for p-nitrophenyl butyrate is 18% of wild-type value. kcat/KM for lauroyl-CoA is 11% of wild-type value. kcat/KM for N-carbobenzoxy-L-tyrosine p-nitrophenyl ester is 29% of wild-type value
G44A
kcat/KM for p-nitrophenyl butyrate is 16% of wild-type value. kcat/KM for lauroyl-CoA is 15% of wild-type value. kcat/KM for N-carbobenzoxy-L-tyrosine p-nitrophenyl ester is 25% of wild-type value
H157A
kcat/KM for p-nitrophenyl butyrate is 0.09% of wild-type value
L109P
mutation shifts the substrate-preference from medium-to-long acyl chains to shorter acyl-chains of triglyceride and p-nitrophenyl ester, and increases the preference for aromatic-amino acid-derived esters. kcat for lauroyl-CoA is 17.8fold lower than wild-type value, Km-value for lauroyl-CoA is 1.3fold higher than wild-type value
N73A
kcat/KM for p-nitrophenyl butyrate is 41% of wild-type value. kcat/KM for lauroyl-CoA is 19% of wild-type value. kcat/KM for N-carbobenzoxy-L-tyrosine p-nitrophenyl ester is 35% of wild-type value
P110A
kcat for lauroyl-CoA is 2.7fold lower than wild-type value, Km-value for lauroyl-CoA is 1.3fold lower than wild-type value
P110A/L109P
kcat for lauroyl-CoA is 12fold lower than wild-type value, Km-value for lauroyl-CoA is 2fold lower than wild-type value
S10A
kcat/KM for p-nitrophenyl butyrate is 0.57% of wild-type value. kcat/KM for lauroyl-CoA is 0.6% of wild-type value. kcat/KM for N-carbobenzoxy-L-tyrosine p-nitrophenyl ester is 0.06% of wild-type value
D213A
mutation results in a strong reduction in catalytic activity
E39A
mutation does not affect activity
E39D/T198N
mutant displays a 4fold increase in the catalytic activity compared with wild-type Acot7
N24A
mutation results in a strong reduction in catalytic activity
T198A
mutation does not affect activity
E77Q
mutation decreased the enzyme activity to less than 10fold of wild-type
H72A
mutation decreased the enzyme activity to less than 10fold of wild-type
N74A
mutation abolishes the activity of the enzyme
N83A
mutation decreased the enzyme activity to less than 10fold of wild-type
Y33F
mutation abolishes the activity of the enzyme
Y66F
mutation abolishes the activity of the enzyme
Y87F
mutation decreased the enzyme activity to less than 10fold of wild-type
E77Q
-
mutation decreased the enzyme activity to less than 10fold of wild-type
-
N74A
-
mutation abolishes the activity of the enzyme
-
N83A
-
mutation decreased the enzyme activity to less than 10fold of wild-type
-
Y33F
-
mutation abolishes the activity of the enzyme
-
Y87F
-
mutation decreased the enzyme activity to less than 10fold of wild-type
-
D17A
mutant shows no activity
D17A
-
mutant shows no activity
-
additional information
-
a AtACH5 gene knock-out mutant shows no altered phenotype
additional information
-
AtACH5 knockout mutants do not have an altered phenotype
additional information
-
PPARalpha-null mice are not stimulated by clofibrate
additional information
-
mutant PML1551 deficient in OM esterase activity
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3 isozymes with differences in the 5'-end sequences, DNA and amino acid sequence determination and analysis, gene structure, functional expression in Escherichia coli BL21(DE3), expression in neuroblastoma cell line Neuro-2a
BACH, stable expression in C3H 10T1/2 fibroblastic cell line using an mifepristone (RU486)-inducible expression system as C-terminally MYC-tagged enzyme
-
DNA and amino acid sequence determination and analysis, expression in CHO cells
DNA sequence determination and analysis of isolated and commercial clone, overexpression of His-tagged isozyme ACH2 in Escherichia coli BL21(DE3) cells
Q8GYW7
DNA sequence determination and analysis, chromosome mapping 1p36.2, expression in Escherichia coli
DNA sequence determination and analysis, expression in Escherichia coli BL21(DE3)
DNA sequence determination and analysis, expression in Escherichia coli fused to maltose-binding protein
DNA sequence determination and analysis, subcloning in Escherichia coli, and expression in CHO cells
DNA sequence determination and analysis, subcloning in Escherichia coli, expression fused to maltose-binding-protein in Escherichia coli strain DH10B
expressed as a GST-fusion protein in Escherichia coli
expressed in Escherichia coli strains JW1794-1 and RU42-RU48
expressed in Saccharomyces cerevisiae strain BY4741
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expression as His-tagged enzyme in Escherichia coli and as GST-fusion protein in bacteria
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expression in Escherichia coli
expression in Escherichia coli BL21 as His-tagged protein
expression of cDNA in chinese hamster ovary cells
from murine EST library, DNA and amino acid sequence determination and analysis, transient expression in HeLa cells, expression as inactive GST-fusion protein in bacteria
functional overexpression of AtACH2 in Escherichia coli, overexpression of AtACH5 fused to the green fluorescent protein in Escherichia coli
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gene ACH2, DNA and amino acid sequence determination and analysis, overexpression as C-terminally His-tagged protein in Escherichia coli BL21(DE3)
Q8GYW7
gene BACH comprises 13 exons through alternative use of exons and splicing, DNA and amino acid sequence determination, expression as green-fluorescent-protein fusion protein in Neuro-2a cells
gene scoT, DNA and amino acid sequence determinatin and analysis, expression and functional complementation in deficient Streptomyces fradiae strain
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gene tes B, DNA sequence determination and analysis, no sequence similarity between Escherichia coli thioesterase II and the two types of mammalian thioesterases, i.e. the chain-terminating enzymes of de novo fatty acid synthesis
gene tesB, overexpression in the Escherichia coli host strain
gene YJR019C, DNA sequence determination and analysis, subcloning in Escherichia coli, expression fused to maltose-binding-protein in Escherichia coli strain DH10B
genes CTE-I, MTE-I, PTE-Ia and PTE-Ib, DNA and amino acid sequence determination and analysis, promotor cloning, genes possess targeting sequences for subcellular compartment localization, genes are organized in a narrow cluster on chromosome 12, expression of CTE-I in HepG2 cells
isozyme PTE-2, DNA sequence determination and analysis
isozyme PTE-2, DNA sequence determination and analysis, expression as green-fluorescent-protein fusion protein in human skin fibroblasts
isozymes CTE-I and MTE-I, DNA sequence and promotor analysis
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isozymes MTE-I, His-tagged, and CTE-I, both GST-fusion proteins
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overexpression in Escherichia coli BL-21(DE3) as a His-tagged protein
Q8GYW7
overexpression of isozymes AtACH5and AtACH2 in Escherichia coli , AtACH2 fused to maltose-binding protein
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expression in Escherichia coli
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expression in Escherichia coli
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expression in Escherichia coli
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expression in Escherichia coli
expression in Escherichia coli
expression of cDNA in chinese hamster ovary cells
expression of cDNA in chinese hamster ovary cells
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