Reference on EC 3.1.13.3 - oligonucleotidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Futai, M.; Mizuno, D.
A new phosphodiesterase forming nucleoside 5'-monophosphate from rat liver. Its partial purification and substrate specificity for nicotinamide adenine dinucleotide and oligonucleotides
J. Biol. Chem.
242
5301-5307
1967
Rattus norvegicus
Niyogi, S.K.; Datta, A.K.
A novel oligoribonuclease of Escherichia coli. I. Isolation and properties
J. Biol. Chem.
250
7307-7312
1975
Escherichia coli
Datta, A.K.; Niyogi, S.N.
A novel oligoribonuclease of Escherichia coli. II. Mechanism of action
J. Biol. Chem.
250
7313-7319
1975
Escherichia coli
Elson,D.
Latent enzymic activity of a ribonucleoprotein isolated from Escherichia coli
Biochim. Biophys. Acta
36
372-386
1959
Escherichia coli
Kurosawa, S.; Shimabuku, A.M.; Ishizawa, H.; Sen, K.
Oligonucleotidase activity of phosphodiesterase from the fruit body of Flammulina velutipes
Agric. Biol. Chem.
54
587-592
1990
Flammulina velutipes
Yu, D.; Deutscher, M.P.
Oligoribonuclease is distinct from the other known exoribonucleases of Escherichia coli
J. Bacteriol.
177
4137-4139
1995
Escherichia coli
Zhang, X.; Zhu, L.; Deutscher, M.P.
Oligoribonuclease is encoded by a highly conserved gene in the 3'-5' exonuclease superfamily
J. Bacteriol.
180
2779-2781
1998
BRENDA: Escherichia coli
Textmining: Homo sapiens
Ghosh, S.; Deutscher, M.P.
Oligoribonuclease is an essential component of the mRNA decay pathway
Proc. Natl. Acad. Sci. USA
96
4372-4377
1999
BRENDA: Escherichia coli
Textmining: eukaryota, Homo sapiens
Fiedler, T.J.; Vincent, H.A.; Zuo, Y.; Gavrialov, O.; Malhotra, A.
Purification and crystallization of Escherichia coli oligoribonuclease
Acta Crystallogr. Sect. D
60
736-739
2004
Escherichia coli
Wu, Y.Y.; Chin, K.H.; Chou, C.C.; Lee, C.C.; Shr, H.L.; Gao, F.P.; Lyu, P.C.; Wang, A.H.; Chou, S.H.
Cloning, purification, crystallization and preliminary X-ray crystallographic analysis of XC847, a 3'-5' oligoribonuclease from Xanthomonas campestris
Acta Crystallogr. Sect. F
61
902-905
2005
BRENDA: Xanthomonas campestris
Textmining: bacterium, plant, Xanthomonas campestris pv. campestris
Zhang, X.X.; Lilley, A.K.; Bailey, M.J.; Rainey, P.B.
Functional and phylogenetic analysis of a plant-inducible oligoribonuclease (orn) gene from an indigenous Pseudomonas plasmid
Microbiology
150
2889-2898
2004
BRENDA: Pseudomonas sp.
Textmining: Pseudomonas
Mechold, U.; Ogryzko, V.; Ngo, S.; Danchin, A.
Oligoribonuclease is a common downstream target of lithium-induced pAp accumulation in Escherichia coli and human cells
Nucleic Acids Res.
34
2364-2373
2006
Homo sapiens, Escherichia coli (P0A784), Escherichia coli
Mechold, U.; Fang, G.; Ngo, S.; Ogryzko, V.; Danchin, A.
YtqI from Bacillus subtilis has both oligoribonuclease and pAp-phosphatase activity
Nucleic Acids Res.
35
4552-4561
2007
BRENDA: Bacillus subtilis, Escherichia coli
Textmining: Firmicutes
Young Park, A.; Elvin, C.M.; Hamdan, S.M.; Wood, R.J.; Liyou, N.E.; Hamwood, T.E.; Jennings, P.A.; Dixon, N.E.
Hydrolysis of the 5-p-nitrophenyl ester of TMP by oligoribonucleases (ORN) from Escherichia coli, Mycobacterium smegmatis, and human
Protein Expr. Purif.
57
180-187
2008
Escherichia coli, Homo sapiens, Mycolicibacterium smegmatis
Chin, K.; Yang, C.; Chou, C.; Wang, A.H.; Chou, S.
The crystal structure of XC847 from Xanthomonas campestris: A 3-5 oligoribonuclease of DnaQ fold family with a novel opposingly shifted helix
Proteins Struct. Funct. Bioinform.
65
1036-1040
2006
Xanthomonas campestris
Zuo, Y.; Zheng, H.; Wang, Y.; Chruszcz, M.; Cymborowski, M.; Skarina, T.; Savchenko, A.; Malhotra, A.; Minor, W.
Crystal structure of RNase T, an exoribonuclease involved in tRNA maturation and end turnover
Structure
15
417-428
2007
Escherichia coli (P30014), Escherichia coli, Pseudomonas aeruginosa (Q9HY82), Pseudomonas aeruginosa
Sello, J.K.; Buttner, M.J.
The oligoribonuclease gene in Streptomyces coelicolor is not transcriptionally or translationally coupled to adpA, a key bldA target
FEMS Microbiol. Lett.
286
60-65
2008
Streptomyces coelicolor
Liu, M.F.; Cescau, S.; Mechold, U.; Wang, J.; Cohen, D.; Danchin, A.; Boulouis, H.J.; Biville, F.
Identification of a novel nanoRNase in Bartonella
Microbiology
158
886-895
2012
BRENDA: Bartonella birtlesii (G4VUY7), Bartonella birtlesii, Bartonella birtlesii IBS 325 (G4VUY7), Bartonella henselae
Textmining: bacterium, Bartonella, Escherichia coli
Bruni, F.; Gramegna, P.; Oliveira, J.M.; Lightowlers, R.N.; Chrzanowska-Lightowlers, Z.M.
REXO2 is an oligoribonuclease active in human mitochondria
PLoS ONE
8
e64670
2013
BRENDA: Homo sapiens (Q9Y3B8), Homo sapiens
Textmining: Escherichia coli
Romano, M.; Van De Weerd, R.; Brouwer, F.; Roviello, G.; Lacroix, R.; Sparrius, M.; Van Den Brink-Van Stempvoort, G.; Maaskant, J.; Van Der Sar, A.; Appelmelk, B.; Geurtsen, J.; Berisio, R.
Structure and function of RNase AS, a polyadenylate-specific exoribonuclease affecting mycobacterial virulence in vivo
Structure
22
719-730
2014
Escherichia coli
Chen, F.; Chen, G.; Liu, Y.; Jin, Y.; Cheng, Z.; Liu, Y.; Yang, L.; Jin, S.; Wu, W.
Pseudomonas aeruginosa oligoribonuclease contributes to Tolerance to ciprofloxacin by regulating pyocin biosynthesis
Antimicrob. Agents Chemother.
61
e02256-16
2017
Pseudomonas aeruginosa (Q02F67), Pseudomonas aeruginosa
Cohen, D.; Mechold, U.; Nevenzal, H.; Yarmiyhu, Y.; Randall, T.E.; Bay, D.C.; Rich, J.D.; Parsek, M.R.; Kaever, V.; Harrison, J.J.; Banin, E.
Oligoribonuclease is a central feature of cyclic diguanylate signaling in Pseudomonas aeruginosa
Proc. Natl. Acad. Sci. USA
112
11359-11364
2015
BRENDA: Pseudomonas aeruginosa (P57665), Pseudomonas aeruginosa, Pseudomonas aeruginosa ATCC 15692 (P57665), Pseudomonas aeruginosa 1C (P57665), Pseudomonas aeruginosa PRS 101 (P57665), Pseudomonas aeruginosa DSM 22644 (P57665), Pseudomonas aeruginosa CIP 104116 (P57665), Pseudomonas aeruginosa LMG 12228 (P57665), Pseudomonas aeruginosa JCM 14847 (P57665)
Textmining: Actinobacteria
Orr, M.W.; Donaldson, G.P.; Severin, G.B.; Wang, J.; Sintim, H.O.; Waters, C.M.; Lee, V.T.
Oligoribonuclease is the primary degradative enzyme for pGpG in Pseudomonas aeruginosa that is required for cyclic-di-GMP turnover
Proc. Natl. Acad. Sci. USA
112
E5048-E5057
2015
Pseudomonas aeruginosa (Q02F67), Pseudomonas aeruginosa
Zhou, J.; Zheng, Y.; Roembke, B.; Robinson, S.; Opoku-Temeng, C.; Sayre, D.; Sintim, H.
Fluorescent analogs of cyclic and linear dinucleotides as phosphodiesterase and oligoribonuclease activity probes
RSC Adv.
7
5421-5426
2017
Pseudomonas aeruginosa (A0A069Q255), Mycolicibacterium smegmatis (A0A8B4R3D6), Escherichia coli (P0A784)
-
Lee, C.W.; Park, S.H.; Jeong, C.S.; Cha, S.S.; Park, H.; Lee, J.H.
Structural basis of small RNA hydrolysis by oligoribonuclease (CpsORN) from Colwellia psychrerythraea strain 34H
Sci. Rep.
9
2649
2019
BRENDA: Colwellia psychrerythraea (Q47VZ4), Colwellia psychrerythraea ATCC BAA-681 (Q47VZ4)
Textmining: Colwellia psychrerythraea 34H
Deng, YJ; Feng, L; Zhou, H; Xiao, X; Wang, FP; Liu, XP
NanoRNase from Aeropyrum pernix shows nuclease activity on ssDNA and ssRNA.
DNA Repair (Amst)
65
54-63
2018
Aeropyrum pernix
Viswanathan, M; Dower, KW; Lovett, ST
Identification of a potent DNase activity associated with RNase T of Escherichia coli.
J Biol Chem
273
35126-31
1998
Escherichia coli
Viswanathan, M; Lovett, ST
Exonuclease X of Escherichia coli. A novel 3'-5' DNase and Dnaq superfamily member involved in DNA repair.
J Biol Chem
274
30094-100
1999
Escherichia coli, bacterium
Moser, MJ; Holley, WR; Chatterjee, A; Mian, IS
The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains.
Nucleic Acids Res
25
5110-8
1997
Escherichia coli, Borreliella burgdorferi, Bacillus subtilis, Methanocaldococcus jannaschii, Schizosaccharomyces pombe, Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, Xenopus laevis, Mus musculus, Escherichia virus T4
Zhu, X; Baranowski, E; Dong, Y; Li, X; Hao, Z; Zhao, G; Zhang, H; Lu, D; A Rasheed, M; Chen, Y; Hu, C; Chen, H; Sagn, E; Citti, C; Guo, A
An emerging role for cyclic dinucleotide phosphodiesterase and nanoRNase activities in Mycoplasma bovis: Securing survival in cell culture.
PLoS Pathog
16
e1008661
2020
Mycoplasmopsis bovis
Viswanathan, M; Lanjuin, A; Lovett, ST
Identification of RNase T as a high-copy suppressor of the UV sensitivity associated with single-strand DNA exonuclease deficiency in Escherichia coli.
Genetics
151
929-34
1999
Escherichia coli, plasmids
Yuan, F; Dutta, T; Wang, L; Song, L; Gu, L; Qian, L; Benitez, A; Ning, S; Malhotra, A; Deutscher, MP; Zhang, Y
Human DNA Exonuclease TREX1 Is Also an Exoribonuclease That Acts on Single-stranded RNA.
J Biol Chem
290
13344-53
2015
Homo sapiens
Harada, F; Kimura, F; Nishimura, S
Primary sequence of tRNA val from Escherichia coli B. I. Oligonucleotide sequences of digests of Escherichia coli tRNA val with RNase T and pancreatic RNase.
Biochemistry
10
3269-77
1971
Escherichia, Escherichia coli, Escherichia coli B
Abendroth, J; Ollodart, A; Andrews, ES; Myler, PJ; Staker, BL; Edwards, TE; Arcus, VL; Grundner, C
Mycobacterium tuberculosis Rv2179c protein establishes a new exoribonuclease family with broad phylogenetic distribution.
J Biol Chem
289
2139-47
2014
Escherichia coli
Huang, S; Deutscher, MP
Sequence and transcriptional analysis of the Escherichia coli rnt gene encoding RNase T.
J Biol Chem
267
25609-13
1992
Escherichia coli
Padmanabha, KP; Deutscher, MP
RNase T affects Escherichia coli growth and recovery from metabolic stress.
J Bacteriol
173
1376-81
1991
Escherichia coli, Bacteriophage sp.
Deutscher, MP; Marlor, CW; Zaniewski, R
RNase T is responsible for the end-turnover of tRNA in Escherichia coli.
Proc Natl Acad Sci U S A
82
6427-30
1985
Escherichia coli
Case, LM; Chen, XN; Deutscher, MP
Localization of the Escherichia coli rnt gene encoding RNase T by using a combination of physical and genetic mapping.
J Bacteriol
171
5736-7
1989
Escherichia coli
Deutscher, MP; Marlor, CW
Purification and characterization of Escherichia coli RNase T.
J Biol Chem
260
7067-71
1985
Escherichia coli
Harada, F; Yamaizumi, K; Nishimura, S
Oligonucleotide sequences of RNase T 1 and pancreatic RNase digests of E. coli aspartic acid tRNA.
Biochem Biophys Res Commun
49
1605-9
1972
Escherichia coli
Li, Z; Zhan, L; Deutscher, MP
The role of individual cysteine residues in the activity of Escherichia coli RNase T.
J Biol Chem
271
1127-32
1996
Escherichia coli
Li, Z; Zhan, L; Deutscher, MP
Escherichia coli RNase T functions in vivo as a dimer dependent on cysteine 168.
J Biol Chem
271
1133-7
1996
Escherichia coli
Ohnishi, Y; Nishiyama, Y; Sato, R; Kameyama, S; Horinouchi, S
An oligoribonuclease gene in Streptomyces griseus.
J Bacteriol
182
4647-53
2000
Streptomyces griseus
Mwaengo, DM; Lawrence, PO
A putative DNA helicase and novel oligoribonuclease in the Diachasmimorpha longicaudata entomopoxvirus (DlEPV).
Arch Virol
148
1431-44
2003
Diachasmimorpha longicaudata entomopoxvirus
Ito, S; Kita, K; Zhai, L; Wano, C; Suzuki, T; Yamaura, A; Suzuki, N
Involvement of human small fragment nuclease in the resistance of human cells to UV-C-induced cell death.
Photochem Photobiol
80
281-5
0
Homo sapiens
Uemura, Y; Nakagawa, N; Wakamatsu, T; Kim, K; Montelione, GT; Hunt, JF; Kuramitsu, S; Masui, R
Crystal structure of the ligand-binding form of nanoRNase from Bacteroides fragilis, a member of the DHH/DHHA1 phosphoesterase family of proteins.
FEBS Lett
587
2669-74
2013
Bacteroides fragilis
Chen, G; Zhao, Q; Zhu, F; Chen, R; Jin, Y; Liu, C; Pan, X; Jin, S; Wu, W; Cheng, Z
Oligoribonuclease is required for the type III secretion system and pathogenesis of Pseudomonas aeruginosa.
Microbiol Res
188-189
90-6
0
Pseudomonas aeruginosa
Schmier, BJ; Nelersa, CM; Malhotra, A
Structural Basis for the Bidirectional Activity of Bacillus nanoRNase NrnA.
Sci Rep
7
11085
2017
Bacillus
Wellner, K; Phler, MT; Betat, H; Mrl, M
Dual expression of CCA-adding enzyme and RNase T in Escherichia coli generates a distinct cca growth phenotype with diverse applications.
Nucleic Acids Res
47
3631-3639
2019
Escherichia coli
Chu, LY; Agrawal, S; Chen, YP; Yang, WZ; Yuan, HS
Structural insights into nanoRNA degradation by human Rexo2.
RNA
25
737-746
2019
Homo sapiens, Escherichia coli
Xia, B; Li, M; Tian, Z; Chen, G; Liu, C; Xia, Y; Jin, Y; Bai, F; Cheng, Z; Jin, S; Wu, W
Oligoribonuclease Contributes to Tolerance to Aminoglycoside and ?-Lactam Antibiotics by Regulating KatA in Pseudomonas aeruginosa.
Antimicrob Agents Chemother
63
2019
Pseudomonas aeruginosa
Piotrowski, Y; Berg, K; Klebl, DP; Leiros, I; Larsen, AN
Characterization of an intertidal zone metagenome oligoribonuclease and the role of the intermolecular disulfide bond for homodimer formation and nuclease activity.
FEBS Open Bio
2019
metagenome
Szewczyk, M; Malik, D; Borowski, LS; Czarnomska, SD; Kotrys, AV; Klosowska-Kosicka, K; Nowotny, M; Szczesny, RJ
Human REXO2 controls short mitochondrial RNAs generated by mtRNA processing and decay machinery to prevent accumulation of double-stranded RNA.
Nucleic Acids Res
48
5572-5590
2020
Homo sapiens
Reuven, NB; Koonin, EV; Rudd, KE; Deutscher, MP
The gene for the longest known Escherichia coli protein is a member of helicase superfamily II.
J Bacteriol
177
5393-400
1995
Escherichia coli
Nguyen, LH; Erzberger, JP; Root, J; Wilson, DM
The human homolog of Escherichia coli Orn degrades small single-stranded RNA and DNA oligomers.
J Biol Chem
275
25900-6
2000
Homo sapiens
Postic, G; Danchin, A; Mechold, U
Characterization of NrnA homologs from Mycobacterium tuberculosis and Mycoplasma pneumoniae.
RNA
18
155-65
2012
Escherichia coli
Mohanty, BK; Maples, VF; Kushner, SR
Polyadenylation helps regulate functional tRNA levels in Escherichia coli.
Nucleic Acids Res
2012
Escherichia coli
Fang, M; Zeisberg, WM; Condon, C; Ogryzko, V; Danchin, A; Mechold, U
Degradation of nanoRNA is performed by multiple redundant RNases in Bacillus subtilis.
Nucleic Acids Res
37
5114-25
2009
Bacillus subtilis, Escherichia coli
Nelersa, CM; Schmier, BJ; Malhotra, A
Purification and crystallization of Bacillus subtilis NrnA, a novel enzyme involved in nanoRNA degradation.
Acta Crystallogr Sect F Struct Biol Cryst Commun
67
1235-8
2011
Escherichia coli, eukaryota
Sun, W; Lou, YH; Dean, J; Tung, KS
A contraceptive peptide vaccine targeting sulfated glycoprotein ZP2 of the mouse zona pellucida.
Biol Reprod
60
900-7
1999
Bos taurus
Condon, C
RNA processing and degradation in Bacillus subtilis.
Microbiol Mol Biol Rev
67
157-74, table of contents
2003
Bacillus subtilis, Escherichia coli
Zhang, J; Biswas, I
A pAp-phosphatase activity is required for superoxide stress tolerance in Streptococcus mutans.
J Bacteriol
2009
Escherichia coli, Bacillus subtilis
Ma, Y; Zhou, G; Li, Y; Zhu, Y; Yu, X; Zhao, F; Li, H; Xu, X; Li, C
Intake of Fish Oil Specifically Modulates Colonic Muc2 Expression in Middle-Aged Rats by Suppressing the Glycosylation Process.
Mol Nutr Food Res
62
2018
Chondrichthyes
Zuo, Y; Deutscher, MP
The DNase activity of RNase T and its application to DNA cloning.
Nucleic Acids Res
27
4077-82
1999
Escherichia coli, Vigna radiata var. radiata
Harshman, S; Conlin, JG; Stoller, D; Harshman, DL
Uncapping of viral messenger RNA by phosphodiesterase of fibroblast plasma membranes.
J Membr Biol
50
177-85
1979
Mus musculus, Reovirus sp., vesicular stomatitis virus
Hsiao, YY; Fang, WH; Lee, CC; Chen, YP; Yuan, HS
Structural Insights Into DNA Repair by RNase T-An Exonuclease Processing 3' End of Structured DNA in Repair Pathways.
PLoS Biol
12
e1001803
2014
Escherichia coli
Deutscher, MP; Marlor, CW; Zaniewski, R
Ribonuclease T: new exoribonuclease possibly involved in end-turnover of tRNA.
Proc Natl Acad Sci U S A
81
4290-3
1984
Escherichia coli
Li, Z; Pandit, S; Deutscher, MP
Maturation of 23S ribosomal RNA requires the exoribonuclease RNase T.
RNA
5
139-46
1999
Escherichia coli, stable RNAs
Zuo, Y; Deutscher, MP
The physiological role of RNase T can be explained by its unusual substrate specificity.
J Biol Chem
277
29654-61
2002
Escherichia coli, stable RNAs
Zuo, Y; Deutscher, MP
Mechanism of action of RNase T. II. A structural and functional model of the enzyme.
J Biol Chem
277
50160-4
2002
Escherichia coli
Zuo, Y; Deutscher, MP
Mechanism of action of RNase T. I. Identification of residues required for catalysis, substrate binding, and dimerization.
J Biol Chem
277
50155-9
2002
Escherichia coli
Duh, Y; Hsiao, YY; Li, CL; Huang, JC; Yuan, HS
Aromatic residues in RNase T stack with nucleobases to guide the sequence-specific recognition and cleavage of nucleic acids.
Protein Sci
2015
Escherichia coli
Laitman, Y; Tzur, S; Attai, R; Tirosh, A; Friedman, E
Germline variant in REXO2 is a novel candidate gene in familial pheochromocytoma.
Genet Res (Camb)
102
e3
2020
Homo sapiens
Calvanese, L; Squeglia, F; Romano, M; D'Auria, G; Falcigno, L; Berisio, R
Structural and dynamic studies provide insights into specificity and allosteric regulation of ribonuclease as, a key enzyme in mycobacterial virulence.
J Biomol Struct Dyn
1-13
2019
Escherichia coli
Orr, MW; Weiss, CA; Severin, GB; Turdiev, H; Kim, SK; Turdiev, A; Liu, K; Tu, BP; Waters, CM; Winkler, WC; Lee, VT
A subset of exoribonucleases serve as degradative enzymes for pGpG in c-di-GMP signaling.
J Bacteriol
2018
Pseudomonas aeruginosa, Phyla
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