Information on EC 3.1.11.4 - exodeoxyribonuclease (phage SP3-induced)

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The expected taxonomic range for this enzyme is: Enterobacteria phage SP

EC NUMBER
COMMENTARY hide
3.1.11.4
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RECOMMENDED NAME
GeneOntology No.
exodeoxyribonuclease (phage SP3-induced)
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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-
-
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CAS REGISTRY NUMBER
COMMENTARY hide
37288-30-5
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
oligo- and polydeoxyribonucleotides + H2O
dinucleotide + oligonucleotide
show the reaction diagram
-
hydrolysis on polynucleotides from the 5-termini of single-stranded DNA
-
?
single-stranded DNA + H2O
?
show the reaction diagram
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-
-
-
-
single-stranded DNA + H2O
dinucleotide + trinucleotide
show the reaction diagram
-
hydrolysis from the 5-and 3-termini of single-stranded DNA
general structure of dinucleotide is d-pX-pY and of trinucleotide is d-pX-pY-pZ
?
sorbitol-derivatized octanucleotides + H2O
dinucleotide + oligonucleotide
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
single-stranded DNA + H2O
?
show the reaction diagram
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-
-
-
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
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slight activity, no activity in less than 6.7 mM
Mg2+
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optimum for activation between 13 and 25 mM
Mn2+
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at 1.3 mM 44% of activation by Mg2+
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
N-cyclohexyl-N'-beta-(4-methylmorpholinium)-ethylcarbodiimide-derivatized DNA
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blocks enzyme activity absolutely, inhibition independent of nucleotide sequences
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
infected Bacillus subtilis
Manually annotated by BRENDA team
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
DEAE-cellulose, phosphocellulose, sucrose gradient sedimentation
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
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determination of the direction of hydrolysis of processive exonucleases